JP6093307B2 - ウイルス感染の治療および予防のための新規シクロスポリン誘導体 - Google Patents

ウイルス感染の治療および予防のための新規シクロスポリン誘導体 Download PDF

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JP6093307B2
JP6093307B2 JP2013542244A JP2013542244A JP6093307B2 JP 6093307 B2 JP6093307 B2 JP 6093307B2 JP 2013542244 A JP2013542244 A JP 2013542244A JP 2013542244 A JP2013542244 A JP 2013542244A JP 6093307 B2 JP6093307 B2 JP 6093307B2
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hydroxy
sar
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methyl
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Japanese (ja)
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JP2014500265A5 (enExample
JP2014500265A (ja
Inventor
ス，ズァン
ロン，ゼンギュ
ファン，ゼンニァン
ヤン，スイゾウ
Original Assignee
エス アンド ティー グローバル インク．
エス アンド ティー グローバル インク．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2013542244A 2010-12-03 2011-12-05 ウイルス感染の治療および予防のための新規シクロスポリン誘導体 Expired - Fee Related JP6093307B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41932610P 2010-12-03 2010-12-03
US61/419,326 2010-12-03
PCT/US2011/063295 WO2012075494A1 (en) 2010-12-03 2011-12-05 Novel cyclosporin derivatives for the treatment and prevention of a viral infection

Publications (3)

Publication Number Publication Date
JP2014500265A JP2014500265A (ja) 2014-01-09
JP2014500265A5 JP2014500265A5 (enExample) 2015-02-05
JP6093307B2 true JP6093307B2 (ja) 2017-03-08

Family

ID=46172312

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013542244A Expired - Fee Related JP6093307B2 (ja) 2010-12-03 2011-12-05 ウイルス感染の治療および予防のための新規シクロスポリン誘導体

Country Status (13)

Country Link
EP (1) EP2646043B1 (enExample)
JP (1) JP6093307B2 (enExample)
CN (1) CN103249424B (enExample)
AU (1) AU2011336266B2 (enExample)
BR (1) BR112013015771A2 (enExample)
CA (1) CA2819608C (enExample)
DK (1) DK2646043T3 (enExample)
ES (1) ES2625502T3 (enExample)
MX (1) MX350746B (enExample)
PT (1) PT2646043T (enExample)
RU (1) RU2601742C2 (enExample)
WO (1) WO2012075494A1 (enExample)
ZA (1) ZA201303610B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107007815A (zh) 2010-07-16 2017-08-04 美国科技环球有限公司 新颖的环孢霉素a衍生物在病毒感染的治疗和预防中的应用
WO2012021796A2 (en) 2010-08-12 2012-02-16 S&T Global, Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection
MX2013004062A (es) 2010-10-12 2013-07-22 Allergan Inc Analogos de ciclosporina.
RU2013119869A (ru) * 2010-10-12 2014-11-20 Аллерган, Инк. Аналоги циклоспорина
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
CA2874548A1 (en) 2012-06-01 2013-12-05 Allergan, Inc. Cyclosporin a analogs
EP2900684A2 (en) * 2012-09-29 2015-08-05 Novartis AG Cyclic peptides and use as medicines
EP2968445A4 (en) * 2013-03-15 2016-10-12 Zhuang Su NOVEL CYCLOSPORINE DERIVATIVES AND USES THEREOF
WO2016112321A1 (en) 2015-01-08 2016-07-14 Allergan, Inc. Cyclosporin derivatives wherein the mebmt sidechain has been cyclized
JP2019518745A (ja) 2016-05-17 2019-07-04 エス アンド ティー グローバル インク． 新規シクロスポリン誘導体及びその使用
EP3914655B1 (en) 2019-01-24 2025-04-23 Agfa Nv Radiation curable inkjet inks for interior decoration
EP3686252A1 (en) 2019-01-24 2020-07-29 Agfa-Gevaert Nv Radiation curable inkjet ink for manufacturing printed circuit boards
US12226446B2 (en) 2019-10-11 2025-02-18 Waterstone Pharmaceuticals(Wuhan) Co., Ltd. WS-635 uses thereof in medicine
AU2021256222A1 (en) * 2020-04-15 2022-10-06 Farsight Medical Technology (Shanghai) Co., Ltd. Prevention and treatment of organ injuries
WO2021243658A1 (en) * 2020-06-04 2021-12-09 Waterstone Pharmaceuticals (Wuhan) Co., Ltd. Treatment or prevention of coronaviridae infection

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (en) * 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
NZ315324A (en) * 1995-07-17 1999-10-28 Chem Ag C Cyclosporin derivatives with anti-hiv effect
JP2008514702A (ja) * 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド 新規シクロスポリン類似体およびそれらの薬学的使用
SI1802650T1 (sl) * 2004-10-01 2012-03-30 Scynexis Inc Eter in tioeter substituirani ciklosporinski derivati za zdravljenje in preventivo pred infekcijami s hepatitisom c
ZA200703157B (en) * 2004-10-01 2008-08-27 Scynexis Inc 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
US7196161B2 (en) * 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
AU2010203656A1 (en) * 2009-01-07 2011-07-21 Scynexis, Inc. Cyclosporine derivative for use in the treatment of HCV and HIV infection
EP2391376A4 (en) * 2009-01-30 2012-08-01 Enanta Pharm Inc ANALOGUES OF CYCLOSPORIN FOR PREVENTING OR TREATING HEPATITIS C INFECTION
WO2012021796A2 (en) * 2010-08-12 2012-02-16 S&T Global, Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection

Also Published As

Publication number Publication date
MX2013006254A (es) 2013-10-30
RU2601742C2 (ru) 2016-11-10
EP2646043B1 (en) 2017-02-15
AU2011336266A1 (en) 2013-06-27
CN103249424B (zh) 2016-08-10
AU2011336266B2 (en) 2017-04-06
CA2819608C (en) 2020-03-31
MX350746B (es) 2017-09-14
JP2014500265A (ja) 2014-01-09
EP2646043A1 (en) 2013-10-09
DK2646043T3 (da) 2017-05-22
BR112013015771A2 (pt) 2018-11-06
CA2819608A1 (en) 2012-06-07
RU2013130256A (ru) 2015-01-10
PT2646043T (pt) 2017-05-09
EP2646043A4 (en) 2014-05-28
CN103249424A (zh) 2013-08-14
ES2625502T3 (es) 2017-07-19
ZA201303610B (en) 2014-07-30
WO2012075494A1 (en) 2012-06-07

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