PL3699162T3 - Heterodimery kwasu glutaminowego - Google Patents
Heterodimery kwasu glutaminowegoInfo
- Publication number
- PL3699162T3 PL3699162T3 PL19214298.2T PL19214298T PL3699162T3 PL 3699162 T3 PL3699162 T3 PL 3699162T3 PL 19214298 T PL19214298 T PL 19214298T PL 3699162 T3 PL3699162 T3 PL 3699162T3
- Authority
- PL
- Poland
- Prior art keywords
- heterodimers
- glutamic acid
- glutamic
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
- C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic System
- C07F1/005—Compounds containing elements of Groups 1 or 11 of the Periodic System without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
- C07F13/005—Compounds without a metal-carbon linkage
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85749006P | 2006-11-08 | 2006-11-08 | |
US87867807P | 2007-01-05 | 2007-01-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL3699162T3 true PL3699162T3 (pl) | 2022-10-31 |
Family
ID=39365345
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL19214298.2T PL3699162T3 (pl) | 2006-11-08 | 2007-11-07 | Heterodimery kwasu glutaminowego |
PL15168948T PL2942065T3 (pl) | 2006-11-08 | 2007-11-07 | Heterodimery kwasu glutamowego |
PL07844938T PL2097111T3 (pl) | 2006-11-08 | 2007-11-07 | Heterodimery kwasu glutaminowego |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL15168948T PL2942065T3 (pl) | 2006-11-08 | 2007-11-07 | Heterodimery kwasu glutamowego |
PL07844938T PL2097111T3 (pl) | 2006-11-08 | 2007-11-07 | Heterodimery kwasu glutaminowego |
Country Status (16)
Country | Link |
---|---|
US (11) | US20080193381A1 (pl) |
EP (5) | EP2097111B1 (pl) |
JP (2) | JP5606737B2 (pl) |
CN (2) | CN103922998A (pl) |
BR (1) | BRPI0718700B8 (pl) |
CA (1) | CA2669127C (pl) |
CY (1) | CY1116610T1 (pl) |
DK (1) | DK2097111T3 (pl) |
ES (4) | ES2847275T3 (pl) |
HK (2) | HK1200164A1 (pl) |
HU (3) | HUE059645T2 (pl) |
PL (3) | PL3699162T3 (pl) |
PT (2) | PT3699162T (pl) |
SI (1) | SI2097111T1 (pl) |
TW (1) | TWI492761B (pl) |
WO (1) | WO2008058192A2 (pl) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6528499B1 (en) | 2000-04-27 | 2003-03-04 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALADase |
WO2007001448A2 (en) | 2004-11-04 | 2007-01-04 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
EP1745802A1 (en) * | 2005-07-20 | 2007-01-24 | Kreatech Biotechnology B.V. | Method of conjugating therapeutic compounds to cell targeting moieties via metal complexes |
WO2007070682A2 (en) | 2005-12-15 | 2007-06-21 | Massachusetts Institute Of Technology | System for screening particles |
CA2648099C (en) | 2006-03-31 | 2012-05-29 | The Brigham And Women's Hospital, Inc | System for targeted delivery of therapeutic agents |
WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
EP2097111B1 (en) | 2006-11-08 | 2015-07-15 | Molecular Insight Pharmaceuticals, Inc. | Heterodimers of glutamic acid |
EP2134830A2 (en) | 2007-02-09 | 2009-12-23 | Massachusetts Institute of Technology | Oscillating cell culture bioreactor |
WO2008124639A2 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Poly (amino acid) targeting moieties |
EP2170075B1 (en) * | 2007-06-26 | 2014-12-03 | The Johns Hopkins University | Labeled inhibitors of prostate specific membrane antigen (psma), biological evaluation, and use as imaging agents |
HUE047200T2 (hu) | 2007-08-17 | 2020-04-28 | Purdue Research Foundation | PSMA kötõ ligandum-linker konjugátumok és azok alkalmazási módszerei |
EP2436376B1 (en) * | 2007-09-28 | 2014-07-09 | BIND Therapeutics, Inc. | Cancer cell targeting using nanoparticles |
ES2627292T3 (es) | 2007-10-12 | 2017-07-27 | Massachusetts Institute Of Technology | Nanotecnología de vacunas |
US8562945B2 (en) | 2008-01-09 | 2013-10-22 | Molecular Insight Pharmaceuticals, Inc. | Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof |
CA2711678A1 (en) | 2008-01-09 | 2009-07-16 | Molecular Insight Pharmaceuticals, Inc. | Inhibitors of carbonic anhydrase ix |
JP2011525180A (ja) * | 2008-06-16 | 2011-09-15 | バインド バイオサイエンシズ インコーポレイテッド | 治療的標的化ナノ粒子の製作に用いるためのジブロックコポリマーで官能化された標的薬の製造方法 |
EP2309990B2 (en) | 2008-06-16 | 2017-03-15 | Pfizer Inc. | Drug loaded polymeric nanoparticles and methods of making and using same |
US8613951B2 (en) | 2008-06-16 | 2013-12-24 | Bind Therapeutics, Inc. | Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same |
ES2721850T3 (es) | 2008-06-16 | 2019-08-05 | Pfizer | Nanopartículas poliméricas terapéuticas que comprenden alcaloides vinca y procedimientos de fabricación y uso de las mismas |
PL3222615T3 (pl) | 2008-08-01 | 2022-09-26 | The Johns Hopkins University | Środki wiążące psma i ich zastosowania |
US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
US8211402B2 (en) | 2008-12-05 | 2012-07-03 | Molecular Insight Pharmaceuticals, Inc. | CA-IX specific radiopharmaceuticals for the treatment and imaging of cancer |
PL2389361T3 (pl) * | 2008-12-05 | 2017-02-28 | Molecular Insight Pharmaceuticals, Inc. | Kompleksy bis(heteroarylowe) technetu i renu oraz sposoby ich zastosowania do hamowania PSMA |
US8563041B2 (en) | 2008-12-12 | 2013-10-22 | Bind Therapeutics, Inc. | Therapeutic particles suitable for parenteral administration and methods of making and using same |
JP2012512175A (ja) * | 2008-12-15 | 2012-05-31 | バインド バイオサイエンシズ インコーポレイテッド | 治療薬を徐放するための長時間循環性ナノ粒子 |
CN102714296A (zh) | 2009-05-19 | 2012-10-03 | Aic布莱博公司 | 复合集电器及形成其的方法 |
WO2010147965A2 (en) | 2009-06-15 | 2010-12-23 | Molecular Insight Pharmaceuticals, Inc. | Process for production of heterodimers of glutamic acid |
CN102596403A (zh) * | 2009-10-30 | 2012-07-18 | 住友大阪水泥股份有限公司 | 内燃机的废气净化装置 |
US8357401B2 (en) | 2009-12-11 | 2013-01-22 | Bind Biosciences, Inc. | Stable formulations for lyophilizing therapeutic particles |
ES2780156T3 (es) | 2009-12-15 | 2020-08-24 | Pfizer | Composiciones terapéuticas de nanopartículas poliméricas con alta temperatura de transición vítrea o copolímeros de alto peso molecular |
EP2338892A1 (en) * | 2009-12-18 | 2011-06-29 | Bayer Schering Pharma Aktiengesellschaft | Prostate specific membrane antigen inhibitors |
US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
JP2011206049A (ja) | 2010-03-08 | 2011-10-20 | Sumio Sugano | 壊死マーカー及びその用途 |
US10363309B2 (en) | 2011-02-04 | 2019-07-30 | Case Western Reserve University | Targeted nanoparticle conjugates |
AU2012294639B2 (en) * | 2011-08-05 | 2017-10-26 | Molecular Insight Pharmaceuticals, Inc. | Radiolabeled prostate specific membrane antigen inhibitors |
CA2860504A1 (en) | 2012-01-06 | 2013-07-11 | Molecular Insight Pharmaceuticals | Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase ix |
BR112015005940A2 (pt) | 2012-09-17 | 2017-07-04 | Bind Therapeutics Inc | processo para a preparação de nanopartículas terapêuticas |
JP6892218B2 (ja) | 2012-11-15 | 2021-06-23 | エンドサイト・インコーポレイテッドEndocyte, Inc. | 薬物送達結合体およびpsma発現細胞によって引き起こされる疾患の治療方法 |
CN105025933B (zh) | 2013-01-14 | 2019-03-26 | 分子制药洞察公司 | 三嗪类放射性药物和放射性显影剂 |
US10207005B2 (en) | 2013-02-15 | 2019-02-19 | Case Western Reserve University | Photodynamic therapy composition |
US9889199B2 (en) | 2013-02-15 | 2018-02-13 | Case Western Reserve University | PSMA ligands and uses thereof |
US10434194B2 (en) | 2013-06-20 | 2019-10-08 | Case Western Reserve University | PSMA targeted nanobubbles for diagnostic and therapeutic applications |
US10232058B2 (en) | 2013-10-14 | 2019-03-19 | The Johns Hopkins University | Prostate-specific membrane antigen-targeted photosensitizers for photodynamic therapy |
PE20160678A1 (es) | 2013-10-18 | 2016-08-06 | Deutsches Krebsforsch | Inhibidores marcados de antigeno prostatico especifico de membrana (psma), su uso como agentes formadores de imagenes y agentes farmaceuticos para el tratamiento de cancer de prostata |
JP6908964B2 (ja) * | 2013-10-18 | 2021-07-28 | ピーエスエムエー ディベロップメント カンパニー,エルエルシー | Psmaリガンドコンジュゲートによる併用療法 |
US20150110814A1 (en) * | 2013-10-18 | 2015-04-23 | Psma Development Company, Llc | Combination therapies with psma ligand conjugates |
WO2015073896A2 (en) | 2013-11-15 | 2015-05-21 | Psma Development Company, Llc | Biomarkers for psma targeted therapy for prostate cancer |
MX2016012009A (es) | 2014-03-14 | 2016-12-05 | Pfizer | Nanoparticulas terapeuticas que comprenden un agente terapeutico, y metodos para su elaboracion y uso. |
WO2016030329A1 (en) * | 2014-08-24 | 2016-03-03 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for the production of 18f-labeled active esters and their application exemplified by the preparation of a psma-specific pet-tracer |
JP2017530109A (ja) * | 2014-09-08 | 2017-10-12 | モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド | 前立腺癌についてのpsmaを標的とした放射性核種治療中の臓器の保護 |
WO2016065145A2 (en) | 2014-10-22 | 2016-04-28 | The Johns Hopkins University | Psma targeted reversed carbamates and methods of use thereof |
US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
WO2016112382A2 (en) * | 2015-01-09 | 2016-07-14 | The Johns Hopkins University | Intranasal administration of glutamate carboxypeptidase (gcp-ii) inhibitors |
PE20181350A1 (es) | 2015-09-30 | 2018-08-22 | Deutsches Krebsforsch | Inhibidores marcados con 18f mejorados de antigeno de membrana especifico de prostata (psma) y su uso como agentes de diagnostico por imagenes para el cancer de prostata |
KR101639599B1 (ko) | 2015-11-09 | 2016-07-14 | 서울대학교산학협력단 | 펩타이드 싸이오우레아 유도체, 이를 포함하는 방사성 동위원소 표지 화합물 및 이를 유효 성분으로 함유하는 전립선암 치료 또는 진단용 약학적 조성물 |
EP3400229B1 (en) | 2016-01-10 | 2024-03-06 | Provincial Health Services Authority | 18/19f-labelled compounds which target the prostate specific membrane antigen |
WO2017184231A1 (en) | 2016-04-20 | 2017-10-26 | Dow Corning Corporation | Lithium alkylsiliconate composition, coating, and method of making same |
FI127538B (en) * | 2016-06-22 | 2018-08-31 | Dextech Medical Ab | MODIFIED Dextran Conjugates |
JP7317505B2 (ja) * | 2016-06-23 | 2023-07-31 | コーネル ユニバーシティー | 腫瘍死滅に影響する二重標的構築物 |
KR20190038807A (ko) * | 2016-06-28 | 2019-04-09 | 코넬 유니버시티 | 18f-표지된 트라이아졸 함유 psma 억제제 |
CA3058663A1 (en) | 2017-04-05 | 2018-10-11 | Cornell University | Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies |
WO2018224660A1 (en) * | 2017-06-09 | 2018-12-13 | Armin Ehninger | Targeting modules for universal chimeric antigen receptor expressing immune cells and use in the treatment of cancer infections and autoimmune disorders |
US11813340B2 (en) | 2018-02-06 | 2023-11-14 | The Johns Hopkins University | PSMA targeted radiohalogenated urea-polyaminocarboxylates for cancer radiotherapy |
WO2019183633A1 (en) | 2018-03-23 | 2019-09-26 | Case Western Reserve Univeristy | Psma targeted conjugate compounds and uses thereof |
JP7429688B2 (ja) * | 2018-09-21 | 2024-02-08 | エンドサイト・インコーポレイテッド | シールド剤およびそれらの使用 |
EP3863627A1 (en) | 2018-10-11 | 2021-08-18 | Progenics Pharmaceuticals, Inc. | Combination therapy for treating metastatic prostate cancer |
RU2697519C1 (ru) * | 2018-10-15 | 2019-08-15 | Общество с ограниченной ответственностью "Изварино Фарма" | Средство пептидной природы, включающее псма-связывающий лиганд на основе производного мочевины, способ его получения и применение для получения конъюгата с лекарственным и диагностическим агентом |
WO2020139012A1 (ko) * | 2018-12-27 | 2020-07-02 | (주)퓨쳐켐 | 카르복시산이 도입된 psma-표적 화합물 및 그의 용도 |
EP3986872A4 (en) | 2019-06-21 | 2024-02-21 | Provincial Health Services Authority | RADIOM LABELED COMPOUNDS DIRECTED AGAINST THE PROSTATE SPECIFIC MEMBRANE ANTIGEN |
KR20220103774A (ko) * | 2019-11-21 | 2022-07-22 | 페로노바 피티와이 리미티드 | 자성 추적자 조성물 |
WO2021202376A1 (en) | 2020-03-30 | 2021-10-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method for blocking uptake of prostate-specific membrane antigen (psma)-targeted radionuclides by exocrine organs |
CN111548305B (zh) * | 2020-05-12 | 2021-08-31 | 北京师范大学 | 一种可用于靶向psma的喹啉类化合物及其制备方法 |
CN112209970B (zh) * | 2020-10-21 | 2021-10-29 | 北京师范大学 | 一种锝-99m标记含异腈的谷氨酸-脲衍生物的制备方法和应用 |
EP4244216A1 (en) | 2020-11-12 | 2023-09-20 | ABX Advanced Biochemical Compounds GmbH | Ligands of prostate specific membrane antigen (psma) containing heteroaromatic linker building blocks |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3527789A (en) * | 1967-10-06 | 1970-09-08 | Shell Oil Co | Production of poly(lower)alkyl alkenepolycarboxylates |
JP2608550B2 (ja) * | 1986-10-17 | 1997-05-07 | 株式会社 片山化学工業研究所 | 軟水ボイラの防食処理方法 |
US4888136A (en) * | 1988-05-02 | 1989-12-19 | Witco Corporation | New flame retardant compositions of matter and cellulosic products containing same |
TW353663B (en) * | 1991-04-06 | 1999-03-01 | Hoechst Ag | Process for the preparation of phosphorus-containing L-amino acids, their derivatives and intermediates for this process |
IT1270260B (it) * | 1994-06-21 | 1997-04-29 | Zambon Spa | Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi |
US6011021A (en) | 1996-06-17 | 2000-01-04 | Guilford Pharmaceuticals Inc. | Methods of cancer treatment using naaladase inhibitors |
US5795877A (en) * | 1996-12-31 | 1998-08-18 | Guilford Pharmaceuticals Inc. | Inhibitors of NAALADase enzyme activity |
US6071965A (en) * | 1996-06-17 | 2000-06-06 | Guilford Pharmaceuticals Inc. | Phosphinic alkanoic acid derivatives |
US6046180A (en) | 1996-06-17 | 2000-04-04 | Guilford Pharmaceuticals Inc. | NAALADase inhibitors |
US5824662A (en) * | 1996-09-27 | 1998-10-20 | Guilford Pharmaceuticals Inc. | Treatment of global and focal ischemia using naaladase inhibitors |
US5902817A (en) | 1997-04-09 | 1999-05-11 | Guilford Pharmaceuticals Inc. | Certain sulfoxide and sulfone derivatives |
US5672592A (en) * | 1996-06-17 | 1997-09-30 | Guilford Pharmaceuticals Inc. | Certain phosphonomethyl-pentanedioic acid derivatives thereof |
US6025344A (en) | 1996-06-17 | 2000-02-15 | Guilford Pharmaceuticals Inc. | Certain dioic acid derivatives useful as NAALADase inhibitors |
IL128718A0 (en) | 1996-09-27 | 2000-01-31 | Guildford Pharmaceuticals Inc | Naaldase compositions |
US5962521A (en) | 1997-04-04 | 1999-10-05 | Guilford Pharmaceuticals Inc. | Hydroxamic acid derivatives |
ZA983930B (en) | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
JP5095050B2 (ja) * | 1999-04-28 | 2012-12-12 | ジョージタウン ユニバーシティー | 代謝調節型グルタミン酸受容体のリガンド、及び、NAALADaseの阻害剤 |
US6528499B1 (en) * | 2000-04-27 | 2003-03-04 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALADase |
US6228888B1 (en) | 1999-07-01 | 2001-05-08 | Guilford Pharmaceuticals Inc. | Methods for treating anxiety, anxiety disorders and memory impairment using naaladase inhibitors |
EP1472541B1 (en) * | 2002-01-10 | 2009-09-16 | The Johns Hopkins University | Imaging agents and methods of imaging naaladase of psma |
WO2003077727A2 (en) * | 2002-03-11 | 2003-09-25 | Biostream, Inc. | Technetium-dipyridine complexes, and methods of use thereof |
EP2088206B1 (en) * | 2002-11-07 | 2013-07-03 | Newsouth Innovations Pty Limited | Induction of the mitochondrial permeability transition |
US7682601B2 (en) * | 2003-04-15 | 2010-03-23 | Mallinckrodt Inc. | Bifunctional tridentate pyrazolyl containing ligands for re and tc tricarbonyl complexes |
ATE470456T1 (de) * | 2003-04-15 | 2010-06-15 | Mallinckrodt Inc | Bifunktionale tridentate pyrazolyl-enthaltende liganden für re-, tc- und mn- tricarbonyl- komplexe |
US7741510B2 (en) * | 2005-01-13 | 2010-06-22 | E. I. Du Pont De Nemours And Company | Rheology control agents |
US20060155021A1 (en) * | 2005-01-13 | 2006-07-13 | Lenges Christian P | Coating compositions containing rheology control agents |
WO2006093991A1 (en) * | 2005-03-02 | 2006-09-08 | The Cleveland Clinic Foundation | Compounds which bind psma and uses thereof |
EP2097111B1 (en) | 2006-11-08 | 2015-07-15 | Molecular Insight Pharmaceuticals, Inc. | Heterodimers of glutamic acid |
EP2170075B1 (en) * | 2007-06-26 | 2014-12-03 | The Johns Hopkins University | Labeled inhibitors of prostate specific membrane antigen (psma), biological evaluation, and use as imaging agents |
HUE047200T2 (hu) * | 2007-08-17 | 2020-04-28 | Purdue Research Foundation | PSMA kötõ ligandum-linker konjugátumok és azok alkalmazási módszerei |
EP3964498A1 (en) | 2009-03-19 | 2022-03-09 | The Johns Hopkins University | Psma-targeting compounds and uses thereof |
WO2010147965A2 (en) * | 2009-06-15 | 2010-12-23 | Molecular Insight Pharmaceuticals, Inc. | Process for production of heterodimers of glutamic acid |
AU2012294639B2 (en) | 2011-08-05 | 2017-10-26 | Molecular Insight Pharmaceuticals, Inc. | Radiolabeled prostate specific membrane antigen inhibitors |
PE20160678A1 (es) | 2013-10-18 | 2016-08-06 | Deutsches Krebsforsch | Inhibidores marcados de antigeno prostatico especifico de membrana (psma), su uso como agentes formadores de imagenes y agentes farmaceuticos para el tratamiento de cancer de prostata |
JP2017530109A (ja) | 2014-09-08 | 2017-10-12 | モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド | 前立腺癌についてのpsmaを標的とした放射性核種治療中の臓器の保護 |
-
2007
- 2007-11-07 EP EP07844938.6A patent/EP2097111B1/en active Active
- 2007-11-07 WO PCT/US2007/083934 patent/WO2008058192A2/en active Application Filing
- 2007-11-07 EP EP21208033.7A patent/EP4023624A1/en active Pending
- 2007-11-07 PT PT192142982T patent/PT3699162T/pt unknown
- 2007-11-07 ES ES18150494T patent/ES2847275T3/es active Active
- 2007-11-07 CN CN201410158114.9A patent/CN103922998A/zh active Pending
- 2007-11-07 EP EP18150494.5A patent/EP3335736B1/en not_active Revoked
- 2007-11-07 PL PL19214298.2T patent/PL3699162T3/pl unknown
- 2007-11-07 ES ES19214298T patent/ES2926912T3/es active Active
- 2007-11-07 ES ES07844938.6T patent/ES2547481T3/es active Active
- 2007-11-07 BR BRPI0718700A patent/BRPI0718700B8/pt active IP Right Grant
- 2007-11-07 CN CN200780049490.2A patent/CN101778910B/zh active Active
- 2007-11-07 SI SI200731686T patent/SI2097111T1/sl unknown
- 2007-11-07 ES ES15168948.6T patent/ES2684322T3/es active Active
- 2007-11-07 HU HUE19214298A patent/HUE059645T2/hu unknown
- 2007-11-07 HU HUE15168948A patent/HUE039199T2/hu unknown
- 2007-11-07 PL PL15168948T patent/PL2942065T3/pl unknown
- 2007-11-07 EP EP15168948.6A patent/EP2942065B1/en active Active
- 2007-11-07 DK DK07844938.6T patent/DK2097111T3/en active
- 2007-11-07 PL PL07844938T patent/PL2097111T3/pl unknown
- 2007-11-07 TW TW096142019A patent/TWI492761B/zh active
- 2007-11-07 EP EP19214298.2A patent/EP3699162B1/en active Active
- 2007-11-07 JP JP2009536459A patent/JP5606737B2/ja active Active
- 2007-11-07 PT PT78449386T patent/PT2097111E/pt unknown
- 2007-11-07 US US11/936,659 patent/US20080193381A1/en active Granted
- 2007-11-07 HU HUE07844938A patent/HUE026216T2/en unknown
- 2007-11-07 CA CA2669127A patent/CA2669127C/en active Active
-
2011
- 2011-10-12 US US13/271,549 patent/US9309193B2/en active Active
- 2011-11-11 US US13/294,677 patent/US8487129B2/en active Active
-
2014
- 2014-08-27 JP JP2014172732A patent/JP5936659B2/ja active Active
-
2015
- 2015-01-15 HK HK15100503.3A patent/HK1200164A1/xx unknown
- 2015-08-13 CY CY20151100716T patent/CY1116610T1/el unknown
-
2016
- 2016-03-14 US US15/068,841 patent/US10640461B2/en active Active
- 2016-10-28 US US15/337,867 patent/US9878980B2/en active Active
-
2017
- 2017-10-26 US US15/794,539 patent/US10131627B2/en active Active
-
2018
- 2018-10-10 US US16/156,289 patent/US10647666B2/en active Active
- 2018-12-20 HK HK18116333.2A patent/HK1257260A1/zh unknown
-
2020
- 2020-05-08 US US16/870,288 patent/US20210070695A1/en not_active Abandoned
- 2020-11-16 US US17/099,440 patent/US20210070696A1/en not_active Abandoned
-
2021
- 2021-04-23 US US17/238,535 patent/US20210246103A1/en not_active Abandoned
-
2022
- 2022-11-07 US US17/982,182 patent/US20230095637A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1257260A1 (zh) | 谷氨酸的異質二聚體 | |
BRPI0815045A2 (pt) | Composições de ácido hialurônico ajustavelmente reticuladas | |
HK1134029A1 (en) | Amino acid composition | |
PL2164349T3 (pl) | Bezproteinowa mieszanka dla niemowląt | |
HK1221220A1 (zh) | 環戊基丙烯酰胺衍生物 | |
EP2192109A4 (en) | BICYCLIC AMINO ACID DERIVATIVE | |
ZA201103542B (en) | Novel composition based on gamma-hydroxybutric acid | |
ATE509925T1 (de) | Substituierte bicyclocarbonsäureamidverbindungen | |
HK1131130A1 (en) | Co-crystals of pyrrolidinones | |
GB0604899D0 (en) | Derivatives of 18-glycyrrhetinic acid | |
EP2123752A4 (en) | NOVEL NUCLEIC ACID | |
EP2077326A4 (en) | NOVEL NUCLEIC ACID | |
IL187655A0 (en) | Anthranilic acid derivatives | |
BRPI0919200A2 (pt) | derivado de aminoácido | |
BRPI0814800A2 (pt) | Derivados de aminoácidos | |
GB0602780D0 (en) | Amino Acid Derivatives | |
EP2072498A4 (en) | N-PHENYLOXAMIDE ACID DERIVATIVE | |
IL194330A0 (en) | Processes for the synthesis of 3-isobutylglutaric acid | |
ZA200808501B (en) | Acid Dyes | |
IL197506A0 (en) | Novel phenylacetic acid derivative | |
ZA200807674B (en) | Prodrugs of benzoquinolizine-2-carboxylic acid | |
GB0715712D0 (en) | Amino acid derivatives | |
EP2132171A4 (en) | NOVEL CRYSTALLINE FORMS OF PYRROLYLHEPTANOIC ACID DERIVATIVES | |
PL1966120T3 (pl) | Sole kwasu styfninowego | |
EP2013613A4 (en) | ELECTRODES BRIDGE |