ZA200603419B - Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof - Google Patents
Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof Download PDFInfo
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- ZA200603419B ZA200603419B ZA200603419A ZA200603419A ZA200603419B ZA 200603419 B ZA200603419 B ZA 200603419B ZA 200603419 A ZA200603419 A ZA 200603419A ZA 200603419 A ZA200603419 A ZA 200603419A ZA 200603419 B ZA200603419 B ZA 200603419B
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- South Africa
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- compound according
- solvate
- hydrate
- acceptable salt
- pharmaceutically acceptable
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- 238000011282 treatment Methods 0.000 title claims description 22
- 238000000034 method Methods 0.000 title claims description 19
- 230000002503 metabolic effect Effects 0.000 title claims description 14
- 150000003536 tetrazoles Chemical class 0.000 title description 7
- 150000001875 compounds Chemical class 0.000 claims description 88
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 47
- 150000003839 salts Chemical class 0.000 claims description 34
- 239000012453 solvate Substances 0.000 claims description 33
- 125000000217 alkyl group Chemical group 0.000 claims description 32
- 229910052736 halogen Inorganic materials 0.000 claims description 27
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 27
- 125000001188 haloalkyl group Chemical group 0.000 claims description 22
- 125000003545 alkoxy group Chemical group 0.000 claims description 20
- 150000002367 halogens Chemical class 0.000 claims description 20
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- 125000003342 alkenyl group Chemical group 0.000 claims description 14
- 125000000304 alkynyl group Chemical group 0.000 claims description 14
- 125000001424 substituent group Chemical group 0.000 claims description 14
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- LTQYSJKGRPGMPO-UHFFFAOYSA-N 3-(2h-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole Chemical compound C1=2CCCC=2NN=C1C1=NN=NN1 LTQYSJKGRPGMPO-UHFFFAOYSA-N 0.000 claims 1
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- SWSJDJYGSQGAFF-UHFFFAOYSA-N 3-(2h-tetrazol-5-yl)-1,6-dihydrocyclopenta[c]pyrazole Chemical compound C1C=CC2=C1NN=C2C1=NN=NN1 SWSJDJYGSQGAFF-UHFFFAOYSA-N 0.000 claims 1
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- CXBPIKBDSFXEMF-UHFFFAOYSA-N 3-(2h-tetrazol-5-yl)-4,6-dihydro-1h-thieno[3,4-c]pyrazole Chemical compound C1SCC=2C1=NNC=2C1=NN=NN1 CXBPIKBDSFXEMF-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51623803P | 2003-10-31 | 2003-10-31 |
Publications (1)
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| ZA200603419B true ZA200603419B (en) | 2006-10-25 |
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| ZA200603419A ZA200603419B (en) | 2003-10-31 | 2006-04-28 | Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof |
| ZA200606203A ZA200606203B (en) | 2003-10-31 | 2006-07-26 | Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof |
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| ZA200606203A ZA200606203B (en) | 2003-10-31 | 2006-07-26 | Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof |
Country Status (38)
| Country | Link |
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| US (2) | US8637555B2 (fr) |
| EP (2) | EP1683794A1 (fr) |
| JP (2) | JP4533898B2 (fr) |
| KR (1) | KR100850591B1 (fr) |
| CN (1) | CN1867562B (fr) |
| AR (1) | AR046611A1 (fr) |
| AT (1) | ATE328880T1 (fr) |
| AU (1) | AU2004287861B2 (fr) |
| BR (1) | BRPI0415631A (fr) |
| CA (1) | CA2539985C (fr) |
| CO (1) | CO5690551A2 (fr) |
| CR (1) | CR8270A (fr) |
| CY (1) | CY1105479T1 (fr) |
| DE (1) | DE602004001134T2 (fr) |
| DK (1) | DK1599469T3 (fr) |
| EA (1) | EA011484B1 (fr) |
| EC (1) | ECSP066529A (fr) |
| ES (1) | ES2267077T3 (fr) |
| GE (1) | GEP20094801B (fr) |
| HK (1) | HK1076468A1 (fr) |
| HR (1) | HRP20060286T3 (fr) |
| IL (1) | IL174042A0 (fr) |
| IS (1) | IS2372B (fr) |
| MA (1) | MA28171A1 (fr) |
| MX (1) | MXPA06004556A (fr) |
| MY (1) | MY140410A (fr) |
| NO (1) | NO20062509L (fr) |
| NZ (1) | NZ546285A (fr) |
| PE (1) | PE20050483A1 (fr) |
| PL (1) | PL1599469T3 (fr) |
| PT (1) | PT1599469E (fr) |
| RS (1) | RS20060290A (fr) |
| SI (1) | SI1599469T1 (fr) |
| TN (1) | TNSN06150A1 (fr) |
| TW (1) | TWI258478B (fr) |
| UA (1) | UA86783C2 (fr) |
| WO (1) | WO2005044816A1 (fr) |
| ZA (2) | ZA200603419B (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20050483A1 (es) | 2003-10-31 | 2005-08-25 | Arena Pharm Inc | Derivados de tetrazol de formula (i), sus composiciones farmaceuticas y procesos para producir composiciones farmaceuticas |
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