ZA200902477B - Di-fluoro containing compounds as cysteine protease inhibitors - Google Patents
Di-fluoro containing compounds as cysteine protease inhibitorsInfo
- Publication number
- ZA200902477B ZA200902477B ZA200902477A ZA200902477A ZA200902477B ZA 200902477 B ZA200902477 B ZA 200902477B ZA 200902477 A ZA200902477 A ZA 200902477A ZA 200902477 A ZA200902477 A ZA 200902477A ZA 200902477 B ZA200902477 B ZA 200902477B
- Authority
- ZA
- South Africa
- Prior art keywords
- containing compounds
- protease inhibitors
- cysteine protease
- fluoro containing
- fluoro
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000002852 cysteine proteinase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84958706P | 2006-10-04 | 2006-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200902477B true ZA200902477B (en) | 2010-08-25 |
Family
ID=39145436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200902477A ZA200902477B (en) | 2006-10-04 | 2007-10-03 | Di-fluoro containing compounds as cysteine protease inhibitors |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7781487B2 (ko) |
| EP (1) | EP2079683B1 (ko) |
| JP (1) | JP5351030B2 (ko) |
| KR (2) | KR101486763B1 (ko) |
| AU (1) | AU2007303200B2 (ko) |
| CA (1) | CA2664878A1 (ko) |
| DK (1) | DK2079683T3 (ko) |
| EA (1) | EA022130B1 (ko) |
| ES (1) | ES2535603T3 (ko) |
| IL (1) | IL197965A (ko) |
| MX (1) | MX2009003563A (ko) |
| NZ (1) | NZ576105A (ko) |
| PT (1) | PT2079683E (ko) |
| TW (1) | TWI483720B (ko) |
| WO (1) | WO2008042968A2 (ko) |
| ZA (1) | ZA200902477B (ko) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7893112B2 (en) | 2006-10-04 | 2011-02-22 | Virobay, Inc. | Di-fluoro containing compounds as cysteine protease inhibitors |
| WO2009123623A1 (en) * | 2008-04-01 | 2009-10-08 | Virobay, Inc. | Di-fluoro containing compounds as cysteine protease inhibitors |
| CN102264695B (zh) * | 2008-11-13 | 2014-11-05 | 维罗贝股份有限公司 | 作为半胱氨酸蛋白酶抑制剂的含卤代烷基化合物 |
| US8324417B2 (en) * | 2009-08-19 | 2012-12-04 | Virobay, Inc. | Process for the preparation of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid and alkyl esters and acid salts thereof |
| WO2020201572A1 (en) | 2019-04-05 | 2020-10-08 | Université De Bretagne Occidentale | Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3599287B2 (ja) | 1993-04-28 | 2004-12-08 | 三菱化学株式会社 | スルホンアミド誘導体 |
| PL202226B1 (pl) | 1997-11-05 | 2009-06-30 | Novartis Ag | Nitryl dipeptydowy, jego zastosowanie lecznicze i zawierająca go kompozycja farmaceutyczna |
| US6685572B2 (en) | 1998-07-22 | 2004-02-03 | Ntn Corporation | Power transmission mechanism |
| US6395897B1 (en) * | 1999-03-02 | 2002-05-28 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nitrile compounds useful as reversible inhibitors of #9 cathepsin 5 |
| JP2002539192A (ja) | 1999-03-15 | 2002-11-19 | アクシス・ファーマシューティカルズ・インコーポレイテッド | プロテアーゼ阻害剤としての新規な化合物及び組成物 |
| AU779177B2 (en) * | 1999-03-15 | 2005-01-13 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions as protease inhibitors |
| EP1218372B1 (en) | 1999-09-13 | 2003-07-02 | Boehringer Ingelheim Pharmaceuticals, Inc. | Novel heterocyclic compounds useful as reversible inhibitors of cysteine proteases |
| US6420364B1 (en) * | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
| US6492362B1 (en) | 1999-09-16 | 2002-12-10 | Axys Pharmaceuticals, Inc. | Compounds and compositions as cathepsin S inhibitors |
| AU779855B2 (en) | 2000-01-06 | 2005-02-17 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions as protease inhibitors |
| WO2001068645A2 (en) | 2000-03-15 | 2001-09-20 | Axys Pharmaceuticals, Inc. | N-cyanomethylcarboxamides and their use as protease inhibitors |
| AU2002254099B2 (en) | 2001-03-02 | 2006-07-06 | Axys Pharmaceuticals, Inc. | Cathepsin cysteine protease inhibitors |
| SE521652C2 (sv) | 2001-03-15 | 2003-11-25 | Canag Diagnostics Ab | En skivepitelcellcancerrelaterad fusionsgen och motsvarande fusionsprotein |
| NZ528944A (en) | 2001-06-01 | 2007-09-28 | Axys Pharm Inc | Chemical compounds and pharmaceutical compositions as cathepsin S inhibitors |
| CN1324008C (zh) | 2001-09-14 | 2007-07-04 | 安万特药物公司 | 作为组织蛋白酶抑制剂的新化合物和组合物 |
| EP1434769A2 (en) | 2001-10-02 | 2004-07-07 | Boehringer Ingelheim Pharmaceuticals Inc. | Compounds useful as reversible inhibitors of cysteine proteases |
| WO2003037892A1 (en) * | 2001-10-29 | 2003-05-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cysteine proteases |
| WO2003041649A2 (en) * | 2001-11-13 | 2003-05-22 | Merck Frosst Canada & Co. | Cyanoalkylamino derivatives as protease inhibitors |
| PT1482924E (pt) | 2002-03-05 | 2008-08-27 | Axys Pharm Inc | Inibidores de proteases da cisteína catepsina |
| JP2006506326A (ja) | 2002-05-14 | 2006-02-23 | アキシーズ ファーマシューティカルズ インク． | システインプロテアーゼ阻害剤 |
| US7101880B2 (en) * | 2002-06-24 | 2006-09-05 | Schering Aktiengesellschaft | Peptidic compounds as cysteine protease inhibitors |
| WO2004033445A1 (en) | 2002-10-08 | 2004-04-22 | Merck Frosst Canada & Co. | 4-amino-azepan-3-one compounds as cathepsin k inhibitors useful in the treatment of osteoporosis |
| US7326719B2 (en) | 2003-03-13 | 2008-02-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Cathepsin S inhibitors |
| CA2526694A1 (en) | 2003-06-04 | 2004-12-16 | John W. Patterson | Amidino compounds as cysteine protease inhibitors |
| EP1660436A4 (en) | 2003-08-27 | 2006-11-22 | Merck Frosst Canada Ltd | cathepsin inhibitors |
| JP2007505919A (ja) | 2003-09-18 | 2007-03-15 | アクシス・ファーマシューティカルズ・インコーポレイテッド | システイン・プロテアーゼ阻害剤としてのハロアルキル含有化合物 |
| SG146658A1 (en) | 2003-09-18 | 2008-10-30 | Schering Ag | Haloalkyl containing compounds as cysteine protease inhibitors |
| RU2346943C2 (ru) * | 2003-10-24 | 2009-02-20 | Авентис Фармасьютикалз Инк. | Новые соединения и композиции в качестве ингибиторов катепсина |
| JP2007513972A (ja) | 2003-12-11 | 2007-05-31 | アクシス・ファーマシューティカルズ・インコーポレイテッド | 低分子治療剤または生物製剤の投与によって引き起こされる免疫応答を治療するためのカテプシンｓインヒビターの使用 |
| CN100548986C (zh) * | 2003-12-12 | 2009-10-14 | 默克弗罗斯特加拿大有限公司 | 组织蛋白酶半胱氨酸蛋白酶抑制剂 |
| EP1697355A2 (en) | 2003-12-23 | 2006-09-06 | Axys Pharmaceuticals, Inc. | Amidino compounds as cysteine protease inhibitors |
| JP2007519744A (ja) | 2004-01-30 | 2007-07-19 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | システインプロテアーゼインヒビターとしてのシリナン化合物。 |
| CN101068783A (zh) | 2004-09-17 | 2007-11-07 | 拜耳先灵制药有限公司 | 用于制备半胱氨酸蛋白酶抑制剂的方法和中间体 |
| AR055283A1 (es) * | 2004-11-23 | 2007-08-15 | Merck Frosst Canada Ltd | Inhibidores de cisteinproteasa de catepsina |
| US7893112B2 (en) * | 2006-10-04 | 2011-02-22 | Virobay, Inc. | Di-fluoro containing compounds as cysteine protease inhibitors |
-
2007
- 2007-10-03 CA CA002664878A patent/CA2664878A1/en not_active Abandoned
- 2007-10-03 JP JP2009531585A patent/JP5351030B2/ja not_active Expired - Fee Related
- 2007-10-03 DK DK07853752.9T patent/DK2079683T3/en active
- 2007-10-03 KR KR1020097009231A patent/KR101486763B1/ko active IP Right Grant
- 2007-10-03 WO PCT/US2007/080320 patent/WO2008042968A2/en active Application Filing
- 2007-10-03 AU AU2007303200A patent/AU2007303200B2/en not_active Ceased
- 2007-10-03 ES ES07853752.9T patent/ES2535603T3/es active Active
- 2007-10-03 EP EP07853752.9A patent/EP2079683B1/en active Active
- 2007-10-03 PT PT78537529T patent/PT2079683E/pt unknown
- 2007-10-03 ZA ZA200902477A patent/ZA200902477B/xx unknown
- 2007-10-03 KR KR1020147015354A patent/KR101555931B1/ko active IP Right Grant
- 2007-10-03 MX MX2009003563A patent/MX2009003563A/es active IP Right Grant
- 2007-10-03 EA EA200900510A patent/EA022130B1/ru not_active IP Right Cessation
- 2007-10-03 US US11/866,836 patent/US7781487B2/en active Active
- 2007-10-03 NZ NZ576105A patent/NZ576105A/en not_active IP Right Cessation
-
2008
- 2008-04-02 TW TW097112047A patent/TWI483720B/zh not_active IP Right Cessation
-
2009
- 2009-04-05 IL IL197965A patent/IL197965A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008042968A3 (en) | 2008-05-22 |
| IL197965A0 (en) | 2009-12-24 |
| AU2007303200A1 (en) | 2008-04-10 |
| US20080214676A1 (en) | 2008-09-04 |
| KR101486763B1 (ko) | 2015-01-28 |
| WO2008042968A2 (en) | 2008-04-10 |
| NZ576105A (en) | 2012-01-12 |
| TW200942232A (en) | 2009-10-16 |
| JP5351030B2 (ja) | 2013-11-27 |
| CA2664878A1 (en) | 2008-04-10 |
| ES2535603T3 (es) | 2015-05-13 |
| DK2079683T3 (en) | 2015-04-27 |
| AU2007303200B2 (en) | 2011-10-06 |
| EP2079683B1 (en) | 2015-01-21 |
| KR20140112479A (ko) | 2014-09-23 |
| JP2010505872A (ja) | 2010-02-25 |
| IL197965A (en) | 2014-08-31 |
| US7781487B2 (en) | 2010-08-24 |
| PT2079683E (pt) | 2015-05-20 |
| EA022130B1 (ru) | 2015-11-30 |
| MX2009003563A (es) | 2009-04-15 |
| EA200900510A1 (ru) | 2009-08-28 |
| KR101555931B1 (ko) | 2015-09-30 |
| EP2079683A2 (en) | 2009-07-22 |
| KR20090085612A (ko) | 2009-08-07 |
| TWI483720B (zh) | 2015-05-11 |
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