ZA201104396B - "substituted isoidoles as bace inhibitors and their use (new compounds 578)" - Google Patents

"substituted isoidoles as bace inhibitors and their use (new compounds 578)"

Info

Publication number
ZA201104396B
ZA201104396B ZA2011/04396A ZA201104396A ZA201104396B ZA 201104396 B ZA201104396 B ZA 201104396B ZA 2011/04396 A ZA2011/04396 A ZA 2011/04396A ZA 201104396 A ZA201104396 A ZA 201104396A ZA 201104396 B ZA201104396 B ZA 201104396B
Authority
ZA
South Africa
Prior art keywords
isoidoles
substituted
new compounds
bace inhibitors
bace
Prior art date
Application number
ZA2011/04396A
Other languages
English (en)
Inventor
Jorg Holenz
Karin Kolmodin
Laszlo Rakos
Peter Soderman
Berg Stefan Von
Sofia Karlstrom
Johan Lindstrom
Didier Rotticci
Britt-Marie Swahn
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42170158&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA201104396(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ZA201104396B publication Critical patent/ZA201104396B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA2011/04396A 2008-11-14 2011-06-13 "substituted isoidoles as bace inhibitors and their use (new compounds 578)" ZA201104396B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11463408P 2008-11-14 2008-11-14
US13976708P 2008-12-22 2008-12-22
US22165309P 2009-06-30 2009-06-30
PCT/SE2009/051295 WO2010056196A1 (en) 2008-11-14 2009-11-13 New compounds 578

Publications (1)

Publication Number Publication Date
ZA201104396B true ZA201104396B (en) 2012-03-28

Family

ID=42170158

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2011/04396A ZA201104396B (en) 2008-11-14 2011-06-13 "substituted isoidoles as bace inhibitors and their use (new compounds 578)"

Country Status (24)

Country Link
US (2) US8030500B2 (en:Method)
EP (1) EP2367814A4 (en:Method)
JP (1) JP2012508734A (en:Method)
KR (1) KR20110091540A (en:Method)
CN (1) CN102282140A (en:Method)
AR (1) AR074341A1 (en:Method)
AU (1) AU2009314664A1 (en:Method)
BR (1) BRPI0921879A2 (en:Method)
CA (1) CA2743938A1 (en:Method)
CL (1) CL2011001098A1 (en:Method)
CO (1) CO6362004A2 (en:Method)
CR (1) CR20110255A (en:Method)
CU (1) CU20110106A7 (en:Method)
DO (1) DOP2011000138A (en:Method)
EA (1) EA201190020A1 (en:Method)
EC (1) ECSP11011051A (en:Method)
IL (1) IL212590A0 (en:Method)
MX (1) MX2011004918A (en:Method)
NI (1) NI201100099A (en:Method)
PE (1) PE20110875A1 (en:Method)
TW (1) TW201020244A (en:Method)
UY (1) UY32241A (en:Method)
WO (1) WO2010056196A1 (en:Method)
ZA (1) ZA201104396B (en:Method)

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JP5766198B2 (ja) 2010-10-29 2015-08-19 塩野義製薬株式会社 縮合アミノジヒドロピリミジン誘導体
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Also Published As

Publication number Publication date
UY32241A (es) 2010-06-30
IL212590A0 (en) 2011-07-31
EP2367814A4 (en) 2012-07-04
US20100125082A1 (en) 2010-05-20
CN102282140A (zh) 2011-12-14
MX2011004918A (es) 2011-05-30
EP2367814A1 (en) 2011-09-28
US20110319426A1 (en) 2011-12-29
CU20110106A7 (es) 2012-01-31
BRPI0921879A2 (pt) 2018-10-16
CL2011001098A1 (es) 2012-02-24
WO2010056196A1 (en) 2010-05-20
TW201020244A (en) 2010-06-01
US8030500B2 (en) 2011-10-04
AU2009314664A1 (en) 2011-06-23
KR20110091540A (ko) 2011-08-11
CR20110255A (es) 2011-07-04
ECSP11011051A (es) 2011-06-30
AR074341A1 (es) 2011-01-12
CO6362004A2 (es) 2012-01-20
EA201190020A1 (ru) 2012-02-28
DOP2011000138A (es) 2011-06-30
CA2743938A1 (en) 2010-05-20
NI201100099A (es) 2012-03-19
PE20110875A1 (es) 2012-01-11
JP2012508734A (ja) 2012-04-12

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