ZA200610405B - Compounds and methods for inhibiting the interaction of BCL proteins with binding partners - Google Patents

Compounds and methods for inhibiting the interaction of BCL proteins with binding partners Download PDF

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Publication number
ZA200610405B
ZA200610405B ZA200610405A ZA200610405A ZA200610405B ZA 200610405 B ZA200610405 B ZA 200610405B ZA 200610405 A ZA200610405 A ZA 200610405A ZA 200610405 A ZA200610405 A ZA 200610405A ZA 200610405 B ZA200610405 B ZA 200610405B
Authority
ZA
South Africa
Prior art keywords
compound
alkyl
aryl
occurrence
ring
Prior art date
Application number
ZA200610405A
Other languages
English (en)
Inventor
Alfredo C Castro
Michael A Foley
Michael J Grogan
Brian T Hopkins
David A Mann
Dennis J Underwood
Zhang Linping
Deng Wei
Christian C Fritz
Hafeez Nafeeza
Nii O Koney
Lisa A Marcaurelle
Andrew A Wylie
Kristopher M Depew
Evangelinos Asimina T Georges
Edward B Holson
Liu Tao
Daniel A Snyder
Yu Lin-Chen
Original Assignee
Infinity Pharmaceticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infinity Pharmaceticals Inc filed Critical Infinity Pharmaceticals Inc
Publication of ZA200610405B publication Critical patent/ZA200610405B/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA200610405A 2004-06-17 2006-12-12 Compounds and methods for inhibiting the interaction of BCL proteins with binding partners ZA200610405B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58061604P 2004-06-17 2004-06-17
US65930105P 2005-03-07 2005-03-07

Publications (1)

Publication Number Publication Date
ZA200610405B true ZA200610405B (en) 2008-03-26

Family

ID=35335774

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200610405A ZA200610405B (en) 2004-06-17 2006-12-12 Compounds and methods for inhibiting the interaction of BCL proteins with binding partners

Country Status (22)

Country Link
US (1) US7851637B2 (ru)
EP (1) EP1768966B1 (ru)
JP (1) JP5064213B2 (ru)
KR (1) KR101195351B1 (ru)
CN (1) CN101006065B (ru)
AT (1) ATE548359T1 (ru)
AU (1) AU2005265131B2 (ru)
BR (1) BRPI0511070A (ru)
CA (1) CA2570780C (ru)
EC (1) ECSP067099A (ru)
ES (1) ES2382383T3 (ru)
HK (1) HK1105963A1 (ru)
IL (1) IL179904A (ru)
MA (1) MA28702B1 (ru)
MX (1) MXPA06014754A (ru)
NO (1) NO20070324L (ru)
NZ (1) NZ552183A (ru)
PL (1) PL1768966T3 (ru)
PT (1) PT1768966E (ru)
RU (1) RU2416606C2 (ru)
WO (1) WO2006009869A1 (ru)
ZA (1) ZA200610405B (ru)

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RU2416606C2 (ru) 2004-06-17 2011-04-20 Инфинити Дискавери, Инк. Соединения и способы для ингибирования взаимодействия bcl белков с компонентами по связыванию
US7842815B2 (en) * 2004-06-17 2010-11-30 Infinity Pharmaceuticals, Inc. Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
US8624027B2 (en) * 2005-05-12 2014-01-07 Abbvie Inc. Combination therapy for treating cancer and diagnostic assays for use therein
TWI403320B (zh) 2005-12-16 2013-08-01 Infinity Discovery Inc 用於抑制bcl蛋白和結合夥伴間之交互作用的化合物及方法
TWI389895B (zh) * 2006-08-21 2013-03-21 Infinity Discovery Inc 抑制bcl蛋白質與結合夥伴間之交互作用的化合物及方法
EP1897956A1 (en) * 2006-09-06 2008-03-12 Lonza AG Process for preparation of optically active amines by optical resolution of racemic amines employing a bacterial omega-transaminase
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US20110086834A1 (en) * 2008-06-26 2011-04-14 Amgen Inc. Alkynyl alcohols as kinase inhibitors
JP2012500263A (ja) * 2008-08-21 2012-01-05 アルヴィン ファーマシューティカルズ インコーポレーティッド タンパク質の経口投与のための製剤
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UA108193C2 (uk) * 2008-12-04 2015-04-10 Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань
EP2376480B1 (en) * 2008-12-05 2016-06-01 AbbVie Inc. Sulfonamide derivatives as bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US8563735B2 (en) 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
US8586754B2 (en) 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
KR101920202B1 (ko) * 2009-05-26 2018-11-21 애브비 아일랜드 언리미티드 컴퍼니 암,면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제
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AU2015211021B2 (en) 2014-01-28 2020-07-02 Buck Institute For Research On Aging Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
WO2015160975A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
WO2017096301A1 (en) * 2015-12-04 2017-06-08 Denali Therapeutics Inc. Isoxazolidine derived inhibitors of receptor interacting protein kinase 1 (ripk 1)
CA3018932C (en) 2016-03-28 2021-10-26 Presage Biosciences, Inc. Pharmaceutical combinations for the treatment of cancer
WO2021233948A1 (en) 2020-05-19 2021-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Method to treat a pathogen lung infection
US20230270816A1 (en) 2020-07-06 2023-08-31 INSERM (Institute National de la Santé et de la Recherche Médicale) Combination of antineoplastic antibiotics and bcl-2 inhibitors for the treatment of npm-1-driven acute myeloid leukemia (aml)

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Also Published As

Publication number Publication date
EP1768966B1 (en) 2012-03-07
PT1768966E (pt) 2012-05-23
CA2570780C (en) 2013-12-03
IL179904A (en) 2011-11-30
CA2570780A1 (en) 2006-01-26
EP1768966A1 (en) 2007-04-04
AU2005265131A1 (en) 2006-01-26
NO20070324L (no) 2007-03-19
ECSP067099A (es) 2007-04-26
JP2008503489A (ja) 2008-02-07
PL1768966T3 (pl) 2012-08-31
ATE548359T1 (de) 2012-03-15
KR20070046068A (ko) 2007-05-02
RU2416606C2 (ru) 2011-04-20
AU2005265131B2 (en) 2012-02-23
US20060025460A1 (en) 2006-02-02
CN101006065A (zh) 2007-07-25
HK1105963A1 (en) 2008-02-29
US7851637B2 (en) 2010-12-14
IL179904A0 (en) 2007-05-15
RU2007101276A (ru) 2008-08-10
NZ552183A (en) 2009-10-30
MA28702B1 (fr) 2007-06-01
JP5064213B2 (ja) 2012-10-31
MXPA06014754A (es) 2007-06-22
CN101006065B (zh) 2012-07-11
KR101195351B1 (ko) 2012-10-29
BRPI0511070A (pt) 2007-11-27
WO2006009869A1 (en) 2006-01-26
ES2382383T3 (es) 2012-06-07

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