ZA200610503B - Novel method for producting tiotropium salts - Google Patents

Novel method for producting tiotropium salts

Info

Publication number
ZA200610503B
ZA200610503B ZA200610503A ZA200610503A ZA200610503B ZA 200610503 B ZA200610503 B ZA 200610503B ZA 200610503 A ZA200610503 A ZA 200610503A ZA 200610503 A ZA200610503 A ZA 200610503A ZA 200610503 B ZA200610503 B ZA 200610503B
Authority
ZA
South Africa
Prior art keywords
producting
novel method
tiotropium salts
tiotropium
salts
Prior art date
Application number
ZA200610503A
Other languages
English (en)
Inventor
Belzer Werner
Hamm Rainer
Hofmann Monika
Lock Ralf
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35745545&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200610503(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of ZA200610503B publication Critical patent/ZA200610503B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
ZA200610503A 2004-08-26 2006-12-14 Novel method for producting tiotropium salts ZA200610503B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004041253A DE102004041253A1 (de) 2004-08-26 2004-08-26 Neues Verfahren zur Herstellung von Tiotropiumsalzen

Publications (1)

Publication Number Publication Date
ZA200610503B true ZA200610503B (en) 2008-09-25

Family

ID=35745545

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200610503A ZA200610503B (en) 2004-08-26 2006-12-14 Novel method for producting tiotropium salts

Country Status (16)

Country Link
US (2) US7491824B2 (ko)
EP (1) EP1794158A2 (ko)
JP (1) JP5173421B2 (ko)
KR (1) KR101274455B1 (ko)
CN (1) CN100532382C (ko)
AR (1) AR050714A1 (ko)
AU (1) AU2005276432B2 (ko)
BR (1) BRPI0514643A (ko)
CA (1) CA2573373C (ko)
DE (1) DE102004041253A1 (ko)
IL (3) IL181522A (ko)
NZ (1) NZ553840A (ko)
RU (1) RU2384575C2 (ko)
TW (2) TWI387595B (ko)
WO (1) WO2006021559A2 (ko)
ZA (1) ZA200610503B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101648950B (zh) * 2003-11-03 2014-05-07 贝林格尔.英格海姆国际有限公司 噻托铵盐、其医药制剂及其用途
AU2004285683C1 (en) * 2003-11-03 2011-09-08 Boehringer Ingelheim International Gmbh Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same
RU2417224C2 (ru) * 2005-05-02 2011-04-27 Бёрингер Ингельхайм Интернациональ Гмбх Новые кристаллические формы тиотропийбромида
NZ564697A (en) * 2005-06-15 2010-04-30 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
US20080051582A1 (en) * 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
US9707375B2 (en) 2011-03-14 2017-07-18 Rochester Medical Corporation, a subsidiary of C. R. Bard, Inc. Catheter grip and method
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
US8680297B2 (en) 2011-10-06 2014-03-25 Drug Process Licensing Assoc., LLC Manufacturing process for tiotropium bromide
CZ304808B6 (cs) 2012-03-16 2014-11-05 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu a jeho nová forma
CZ305012B6 (cs) 2012-03-30 2015-03-25 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu
CN105324106A (zh) 2013-04-01 2016-02-10 普马特里克斯营业公司 噻托铵干粉
WO2019129801A1 (en) 2017-12-28 2019-07-04 Linnea S.A. Process for the purification of methyl-2,2-dithienylglycolate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ220791A (en) * 1986-06-27 1990-08-28 Marion Laboratories Inc 1-phenyl-7-aminohept-5-yn-2-one derivatives
DE4108393A1 (de) * 1991-03-15 1992-09-17 Boehringer Ingelheim Kg Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
US5554120A (en) * 1994-07-25 1996-09-10 Advanced Cardiovascular Systems, Inc. Polymer blends for use in making medical devices including catheters and balloons for dilatation catheters
DE10200943A1 (de) 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern

Also Published As

Publication number Publication date
BRPI0514643A (pt) 2008-06-17
TW201231466A (en) 2012-08-01
US20090118511A1 (en) 2009-05-07
TWI387595B (zh) 2013-03-01
AR050714A1 (es) 2006-11-15
IL213720A (en) 2012-03-29
RU2007110951A (ru) 2008-10-10
RU2384575C2 (ru) 2010-03-20
KR20070046196A (ko) 2007-05-02
US7491824B2 (en) 2009-02-17
AU2005276432A1 (en) 2006-03-02
DE102004041253A1 (de) 2006-03-02
IL213717A0 (en) 2011-07-31
IL213720A0 (en) 2011-07-31
EP1794158A2 (de) 2007-06-13
US8008495B2 (en) 2011-08-30
JP5173421B2 (ja) 2013-04-03
WO2006021559A3 (de) 2006-08-17
IL181522A0 (en) 2007-07-04
AU2005276432B2 (en) 2011-11-10
WO2006021559A2 (de) 2006-03-02
CN101001855A (zh) 2007-07-18
NZ553840A (en) 2010-06-25
IL181522A (en) 2011-08-31
TW200617006A (en) 2006-06-01
CA2573373C (en) 2014-05-06
JP2008510774A (ja) 2008-04-10
CA2573373A1 (en) 2006-03-02
TWI429646B (zh) 2014-03-11
WO2006021559A8 (de) 2006-11-16
CN100532382C (zh) 2009-08-26
US20060047120A1 (en) 2006-03-02
KR101274455B1 (ko) 2013-06-18

Similar Documents

Publication Publication Date Title
ZA200610503B (en) Novel method for producting tiotropium salts
IL183091A0 (en) Method for preparing n-phenylpyrazole-1-carboxyamides
IL188600A0 (en) Method for preparing esomeprazole
IL180247A0 (en) Method for producing 4-
HK1103722A1 (en) Production method
IL188989A0 (en) Novel method for producing tiotropium salts
IL177233A0 (en) Method for producing polyisobutenylphenols
PL1831223T3 (pl) Sposób wytwarzania L-biopteryny
EP1790633A4 (en) PROCESS FOR THE PREPARATION OF 2-HYDROXY-4-METHYLTHIOBUTAN ACID
GB2456999B (en) Method for preparing 2-deoxy-L-ribose
EP1767563A4 (en) PROCESS FOR PREPARING POLYETHERES
PL1682541T3 (pl) Sposób wytwarzania soli tiotropium
GB0416952D0 (en) Scale making method
IL178069A0 (en) Process for preparing n-aryl-piperazine derivatives
GB0416694D0 (en) Process for preparing microcrystals
IL208214A0 (en) Methods for making 4-tetrazolyl-4-phenylpiperidine compounds
EP1878737A4 (en) METHOD OF SYNTHESIZING INDAZOLE-3-YLMETHYLPHOSPHONIUM SALT
EP1976858A4 (en) PROCESS FOR THE PREPARATION OF 4-DEMETHYLDAUNORUBICIN
IL183804A0 (en) Process for preparing substituted 2-alkoxycarbonyl-3-aminothiophenes
EP1760061A4 (en) PROCESS FOR THE PRODUCTION OF ETHERN
PL366494A1 (en) Method for obtaining 5-nitroguaiacol
IL190943A0 (en) Method for producing 2-(4-methyl-2-phenylpiperazin-1-yl)pyridine-3-methanol
ZA200500148B (en) Method for nano-sizing
PL372042A1 (pl) Sposób otrzymywania 3-chloropropyloorganosilanów
PL370755A1 (pl) Sposób otrzymywania dibutyrylochityny