ZA200805336B - Process for the enantioselective enzymatic reduction of hydroxyketo compounds - Google Patents

Process for the enantioselective enzymatic reduction of hydroxyketo compounds

Info

Publication number
ZA200805336B
ZA200805336B ZA200805336A ZA200805336A ZA200805336B ZA 200805336 B ZA200805336 B ZA 200805336B ZA 200805336 A ZA200805336 A ZA 200805336A ZA 200805336 A ZA200805336 A ZA 200805336A ZA 200805336 B ZA200805336 B ZA 200805336B
Authority
ZA
South Africa
Prior art keywords
hydroxy ketone
alkyl
general formula
enzymatic reduction
enantioselective enzymatic
Prior art date
Application number
ZA200805336A
Other languages
English (en)
Inventor
Antje Gupta
Maria Bobkova
Anke Tschentscher
Original Assignee
Iep Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iep Gmbh filed Critical Iep Gmbh
Publication of ZA200805336B publication Critical patent/ZA200805336B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/24Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26Ketones
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/002Nitriles (-CN)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/62Carboxylic acid esters
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0008Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA200805336A 2005-12-19 2006-12-14 Process for the enantioselective enzymatic reduction of hydroxyketo compounds ZA200805336B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0202705A AT503017B1 (de) 2005-12-19 2005-12-19 Verfahren zur enantioselektiven enzymatischen reduktion von hydroxyketoverbindungen

Publications (1)

Publication Number Publication Date
ZA200805336B true ZA200805336B (en) 2009-12-30

Family

ID=37900660

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200805336A ZA200805336B (en) 2005-12-19 2006-12-14 Process for the enantioselective enzymatic reduction of hydroxyketo compounds

Country Status (17)

Country Link
US (2) US8980592B2 (xx)
EP (1) EP1963516B1 (xx)
JP (1) JP5328365B2 (xx)
KR (1) KR101344605B1 (xx)
CN (1) CN101432435A (xx)
AT (2) AT503017B1 (xx)
AU (1) AU2006331069B2 (xx)
CA (1) CA2633583C (xx)
DE (1) DE502006008961D1 (xx)
DK (1) DK1963516T3 (xx)
ES (1) ES2363374T3 (xx)
PL (1) PL1963516T3 (xx)
PT (1) PT1963516E (xx)
SI (1) SI1963516T1 (xx)
TW (1) TWI408234B (xx)
WO (1) WO2007073875A1 (xx)
ZA (1) ZA200805336B (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT504542B1 (de) * 2006-12-07 2008-09-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von secodionderivaten
TWI601825B (zh) * 2007-09-27 2017-10-11 Iep有限公司 對映異構選擇性酶催化還原中間產物之方法
CN101429514B (zh) * 2007-11-08 2011-06-15 陈依军 一种双羰基还原酶、其基因及其应用
EP2226386A1 (de) * 2009-03-05 2010-09-08 IEP GmbH Verfahren zur stereoselektiven enzymatischen Reduktion von Ketoverbindungen
BRPI0924997B1 (pt) 2009-06-22 2024-01-16 Sk Biopharmaceuticals Co., Ltd Método para preparar um composto de éster do ácido 1-aril-2- tetrazoil etil carbâmico
US8404461B2 (en) 2009-10-15 2013-03-26 SK Biopharmaceutical Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
US20130289276A1 (en) * 2010-10-08 2013-10-31 Cadila Healthcare Limited Process for preparing an intermediate of sitagliptin via enzymatic conversion
AU2011343222B2 (en) * 2010-12-16 2016-09-29 Pharmazell Gmbh Novel 7B-hydroxysteroid dehydrogenase mutants and process for the preparation of ursodeoxycholic acid
EA027209B1 (ru) * 2012-06-18 2017-06-30 Лабораторио Кимико Интернационале С.П.А. Ферментативное восстановление
CN102978249A (zh) * 2012-11-19 2013-03-20 苏州汉酶生物技术有限公司 6-氰基-(3r,5r)-二羟基己酸叔丁酯的生物制备方法
CN103146591B (zh) * 2013-01-30 2014-08-27 浙江工业大学 生物还原制备他汀侧链6-氰基-(3r,5r)-二羟基己酸叔丁酯及菌株
CN104342410B (zh) * 2013-07-26 2017-04-19 南京朗恩生物科技有限公司 一种酮还原酶突变体及其制备方法
CN105713884A (zh) * 2014-12-02 2016-06-29 安琪酵母股份有限公司 生物催化氢化组合物及其合成罗素伐他汀手性中间体方法
US10745263B2 (en) 2015-05-28 2020-08-18 Sonicu, Llc Container fill level indication system using a machine learning algorithm
US20160348842A1 (en) 2015-05-28 2016-12-01 Sonicu, Llc Liquid container refill remote management system
CN109913514A (zh) * 2019-03-12 2019-06-21 江苏理工学院 一种固定化酶流化床连续催化合成ats-7的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5324662A (en) 1992-05-15 1994-06-28 E. R. Squibb & Sons, Inc. Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
GB9512837D0 (en) * 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
CA2360376C (en) * 1999-12-03 2005-04-26 Noriyuki Kizaki Novel carbonyl reductase, gene thereof and method of using the same
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
AU2003214111A1 (en) * 2002-03-18 2003-09-29 Ciba Specialty Chemicals Holding Inc. Alcohol dehydrogenases with high solvent and temperature stability
DE10327454A1 (de) 2003-06-18 2005-01-20 Juelich Enzyme Products Gmbh Oxidoreduktase aus Pichia capsulata
AT413541B (de) 2004-05-10 2006-03-15 Iep Gmbh Verfahren zur herstellung von 2-butanol

Also Published As

Publication number Publication date
AT503017B1 (de) 2007-07-15
KR20080087000A (ko) 2008-09-29
AU2006331069B2 (en) 2012-04-05
CA2633583C (en) 2016-06-21
PT1963516E (pt) 2011-05-25
CN101432435A (zh) 2009-05-13
DK1963516T3 (da) 2011-06-06
ES2363374T3 (es) 2011-08-02
KR101344605B1 (ko) 2013-12-26
US20150152451A1 (en) 2015-06-04
EP1963516A1 (de) 2008-09-03
US9228214B2 (en) 2016-01-05
PL1963516T3 (pl) 2011-07-29
TW200801196A (en) 2008-01-01
US8980592B2 (en) 2015-03-17
SI1963516T1 (sl) 2011-06-30
TWI408234B (zh) 2013-09-11
JP2009519722A (ja) 2009-05-21
CA2633583A1 (en) 2007-07-05
WO2007073875A1 (de) 2007-07-05
AT503017A4 (de) 2007-07-15
JP5328365B2 (ja) 2013-10-30
DE502006008961D1 (de) 2011-04-07
EP1963516B1 (de) 2011-02-23
ATE499447T1 (de) 2011-03-15
US20090221044A1 (en) 2009-09-03
AU2006331069A1 (en) 2007-07-05

Similar Documents

Publication Publication Date Title
ZA200805336B (en) Process for the enantioselective enzymatic reduction of hydroxyketo compounds
Kroutil et al. Recent advances in the biocatalytic reduction of ketones and oxidation of sec-alcohols
Kroutil et al. Biocatalytic oxidation of primary and secondary alcohols
PH12014501770A1 (en) Method for enzymatic redox cofactor regeneration
Hollmann et al. Enzyme-mediated oxidations for the chemist
Maicas et al. NAD (P) H regeneration is the key for heterolactic fermentation of hexoses in Oenococcus oeni
Rodriguez et al. Recent advances in cofactor regeneration systems applied to biocatalyzed oxidative processes
EP1179595A4 (en) (R) -2-OCTANOL DEHYDROGENASES, PRODUCTION OF SUCH ENZYMES, DNA ENCODING THESE ENZYMES, AND PRODUCTION OF ALCOHOLS USING SUCH ENZYMES
Geng et al. Heme-dependent dioxygenases in tryptophan oxidation
WO2008068030A3 (de) Verfahren zur herstellung von secolderivaten durch enantioselektive enzymatische reduktion von secodionderivaten unter verwendung einer oxidoreduktase/dehydrogenase in gegenwart von nadh oder nadph
WO2010051527A3 (en) Engineered microorganisms capable of producing target compounds under anaerobic conditions
EP1674578A4 (en) PROCESS FOR THE PREPARATION OF SCYLLO INOSITOL
Aksu et al. A new regeneration system for oxidized nicotinamide cofactors
KR101275061B1 (ko) 거울상이성질체 선택적인 효소에 의한 케토 화합물의 환원방법
ATE515571T1 (de) Verfahren zur herstellung von optisch aktiven sekundären alkoholen aus ketonen unter verwendung einer adsorbierten carbonylreduktase-aktivität
BR0316552A (pt) Microorganismos metabolicamente engenheirado e geneticamente transformado, e, método para produzir um produto metabólico desejado
Wunderer et al. The glutamyl tail length of the cofactor F420 in the methanogenic Archaea Methanosarcina thermophila and Methanoculleus thermophilus
WO2010139651A2 (en) A process for the enzymatic reduction of enoates
RU2002134073A (ru) Способ, включающий непрямую электрохимическую регенерацию n a d (p) h
Valton et al. An aromatic hydroxylation reaction catalyzed by a two-component FMN-dependent monooxygenase: the ActVA-ActVB system from Streptomyces coelicolor
AU2002224874A1 (en) Method for producing alcoxylated carbonyl compounds by an anodic oxidation method using a cathodic coupled reaction for organic synthesis
WO2007022504A3 (en) Conversion of carbon dioxide to methanol in silica sol-gel matrix
Runda et al. Developing hybrid systems to address oxygen uncoupling in multi-component Rieske oxygenases
Sato et al. Deracemization of 1-phenylethanols in a one-pot process combining Mn-driven oxidation with enzymatic reduction utilizing a compartmentalization technique
WO2009041415A1 (ja) 新規グルコース脱水素酵素