ZA200808491B - High frequency application of neurotoxic component of botulinum toxin - Google Patents
High frequency application of neurotoxic component of botulinum toxinInfo
- Publication number
- ZA200808491B ZA200808491B ZA200808491A ZA200808491A ZA200808491B ZA 200808491 B ZA200808491 B ZA 200808491B ZA 200808491 A ZA200808491 A ZA 200808491A ZA 200808491 A ZA200808491 A ZA 200808491A ZA 200808491 B ZA200808491 B ZA 200808491B
- Authority
- ZA
- South Africa
- Prior art keywords
- high frequency
- botulinum toxin
- frequency application
- neurotoxic component
- neurotoxic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81775606P | 2006-06-29 | 2006-06-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200808491B true ZA200808491B (en) | 2009-11-25 |
Family
ID=38462381
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200808491A ZA200808491B (en) | 2006-06-29 | 2008-10-06 | High frequency application of neurotoxic component of botulinum toxin |
Country Status (17)
Country | Link |
---|---|
US (3) | US8557255B2 (xx) |
EP (2) | EP2484373A1 (xx) |
JP (2) | JP5897784B2 (xx) |
KR (3) | KR20140142377A (xx) |
CN (1) | CN101460190A (xx) |
AR (1) | AR061669A1 (xx) |
AU (1) | AU2007264008B2 (xx) |
BR (1) | BRPI0713061A2 (xx) |
CA (1) | CA2654214C (xx) |
CL (1) | CL2007001911A1 (xx) |
IL (1) | IL195201A (xx) |
MX (1) | MX2009000253A (xx) |
RU (1) | RU2453333C2 (xx) |
TW (1) | TWI519310B (xx) |
UY (1) | UY30450A1 (xx) |
WO (1) | WO2008000490A1 (xx) |
ZA (1) | ZA200808491B (xx) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10792344B2 (en) * | 2006-06-29 | 2020-10-06 | Merz Pharma Gmbh & Co. Kgaa | High frequency application of botulinum toxin therapy |
AR061669A1 (es) * | 2006-06-29 | 2008-09-10 | Merz Pharma Gmbh & Co Kgaa | Aplicacion de alta frecuencia de terapia con toxina botulinica |
EP1985276A1 (en) * | 2007-04-26 | 2008-10-29 | Merz Pharma GmbH & Co. KGaA | Treatment of movement disorders by a combined use of a chemodenervating agent and automated movement therapy |
WO2008145359A1 (en) * | 2007-06-01 | 2008-12-04 | Merz Pharma Gmbh & Co. Kgaa | Process for providing a temperature - stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin |
US7473429B1 (en) * | 2007-07-27 | 2009-01-06 | Renfroe J Ben | Method for treatment of laminitis in animals |
WO2009018546A1 (en) | 2007-08-02 | 2009-02-05 | Medicis Pharmaceutical Corporation | Method of applying an injectable filler |
US20090204101A1 (en) * | 2007-08-20 | 2009-08-13 | Wortzman Mitchell S | Method of applying an injectable filler |
US9161970B2 (en) | 2007-12-12 | 2015-10-20 | Allergan, Inc. | Dermal filler |
US9044477B2 (en) * | 2007-12-12 | 2015-06-02 | Allergan, Inc. | Botulinum toxin formulation |
EP2072057A1 (en) | 2007-12-21 | 2009-06-24 | Merz Pharma GmbH & Co.KGaA | Early administration of Botulinum toxin in the treatment of cerebrovascular event and spinal cord injury |
EP2072039A1 (en) | 2007-12-21 | 2009-06-24 | Merz Pharma GmbH & Co.KGaA | Use of a neurotoxic component of Clostridium botulinum toxin complex to reduce or prevent side effects |
WO2009123174A1 (ja) * | 2008-03-31 | 2009-10-08 | 財団法人化学及血清療法研究所 | A2型ボツリヌス神経毒素製剤 |
AU2009286973B2 (en) | 2008-08-29 | 2014-06-12 | Merz Pharma Gmbh & Co. Kgaa | Clostridial neurotoxins with altered persistency |
EP2161033B1 (en) | 2008-09-09 | 2013-05-01 | Susanne Dr. Grafe | Botulinum toxin to introduce temporal infertiliy in a vertebrate (e.g. human) |
EP2248518B1 (en) * | 2009-04-17 | 2013-01-16 | Merz Pharma GmbH & Co. KGaA | Formulation for stabilizing proteins, peptides or mixtures thereof. |
EP2246065A1 (en) | 2009-04-29 | 2010-11-03 | Merz Pharma GmbH & Co. KGaA | Intrastriatal botulinum toxin therapy |
WO2011023213A1 (en) * | 2009-08-28 | 2011-03-03 | Merz Pharma Gmbh & Co. Kgaa | Modified chemodenervating agents |
CN102666396B (zh) * | 2009-10-21 | 2015-05-13 | 雷文斯治疗公司 | 用于纯化非复合的肉毒杆菌神经毒素的方法和系统 |
KR101134146B1 (ko) * | 2010-05-31 | 2012-04-19 | 메덱스젠 주식회사 | 국소 근마비 효과를 갖는 비확산형 보툴리눔 독소와 그의 정제방법 |
EP2399601A1 (en) | 2010-06-24 | 2011-12-28 | Merz Pharma GmbH & Co. KGaA | Botulinum toxin therapy |
EP2627318B1 (en) | 2010-10-12 | 2017-08-16 | Merz Pharma GmbH & Co. KGaA | Formulation suitable for stabilizing proteins, which is free of mammalian excipients |
RU2454170C1 (ru) * | 2011-02-21 | 2012-06-27 | Федеральное государственное учреждение "Нижегородский научно-исследовательский институт травматологии и ортопедии" Министерства здравоохранения и социального развития Российской Федерации | Способ лечения спастичности мышц у больных с позвоночно-спинномозговой травмой |
WO2014066916A2 (en) | 2012-10-28 | 2014-05-01 | Revance Therapeutics, Inc. | Compositions and methods for safe treatment of rhinitis |
RU2535115C1 (ru) | 2013-05-15 | 2014-12-10 | Бости Трейдинг Лтд | Фармацевтический состав, содержащий нейротоксин ботулина |
KR102272580B1 (ko) * | 2013-07-30 | 2021-07-05 | 메르츠 파마 게엠베하 운트 코. 카가아 | 보툴리눔 독소의 고순도 신경독성 성분의 제조 방법 및 이의 용도 |
WO2015039206A1 (en) * | 2013-09-20 | 2015-03-26 | Mddt Inc. | Diagnosing and treating movement disorders |
EP3046470B1 (en) | 2013-09-20 | 2022-02-23 | MDDT Inc. | Diagnosing and treating movement disorders |
US20170112907A1 (en) * | 2014-06-13 | 2017-04-27 | Merz Pharma Gmbh & Co. Kgaa | Novel uses of recombinant clostridial neurotoxins with decreased duration of effect |
WO2015188942A1 (en) * | 2014-06-13 | 2015-12-17 | Merz Pharma Gmbh & Co. Kgaa | Novel uses of recombinant clostridial neurotoxins with decreased duration of effect |
US11484580B2 (en) | 2014-07-18 | 2022-11-01 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
US20180140685A1 (en) * | 2015-04-24 | 2018-05-24 | Consiglio Nazionale Delle Ricerche | A new therapeutic use of the botulinum neurotoxin serotype a |
US11602303B2 (en) * | 2017-02-10 | 2023-03-14 | Mauricio De Maio Domingos | Methods and systems for preventing, correcting, transforming, and modifying facial, aesthetics, and consulting patients regarding the same |
SG11202107565RA (en) * | 2019-02-21 | 2021-08-30 | Merz Pharma Gmbh & Co Kgaa | Novel uses of botulinum neurotoxin for the treatment of tremor |
RU2721300C2 (ru) * | 2019-10-17 | 2020-05-18 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) | Способ лечения нейрогенной дисфункции мочевого пузыря, проявляющейся функциональной инфравезикальной обструкцией у женщин |
US11738071B2 (en) | 2021-07-12 | 2023-08-29 | Penland Foundation | Treatment of acute and chronic kidney disease |
US10987411B1 (en) | 2019-10-18 | 2021-04-27 | Penland Foundation | Treatment of chronic obstructive pulmonary disease using botulinum toxin |
CA3154363C (en) | 2019-10-18 | 2024-03-05 | Penland Foundation | Use of a botulinum toxin for treating autism and/or tolerance to narcotics |
US10967052B1 (en) | 2019-10-18 | 2021-04-06 | Penland Foundation | Treatment of dyslexia using botulinum toxin |
US11241479B2 (en) | 2019-10-18 | 2022-02-08 | Penland Foundation | Treatment methods using botulinum toxins |
US11925677B2 (en) | 2021-07-12 | 2024-03-12 | Penland Foundation | Treatment of diabetes and chronic pancreatitis using botulinum toxin |
US11090371B1 (en) | 2019-10-18 | 2021-08-17 | Penland Foundation | Treatment of cirrhosis using botulinum toxin |
US10960060B1 (en) | 2019-10-18 | 2021-03-30 | Penland Foundation | Treatment of cardiac arrhythmia using botulinum toxin |
US10960061B1 (en) | 2019-10-18 | 2021-03-30 | Penland Foundation | Treatment of amyotrophic lateral sclerosis using botulinum toxin |
US10973873B1 (en) | 2019-10-18 | 2021-04-13 | Penland Foundation | Treatment of asthma using botulinum toxin |
WO2021137667A1 (ko) * | 2019-12-30 | 2021-07-08 | 주식회사 에이티지씨 | 보툴리눔 신경독소를 포함하는 파킨슨병 치료용 조성물 및 이를 이용한 파킨슨병 치료 방법 |
Family Cites Families (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3888977A (en) * | 1973-02-01 | 1975-06-10 | Murray J Sanders | Modified neurotoxin |
US4932936A (en) * | 1988-01-29 | 1990-06-12 | Regents Of The University Of Minnesota | Method and device for pharmacological control of spasticity |
US5919665A (en) * | 1989-10-31 | 1999-07-06 | Ophidian Pharmaceuticals, Inc. | Vaccine for clostridium botulinum neurotoxin |
GB9120306D0 (en) * | 1991-09-24 | 1991-11-06 | Graham Herbert K | Method and compositions for the treatment of cerebral palsy |
US5562907A (en) * | 1993-05-14 | 1996-10-08 | Arnon; Stephen S. | Method to prevent side-effects and insensitivity to the therapeutic uses of toxins |
EP1099445A3 (en) * | 1993-06-10 | 2001-09-05 | Allergan, Inc. | Treatment of neuromuscular disorders and conditions with different botulinum serotype |
US7037680B2 (en) * | 1993-09-21 | 2006-05-02 | The United States Of America As Represented By The Secretary Of The Army | Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy |
US8557256B2 (en) * | 1993-12-28 | 2013-10-15 | Allergan, Inc. | Treatment for cervical dystonia with the neurotoxic component of a botulinum toxin |
US8187612B2 (en) * | 1993-12-28 | 2012-05-29 | Allergan, Inc. | Use of the neurotoxic component of a botulinum toxin for treating a spastic muscle |
US6974578B1 (en) * | 1993-12-28 | 2005-12-13 | Allergan, Inc. | Method for treating secretions and glands using botulinum toxin |
EP2027872B1 (en) * | 1993-12-28 | 2010-07-14 | Allergan, Inc. | Neurotoxic component of a botulinum toxin for treating tardive dyskinesia |
US5670484A (en) * | 1994-05-09 | 1997-09-23 | Binder; William J. | Method for treatment of skin lesions associated with cutaneous cell-proliferative disorders |
DE69833942T3 (de) * | 1997-07-15 | 2010-06-10 | The Regents Of The University Of Colorado, Boulder | Verwendung einer neurotoxintherapie zur behandlung von prostataerkrankungen |
DK1023410T3 (da) * | 1998-07-07 | 2006-08-14 | Sun Chemical Corp | Kationisk hærdelige litografiske trykfarver med lave indhold af flygtige organiske forbindelser |
AU763410B2 (en) | 1998-09-11 | 2003-07-24 | Gr Intellectual Reserve, Llc | Method and system for biometric recognition based on electric and/or magnetic properties |
TW574036B (en) * | 1998-09-11 | 2004-02-01 | Elan Pharm Inc | Stable liquid compositions of botulinum toxin |
DE19856897A1 (de) * | 1998-12-10 | 2000-06-15 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum zur Unterdrückung von Schnarchgeräuschen |
DE19925739A1 (de) * | 1999-06-07 | 2000-12-21 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum mit einem Botulinum-Neurotoxin |
US6348434B1 (en) * | 1999-07-01 | 2002-02-19 | Basf Aktiengesellschaft | Herbicidal emulsifiable concentrate |
US20030180289A1 (en) * | 1999-09-23 | 2003-09-25 | Foster Keith Alan | Inhibition of secretion from non-neuronal cells |
WO2001025738A1 (en) | 1999-10-05 | 2001-04-12 | Cilliers Bartolomomeus Johanne | Measuring twist due to torque in a rotating shaft |
US6113915A (en) | 1999-10-12 | 2000-09-05 | Allergan Sales, Inc. | Methods for treating pain |
CA2385163A1 (en) | 1999-10-14 | 2001-04-19 | Rose Manufacturing Company | Lanyard with integral fall arrest energy absorber |
US6306423B1 (en) * | 2000-06-02 | 2001-10-23 | Allergan Sales, Inc. | Neurotoxin implant |
US20030219462A1 (en) * | 2000-07-21 | 2003-11-27 | Allergan Sales, Inc | Clostridial neurotoxin compositions and modified clostridial neurotoxins |
DE10043982A1 (de) * | 2000-09-05 | 2002-03-14 | Armin Maurer | Verfahren zur Verbesserung des Haarwuchses menschlichen Kopfhaares |
US20020086036A1 (en) * | 2000-12-05 | 2002-07-04 | Allergan Sales, Inc. | Methods for treating hyperhidrosis |
JP4138651B2 (ja) * | 2001-07-27 | 2008-08-27 | ボード オブ スーパーバイザーズ オブ ルイジアナ ステイト ユニバーシティ アンド アグリカルチュラル アンド メカニカル カレッジ | にきび治療または防止のためのボツリヌス毒素 |
US7115399B2 (en) * | 2001-07-31 | 2006-10-03 | Allergan, Inc. | Pinna reflex assay |
US20050106183A1 (en) * | 2002-01-31 | 2005-05-19 | Lamb Gregory B. | Method of treating pain |
US7022329B2 (en) * | 2002-02-25 | 2006-04-04 | Allergan, Inc. | Method for treating neurogenic inflammation pain with botulinum toxin and substance P components |
US7140371B2 (en) * | 2002-03-14 | 2006-11-28 | Allergan, Inc. | Surface topography method for determining effects of a botulinum toxin upon a muscle and for comparing botulinum toxins |
US7300412B2 (en) * | 2002-05-10 | 2007-11-27 | Hospital For Joint Diseases | Methods for therapeutic treatment of carpal tunnel syndrome |
US7691394B2 (en) * | 2002-05-28 | 2010-04-06 | Botulinum Toxin Research Associates, Inc. | High-potency botulinum toxin formulations |
WO2003101483A1 (en) * | 2002-05-31 | 2003-12-11 | Solux Corporation | Pharmaceutical preparation of botulinum neurotoxin, methods of synthesis and methods of clinical use |
US6776991B2 (en) * | 2002-06-26 | 2004-08-17 | Allergan, Inc. | Methods for treating priapism |
US20040009180A1 (en) * | 2002-07-11 | 2004-01-15 | Allergan, Inc. | Transdermal botulinum toxin compositions |
JPWO2004016783A1 (ja) | 2002-08-06 | 2006-01-19 | 株式会社ジェノックス創薬研究所 | アトピー性皮膚炎の検査方法 |
EP2272340B1 (en) * | 2002-08-19 | 2018-03-14 | Ira Sanders | Botulinum toxin |
US7824693B2 (en) * | 2002-08-19 | 2010-11-02 | Ira Sanders | Treatment of fine wrinkles with clostridia neurotoxins |
US20040115222A1 (en) * | 2002-09-06 | 2004-06-17 | Michael Kane | Method for reduction of wrinkles |
DE50313304D1 (de) * | 2002-09-10 | 2011-01-20 | Siemens Ag | Verfahren zur Kontrolle von Übertragungsressourcen eines paketorientierten Kommunikationsnetzes bei Topologieänderungen |
US7422753B2 (en) * | 2003-04-25 | 2008-09-09 | Allergan, Inc. | Methods for treating trichotillomania |
US6838434B2 (en) | 2003-05-02 | 2005-01-04 | Allergan, Inc. | Methods for treating sinus headache |
US20050042775A1 (en) * | 2003-08-21 | 2005-02-24 | Nicholas Pomato | Botulinum antitoxin compositions and methods |
US7148041B2 (en) | 2003-09-25 | 2006-12-12 | Allergan, Inc. | Animal product free media and processes for obtaining a botulinum toxin |
US20050144029A1 (en) * | 2003-12-31 | 2005-06-30 | Rakowski Richard R. | Systems and methods for aesthetic improvement |
ES2338017T3 (es) * | 2004-01-05 | 2010-05-03 | Botulinum Toxin Research Associates, Inc. | Metodos de utilizacion de la toxina botulinica para el tratamiento de la deformacion de los labios hipervolemica (ectropion de los labios). |
US9078892B2 (en) * | 2004-02-26 | 2015-07-14 | Allergan, Inc. | Methods for treating pain and for treating a medication overuse disorder |
US7691381B2 (en) * | 2004-04-15 | 2010-04-06 | Allergan, Inc. | Stabilized biodegradable neurotoxin implants |
KR100852824B1 (ko) * | 2004-07-26 | 2008-08-18 | 메르츠 파마 게엠베하 운트 코. 카가아 | 보툴리눔 신경독소를 포함하는 치료 조성물 |
US20060057165A1 (en) * | 2004-09-10 | 2006-03-16 | Dimitrios Dimitrakoudis | Clostridium botulinum toxin formulation and method for reducing weight |
KR20070057862A (ko) * | 2004-09-27 | 2007-06-07 | 메르츠 파마 게엠베하 운트 코. 카가아 | 조직 치유에 사용하기 위한 클로스트리디움 신경독 |
US20060073208A1 (en) * | 2004-10-01 | 2006-04-06 | Allergan, Inc. | Cosmetic neurotoxin compositions and methods |
PL1830872T3 (pl) * | 2004-12-01 | 2011-09-30 | Sec Dep For Health | Białka fuzyjne |
GB0426394D0 (en) * | 2004-12-01 | 2005-01-05 | Health Prot Agency | Fusion proteins |
FR2879462B1 (fr) * | 2004-12-21 | 2008-12-26 | Sod Conseils Rech Applic | Utilisation de toxine botulique pour une insensibilisation locale prolongee |
US20080220021A1 (en) * | 2005-02-14 | 2008-09-11 | Pankaj Modi | Topical Botulinum Toxin Compositions for the Treatment of Hyperhidrosis |
CA2597244A1 (en) * | 2005-03-03 | 2006-09-14 | Universite Catholique De Louvain | Methods and compositions for the treatment of cancer |
US20060269574A1 (en) * | 2005-05-31 | 2006-11-30 | De Beer Johann F | Method of repairing tendons by surgery |
US8105611B2 (en) * | 2005-06-17 | 2012-01-31 | Allergan, Inc. | Treatment of autoimmune disorder with a neurotoxin |
US20070128226A1 (en) * | 2005-12-01 | 2007-06-07 | Philip Radovic | Methods of treating pain associated with abnormalities of the first metatarsophalangeal joint of the foot |
US7824694B2 (en) * | 2006-01-12 | 2010-11-02 | Allergan, Inc. | Methods for enhancing therapeutic effects of a neurotoxin |
US8658391B2 (en) * | 2006-04-27 | 2014-02-25 | Anterios, Inc. | Assessment of the effects of topical administration of chemodenervating pharmaceuticals |
AR061669A1 (es) * | 2006-06-29 | 2008-09-10 | Merz Pharma Gmbh & Co Kgaa | Aplicacion de alta frecuencia de terapia con toxina botulinica |
EP1985276A1 (en) * | 2007-04-26 | 2008-10-29 | Merz Pharma GmbH & Co. KGaA | Treatment of movement disorders by a combined use of a chemodenervating agent and automated movement therapy |
WO2008145359A1 (en) * | 2007-06-01 | 2008-12-04 | Merz Pharma Gmbh & Co. Kgaa | Process for providing a temperature - stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin |
US8586081B2 (en) * | 2007-09-20 | 2013-11-19 | University Of Massachusetts | Detoxified recombinant botulinum neurotoxin |
US9038912B2 (en) * | 2007-12-18 | 2015-05-26 | Microsoft Technology Licensing, Llc | Trade card services |
AU2009286973B2 (en) * | 2008-08-29 | 2014-06-12 | Merz Pharma Gmbh & Co. Kgaa | Clostridial neurotoxins with altered persistency |
JP5795539B2 (ja) * | 2009-02-19 | 2015-10-14 | メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー | 高純度の神経毒素を製造するための手段および方法 |
ES2693705T3 (es) * | 2009-07-02 | 2018-12-13 | Merz Pharma Gmbh & Co. Kgaa | Neurotoxinas que muestran actividad biológica reducida |
PL2526200T3 (pl) * | 2010-01-22 | 2016-10-31 | Test in vitro do oznaczania ilościowego aktywności neurotoksyny klostridialnej | |
WO2013068472A1 (en) * | 2011-11-09 | 2013-05-16 | Merz Pharma Gmbh & Co. Kgaa | Modified neurotoxins with poly-glycine and uses thereof |
KR102272580B1 (ko) * | 2013-07-30 | 2021-07-05 | 메르츠 파마 게엠베하 운트 코. 카가아 | 보툴리눔 독소의 고순도 신경독성 성분의 제조 방법 및 이의 용도 |
-
2007
- 2007-06-27 AR ARP070102861A patent/AR061669A1/es unknown
- 2007-06-28 KR KR1020147032748A patent/KR20140142377A/ko active Application Filing
- 2007-06-28 CA CA2654214A patent/CA2654214C/en active Active
- 2007-06-28 BR BRPI0713061-9A patent/BRPI0713061A2/pt not_active IP Right Cessation
- 2007-06-28 RU RU2009102848/15A patent/RU2453333C2/ru active
- 2007-06-28 EP EP12001562A patent/EP2484373A1/en not_active Withdrawn
- 2007-06-28 CL CL200701911A patent/CL2007001911A1/es unknown
- 2007-06-28 KR KR1020157031398A patent/KR20150126979A/ko not_active Application Discontinuation
- 2007-06-28 TW TW096123534A patent/TWI519310B/zh active
- 2007-06-28 UY UY30450A patent/UY30450A1/es not_active Application Discontinuation
- 2007-06-28 WO PCT/EP2007/005754 patent/WO2008000490A1/en active Application Filing
- 2007-06-28 EP EP07764931A patent/EP2032157A1/en not_active Ceased
- 2007-06-28 CN CNA2007800206820A patent/CN101460190A/zh active Pending
- 2007-06-28 JP JP2009517002A patent/JP5897784B2/ja active Active
- 2007-06-28 MX MX2009000253A patent/MX2009000253A/es active IP Right Grant
- 2007-06-28 AU AU2007264008A patent/AU2007264008B2/en active Active
- 2007-06-28 KR KR1020097001114A patent/KR20090027732A/ko active Application Filing
- 2007-06-29 US US11/824,393 patent/US8557255B2/en active Active
-
2008
- 2008-10-06 ZA ZA200808491A patent/ZA200808491B/xx unknown
- 2008-11-10 IL IL195201A patent/IL195201A/en active IP Right Grant
-
2013
- 2013-09-13 US US14/026,289 patent/US9095523B2/en active Active
- 2013-09-27 JP JP2013201656A patent/JP2014015476A/ja not_active Withdrawn
-
2015
- 2015-06-25 US US14/749,834 patent/US9572871B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
TW200819140A (en) | 2008-05-01 |
EP2484373A1 (en) | 2012-08-08 |
CA2654214A1 (en) | 2008-01-03 |
BRPI0713061A2 (pt) | 2012-04-10 |
IL195201A0 (en) | 2009-08-03 |
AU2007264008A1 (en) | 2008-01-03 |
JP2009541396A (ja) | 2009-11-26 |
KR20090027732A (ko) | 2009-03-17 |
JP5897784B2 (ja) | 2016-03-30 |
EP2032157A1 (en) | 2009-03-11 |
CL2007001911A1 (es) | 2008-03-14 |
CA2654214C (en) | 2023-07-04 |
MX2009000253A (es) | 2009-01-22 |
IL195201A (en) | 2015-11-30 |
KR20150126979A (ko) | 2015-11-13 |
AR061669A1 (es) | 2008-09-10 |
TWI519310B (zh) | 2016-02-01 |
UY30450A1 (es) | 2009-04-30 |
AU2007264008B2 (en) | 2012-06-28 |
US20140010803A1 (en) | 2014-01-09 |
US9095523B2 (en) | 2015-08-04 |
US9572871B2 (en) | 2017-02-21 |
KR20140142377A (ko) | 2014-12-11 |
RU2009102848A (ru) | 2010-08-10 |
JP2014015476A (ja) | 2014-01-30 |
RU2453333C2 (ru) | 2012-06-20 |
CN101460190A (zh) | 2009-06-17 |
US20150290303A1 (en) | 2015-10-15 |
WO2008000490A1 (en) | 2008-01-03 |
US20080003241A1 (en) | 2008-01-03 |
US8557255B2 (en) | 2013-10-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA200808491B (en) | High frequency application of neurotoxic component of botulinum toxin | |
HK1218706A1 (zh) | 製備吸收複合材料的方法和利用吸收複合材料的吸收製品 | |
HK1136219A1 (en) | Microorganisms or fractions thereof capable of activating cellular immunity against carbohydrates | |
GB2455454B (en) | Methods of processing encoder signals | |
HK1144198A1 (en) | Macrocyclic serine protease inhibitors | |
IL192555A0 (en) | Method of treating multiple sclerosis | |
EP1896805A4 (en) | USES OF LASER-TREATED SUBSTRATE FOR MOLECULAR DIAGNOSIS | |
IL195515A0 (en) | Macrocyclic oximyl hepatitis c protease inhibitors | |
HK1111853A1 (zh) | 高頻補償 | |
EP2124329A4 (en) | HIGH FREQUENCY AMPLIFICATION | |
EP2041064A4 (en) | ALKYL LACTYL LACTATES AND METHODS FOR PREPARING THEM | |
GB0621607D0 (en) | Inhibitors of c-Met | |
EP2052847A4 (en) | SERVOPRESS AND OPERATING METHOD THEREFOR | |
ZA201004393B (en) | Use of neurotoxic component of a clostridium botulinum toxin complax to reduce or prevent side effects | |
ZA200907875B (en) | Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin | |
HK1184055A1 (en) | Use of botulinum toxin for treating hyperhydrosis | |
GB0817618D0 (en) | Decoding frequency channelised signals | |
GB2455474B (en) | Industrial absorbents and methods of manufacturing the same | |
EP2032373A4 (en) | OUTER HOUSING FOR A REFRIGERATOR AND MANUFACTURING METHOD THEREFOR | |
EP1983192A4 (en) | METHOD FOR MANUFACTURING THE SLIDING COMPONENT COMPRESSOR COMPRESSOR | |
HK1147840A1 (zh) | 包覆成型的鍵區及製造方法 | |
EP2069521A4 (en) | BIOMARKERS OF SCLEROSIS IN PLATE | |
EP1854897A4 (en) | METHOD FOR MANUFACTURING A SLIPPER MEMBER | |
GB0612921D0 (en) | CMOS circuits suitable for low noise RF applications | |
EP2063441A4 (en) | CAPACITOR AND HIGH FREQUENCY COMPONENT |