ZA200603227B - Veterinary method for administering a vitamin E derivative and formulation - Google Patents
Veterinary method for administering a vitamin E derivative and formulation Download PDFInfo
- Publication number
- ZA200603227B ZA200603227B ZA200603227A ZA200603227A ZA200603227B ZA 200603227 B ZA200603227 B ZA 200603227B ZA 200603227 A ZA200603227 A ZA 200603227A ZA 200603227 A ZA200603227 A ZA 200603227A ZA 200603227 B ZA200603227 B ZA 200603227B
- Authority
- ZA
- South Africa
- Prior art keywords
- vitamin
- emulsifier
- derivative
- tac
- sorbitol
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 34
- 150000003712 vitamin E derivatives Chemical class 0.000 title claims description 26
- 238000009472 formulation Methods 0.000 title claims description 22
- 238000000034 method Methods 0.000 title claims description 21
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 296
- 239000003995 emulsifying agent Substances 0.000 claims description 176
- 229930003427 Vitamin E Natural products 0.000 claims description 149
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 149
- 239000011709 vitamin E Substances 0.000 claims description 149
- 229940046009 vitamin E Drugs 0.000 claims description 149
- 235000019165 vitamin E Nutrition 0.000 claims description 149
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 92
- 239000000377 silicon dioxide Substances 0.000 claims description 46
- 241001465754 Metazoa Species 0.000 claims description 35
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 21
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 14
- 239000000600 sorbitol Substances 0.000 claims description 14
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical group CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 12
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 12
- 150000002148 esters Chemical class 0.000 claims description 12
- 239000000194 fatty acid Substances 0.000 claims description 11
- 229930195729 fatty acid Natural products 0.000 claims description 11
- 150000004665 fatty acids Chemical class 0.000 claims description 11
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 10
- 229940042585 tocopherol acetate Drugs 0.000 claims description 9
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 8
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 229920006395 saturated elastomer Polymers 0.000 claims description 5
- -1 vitamin E ester Chemical class 0.000 claims description 5
- 150000002430 hydrocarbons Chemical group 0.000 claims description 4
- 229930195734 saturated hydrocarbon Natural products 0.000 claims description 4
- 229930195735 unsaturated hydrocarbon Natural products 0.000 claims description 4
- WERKSKAQRVDLDW-ANOHMWSOSA-N [(2s,3r,4r,5r)-2,3,4,5,6-pentahydroxyhexyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO WERKSKAQRVDLDW-ANOHMWSOSA-N 0.000 claims description 3
- 235000019728 animal nutrition Nutrition 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 230000002496 gastric effect Effects 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 235000016709 nutrition Nutrition 0.000 claims 1
- 230000035764 nutrition Effects 0.000 claims 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 42
- 239000001593 sorbitan monooleate Substances 0.000 description 41
- 235000011069 sorbitan monooleate Nutrition 0.000 description 41
- 229940035049 sorbitan monooleate Drugs 0.000 description 41
- 238000003556 assay Methods 0.000 description 26
- 230000007062 hydrolysis Effects 0.000 description 24
- 238000006460 hydrolysis reaction Methods 0.000 description 24
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 18
- 238000010521 absorption reaction Methods 0.000 description 18
- 210000004027 cell Anatomy 0.000 description 18
- 230000000694 effects Effects 0.000 description 18
- 239000001570 sorbitan monopalmitate Substances 0.000 description 18
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 18
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 18
- 210000004185 liver Anatomy 0.000 description 16
- 239000000243 solution Substances 0.000 description 16
- 239000003833 bile salt Substances 0.000 description 14
- 229940093761 bile salts Drugs 0.000 description 14
- 235000005911 diet Nutrition 0.000 description 14
- 238000011534 incubation Methods 0.000 description 14
- 241000287828 Gallus gallus Species 0.000 description 13
- 230000037213 diet Effects 0.000 description 12
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 12
- 238000011282 treatment Methods 0.000 description 11
- 102000000019 Sterol Esterase Human genes 0.000 description 9
- 108010055297 Sterol Esterase Proteins 0.000 description 9
- 210000002969 egg yolk Anatomy 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- 239000003921 oil Substances 0.000 description 9
- 235000019198 oils Nutrition 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 230000000875 corresponding effect Effects 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 229940088594 vitamin Drugs 0.000 description 8
- 229930003231 vitamin Natural products 0.000 description 8
- 235000013343 vitamin Nutrition 0.000 description 8
- 239000011782 vitamin Substances 0.000 description 8
- 238000004113 cell culture Methods 0.000 description 7
- 239000000693 micelle Substances 0.000 description 7
- 230000009469 supplementation Effects 0.000 description 7
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 6
- 108010019160 Pancreatin Proteins 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
- 235000013345 egg yolk Nutrition 0.000 description 6
- 238000004128 high performance liquid chromatography Methods 0.000 description 6
- 210000003205 muscle Anatomy 0.000 description 6
- 229940055695 pancreatin Drugs 0.000 description 6
- 229910052799 carbon Inorganic materials 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 4
- 241000282887 Suidae Species 0.000 description 4
- 240000008042 Zea mays Species 0.000 description 4
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 4
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 4
- 238000000540 analysis of variance Methods 0.000 description 4
- 235000014590 basal diet Nutrition 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 235000005822 corn Nutrition 0.000 description 4
- 235000013601 eggs Nutrition 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 235000012054 meals Nutrition 0.000 description 4
- 239000010452 phosphate Substances 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 4
- 230000036470 plasma concentration Effects 0.000 description 4
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 229940035044 sorbitan monolaurate Drugs 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- BMZIBHZDQPLVIS-UHFFFAOYSA-N 4-[2-(2-morpholin-4-ylethylselanyl)ethyl]morpholine Chemical compound C1COCCN1CC[Se]CCN1CCOCC1 BMZIBHZDQPLVIS-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
- 241000271566 Aves Species 0.000 description 3
- 241000209140 Triticum Species 0.000 description 3
- 235000021307 Triticum Nutrition 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 235000020940 control diet Nutrition 0.000 description 3
- 235000019621 digestibility Nutrition 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 244000144977 poultry Species 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 235000019750 Crude protein Nutrition 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 235000019482 Palm oil Nutrition 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 235000019764 Soybean Meal Nutrition 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000000378 dietary effect Effects 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- XUFQPHANEAPEMJ-UHFFFAOYSA-N famotidine Chemical compound NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1 XUFQPHANEAPEMJ-UHFFFAOYSA-N 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000006052 feed supplement Substances 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000007764 o/w emulsion Substances 0.000 description 2
- 239000002540 palm oil Substances 0.000 description 2
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229960000342 retinol acetate Drugs 0.000 description 2
- 235000019173 retinyl acetate Nutrition 0.000 description 2
- 239000011770 retinyl acetate Substances 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 239000004455 soybean meal Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 101000800807 Homo sapiens Tumor necrosis factor alpha-induced protein 8 Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102100030817 Liver carboxylesterase 1 Human genes 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 241000489861 Maximus Species 0.000 description 1
- RJECHNNFRHZQKU-UHFFFAOYSA-N Oelsaeurecholesterylester Natural products C12CCC3(C)C(C(C)CCCC(C)C)CCC3C2CC=C2C1(C)CCC(OC(=O)CCCCCCCC=CCCCCCCCC)C2 RJECHNNFRHZQKU-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 101150104938 Pigl gene Proteins 0.000 description 1
- 102100033649 Tumor necrosis factor alpha-induced protein 8 Human genes 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 238000013096 assay test Methods 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- RJECHNNFRHZQKU-RMUVNZEASA-N cholesteryl oleate Chemical compound C([C@@H]12)C[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@H]3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)C1 RJECHNNFRHZQKU-RMUVNZEASA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 238000007046 ethoxylation reaction Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 150000002646 long chain fatty acid esters Chemical group 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 150000002763 monocarboxylic acids Chemical class 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 238000003044 randomized block design Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 238000011272 standard treatment Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 235000015099 wheat brans Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Birds (AREA)
- Fodder In General (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- General Preparation And Processing Of Foods (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0312352A FR2861261B1 (fr) | 2003-10-22 | 2003-10-22 | Procede zootechnique pour l'administation d'un derive de vitamine e et formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200603227B true ZA200603227B (en) | 2008-02-27 |
Family
ID=34400704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200603227A ZA200603227B (en) | 2003-10-22 | 2006-04-21 | Veterinary method for administering a vitamin E derivative and formulation |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20060246117A1 (ru) |
| EP (1) | EP1677622A1 (ru) |
| JP (1) | JP2007508834A (ru) |
| KR (1) | KR20060097041A (ru) |
| CN (1) | CN100527983C (ru) |
| AU (1) | AU2004283508B2 (ru) |
| BR (1) | BRPI0415701A (ru) |
| CA (1) | CA2543505A1 (ru) |
| FR (1) | FR2861261B1 (ru) |
| MX (1) | MXPA06004342A (ru) |
| RU (1) | RU2375912C2 (ru) |
| UA (1) | UA92137C2 (ru) |
| WO (1) | WO2005039307A1 (ru) |
| ZA (1) | ZA200603227B (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA016809B1 (ru) * | 2010-04-07 | 2012-07-30 | Андрей Юрьевич Федорин | Кормовая добавка |
| WO2015191728A1 (en) * | 2014-06-11 | 2015-12-17 | Poviva Tea, Llc | Food and beverage compositions infused with lipophilic active agents and methods of use thereof |
| WO2020201586A1 (es) * | 2019-04-01 | 2020-10-08 | Lipidos Toledo S.A. | Suplemento para uso en la alimentacion animal |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3173838A (en) * | 1962-03-28 | 1965-03-16 | Eastman Kodak Co | Solid, vitamin e-active product and process for making it |
| US3253992A (en) * | 1962-09-27 | 1966-05-31 | Eastman Kodak Co | Water dispersible, anhydrous, water insoluble vitamin preparation and aqueous dispersions thereof |
| CH654206A5 (en) * | 1983-05-27 | 1986-02-14 | Locher & Co | Veterinary medical composition containing vitamin E and selenium, and process for its production |
| JP2676770B2 (ja) * | 1988-03-16 | 1997-11-17 | 大正製薬株式会社 | ビタミンｅの吸収改善製剤 |
| FR2631620B1 (fr) * | 1988-05-19 | 1990-07-27 | Rhone Poulenc Chimie | Nouvelle silice precipitee absorbante et composition a base de cette s ilice |
| JPH0249719A (ja) * | 1988-08-11 | 1990-02-20 | Dai Ichi Kogyo Seiyaku Co Ltd | 易水分散・可溶性能を有する油溶性ビタミン粉末 |
| SU1676572A1 (ru) * | 1989-06-13 | 1991-09-15 | Украинский Научно-Исследовательский Институт Физиологии И Биохимии Сельскохозяйственных Животных | Витаминный кормовой аппарат "Диспервит Е" дл птиц |
| JP3266656B2 (ja) * | 1992-08-18 | 2002-03-18 | 日清ファルマ株式会社 | ビタミン含浸粒状物およびその製造方法 |
| GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| JPH10215786A (ja) * | 1997-02-04 | 1998-08-18 | Nisshin Oil Mills Ltd:The | 酸化安定性の良い飼料 |
| GB9705813D0 (en) * | 1997-03-20 | 1997-05-07 | Smithkline Beecham Plc | Novel compositions |
| US20010051176A1 (en) * | 1997-08-06 | 2001-12-13 | Jean-Francois Viot | Composition comprising a liquid absorbed on a support based on precipitated silica |
| DE10104847B4 (de) * | 2000-06-09 | 2006-12-21 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Tocopherol-Konzentrat und Verfahren zu seiner Herstellung |
| GB0101198D0 (en) * | 2001-01-17 | 2001-02-28 | Scherer Technologies Inc R P | Ingestible compositions containing an odoriferous oil |
| FR2843894B1 (fr) * | 2002-08-30 | 2004-11-12 | Rhodia Chimie Sa | Compose forme de silice precipitee et de phosphate et son utilisation comme support de liquide a apport nutritionnel et comme agent antimottant a apport nutritionnel |
-
2003
- 2003-10-22 FR FR0312352A patent/FR2861261B1/fr not_active Expired - Fee Related
-
2004
- 2004-10-22 KR KR1020067009939A patent/KR20060097041A/ko not_active Application Discontinuation
- 2004-10-22 RU RU2006117305/13A patent/RU2375912C2/ru not_active IP Right Cessation
- 2004-10-22 EP EP04805282A patent/EP1677622A1/fr not_active Withdrawn
- 2004-10-22 UA UAA200605482A patent/UA92137C2/ru unknown
- 2004-10-22 JP JP2006536130A patent/JP2007508834A/ja active Pending
- 2004-10-22 CA CA002543505A patent/CA2543505A1/en not_active Abandoned
- 2004-10-22 CN CNB2004800313284A patent/CN100527983C/zh not_active Expired - Fee Related
- 2004-10-22 MX MXPA06004342A patent/MXPA06004342A/es active IP Right Grant
- 2004-10-22 BR BRPI0415701-0A patent/BRPI0415701A/pt not_active Application Discontinuation
- 2004-10-22 AU AU2004283508A patent/AU2004283508B2/en not_active Ceased
- 2004-10-22 WO PCT/FR2004/002719 patent/WO2005039307A1/fr active Application Filing
-
2006
- 2006-04-21 ZA ZA200603227A patent/ZA200603227B/en unknown
- 2006-04-24 US US11/408,985 patent/US20060246117A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004283508A2 (en) | 2005-05-06 |
| CA2543505A1 (en) | 2005-05-06 |
| MXPA06004342A (es) | 2006-06-27 |
| RU2006117305A (ru) | 2007-12-10 |
| UA92137C2 (ru) | 2010-10-11 |
| BRPI0415701A (pt) | 2006-12-19 |
| AU2004283508A1 (en) | 2005-05-06 |
| RU2375912C2 (ru) | 2009-12-20 |
| FR2861261B1 (fr) | 2007-11-16 |
| KR20060097041A (ko) | 2006-09-13 |
| CN100527983C (zh) | 2009-08-19 |
| WO2005039307A1 (fr) | 2005-05-06 |
| CN1870904A (zh) | 2006-11-29 |
| US20060246117A1 (en) | 2006-11-02 |
| AU2004283508B2 (en) | 2010-07-15 |
| JP2007508834A (ja) | 2007-04-12 |
| EP1677622A1 (fr) | 2006-07-12 |
| FR2861261A1 (fr) | 2005-04-29 |
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