ZA200709088B - Hydrogenated benzo (c) thiophene derivatives as immunomodulators - Google Patents

Hydrogenated benzo (c) thiophene derivatives as immunomodulators

Info

Publication number
ZA200709088B
ZA200709088B ZA200709088A ZA200709088A ZA200709088B ZA 200709088 B ZA200709088 B ZA 200709088B ZA 200709088 A ZA200709088 A ZA 200709088A ZA 200709088 A ZA200709088 A ZA 200709088A ZA 200709088 B ZA200709088 B ZA 200709088B
Authority
ZA
South Africa
Prior art keywords
immunomodulators
thiophene derivatives
benzo
hydrogenated
hydrogenated benzo
Prior art date
Application number
ZA200709088A
Other languages
English (en)
Inventor
Bolli Martin
Mathys Boris
Nayler Oliver
Weller Thomas
Lehmann David
Mueller Claus
Velker Joerg
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of ZA200709088B publication Critical patent/ZA200709088B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
ZA200709088A 2005-03-23 2007-10-22 Hydrogenated benzo (c) thiophene derivatives as immunomodulators ZA200709088B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP2005003071 2005-03-23

Publications (1)

Publication Number Publication Date
ZA200709088B true ZA200709088B (en) 2008-09-25

Family

ID=36592888

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200709088A ZA200709088B (en) 2005-03-23 2007-10-22 Hydrogenated benzo (c) thiophene derivatives as immunomodulators

Country Status (26)

Country Link
US (2) US7723378B2 (ko)
EP (1) EP1863787B1 (ko)
JP (1) JP5047941B2 (ko)
KR (1) KR101382733B1 (ko)
CN (1) CN101180290B (ko)
AR (1) AR053452A1 (ko)
AT (1) ATE510831T1 (ko)
AU (1) AU2006226018B2 (ko)
BR (1) BRPI0609515A8 (ko)
CA (1) CA2602474C (ko)
CY (1) CY1111767T1 (ko)
DK (1) DK1863787T3 (ko)
ES (1) ES2365747T3 (ko)
HR (1) HRP20110613T1 (ko)
IL (1) IL186148A (ko)
MX (1) MX2007011670A (ko)
MY (1) MY147949A (ko)
NO (1) NO340192B1 (ko)
NZ (1) NZ562562A (ko)
PL (1) PL1863787T3 (ko)
PT (1) PT1863787E (ko)
RU (1) RU2412179C2 (ko)
SI (1) SI1863787T1 (ko)
TW (1) TWI402262B (ko)
WO (1) WO2006100631A1 (ko)
ZA (1) ZA200709088B (ko)

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Also Published As

Publication number Publication date
US20080176926A1 (en) 2008-07-24
TW200716591A (en) 2007-05-01
BRPI0609515A8 (pt) 2017-12-26
JP2008534490A (ja) 2008-08-28
CN101180290A (zh) 2008-05-14
MY147949A (en) 2013-02-15
PT1863787E (pt) 2011-07-29
CN101180290B (zh) 2012-12-12
SI1863787T1 (sl) 2011-10-28
KR101382733B1 (ko) 2014-04-14
TWI402262B (zh) 2013-07-21
RU2007138875A (ru) 2009-04-27
PL1863787T3 (pl) 2011-10-31
ES2365747T3 (es) 2011-10-10
MX2007011670A (es) 2007-11-15
CY1111767T1 (el) 2015-10-07
RU2412179C2 (ru) 2011-02-20
NO20075299L (no) 2007-12-27
IL186148A0 (en) 2008-01-20
AU2006226018B2 (en) 2012-07-12
ATE510831T1 (de) 2011-06-15
EP1863787B1 (en) 2011-05-25
KR20080003360A (ko) 2008-01-07
WO2006100631A1 (en) 2006-09-28
CA2602474C (en) 2014-06-10
DK1863787T3 (da) 2011-08-01
IL186148A (en) 2012-05-31
EP1863787A1 (en) 2007-12-12
US20100204198A1 (en) 2010-08-12
US8039644B2 (en) 2011-10-18
US7723378B2 (en) 2010-05-25
AU2006226018A1 (en) 2006-09-28
AR053452A1 (es) 2007-05-09
CA2602474A1 (en) 2006-09-28
HRP20110613T1 (hr) 2011-09-30
NO340192B1 (no) 2017-03-20
NZ562562A (en) 2010-11-26
BRPI0609515A2 (pt) 2010-04-13
JP5047941B2 (ja) 2012-10-10

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