ZA200602691B - Salts and polymorphs of a pyrrole-substituted indolinone compound - Google Patents
Salts and polymorphs of a pyrrole-substituted indolinone compound Download PDFInfo
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- ZA200602691B ZA200602691B ZA200602691A ZA200602691A ZA200602691B ZA 200602691 B ZA200602691 B ZA 200602691B ZA 200602691 A ZA200602691 A ZA 200602691A ZA 200602691 A ZA200602691 A ZA 200602691A ZA 200602691 B ZA200602691 B ZA 200602691B
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- South Africa
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- salt
- pyrrole
- fluoro
- carboxamide
- dihydro
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
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| US50810403P | 2003-10-02 | 2003-10-02 |
Publications (1)
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|---|---|
| ZA200602691B true ZA200602691B (en) | 2007-06-27 |
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| ZA200602691A ZA200602691B (en) | 2003-10-02 | 2006-03-31 | Salts and polymorphs of a pyrrole-substituted indolinone compound |
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|---|---|
| US (1) | US7247627B2 (es) |
| EP (1) | EP1670785B1 (es) |
| JP (1) | JP4933259B2 (es) |
| KR (2) | KR20080007520A (es) |
| CN (1) | CN100432072C (es) |
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| CA (1) | CA2540639C (es) |
| CY (1) | CY1110771T1 (es) |
| DE (1) | DE602004028028D1 (es) |
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| ES (1) | ES2348623T3 (es) |
| HK (1) | HK1093068A1 (es) |
| IL (1) | IL174414A (es) |
| MX (1) | MXPA06003661A (es) |
| NO (1) | NO20061246L (es) |
| NZ (1) | NZ546001A (es) |
| PL (1) | PL1670785T3 (es) |
| PT (1) | PT1670785E (es) |
| RU (1) | RU2319702C2 (es) |
| SI (1) | SI1670785T1 (es) |
| TW (1) | TW200524921A (es) |
| WO (1) | WO2005033098A1 (es) |
| ZA (1) | ZA200602691B (es) |
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| US20050182122A1 (en) * | 2003-11-20 | 2005-08-18 | Bello Carlo L. | Method of treating abnormal cell growth using indolinone compounds |
| BRPI0607579A2 (pt) * | 2005-03-23 | 2009-09-15 | Pfizer Prod Inc | uso de anticorpo anti-ctla4 e indolinona para a preparação de medicamentos para o tratamento de cáncer |
| CA2622870A1 (en) * | 2005-09-20 | 2007-03-29 | Pfizer Products Inc. | Dosage forms and methods of treatment using a tyrosine kinase inhibitor |
| TWI384986B (zh) * | 2007-01-17 | 2013-02-11 | Lg Life Sciences Ltd | 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物 |
| ES2682283T3 (es) * | 2007-04-04 | 2018-09-19 | Otsuka Chemical Co., Ltd. | Titanato de potasio, procedimiento de producción del mismo, materiales de fricción y composiciones de resina |
| KR20120015363A (ko) * | 2008-09-17 | 2012-02-21 | 노파르티스 아게 | Ｎ-［6-(시스-2,6-디메틸모르폴린-4-일)피리딘-3-일］-2-메틸-4'-(트리플루오로메톡시)［1,1'-비페닐］-3-카르복스아미드의 염 |
| WO2012042421A1 (en) | 2010-09-29 | 2012-04-05 | Pfizer Inc. | Method of treating abnormal cell growth |
| US9851313B2 (en) * | 2015-03-03 | 2017-12-26 | Panalytical B.V. | Quantitative X-ray analysis—ratio correction |
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| US5534522A (en) * | 1995-06-07 | 1996-07-09 | Warner-Lambert Company | (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent |
| DE19622489A1 (de) * | 1996-06-05 | 1997-12-11 | Hoechst Ag | Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters |
| UA73976C2 (uk) * | 2000-02-15 | 2005-10-17 | Суджен, Інк. | Заміщені піролом 2-індолінони, фармацевтична композиція, спосіб модуляції каталітичної активності протеїнкінази та спосіб лікування або профілактики захворювання, пов'язаного з протеїнкіназою |
| AR042586A1 (es) * | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| EP1419151B1 (en) * | 2001-08-15 | 2014-02-26 | Pharmacia & Upjohn Company LLC | Chrystals including a malic acid salt of n-[2-(diethylamino)ethyl] -5-[(5-fluoro-1,2-dihydro-2-oxo-3h-indole-3-ylidene)methyl] -2,4-dimethyl-1h-pyrrole-3-carboxamide, processes for its preparation and compositions thereof |
| YU67702A (sh) | 2001-09-28 | 2004-12-31 | Pfizer Products Inc. | Postupak za dobijanje alkansulfonil piridina |
| TWI259081B (en) * | 2001-10-26 | 2006-08-01 | Sugen Inc | Treatment of acute myeloid leukemia with indolinone compounds |
| JP2005528344A (ja) * | 2002-02-15 | 2005-09-22 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | インドリノン誘導体の製造法 |
| TW200418836A (en) * | 2002-09-10 | 2004-10-01 | Pharmacia Italia Spa | Formulations comprising an indolinone compound |
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2004
- 2004-09-20 PT PT04769435T patent/PT1670785E/pt unknown
- 2004-09-20 ES ES04769435T patent/ES2348623T3/es not_active Expired - Lifetime
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- 2004-09-20 JP JP2006530728A patent/JP4933259B2/ja not_active Expired - Fee Related
- 2004-09-20 AT AT04769435T patent/ATE473223T1/de active
- 2004-09-20 MX MXPA06003661A patent/MXPA06003661A/es active IP Right Grant
- 2004-09-20 NZ NZ546001A patent/NZ546001A/en unknown
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- 2004-09-20 RU RU2006110541/04A patent/RU2319702C2/ru not_active IP Right Cessation
- 2004-09-20 AU AU2004277464A patent/AU2004277464B2/en not_active Ceased
- 2004-09-20 CA CA2540639A patent/CA2540639C/en not_active Expired - Fee Related
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- 2004-09-20 SI SI200431486T patent/SI1670785T1/sl unknown
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- 2004-09-20 KR KR1020067006363A patent/KR20060058728A/ko active Search and Examination
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- 2006-03-20 IL IL174414A patent/IL174414A/en not_active IP Right Cessation
- 2006-03-31 ZA ZA200602691A patent/ZA200602691B/en unknown
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2010
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