ZA201303610B - Novel cyclosporin derivatives for the treatment and prevention of a viral infection - Google Patents
Novel cyclosporin derivatives for the treatment and prevention of a viral infectionInfo
- Publication number
- ZA201303610B ZA201303610B ZA2013/03610A ZA201303610A ZA201303610B ZA 201303610 B ZA201303610 B ZA 201303610B ZA 2013/03610 A ZA2013/03610 A ZA 2013/03610A ZA 201303610 A ZA201303610 A ZA 201303610A ZA 201303610 B ZA201303610 B ZA 201303610B
- Authority
- ZA
- South Africa
- Prior art keywords
- prevention
- treatment
- viral infection
- cyclosporin derivatives
- novel cyclosporin
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
- 208000036142 Viral infection Diseases 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 230000009385 viral infection Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41932610P | 2010-12-03 | 2010-12-03 | |
| PCT/US2011/063295 WO2012075494A1 (en) | 2010-12-03 | 2011-12-05 | Novel cyclosporin derivatives for the treatment and prevention of a viral infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201303610B true ZA201303610B (en) | 2014-07-30 |
Family
ID=46172312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2013/03610A ZA201303610B (en) | 2010-12-03 | 2013-05-17 | Novel cyclosporin derivatives for the treatment and prevention of a viral infection |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP2646043B1 (enExample) |
| JP (1) | JP6093307B2 (enExample) |
| CN (1) | CN103249424B (enExample) |
| AU (1) | AU2011336266B2 (enExample) |
| BR (1) | BR112013015771A2 (enExample) |
| CA (1) | CA2819608C (enExample) |
| DK (1) | DK2646043T3 (enExample) |
| ES (1) | ES2625502T3 (enExample) |
| MX (1) | MX350746B (enExample) |
| PT (1) | PT2646043T (enExample) |
| RU (1) | RU2601742C2 (enExample) |
| WO (1) | WO2012075494A1 (enExample) |
| ZA (1) | ZA201303610B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103153329A (zh) | 2010-07-16 | 2013-06-12 | 美国科技环球有限公司 | 新颖的环孢霉素a衍生物在病毒感染的治疗和预防中的应用 |
| CN103153330B (zh) | 2010-08-12 | 2017-08-18 | 美国科技环球有限公司 | 新的环孢霉素衍生物在病毒感染的治疗和预防中的应用 |
| CA2814192A1 (en) | 2010-10-12 | 2012-04-19 | Allergan, Inc. | Cyclosporin analogs |
| JP5805773B2 (ja) | 2010-10-12 | 2015-11-10 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | シクロスポリンアナログ |
| US9890198B2 (en) | 2010-12-03 | 2018-02-13 | S&T Global Inc. | Cyclosporin derivatives and uses thereof |
| US9266927B2 (en) | 2012-06-01 | 2016-02-23 | Allergan, Inc. | Cyclosporin A analogs |
| WO2014049540A2 (en) * | 2012-09-29 | 2014-04-03 | Novartis Ag | Cyclic peptides and use as medicines |
| CN105960246A (zh) * | 2013-03-15 | 2016-09-21 | 美国科技环球有限公司 | 新型环孢菌素衍生物及其用途 |
| US9914755B2 (en) | 2015-01-08 | 2018-03-13 | Allergan, Inc. | Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized |
| CN109476705B (zh) * | 2016-05-17 | 2024-02-27 | 美国科技环球有限公司 | 新型环孢菌素衍生物及其用途 |
| EP3914655B1 (en) | 2019-01-24 | 2025-04-23 | Agfa Nv | Radiation curable inkjet inks for interior decoration |
| EP3686252A1 (en) | 2019-01-24 | 2020-07-29 | Agfa-Gevaert Nv | Radiation curable inkjet ink for manufacturing printed circuit boards |
| CA3128410A1 (en) * | 2019-10-11 | 2021-04-15 | Waterstone Pharmaceuticals (Wuhan) Co., Ltd. | Ws-635 uses thereof in medicine |
| WO2021209003A1 (en) | 2020-04-15 | 2021-10-21 | Farsight Medical Technology (Shanghai) Co., Ltd. | Prevention and treatment of organ injuries |
| CN112154151B (zh) * | 2020-06-04 | 2025-04-29 | 中美华世通生物医药科技(武汉)股份有限公司 | 治疗或预防冠状病毒科感染 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0194972B1 (en) * | 1985-03-11 | 1992-07-29 | Sandoz Ag | Novel cyclosporins |
| HUP9900405A3 (en) * | 1995-07-17 | 2001-04-28 | Scynexis Inc Durham | Cyclosporin derivatives with anti-hiv effect |
| US7511013B2 (en) * | 2004-09-29 | 2009-03-31 | Amr Technology, Inc. | Cyclosporin analogues and their pharmaceutical uses |
| US7196161B2 (en) * | 2004-10-01 | 2007-03-27 | Scynexis Inc. | 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection |
| CN101068829B (zh) * | 2004-10-01 | 2012-05-30 | 西尼克斯公司 | 用于治疗和预防丙型肝炎病毒感染的3-醚和3-硫醚取代的环孢菌素衍生物 |
| PL1802650T3 (pl) * | 2004-10-01 | 2012-04-30 | Scynexis Inc | 3-Etero i 3-tioetero podstawione pochodne cyklosporyny do leczenia i zapobiegania zakażeniu wirusem zapalenia wątroby typu C |
| MX2011007195A (es) * | 2009-01-07 | 2013-07-12 | Scynexis Inc | Derivado de ciclosporina para el uso en el tratamiento de infección de virus de hepatitis c (vhc) y virus de inmunodeficiencia humana (vih). |
| CA2751210C (en) * | 2009-01-30 | 2015-04-21 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues for preventing or treating hepatitis c infection |
| CN103153330B (zh) * | 2010-08-12 | 2017-08-18 | 美国科技环球有限公司 | 新的环孢霉素衍生物在病毒感染的治疗和预防中的应用 |
-
2011
- 2011-12-05 ES ES11845460.2T patent/ES2625502T3/es active Active
- 2011-12-05 CN CN201180058384.7A patent/CN103249424B/zh active Active
- 2011-12-05 BR BR112013015771A patent/BR112013015771A2/pt not_active IP Right Cessation
- 2011-12-05 PT PT118454602T patent/PT2646043T/pt unknown
- 2011-12-05 AU AU2011336266A patent/AU2011336266B2/en active Active
- 2011-12-05 RU RU2013130256/04A patent/RU2601742C2/ru active
- 2011-12-05 CA CA2819608A patent/CA2819608C/en active Active
- 2011-12-05 WO PCT/US2011/063295 patent/WO2012075494A1/en not_active Ceased
- 2011-12-05 MX MX2013006254A patent/MX350746B/es active IP Right Grant
- 2011-12-05 EP EP11845460.2A patent/EP2646043B1/en active Active
- 2011-12-05 DK DK11845460.2T patent/DK2646043T3/da active
- 2011-12-05 JP JP2013542244A patent/JP6093307B2/ja not_active Expired - Fee Related
-
2013
- 2013-05-17 ZA ZA2013/03610A patent/ZA201303610B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK2646043T3 (da) | 2017-05-22 |
| RU2013130256A (ru) | 2015-01-10 |
| MX350746B (es) | 2017-09-14 |
| CA2819608A1 (en) | 2012-06-07 |
| CA2819608C (en) | 2020-03-31 |
| CN103249424B (zh) | 2016-08-10 |
| RU2601742C2 (ru) | 2016-11-10 |
| EP2646043A4 (en) | 2014-05-28 |
| JP6093307B2 (ja) | 2017-03-08 |
| AU2011336266B2 (en) | 2017-04-06 |
| EP2646043B1 (en) | 2017-02-15 |
| JP2014500265A (ja) | 2014-01-09 |
| BR112013015771A2 (pt) | 2018-11-06 |
| AU2011336266A1 (en) | 2013-06-27 |
| ES2625502T3 (es) | 2017-07-19 |
| EP2646043A1 (en) | 2013-10-09 |
| PT2646043T (pt) | 2017-05-09 |
| MX2013006254A (es) | 2013-10-30 |
| CN103249424A (zh) | 2013-08-14 |
| WO2012075494A1 (en) | 2012-06-07 |
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