JP6093307B2 - ウイルス感染の治療および予防のための新規シクロスポリン誘導体 - Google Patents

ウイルス感染の治療および予防のための新規シクロスポリン誘導体 Download PDF

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JP6093307B2
JP6093307B2 JP2013542244A JP2013542244A JP6093307B2 JP 6093307 B2 JP6093307 B2 JP 6093307B2 JP 2013542244 A JP2013542244 A JP 2013542244A JP 2013542244 A JP2013542244 A JP 2013542244A JP 6093307 B2 JP6093307 B2 JP 6093307B2
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alkyl
hydroxy
sar
optionally substituted
methyl
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Japanese (ja)
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JP2014500265A5 (enExample
JP2014500265A (ja
Inventor
ス，ズァン
ロン，ゼンギュ
ファン，ゼンニァン
ヤン，スイゾウ
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エス アンド ティー グローバル インク．
エス アンド ティー グローバル インク．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2013542244A 2010-12-03 2011-12-05 ウイルス感染の治療および予防のための新規シクロスポリン誘導体 Expired - Fee Related JP6093307B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41932610P 2010-12-03 2010-12-03
US61/419,326 2010-12-03
PCT/US2011/063295 WO2012075494A1 (en) 2010-12-03 2011-12-05 Novel cyclosporin derivatives for the treatment and prevention of a viral infection

Publications (3)

Publication Number Publication Date
JP2014500265A JP2014500265A (ja) 2014-01-09
JP2014500265A5 JP2014500265A5 (enExample) 2015-02-05
JP6093307B2 true JP6093307B2 (ja) 2017-03-08

Family

ID=46172312

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013542244A Expired - Fee Related JP6093307B2 (ja) 2010-12-03 2011-12-05 ウイルス感染の治療および予防のための新規シクロスポリン誘導体

Country Status (13)

Country Link
EP (1) EP2646043B1 (enExample)
JP (1) JP6093307B2 (enExample)
CN (1) CN103249424B (enExample)
AU (1) AU2011336266B2 (enExample)
BR (1) BR112013015771A2 (enExample)
CA (1) CA2819608C (enExample)
DK (1) DK2646043T3 (enExample)
ES (1) ES2625502T3 (enExample)
MX (1) MX350746B (enExample)
PT (1) PT2646043T (enExample)
RU (1) RU2601742C2 (enExample)
WO (1) WO2012075494A1 (enExample)
ZA (1) ZA201303610B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012009715A2 (en) 2010-07-16 2012-01-19 S&T Global Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection
CN103153330B (zh) 2010-08-12 2017-08-18 美国科技环球有限公司 新的环孢霉素衍生物在病毒感染的治疗和预防中的应用
WO2012051194A1 (en) 2010-10-12 2012-04-19 Allergan, Inc. Cyclosporin analogs
AU2011316689B2 (en) * 2010-10-12 2016-07-14 Allergan, Inc. Cyclosporin analogs
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
JP2015519368A (ja) 2012-06-01 2015-07-09 アラーガン インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンａ類似体
JP2015532277A (ja) * 2012-09-29 2015-11-09 ノバルティス アーゲー 環状ペプチドおよび医薬としてのその使用
CN105960246A (zh) * 2013-03-15 2016-09-21 美国科技环球有限公司 新型环孢菌素衍生物及其用途
WO2016112321A1 (en) 2015-01-08 2016-07-14 Allergan, Inc. Cyclosporin derivatives wherein the mebmt sidechain has been cyclized
CN118324867A (zh) 2016-05-17 2024-07-12 美国科技环球有限公司 新型环孢菌素衍生物及其用途
WO2020152037A1 (en) 2019-01-24 2020-07-30 Agfa Nv Radiation curable inkjet inks for interior decoration
EP3686252A1 (en) 2019-01-24 2020-07-29 Agfa-Gevaert Nv Radiation curable inkjet ink for manufacturing printed circuit boards
CA3128410A1 (en) * 2019-10-11 2021-04-15 Waterstone Pharmaceuticals (Wuhan) Co., Ltd. Ws-635 uses thereof in medicine
JP2023521161A (ja) * 2020-04-15 2023-05-23 ファーサイト メディカル テクノロジー （シャンハイ） カンパニー リミテッド 臓器傷害の予防及び処置
EP4161557A4 (en) * 2020-06-04 2024-04-24 Waterstone Pharmaceuticals (Wuhan) Co., Ltd. TREATMENT OR PREVENTION OF CORONAVIRIDAE INFECTION

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (en) * 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
CN1141317C (zh) * 1995-07-17 2004-03-10 碳化学公司 有抗人体免疫缺损病毒作用的环孢菌素衍生物
WO2006039164A2 (en) * 2004-09-29 2006-04-13 Amr Technology, Inc. Novel cyclosporin analogues and their pharmaceutical uses
CA2583494C (en) * 2004-10-01 2014-01-21 Scynexis, Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis c infection
US7196161B2 (en) * 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
CN101068829B (zh) * 2004-10-01 2012-05-30 西尼克斯公司 用于治疗和预防丙型肝炎病毒感染的3-醚和3-硫醚取代的环孢菌素衍生物
US20100173837A1 (en) * 2009-01-07 2010-07-08 Scynexis, Inc. Dosing forms and regimens comprising 3-[(r)-2-(n,n-dimethylamino)ethylthio-sar]-4-(gammahydroxymethylleucine)cyclosporine
US8367618B2 (en) * 2009-01-30 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis C infection
CN103153330B (zh) * 2010-08-12 2017-08-18 美国科技环球有限公司 新的环孢霉素衍生物在病毒感染的治疗和预防中的应用

Also Published As

Publication number Publication date
MX2013006254A (es) 2013-10-30
RU2601742C2 (ru) 2016-11-10
CN103249424A (zh) 2013-08-14
ES2625502T3 (es) 2017-07-19
AU2011336266B2 (en) 2017-04-06
MX350746B (es) 2017-09-14
BR112013015771A2 (pt) 2018-11-06
PT2646043T (pt) 2017-05-09
CA2819608A1 (en) 2012-06-07
JP2014500265A (ja) 2014-01-09
RU2013130256A (ru) 2015-01-10
DK2646043T3 (da) 2017-05-22
CN103249424B (zh) 2016-08-10
WO2012075494A1 (en) 2012-06-07
CA2819608C (en) 2020-03-31
AU2011336266A1 (en) 2013-06-27
EP2646043A4 (en) 2014-05-28
ZA201303610B (en) 2014-07-30
EP2646043B1 (en) 2017-02-15
EP2646043A1 (en) 2013-10-09

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