DK1599469T3 - Tetrazolderivater og fremgangsmåder til behandling af metabolismerelaterede forstyrrelser dermed - Google Patents

Tetrazolderivater og fremgangsmåder til behandling af metabolismerelaterede forstyrrelser dermed

Info

Publication number
DK1599469T3
DK1599469T3 DK04818324T DK04818324T DK1599469T3 DK 1599469 T3 DK1599469 T3 DK 1599469T3 DK 04818324 T DK04818324 T DK 04818324T DK 04818324 T DK04818324 T DK 04818324T DK 1599469 T3 DK1599469 T3 DK 1599469T3
Authority
DK
Denmark
Prior art keywords
methods
related disorders
tetrazole derivatives
treating metabolism
metabolism
Prior art date
Application number
DK04818324T
Other languages
Danish (da)
English (en)
Inventor
Thomas Schrader
Philip J Skinner
Jae-Kyu Jung
Graeme Semple
Steven L Colletti
Tawfik Gharbaoui
Rui Liang
Subharekha Raghavan
Darby Schmidt
James R Tata
Jason E Imbriglio
Original Assignee
Arena Pharm Inc
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharm Inc, Merck & Co Inc filed Critical Arena Pharm Inc
Application granted granted Critical
Publication of DK1599469T3 publication Critical patent/DK1599469T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK04818324T 2003-10-31 2004-10-29 Tetrazolderivater og fremgangsmåder til behandling af metabolismerelaterede forstyrrelser dermed DK1599469T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51623803P 2003-10-31 2003-10-31

Publications (1)

Publication Number Publication Date
DK1599469T3 true DK1599469T3 (da) 2006-10-09

Family

ID=34572875

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04818324T DK1599469T3 (da) 2003-10-31 2004-10-29 Tetrazolderivater og fremgangsmåder til behandling af metabolismerelaterede forstyrrelser dermed

Country Status (38)

Country Link
US (2) US8637555B2 (fr)
EP (2) EP1683794A1 (fr)
JP (2) JP4533898B2 (fr)
KR (1) KR100850591B1 (fr)
CN (1) CN1867562B (fr)
AR (1) AR046611A1 (fr)
AT (1) ATE328880T1 (fr)
AU (1) AU2004287861B2 (fr)
BR (1) BRPI0415631A (fr)
CA (1) CA2539985C (fr)
CO (1) CO5690551A2 (fr)
CR (1) CR8270A (fr)
CY (1) CY1105479T1 (fr)
DE (1) DE602004001134T2 (fr)
DK (1) DK1599469T3 (fr)
EA (1) EA011484B1 (fr)
EC (1) ECSP066529A (fr)
ES (1) ES2267077T3 (fr)
GE (1) GEP20094801B (fr)
HK (1) HK1076468A1 (fr)
HR (1) HRP20060286T3 (fr)
IL (1) IL174042A0 (fr)
IS (1) IS2372B (fr)
MA (1) MA28171A1 (fr)
MX (1) MXPA06004556A (fr)
MY (1) MY140410A (fr)
NO (1) NO20062509L (fr)
NZ (1) NZ546285A (fr)
PE (1) PE20050483A1 (fr)
PL (1) PL1599469T3 (fr)
PT (1) PT1599469E (fr)
RS (1) RS20060290A (fr)
SI (1) SI1599469T1 (fr)
TN (1) TNSN06150A1 (fr)
TW (1) TWI258478B (fr)
UA (1) UA86783C2 (fr)
WO (1) WO2005044816A1 (fr)
ZA (2) ZA200603419B (fr)

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PE20050483A1 (es) 2003-10-31 2005-08-25 Arena Pharm Inc Derivados de tetrazol de formula (i), sus composiciones farmaceuticas y procesos para producir composiciones farmaceuticas
DE602004022864D1 (de) 2003-11-21 2009-10-08 Arena Pharm Inc 4-oxo-4,5-dihydro-furan-2-carbonsäure und derivate und verfahren zur behandlung von stoffwechselerkrankungen mit diesen verbindungen
WO2006026273A2 (fr) * 2004-08-25 2006-03-09 Merck & Co., Inc. Procede pour traiter l'atherosclerose, la dyslipidemie et les etats pathologiques associes
JP2008519080A (ja) * 2004-11-05 2008-06-05 アリーナ ファーマシューティカルズ, インコーポレイテッド ナイアシン受容体部分的アゴニストを含む、潮紅および脂質関連障害を処置するための組成物
PE20060949A1 (es) 2004-12-23 2006-10-11 Arena Pharm Inc Derivados fusionados de pirazol como agonistas del receptor de niacina
US8168799B2 (en) 2005-04-28 2012-05-01 Merck Sharpe & Dohme Ltd. Process for the preparation of tetrazolytetrahydrocyclopentapyrazoles
US8168649B2 (en) 2005-06-28 2012-05-01 Merk Sharp & Dohme Corp. Niacin receptor agonists, compositions containing such compounds and methods of treatment
DE102006021733A1 (de) * 2006-05-09 2007-11-22 Bayer Healthcare Ag 3-Tetrazolylindazole und 3-Tetrazolylpyrazolopyridine sowie ihre Verwendung
DE102006043443A1 (de) 2006-09-15 2008-03-27 Bayer Healthcare Ag Neue aza-bicyclische Verbindungen und ihre Verwendung
DE102008063992A1 (de) 2008-12-19 2010-09-02 Lerner, Zinoviy, Dipl.-Ing. Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
JP2015522080A (ja) 2012-07-11 2015-08-03 エルセリクス セラピューティクス インコーポレイテッド スタチン、ビグアナイド、およびさらなる薬剤を含む心血管代謝性リスクを減少させるための組成物
EP3760629A1 (fr) 2013-02-21 2021-01-06 Adverio Pharma GmbH Formes du {4,6-diamino-2-[1-(2-fluorobenzyl)-1h-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}méthylcarbamate de méthyle
WO2015012210A1 (fr) * 2013-07-23 2015-01-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 Composé cyclique hétérocondensé
CN103755637A (zh) * 2013-12-26 2014-04-30 平湖优康药物研发有限公司 一种医药中间体1,4,5,6-四氢-3-环戊并吡唑甲腈的合成工艺
CA3096145A1 (fr) * 2019-10-11 2021-04-11 Royal Bank Of Canada Systeme et methode d`apprentissage automatique utilisant des reseaux de plongements

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US5948786A (en) 1996-04-12 1999-09-07 Sumitomo Pharmaceuticals Company, Limited Piperidinylpyrimidine derivatives
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AU3275999A (en) 1998-03-10 1999-09-27 Ono Pharmaceutical Co. Ltd. Carboxylic acid derivatives and drugs containing the same as the active ingredient
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PE20050483A1 (es) 2003-10-31 2005-08-25 Arena Pharm Inc Derivados de tetrazol de formula (i), sus composiciones farmaceuticas y procesos para producir composiciones farmaceuticas
CA2556073C (fr) 2004-02-14 2012-01-10 Smithkline Beecham Corporation Composes
WO2006026273A2 (fr) 2004-08-25 2006-03-09 Merck & Co., Inc. Procede pour traiter l'atherosclerose, la dyslipidemie et les etats pathologiques associes
JP2008519080A (ja) 2004-11-05 2008-06-05 アリーナ ファーマシューティカルズ, インコーポレイテッド ナイアシン受容体部分的アゴニストを含む、潮紅および脂質関連障害を処置するための組成物
PE20060949A1 (es) 2004-12-23 2006-10-11 Arena Pharm Inc Derivados fusionados de pirazol como agonistas del receptor de niacina
US8168799B2 (en) 2005-04-28 2012-05-01 Merck Sharpe & Dohme Ltd. Process for the preparation of tetrazolytetrahydrocyclopentapyrazoles

Also Published As

Publication number Publication date
NO20062509L (no) 2006-06-26
AU2004287861A1 (en) 2005-05-19
ES2267077T3 (es) 2007-03-01
MA28171A1 (fr) 2006-09-01
MXPA06004556A (es) 2006-07-06
EA011484B1 (ru) 2009-04-28
TW200530221A (en) 2005-09-16
DE602004001134D1 (de) 2006-07-20
HRP20060286T3 (en) 2007-03-31
GEP20094801B (en) 2009-10-26
CN1867562A (zh) 2006-11-22
ATE328880T1 (de) 2006-06-15
JP4533898B2 (ja) 2010-09-01
PL1599469T3 (pl) 2006-10-31
US20060217562A1 (en) 2006-09-28
SI1599469T1 (sl) 2006-10-31
JP2007509181A (ja) 2007-04-12
AR046611A1 (es) 2005-12-14
TWI258478B (en) 2006-07-21
EP1599469A1 (fr) 2005-11-30
CO5690551A2 (es) 2006-10-31
EP1683794A1 (fr) 2006-07-26
CN1867562B (zh) 2011-07-13
BRPI0415631A (pt) 2006-12-12
DE602004001134T2 (de) 2007-04-19
HK1076468A1 (en) 2006-01-20
PE20050483A1 (es) 2005-08-25
UA86783C2 (ru) 2009-05-25
EA200600879A1 (ru) 2006-10-27
CA2539985C (fr) 2010-02-16
JP2010163448A (ja) 2010-07-29
IS2372B (is) 2008-06-15
ECSP066529A (es) 2006-10-10
NZ546285A (en) 2010-04-30
KR100850591B1 (ko) 2008-08-05
CY1105479T1 (el) 2010-07-28
CR8270A (es) 2006-10-06
AU2004287861B2 (en) 2008-08-14
PT1599469E (pt) 2006-10-31
EP1599469B1 (fr) 2006-06-07
ZA200603419B (en) 2006-10-25
IL174042A0 (en) 2006-08-01
WO2005044816A1 (fr) 2005-05-19
KR20060073974A (ko) 2006-06-29
CA2539985A1 (fr) 2005-05-19
IS8481A (is) 2006-05-24
RS20060290A (en) 2008-11-28
TNSN06150A1 (en) 2007-11-15
US20070072924A1 (en) 2007-03-29
ZA200606203B (en) 2007-04-25
MY140410A (en) 2009-12-31
US8637555B2 (en) 2014-01-28

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