ZA200708601B - 39-desmethoxy derivatives of rapamycin - Google Patents
39-desmethoxy derivatives of rapamycinInfo
- Publication number
- ZA200708601B ZA200708601B ZA200708601A ZA200708601A ZA200708601B ZA 200708601 B ZA200708601 B ZA 200708601B ZA 200708601 A ZA200708601 A ZA 200708601A ZA 200708601 A ZA200708601 A ZA 200708601A ZA 200708601 B ZA200708601 B ZA 200708601B
- Authority
- ZA
- South Africa
- Prior art keywords
- rapamycin
- desmethoxy derivatives
- desmethoxy
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0504994.5A GB0504994D0 (en) | 2005-03-11 | 2005-03-11 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200708601B true ZA200708601B (en) | 2009-02-25 |
Family
ID=34508873
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200708601A ZA200708601B (en) | 2005-03-11 | 2006-03-10 | 39-desmethoxy derivatives of rapamycin |
Country Status (24)
Country | Link |
---|---|
US (2) | US7648996B2 (ko) |
EP (1) | EP1856129B8 (ko) |
JP (1) | JP5422788B2 (ko) |
KR (1) | KR20070113282A (ko) |
CN (2) | CN104211715A (ko) |
AU (1) | AU2006221786B2 (ko) |
BR (1) | BRPI0607441A2 (ko) |
CA (1) | CA2600640C (ko) |
CR (1) | CR9434A (ko) |
DK (1) | DK1856129T3 (ko) |
ES (1) | ES2527530T3 (ko) |
GB (1) | GB0504994D0 (ko) |
HR (1) | HRP20150012T1 (ko) |
IL (1) | IL185688A0 (ko) |
MX (1) | MX2007011131A (ko) |
NI (1) | NI200700230A (ko) |
NO (1) | NO20074594L (ko) |
NZ (1) | NZ561607A (ko) |
PL (1) | PL1856129T3 (ko) |
PT (1) | PT1856129E (ko) |
RS (1) | RS53778B1 (ko) |
RU (1) | RU2391346C2 (ko) |
WO (1) | WO2006095185A1 (ko) |
ZA (1) | ZA200708601B (ko) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2862538B1 (fr) * | 2003-11-21 | 2006-03-03 | Galderma Res & Dev | Utilisation de l'idrocilamide pour la preparation d'une composition pharmaceutique pour le traitement de la rosacee |
CN102886045A (zh) | 2005-02-03 | 2013-01-23 | 综合医院公司 | 治疗吉非替尼耐药性癌症的方法 |
KR20070116868A (ko) * | 2005-03-11 | 2007-12-11 | 바이오티카 테크놀로지 리미티드 | 39데스메톡시라파마이신 및 그 유사체의 의학적 용도 |
NZ561647A (en) * | 2005-03-11 | 2011-01-28 | Biotica Tech Ltd | Medical uses of 39-desmethoxyrapamycin and analogues thereof |
AR057854A1 (es) * | 2005-11-04 | 2007-12-19 | Wyeth Corp | Combinaciones antineoplasicas con inhibidor de mtor, herceptina y/o hki-272 (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi) anilino]-3-ciano-7-etoxi-6-quinolinil}-4-(dimetilamino)-2-butenamida |
AU2013204788B2 (en) * | 2005-11-04 | 2016-12-08 | Wyeth Llc | Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272 |
AU2016259316B2 (en) * | 2005-11-04 | 2018-09-06 | Wyeth Llc | Antineoplastic combinations with mTOR inhibitor, herceptin, and/or HKI-272 |
EP1962839A4 (en) | 2005-11-14 | 2010-08-25 | Ariad Pharma Inc | ADMINISTRATION OF A MNTOR INHIBITOR FOR THE TREATMENT OF PATIENTS WITH CANCER |
GB0609963D0 (en) | 2006-05-19 | 2006-06-28 | Biotica Tech Ltd | Novel compounds |
TW200845960A (en) * | 2007-04-05 | 2008-12-01 | Wyeth Corp | Wortmannin-rapalog conjugate and uses thereof |
CA2678415A1 (en) * | 2007-04-05 | 2008-10-16 | Wyeth | Wortmannin-rapamycin conjugate and uses thereof |
US20080287675A1 (en) * | 2007-05-18 | 2008-11-20 | Abbott Laboratories | Cascade system |
US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
EP2915532B1 (en) | 2008-06-17 | 2016-10-19 | Wyeth LLC | Antineoplastic combinations containing hki-272 and vinorelbine |
JP5681108B2 (ja) | 2008-08-04 | 2015-03-04 | ワイス・エルエルシー | 4−アニリノ−3−シアノキノリンとカペシタビンの抗新生物薬の組合せ |
US20120064143A1 (en) | 2008-11-11 | 2012-03-15 | The Board Of Regents Of The University Of Texas System | Inhibition of mammalian target of rapamycin |
RU2011139363A (ru) | 2009-04-06 | 2013-05-20 | ВАЙЕТ ЭлЭлСи | Схема лечения рака молочной железы с использованием нератиниба |
EP2480557A2 (en) | 2009-09-25 | 2012-08-01 | Cadila Healthcare Limited | Process for the preparation of rapamycin derivatives |
KR20120115237A (ko) | 2009-10-30 | 2012-10-17 | 어리어드 파마슈티칼스, 인코포레이티드 | 암 치료 방법 및 조성물 |
US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
WO2015103447A1 (en) | 2013-12-31 | 2015-07-09 | Rapamycin Holdings, Llc | Oral rapamycin nanoparticle preparations and use |
EP2589383A1 (en) | 2011-11-06 | 2013-05-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin | FKBP subtype-specific rapamycin analogue for use in treatment of diseases |
GB201122305D0 (en) | 2011-12-23 | 2012-02-01 | Biotica Tech Ltd | Novel compound |
WO2014059295A1 (en) | 2012-10-12 | 2014-04-17 | The Board Of Regents Of The University Of Texas System | Use of mtor inhibitors to treat vascular cognitive impairment |
WO2014160328A1 (en) | 2013-03-13 | 2014-10-02 | The Board Of Regents Of The University Of Texas System | Mtor inhibitors for prevention of intestinal polyp growth |
US10682415B2 (en) | 2013-07-22 | 2020-06-16 | Wisconsin Alumni Research Foundation | Thermogel formulation for combination drug delivery |
WO2015013579A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Compositions to improve the therapeutic benefit of bisantrene |
US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
EP3131546B1 (en) | 2014-04-16 | 2022-02-16 | Rapamycin Holdings, Inc. | Oral rapamycin preparation for use in treating feline chronic gingivo- stomatitis (fcgs) |
JP6692798B2 (ja) | 2014-09-11 | 2020-05-13 | ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・カリフオルニア | mTORC1阻害剤 |
CN106153755B (zh) * | 2015-04-24 | 2020-02-14 | 山东新时代药业有限公司 | 2-(叔丁基二甲基硅烷基氧基)乙醇的分析检测方法 |
AU2016315653A1 (en) * | 2015-08-28 | 2018-03-15 | Buck Institute For Research On Aging | Rapamycin analogs showing improved mTORC1 specificity |
JP2020507632A (ja) * | 2017-02-10 | 2020-03-12 | マウント タム セラピューティクス, インコーポレイテッドMount Tam Therapeutics, Inc. | ラパマイシン類似体 |
WO2018213352A1 (en) | 2017-05-15 | 2018-11-22 | C.R. Bard, Inc. | Medical device with drug-eluting coating and intermediate layer |
UY37900A (es) * | 2017-09-26 | 2019-04-30 | Novartis Ag | Nuevos derivados de rapamicina |
SG11202012447YA (en) | 2018-06-15 | 2021-01-28 | Navitor Pharm Inc | Rapamycin analogs and uses thereof |
EP3880266A1 (en) | 2018-11-14 | 2021-09-22 | Lutonix, Inc. | Medical device with drug-eluting coating on modified device surface |
CN113939324A (zh) | 2019-04-08 | 2022-01-14 | 巴德外周血管股份有限公司 | 在经改性装置表面上具有药物洗脱涂层的医疗装置 |
CN110343639B (zh) * | 2019-07-23 | 2021-04-27 | 中国医药集团总公司四川抗菌素工业研究所 | 一株产15(s)-o-乙基雷帕霉素的链霉菌 |
IL293549A (en) | 2019-12-05 | 2022-08-01 | Anakuria Therapeutics Inc | Rapamycin analogs and their uses |
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ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
US3993749A (en) | 1974-04-12 | 1976-11-23 | Ayerst Mckenna And Harrison Ltd. | Rapamycin and process of preparation |
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US6015815A (en) | 1997-09-26 | 2000-01-18 | Abbott Laboratories | Tetrazole-containing rapamycin analogs with shortened half-lives |
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US6776796B2 (en) | 2000-05-12 | 2004-08-17 | Cordis Corportation | Antiinflammatory drug and delivery device |
CZ307637B6 (cs) * | 2001-02-19 | 2019-01-23 | Novartis Ag | 40-O-(2-Hydroxyethyl)rapamycin jako jediná účinná látka při léčení |
EP1478648B1 (en) * | 2002-02-01 | 2014-04-30 | ARIAD Pharmaceuticals, Inc. | Phosphorus-containing compounds and uses thereof |
EP1655372A3 (en) * | 2002-07-16 | 2008-01-16 | Biotica Technology Limited | Production of polyketides and other natural products |
US7160867B2 (en) | 2003-05-16 | 2007-01-09 | Isotechnika, Inc. | Rapamycin carbohydrate derivatives |
GB0417852D0 (en) | 2004-08-11 | 2004-09-15 | Biotica Tech Ltd | Production of polyketides and other natural products |
GB0504995D0 (en) * | 2005-03-11 | 2005-04-20 | Biotica Tech Ltd | Use of a compound |
KR20070116868A (ko) | 2005-03-11 | 2007-12-11 | 바이오티카 테크놀로지 리미티드 | 39데스메톡시라파마이신 및 그 유사체의 의학적 용도 |
-
2005
- 2005-03-11 GB GBGB0504994.5A patent/GB0504994D0/en not_active Ceased
-
2006
- 2006-03-10 JP JP2008500271A patent/JP5422788B2/ja not_active Expired - Fee Related
- 2006-03-10 DK DK06710063.6T patent/DK1856129T3/en active
- 2006-03-10 MX MX2007011131A patent/MX2007011131A/es active IP Right Grant
- 2006-03-10 WO PCT/GB2006/000853 patent/WO2006095185A1/en active Application Filing
- 2006-03-10 CN CN201410347137.4A patent/CN104211715A/zh active Pending
- 2006-03-10 AU AU2006221786A patent/AU2006221786B2/en not_active Ceased
- 2006-03-10 NZ NZ561607A patent/NZ561607A/en not_active IP Right Cessation
- 2006-03-10 ZA ZA200708601A patent/ZA200708601B/xx unknown
- 2006-03-10 KR KR1020077023040A patent/KR20070113282A/ko not_active Application Discontinuation
- 2006-03-10 CA CA2600640A patent/CA2600640C/en not_active Expired - Fee Related
- 2006-03-10 EP EP06710063.6A patent/EP1856129B8/en active Active
- 2006-03-10 US US11/908,250 patent/US7648996B2/en not_active Expired - Fee Related
- 2006-03-10 PT PT67100636T patent/PT1856129E/pt unknown
- 2006-03-10 PL PL06710063T patent/PL1856129T3/pl unknown
- 2006-03-10 CN CN200680016325.2A patent/CN101175760B/zh not_active Expired - Fee Related
- 2006-03-10 BR BRPI0607441-3A patent/BRPI0607441A2/pt not_active IP Right Cessation
- 2006-03-10 RU RU2007137668/04A patent/RU2391346C2/ru not_active IP Right Cessation
- 2006-03-10 ES ES06710063.6T patent/ES2527530T3/es active Active
- 2006-03-10 RS RS20150009A patent/RS53778B1/en unknown
-
2007
- 2007-09-03 IL IL185688A patent/IL185688A0/en unknown
- 2007-09-07 NI NI200700230A patent/NI200700230A/es unknown
- 2007-09-11 NO NO20074594A patent/NO20074594L/no not_active Application Discontinuation
- 2007-10-11 CR CR9434A patent/CR9434A/es not_active Application Discontinuation
-
2009
- 2009-12-03 US US12/630,251 patent/US8008318B2/en active Active
-
2015
- 2015-01-08 HR HRP20150012TT patent/HRP20150012T1/hr unknown
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