ZA200805606B - Mouth dissolving pharmaceutical composition and process for preparing the same using a high amount of silicon dioxide - Google Patents
Mouth dissolving pharmaceutical composition and process for preparing the same using a high amount of silicon dioxideInfo
- Publication number
- ZA200805606B ZA200805606B ZA200805606A ZA200805606A ZA200805606B ZA 200805606 B ZA200805606 B ZA 200805606B ZA 200805606 A ZA200805606 A ZA 200805606A ZA 200805606 A ZA200805606 A ZA 200805606A ZA 200805606 B ZA200805606 B ZA 200805606B
- Authority
- ZA
- South Africa
- Prior art keywords
- preparing
- pharmaceutical composition
- silicon dioxide
- same
- high amount
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN3482DE2005 | 2005-12-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200805606B true ZA200805606B (en) | 2009-11-25 |
Family
ID=38040253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200805606A ZA200805606B (en) | 2005-12-27 | 2008-06-26 | Mouth dissolving pharmaceutical composition and process for preparing the same using a high amount of silicon dioxide |
Country Status (6)
Country | Link |
---|---|
US (1) | US8048449B2 (xx) |
EP (1) | EP1978939A2 (xx) |
JP (1) | JP2009521523A (xx) |
BR (1) | BRPI0620578A2 (xx) |
WO (1) | WO2007074472A2 (xx) |
ZA (1) | ZA200805606B (xx) |
Families Citing this family (61)
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US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
NZ527142A (en) | 2003-07-23 | 2006-03-31 | Douglas Pharmaceuticals Ltd | A stable suspension formulation |
WO2006002421A2 (en) | 2004-06-24 | 2006-01-05 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
US9757455B2 (en) | 2005-11-28 | 2017-09-12 | Johnson & Johnson Consumer Inc. | Oral therapeutic compound delivery system |
ES2624554T3 (es) | 2005-12-28 | 2017-07-14 | Vertex Pharmaceuticals Incorporated | Formas sólidas de n- [2,4 - bis (1,1 - dimetiletil) - 5 - hidroxifenil] - 1,4 - dihidro - 4 - oxoquinolina - 3 - carboxamida |
ES2602784T3 (es) | 2007-02-23 | 2017-02-22 | Gilead Sciences, Inc. | Moduladores de las propiedades farmacocinéticas de los agentes terapéuticos |
AU2009242451C1 (en) | 2008-05-02 | 2017-05-18 | Gilead Sciences, Inc. | The use of solid carrier particles to improve the processability of a pharmaceutical agent |
CN102164508B (zh) * | 2008-07-31 | 2015-04-01 | 嘉康利公司 | 具有增加的抗氧化活性的麝香葡萄组合物 |
US9132162B2 (en) | 2008-07-31 | 2015-09-15 | Shaklee Corporation | Muscadine compositions with anti-oxidant activity |
US9173916B2 (en) | 2008-07-31 | 2015-11-03 | Shaklee Corporation | Method of preparing a muscadine pomace extract |
CN102164607B (zh) | 2008-07-31 | 2013-04-24 | 嘉康利公司 | 麝香葡萄果渣提取物的制备方法 |
EP2198857A1 (en) | 2008-12-19 | 2010-06-23 | Ratiopharm GmbH | Oral dispersible tablet |
US20100179202A1 (en) * | 2009-01-14 | 2010-07-15 | Ajanta Pharma Limited. | Orally disintegrating composition of zolmitriptan |
CA2756031C (en) | 2009-03-20 | 2018-01-02 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
EP2241179B1 (en) * | 2009-04-16 | 2017-05-17 | DeLaval Holding AB | A milking parlour and method for operating the same |
TR200903293A1 (tr) * | 2009-04-28 | 2010-11-22 | Sanovel İlaç San. Ve Ti̇c. A.Ş. | Oral yolla dağılan olanzapin tablet. |
US20100285164A1 (en) * | 2009-05-11 | 2010-11-11 | Jrs Pharma | Orally Disintegrating Excipient |
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UY32836A (es) | 2009-08-12 | 2011-03-31 | Bayer Schering Pharma Ag | Partículas estabilizadas que comprenden 5-metil-(6s)-tetrahidrofolato |
KR20120056824A (ko) | 2009-08-19 | 2012-06-04 | 바이엘 파마 악티엔게젤샤프트 | 소아과 용도를 위한 약물 전달 시스템 (웨이퍼) |
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EP2482822B1 (en) | 2009-10-01 | 2018-08-01 | Adare Pharmaceuticals, Inc. | Orally administered corticosteroid compositions |
TR201002084A1 (tr) * | 2010-03-19 | 2011-10-21 | Sanovel İlaç Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ | Oral yolla dağılan donepezil tablet formülasyonları ve hazırlama yöntemi |
JP2011213606A (ja) * | 2010-03-31 | 2011-10-27 | Sawai Pharmaceutical Co Ltd | ドネペジルを含有する固形製剤の製造方法 |
JP2011213695A (ja) * | 2010-04-02 | 2011-10-27 | Taisho Pharm Ind Ltd | ドネペジル塩酸塩含有口腔内速崩壊錠 |
WO2012027731A2 (en) * | 2010-08-27 | 2012-03-01 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
BR112014021090B1 (pt) * | 2012-02-27 | 2023-01-24 | Vertex Pharmaceuticals Incorporated | Composição farmacêutica e uso de n-[2,4-bis(1,1-dimetiletil)-5-hidróxifenil]-1,4-di-hidro-4-oxoquinolina3-carboxamida na preparação da mesma |
WO2013129436A1 (ja) * | 2012-02-29 | 2013-09-06 | 武田薬品工業株式会社 | 経口剤 |
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EP2934492A4 (en) * | 2012-12-21 | 2016-08-17 | Teva Pharma | TRANSMUCOSAL ADMINISTRATION OF GLATIRAMERATE ACETATE |
US20150025112A1 (en) * | 2013-07-19 | 2015-01-22 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Orally disintegrating tablet formulations of donepezil |
EP2829269A1 (en) * | 2013-07-22 | 2015-01-28 | Sanovel Ilac Sanayi ve Ticaret A.S. | Orally Disintegrating Tablet Formulation Comprising Flurbiprofen |
WO2015034678A2 (en) | 2013-09-06 | 2015-03-12 | Aptalis Pharmatech, Inc. | Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis |
EP2845850A1 (en) | 2013-09-10 | 2015-03-11 | ObsEva S.A. | Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists |
KR101881074B1 (ko) * | 2013-11-13 | 2018-08-17 | 내셔널 디펜스 에듀케이션 앤드 리서치 파운데이션 | 간에 대한 부작용이 없는 신규의 아세트아미노펜 화합물 조성물 |
EP2886107A1 (en) * | 2013-12-17 | 2015-06-24 | ObsEva S.A. | Oral formulations of pyrrolydine derivatives |
WO2016057730A1 (en) | 2014-10-07 | 2016-04-14 | Strohmeier Mark | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
ES2751300T3 (es) | 2014-11-21 | 2020-03-31 | Biohaven Therapeutics Ltd | Formulación sublingual de riluzol |
CN106606497B (zh) * | 2015-10-21 | 2019-12-31 | 浙江海力生制药有限公司 | 一种孟鲁司特钠泡腾制剂及其制备方法 |
EA201892587A1 (ru) | 2016-05-20 | 2019-04-30 | Биохэйвен Фармасьютикал Холдинг Компани Лтд. | Использование глутамат-модулирующих средств вместе с иммунотерапией для лечения рака |
TW201808323A (zh) | 2016-07-19 | 2018-03-16 | 美商嘉康利公司 | 具有低含量之縮合單寧分子的麝香葡萄局部組成物 |
TWI777515B (zh) | 2016-08-18 | 2022-09-11 | 美商愛戴爾製藥股份有限公司 | 治療嗜伊紅性食道炎之方法 |
CN106309391A (zh) * | 2016-09-23 | 2017-01-11 | 万特制药(海南)有限公司 | 一种可提高孟鲁司特钠稳定性的口崩片及其制备方法 |
SG10202107367SA (en) | 2016-12-31 | 2021-08-30 | Bioxcel Therapeutics Inc | Use of sublingual dexmedetomidine for the treatment of agitation |
CA3082096A1 (en) | 2017-11-12 | 2019-05-16 | Biohaven Pharmaceutical Holding Company Ltd. | Use of riluzole prodrugs to treat ataxias |
US11058633B2 (en) * | 2018-05-17 | 2021-07-13 | Fertin Pharma A/S | Disintegrating oral tablet suitable for active pharmaceutical ingredients |
JP6858729B2 (ja) * | 2018-05-25 | 2021-04-14 | ▲財▼▲団▼法人国防教育研究基金会National Defense Education And Research Foundation | 肝臓に対する副作用がない、新しいアセトアミノフェン複合組成 |
MX2020014000A (es) | 2018-06-27 | 2021-06-15 | Bioxcel Therapeutics Inc | Formulaciones en lámina que contienen dexmedetomidina y métodos para producirlas. |
KR20210042412A (ko) | 2018-09-06 | 2021-04-19 | 주식회사 이노파마스크린 | 천식 또는 파킨슨병 치료를 위한 방법 및 조성물 |
MX2021009679A (es) | 2019-02-22 | 2021-09-10 | Catalent Uk Swindon Zydis Ltd | Minimizacion de aglomeracion, aireacion y conservacion del revestimiento de composiciones farmaceuticas que comprenden ibuprofeno. |
US20200268677A1 (en) * | 2019-02-22 | 2020-08-27 | Catalent U.K. Swindon Zydis Limited | Minimizing aeration of suspensions during in-line mixing |
MX2021009844A (es) * | 2019-02-22 | 2021-09-10 | Catalent Uk Swindon Zydis Ltd | Conservacion de particulas de ingredientes farmaceuticos activos revestidas funcionalmente producidas mediante procesos de mezcla sin solvente en suspension acuosa. |
AU2020225448A1 (en) * | 2019-02-22 | 2021-10-14 | Catalent U.K. Swindon Zydis Limited | Minimizing agglomeration of drug particle coating material during storage to stabilize disintegration times of pharmaceutical products |
CA3145388A1 (en) | 2019-07-19 | 2021-01-28 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
JP2023525277A (ja) * | 2020-05-08 | 2023-06-15 | フェルティン ファルマ アー/エス | 口腔ケア利益のための洗口剤 |
US11291701B1 (en) * | 2021-02-04 | 2022-04-05 | Seed Edibles | Orally disintegrating, sublingual and buccal formulations |
CN114288258A (zh) * | 2022-02-18 | 2022-04-08 | 山东新时代药业有限公司 | 一种单硝酸异山梨酯片及其制备方法 |
CN116077450A (zh) * | 2022-12-24 | 2023-05-09 | 东北农业大学 | 一种米氮平掩味口崩片及其制备方法与应用 |
US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
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US5178878A (en) | 1989-10-02 | 1993-01-12 | Cima Labs, Inc. | Effervescent dosage form with microparticles |
US5188825A (en) | 1989-12-28 | 1993-02-23 | Iles Martin C | Freeze-dried dosage forms and methods for preparing the same |
EP1166801A1 (en) | 1993-06-04 | 2002-01-02 | Warner-Lambert Company | Preparations containing silicon dioxide to improve the taste thereof |
CA2166891C (en) | 1993-07-09 | 2001-07-03 | Sang K. Wong | Method for making freeze dried drug dosage forms |
GB9421836D0 (en) | 1994-10-28 | 1994-12-14 | Scherer Corp R P | Process for preparing solid pharmaceutical dosage forms of hydrophobic substances |
US6024981A (en) | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
US6080427A (en) | 1997-04-17 | 2000-06-27 | Bristol-Myers Squibb Company | Cefadroxil monohydrate tablet formulation |
US5976577A (en) | 1997-07-11 | 1999-11-02 | Rp Scherer Corporation | Process for preparing fast dispersing solid oral dosage form |
US20020071864A1 (en) * | 1999-03-25 | 2002-06-13 | Yuhan Corporation | Rapidly disintegrable tablet for oral administration |
WO2000078292A1 (fr) * | 1999-06-18 | 2000-12-28 | Takeda Chemical Industries, Ltd. | Preparations solides a desintegration rapide |
US20020076437A1 (en) * | 2000-04-12 | 2002-06-20 | Sanjeev Kothari | Flashmelt oral dosage formulation |
KR20010107754A (ko) * | 2000-05-26 | 2001-12-07 | 민경윤 | 경구투여용 속용정의 제조 방법 |
US6814978B2 (en) | 2000-12-29 | 2004-11-09 | Mcneil-Ppc, Inc. | Process for preparing a soft tablet |
FR2824477B1 (fr) * | 2001-05-09 | 2005-09-09 | Ethypharm Lab Prod Ethiques | Granules enrobes a base d'inhibiteur de l'enzyme de conversion de l'anfiotensine, leur procede de preparation et comprimes orodispersibles contenant les granules enrobes |
US20030215502A1 (en) * | 2002-03-20 | 2003-11-20 | Elan Pharma International Limited | Fast dissolving dosage forms having reduced friability |
EP1587496B1 (en) * | 2003-01-30 | 2009-10-07 | Ethypharm | Taste-masking coated particles, process for the preparation thereof and orodispersible tablets containing said coated particles |
US20050244343A1 (en) | 2004-04-30 | 2005-11-03 | Withiam Michael C | Oral care products comprising silica |
WO2006058250A2 (en) * | 2004-11-24 | 2006-06-01 | Spi Pharma, Inc. | Orally disintegrating compositions |
-
2006
- 2006-08-30 WO PCT/IN2006/000319 patent/WO2007074472A2/en active Application Filing
- 2006-08-30 EP EP06796197A patent/EP1978939A2/en not_active Withdrawn
- 2006-08-30 US US12/097,813 patent/US8048449B2/en not_active Expired - Fee Related
- 2006-08-30 BR BRPI0620578-0A patent/BRPI0620578A2/pt not_active IP Right Cessation
- 2006-08-30 JP JP2008548082A patent/JP2009521523A/ja not_active Withdrawn
-
2008
- 2008-06-26 ZA ZA200805606A patent/ZA200805606B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
WO2007074472A3 (en) | 2007-08-16 |
EP1978939A2 (en) | 2008-10-15 |
WO2007074472A2 (en) | 2007-07-05 |
JP2009521523A (ja) | 2009-06-04 |
US20080317853A1 (en) | 2008-12-25 |
US8048449B2 (en) | 2011-11-01 |
BRPI0620578A2 (pt) | 2011-12-06 |
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