ZA200608808B - Tetrahydro-indazoile cannabinoid modulators - Google Patents
Tetrahydro-indazoile cannabinoid modulators Download PDFInfo
- Publication number
- ZA200608808B ZA200608808B ZA200608808A ZA200608808A ZA200608808B ZA 200608808 B ZA200608808 B ZA 200608808B ZA 200608808 A ZA200608808 A ZA 200608808A ZA 200608808 A ZA200608808 A ZA 200608808A ZA 200608808 B ZA200608808 B ZA 200608808B
- Authority
- ZA
- South Africa
- Prior art keywords
- hydroxy
- phenyl
- optionally substituted
- halogen
- aryl
- Prior art date
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- 229930003827 cannabinoid Natural products 0.000 title description 17
- 239000003557 cannabinoid Substances 0.000 title description 17
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 146
- 125000000217 alkyl group Chemical group 0.000 claims description 73
- 229910052736 halogen Inorganic materials 0.000 claims description 68
- 125000003545 alkoxy group Chemical group 0.000 claims description 67
- 150000002367 halogens Chemical class 0.000 claims description 67
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 58
- 125000003118 aryl group Chemical group 0.000 claims description 45
- -1 hydroxy-alkylene- Chemical group 0.000 claims description 41
- 150000001875 compounds Chemical class 0.000 claims description 40
- 125000002947 alkylene group Chemical group 0.000 claims description 34
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 33
- 125000000623 heterocyclic group Chemical group 0.000 claims description 28
- 229910052739 hydrogen Inorganic materials 0.000 claims description 26
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 25
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 25
- 239000001257 hydrogen Substances 0.000 claims description 22
- 229910052757 nitrogen Inorganic materials 0.000 claims description 22
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims description 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
- 125000004104 aryloxy group Chemical group 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
- 239000000556 agonist Substances 0.000 claims description 9
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- 108010073376 CB2 Cannabinoid Receptor Proteins 0.000 claims description 4
- 125000001118 alkylidene group Chemical group 0.000 claims description 4
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 claims description 4
- 230000001404 mediated effect Effects 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
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- 125000002541 furyl group Chemical group 0.000 claims description 3
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- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims description 2
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- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 142
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- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 description 5
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- QHMBSVQNZZTUGM-UHFFFAOYSA-N Trans-Cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-UHFFFAOYSA-N 0.000 description 3
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- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
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- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55589004P | 2004-03-24 | 2004-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200608808B true ZA200608808B (en) | 2008-06-25 |
Family
ID=34965110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200608808A ZA200608808B (en) | 2004-03-24 | 2006-10-23 | Tetrahydro-indazoile cannabinoid modulators |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7452997B2 (es) |
| EP (1) | EP1735286B1 (es) |
| JP (1) | JP4825792B2 (es) |
| CN (1) | CN1956964B (es) |
| AR (1) | AR048341A1 (es) |
| AT (1) | ATE540027T1 (es) |
| AU (1) | AU2005228868B2 (es) |
| BR (1) | BRPI0509207A (es) |
| CA (1) | CA2561305C (es) |
| CR (1) | CR8701A (es) |
| DK (1) | DK1735286T3 (es) |
| EA (1) | EA010887B1 (es) |
| EC (1) | ECSP066877A (es) |
| ES (1) | ES2378071T3 (es) |
| IL (1) | IL178290A0 (es) |
| MX (1) | MXPA06011017A (es) |
| NO (1) | NO20064810L (es) |
| PL (1) | PL1735286T3 (es) |
| PT (1) | PT1735286E (es) |
| TW (1) | TW200602324A (es) |
| WO (1) | WO2005095353A1 (es) |
| ZA (1) | ZA200608808B (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2875230A1 (fr) * | 2004-09-13 | 2006-03-17 | Sanofi Aventis Sa | Derives de pyrazole condense, leur preparation et leur application en therapeutique |
| US7888381B2 (en) | 2005-06-14 | 2011-02-15 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof |
| US8378096B2 (en) | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
| PL1931335T3 (pl) * | 2005-09-23 | 2010-07-30 | Janssen Pharmaceutica Nv | Modulatory heksahydrocyklooktylopirazolokannabinoidowe |
| CA2623745A1 (en) * | 2005-09-23 | 2007-04-05 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
| US7825151B2 (en) * | 2005-09-23 | 2010-11-02 | Janssen Pharmaceutica Nv | Hexahydro-cyclooctyl pyrazole cannabinoid modulators |
| US8378117B2 (en) * | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
| CN101312724A (zh) * | 2005-09-23 | 2008-11-26 | 詹森药业有限公司 | 四氢-吲唑基大麻素调节剂 |
| CN101312952B (zh) | 2005-09-23 | 2012-12-26 | 詹森药业有限公司 | 四氢-环戊二烯并吡唑大麻素调节剂 |
| WO2007095513A1 (en) * | 2006-02-14 | 2007-08-23 | Janssen Pharmaceutica, Nv | Tetrahydr0-2h-indaz0le derivatives for use as cannabinoid modulators |
| US20070254911A1 (en) * | 2006-03-27 | 2007-11-01 | Mingde Xia | Tetrahydro-Pyrazolo[3,4-c]Pyridine Cannabinoid Modulators |
| WO2007112402A1 (en) * | 2006-03-27 | 2007-10-04 | Janssen Pharmaceutica N.V. | Tetrahydro-1h-1,2,6-triaza-azulene cannabinoid modulators |
| WO2008054508A2 (en) * | 2006-04-13 | 2008-05-08 | Alza Corporation | Stable nanosized amorphous drug |
| JP2010509201A (ja) * | 2006-11-03 | 2010-03-25 | グレンマーク・ファーマシューティカルズ・エスエー | 新規なカンナビノイド受容体リガンド、およびこれらを含む薬剤組成物、およびこれらの調製方法 |
| EP1935420A1 (en) * | 2006-12-21 | 2008-06-25 | Merck Sante | 2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors |
| CA2681384A1 (en) * | 2007-03-21 | 2008-09-25 | Janssen Pharmaceutica N.V. | Method for treating cb2 receptor mediated pain |
| EP2139326A4 (en) * | 2007-03-21 | 2011-06-15 | Janssen Pharmaceutica Nv | METHOD OF TREATING PAIN INDUCED BY A CB2 RECEPTOR |
| UA100120C2 (en) | 2007-04-03 | 2012-11-26 | Анадис Фармасьютикалз, Инк. | 5,6-dihydro-1h-pyridin-2-one compounds |
| US8338623B2 (en) * | 2007-07-09 | 2012-12-25 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
| US7943653B2 (en) * | 2007-08-13 | 2011-05-17 | Janssen Pharmaceutica N.V. | Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators |
| CA2794054C (en) * | 2008-01-08 | 2014-11-25 | Purdue Pharma L.P. | Proline analogs as ligands for cannabinoid receptors |
| US20090215850A1 (en) * | 2008-02-27 | 2009-08-27 | Mingde Xia | Method for treating cb2 receptor mediated pain |
| WO2010034649A1 (en) * | 2008-09-25 | 2010-04-01 | F. Hoffmann-La Roche Ag | 2,3-substituted indazole or 4,5,6,7-tetrahydro-indazoles as fxr modulators against dyslipidemia and related diseases |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| US10435375B2 (en) | 2015-05-05 | 2019-10-08 | Northwestern University | CXCR4 chemokine receptor modulators |
| WO2017034872A1 (en) * | 2015-08-25 | 2017-03-02 | Janssen Pharmaceutica Nv | Indazole derivatives useful as cb-1 inverse agonists |
| CN105367498B (zh) * | 2015-11-11 | 2019-05-17 | 中国农业大学 | 吡唑并环-3-甲酰胺类似物及其制备和应用 |
| CN106397218A (zh) * | 2016-09-04 | 2017-02-15 | 王际菊 | S‑α‑环己基苯甲胺 |
| WO2020008317A1 (en) * | 2018-07-03 | 2020-01-09 | Janssen Pharmaceutica Nv | Acylsufonamide compounds useful as ep3 receptor antagonists |
| TWI768465B (zh) * | 2019-09-12 | 2022-06-21 | 大陸商四川海思科製藥有限公司 | 四氫吲唑衍生物及其製備 |
| WO2021047583A1 (zh) * | 2019-09-12 | 2021-03-18 | 四川海思科制药有限公司 | 一种三环吡唑衍生物及其制备 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1052111B (it) * | 1972-02-29 | 1981-06-20 | Acraf | Acidi i benzil i h indazol 3 carbossilici sostituiti e loro derivati |
| US3895025A (en) * | 1973-03-29 | 1975-07-15 | Du Pont | 2-Benzimidazolethiol preparation |
| WO1986007357A2 (en) * | 1985-06-14 | 1986-12-18 | Upjohn Co | Cyclopentapyrazole and tetrahydroindazole compounds |
| US4861777A (en) * | 1987-09-11 | 1989-08-29 | Mitsubishi Kasei Corporation | Pyrazole derivative and insecticidal and miticidal composition containing the derivative as active ingredient |
| JPH06306053A (ja) * | 1993-01-29 | 1994-11-01 | Sagami Chem Res Center | ３−アゾールカルボン酸誘導体の製造方法及びその中間体 |
| US5532237A (en) * | 1995-02-15 | 1996-07-02 | Merck Frosst Canada, Inc. | Indole derivatives with affinity for the cannabinoid receptor |
| US6410533B1 (en) | 2000-02-10 | 2002-06-25 | Genzyme Corporation | Antibacterial compounds |
| JP2004502642A (ja) * | 2000-02-11 | 2004-01-29 | ブリストル−マイヤーズ スクイブ カンパニー | カンナビノイドレセプターモジュレーター、それらの製造方法、および呼吸系および非呼吸系疾患の処置のためのカンナビノイドレセプターモジュレーターの使用 |
| EP1448557A4 (en) * | 2001-10-26 | 2005-02-02 | Univ Connecticut | HETEROINDANE: A NEW CLASS OF HIGH-ACTIVITY CANNABIMIMETIC LIGANDS |
| CA2480856A1 (en) * | 2002-04-05 | 2003-10-23 | Merck & Co., Inc. | Substituted aryl amides |
| US7145012B2 (en) * | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
-
2005
- 2005-03-23 ES ES05732229T patent/ES2378071T3/es active Active
- 2005-03-23 US US11/087,943 patent/US7452997B2/en not_active Expired - Fee Related
- 2005-03-23 TW TW094108873A patent/TW200602324A/zh unknown
- 2005-03-23 CA CA2561305A patent/CA2561305C/en not_active Expired - Fee Related
- 2005-03-23 AU AU2005228868A patent/AU2005228868B2/en not_active Ceased
- 2005-03-23 CN CN2005800160828A patent/CN1956964B/zh not_active Expired - Fee Related
- 2005-03-23 EP EP05732229A patent/EP1735286B1/en active Active
- 2005-03-23 WO PCT/US2005/009819 patent/WO2005095353A1/en active Application Filing
- 2005-03-23 EA EA200601760A patent/EA010887B1/ru not_active IP Right Cessation
- 2005-03-23 PL PL05732229T patent/PL1735286T3/pl unknown
- 2005-03-23 MX MXPA06011017A patent/MXPA06011017A/es unknown
- 2005-03-23 DK DK05732229.9T patent/DK1735286T3/da active
- 2005-03-23 JP JP2007505172A patent/JP4825792B2/ja not_active Expired - Fee Related
- 2005-03-23 AT AT05732229T patent/ATE540027T1/de active
- 2005-03-23 BR BRPI0509207-8A patent/BRPI0509207A/pt not_active IP Right Cessation
- 2005-03-23 PT PT05732229T patent/PT1735286E/pt unknown
- 2005-03-28 AR ARP050101196A patent/AR048341A1/es not_active Application Discontinuation
-
2006
- 2006-09-22 EC EC2006006877A patent/ECSP066877A/es unknown
- 2006-09-25 IL IL178290A patent/IL178290A0/en unknown
- 2006-10-20 CR CR8701A patent/CR8701A/es unknown
- 2006-10-23 ZA ZA200608808A patent/ZA200608808B/en unknown
- 2006-10-23 NO NO20064810A patent/NO20064810L/no not_active Application Discontinuation
-
2008
- 2008-10-08 US US12/247,263 patent/US20090099143A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP066877A (es) | 2006-11-24 |
| CN1956964A (zh) | 2007-05-02 |
| EP1735286B1 (en) | 2012-01-04 |
| EA200601760A1 (ru) | 2007-02-27 |
| AR048341A1 (es) | 2006-04-19 |
| NO20064810L (no) | 2006-12-22 |
| MXPA06011017A (es) | 2007-03-21 |
| CA2561305C (en) | 2013-07-30 |
| US7452997B2 (en) | 2008-11-18 |
| BRPI0509207A (pt) | 2007-08-28 |
| CN1956964B (zh) | 2011-06-15 |
| AU2005228868A1 (en) | 2005-10-13 |
| CA2561305A1 (en) | 2005-10-13 |
| ES2378071T3 (es) | 2012-04-04 |
| WO2005095353A1 (en) | 2005-10-13 |
| US20050228034A1 (en) | 2005-10-13 |
| ATE540027T1 (de) | 2012-01-15 |
| TW200602324A (en) | 2006-01-16 |
| CR8701A (es) | 2008-11-24 |
| IL178290A0 (en) | 2006-12-31 |
| PT1735286E (pt) | 2012-03-05 |
| AU2005228868B2 (en) | 2012-02-09 |
| US20090099143A1 (en) | 2009-04-16 |
| EA010887B1 (ru) | 2008-12-30 |
| PL1735286T3 (pl) | 2012-06-29 |
| JP4825792B2 (ja) | 2011-11-30 |
| DK1735286T3 (da) | 2012-04-02 |
| JP2007530577A (ja) | 2007-11-01 |
| EP1735286A1 (en) | 2006-12-27 |
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