ZA200902940B - Substituted pyrazole and triazole compounds as KSP inhibitors - Google Patents
Substituted pyrazole and triazole compounds as KSP inhibitorsInfo
- Publication number
- ZA200902940B ZA200902940B ZA200902940A ZA200902940A ZA200902940B ZA 200902940 B ZA200902940 B ZA 200902940B ZA 200902940 A ZA200902940 A ZA 200902940A ZA 200902940 A ZA200902940 A ZA 200902940A ZA 200902940 B ZA200902940 B ZA 200902940B
- Authority
- ZA
- South Africa
- Prior art keywords
- triazole compounds
- substituted pyrazole
- ksp inhibitors
- ksp
- inhibitors
- Prior art date
Links
- NOIXNOMHHWGUTG-UHFFFAOYSA-N 2-[[4-[4-pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline Chemical compound C=1C=C(OCC=2N=C3C=CC=CC3=CC=2)C=CC=1C1=NN(CC(F)(F)F)C=C1C1=CC=NC=C1 NOIXNOMHHWGUTG-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- -1 triazole compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85896406P | 2006-11-13 | 2006-11-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200902940B true ZA200902940B (en) | 2010-05-26 |
Family
ID=39144618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200902940A ZA200902940B (en) | 2006-11-13 | 2009-04-29 | Substituted pyrazole and triazole compounds as KSP inhibitors |
Country Status (32)
Country | Link |
---|---|
US (2) | US8129358B2 (ko) |
EP (1) | EP2091926B1 (ko) |
JP (1) | JP5264755B2 (ko) |
KR (1) | KR20090081020A (ko) |
CN (1) | CN101558049B (ko) |
AR (1) | AR063805A1 (ko) |
AU (1) | AU2007323998B2 (ko) |
BR (1) | BRPI0719002A2 (ko) |
CA (1) | CA2668661A1 (ko) |
CL (1) | CL2007003272A1 (ko) |
CO (1) | CO6382171A2 (ko) |
CR (1) | CR10787A (ko) |
DO (1) | DOP2009000106A (ko) |
EA (1) | EA017748B1 (ko) |
EC (1) | ECSP099326A (ko) |
ES (1) | ES2557478T3 (ko) |
GE (1) | GEP20125389B (ko) |
GT (1) | GT200900122A (ko) |
HN (1) | HN2009000968A (ko) |
IL (1) | IL198471A0 (ko) |
MA (1) | MA30959B1 (ko) |
MX (1) | MX2009005071A (ko) |
NI (1) | NI200900084A (ko) |
NO (1) | NO20092226L (ko) |
NZ (1) | NZ576640A (ko) |
PE (1) | PE20081169A1 (ko) |
SM (1) | SMP200900045B (ko) |
TN (1) | TN2009000178A1 (ko) |
TW (1) | TW200831480A (ko) |
UA (1) | UA97256C2 (ko) |
WO (1) | WO2008063912A1 (ko) |
ZA (1) | ZA200902940B (ko) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8129358B2 (en) * | 2006-11-13 | 2012-03-06 | Novartis Ag | Substituted pyrazole and triazole compounds as KSP inhibitors |
NZ577727A (en) * | 2007-01-05 | 2012-03-30 | Novartis Ag | Imidazole derivatives as kinesin spindle protein inhibitors (eg-5) |
EA201201404A1 (ru) | 2010-04-15 | 2013-04-30 | Новартис Аг | Триазолы как ингибиторы кбв (кинезин-белок веретена) |
CN103153970A (zh) * | 2010-04-15 | 2013-06-12 | 诺瓦提斯公司 | 作为ksp抑制剂的*唑和噻唑化合物 |
EP2928472B1 (en) * | 2012-12-05 | 2018-05-02 | Merck Sharp & Dohme Corp. | Process for making reverse transcriptase inhibitors |
JP2016516035A (ja) * | 2013-03-15 | 2016-06-02 | ノバルティス アーゲー | 細胞増殖阻害剤およびそれらのコンジュゲート |
US9498540B2 (en) | 2013-03-15 | 2016-11-22 | Novartis Ag | Cell proliferation inhibitors and conjugates thereof |
ES2759976T3 (es) | 2013-12-04 | 2020-05-12 | Merck Sharp & Dohme | Proceso para fabricar inhibidores de la transcriptasa inversa |
US10786578B2 (en) | 2014-08-05 | 2020-09-29 | Novartis Ag | CKIT antibody drug conjugates |
EP3386973B1 (en) * | 2015-12-11 | 2020-08-12 | Syngenta Participations AG | Pesticidally active 1,2,4-triazole derivatives |
EP4085056A1 (en) | 2020-01-03 | 2022-11-09 | Berg LLC | Polycyclic amides as ube2k modulators for treating cancer |
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US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4501728A (en) * | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
US5023252A (en) * | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
US4837028A (en) * | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5011472A (en) * | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
US5185450A (en) * | 1991-02-19 | 1993-02-09 | University Of South Florida | Tetrazolium compounds for cell viability assays |
AUPP042397A0 (en) * | 1997-11-18 | 1997-12-11 | Fujisawa Pharmaceutical Co., Ltd. | 5-arylpyrazole compounds |
JP2002541146A (ja) | 1999-04-02 | 2002-12-03 | ニューロゲン コーポレイション | アリールおよびヘテロアリール融合のアミノアルキル−イミダゾール誘導体および糖尿病薬としてのその使用 |
US6545004B1 (en) * | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
IL149164A0 (en) | 1999-10-27 | 2002-11-10 | Cytokinetics Inc | Methods and compositions utilizing quinazolinones |
WO2002028839A1 (en) | 2000-10-06 | 2002-04-11 | Neurogen Corporation | Benzimidazole and indole derivatives as crf receptor modulators |
US20040132830A1 (en) | 2001-01-19 | 2004-07-08 | Finer Jeffrey T | Triphenylmethane kinesin inhibitors |
US6992082B2 (en) | 2001-01-19 | 2006-01-31 | Cytokinetics, Inc. | Phenothiazine kinesin inhibitors |
CA2465491A1 (en) | 2001-11-07 | 2003-05-15 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
CA2466033A1 (en) | 2001-11-08 | 2003-05-15 | The University Of Chicago | Method of treating disorder related to high cholesterol concentration |
WO2003043995A1 (en) | 2001-11-20 | 2003-05-30 | Cytokinetics, Inc. | Process for the racemization of chiral quinazolinones |
ATE447577T1 (de) | 2001-12-06 | 2009-11-15 | Merck & Co Inc | Mitotische kinesin-hemmer |
DE60232994D1 (de) | 2001-12-06 | 2009-08-27 | Merck & Co Inc | Inhibitoren von mitotischem kinesin |
ATE424388T1 (de) | 2001-12-06 | 2009-03-15 | Merck & Co Inc | Mitotische kinesinhemmer |
WO2003050064A2 (en) | 2001-12-06 | 2003-06-19 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
WO2003050122A2 (en) | 2001-12-06 | 2003-06-19 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
EP1461027A4 (en) * | 2001-12-07 | 2005-09-07 | Univ Virginia Commonwealth | TREATMENT OF NEOPLASIA |
EP1465888A2 (en) | 2002-01-10 | 2004-10-13 | Neurogen Corporation | Melanin concentrating hormone receptor ligands: substituted benzoimidazole analogues |
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US7009049B2 (en) | 2002-02-15 | 2006-03-07 | Cytokinetics, Inc. | Syntheses of quinazolinones |
WO2003079973A2 (en) | 2002-03-08 | 2003-10-02 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
RU2004135554A (ru) | 2002-05-09 | 2006-01-20 | Цитокинетикс, Инк. (Us) | Пиримидиноны, композиции на их основе и способы их использования |
JP2005530785A (ja) | 2002-05-09 | 2005-10-13 | サイトキネティクス・インコーポレーテッド | 化合物、組成物、及び方法 |
WO2004026226A2 (en) | 2002-05-10 | 2004-04-01 | Cytokinetics, Inc. | Compounds, compositions and methods |
EP1509507A4 (en) | 2002-05-23 | 2006-09-13 | Merck & Co Inc | INHIBITORS OF MITOTIC KINESIN |
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US7301028B2 (en) | 2002-06-14 | 2007-11-27 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
GB0214139D0 (en) * | 2002-06-19 | 2002-07-31 | Glaxo Group Ltd | Chemical compounds |
JP2005537257A (ja) | 2002-07-08 | 2005-12-08 | メルク エンド カムパニー インコーポレーテッド | 有糸分裂キネシン結合部位 |
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JP2006501201A (ja) | 2002-07-23 | 2006-01-12 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
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EP1554265A4 (en) | 2002-09-13 | 2008-05-07 | Cytokinetics Inc | COMPOSITIONS, COMPOSITIONS AND M THODES |
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ATE419249T1 (de) * | 2004-04-06 | 2009-01-15 | Novartis Vaccines & Diagnostic | Inhibitoren von mitotischem kinesin |
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US8129358B2 (en) * | 2006-11-13 | 2012-03-06 | Novartis Ag | Substituted pyrazole and triazole compounds as KSP inhibitors |
-
2007
- 2007-11-08 US US12/312,389 patent/US8129358B2/en not_active Expired - Fee Related
- 2007-11-08 KR KR1020097012214A patent/KR20090081020A/ko not_active Application Discontinuation
- 2007-11-08 WO PCT/US2007/084154 patent/WO2008063912A1/en active Application Filing
- 2007-11-08 UA UAA200904556A patent/UA97256C2/ru unknown
- 2007-11-08 EP EP07844993.1A patent/EP2091926B1/en active Active
- 2007-11-08 BR BRPI0719002-6A patent/BRPI0719002A2/pt not_active IP Right Cessation
- 2007-11-08 ES ES07844993.1T patent/ES2557478T3/es active Active
- 2007-11-08 NZ NZ576640A patent/NZ576640A/en not_active IP Right Cessation
- 2007-11-08 AU AU2007323998A patent/AU2007323998B2/en not_active Ceased
- 2007-11-08 CN CN2007800456741A patent/CN101558049B/zh not_active Expired - Fee Related
- 2007-11-08 US US11/937,426 patent/US7902240B2/en not_active Expired - Fee Related
- 2007-11-08 EA EA200900631A patent/EA017748B1/ru not_active IP Right Cessation
- 2007-11-08 JP JP2009536490A patent/JP5264755B2/ja not_active Expired - Fee Related
- 2007-11-08 GE GEAP200711253A patent/GEP20125389B/en unknown
- 2007-11-08 MX MX2009005071A patent/MX2009005071A/es active IP Right Grant
- 2007-11-08 CA CA002668661A patent/CA2668661A1/en not_active Abandoned
- 2007-11-12 TW TW096142719A patent/TW200831480A/zh unknown
- 2007-11-13 AR ARP070105052A patent/AR063805A1/es unknown
- 2007-11-13 PE PE2007001561A patent/PE20081169A1/es not_active Application Discontinuation
- 2007-11-13 CL CL200703272A patent/CL2007003272A1/es unknown
-
2009
- 2009-04-29 ZA ZA200902940A patent/ZA200902940B/xx unknown
- 2009-04-30 IL IL198471A patent/IL198471A0/en unknown
- 2009-05-08 CR CR10787A patent/CR10787A/es not_active Application Discontinuation
- 2009-05-08 TN TNP2009000178A patent/TN2009000178A1/fr unknown
- 2009-05-11 DO DO2009000106A patent/DOP2009000106A/es unknown
- 2009-05-12 CO CO09048059A patent/CO6382171A2/es not_active Application Discontinuation
- 2009-05-12 GT GT200900122A patent/GT200900122A/es unknown
- 2009-05-13 EC EC2009009326A patent/ECSP099326A/es unknown
- 2009-05-13 HN HN2009000968A patent/HN2009000968A/es unknown
- 2009-05-13 NI NI200900084A patent/NI200900084A/es unknown
- 2009-06-01 MA MA31938A patent/MA30959B1/fr unknown
- 2009-06-09 NO NO20092226A patent/NO20092226L/no not_active Application Discontinuation
- 2009-06-10 SM SM200900045T patent/SMP200900045B/it unknown
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