ZA200710969B - Raf inhibitor compounds and methods of use thereof - Google Patents

Raf inhibitor compounds and methods of use thereof

Info

Publication number
ZA200710969B
ZA200710969B ZA200710969A ZA200710969A ZA200710969B ZA 200710969 B ZA200710969 B ZA 200710969B ZA 200710969 A ZA200710969 A ZA 200710969A ZA 200710969 A ZA200710969 A ZA 200710969A ZA 200710969 B ZA200710969 B ZA 200710969B
Authority
ZA
South Africa
Prior art keywords
methods
inhibitor compounds
raf inhibitor
raf
compounds
Prior art date
Application number
ZA200710969A
Other languages
English (en)
Inventor
Laird Ellen
Joseph P Lyssikatos
Grina Jonas
Newhouse Brad
Topalov George
Welch Mike
Hansen Josh
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of ZA200710969B publication Critical patent/ZA200710969B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
ZA200710969A 2005-05-20 2007-12-18 Raf inhibitor compounds and methods of use thereof ZA200710969B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68317505P 2005-05-20 2005-05-20

Publications (1)

Publication Number Publication Date
ZA200710969B true ZA200710969B (en) 2009-03-25

Family

ID=37432152

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200710969A ZA200710969B (en) 2005-05-20 2007-12-18 Raf inhibitor compounds and methods of use thereof

Country Status (14)

Country Link
US (1) US7566716B2 (no)
EP (1) EP1902056A2 (no)
JP (1) JP2008540674A (no)
KR (1) KR20080038278A (no)
CN (1) CN101263142A (no)
AU (1) AU2006247118A1 (no)
BR (1) BRPI0610863A2 (no)
CA (1) CA2609299A1 (no)
IL (1) IL187509A0 (no)
MX (1) MX2007014510A (no)
NO (1) NO20076553L (no)
RU (1) RU2007147382A (no)
WO (1) WO2006125101A2 (no)
ZA (1) ZA200710969B (no)

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SG178899A1 (en) 2009-08-28 2012-04-27 Array Biopharma Inc Raf inhibitor compounds and methods of use thereof
CN102482283A (zh) 2009-08-28 2012-05-30 阵列生物制药公司 Raf抑制剂化合物及其使用方法
JP2013503188A (ja) 2009-08-28 2013-01-31 アレイ バイオファーマ、インコーポレイテッド Ｒａｆ阻害化合物およびその使用方法
CA2772575A1 (en) * 2009-08-28 2011-03-03 Genentech, Inc. Raf inhibitor compounds and methods of use thereof
US20120157452A1 (en) 2009-08-28 2012-06-21 Genentech, Inc. 1h-pyrazolo[3,4-b] pyridine compounds for inhibiting raf kinase
KR101233082B1 (ko) 2010-02-25 2013-02-14 주식회사 이큐스앤자루 신규한 이미다졸피라진 유도체 화합물 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 항바이러스 치료용 약학적 조성물
MY162903A (en) 2010-06-04 2017-07-31 Abraxis Bioscience Llc Methods of treatment of pancreatic cancer
CN102406646B (zh) * 2010-09-20 2015-09-09 北大方正集团有限公司 芳基脲衍生物用于制备治疗移植排斥药物的用途
US8937088B2 (en) 2011-01-06 2015-01-20 Astar Biotech Llc Ureas for the treatment and prevention of cancer
CN103596957B (zh) 2011-04-07 2016-12-07 拜耳知识产权有限责任公司 作为akt激酶抑制剂的咪唑并哒嗪
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
AU2011384857B2 (en) 2011-12-31 2016-03-03 Beigene, Ltd. Fused tricyclic compounds as Raf kinase inhibitors
WO2014206344A1 (en) 2013-06-28 2014-12-31 Beigene, Ltd. Fused tricyclic amide compounds as multiple kinase inhibitors
WO2015041534A1 (en) 2013-09-20 2015-03-26 Stichting Het Nederlands Kanker Instituut P90rsk in combination with raf/erk/mek
EP3046557A1 (en) 2013-09-20 2016-07-27 Stichting Het Nederlands Kanker Instituut Rock in combination with mapk-pathway
WO2015156674A2 (en) 2014-04-10 2015-10-15 Stichting Het Nederlands Kanker Instituut Method for treating cancer
WO2015178770A1 (en) 2014-05-19 2015-11-26 Stichting Het Nederlands Kanker Instituut Compositions for cancer treatment
MA52119A (fr) 2015-10-19 2018-08-29 Ncyte Corp Composés hétérocycliques utilisés comme immunomodulateurs
JP7148401B2 (ja) 2015-11-19 2022-10-05 インサイト・コーポレイション 免疫調節剤としての複素環化合物
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US20170320875A1 (en) 2016-05-06 2017-11-09 Incyte Corporation Heterocyclic compounds as immunomodulators
EP3464279B1 (en) 2016-05-26 2021-11-24 Incyte Corporation Heterocyclic compounds as immunomodulators
MX2018016273A (es) 2016-06-20 2019-07-04 Incyte Corp Compuestos heterociclicos como inmunomoduladores.
WO2018013789A1 (en) 2016-07-14 2018-01-18 Incyte Corporation Heterocyclic compounds as immunomodulators
EP3504198B1 (en) 2016-08-29 2023-01-25 Incyte Corporation Heterocyclic compounds as immunomodulators
HUE060233T2 (hu) 2016-12-22 2023-02-28 Incyte Corp Tetrahidro imidazo[4,5-c]piridin-származékok mint a PD-L1 internalizációját indukáló szerek
US20180179179A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Heterocyclic compounds as immunomodulators
EP3558989B1 (en) 2016-12-22 2021-04-14 Incyte Corporation Triazolo[1,5-a]pyridine derivatives as immunomodulators
BR112019012993A2 (pt) 2016-12-22 2019-12-03 Incyte Corp derivados de benzo-oxazol como imunomoduladores
JP7341060B2 (ja) 2017-02-10 2023-09-08 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Ｍａｐｋ経路の活性化に関連付けられる癌の処置のための方法及び医薬組成物
EP3732285A1 (en) 2017-12-28 2020-11-04 Tract Pharmaceuticals, Inc. Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
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HUE061503T2 (hu) 2018-05-11 2023-07-28 Incyte Corp Tetrahidro-imidazo[4,5-C]piridin-származékok mint PD-L1 immunmodulátorok
JP2022544189A (ja) 2019-08-09 2022-10-17 インサイト・コーポレイション Ｐｄ－１／ｐｄ－ｌ１阻害剤の塩
WO2021067217A1 (en) 2019-09-30 2021-04-08 Incyte Corporation Pyrido[3,2-d]pyrimidine compounds as immunomodulators
BR112022009031A2 (pt) 2019-11-11 2022-10-11 Incyte Corp Sais e formas cristalinas de um inibidor de pd-1/pd-l1
TW202233615A (zh) 2020-11-06 2022-09-01 美商英塞特公司 Ｐｄ—１／ｐｄ—ｌ１抑制劑之結晶形式
US11780836B2 (en) 2020-11-06 2023-10-10 Incyte Corporation Process of preparing a PD-1/PD-L1 inhibitor
AR124001A1 (es) 2020-11-06 2023-02-01 Incyte Corp Proceso para fabricar un inhibidor pd-1 / pd-l1 y sales y formas cristalinas del mismo

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Also Published As

Publication number Publication date
WO2006125101A3 (en) 2007-03-29
IL187509A0 (en) 2008-03-20
RU2007147382A (ru) 2009-06-27
WO2006125101A2 (en) 2006-11-23
CN101263142A (zh) 2008-09-10
MX2007014510A (es) 2008-02-05
KR20080038278A (ko) 2008-05-06
EP1902056A2 (en) 2008-03-26
AU2006247118A1 (en) 2006-11-23
US7566716B2 (en) 2009-07-28
NO20076553L (no) 2008-02-19
BRPI0610863A2 (pt) 2010-08-03
US20060281751A1 (en) 2006-12-14
CA2609299A1 (en) 2006-11-23
JP2008540674A (ja) 2008-11-20

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