ZA200800320B - Indol-3-carbonyl-spiro-piperidine derivatives as Via receptor antagonists - Google Patents

Indol-3-carbonyl-spiro-piperidine derivatives as Via receptor antagonists

Info

Publication number
ZA200800320B
ZA200800320B ZA200800320A ZA200800320A ZA200800320B ZA 200800320 B ZA200800320 B ZA 200800320B ZA 200800320 A ZA200800320 A ZA 200800320A ZA 200800320 A ZA200800320 A ZA 200800320A ZA 200800320 B ZA200800320 B ZA 200800320B
Authority
ZA
South Africa
Prior art keywords
indol
spiro
carbonyl
receptor antagonists
piperidine derivatives
Prior art date
Application number
ZA200800320A
Other languages
English (en)
Inventor
Bissantz Caterina
Ratni Hasane
Schnider Patrick
Grundschober Christophe
Rogers-Evans Mark
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA200800320B publication Critical patent/ZA200800320B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA200800320A 2005-07-14 2008-01-10 Indol-3-carbonyl-spiro-piperidine derivatives as Via receptor antagonists ZA200800320B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05106443 2005-07-14
EP05109364 2005-10-07

Publications (1)

Publication Number Publication Date
ZA200800320B true ZA200800320B (en) 2009-02-25

Family

ID=37001896

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200800320A ZA200800320B (en) 2005-07-14 2008-01-10 Indol-3-carbonyl-spiro-piperidine derivatives as Via receptor antagonists

Country Status (26)

Country Link
US (2) US7332501B2 (xx)
EP (1) EP1904477B1 (xx)
JP (1) JP4927079B2 (xx)
KR (1) KR100974967B1 (xx)
CN (1) CN101253164B (xx)
AR (1) AR054830A1 (xx)
AT (1) ATE421511T1 (xx)
AU (1) AU2006268724B2 (xx)
BR (1) BRPI0612988A2 (xx)
CA (1) CA2615726C (xx)
CY (1) CY1108996T1 (xx)
DE (1) DE602006004997D1 (xx)
DK (1) DK1904477T3 (xx)
ES (1) ES2317558T3 (xx)
HK (1) HK1123554A1 (xx)
IL (1) IL188478A (xx)
MX (1) MX2008000585A (xx)
MY (1) MY144684A (xx)
NO (1) NO20080059L (xx)
PL (1) PL1904477T3 (xx)
PT (1) PT1904477E (xx)
RU (1) RU2414466C2 (xx)
SI (1) SI1904477T1 (xx)
TW (1) TWI312780B (xx)
WO (1) WO2007006688A1 (xx)
ZA (1) ZA200800320B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602006004997D1 (de) * 2005-07-14 2009-03-12 Hoffmann La Roche Indol-3-carbonyl-spiro-piperidinderivate als antagonisten des v1a-rezeptors
WO2007039438A1 (en) * 2005-09-28 2007-04-12 F. Hoffmann-La Roche Ag Indol-3-yl-carbonyl-azaspiro derivatives as vasopressin receptor antagonists
US7351706B2 (en) * 2006-01-05 2008-04-01 Hoffmann-La Roche Inc. Indol-3-yl-carbonyl-spiro-piperidine derivatives
RU2009119394A (ru) 2006-12-07 2011-01-20 Ф. Хоффманн-Ля Рош Аг (Ch) Производные спиро-пиперидина в качестве антагонистов рецептора v1a
US7799923B2 (en) 2006-12-08 2010-09-21 Hoffmann-La Roche Inc. Indoles
CA2673307A1 (en) * 2006-12-22 2008-07-03 F. Hoffman-La Roche Ag Spiro-piperidine derivatives
EP2104677B1 (en) * 2007-01-12 2011-12-07 F. Hoffmann-La Roche AG Spiropiperidine glycinamide derivatives
TW200940547A (en) * 2007-12-13 2009-10-01 Speedel Experimenta Ag Organic compounds
US8785634B2 (en) * 2010-04-26 2014-07-22 Merck Sharp & Dohme Corp Spiropiperidine prolylcarboxypeptidase inhibitors
AU2012226475C1 (en) 2011-03-10 2015-08-06 Zoetis Services Llc Spirocyclic isoxazoline derivatives as antiparasitic agents
RU2475489C1 (ru) * 2011-10-07 2013-02-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Чувашский государственный университет имени И.Н. Ульянова" Способ получения 8-амино-1-имино-6-морфолин-4-ил-2-окса-7-азаспиро[4,4]нона-3,6,8-триен-9-карбонитрилов
RS55166B1 (sr) 2012-03-16 2017-01-31 Vitae Pharmaceuticals Inc Modulatori x receptora iz jetre
LT2825542T (lt) 2012-03-16 2016-12-27 Vitae Pharmaceuticals, Inc. Kepenų x receptoriaus moduliatoriai
JO3109B1 (ar) * 2012-05-10 2017-09-20 Ferring Bv منبهات لمستقبلات v1a
KR101698124B1 (ko) * 2015-05-29 2017-01-19 한국외국어대학교 연구산학협력단 3-(메틸아미노)-3-((r)-피롤리딘-3-일)프로판니트릴 또는 이의 염의 제조방법
CN108884096B (zh) * 2016-02-08 2022-03-22 豪夫迈·罗氏有限公司 作为ddr1抑制剂的螺二氢吲哚酮
US20180002344A1 (en) 2016-06-16 2018-01-04 Genentech, Inc. Heteroaryl estrogen receptor modulators and uses thereof
CN110234631B (zh) 2016-09-21 2023-02-28 维克特斯生物系统有限公司 用于治疗高血压和/或纤维化的组合物
HU231206B1 (hu) 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek
TW201938171A (zh) 2017-12-15 2019-10-01 匈牙利商羅特格登公司 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物
CN113563255B (zh) * 2020-04-29 2023-08-18 成都倍特药业股份有限公司 瑞芬沙星中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686624A (en) * 1992-01-30 1997-11-11 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
EP1410437A2 (en) * 2001-01-22 2004-04-21 Morgan Chemical Products, Inc. Cvd diamond enhanced microprocessor cooling system
DE602006004997D1 (de) * 2005-07-14 2009-03-12 Hoffmann La Roche Indol-3-carbonyl-spiro-piperidinderivate als antagonisten des v1a-rezeptors

Also Published As

Publication number Publication date
RU2008100082A (ru) 2009-08-20
CN101253164B (zh) 2012-05-16
PT1904477E (pt) 2009-03-12
KR20080024231A (ko) 2008-03-17
DE602006004997D1 (de) 2009-03-12
CY1108996T1 (el) 2014-07-02
EP1904477A1 (en) 2008-04-02
ES2317558T3 (es) 2009-04-16
MX2008000585A (es) 2008-03-14
EP1904477B1 (en) 2009-01-21
CA2615726C (en) 2014-05-27
BRPI0612988A2 (pt) 2010-12-14
TW200726469A (en) 2007-07-16
SI1904477T1 (sl) 2009-06-30
IL188478A0 (en) 2008-04-13
US7332501B2 (en) 2008-02-19
KR100974967B1 (ko) 2010-08-09
CN101253164A (zh) 2008-08-27
WO2007006688A1 (en) 2007-01-18
US20080146557A1 (en) 2008-06-19
US7629353B2 (en) 2009-12-08
RU2414466C2 (ru) 2011-03-20
US20070027173A1 (en) 2007-02-01
DK1904477T3 (da) 2009-03-16
AU2006268724A1 (en) 2007-01-18
AR054830A1 (es) 2007-07-18
CA2615726A1 (en) 2007-01-18
HK1123554A1 (en) 2009-06-19
AU2006268724B2 (en) 2011-06-02
NO20080059L (no) 2008-04-02
TWI312780B (en) 2009-08-01
ATE421511T1 (de) 2009-02-15
PL1904477T3 (pl) 2009-07-31
MY144684A (en) 2011-10-31
JP4927079B2 (ja) 2012-05-09
IL188478A (en) 2012-01-31
JP2009501185A (ja) 2009-01-15

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