ZA200807074B - 4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as PLK1 inhibitors - Google Patents

4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as PLK1 inhibitors

Info

Publication number
ZA200807074B
ZA200807074B ZA200807074A ZA200807074A ZA200807074B ZA 200807074 B ZA200807074 B ZA 200807074B ZA 200807074 A ZA200807074 A ZA 200807074A ZA 200807074 A ZA200807074 A ZA 200807074A ZA 200807074 B ZA200807074 B ZA 200807074B
Authority
ZA
South Africa
Prior art keywords
thiazole
phenyl
acid amides
carboxylic acid
carboxylic acids
Prior art date
Application number
ZA200807074A
Other languages
English (en)
Inventor
Boylan John Frederick
Cai Jianping
Fotouhi Nader
Gillespie Paul
Goodnow Robert Alan Jr
Le Kang
Michoud Christophe
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA200807074B publication Critical patent/ZA200807074B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
ZA200807074A 2006-02-27 2008-08-15 4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as PLK1 inhibitors ZA200807074B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77696406P 2006-02-27 2006-02-27

Publications (1)

Publication Number Publication Date
ZA200807074B true ZA200807074B (en) 2009-10-28

Family

ID=38051896

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200807074A ZA200807074B (en) 2006-02-27 2008-08-15 4-phenyl-thiazole-5-carboxylic acids and 4-phenyl-thiazole-5-carboxylic acid amides as PLK1 inhibitors

Country Status (19)

Country Link
US (1) US7504513B2 (zh)
EP (1) EP1991543A1 (zh)
JP (1) JP2009528284A (zh)
KR (1) KR101060539B1 (zh)
CN (1) CN101415704A (zh)
AR (1) AR059621A1 (zh)
AU (1) AU2007217575A1 (zh)
BR (1) BRPI0710473A2 (zh)
CA (1) CA2642921A1 (zh)
CR (1) CR10206A (zh)
EC (1) ECSP088700A (zh)
IL (1) IL193481A0 (zh)
MA (1) MA30260B1 (zh)
MX (1) MX2008010884A (zh)
NO (1) NO20083708L (zh)
RU (1) RU2008138163A (zh)
TW (1) TW200745097A (zh)
WO (1) WO2007096315A1 (zh)
ZA (1) ZA200807074B (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5246158B2 (ja) * 2007-06-08 2013-07-24 日本電気株式会社 半導体集積回路及びフィルタ制御方法
WO2009094224A1 (en) 2008-01-25 2009-07-30 Millennium Pharmaceuticals, Inc. Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors
CA2721722C (en) * 2008-04-17 2015-12-08 The Johns Hopkins University On01910.na enhances chemotherapeutic agent activity in drug-resistant tumors
CN102150210B (zh) * 2008-09-10 2013-04-10 数据激光有限公司 数据存储介质
WO2010077295A1 (en) * 2008-12-09 2010-07-08 King Faisal Specialist Hospital & Research Centre Substituted tricyclic heterocycles and uses to treat tumors and proliferative disorders
SG172229A1 (en) * 2008-12-18 2011-07-28 Hoffmann La Roche Thiazolyl-benzimidazoles
US8796314B2 (en) 2009-01-30 2014-08-05 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US9090601B2 (en) * 2009-01-30 2015-07-28 Millennium Pharmaceuticals, Inc. Thiazole derivatives
US9139589B2 (en) 2009-01-30 2015-09-22 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
EP2603216A4 (en) 2010-08-11 2013-12-18 Millennium Pharm Inc HETEROARYLE AND USES THEREOF
CN103153300A (zh) 2010-08-11 2013-06-12 米伦纽姆医药公司 杂芳基化合物和其用途
US9062038B2 (en) 2010-08-11 2015-06-23 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
WO2012051410A2 (en) 2010-10-13 2012-04-19 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof

Family Cites Families (23)

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US4322429A (en) * 1980-09-16 1982-03-30 Eli Lilly And Company Isoxazolylbenzamides as insecticides
US4818270A (en) * 1986-08-28 1989-04-04 Monsanto Company 2-(Heteroamino)-4,5-substituted-oxazole/thiazole compounds as herbicide antidotes, compositions and use
US6194447B1 (en) * 1998-07-02 2001-02-27 Neurosearch A/S Bis (benzimidazole) derivatives serving as potassium blocking agents
BR0113176A (pt) 2000-08-10 2003-06-17 Pharmacia Italia Spa Compostos biciclo-pirazol, composições farmacêuticas compreendendo os compostos, uso dos compostos na fabricação de medicamentos, processos para a preparação dos compostos, coleção quìmica combinatória e métodos para o tratamento de mamìferos incluindo humanos utilizando os compostos
GB0102687D0 (en) 2001-02-02 2001-03-21 Pharmacia & Upjohn Spa Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them
WO2003070283A2 (en) 2002-02-22 2003-08-28 Klaus Strebhardt Agent for inhibiting development or progress of proliferative diseases and especially cancer diseases and pharmaceutical composition containing said agent
JP2003321460A (ja) * 2002-02-28 2003-11-11 Takeda Chem Ind Ltd アゾール化合物
EP1486490A1 (en) * 2002-02-28 2004-12-15 Takeda Chemical Industries, Ltd. Azole compounds
AU2003213660C1 (en) 2002-02-28 2010-10-28 Onconova Therapeutics, Inc. Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders
PL372890A1 (en) 2002-05-03 2005-08-08 Schering Aktiengesellschaft Thiazolidinones and the use thereof as polo-like kinase inhibitors
US6906186B1 (en) 2002-07-30 2005-06-14 Isis Pharmaceuticals, Inc. Antisense modulation of polo-like kinase expression
MXPA05001544A (es) 2002-08-08 2005-04-19 Smithkline Beecham Corp Compuestos de tiofeno.
EP1576128A4 (en) 2002-11-14 2008-02-13 Massachusetts Inst Technology PRODUCTS AND METHODS FOR MODULATING INTERACTIONS BETWEEN PEPTIDE PEPTIDE BINDING DOMAINS
AU2003284399A1 (en) 2002-11-14 2004-06-03 Kyowa Hakko Kogyo Co., Ltd. Plk inhibitors
WO2004054186A1 (ja) 2002-12-12 2004-06-24 Fujitsu Limited データ中継装置、連想メモリデバイス、および連想メモリデバイス利用情報検索方法
GB0302220D0 (en) 2003-01-30 2003-03-05 Cyclacel Ltd Use
ES2325440T3 (es) 2003-02-20 2009-09-04 Smithkline Beecham Corporation Compuestos de pirimidina.
JP2006522127A (ja) 2003-04-01 2006-09-28 スミスクライン ビーチャム コーポレーション イミダゾトリアジン化合物
BRPI0411794A (pt) 2003-06-24 2006-08-08 Pfizer Prod Inc processos para a preparação de derivados de 1-[(benzoimidazol-1-il)quinolin-8-il]piperidin-4-ilamina
WO2005019193A2 (en) 2003-08-20 2005-03-03 Smithkline Beecham Corporation Phenylurea derivatives useful in the treatment of conditions mediated by polo-like kinases (plk)
JP5164380B2 (ja) 2003-10-21 2013-03-21 サイクラセル リミテッド ピリミジン−４−イル−３，４−チオン化合物及び治療におけるその使用
DE10351744A1 (de) 2003-10-31 2005-06-16 Schering Ag Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel
WO2005075470A1 (en) 2004-01-28 2005-08-18 Smithkline Beecham Corporation Thiazole compounds

Also Published As

Publication number Publication date
NO20083708L (no) 2008-09-23
ECSP088700A (es) 2008-09-29
WO2007096315A1 (en) 2007-08-30
TW200745097A (en) 2007-12-16
US7504513B2 (en) 2009-03-17
IL193481A0 (en) 2009-05-04
JP2009528284A (ja) 2009-08-06
CA2642921A1 (en) 2007-08-30
AU2007217575A1 (en) 2007-08-30
US20070203210A1 (en) 2007-08-30
AR059621A1 (es) 2008-04-16
KR101060539B1 (ko) 2011-08-30
BRPI0710473A2 (pt) 2011-08-16
RU2008138163A (ru) 2010-04-10
CN101415704A (zh) 2009-04-22
KR20080090550A (ko) 2008-10-08
CR10206A (es) 2008-09-22
MX2008010884A (es) 2008-09-03
EP1991543A1 (en) 2008-11-19
MA30260B1 (fr) 2009-03-02

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