ZA200605550B - Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist - Google Patents

Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist

Info

Publication number
ZA200605550B
ZA200605550B ZA200605550A ZA200605550A ZA200605550B ZA 200605550 B ZA200605550 B ZA 200605550B ZA 200605550 A ZA200605550 A ZA 200605550A ZA 200605550 A ZA200605550 A ZA 200605550A ZA 200605550 B ZA200605550 B ZA 200605550B
Authority
ZA
South Africa
Prior art keywords
receptor antagonist
crystalline polymorph
thrombin receptor
bisulfate salt
bisulfate
Prior art date
Application number
ZA200605550A
Other languages
English (en)
Inventor
Tiruvettipuram K Thiruvengadam
Wu Wenxue
Wang Tao
John S Chiu
Bogdanowich-Knipp Susan
Pavlovsky Anastasia
William J Greenlee
Michael P Graziano
Kosoglou Teddy
Chintala Madhu
Chackalamannil Samuel
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34807453&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200605550(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of ZA200605550B publication Critical patent/ZA200605550B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
ZA200605550A 2004-01-09 2006-07-05 Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist ZA200605550B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/755,066 US7235567B2 (en) 2000-06-15 2004-01-09 Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist

Publications (1)

Publication Number Publication Date
ZA200605550B true ZA200605550B (en) 2007-12-27

Family

ID=34807453

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200605550A ZA200605550B (en) 2004-01-09 2006-07-05 Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist

Country Status (23)

Country Link
US (2) US7235567B2 (de)
EP (2) EP2277879B1 (de)
JP (2) JP4652342B2 (de)
KR (3) KR101039973B1 (de)
CN (2) CN1910176B (de)
AR (2) AR047088A1 (de)
AU (1) AU2005206489B2 (de)
BR (1) BRPI0506761A (de)
CA (1) CA2552786C (de)
CL (1) CL2010000436A1 (de)
EC (1) ECSP066688A (de)
ES (1) ES2622953T3 (de)
HK (1) HK1151285A1 (de)
IL (1) IL176726A (de)
MX (1) MXPA06007830A (de)
MY (1) MY139399A (de)
NO (1) NO20063583L (de)
NZ (1) NZ548156A (de)
PE (1) PE20050761A1 (de)
RU (1) RU2355689C9 (de)
TW (1) TWI295291B (de)
WO (1) WO2005070923A1 (de)
ZA (1) ZA200605550B (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US7488742B2 (en) * 2000-06-15 2009-02-10 Schering Corporation Thrombin receptor antagonists
US20020164322A1 (en) * 2001-01-25 2002-11-07 Alfred Schaufler Suspension comprising fibrinogen, thrombin and alcohol, a method for preparing such a suspension, a method for coating a carrier with such a suspension, a method of drying a coating of a carrier, and a coated collagen sponge
US20060063930A1 (en) * 2004-08-20 2006-03-23 Agoston Gregory E Compositions and methods comprising proteinase activated receptor antagonists
PT1853592E (pt) * 2005-01-14 2011-05-10 Schering Corp S?ntese de an?logos da himbacina
US7541471B2 (en) * 2005-01-14 2009-06-02 Schering Corporation Synthesis of himbacine analogs
WO2006076565A2 (en) * 2005-01-14 2006-07-20 Schering Corporation Preparation of chiral propargylic alcohol and ester intermediates of himbacine analogs
DK2206697T3 (da) * 2005-01-14 2012-02-13 Schering Corp Exo- og diastereo-selektive synteser af himbacinanaloger
MX2007008622A (es) * 2005-01-14 2007-09-11 Schering Corp Una sintesis exo-selectiva de analogos de himbacina.
US8101799B2 (en) 2005-07-21 2012-01-24 Ardea Biosciences Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
WO2007075808A2 (en) * 2005-12-20 2007-07-05 Schering Corporation Methods for preventing and/or treating a cell proliferative disorder
CN101384259A (zh) * 2005-12-22 2009-03-11 先灵公司 作为预防来自心肺外科手术的并发症的凝血酶受体拮抗剂
PE20080183A1 (es) * 2006-04-06 2008-03-10 Schering Corp Terapias de combinacion de tra
MX2009000150A (es) * 2006-06-30 2009-01-23 Schering Corp Formulaciones de dosis solida de un antagonista del receptor de trombina.
TWI367112B (en) 2006-06-30 2012-07-01 Schering Corp Immediate-release tablet formulations of a thrombin receptor antagonist
AR061727A1 (es) * 2006-06-30 2008-09-17 Schering Corp Sintesis de dietil [[ 5- ( 3-fluorofenil) -piridin -2il] metil] fosfonato
TWI343262B (en) * 2006-09-26 2011-06-11 Schering Corp Rapidly disintegrating lyophilized oral formulations of a thrombin receptor antagonist
JP2010513516A (ja) * 2006-12-22 2010-04-30 シェーリング コーポレイション 固形剤の湿式顆粒化処方物中の崩壊促進剤
CA2681597A1 (en) * 2007-03-23 2008-10-02 Schering Corporation Reduction of adverse events after percutaneous intervention by use of a thrombin receptor antagonist
US8227412B2 (en) * 2007-03-29 2012-07-24 Tsopanoglou Nikos E Bioactive parstatin peptides and methods of use
EP2591783A1 (de) 2007-04-13 2013-05-15 Millennium Pharmaceuticals, Inc. Gerinnungshemmende Kombinationstherapie mit einer Verbindung als Faktor-Xa-Hemmer
US20090022729A1 (en) * 2007-04-13 2009-01-22 Nigel Mackman Methods and compositions for treating cardiac dysfunctions
EP2586439A1 (de) 2007-05-02 2013-05-01 Portola Pharmaceuticals, Inc. Kombinationstherapie mit einer Verbindung als Thrombozyt-ADP-Rezeptor-Hemmer
UA99731C2 (ru) * 2007-07-30 2012-09-25 Ардеа Биосайенсис, Инк Кристаллические полиморфные формы n-(ариламино)сульфонамидов как ингибиторы мэк, композиция (варианты) и применение
MX2010001244A (es) * 2007-07-30 2010-08-31 Ardea Biosciences Inc Derivados de n-(arilamino) sulfonamidas que incluyen polimorfos como inhibidores de mek asi como composiciones, metodos de uso y de preparacion de los mismos.
KR20150096807A (ko) 2008-02-22 2015-08-25 마이크로 테라퓨틱스 인코포레이티드 혈류를 회복하는 방법 및 기구
US8044240B2 (en) 2008-03-06 2011-10-25 Ardea Biosciences Inc. Polymorphic form of N-(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and uses thereof
CL2009001214A1 (es) 2008-05-19 2010-12-31 Schering Corp Compuestos derivados de heterociclo, moduladores de serina proteasas composicion fa<rmacaeutica que los comprende; y su uso en el tratamiento de trastornos tromboembolicos
PL2438060T3 (pl) 2009-06-04 2014-03-31 Merck Sharp & Dohme Aktywny metabolit antagonisty receptora trombiny
US20120141586A1 (en) 2009-06-08 2012-06-07 Rubi Burlage Thrombin receptor antagonist and clopidogrel fixed dose tablet
WO2011017296A1 (en) 2009-08-04 2011-02-10 Schering Corporation 4, 5, 6-trisubstituted pyrimidine derivatives as factor ixa inhibitors
ES2532902T3 (es) 2010-04-16 2015-04-01 Sanofi Piridil-vinil-pirroles tricíclicos como inhibidores de PAR1
ES2527535T3 (es) 2010-04-16 2015-01-26 Sanofi Piridil-vinil-pirazolo-quinolinas como inhibidores de PAR1
EP2822557B1 (de) 2012-03-06 2017-08-23 Merck Sharp & Dohme Corp. Herstellung und verwendung bicyclischer himbacinderivate als par-rezeptor-antagonisten
EP3024550A4 (de) * 2013-07-22 2016-12-07 Merck Sharp & Dohme Co-kristall aus dem par-1-rezeptor-antagonisten vorapaxar und aspirin
WO2015026693A1 (en) 2013-08-22 2015-02-26 Merck Sharp & Dohme Corp. 7a-amide substituted-6,6-difluoro bicyclic himbacine derivatives
EP3035928B1 (de) 2013-08-22 2023-10-18 Merck Sharp & Dohme LLC 3 -pyridyl-substituierte 6,6-difluor-bicyclische himbacinderivate
US20160200715A1 (en) 2013-08-22 2016-07-14 Merck Sharp & Dohme Corp. Preparation and use of 7a-heterocycle substituted- 6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists
US9969724B2 (en) 2014-04-16 2018-05-15 Merck Sharp & Dohme Corp. Factor IXa inhibitors
CN106478608A (zh) * 2015-09-01 2017-03-08 博瑞生物医药（苏州）股份有限公司 沃拉帕沙的硫酸盐的结晶多晶型物
TR201601548A2 (tr) 2016-02-05 2018-03-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Vorapaksar ve metoprololün bi̇r farmasöti̇k kompozi̇syonu
WO2017134200A1 (en) 2016-02-05 2017-08-10 Sanovel Ilac Sanayi Ve Ticaret A.S. A novel pharmaceutical composition of vorapaxar and metoprolol
CN110407819B (zh) * 2019-08-02 2020-06-26 牡丹江医学院 一种作为预防外科手术并发症的凝血酶受体拮抗剂
CN110530924A (zh) * 2019-08-08 2019-12-03 西安交通大学 一种可施加电场的dsc电极系统
CN116133660A (zh) 2020-07-22 2023-05-16 詹森药业有限公司 可用作因子XIa抑制剂的化合物
US11845748B2 (en) 2021-03-18 2023-12-19 Janssen Pharmaceutica Nv Bicyclic pyridine N-oxide derivatives useful as a factor XIa inhibitors
US11814364B2 (en) 2021-03-18 2023-11-14 Janssen Pharmaceutica Nv Pyridine N-oxide derivatives useful as factor XIa inhibitors
US11919881B2 (en) 2021-03-18 2024-03-05 Janssen Pharmaceutica Nv Substituted pyridine N-oxide derivatives useful as a factor XIa inhibitors
US11897880B2 (en) 2021-04-30 2024-02-13 Janssen Pharmaceutica Nv 7,8-dihydrobenzo[e]pyrido[3,4-c]azocine-2,5(3H,6H)-dione derivatives useful as a factor XIa inhibitors
US11958856B2 (en) 2021-07-22 2024-04-16 Janssen Pharmaceutica Nv Substituted 1,2,3,8,9,9a-hexahydro-5H-pyrrolo[1,2-a]azepin-5-ones as factor XIa inhibitors

Family Cites Families (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2691974A (en) * 1952-05-20 1954-10-19 Erlo C Nelson Automatic arrow holder
US2743716A (en) * 1953-01-19 1956-05-01 Peter M Wendt Archery arrow retaining device
US2777435A (en) * 1953-09-28 1957-01-15 Wendell R Brooks Bow with automatic arrow holder
US2975780A (en) * 1958-11-17 1961-03-21 Joseph C Fisher Archer's bow
US3158145A (en) * 1962-03-06 1964-11-24 Raymond L Handy Bow arrow holder
US3342173A (en) * 1965-01-04 1967-09-19 Eugene L Ferguson Bow with magnetic retractable arrow rest
US3618586A (en) * 1969-11-03 1971-11-09 George C Current Arrow sight and bowstring tension control
JPS4812480Y1 (de) * 1970-09-14 1973-04-04
US3760788A (en) * 1971-09-03 1973-09-25 Remington Arms Co Inc Archery bow arrow rest
US3867920A (en) * 1971-11-22 1975-02-25 Kenneth M Westphal Bow drawing indicator
US3769956A (en) * 1972-01-13 1973-11-06 M Simo Arrow rest for archery bow
US4075674A (en) * 1972-12-18 1978-02-21 Texas Instruments Incorporated Expandable electronic protection system
US3788299A (en) * 1973-02-16 1974-01-29 Honeywell Inc Automatically releasable arrow holding device for a crossbow
US3890951A (en) * 1973-11-12 1975-06-24 Jennings Compound Bow Inc Adjustable arrow rest
US3865096A (en) * 1973-12-28 1975-02-11 Jr Fernando Troncoso Archery bow arrow rest
US4061107A (en) * 1976-11-11 1977-12-06 Smith Wilbur J Clicker for indicating position of arrow
US4071014A (en) * 1977-03-07 1978-01-31 Trotter George H Arrow positioning device
US4183346A (en) * 1977-11-03 1980-01-15 Troncoso Fernando V Jr Archery bow in combination with an adjustable draw check
US4236497A (en) * 1979-01-11 1980-12-02 Troncoso Jr Fernando V Archery bow with arrow rest
US4343286A (en) * 1979-04-06 1982-08-10 Thacker Bobby J Archery bow
US4318390A (en) * 1980-05-15 1982-03-09 Trotter George H Arrow retainer
US4287868A (en) * 1980-06-16 1981-09-08 Schiff Charles M Retracting arrow rest
US4454858A (en) * 1981-11-06 1984-06-19 Henry Thomas J Draw length indicator for hunting bow
US4407261A (en) * 1981-12-24 1983-10-04 Elliott Kenneth L Arrow lock
US4453528A (en) * 1982-09-27 1984-06-12 William Eckert Arrow rest
US4881515A (en) * 1983-04-05 1989-11-21 Simo Miroslav A Laterally adjustable replaceable arrow rest
US4898145A (en) * 1983-08-01 1990-02-06 Simo Miroslav A Arrow rest and holder
US4579101A (en) * 1984-03-16 1986-04-01 Bateman Iii Earle W Swinging arm arrow rest
US4577612A (en) * 1984-06-18 1986-03-25 John T. Zell Arrow holder
US4542732A (en) * 1984-07-02 1985-09-24 Troncoso Vincent F Compound archery bow assembly
US4632087A (en) * 1984-09-17 1986-12-30 Cline Darrell W Archery arrow support device
US4676220A (en) * 1985-02-19 1987-06-30 Pietraszek Mitchell E Arrow rest
US4685439A (en) * 1985-08-19 1987-08-11 Cosentino Jr Victor A Automatically-released arrow holder
US4693228A (en) * 1986-02-13 1987-09-15 Kidde Recreation Products, Inc. Crossbow trigger mechanism
US4741320A (en) * 1986-03-14 1988-05-03 Wiard Arthur R Archery training aid
US4703745A (en) * 1986-10-03 1987-11-03 Hammond David R Arrow retention attachment for bow
US4862867A (en) * 1987-02-02 1989-09-05 Schmidt John M Arrow retainer for archery
US4796598A (en) * 1987-03-06 1989-01-10 Jones Robert L Retractable arrow launch ramp with compound crossbow
US5107819A (en) * 1987-07-23 1992-04-28 Pugh Gregory E Arrow holding and loading device for archery bows
US4823762A (en) * 1987-07-23 1989-04-25 Pugh Gregory E Arrow holding and loading device for archery bows
US4865008A (en) * 1988-04-29 1989-09-12 Golden Key-Futura, Inc. Disappearing archery arrow guide
US5025773A (en) * 1988-09-26 1991-06-25 Kurt Hintze Archery arrow support
US5161515A (en) * 1989-01-31 1992-11-10 Hammonds David R Reversible archery arrow holder and arrow rest device
US4865007A (en) * 1989-03-03 1989-09-12 Saunders Archery Co. Fall-away arrow rest assembly
US5146908A (en) * 1990-03-21 1992-09-15 Browning Hold-back system for bowstring
US5009215A (en) * 1990-07-02 1991-04-23 Ludwig James E Arrow rest and holder apparatus
US5156138A (en) * 1990-09-19 1992-10-20 Roger Grover Apparatus for drawing, holding and releasing bowstring
US5161514A (en) * 1990-11-01 1992-11-10 Cary John W Arrow rest
US5243959A (en) * 1991-05-24 1993-09-14 Savage Systems, Inc. Archery apparatus and method
US5243957A (en) * 1991-11-20 1993-09-14 Savage Systems, Inc. Archery apparatus
IL106197A (en) 1992-07-30 1999-11-30 Cor Therapeutics Inc Agagonists for the rhombin receptors and pharmaceutical preparations containing them
US5341789A (en) * 1993-04-30 1994-08-30 John Paglia Arrow rest with integrated arrow holder
US5415154A (en) * 1993-10-12 1995-05-16 A Design, Inc. Dropaway arrow rest and overdraw assembly
US5394858A (en) * 1993-11-18 1995-03-07 David R. Laliberte Arrow safety positioning apparatus
US5413084A (en) * 1993-12-01 1995-05-09 Haggard; Alan Combined archery sight and arrow rest
US5462041A (en) * 1993-12-20 1995-10-31 Solecki; Dennis Adjustable arrow guide
US5490492A (en) * 1994-01-27 1996-02-13 Savage Systems, Inc. Retracting arrow rest for archery bow
US5503136A (en) * 1994-04-29 1996-04-02 Cavalier Equipment Company, Inc. Arrow rest with retracting arm
US5632263A (en) * 1994-05-03 1997-05-27 Sartain; John K. Automatic arrow positioning device
US5555875A (en) * 1994-10-13 1996-09-17 Martin Archery Inc. Handle riser for an archery bow
US5606961A (en) * 1994-10-20 1997-03-04 Basik; Ronald Arrow rest assembly
US5553597A (en) * 1994-12-29 1996-09-10 Sparks; Rodney L. Overdraw for a compound bow
US5603309A (en) * 1995-09-18 1997-02-18 Sheliga; Douglas J. Manually operated arrow holder and replacer
US5669146A (en) * 1996-02-27 1997-09-23 Kenneth Robertson Changeable insert peep sight
US5676121A (en) * 1996-08-08 1997-10-14 Bizier; Wayne T. Fork tamer
US5671723A (en) * 1997-01-03 1997-09-30 Jerry A. Goff Archery drawlock
US5722381A (en) * 1997-02-27 1998-03-03 New Archery Products Corp. Apparatus for adjustably mounting a pivotal arrow rest
US6063847A (en) 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
JP3449620B2 (ja) 1997-11-25 2003-09-22 シェーリング コーポレイション トロンビンレセプターアンタゴニスト
US6044832A (en) * 1998-08-10 2000-04-04 Piersons, Jr.; Donald W. Fall away arrow rest assembly
US6021769A (en) * 1998-11-30 2000-02-08 Troncoso; Freddie Archery bow arrow rest
US6202635B1 (en) * 1999-05-17 2001-03-20 Daniel L. Evans Arrow launcher apparatus
US6035842A (en) * 1999-06-10 2000-03-14 Bradley; Michael M. Arrow stabilizing mechanism for bow and arrow
US6630451B1 (en) 1999-06-29 2003-10-07 Orthomcneil Pharmaceutical, Inc. Benzimidazolone peptidometics as thrombin receptor antagonist
AU5895500A (en) 1999-06-29 2001-01-31 Cor Therapeutics, Inc. Novel indazole peptidomimetics as thrombin receptor antagonists
US6858577B1 (en) 1999-06-29 2005-02-22 Ortho-Mcneil Pharmaceutical, Inc. Indole peptidomimetics as thrombin receptor antagonists
US6082348A (en) * 1999-07-22 2000-07-04 Savage; Huey P. Arrow west
IL153308A0 (en) 2000-06-15 2003-07-06 Schering Corp Thrombin receptor antagonists
US20040192753A1 (en) 2000-06-15 2004-09-30 Samuel Chackalamannil Methods of use of thrombin receptor antagonists
WO2002071847A1 (en) 2001-03-08 2002-09-19 Emory University Treatment of neurodegenerative diseases and conditions using pari antagonists
US20040242627A1 (en) 2001-04-19 2004-12-02 Shuichi Suzuki 2-Iminoimidazole derivatives (1)
IL160918A0 (en) * 2001-10-18 2004-08-31 Schering Corp Himbacine analogues as thrombin receptor antagonists
US6595195B1 (en) * 2002-01-18 2003-07-22 Montana Black Gold Arrow rest device
US6681753B2 (en) * 2002-04-11 2004-01-27 Abbas Ben Afshari Shaft clamping arrow rest
KR101026929B1 (ko) 2002-04-16 2011-04-04 쉐링 코포레이션 트리사이클릭 트롬빈 수용체 길항제
US6782881B2 (en) * 2003-01-16 2004-08-31 New Archery Products Corp. Move-away arrow rest

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RU2006128779A (ru) 2008-02-20
EP1701953B1 (de) 2014-11-19
EP2277879B1 (de) 2017-03-08
WO2005070923A1 (en) 2005-08-04
EP2277879A1 (de) 2011-01-26
TWI295291B (en) 2008-04-01
BRPI0506761A (pt) 2007-05-22
NZ548156A (en) 2010-07-30
JP4652342B2 (ja) 2011-03-16
CN101899039B (zh) 2012-11-28
KR20080100497A (ko) 2008-11-18
US20070203193A1 (en) 2007-08-30
PE20050761A1 (es) 2005-10-18
US20040176418A1 (en) 2004-09-09
IL176726A (en) 2012-08-30
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CA2552786A1 (en) 2005-08-04
MXPA06007830A (es) 2006-09-01
AU2005206489B2 (en) 2011-09-01
AU2005206489A1 (en) 2005-08-04
CN1910176B (zh) 2010-06-23
RU2355689C2 (ru) 2009-05-20
CA2552786C (en) 2009-11-24
RU2355689C9 (ru) 2010-07-10
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ECSP066688A (es) 2006-10-31
IL176726A0 (en) 2006-10-31
HK1151285A1 (zh) 2012-01-27
KR20110039402A (ko) 2011-04-15
CN1910176A (zh) 2007-02-07
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AR098260A2 (es) 2016-05-18

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