DK1963516T3 - Fremgangsmåde til enantioselektiv enzymatisk reduktion af hydroxyketoforbindelser - Google Patents

Fremgangsmåde til enantioselektiv enzymatisk reduktion af hydroxyketoforbindelser

Info

Publication number
DK1963516T3
DK1963516T3 DK06819032.1T DK06819032T DK1963516T3 DK 1963516 T3 DK1963516 T3 DK 1963516T3 DK 06819032 T DK06819032 T DK 06819032T DK 1963516 T3 DK1963516 T3 DK 1963516T3
Authority
DK
Denmark
Prior art keywords
hydroxy ketone
alkyl
general formula
enzymatic reduction
enantioselective enzymatic
Prior art date
Application number
DK06819032.1T
Other languages
English (en)
Inventor
Maria Bobkova
Antje Gupta
Anke Tschentscher
Original Assignee
Iep Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iep Gmbh filed Critical Iep Gmbh
Application granted granted Critical
Publication of DK1963516T3 publication Critical patent/DK1963516T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK06819032.1T 2005-12-19 2006-12-14 Fremgangsmåde til enantioselektiv enzymatisk reduktion af hydroxyketoforbindelser DK1963516T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0202705A AT503017B1 (de) 2005-12-19 2005-12-19 Verfahren zur enantioselektiven enzymatischen reduktion von hydroxyketoverbindungen
PCT/EP2006/012037 WO2007073875A1 (de) 2005-12-19 2006-12-14 Verfahren zur enantioselektiven enzymatischen reduktion von hydroxyketoverbindungen

Publications (1)

Publication Number Publication Date
DK1963516T3 true DK1963516T3 (da) 2011-06-06

Family

ID=37900660

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06819032.1T DK1963516T3 (da) 2005-12-19 2006-12-14 Fremgangsmåde til enantioselektiv enzymatisk reduktion af hydroxyketoforbindelser

Country Status (17)

Country Link
US (2) US8980592B2 (da)
EP (1) EP1963516B1 (da)
JP (1) JP5328365B2 (da)
KR (1) KR101344605B1 (da)
CN (1) CN101432435A (da)
AT (2) AT503017B1 (da)
AU (1) AU2006331069B2 (da)
CA (1) CA2633583C (da)
DE (1) DE502006008961D1 (da)
DK (1) DK1963516T3 (da)
ES (1) ES2363374T3 (da)
PL (1) PL1963516T3 (da)
PT (1) PT1963516E (da)
SI (1) SI1963516T1 (da)
TW (1) TWI408234B (da)
WO (1) WO2007073875A1 (da)
ZA (1) ZA200805336B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT504542B1 (de) * 2006-12-07 2008-09-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von secodionderivaten
TWI601825B (zh) * 2007-09-27 2017-10-11 Ｉｅｐ有限公司 對映異構選擇性酶催化還原中間產物之方法
CN101429514B (zh) * 2007-11-08 2011-06-15 陈依军 一种双羰基还原酶、其基因及其应用
EP2226386A1 (de) * 2009-03-05 2010-09-08 IEP GmbH Verfahren zur stereoselektiven enzymatischen Reduktion von Ketoverbindungen
MY155662A (en) 2009-06-22 2015-11-13 Sk Biopharmaceuticals Co Ltd Method for preparation of carbamic acid (r)-1-aryl-2-tetrazolyl-ethyl ester
US8404461B2 (en) * 2009-10-15 2013-03-26 SK Biopharmaceutical Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
US20130289276A1 (en) * 2010-10-08 2013-10-31 Cadila Healthcare Limited Process for preparing an intermediate of sitagliptin via enzymatic conversion
US20140087421A1 (en) * 2010-12-16 2014-03-27 Pharmazell Gmbh NOVEL 7Beta-HYDROXYSTEROID DEHYDROGENASE MUTANTS AND PROCESS FOR THE PREPARATION OF URSODEOXYCHOLIC ACID
EP2861750B1 (en) * 2012-06-18 2016-11-23 Laboratorio Chimico Internazionale S.p.A. Process for producing chiral 1-substituted 3-piperidinols employing oxidoreductases
CN102978249A (zh) * 2012-11-19 2013-03-20 苏州汉酶生物技术有限公司 6-氰基-（3r,5r）-二羟基己酸叔丁酯的生物制备方法
CN103146591B (zh) * 2013-01-30 2014-08-27 浙江工业大学 生物还原制备他汀侧链6-氰基-(3r,5r)-二羟基己酸叔丁酯及菌株
CN104342410B (zh) * 2013-07-26 2017-04-19 南京朗恩生物科技有限公司 一种酮还原酶突变体及其制备方法
CN105713884A (zh) * 2014-12-02 2016-06-29 安琪酵母股份有限公司 生物催化氢化组合物及其合成罗素伐他汀手性中间体方法
US20160348842A1 (en) 2015-05-28 2016-12-01 Sonicu, Llc Liquid container refill remote management system
US10745263B2 (en) 2015-05-28 2020-08-18 Sonicu, Llc Container fill level indication system using a machine learning algorithm
CN109913514A (zh) * 2019-03-12 2019-06-21 江苏理工学院 一种固定化酶流化床连续催化合成ats-7的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5324662A (en) 1992-05-15 1994-06-28 E. R. Squibb & Sons, Inc. Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
GB9512837D0 (en) * 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
JP4510351B2 (ja) * 1999-12-03 2010-07-21 株式会社カネカ 新規カルボニル還元酵素、その遺伝子、およびその利用法
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
CA2474905A1 (en) * 2002-03-18 2003-09-25 Ciba Specialty Chemicals Holding Inc. Alcohol dehydrogenases with high solvent and temperature stability
DE10327454A1 (de) * 2003-06-18 2005-01-20 Juelich Enzyme Products Gmbh Oxidoreduktase aus Pichia capsulata
AT413541B (de) * 2004-05-10 2006-03-15 Iep Gmbh Verfahren zur herstellung von 2-butanol

Also Published As

Publication number Publication date
AT503017B1 (de) 2007-07-15
KR101344605B1 (ko) 2013-12-26
WO2007073875A1 (de) 2007-07-05
AU2006331069A1 (en) 2007-07-05
TWI408234B (zh) 2013-09-11
DE502006008961D1 (de) 2011-04-07
PL1963516T3 (pl) 2011-07-29
JP5328365B2 (ja) 2013-10-30
KR20080087000A (ko) 2008-09-29
US20150152451A1 (en) 2015-06-04
AU2006331069B2 (en) 2012-04-05
ES2363374T3 (es) 2011-08-02
ATE499447T1 (de) 2011-03-15
SI1963516T1 (sl) 2011-06-30
JP2009519722A (ja) 2009-05-21
US20090221044A1 (en) 2009-09-03
PT1963516E (pt) 2011-05-25
CA2633583A1 (en) 2007-07-05
US9228214B2 (en) 2016-01-05
EP1963516A1 (de) 2008-09-03
CA2633583C (en) 2016-06-21
AT503017A4 (de) 2007-07-15
TW200801196A (en) 2008-01-01
CN101432435A (zh) 2009-05-13
US8980592B2 (en) 2015-03-17
EP1963516B1 (de) 2011-02-23
ZA200805336B (en) 2009-12-30

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