ZA200601180B - Ammonium salts of ornithine derivatives for treating inflammatory diseases - Google Patents
Ammonium salts of ornithine derivatives for treating inflammatory diseases Download PDFInfo
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- ZA200601180B ZA200601180B ZA200601180A ZA200601180A ZA200601180B ZA 200601180 B ZA200601180 B ZA 200601180B ZA 200601180 A ZA200601180 A ZA 200601180A ZA 200601180 A ZA200601180 A ZA 200601180A ZA 200601180 B ZA200601180 B ZA 200601180B
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- ZA
- South Africa
- Prior art keywords
- mammal
- disease
- formula
- groups
- ammonium salts
- Prior art date
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- 208000027866 inflammatory disease Diseases 0.000 title claims description 19
- 150000003863 ammonium salts Chemical class 0.000 title abstract description 52
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical class NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 title abstract description 4
- 238000000034 method Methods 0.000 claims abstract description 27
- 150000001875 compounds Chemical class 0.000 claims description 46
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- 125000000217 alkyl group Chemical group 0.000 claims description 16
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- 239000001257 hydrogen Substances 0.000 claims description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
- 125000003342 alkenyl group Chemical group 0.000 claims description 6
- 125000003545 alkoxy group Chemical group 0.000 claims description 5
- 125000000623 heterocyclic group Chemical group 0.000 claims description 5
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- 238000004519 manufacturing process Methods 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 4
- 125000000304 alkynyl group Chemical group 0.000 claims description 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 4
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/634,811 US20050032807A1 (en) | 2003-08-06 | 2003-08-06 | Methods of treating inflammatory diseases with ammonium salts of ornitihine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200601180B true ZA200601180B (en) | 2007-04-25 |
Family
ID=34116103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200601180A ZA200601180B (en) | 2003-08-06 | 2006-02-23 | Ammonium salts of ornithine derivatives for treating inflammatory diseases |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20050032807A1 (ja) |
| EP (1) | EP1660093B1 (ja) |
| JP (1) | JP2007501227A (ja) |
| KR (1) | KR20070029101A (ja) |
| AT (1) | ATE401081T1 (ja) |
| AU (1) | AU2004264785A1 (ja) |
| CA (1) | CA2534558A1 (ja) |
| DE (1) | DE602004015116D1 (ja) |
| WO (1) | WO2005016350A1 (ja) |
| ZA (1) | ZA200601180B (ja) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040259878A1 (en) * | 2003-02-13 | 2004-12-23 | Jason Koutcher | Fluoromethotrexates and uses therefor |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4767761A (en) * | 1987-11-04 | 1988-08-30 | Dana-Farber Cancer Institute, Inc. | Ornithine derivatives and their use as methotrexate-resistant cell inhibitors |
| US4956461A (en) * | 1988-10-19 | 1990-09-11 | Dana Farber Cancer Institute, Inc. | Desamino-aminopterin and -methotrexate |
| CH680731A5 (ja) * | 1990-04-12 | 1992-10-30 | Sapec Fine Chemicals | |
| US5149688A (en) * | 1990-04-24 | 1992-09-22 | Cetus Corporation | Methods, compounds, and compositions for immunosuppression |
| JPH10310526A (ja) * | 1997-05-09 | 1998-11-24 | Iyaku Bunshi Sekkei Kenkyusho:Kk | ジヒドロ葉酸還元酵素の阻害剤 |
| US5912251A (en) * | 1998-01-17 | 1999-06-15 | Nair; Madhavan G. | Metabolically inert anti-inflammatory and anti-tumor antifolates |
| RU2222347C2 (ru) * | 1999-05-24 | 2004-01-27 | Санкио Компани Лимитед | Фармацевтические композиции, содержащие анти-fas-антитело |
| JP4270483B2 (ja) * | 2000-11-20 | 2009-06-03 | 第一三共株式会社 | カルバペネム系抗菌剤の製造方法 |
| KR20030086272A (ko) * | 2001-02-28 | 2003-11-07 | 멜라큐어 테라퓨틱스 에이비 | 디히드로폴레이트 리덕타아제 저해제로서의디아미노퀴나졸린 에스테르 |
| PE20030340A1 (es) * | 2001-08-28 | 2003-04-05 | Sankyo Co | Metodo para el tratamiento o prevencion de desgaste oseo |
| US6989386B2 (en) * | 2002-04-30 | 2006-01-24 | Dana-Farber Cancer Institute | Pharmaceutically active ornithine derivatives, ammonium salts thereof and methods of making same |
-
2003
- 2003-08-06 US US10/634,811 patent/US20050032807A1/en not_active Abandoned
-
2004
- 2004-02-23 DE DE602004015116T patent/DE602004015116D1/de not_active Expired - Fee Related
- 2004-02-23 CA CA002534558A patent/CA2534558A1/en not_active Abandoned
- 2004-02-23 AU AU2004264785A patent/AU2004264785A1/en not_active Abandoned
- 2004-02-23 EP EP04713788A patent/EP1660093B1/en not_active Expired - Lifetime
- 2004-02-23 KR KR1020067002558A patent/KR20070029101A/ko not_active Application Discontinuation
- 2004-02-23 JP JP2006522537A patent/JP2007501227A/ja active Pending
- 2004-02-23 WO PCT/US2004/005357 patent/WO2005016350A1/en active Application Filing
- 2004-02-23 AT AT04713788T patent/ATE401081T1/de not_active IP Right Cessation
-
2006
- 2006-02-23 ZA ZA200601180A patent/ZA200601180B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005016350A1 (en) | 2005-02-24 |
| DE602004015116D1 (de) | 2008-08-28 |
| ATE401081T1 (de) | 2008-08-15 |
| EP1660093B1 (en) | 2008-07-16 |
| CA2534558A1 (en) | 2005-02-24 |
| US20050032807A1 (en) | 2005-02-10 |
| JP2007501227A (ja) | 2007-01-25 |
| EP1660093A1 (en) | 2006-05-31 |
| AU2004264785A1 (en) | 2005-02-24 |
| KR20070029101A (ko) | 2007-03-13 |
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