ZA200806072B - Hydantoin derivatives for the treatment of inflammatory disorders - Google Patents
Hydantoin derivatives for the treatment of inflammatory disordersInfo
- Publication number
- ZA200806072B ZA200806072B ZA200806072A ZA200806072A ZA200806072B ZA 200806072 B ZA200806072 B ZA 200806072B ZA 200806072 A ZA200806072 A ZA 200806072A ZA 200806072 A ZA200806072 A ZA 200806072A ZA 200806072 B ZA200806072 B ZA 200806072B
- Authority
- ZA
- South Africa
- Prior art keywords
- treatment
- inflammatory disorders
- hydantoin derivatives
- hydantoin
- derivatives
- Prior art date
Links
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- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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US75930006P | 2006-01-17 | 2006-01-17 |
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ZA200806072B true ZA200806072B (en) | 2009-04-29 |
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ZA200806072A ZA200806072B (en) | 2006-01-17 | 2008-07-11 | Hydantoin derivatives for the treatment of inflammatory disorders |
Country Status (17)
Country | Link |
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US (4) | US7524842B2 (fr) |
EP (2) | EP1973901B1 (fr) |
JP (2) | JP2009523797A (fr) |
KR (2) | KR20080085222A (fr) |
CN (2) | CN101405286A (fr) |
AR (2) | AR059036A1 (fr) |
AU (2) | AU2007207707A1 (fr) |
BR (2) | BRPI0706599A2 (fr) |
CA (2) | CA2637196A1 (fr) |
EC (2) | ECSP088625A (fr) |
IL (2) | IL192690A0 (fr) |
NO (2) | NO20083567L (fr) |
PE (2) | PE20071240A1 (fr) |
RU (2) | RU2008133383A (fr) |
TW (2) | TW200738688A (fr) |
WO (2) | WO2007084451A1 (fr) |
ZA (1) | ZA200806072B (fr) |
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ATE478864T1 (de) | 2004-07-16 | 2010-09-15 | Schering Corp | Hydantoinderivate zur behandlung von entzündlichen erkrankungen |
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ATE518853T1 (de) * | 2005-08-12 | 2011-08-15 | Schering Corp | Verbindungen zur behandlung entzündlicher erkrankungen |
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CN101186611B (zh) * | 2006-11-15 | 2011-05-18 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的吡咯啉-2-酮衍生物及其制备和应用 |
CN101186612B (zh) * | 2006-11-15 | 2012-10-03 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的吡咯啉衍生物及其制备和应用 |
EP2346857B1 (fr) * | 2008-09-24 | 2019-11-27 | Merck Sharp & Dohme Corp. | Composés pour le traitement de troubles inflammatoires |
EP2331528B1 (fr) | 2008-09-24 | 2020-05-27 | Merck Sharp & Dohme Corp. | Composés pour traiter des troubles inflammatoires |
US8569336B2 (en) | 2008-11-10 | 2013-10-29 | Ling Tong | Compounds for the treatment of inflammatory disorders |
WO2010054279A1 (fr) * | 2008-11-10 | 2010-05-14 | Schering Corporation | Composés utilisables pour le traitement de troubles inflammatoires |
CA2804918C (fr) | 2010-07-08 | 2018-03-06 | Kaken Pharmaceutical Co., Ltd. | Derive de n-hydroxyformamide et produit pharmaceutique le contenant |
EP2705024B1 (fr) * | 2011-05-03 | 2015-12-16 | Merck Sharp & Dohme Corp. | Dérivés alcyne benzotriazoles |
PL2789607T3 (pl) * | 2011-12-09 | 2018-08-31 | Kaken Pharmaceutical Co., Ltd. | Pochodna pirydonu i lek zawierający tę pochodną |
AR092971A1 (es) * | 2012-10-26 | 2015-05-06 | Lilly Co Eli | Inhibidores de agrecanasa |
RU2668072C2 (ru) | 2013-06-07 | 2018-09-27 | Какен Фармасьютикал Ко., Лтд. | (+)-5-(3,4-дифторфенил)-5-[(3-метил-2-оксопиридин-1(2h)-ил)метил]имидазолидин-2,4-дион, а также лекарственное средство, включающее его в свой состав |
CN104803861B (zh) * | 2014-01-27 | 2017-05-24 | 上海博邦医药科技有限公司 | 一种合成盐酸他喷他多的方法 |
PE20161372A1 (es) | 2014-02-03 | 2017-01-08 | Vitae Pharmaceuticals Inc | Inhibidores de dihidropirrolopiridina de ror-gamma |
UA118989C2 (uk) | 2014-10-14 | 2019-04-10 | Вітае Фармасьютікалс, Інк. | Дигідропіролопіридинові інгібітори ror-гамма |
US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
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TW201636329A (zh) | 2015-02-02 | 2016-10-16 | 佛瑪治療公司 | 作為hdac抑制劑之雙環[4,6,0]異羥肟酸 |
EA201792673A1 (ru) | 2015-02-02 | 2018-04-30 | Форма Терапьютикс, Инк. | 3-арил-4-амидобициклические [4,5,0] гидроксамовые кислоты в качестве ингибиторов hdac |
MX2018000243A (es) * | 2015-07-09 | 2018-03-08 | Mitsubishi Tanabe Pharma Corp | Derivados novedosos de imida y su uso como medicamento. |
CN105153048B (zh) * | 2015-07-31 | 2017-10-24 | 苏州大学 | 一种2,4‑喹唑啉二酮类化合物的制备方法 |
EP3331876B1 (fr) | 2015-08-05 | 2020-10-07 | Vitae Pharmaceuticals, LLC | Modulateurs de ror-gamma |
MA53943A (fr) | 2015-11-20 | 2021-08-25 | Vitae Pharmaceuticals Llc | Modulateurs de ror-gamma |
TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
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EP3472131B1 (fr) | 2016-06-17 | 2020-02-19 | Forma Therapeutics, Inc. | Acides hydroxamiques de 2-spiro-indan-5-yl ou de 2-spiro-indan-6-yl utilisés en tant qu'inhibiteurs de hdac |
JP2019519582A (ja) | 2016-06-29 | 2019-07-11 | オリオン コーポレーション | ベンゾジオキサン誘導体およびその医薬用途 |
CN114014844B (zh) * | 2016-07-20 | 2024-10-01 | 诺华股份有限公司 | 氨基吡啶衍生物及其作为选择性alk-2抑制剂的用途 |
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CN107382679A (zh) * | 2017-07-12 | 2017-11-24 | 安徽省诚联医药科技有限公司 | 达格列净中间体的制备方法 |
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CN111225914B (zh) | 2017-07-24 | 2022-10-11 | 生命医药有限责任公司 | RORγ的抑制剂 |
CN107573311A (zh) * | 2017-08-09 | 2018-01-12 | 江苏工程职业技术学院 | 一种达格列净的合成方法 |
CN107556309B (zh) * | 2017-09-11 | 2020-12-01 | 浙江永宁药业股份有限公司 | 多取代四氢萘啶类化合物的药物用途及其制备方法 |
EP3822271A4 (fr) | 2018-07-03 | 2022-04-13 | Jiangsu Hengrui Medicine Co., Ltd. | Dérivé de pyridopyrimidine, son procédé de préparation et son utilisation médicale |
WO2021102258A1 (fr) | 2019-11-22 | 2021-05-27 | Incyte Corporation | Polythérapie comprenant un inhibiteur d'alk2 et un inhibiteur de jak2 |
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CN113754635B (zh) * | 2020-06-02 | 2024-06-21 | 成都康弘药业集团股份有限公司 | 稠环类化合物及其制备方法和用途 |
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US6228869B1 (en) | 1996-10-16 | 2001-05-08 | American Cyanamid Company | Ortho-sulfonamido bicyclic hydroxamic acids as matrix metalloproteinase and TACE inhibitors |
US6677355B1 (en) | 1999-08-18 | 2004-01-13 | Warner-Lambert Company | Hydroxamic acid compounds useful as matrix metalloproteinase inhibitors |
AU2001250850A1 (en) | 2000-03-17 | 2001-10-03 | Dupont Pharmaceuticals Company | Beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha |
SE0100902D0 (sv) | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
BR0208105A (pt) | 2001-03-15 | 2004-03-09 | Astrazeneca Ab | Inibidores de metaloproteinase |
DE60234028D1 (de) | 2001-05-25 | 2009-11-26 | Bristol Myers Squibb Co | Hydantion-derivate als hemmer von matrix-metalloproteinasen |
AU2002346729A1 (en) | 2001-12-20 | 2003-07-09 | Bristol-Myers Squibb Company | Barbituric acid derivatives as inhibitors of tnf-$g(a) converting enzyme (tace) and/or matrix metalloproteinases |
US7294624B2 (en) | 2001-12-20 | 2007-11-13 | Bristol Myers Squibb Company | Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases |
AU2003261319A1 (en) | 2002-08-01 | 2004-02-23 | Bristol-Myers Squibb Company | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme |
GB0221246D0 (en) | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Compounds |
GB0221250D0 (en) | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Compounds |
WO2004033632A2 (fr) * | 2002-10-04 | 2004-04-22 | Bristol-Myers Squibb Company | Derives d'hydantoine en tant qu'inhibiteurs de metalloproteinases matricielles et/ou de l'enzyme de conversion de tnf-alpha (tace) |
DE60329326D1 (de) | 2002-12-19 | 2009-10-29 | Vertex Pharma | Tace inhibitoren |
US7504424B2 (en) | 2004-07-16 | 2009-03-17 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
US7488745B2 (en) | 2004-07-16 | 2009-02-10 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
ATE478864T1 (de) | 2004-07-16 | 2010-09-15 | Schering Corp | Hydantoinderivate zur behandlung von entzündlichen erkrankungen |
PE20071240A1 (es) | 2006-01-17 | 2008-01-14 | Schering Corp | Compuestos derivados de hidantoina para el tratamiento de trastornos inflamatorios |
JP2010502617A (ja) | 2006-08-31 | 2010-01-28 | シェーリング コーポレイション | 抗菌物質として有用なヒダントイン誘導体 |
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- 2007-01-15 PE PE2007000041A patent/PE20071241A1/es not_active Application Discontinuation
- 2007-01-16 US US11/653,511 patent/US7524842B2/en active Active
- 2007-01-16 CA CA002637196A patent/CA2637196A1/fr not_active Abandoned
- 2007-01-16 TW TW096101540A patent/TW200738688A/zh unknown
- 2007-01-16 AU AU2007207707A patent/AU2007207707A1/en not_active Abandoned
- 2007-01-16 CA CA002637198A patent/CA2637198A1/fr not_active Abandoned
- 2007-01-16 EP EP07716634.6A patent/EP1973901B1/fr active Active
- 2007-01-16 WO PCT/US2007/001025 patent/WO2007084451A1/fr active Application Filing
- 2007-01-16 JP JP2008551312A patent/JP2009523797A/ja not_active Withdrawn
- 2007-01-16 EP EP07716637.9A patent/EP1973900B1/fr active Active
- 2007-01-16 US US11/653,798 patent/US7683088B2/en active Active
- 2007-01-16 RU RU2008133383/04A patent/RU2008133383A/ru not_active Application Discontinuation
- 2007-01-16 AU AU2007207711A patent/AU2007207711A1/en not_active Abandoned
- 2007-01-16 CN CNA2007800091850A patent/CN101405286A/zh active Pending
- 2007-01-16 BR BRPI0706599-0A patent/BRPI0706599A2/pt not_active IP Right Cessation
- 2007-01-16 RU RU2008133382/04A patent/RU2008133382A/ru not_active Application Discontinuation
- 2007-01-16 BR BRPI0706598-1A patent/BRPI0706598A2/pt not_active IP Right Cessation
- 2007-01-16 TW TW096101542A patent/TW200736247A/zh unknown
- 2007-01-16 KR KR1020087019785A patent/KR20080085222A/ko not_active Application Discontinuation
- 2007-01-16 CN CNA2007800091278A patent/CN101410390A/zh active Pending
- 2007-01-16 KR KR1020087019782A patent/KR20080085221A/ko not_active Application Discontinuation
- 2007-01-16 JP JP2008551310A patent/JP2009523796A/ja not_active Withdrawn
- 2007-01-16 WO PCT/US2007/001030 patent/WO2007084455A1/fr active Application Filing
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2008
- 2008-07-08 IL IL192690A patent/IL192690A0/en unknown
- 2008-07-08 IL IL192691A patent/IL192691A0/en unknown
- 2008-07-11 ZA ZA200806072A patent/ZA200806072B/xx unknown
- 2008-07-16 EC EC2008008625A patent/ECSP088625A/es unknown
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- 2008-08-15 NO NO20083567A patent/NO20083567L/no not_active Application Discontinuation
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- 2009-02-03 US US12/364,845 patent/US7772263B2/en active Active
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