ZA200608808B - Tetrahydro-indazoile cannabinoid modulators - Google Patents
Tetrahydro-indazoile cannabinoid modulators Download PDFInfo
- Publication number
- ZA200608808B ZA200608808B ZA200608808A ZA200608808A ZA200608808B ZA 200608808 B ZA200608808 B ZA 200608808B ZA 200608808 A ZA200608808 A ZA 200608808A ZA 200608808 A ZA200608808 A ZA 200608808A ZA 200608808 B ZA200608808 B ZA 200608808B
- Authority
- ZA
- South Africa
- Prior art keywords
- hydroxy
- phenyl
- optionally substituted
- halogen
- aryl
- Prior art date
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- 229930003827 cannabinoid Natural products 0.000 title description 17
- 239000003557 cannabinoid Substances 0.000 title description 17
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 146
- 125000000217 alkyl group Chemical group 0.000 claims description 73
- 229910052736 halogen Inorganic materials 0.000 claims description 68
- 125000003545 alkoxy group Chemical group 0.000 claims description 67
- 150000002367 halogens Chemical class 0.000 claims description 67
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 58
- 125000003118 aryl group Chemical group 0.000 claims description 45
- -1 hydroxy-alkylene- Chemical group 0.000 claims description 41
- 150000001875 compounds Chemical class 0.000 claims description 40
- 125000002947 alkylene group Chemical group 0.000 claims description 34
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 33
- 125000000623 heterocyclic group Chemical group 0.000 claims description 28
- 229910052739 hydrogen Inorganic materials 0.000 claims description 26
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 25
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 25
- 239000001257 hydrogen Substances 0.000 claims description 22
- 229910052757 nitrogen Inorganic materials 0.000 claims description 22
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims description 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
- 125000004104 aryloxy group Chemical group 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
- 239000000556 agonist Substances 0.000 claims description 9
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- 108010073376 CB2 Cannabinoid Receptor Proteins 0.000 claims description 4
- 125000001118 alkylidene group Chemical group 0.000 claims description 4
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 claims description 4
- 230000001404 mediated effect Effects 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
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- 125000002541 furyl group Chemical group 0.000 claims description 3
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- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims description 2
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- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 142
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- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 description 5
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- QHMBSVQNZZTUGM-UHFFFAOYSA-N Trans-Cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-UHFFFAOYSA-N 0.000 description 3
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- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
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- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55589004P | 2004-03-24 | 2004-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200608808B true ZA200608808B (en) | 2008-06-25 |
Family
ID=34965110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200608808A ZA200608808B (en) | 2004-03-24 | 2006-10-23 | Tetrahydro-indazoile cannabinoid modulators |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7452997B2 (ja) |
| EP (1) | EP1735286B1 (ja) |
| JP (1) | JP4825792B2 (ja) |
| CN (1) | CN1956964B (ja) |
| AR (1) | AR048341A1 (ja) |
| AT (1) | ATE540027T1 (ja) |
| AU (1) | AU2005228868B2 (ja) |
| BR (1) | BRPI0509207A (ja) |
| CA (1) | CA2561305C (ja) |
| CR (1) | CR8701A (ja) |
| DK (1) | DK1735286T3 (ja) |
| EA (1) | EA010887B1 (ja) |
| EC (1) | ECSP066877A (ja) |
| ES (1) | ES2378071T3 (ja) |
| IL (1) | IL178290A0 (ja) |
| MX (1) | MXPA06011017A (ja) |
| NO (1) | NO20064810L (ja) |
| PL (1) | PL1735286T3 (ja) |
| PT (1) | PT1735286E (ja) |
| TW (1) | TW200602324A (ja) |
| WO (1) | WO2005095353A1 (ja) |
| ZA (1) | ZA200608808B (ja) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2875230A1 (fr) * | 2004-09-13 | 2006-03-17 | Sanofi Aventis Sa | Derives de pyrazole condense, leur preparation et leur application en therapeutique |
| US7888381B2 (en) | 2005-06-14 | 2011-02-15 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof |
| US7825151B2 (en) * | 2005-09-23 | 2010-11-02 | Janssen Pharmaceutica Nv | Hexahydro-cyclooctyl pyrazole cannabinoid modulators |
| WO2007038045A1 (en) * | 2005-09-23 | 2007-04-05 | Janssen Pharmaceutica, N.V. | Tetrahydro-indazolyl cannabinoid modulators |
| CN101312725B (zh) * | 2005-09-23 | 2012-01-11 | 詹森药业有限公司 | 六氢-环辛四烯并吡唑大麻素调节剂 |
| CN101312952B (zh) * | 2005-09-23 | 2012-12-26 | 詹森药业有限公司 | 四氢-环戊二烯并吡唑大麻素调节剂 |
| US8378117B2 (en) | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
| US8378096B2 (en) | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
| ES2375213T3 (es) * | 2005-09-23 | 2012-02-27 | Janssen Pharmaceutica Nv | Moduladores de cannabinoides de hexadhidro-cicloheptapirazol. |
| WO2007095513A1 (en) * | 2006-02-14 | 2007-08-23 | Janssen Pharmaceutica, Nv | Tetrahydr0-2h-indaz0le derivatives for use as cannabinoid modulators |
| US20070254911A1 (en) * | 2006-03-27 | 2007-11-01 | Mingde Xia | Tetrahydro-Pyrazolo[3,4-c]Pyridine Cannabinoid Modulators |
| US8012957B2 (en) | 2006-03-27 | 2011-09-06 | Janssen Pharmaceutica Nv | Tetrahydro-1H-1,2,6-triaza-azulene cannabinoid modulators |
| WO2008054508A2 (en) * | 2006-04-13 | 2008-05-08 | Alza Corporation | Stable nanosized amorphous drug |
| WO2008053341A2 (en) * | 2006-11-03 | 2008-05-08 | Glenmark Pharmaceuticals S.A. | Bridged bicyclic indazoles as cannabinoid receptor ligands |
| EP1935420A1 (en) * | 2006-12-21 | 2008-06-25 | Merck Sante | 2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors |
| JP2010522182A (ja) * | 2007-03-21 | 2010-07-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｃｂ２受容体介在疼痛を処置する方法 |
| CA2681381A1 (en) * | 2007-03-21 | 2008-09-25 | Janssen Pharmaceutica N.V. | Method for treating cb2 receptor mediated pain |
| UA100120C2 (en) | 2007-04-03 | 2012-11-26 | Анадис Фармасьютикалз, Инк. | 5,6-dihydro-1h-pyridin-2-one compounds |
| US8338623B2 (en) * | 2007-07-09 | 2012-12-25 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
| US7943653B2 (en) * | 2007-08-13 | 2011-05-17 | Janssen Pharmaceutica N.V. | Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators |
| EP2240443B1 (en) * | 2008-01-08 | 2013-11-20 | Purdue Pharma LP | Proline analogs as ligands for cannabinoid receptors for the treatment of pain |
| US20090215850A1 (en) * | 2008-02-27 | 2009-08-27 | Mingde Xia | Method for treating cb2 receptor mediated pain |
| JP5425911B2 (ja) * | 2008-09-25 | 2014-02-26 | エフ．ホフマン−ラ ロシュ アーゲー | 脂質異常症及び関連疾患に対するｆｘｒモジュレーターとしての２，３−置換インダゾール又は４，５，６，７−テトラヒドロ−インダゾール |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| US10435375B2 (en) | 2015-05-05 | 2019-10-08 | Northwestern University | CXCR4 chemokine receptor modulators |
| US9682940B2 (en) | 2015-08-25 | 2017-06-20 | Janssen Pharmaceutica Nv | Indazole derivatives useful as CB-1 inverse agonists |
| CN105367498B (zh) * | 2015-11-11 | 2019-05-17 | 中国农业大学 | 吡唑并环-3-甲酰胺类似物及其制备和应用 |
| CN106397218A (zh) * | 2016-09-04 | 2017-02-15 | 王际菊 | S‑α‑环己基苯甲胺 |
| US20210253562A1 (en) * | 2018-07-03 | 2021-08-19 | Janssen Pharmaceutica Nv | Acylsufonamide compounds useful as ep3 receptor antagonists |
| TWI768464B (zh) * | 2019-09-12 | 2022-06-21 | 大陸商四川海思科製藥有限公司 | 三環吡唑衍生物及其製備 |
| WO2021047581A1 (zh) * | 2019-09-12 | 2021-03-18 | 四川海思科制药有限公司 | 一种六氢化苯并吡唑衍生物及其制备 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1052111B (it) * | 1972-02-29 | 1981-06-20 | Acraf | Acidi i benzil i h indazol 3 carbossilici sostituiti e loro derivati |
| US3895025A (en) * | 1973-03-29 | 1975-07-15 | Du Pont | 2-Benzimidazolethiol preparation |
| EP0226624A1 (en) * | 1985-06-14 | 1987-07-01 | The Upjohn Company | Cyclopentapyrazole and tetrahydroindazole compounds |
| US4861777A (en) | 1987-09-11 | 1989-08-29 | Mitsubishi Kasei Corporation | Pyrazole derivative and insecticidal and miticidal composition containing the derivative as active ingredient |
| JPH06306053A (ja) * | 1993-01-29 | 1994-11-01 | Sagami Chem Res Center | ３−アゾールカルボン酸誘導体の製造方法及びその中間体 |
| US5532237A (en) * | 1995-02-15 | 1996-07-02 | Merck Frosst Canada, Inc. | Indole derivatives with affinity for the cannabinoid receptor |
| US6410533B1 (en) * | 2000-02-10 | 2002-06-25 | Genzyme Corporation | Antibacterial compounds |
| US6653304B2 (en) * | 2000-02-11 | 2003-11-25 | Bristol-Myers Squibb Co. | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases |
| JP2005510492A (ja) * | 2001-10-26 | 2005-04-21 | ユニバーシティ オブ コネチカット | 新規な種類の効力のあるカンナビミメティックリガンド |
| WO2003087037A1 (en) * | 2002-04-05 | 2003-10-23 | Merck & Co., Inc. | Substituted aryl amides |
| US7145012B2 (en) * | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
-
2005
- 2005-03-23 CN CN2005800160828A patent/CN1956964B/zh not_active Expired - Fee Related
- 2005-03-23 US US11/087,943 patent/US7452997B2/en not_active Expired - Fee Related
- 2005-03-23 JP JP2007505172A patent/JP4825792B2/ja not_active Expired - Fee Related
- 2005-03-23 BR BRPI0509207-8A patent/BRPI0509207A/pt not_active IP Right Cessation
- 2005-03-23 MX MXPA06011017A patent/MXPA06011017A/es unknown
- 2005-03-23 PL PL05732229T patent/PL1735286T3/pl unknown
- 2005-03-23 DK DK05732229.9T patent/DK1735286T3/da active
- 2005-03-23 CA CA2561305A patent/CA2561305C/en not_active Expired - Fee Related
- 2005-03-23 AT AT05732229T patent/ATE540027T1/de active
- 2005-03-23 WO PCT/US2005/009819 patent/WO2005095353A1/en active Application Filing
- 2005-03-23 PT PT05732229T patent/PT1735286E/pt unknown
- 2005-03-23 ES ES05732229T patent/ES2378071T3/es active Active
- 2005-03-23 TW TW094108873A patent/TW200602324A/zh unknown
- 2005-03-23 EA EA200601760A patent/EA010887B1/ru not_active IP Right Cessation
- 2005-03-23 EP EP05732229A patent/EP1735286B1/en active Active
- 2005-03-23 AU AU2005228868A patent/AU2005228868B2/en not_active Ceased
- 2005-03-28 AR ARP050101196A patent/AR048341A1/es not_active Application Discontinuation
-
2006
- 2006-09-22 EC EC2006006877A patent/ECSP066877A/es unknown
- 2006-09-25 IL IL178290A patent/IL178290A0/en unknown
- 2006-10-20 CR CR8701A patent/CR8701A/es unknown
- 2006-10-23 NO NO20064810A patent/NO20064810L/no not_active Application Discontinuation
- 2006-10-23 ZA ZA200608808A patent/ZA200608808B/en unknown
-
2008
- 2008-10-08 US US12/247,263 patent/US20090099143A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PL1735286T3 (pl) | 2012-06-29 |
| US20090099143A1 (en) | 2009-04-16 |
| ATE540027T1 (de) | 2012-01-15 |
| ES2378071T3 (es) | 2012-04-04 |
| CN1956964A (zh) | 2007-05-02 |
| US20050228034A1 (en) | 2005-10-13 |
| BRPI0509207A (pt) | 2007-08-28 |
| CA2561305A1 (en) | 2005-10-13 |
| IL178290A0 (en) | 2006-12-31 |
| EA010887B1 (ru) | 2008-12-30 |
| NO20064810L (no) | 2006-12-22 |
| MXPA06011017A (es) | 2007-03-21 |
| DK1735286T3 (da) | 2012-04-02 |
| TW200602324A (en) | 2006-01-16 |
| ECSP066877A (es) | 2006-11-24 |
| AR048341A1 (es) | 2006-04-19 |
| AU2005228868B2 (en) | 2012-02-09 |
| CA2561305C (en) | 2013-07-30 |
| CR8701A (es) | 2008-11-24 |
| JP2007530577A (ja) | 2007-11-01 |
| AU2005228868A1 (en) | 2005-10-13 |
| WO2005095353A1 (en) | 2005-10-13 |
| EP1735286A1 (en) | 2006-12-27 |
| JP4825792B2 (ja) | 2011-11-30 |
| US7452997B2 (en) | 2008-11-18 |
| PT1735286E (pt) | 2012-03-05 |
| EP1735286B1 (en) | 2012-01-04 |
| EA200601760A1 (ru) | 2007-02-27 |
| CN1956964B (zh) | 2011-06-15 |
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