ZA200700368B - Retinal derivatives and methods for the use thereof for the treatment of visual disorders - Google Patents

Retinal derivatives and methods for the use thereof for the treatment of visual disorders

Info

Publication number
ZA200700368B
ZA200700368B ZA200700368A ZA200700368A ZA200700368B ZA 200700368 B ZA200700368 B ZA 200700368B ZA 200700368 A ZA200700368 A ZA 200700368A ZA 200700368 A ZA200700368 A ZA 200700368A ZA 200700368 B ZA200700368 B ZA 200700368B
Authority
ZA
South Africa
Prior art keywords
treatment
methods
visual disorders
retinal derivatives
retinal
Prior art date
Application number
ZA200700368A
Other languages
English (en)
Inventor
Palczewski Krzysztof
Batten Matthew
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of ZA200700368B publication Critical patent/ZA200700368B/xx

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225Polycarboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/12Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by esterified hydroxy groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/10Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by etherified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/14Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09Geometrical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Physiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA200700368A 2004-06-18 2005-06-20 Retinal derivatives and methods for the use thereof for the treatment of visual disorders ZA200700368B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58088904P 2004-06-18 2004-06-18

Publications (1)

Publication Number Publication Date
ZA200700368B true ZA200700368B (en) 2008-10-29

Family

ID=35782277

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200700368A ZA200700368B (en) 2004-06-18 2005-06-20 Retinal derivatives and methods for the use thereof for the treatment of visual disorders

Country Status (27)

Country Link
US (8) US7951841B2 (de)
EP (5) EP2397132B1 (de)
JP (2) JP5166026B2 (de)
KR (4) KR20140140616A (de)
CN (2) CN1988898B (de)
AU (1) AU2005257997B2 (de)
BR (1) BRPI0511396B1 (de)
CA (2) CA2571049C (de)
CY (2) CY1114873T1 (de)
DK (2) DK1765322T3 (de)
ES (4) ES2443194T3 (de)
HK (1) HK1098696A1 (de)
HR (1) HRP20140116T1 (de)
HU (1) HUE036596T2 (de)
IL (4) IL180078A (de)
IN (1) IN2012DN09335A (de)
LT (1) LT2397133T (de)
MX (2) MXPA06014750A (de)
NO (1) NO339969B1 (de)
NZ (2) NZ552080A (de)
PL (2) PL2397133T3 (de)
PT (2) PT1765322E (de)
RS (1) RS53178B (de)
RU (2) RU2408578C2 (de)
SI (2) SI2397133T1 (de)
WO (1) WO2006002097A2 (de)
ZA (1) ZA200700368B (de)

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Also Published As

Publication number Publication date
EP2397130A2 (de) 2011-12-21
ES2752924T3 (es) 2020-04-06
AU2005257997A1 (en) 2006-01-05
NO339969B1 (no) 2017-02-20
KR20070026817A (ko) 2007-03-08
HUE036596T2 (hu) 2018-07-30
KR101337321B1 (ko) 2013-12-06
KR20120062946A (ko) 2012-06-14
US9174936B2 (en) 2015-11-03
RU2010138410A (ru) 2012-03-27
ES2644984T3 (es) 2017-12-01
ES2443194T3 (es) 2014-02-18
US20110288170A1 (en) 2011-11-24
IL180078A (en) 2014-01-30
PT1765322E (pt) 2014-02-05
US9162978B2 (en) 2015-10-20
JP2008503496A (ja) 2008-02-07
BRPI0511396B1 (pt) 2021-07-27
CN102976937A (zh) 2013-03-20
CA2931917A1 (en) 2006-01-05
AU2005257997B2 (en) 2012-04-05
US7951841B2 (en) 2011-05-31
KR20130079669A (ko) 2013-07-10
IL230242A (en) 2015-10-29
EP2397131A2 (de) 2011-12-21
PT2397133T (pt) 2017-10-23
NO20070330L (no) 2007-03-15
HRP20140116T1 (hr) 2014-03-28
EP2397133A2 (de) 2011-12-21
KR101323122B1 (ko) 2013-10-30
CN102976937B (zh) 2016-12-21
EP2397130B1 (de) 2019-04-03
EP1765322B1 (de) 2013-11-06
RS53178B (en) 2014-06-30
US20130072559A1 (en) 2013-03-21
WO2006002097A3 (en) 2006-05-04
PL1765322T3 (pl) 2014-04-30
US9388130B2 (en) 2016-07-12
CA2571049C (en) 2016-08-09
EP2397130A3 (de) 2012-10-31
DK1765322T3 (da) 2014-02-10
EP1765322A4 (de) 2008-09-17
IN2012DN09335A (de) 2015-08-21
RU2554003C2 (ru) 2015-06-20
EP2397132A2 (de) 2011-12-21
RU2007101735A (ru) 2008-07-27
EP2397131B1 (de) 2019-09-11
DK2397133T3 (en) 2017-10-30
EP2397132B1 (de) 2017-07-26
EP1765322A2 (de) 2007-03-28
US20170014368A1 (en) 2017-01-19
CY1119480T1 (el) 2018-03-07
US9169204B2 (en) 2015-10-27
RU2408578C2 (ru) 2011-01-10
BRPI0511396A (pt) 2007-12-04
EP2397131A3 (de) 2012-10-31
IL180078A0 (en) 2007-05-15
IL230241A (en) 2015-06-30
US9403765B2 (en) 2016-08-02
EP2397132A3 (de) 2012-07-11
JP5596749B2 (ja) 2014-09-24
CN1988898A (zh) 2007-06-27
MX359668B (es) 2018-10-05
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US20190167626A1 (en) 2019-06-06
US20130079403A1 (en) 2013-03-28
US20130072556A1 (en) 2013-03-21
US10117845B2 (en) 2018-11-06
SI2397133T1 (sl) 2017-12-29
CN1988898B (zh) 2012-12-26
US20080221208A1 (en) 2008-09-11
US20130072560A1 (en) 2013-03-21
JP5166026B2 (ja) 2013-03-21
KR101490145B1 (ko) 2015-02-05
ES2644981T3 (es) 2017-12-01
WO2006002097A2 (en) 2006-01-05
IL222347A (en) 2017-08-31
MXPA06014750A (es) 2007-03-21
KR20140140616A (ko) 2014-12-09
EP2397133A3 (de) 2012-07-11
NZ552080A (en) 2011-03-31
CA2571049A1 (en) 2006-01-05
SI1765322T1 (sl) 2014-03-31
LT2397133T (lt) 2018-01-10
HK1098696A1 (en) 2007-07-27
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EP2397133B1 (de) 2017-07-26
JP2012229234A (ja) 2012-11-22

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