ZA200605549B - Neutral endopeptidase (NEP) and human soluble endopeptidase (hSEP) inhibitors for prophylaxis and treatment of neurodegenerative disorders - Google Patents

Neutral endopeptidase (NEP) and human soluble endopeptidase (hSEP) inhibitors for prophylaxis and treatment of neurodegenerative disorders

Info

Publication number
ZA200605549B
ZA200605549B ZA200605549A ZA200605549A ZA200605549B ZA 200605549 B ZA200605549 B ZA 200605549B ZA 200605549 A ZA200605549 A ZA 200605549A ZA 200605549 A ZA200605549 A ZA 200605549A ZA 200605549 B ZA200605549 B ZA 200605549B
Authority
ZA
South Africa
Prior art keywords
endopeptidase
hsep
nep
prophylaxis
treatment
Prior art date
Application number
ZA200605549A
Other languages
English (en)
Inventor
Weske Michael
Ikonomidou Hrissanthi
Lechoslaw A Turski
Ziegler Dieter
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34796705&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200605549(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of ZA200605549B publication Critical patent/ZA200605549B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA200605549A 2004-01-12 2006-07-05 Neutral endopeptidase (NEP) and human soluble endopeptidase (hSEP) inhibitors for prophylaxis and treatment of neurodegenerative disorders ZA200605549B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53553804P 2004-01-12 2004-01-12
EP04100067 2004-01-12
PCT/EP2005/050075 WO2005067937A1 (en) 2004-01-12 2005-01-10 Neutral endopeptidase (nep) and human soluble endopeptidase (hsep) inhibitors for prophylaxis and treatment of neurodegenerative disorders

Publications (1)

Publication Number Publication Date
ZA200605549B true ZA200605549B (en) 2007-12-27

Family

ID=34796705

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200605549A ZA200605549B (en) 2004-01-12 2006-07-05 Neutral endopeptidase (NEP) and human soluble endopeptidase (hSEP) inhibitors for prophylaxis and treatment of neurodegenerative disorders

Country Status (22)

Country Link
EP (1) EP1706121B1 (ja)
JP (1) JP4951350B2 (ja)
KR (1) KR101219580B1 (ja)
CN (1) CN101076339B (ja)
AT (1) ATE406899T1 (ja)
AU (1) AU2005205067B2 (ja)
BR (1) BRPI0506750A (ja)
CA (1) CA2551789C (ja)
CY (1) CY1108588T1 (ja)
DE (1) DE602005009487D1 (ja)
DK (1) DK1706121T3 (ja)
ES (1) ES2313279T3 (ja)
HR (1) HRP20080611T3 (ja)
IL (1) IL176456A (ja)
NO (1) NO20063623L (ja)
PL (1) PL1706121T3 (ja)
PT (1) PT1706121E (ja)
RU (1) RU2362563C2 (ja)
SI (1) SI1706121T1 (ja)
UA (1) UA82008C2 (ja)
WO (1) WO2005067937A1 (ja)
ZA (1) ZA200605549B (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010207597A1 (en) * 2009-01-24 2011-08-18 Phytopharm Plc Treatment of neurotrophic factor mediated disorders
AR079059A1 (es) 2009-12-07 2011-12-21 Abbott Healthcare Products Bv Acido ((3s)-3-(((1-(((2r)-2-carboxi-4-(1-naftil) butil) ciclopentil)-carbonil) amino )-2-oxo-2,3,4,5-tetrahidro-1h-1-benzazepin-1-il) acetico cristalino, su preparacion y uso
CN106065006B (zh) * 2015-04-22 2020-06-05 深圳信立泰药业股份有限公司 一种中性内肽酶抑制剂盐晶型及其制备方法
PL424453A1 (pl) * 2018-01-31 2019-08-12 Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością Sposoby zmniejszania szkodliwego działania niedoboru perfuzji narządów miąższowych przez inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP)
PL424452A1 (pl) 2018-01-31 2019-08-12 Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) do profilaktyki i leczenia chorób oczu
CN110590695B (zh) * 2019-10-22 2023-03-21 南华大学 苯并氮杂环类化合物及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19510566A1 (de) * 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19750002A1 (de) * 1997-11-12 1999-05-20 Solvay Pharm Gmbh Phosphonsäure-substituierte Benzazepinon-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP1073674A1 (en) * 1998-04-23 2001-02-07 Novartis AG Thiol inhibitors of endothelin-converting enzyme
US20020013307A1 (en) * 2000-05-23 2002-01-31 Pablo Lapuerta Use of vasopeptidase inhibitors to treat or slow the progression of cognitive dysfunction and to treat and/or prevent dementia
US6505135B2 (en) * 2001-03-13 2003-01-07 Micro Motion, Inc. Initialization algorithm for drive control in a coriolis flowmeter
PL367093A1 (en) * 2001-05-18 2005-02-21 Solvay Pharmaceuticals Gmbh Use of compounds with combined nep/mp-inhibitory activity in the preparation of medicaments
CL2004000545A1 (es) * 2003-03-18 2005-01-28 Pharmacia Corp Sa Organizada B Uso de un antagonista de los receptores de aldosterona y un antagonista de receptores de endotelina para el tratamiento o profilaxis de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopatia y enfermedades cardiovascul

Also Published As

Publication number Publication date
JP4951350B2 (ja) 2012-06-13
AU2005205067B2 (en) 2009-10-22
PT1706121E (pt) 2008-12-04
AU2005205067A1 (en) 2005-07-28
DK1706121T3 (da) 2009-01-05
JP2007517834A (ja) 2007-07-05
HRP20080611T3 (en) 2008-12-31
SI1706121T1 (sl) 2009-02-28
ES2313279T3 (es) 2009-03-01
EP1706121A1 (en) 2006-10-04
IL176456A0 (en) 2006-10-05
KR20060123541A (ko) 2006-12-01
RU2006129288A (ru) 2008-02-20
WO2005067937A1 (en) 2005-07-28
CY1108588T1 (el) 2014-04-09
NO20063623L (no) 2006-10-12
EP1706121B1 (en) 2008-09-03
BRPI0506750A (pt) 2007-05-22
ATE406899T1 (de) 2008-09-15
CN101076339A (zh) 2007-11-21
PL1706121T3 (pl) 2009-02-27
CA2551789A1 (en) 2005-07-28
CA2551789C (en) 2011-05-03
KR101219580B1 (ko) 2013-01-08
CN101076339B (zh) 2011-02-09
IL176456A (en) 2010-03-28
DE602005009487D1 (de) 2008-10-16
RU2362563C2 (ru) 2009-07-27
UA82008C2 (uk) 2008-02-25

Similar Documents

Publication Publication Date Title
WO2006011050A3 (en) Pyridine derivatives
GEP20125565B (en) Lactam compounds and their pharmaceutical use
HRP20041132A2 (en) 7-aryl-3, 9-diazabicyclo (3.3.1) non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases
UA86614C2 (ru) Соединение, которое имеет активность ингибитора киназ, фармацевтическая композиция, которая включает указанное соединение, и их применение для приготовления лекарственного препарата
MY144992A (en) Substituted 1,2,3,4-tetrahydroisoquinoline derivatives.
SG179034A1 (en) 2 -aminodihydro [1, 3] thiazines as bace 2 inhibitors for the treatment of diabetes
WO2006099943A8 (de) Amid substituierte 8-n-benzimidazole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
TW200722081A (en) New therapeutic combinations for the treatment or prevention of depression
EP1725536B8 (en) Imidazoline derivatives having cb1-antagonistic activity
TW200621716A (en) Novel compounds
TW200611701A (en) Novel compounds
TW200514772A (en) Novel tetrahydropyridine derivatives
HRP20080611T3 (en) Neutral endopeptidase (nep) and human soluble endopeptidase (hsep) inhibitors for prophylaxis and treatment of neurodegenerative disorders
PL1682528T3 (pl) Pochodne benzo[b][1,4]dioksepiny
WO2005040171A8 (en) Pyrazolo and imidazo-pyrimidine derivatives
TW200637861A (en) Novel diazabicyclononene derivative
TW200621773A (en) Bicyclononene derivatives
GB0420831D0 (en) Novel compounds
MXPA05011498A (es) Derivados de 9-azabiciclo[3.3.1]non-6-eno con un heteroatomo en la posicion 3 como inhibidores de renina.
WO2005030209A8 (en) Pyridine derivatives and use thereof as urotensin ii antagonists
MXPA05011496A (es) Derivados de azabiciclononeno.
IL187001A0 (en) Preparation of (s)-4-fluromethyl-dihydro-furan -2-one
WO2007111983A8 (en) New therapeutic combinations for the treatment or prevention of psychotic disorders
TW200621774A (en) Bicyclononene derivatives
TW200634014A (en) Novel diazabicyclononene derivative