ZA200600654B - Apparatus and method for bioelectric stimulation, healing acceleration, pain relief, or pathogen devitalization - Google Patents
Apparatus and method for bioelectric stimulation, healing acceleration, pain relief, or pathogen devitalization Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36021—External stimulators, e.g. with patch electrodes for treatment of pain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/025—Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36071—Pain
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cell Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Electrotherapy Devices (AREA)
- Finger-Pressure Massage (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48089003P | 2003-06-24 | 2003-06-24 |
Publications (1)
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|---|---|
| ZA200600654B true ZA200600654B (en) | 2007-01-31 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200600654A ZA200600654B (en) | 2003-06-24 | 2006-01-23 | Apparatus and method for bioelectric stimulation, healing acceleration, pain relief, or pathogen devitalization |
Country Status (17)
| Country | Link |
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| US (1) | US7117034B2 (ja) |
| EP (1) | EP1648553A4 (ja) |
| JP (1) | JP4980713B2 (ja) |
| KR (1) | KR101134242B1 (ja) |
| CN (1) | CN1842356B (ja) |
| AR (1) | AR044915A1 (ja) |
| AU (1) | AU2004253501B2 (ja) |
| BR (1) | BRPI0411817A (ja) |
| CA (2) | CA2876835C (ja) |
| CR (1) | CR8170A (ja) |
| EA (1) | EA200600093A1 (ja) |
| HK (1) | HK1096882A1 (ja) |
| IL (1) | IL172726A (ja) |
| MX (1) | MXPA05014141A (ja) |
| TW (1) | TWI306407B (ja) |
| WO (1) | WO2005002663A2 (ja) |
| ZA (1) | ZA200600654B (ja) |
Families Citing this family (402)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10835307B2 (en) | 2001-06-12 | 2020-11-17 | Ethicon Llc | Modular battery powered handheld surgical instrument containing elongated multi-layered shaft |
| WO2009021080A2 (en) * | 2007-08-06 | 2009-02-12 | Great Lakes Biosciences, Llc | Methods and apparatus for electrical stimulation of tissues using signals that minimize the effects of tissue impedance |
| WO2003095018A2 (en) | 2002-05-09 | 2003-11-20 | Daemen College | Electrical stimulation unit and waterbath system |
| US7801585B1 (en) | 2003-06-02 | 2010-09-21 | Newlife Sciences Llc | System for analyzing and treating abnormality of human and animal tissues |
| US7640052B2 (en) | 2004-05-28 | 2009-12-29 | Ippp, Llc | Method of integrated proton beam and therapeutic magnetic resonance therapy |
| US7744869B2 (en) * | 2003-08-20 | 2010-06-29 | Ebi, Llc | Methods of treatment using electromagnetic field stimulated mesenchymal stem cells |
| US8961385B2 (en) | 2003-12-05 | 2015-02-24 | Ivivi Health Sciences, Llc | Devices and method for treatment of degenerative joint diseases with electromagnetic fields |
| US9433797B2 (en) | 2003-12-05 | 2016-09-06 | Rio Grande Neurosciences, Inc. | Apparatus and method for electromagnetic treatment of neurodegenerative conditions |
| US10350428B2 (en) | 2014-11-04 | 2019-07-16 | Endonovo Therapetics, Inc. | Method and apparatus for electromagnetic treatment of living systems |
| US9440089B2 (en) | 2003-12-05 | 2016-09-13 | Rio Grande Neurosciences, Inc. | Apparatus and method for electromagnetic treatment of neurological injury or condition caused by a stroke |
| US20060212077A1 (en) * | 2005-03-07 | 2006-09-21 | Pilla Arthur A | Electromagnetic treatment apparatus for augmenting wound repair and method for using same |
| US9415233B2 (en) | 2003-12-05 | 2016-08-16 | Rio Grande Neurosciences, Inc. | Apparatus and method for electromagnetic treatment of neurological pain |
| US9656096B2 (en) | 2003-12-05 | 2017-05-23 | Rio Grande Neurosciences, Inc. | Method and apparatus for electromagnetic enhancement of biochemical signaling pathways for therapeutics and prophylaxis in plants, animals and humans |
| US20070026514A1 (en) * | 2005-03-07 | 2007-02-01 | Pilla Arthur A | Electromagnetic treatment apparatus for enhancing pharmacological, chemical, and topical agent effectiveness and method for using same |
| US7783353B2 (en) | 2003-12-24 | 2010-08-24 | Cardiac Pacemakers, Inc. | Automatic neural stimulation modulation based on activity and circadian rhythm |
| EP1706178B1 (en) | 2004-01-22 | 2013-04-24 | Rehabtronics Inc. | System for routing electrical current to bodily tissues via implanted passive conductors |
| US7647112B2 (en) | 2004-02-11 | 2010-01-12 | Ethicon, Inc. | System and method for selectively stimulating different body parts |
| US8165695B2 (en) * | 2004-02-11 | 2012-04-24 | Ethicon, Inc. | System and method for selectively stimulating different body parts |
| US8751003B2 (en) | 2004-02-11 | 2014-06-10 | Ethicon, Inc. | Conductive mesh for neurostimulation |
| US7979137B2 (en) | 2004-02-11 | 2011-07-12 | Ethicon, Inc. | System and method for nerve stimulation |
| US8182501B2 (en) | 2004-02-27 | 2012-05-22 | Ethicon Endo-Surgery, Inc. | Ultrasonic surgical shears and method for sealing a blood vessel using same |
| US8070703B2 (en) * | 2004-03-10 | 2011-12-06 | Vision Quest Industries Incorporated | Electrically stimulating orthotic device and segmented liner |
| US8454543B2 (en) * | 2004-03-10 | 2013-06-04 | Vision Quest Industries Incorporated | Electrodes for orthotic device |
| US8936560B2 (en) * | 2004-03-10 | 2015-01-20 | Vision Quest Industries Incorporated | Bracing and electrostimulation for arthritis |
| BRPI0509444A (pt) | 2004-04-19 | 2007-09-04 | Ivivi Technologies Inc | método para o tratamento eletromagnético de tecidos e células vivos através da intensificação da angiogênese e da neovascularização, aparelho de tratamento eletromagnético e dispositivo gerador de sinais eletromagnéticos |
| US20060030906A1 (en) * | 2004-08-06 | 2006-02-09 | Carroll William J | Switchable and programmable electrode configuration |
| US7509165B2 (en) * | 2004-08-12 | 2009-03-24 | Avazzia, Inc. | Biofeedback electronic stimulation device |
| WO2006042210A2 (en) | 2004-10-08 | 2006-04-20 | Ethicon Endo-Surgery, Inc. | Ultrasonic surgical instrument |
| WO2006057734A1 (en) * | 2004-10-21 | 2006-06-01 | Advanced Neuromodulation Systems, Inc. | New stimulation design for neuromodulation |
| US20060155220A1 (en) * | 2004-12-07 | 2006-07-13 | Oslay Theodore F | Method and device for current assisted massage for correction of soft tissue dysfunction in humans |
| US20060136011A1 (en) * | 2004-12-17 | 2006-06-22 | Paul Vo Quang Dang | Electronic healthcare device |
| US20070088407A1 (en) * | 2005-02-01 | 2007-04-19 | Smith Timothy B | Method and device for treating injuries |
| US7319902B2 (en) * | 2005-05-09 | 2008-01-15 | O'kelly Gregory | Method and device for electrochemical rejuvenation of skin and underlying tissue, and muscle building |
| PL1888162T3 (pl) * | 2005-06-03 | 2016-01-29 | Medrelief Inc | System do modulowania wzrostu chrzęstno-kostnego przy użyciu terapii impulsowym polem elektromagnetycznym |
| US7840272B2 (en) | 2005-06-03 | 2010-11-23 | Medrelief Inc. | Methods for modulating osteochondral development using bioelectrical stimulation |
| US20080039901A1 (en) * | 2005-06-03 | 2008-02-14 | Kronberg James W | Methods for modulating chondrocyte proliferation using pulsing electric fields |
| US20070276449A1 (en) * | 2005-06-15 | 2007-11-29 | Med-Lectric Corporation | Interactive transcutaneous electrical nerve stimulation device |
| EP1898782B1 (en) | 2005-07-01 | 2016-04-06 | Impedimed Limited | Monitoring system |
| EP1898784B1 (en) | 2005-07-01 | 2016-05-18 | Impedimed Limited | Method and apparatus for performing impedance measurements |
| US7912541B2 (en) * | 2005-08-12 | 2011-03-22 | Avazzia, Inc. | Biofeedback electronic stimulation device using light and magnetic energy |
| US20070073354A1 (en) * | 2005-09-26 | 2007-03-29 | Knudson Mark B | Neural blocking therapy |
| WO2007039786A1 (en) * | 2005-10-06 | 2007-04-12 | Antonio La Gatta | Generation radiant energy device |
| US9724012B2 (en) | 2005-10-11 | 2017-08-08 | Impedimed Limited | Hydration status monitoring |
| US20070191713A1 (en) | 2005-10-14 | 2007-08-16 | Eichmann Stephen E | Ultrasonic device for cutting and coagulating |
| US20090254148A1 (en) * | 2005-10-21 | 2009-10-08 | Borgens Richard B | Telemetrically Controllable System for Treatment of Nervous Sytem Injury |
| US10716749B2 (en) * | 2005-11-03 | 2020-07-21 | Palo Alto Investors | Methods and compositions for treating a renal disease condition in a subject |
| US8983628B2 (en) * | 2009-03-20 | 2015-03-17 | ElectroCore, LLC | Non-invasive vagal nerve stimulation to treat disorders |
| US20070167990A1 (en) * | 2006-01-17 | 2007-07-19 | Theranova, Llc | Method and apparatus for low frequency induction therapy for the treatment of urinary incontinence and overactive bladder |
| US9339641B2 (en) | 2006-01-17 | 2016-05-17 | Emkinetics, Inc. | Method and apparatus for transdermal stimulation over the palmar and plantar surfaces |
| WO2011053607A1 (en) | 2009-10-26 | 2011-05-05 | Emkinetics, Inc. | Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues |
| US9610459B2 (en) | 2009-07-24 | 2017-04-04 | Emkinetics, Inc. | Cooling systems and methods for conductive coils |
| US7621930B2 (en) | 2006-01-20 | 2009-11-24 | Ethicon Endo-Surgery, Inc. | Ultrasound medical instrument having a medical ultrasonic blade |
| US8027718B2 (en) * | 2006-03-07 | 2011-09-27 | Mayo Foundation For Medical Education And Research | Regional anesthetic |
| WO2007113775A2 (en) * | 2006-04-05 | 2007-10-11 | Ro-Tec B.V.B.A. | Appliance and sequence of pulses for the application of electrotherapy |
| JP2010505471A (ja) | 2006-10-02 | 2010-02-25 | エムキネティクス， インコーポレイテッド | 磁気誘導療法のための方法および装置 |
| US10786669B2 (en) | 2006-10-02 | 2020-09-29 | Emkinetics, Inc. | Method and apparatus for transdermal stimulation over the palmar and plantar surfaces |
| US11224742B2 (en) | 2006-10-02 | 2022-01-18 | Emkinetics, Inc. | Methods and devices for performing electrical stimulation to treat various conditions |
| US9005102B2 (en) | 2006-10-02 | 2015-04-14 | Emkinetics, Inc. | Method and apparatus for electrical stimulation therapy |
| WO2008046361A1 (en) * | 2006-10-20 | 2008-04-24 | Pavlov Vladimir A | Electro-energy apparatus and application of electric current frequency for normalization of nerve centres |
| US8175713B1 (en) * | 2007-01-10 | 2012-05-08 | Jozef Cywinski | Electro-stimulation device to pump blood from legs |
| US20080288019A1 (en) * | 2007-01-31 | 2008-11-20 | Adam Heller | Electrochemical management of pain |
| US8034014B2 (en) | 2007-03-06 | 2011-10-11 | Biomet Biologics, Llc | Angiogenesis initation and growth |
| US8068918B2 (en) | 2007-03-09 | 2011-11-29 | Enteromedics Inc. | Remote monitoring and control of implantable devices |
| US8423148B1 (en) * | 2007-03-19 | 2013-04-16 | Michael Lytinas | Method for treating cartilage defects |
| US8226675B2 (en) | 2007-03-22 | 2012-07-24 | Ethicon Endo-Surgery, Inc. | Surgical instruments |
| US8911460B2 (en) | 2007-03-22 | 2014-12-16 | Ethicon Endo-Surgery, Inc. | Ultrasonic surgical instruments |
| US8057498B2 (en) | 2007-11-30 | 2011-11-15 | Ethicon Endo-Surgery, Inc. | Ultrasonic surgical instrument blades |
| US8142461B2 (en) | 2007-03-22 | 2012-03-27 | Ethicon Endo-Surgery, Inc. | Surgical instruments |
| WO2008128281A1 (en) | 2007-04-20 | 2008-10-30 | Impedimed Limited | Monitoring system and probe |
| US20080300657A1 (en) | 2007-05-31 | 2008-12-04 | Mark Raymond Stultz | Therapy system |
| WO2008151300A1 (en) * | 2007-06-05 | 2008-12-11 | Reliant Technologies, Inc. | Method for reducing pain of dermatological treatments |
| US8159312B2 (en) * | 2007-06-27 | 2012-04-17 | Medrelief Inc. | Method and system for signal coupling and direct current blocking |
| EP3088045B1 (en) | 2007-07-20 | 2019-06-19 | Boston Scientific Neuromodulation Corporation | Use of stimulation pulse shape to control neural recruitment order and clinical effect |
| US11376435B2 (en) | 2007-07-20 | 2022-07-05 | Boston Scientific Neuromodulation Corporation | System and method for shaped phased current delivery |
| US20130304152A1 (en) * | 2012-05-14 | 2013-11-14 | Boston Scientific Neuromodulation Corporation | System and method for shaped phased current delivery |
| US8523889B2 (en) | 2007-07-27 | 2013-09-03 | Ethicon Endo-Surgery, Inc. | Ultrasonic end effectors with increased active length |
| US8882791B2 (en) | 2007-07-27 | 2014-11-11 | Ethicon Endo-Surgery, Inc. | Ultrasonic surgical instruments |
| US8808319B2 (en) | 2007-07-27 | 2014-08-19 | Ethicon Endo-Surgery, Inc. | Surgical instruments |
| US8430898B2 (en) | 2007-07-31 | 2013-04-30 | Ethicon Endo-Surgery, Inc. | Ultrasonic surgical instruments |
| US9044261B2 (en) | 2007-07-31 | 2015-06-02 | Ethicon Endo-Surgery, Inc. | Temperature controlled ultrasonic surgical instruments |
| US8512365B2 (en) | 2007-07-31 | 2013-08-20 | Ethicon Endo-Surgery, Inc. | Surgical instruments |
| AU2008286194B2 (en) | 2007-08-09 | 2014-05-15 | Impedimed Limited | Impedance measurement process |
| US20090048504A1 (en) * | 2007-08-17 | 2009-02-19 | Biofisica Inc. | Medical electrode systems and methods |
| US8738137B2 (en) | 2007-08-23 | 2014-05-27 | Bioness Inc. | System for transmitting electrical current to a bodily tissue |
| US9757554B2 (en) | 2007-08-23 | 2017-09-12 | Bioness Inc. | System for transmitting electrical current to a bodily tissue |
| WO2009037721A1 (en) * | 2007-09-18 | 2009-03-26 | Giuseppe Marineo | Apparatus and method for quick pain suppression |
| US7813804B1 (en) * | 2007-09-28 | 2010-10-12 | Boston Scientific Neuromodulation Corporation | Methods and systems for treating a nerve compression syndrome |
| US8352026B2 (en) | 2007-10-03 | 2013-01-08 | Ethicon, Inc. | Implantable pulse generators and methods for selective nerve stimulation |
| US8623027B2 (en) | 2007-10-05 | 2014-01-07 | Ethicon Endo-Surgery, Inc. | Ergonomic surgical instruments |
| US20090204173A1 (en) | 2007-11-05 | 2009-08-13 | Zi-Ping Fang | Multi-Frequency Neural Treatments and Associated Systems and Methods |
| US20090132010A1 (en) * | 2007-11-19 | 2009-05-21 | Kronberg James W | System and method for generating complex bioelectric stimulation signals while conserving power |
| US9089707B2 (en) | 2008-07-02 | 2015-07-28 | The Board Of Regents, The University Of Texas System | Systems, methods and devices for paired plasticity |
| US8457757B2 (en) * | 2007-11-26 | 2013-06-04 | Micro Transponder, Inc. | Implantable transponder systems and methods |
| US10010339B2 (en) | 2007-11-30 | 2018-07-03 | Ethicon Llc | Ultrasonic surgical blades |
| US20090149732A1 (en) * | 2007-12-08 | 2009-06-11 | Weinstock Ronald J | System for use of electrical resonant frequencies in analyzing and treating abnormality of human and animal tissues |
| DE102008004241B4 (de) * | 2008-01-14 | 2012-01-12 | Erbe Elektromedizin Gmbh | Verfahren zur Steuerung eines elektrochirurgischen HF-Generators sowie Elektrochirurgiegerät |
| US8874223B2 (en) | 2008-02-01 | 2014-10-28 | Prev Biotech Inc. | Mitigation of pressure ulcers using electrical stimulation |
| US20110112604A1 (en) * | 2008-02-01 | 2011-05-12 | The Governors Of The University Of Alberta | Mitigation of pressure ulcers using electrical stimulation |
| GB2457470A (en) * | 2008-02-13 | 2009-08-19 | Pulse Medical Technologies Ltd | Silver ion wound dressing with electromagnetic coil |
| US8340775B1 (en) | 2008-04-14 | 2012-12-25 | Advanced Neuromodulation Systems, Inc. | System and method for defining stimulation programs including burst and tonic stimulation |
| AU2009259904A1 (en) * | 2008-06-20 | 2009-12-23 | Medrelief Inc. | Systems, apparatuses, and methods for providing non-transcranial electrotherapy |
| US20090326612A1 (en) * | 2008-06-26 | 2009-12-31 | Michael J. Distler | Electronic biofeedback stimulation device |
| US20090326602A1 (en) * | 2008-06-27 | 2009-12-31 | Arkady Glukhovsky | Treatment of indications using electrical stimulation |
| US8630714B1 (en) * | 2008-06-30 | 2014-01-14 | Electrostim Medical Services, Inc. | Bone growth stimulation using a constant current capacitively coupled stimulator |
| US20100324627A1 (en) * | 2008-07-28 | 2010-12-23 | Newlife Sciences, Llc | Method and apparatus for resistivity measurement, detection and treatment in living tissue |
| JP5309765B2 (ja) | 2008-07-29 | 2013-10-09 | 富士通株式会社 | 情報アクセス・システム、情報記憶装置、および読取り書込み装置 |
| US9089360B2 (en) | 2008-08-06 | 2015-07-28 | Ethicon Endo-Surgery, Inc. | Devices and techniques for cutting and coagulating tissue |
| US8058771B2 (en) | 2008-08-06 | 2011-11-15 | Ethicon Endo-Surgery, Inc. | Ultrasonic device for cutting and coagulating with stepped output |
| EP2154240A1 (en) * | 2008-08-06 | 2010-02-17 | UToC B.V. i.o | PRF in cell and tissue culture |
| CN102215908A (zh) * | 2008-09-19 | 2011-10-12 | 特里·威廉·伯顿·摩尔 | 通过电处理减轻肌紧张的方法和设备 |
| US8255057B2 (en) | 2009-01-29 | 2012-08-28 | Nevro Corporation | Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions |
| US8897885B2 (en) | 2008-12-19 | 2014-11-25 | Ethicon, Inc. | Optimizing the stimulus current in a surface based stimulation device |
| US8882758B2 (en) * | 2009-01-09 | 2014-11-11 | Solta Medical, Inc. | Tissue treatment apparatus and systems with pain mitigation and methods for mitigating pain during tissue treatments |
| US8506506B2 (en) * | 2009-01-12 | 2013-08-13 | Solta Medical, Inc. | Tissue treatment apparatus with functional mechanical stimulation and methods for reducing pain during tissue treatments |
| US8326426B2 (en) | 2009-04-03 | 2012-12-04 | Enteromedics, Inc. | Implantable device with heat storage |
| EP2243510B1 (en) | 2009-04-22 | 2014-04-09 | Nevro Corporation | Sytems for selective high frequency spinal cord modulation for inhibiting pain with reduced side effects |
| WO2010124128A1 (en) | 2009-04-22 | 2010-10-28 | Nevro Corporation | Spinal cord modulation for inducing paresthetic and anesthetic effects, and associated systems and methods |
| US9700339B2 (en) | 2009-05-20 | 2017-07-11 | Ethicon Endo-Surgery, Inc. | Coupling arrangements and methods for attaching tools to ultrasonic surgical instruments |
| US8344596B2 (en) | 2009-06-24 | 2013-01-01 | Ethicon Endo-Surgery, Inc. | Transducer arrangements for ultrasonic surgical instruments |
| US8663220B2 (en) | 2009-07-15 | 2014-03-04 | Ethicon Endo-Surgery, Inc. | Ultrasonic surgical instruments |
| US8461744B2 (en) | 2009-07-15 | 2013-06-11 | Ethicon Endo-Surgery, Inc. | Rotating transducer mount for ultrasonic surgical instruments |
| US8788060B2 (en) | 2009-07-16 | 2014-07-22 | Solta Medical, Inc. | Tissue treatment systems with high powered functional electrical stimulation and methods for reducing pain during tissue treatments |
| AU2010275413A1 (en) | 2009-07-23 | 2012-02-09 | Emkinetics, Inc. | Method and apparatus for magnetic induction therapy |
| US8498710B2 (en) | 2009-07-28 | 2013-07-30 | Nevro Corporation | Linked area parameter adjustment for spinal cord stimulation and associated systems and methods |
| WO2011015998A1 (en) * | 2009-08-04 | 2011-02-10 | Lifewave Ltd. | Methods of diagnosis and of screening for electrical markers for hidden maladies |
| US8428738B2 (en) * | 2009-08-26 | 2013-04-23 | Andrew D. Valencia | Coupled neuraxial mesoscopic desynchronization electrostimulation therapy (cNMDET) method |
| MX2012001181A (es) | 2009-09-21 | 2012-04-30 | Medtronic Inc | Ondas para terapia de estimulacion electrica. |
| WO2011044159A1 (en) * | 2009-10-05 | 2011-04-14 | Arp Manufacturing Llc | Electro-therapeutic stimulator |
| USRE47996E1 (en) | 2009-10-09 | 2020-05-19 | Ethicon Llc | Surgical generator for ultrasonic and electrosurgical devices |
| US9050093B2 (en) | 2009-10-09 | 2015-06-09 | Ethicon Endo-Surgery, Inc. | Surgical generator for ultrasonic and electrosurgical devices |
| US9168054B2 (en) * | 2009-10-09 | 2015-10-27 | Ethicon Endo-Surgery, Inc. | Surgical generator for ultrasonic and electrosurgical devices |
| US10441345B2 (en) | 2009-10-09 | 2019-10-15 | Ethicon Llc | Surgical generator for ultrasonic and electrosurgical devices |
| US11090104B2 (en) | 2009-10-09 | 2021-08-17 | Cilag Gmbh International | Surgical generator for ultrasonic and electrosurgical devices |
| JP5643829B2 (ja) | 2009-10-26 | 2014-12-17 | インぺディメッド リミテッドＩｍｐｅｄｉｍｅｄ Ｌｉｍｉｔｅｄ | インピーダンス測定の分析において用いるための方法及び装置 |
| AU2010321683B2 (en) | 2009-11-18 | 2014-06-26 | Impedimed Limited | Signal distribution for patient-electrode measurements |
| US8961547B2 (en) | 2010-02-11 | 2015-02-24 | Ethicon Endo-Surgery, Inc. | Ultrasonic surgical instruments with moving cutting implement |
| US8486096B2 (en) | 2010-02-11 | 2013-07-16 | Ethicon Endo-Surgery, Inc. | Dual purpose surgical instrument for cutting and coagulating tissue |
| US8469981B2 (en) | 2010-02-11 | 2013-06-25 | Ethicon Endo-Surgery, Inc. | Rotatable cutting implement arrangements for ultrasonic surgical instruments |
| US8579928B2 (en) | 2010-02-11 | 2013-11-12 | Ethicon Endo-Surgery, Inc. | Outer sheath and blade arrangements for ultrasonic surgical instruments |
| US8951272B2 (en) | 2010-02-11 | 2015-02-10 | Ethicon Endo-Surgery, Inc. | Seal arrangements for ultrasonically powered surgical instruments |
| US8682448B2 (en) * | 2010-03-11 | 2014-03-25 | Emc2 Holdings Llc | EMF probe configurations for electro-modulation of ionic channels of cells and methods of use thereof |
| EP2547397A4 (en) * | 2010-03-18 | 2014-05-14 | Ronald J Weinstock | SYSTEM FOR DIAGNOSIS AND TREATMENT OF DIABETES SYMPTOMS |
| GB2480498A (en) | 2010-05-21 | 2011-11-23 | Ethicon Endo Surgery Inc | Medical device comprising RF circuitry |
| US8588884B2 (en) | 2010-05-28 | 2013-11-19 | Emkinetics, Inc. | Microneedle electrode |
| US20110306921A1 (en) * | 2010-06-10 | 2011-12-15 | Protopeutics, Incorporated | Therapeutic device and methods of using and making same for multimodal stimulation of living tissue |
| JP5838557B2 (ja) | 2010-07-05 | 2016-01-06 | ソニー株式会社 | 生体情報処理方法および装置、並びに記録媒体 |
| US8795327B2 (en) | 2010-07-22 | 2014-08-05 | Ethicon Endo-Surgery, Inc. | Electrosurgical instrument with separate closure and cutting members |
| US9192431B2 (en) | 2010-07-23 | 2015-11-24 | Ethicon Endo-Surgery, Inc. | Electrosurgical cutting and sealing instrument |
| WO2012045079A2 (en) | 2010-10-01 | 2012-04-05 | Ivivi Health Sciences, Llc | Method and apparatus for electromagnetic treatment of head cerebral and neural injury in animals and humans |
| WO2012051495A2 (en) | 2010-10-15 | 2012-04-19 | The Research Foundation Of State University Of New York | Compositions and methods for enhancing the biological response to chemical agents and physical stimuli |
| JP5367800B2 (ja) * | 2010-11-09 | 2013-12-11 | 株式会社 資生堂 | コンテンツ再生装置、コンテンツ再生方法、及びコンテンツ再生プログラム |
| WO2012075198A2 (en) | 2010-11-30 | 2012-06-07 | Nevro Corporation | Extended pain relief via high frequency spinal cord modulation, and associated systems and methods |
| US10085670B2 (en) | 2010-11-30 | 2018-10-02 | Newlife Sciences Llc | Apparatus and method for treatment of pain with body impedance analyzer |
| US8275461B2 (en) * | 2010-12-02 | 2012-09-25 | Xavant Technology | Pain relieving waveform system and method |
| AU2012204526B2 (en) | 2011-01-03 | 2016-05-19 | California Institute Of Technology | High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury |
| US20120197356A1 (en) * | 2011-01-27 | 2012-08-02 | Medtronic, Inc. | Waveforms for Remote Electrical Stimulation Therapy |
| US9168374B2 (en) | 2011-01-28 | 2015-10-27 | Medtronic, Inc. | Intra-burst pulse variation for stimulation therapy |
| TWI426285B (zh) * | 2011-02-11 | 2014-02-11 | Univ Nat Taiwan | 擾動自我測試電路 |
| TWI446944B (zh) | 2011-05-13 | 2014-08-01 | Univ Nat Chiao Tung | 具負載適應性之生物電流刺激器 |
| KR101093103B1 (ko) * | 2011-06-09 | 2011-12-13 | 김미승 | 주파수 패턴을 이용한 전기 자극기 |
| US9259265B2 (en) | 2011-07-22 | 2016-02-16 | Ethicon Endo-Surgery, Llc | Surgical instruments for tensioning tissue |
| EP2736588A4 (en) | 2011-07-27 | 2015-06-10 | Vision Quest Ind Inc Dba Vq Orthocare | ELECTROSTIMULATION SYSTEM |
| US9566426B2 (en) * | 2011-08-31 | 2017-02-14 | ElectroCore, LLC | Systems and methods for vagal nerve stimulation |
| WO2013036880A1 (en) * | 2011-09-08 | 2013-03-14 | Thacker James R | Selective high frequency spinal cord modulation for inhibiting pain, including cephalic and/or total body pain with reduced side effects, and associated systems and methods |
| US9393409B2 (en) | 2011-11-11 | 2016-07-19 | Neuroenabling Technologies, Inc. | Non invasive neuromodulation device for enabling recovery of motor, sensory, autonomic, sexual, vasomotor and cognitive function |
| AU2012351988B2 (en) | 2011-12-14 | 2017-05-04 | Impedimed Limited | Devices, systems and methods for determining the relative spatial change in subsurface resistivities across frequencies in tissue |
| US8343027B1 (en) | 2012-01-30 | 2013-01-01 | Ivivi Health Sciences, Llc | Methods and devices for providing electromagnetic treatment in the presence of a metal-containing implant |
| WO2013119545A1 (en) | 2012-02-10 | 2013-08-15 | Ethicon-Endo Surgery, Inc. | Robotically controlled surgical instrument |
| US8676331B2 (en) | 2012-04-02 | 2014-03-18 | Nevro Corporation | Devices for controlling spinal cord modulation for inhibiting pain, and associated systems and methods, including controllers for automated parameter selection |
| US9237921B2 (en) | 2012-04-09 | 2016-01-19 | Ethicon Endo-Surgery, Inc. | Devices and techniques for cutting and coagulating tissue |
| US9226766B2 (en) | 2012-04-09 | 2016-01-05 | Ethicon Endo-Surgery, Inc. | Serial communication protocol for medical device |
| US9241731B2 (en) | 2012-04-09 | 2016-01-26 | Ethicon Endo-Surgery, Inc. | Rotatable electrical connection for ultrasonic surgical instruments |
| US9724118B2 (en) | 2012-04-09 | 2017-08-08 | Ethicon Endo-Surgery, Llc | Techniques for cutting and coagulating tissue for ultrasonic surgical instruments |
| US9439668B2 (en) | 2012-04-09 | 2016-09-13 | Ethicon Endo-Surgery, Llc | Switch arrangements for ultrasonic surgical instruments |
| US8923976B2 (en) | 2012-04-26 | 2014-12-30 | Medtronic, Inc. | Movement patterns for electrical stimulation therapy |
| US9833614B1 (en) | 2012-06-22 | 2017-12-05 | Nevro Corp. | Autonomic nervous system control via high frequency spinal cord modulation, and associated systems and methods |
| US20140005705A1 (en) | 2012-06-29 | 2014-01-02 | Ethicon Endo-Surgery, Inc. | Surgical instruments with articulating shafts |
| US9283045B2 (en) | 2012-06-29 | 2016-03-15 | Ethicon Endo-Surgery, Llc | Surgical instruments with fluid management system |
| US9351754B2 (en) | 2012-06-29 | 2016-05-31 | Ethicon Endo-Surgery, Llc | Ultrasonic surgical instruments with distally positioned jaw assemblies |
| US9198714B2 (en) | 2012-06-29 | 2015-12-01 | Ethicon Endo-Surgery, Inc. | Haptic feedback devices for surgical robot |
| US9326788B2 (en) | 2012-06-29 | 2016-05-03 | Ethicon Endo-Surgery, Llc | Lockout mechanism for use with robotic electrosurgical device |
| US9393037B2 (en) | 2012-06-29 | 2016-07-19 | Ethicon Endo-Surgery, Llc | Surgical instruments with articulating shafts |
| US9820768B2 (en) | 2012-06-29 | 2017-11-21 | Ethicon Llc | Ultrasonic surgical instruments with control mechanisms |
| US20140005702A1 (en) | 2012-06-29 | 2014-01-02 | Ethicon Endo-Surgery, Inc. | Ultrasonic surgical instruments with distally positioned transducers |
| US9408622B2 (en) | 2012-06-29 | 2016-08-09 | Ethicon Endo-Surgery, Llc | Surgical instruments with articulating shafts |
| US9226767B2 (en) | 2012-06-29 | 2016-01-05 | Ethicon Endo-Surgery, Inc. | Closed feedback control for electrosurgical device |
| US9259343B2 (en) | 2012-07-06 | 2016-02-16 | Newman Technologies LLC | Device for mitigating plantar fasciitis |
| WO2014052181A1 (en) | 2012-09-28 | 2014-04-03 | Ethicon Endo-Surgery, Inc. | Multi-function bi-polar forceps |
| US10201365B2 (en) | 2012-10-22 | 2019-02-12 | Ethicon Llc | Surgeon feedback sensing and display methods |
| US9095367B2 (en) | 2012-10-22 | 2015-08-04 | Ethicon Endo-Surgery, Inc. | Flexible harmonic waveguides/blades for surgical instruments |
| US20140135804A1 (en) | 2012-11-15 | 2014-05-15 | Ethicon Endo-Surgery, Inc. | Ultrasonic and electrosurgical devices |
| US10814131B2 (en) | 2012-11-26 | 2020-10-27 | Thync Global, Inc. | Apparatuses and methods for neuromodulation |
| WO2014082064A1 (en) * | 2012-11-26 | 2014-05-30 | Thync, Inc. | Wearable transdermal electrical stimulation devices and methods of using them |
| US10537703B2 (en) | 2012-11-26 | 2020-01-21 | Thync Global, Inc. | Systems and methods for transdermal electrical stimulation to improve sleep |
| US9440070B2 (en) | 2012-11-26 | 2016-09-13 | Thyne Global, Inc. | Wearable transdermal electrical stimulation devices and methods of using them |
| US10485972B2 (en) | 2015-02-27 | 2019-11-26 | Thync Global, Inc. | Apparatuses and methods for neuromodulation |
| US9295854B2 (en) | 2012-11-28 | 2016-03-29 | Point Source, Inc. | Light and bioelectric therapy pad |
| CA2905042A1 (en) | 2012-12-14 | 2014-06-19 | Case Western Reserve University | Methods of treating medical conditions by population based encoding of neural information |
| WO2014105964A1 (en) * | 2012-12-27 | 2014-07-03 | The General Hospital Corporation | Systems and methods for delivering pulsed electric fields to skin tissue |
| WO2014123949A1 (en) | 2013-02-05 | 2014-08-14 | Ohio State Innovation Foundation | A non-contact method for accelerating wound healing |
| US9885031B2 (en) | 2013-02-05 | 2018-02-06 | Ohio State Innovation Foundation | Galvanotaxis assay for quantitative assessment of the metastatic potential of cancer cells |
| WO2014123947A1 (en) | 2013-02-05 | 2014-08-14 | Ohio State Innovation Foundation | A galvanotaxis assay for quantitative assessment of the metastatic potential of cancer cells |
| US9108055B1 (en) | 2013-02-12 | 2015-08-18 | Vincent Tellenbach | System for electrical muscle and nerve stimulation in aqueous media |
| US9724535B1 (en) * | 2013-02-19 | 2017-08-08 | Blugreen Technologies, Inc. | Low frequency magnetic pulse variable resonator for actively influencing the interaction and intercommunication at the cellular level for biological organisms and molecular level of matter |
| US9174053B2 (en) | 2013-03-08 | 2015-11-03 | Boston Scientific Neuromodulation Corporation | Neuromodulation using modulated pulse train |
| US10226273B2 (en) | 2013-03-14 | 2019-03-12 | Ethicon Llc | Mechanical fasteners for use with surgical energy devices |
| US9241728B2 (en) | 2013-03-15 | 2016-01-26 | Ethicon Endo-Surgery, Inc. | Surgical instrument with multiple clamping mechanisms |
| US9119966B2 (en) * | 2013-05-10 | 2015-09-01 | Case Western Reserve University | Systems and methods that provide an electrical waveform for neural stimulation or nerve block |
| US11229789B2 (en) | 2013-05-30 | 2022-01-25 | Neurostim Oab, Inc. | Neuro activator with controller |
| CN105307719B (zh) | 2013-05-30 | 2018-05-29 | 格雷厄姆·H.·克雷西 | 局部神经刺激仪 |
| US9895539B1 (en) | 2013-06-10 | 2018-02-20 | Nevro Corp. | Methods and systems for disease treatment using electrical stimulation |
| EP3013414B1 (en) | 2013-06-29 | 2018-09-19 | Cerevast Medical Inc. | Transdermal electrical stimulation devices and methods for modifying or inducing cognitive state |
| US10293161B2 (en) | 2013-06-29 | 2019-05-21 | Thync Global, Inc. | Apparatuses and methods for transdermal electrical stimulation of nerves to modify or induce a cognitive state |
| EP3016583A4 (en) * | 2013-07-01 | 2017-03-22 | Impedimed Limited | Apparatuses for home use in determining tissue wetness |
| US9814514B2 (en) | 2013-09-13 | 2017-11-14 | Ethicon Llc | Electrosurgical (RF) medical instruments for cutting and coagulating tissue |
| SG11201602003QA (en) * | 2013-09-17 | 2016-04-28 | Rising Tide Foundation | Venous electrical stimulation apparatus and methods |
| EP3049148B1 (en) | 2013-09-27 | 2020-05-20 | The Regents Of The University Of California | Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects |
| CN103519797A (zh) * | 2013-10-25 | 2014-01-22 | 江苏美伦影像系统有限公司 | 一种基于fpga的生物医学信号发生器 |
| US10149978B1 (en) | 2013-11-07 | 2018-12-11 | Nevro Corp. | Spinal cord modulation for inhibiting pain via short pulse width waveforms, and associated systems and methods |
| US9265926B2 (en) | 2013-11-08 | 2016-02-23 | Ethicon Endo-Surgery, Llc | Electrosurgical devices |
| GB2521228A (en) | 2013-12-16 | 2015-06-17 | Ethicon Endo Surgery Inc | Medical device |
| JP2016540594A (ja) * | 2013-12-16 | 2016-12-28 | ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎ Ｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ | 神経刺激用のパターン化された刺激強度 |
| GB2521229A (en) | 2013-12-16 | 2015-06-17 | Ethicon Endo Surgery Inc | Medical device |
| US9795436B2 (en) | 2014-01-07 | 2017-10-24 | Ethicon Llc | Harvesting energy from a surgical generator |
| EP3096834A1 (en) * | 2014-01-21 | 2016-11-30 | Cerephex Corporation | Methods and apparatus for electrical stimulation |
| WO2015131093A1 (en) | 2014-02-27 | 2015-09-03 | Thync, Inc. | Methods and apparatuses for user control of neurostimulation |
| WO2015127560A1 (en) * | 2014-02-28 | 2015-09-03 | The Governing Council Of The University Of Toronto | Selective, directable electrotaxis of precursor cells with biphasic electrical stimulation |
| JP6424402B2 (ja) * | 2014-02-28 | 2018-11-21 | バイオアイ株式会社 | 生体電気刺激装置 |
| US9554854B2 (en) | 2014-03-18 | 2017-01-31 | Ethicon Endo-Surgery, Llc | Detecting short circuits in electrosurgical medical devices |
| US10092310B2 (en) | 2014-03-27 | 2018-10-09 | Ethicon Llc | Electrosurgical devices |
| US10463421B2 (en) | 2014-03-27 | 2019-11-05 | Ethicon Llc | Two stage trigger, clamp and cut bipolar vessel sealer |
| US9737355B2 (en) | 2014-03-31 | 2017-08-22 | Ethicon Llc | Controlling impedance rise in electrosurgical medical devices |
| US9913680B2 (en) | 2014-04-15 | 2018-03-13 | Ethicon Llc | Software algorithms for electrosurgical instruments |
| US9320913B2 (en) | 2014-04-16 | 2016-04-26 | Rio Grande Neurosciences, Inc. | Two-part pulsed electromagnetic field applicator for application of therapeutic energy |
| CN103933662A (zh) * | 2014-05-05 | 2014-07-23 | 重庆新大地电子有限公司 | 生物负电子靶向治疗带 |
| JP5636129B1 (ja) * | 2014-05-16 | 2014-12-03 | 株式会社テクノリンク | 呼吸異常改善装置 |
| EP3148639A4 (en) | 2014-05-17 | 2018-04-18 | Cerevast Medical Inc. | Methods and apparatuses for the application of ensemble waveforms using transdermal neurostimulation |
| US9333334B2 (en) | 2014-05-25 | 2016-05-10 | Thync, Inc. | Methods for attaching and wearing a neurostimulator |
| KR20170063440A (ko) | 2014-05-25 | 2017-06-08 | 하이인 에쿼티 인베스트먼트 펀드 엘.피. | 웨어러블 경피 신경자극기들 |
| JP6437019B2 (ja) | 2014-07-03 | 2018-12-12 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 柔軟なパターン形成及び波形を有する神経刺激システム |
| US9968301B2 (en) | 2014-07-09 | 2018-05-15 | The Board Of Regents, The University Of Texas System | Body-driven pseudorandom signal injection for biomedical acquisition channel calibration |
| US10285724B2 (en) | 2014-07-31 | 2019-05-14 | Ethicon Llc | Actuation mechanisms and load adjustment assemblies for surgical instruments |
| US10086198B1 (en) | 2014-10-10 | 2018-10-02 | Apogee Medical, Llc | Electrostimulation principle, method and device for impedance change theoretically enhancing calcium-calmodulin binding |
| US9597507B2 (en) | 2014-10-31 | 2017-03-21 | Medtronic, Inc. | Paired stimulation pulses based on sensed compound action potential |
| US9956404B2 (en) | 2014-11-19 | 2018-05-01 | Medtronic, Inc. | Electrical stimulation to inhibit bladder and/or bowel contraction |
| US20160144171A1 (en) * | 2014-11-25 | 2016-05-26 | TrioWave Technologies | Systems and methods for generating biphasic waveforms |
| US10639092B2 (en) | 2014-12-08 | 2020-05-05 | Ethicon Llc | Electrode configurations for surgical instruments |
| US11534608B2 (en) * | 2015-01-04 | 2022-12-27 | Ist, Llc | Methods and apparatuses for transdermal stimulation of the outer ear |
| US10426945B2 (en) * | 2015-01-04 | 2019-10-01 | Thync Global, Inc. | Methods and apparatuses for transdermal stimulation of the outer ear |
| CN107427680B (zh) * | 2015-02-02 | 2021-07-16 | 诺维图姆医疗科技有限公司 | 静脉电刺激装置及其方法与应用 |
| US10245095B2 (en) | 2015-02-06 | 2019-04-02 | Ethicon Llc | Electrosurgical instrument with rotation and articulation mechanisms |
| US11077301B2 (en) | 2015-02-21 | 2021-08-03 | NeurostimOAB, Inc. | Topical nerve stimulator and sensor for bladder control |
| US10342602B2 (en) | 2015-03-17 | 2019-07-09 | Ethicon Llc | Managing tissue treatment |
| US10321950B2 (en) | 2015-03-17 | 2019-06-18 | Ethicon Llc | Managing tissue treatment |
| US10595929B2 (en) | 2015-03-24 | 2020-03-24 | Ethicon Llc | Surgical instruments with firing system overload protection mechanisms |
| US9855418B2 (en) | 2015-05-05 | 2018-01-02 | Cosmo Haralambidis | Device for electrical stimulation of peridontal complex and surrounding tissue |
| US11103696B2 (en) | 2015-05-05 | 2021-08-31 | Cosmo Haralambidis | Device for electrical stimulation of peridontal complex and surrounding tissue |
| KR101744673B1 (ko) * | 2015-05-08 | 2017-06-21 | 계명대학교 산학협력단 | 전기 자극장치를 부착한 기브스 및 이를 이용한 전기 자극방법 |
| CN105310680B (zh) * | 2015-05-14 | 2018-03-27 | 南京神桥医疗器械有限公司 | 一种植入式神经信号阻断装置 |
| WO2016191055A1 (en) | 2015-05-28 | 2016-12-01 | Boston Scientific Neuromodulation Corporation | Neuromodulation using stochastically-modulated stimulation parameters |
| WO2016196454A1 (en) | 2015-05-29 | 2016-12-08 | Cerevast Medical Inc. | Methods and apparatuses for transdermal electrical stimulation |
| US10034684B2 (en) | 2015-06-15 | 2018-07-31 | Ethicon Llc | Apparatus and method for dissecting and coagulating tissue |
| US11020140B2 (en) | 2015-06-17 | 2021-06-01 | Cilag Gmbh International | Ultrasonic surgical blade for use with ultrasonic surgical instruments |
| US10898256B2 (en) | 2015-06-30 | 2021-01-26 | Ethicon Llc | Surgical system with user adaptable techniques based on tissue impedance |
| US11129669B2 (en) | 2015-06-30 | 2021-09-28 | Cilag Gmbh International | Surgical system with user adaptable techniques based on tissue type |
| US10034704B2 (en) | 2015-06-30 | 2018-07-31 | Ethicon Llc | Surgical instrument with user adaptable algorithms |
| US11141213B2 (en) | 2015-06-30 | 2021-10-12 | Cilag Gmbh International | Surgical instrument with user adaptable techniques |
| US10357303B2 (en) | 2015-06-30 | 2019-07-23 | Ethicon Llc | Translatable outer tube for sealing using shielded lap chole dissector |
| US11051873B2 (en) | 2015-06-30 | 2021-07-06 | Cilag Gmbh International | Surgical system with user adaptable techniques employing multiple energy modalities based on tissue parameters |
| US10154852B2 (en) | 2015-07-01 | 2018-12-18 | Ethicon Llc | Ultrasonic surgical blade with improved cutting and coagulation features |
| EA201890244A1 (ru) * | 2015-07-08 | 2018-07-31 | Вэйв Форс Электроникс Инк. | Устройство, система и способ излучения биорезонансной частоты |
| US20170021173A1 (en) * | 2015-07-21 | 2017-01-26 | Andreas Peneder | System and method for medical devices and pain reduction |
| US9630012B2 (en) * | 2015-08-06 | 2017-04-25 | Meagan Medical, Inc. | Spinal cord stimulation with interferential current |
| US10598648B2 (en) | 2015-09-24 | 2020-03-24 | Frito-Lay North America, Inc. | Quantitative texture measurement apparatus and method |
| US10107785B2 (en) | 2015-09-24 | 2018-10-23 | Frito-Lay North America, Inc. | Quantitative liquid texture measurement apparatus and method |
| US11243190B2 (en) | 2015-09-24 | 2022-02-08 | Frito-Lay North America, Inc. | Quantitative liquid texture measurement method |
| US10969316B2 (en) | 2015-09-24 | 2021-04-06 | Frito-Lay North America, Inc. | Quantitative in-situ texture measurement apparatus and method |
| US9541537B1 (en) | 2015-09-24 | 2017-01-10 | Frito-Lay North America, Inc. | Quantitative texture measurement apparatus and method |
| US10070661B2 (en) | 2015-09-24 | 2018-09-11 | Frito-Lay North America, Inc. | Feedback control of food texture system and method |
| US10751108B2 (en) | 2015-09-30 | 2020-08-25 | Ethicon Llc | Protection techniques for generator for digitally generating electrosurgical and ultrasonic electrical signal waveforms |
| US10595930B2 (en) | 2015-10-16 | 2020-03-24 | Ethicon Llc | Electrode wiping surgical device |
| ES2571460B1 (es) * | 2015-10-23 | 2017-01-05 | Indiba, S.A. | Procedimiento cosmético para la reducción o prevención de la acumulación de tejido adiposo |
| US11318310B1 (en) | 2015-10-26 | 2022-05-03 | Nevro Corp. | Neuromodulation for altering autonomic functions, and associated systems and methods |
| WO2017106411A1 (en) | 2015-12-15 | 2017-06-22 | Cerevast Medical, Inc. | Electrodes having surface exclusions |
| WO2017106878A1 (en) | 2015-12-18 | 2017-06-22 | Thync Global, Inc. | Apparatuses and methods for transdermal electrical stimulation of nerves to modify or induce a cognitive state |
| US9956405B2 (en) | 2015-12-18 | 2018-05-01 | Thyne Global, Inc. | Transdermal electrical stimulation at the neck to induce neuromodulation |
| US11083896B2 (en) | 2015-12-18 | 2021-08-10 | Medtronic, Inc. | High duty cycle electrical stimulation therapy |
| US10179022B2 (en) | 2015-12-30 | 2019-01-15 | Ethicon Llc | Jaw position impedance limiter for electrosurgical instrument |
| US10575892B2 (en) | 2015-12-31 | 2020-03-03 | Ethicon Llc | Adapter for electrical surgical instruments |
| US11229471B2 (en) | 2016-01-15 | 2022-01-25 | Cilag Gmbh International | Modular battery powered handheld surgical instrument with selective application of energy based on tissue characterization |
| US11129670B2 (en) | 2016-01-15 | 2021-09-28 | Cilag Gmbh International | Modular battery powered handheld surgical instrument with selective application of energy based on button displacement, intensity, or local tissue characterization |
| US10709469B2 (en) | 2016-01-15 | 2020-07-14 | Ethicon Llc | Modular battery powered handheld surgical instrument with energy conservation techniques |
| US10716615B2 (en) | 2016-01-15 | 2020-07-21 | Ethicon Llc | Modular battery powered handheld surgical instrument with curved end effectors having asymmetric engagement between jaw and blade |
| WO2017132174A1 (en) | 2016-01-25 | 2017-08-03 | Nevro Corp. | Treatment of congestive heart failure with electrical stimulation, and associated systems and methods |
| US10555769B2 (en) | 2016-02-22 | 2020-02-11 | Ethicon Llc | Flexible circuits for electrosurgical instrument |
| DE102016105174A1 (de) * | 2016-03-21 | 2017-09-21 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Aktives Retina-Implantat |
| US10799701B2 (en) | 2016-03-30 | 2020-10-13 | Nevro Corp. | Systems and methods for identifying and treating patients with high-frequency electrical signals |
| US10420939B2 (en) * | 2016-03-31 | 2019-09-24 | The Cleveland Clinic Foundation | Nerve stimulation to promote neuroregeneration |
| US11368802B2 (en) * | 2016-04-27 | 2022-06-21 | Cochlear Limited | Implantable vibratory device using limited components |
| US10485607B2 (en) | 2016-04-29 | 2019-11-26 | Ethicon Llc | Jaw structure with distal closure for electrosurgical instruments |
| US10646269B2 (en) | 2016-04-29 | 2020-05-12 | Ethicon Llc | Non-linear jaw gap for electrosurgical instruments |
| US10702329B2 (en) | 2016-04-29 | 2020-07-07 | Ethicon Llc | Jaw structure with distal post for electrosurgical instruments |
| US10456193B2 (en) | 2016-05-03 | 2019-10-29 | Ethicon Llc | Medical device with a bilateral jaw configuration for nerve stimulation |
| US10646708B2 (en) | 2016-05-20 | 2020-05-12 | Thync Global, Inc. | Transdermal electrical stimulation at the neck |
| US11446504B1 (en) | 2016-05-27 | 2022-09-20 | Nevro Corp. | High frequency electromagnetic stimulation for modulating cells, including spontaneously active and quiescent cells, and associated systems and methods |
| JP5976977B1 (ja) * | 2016-06-17 | 2016-08-24 | 株式会社 Ｍｔｇ | 筋肉電気刺激装置 |
| US10245064B2 (en) | 2016-07-12 | 2019-04-02 | Ethicon Llc | Ultrasonic surgical instrument with piezoelectric central lumen transducer |
| US10893883B2 (en) | 2016-07-13 | 2021-01-19 | Ethicon Llc | Ultrasonic assembly for use with ultrasonic surgical instruments |
| US10842522B2 (en) | 2016-07-15 | 2020-11-24 | Ethicon Llc | Ultrasonic surgical instruments having offset blades |
| US10376305B2 (en) | 2016-08-05 | 2019-08-13 | Ethicon Llc | Methods and systems for advanced harmonic energy |
| US10285723B2 (en) | 2016-08-09 | 2019-05-14 | Ethicon Llc | Ultrasonic surgical blade with improved heel portion |
| USD847990S1 (en) | 2016-08-16 | 2019-05-07 | Ethicon Llc | Surgical instrument |
| US10525268B2 (en) | 2016-08-23 | 2020-01-07 | Medtronic, Inc. | Delivery of independent interleaved programs to produce higher-frequency electrical stimulation therapy |
| US10952759B2 (en) | 2016-08-25 | 2021-03-23 | Ethicon Llc | Tissue loading of a surgical instrument |
| US10828056B2 (en) | 2016-08-25 | 2020-11-10 | Ethicon Llc | Ultrasonic transducer to waveguide acoustic coupling, connections, and configurations |
| US10569088B2 (en) | 2016-09-16 | 2020-02-25 | Medtronic, Inc. | Dorsal spinal column characterization with evoked potentials |
| EP3522975B1 (en) | 2016-10-04 | 2021-08-04 | Medtronic, Inc. | Cathode-minimized stimulation programming |
| CN110072590B (zh) | 2016-10-28 | 2023-03-28 | 美敦力公司 | 基于低频滴定仪的高频刺激 |
| WO2018089795A1 (en) | 2016-11-10 | 2018-05-17 | Qoravita LLC | System and method for applying a low frequency magnetic field to biological tissues |
| US10603064B2 (en) | 2016-11-28 | 2020-03-31 | Ethicon Llc | Ultrasonic transducer |
| US11266430B2 (en) | 2016-11-29 | 2022-03-08 | Cilag Gmbh International | End effector control and calibration |
| WO2018101986A1 (en) | 2016-12-01 | 2018-06-07 | Thimble Bioelectronics, Inc. d/b/a Enso | Neuromodulation device and method for use |
| US11045650B2 (en) | 2016-12-06 | 2021-06-29 | Medtronic, Inc. | High frequency neurostimulation for pelvic symptom control |
| MX2019007714A (es) * | 2016-12-27 | 2019-09-09 | Avent Inc | Articulo y metodo para tratar neuropatia diabetica periferica. |
| CA3048654A1 (en) * | 2017-01-13 | 2018-07-19 | Orthofix Inc. | Systems and methods for musculoskeletal tissue treatment |
| WO2018168719A1 (ja) * | 2017-03-14 | 2018-09-20 | 西村 明美 | 周波治療器 |
| WO2018187734A1 (en) | 2017-04-07 | 2018-10-11 | Medtronic, Inc. | Complex variation of electrical stimulation therapy parameters |
| EP3974021B1 (en) | 2017-06-30 | 2023-06-14 | ONWARD Medical N.V. | A system for neuromodulation |
| US10820920B2 (en) | 2017-07-05 | 2020-11-03 | Ethicon Llc | Reusable ultrasonic medical devices and methods of their use |
| CN109420252B (zh) | 2017-08-22 | 2023-10-31 | 精能医学股份有限公司 | 电刺激装置、产生电信号的方法以及计算机可读存储介质 |
| WO2019060435A1 (en) * | 2017-09-21 | 2019-03-28 | Frito-Lay North America, Inc. | APPARATUS AND METHOD FOR QUANTITATIVE TEXTURE MEASUREMENT |
| US10987515B2 (en) | 2017-10-10 | 2021-04-27 | Medtronic, Inc. | Management of electrical stimulation therapy |
| JP2019072329A (ja) * | 2017-10-18 | 2019-05-16 | オージー技研株式会社 | 電気刺激装置 |
| CN111601636A (zh) | 2017-11-07 | 2020-08-28 | Oab神经电疗科技公司 | 具有自适应电路的非侵入性神经激活器 |
| US11052249B2 (en) * | 2017-11-21 | 2021-07-06 | Nikunj Arunkumar Bhagat | Neuromuscular stimulation using multistage current driver circuit |
| CN107800406B (zh) * | 2017-11-22 | 2021-08-24 | 北京品驰医疗设备有限公司 | 高频脉冲刺激信号生成方法、脉冲刺激方法及设备 |
| US11992684B2 (en) | 2017-12-05 | 2024-05-28 | Ecole Polytechnique Federale De Lausanne (Epfl) | System for planning and/or providing neuromodulation |
| JP6488458B1 (ja) * | 2017-12-25 | 2019-03-27 | 株式会社テクノリンク | 生体刺激装置 |
| RU2675174C1 (ru) * | 2017-12-28 | 2018-12-17 | Александра Игоревна Булава | Электродная платформа для электроболевой стимуляции животных |
| WO2019142196A1 (en) * | 2018-01-18 | 2019-07-25 | Magdent Ltd. | External electronic patch for accelerating bone healing or regeneration after trauma |
| CN108031002B (zh) * | 2018-02-08 | 2021-06-29 | 中国医科大学附属盛京医院 | 用于促进自体移植脂肪瓣再生的电刺激设备 |
| CN108355245A (zh) * | 2018-03-08 | 2018-08-03 | 广州圆医生物科技有限公司 | 一种用于神经和肌肉刺激仪的电极 |
| CN108744269B (zh) * | 2018-04-08 | 2022-04-05 | 南京艾威奇医疗器械有限公司 | 射频信号输出系统和细胞激活设备 |
| WO2019209969A1 (en) | 2018-04-24 | 2019-10-31 | Thync Global, Inc. | Streamlined and pre-set neuromodulators |
| US11129989B2 (en) | 2018-06-21 | 2021-09-28 | Medtronic, Inc. | ECAP based control of electrical stimulation therapy |
| US11129991B2 (en) | 2018-06-21 | 2021-09-28 | Medtronic, Inc. | ECAP based control of electrical stimulation therapy |
| CN113286629A (zh) * | 2018-09-03 | 2021-08-20 | 格瑞塔股份公司 | 用于刺激患者的神经元以抑制神经元的病理性同步活动的医疗装置和方法 |
| WO2020061532A1 (en) * | 2018-09-20 | 2020-03-26 | Cal-X Stars Business Accelerator, Inc. | System and method for treating inflammation |
| EP3653260A1 (en) | 2018-11-13 | 2020-05-20 | GTX medical B.V. | Sensor in clothing of limbs or footwear |
| DE18205811T1 (de) | 2018-11-13 | 2020-12-24 | Gtx Medical B.V. | Steuerungssystem zur neuromodulation mit geschlossenem regelkreis |
| EP3653256B1 (en) | 2018-11-13 | 2022-03-30 | ONWARD Medical N.V. | Control system for movement reconstruction and/or restoration for a patient |
| AU2020207940A1 (en) | 2019-01-17 | 2021-08-12 | Nevro Corp. | Sensory threshold and/or adaptation for neurological therapy screening and/or parameter selection, and associated systems and methods |
| US11590352B2 (en) | 2019-01-29 | 2023-02-28 | Nevro Corp. | Ramped therapeutic signals for modulating inhibitory interneurons, and associated systems and methods |
| EP3695878B1 (en) | 2019-02-12 | 2023-04-19 | ONWARD Medical N.V. | A system for neuromodulation |
| CN113853174B (zh) * | 2019-03-15 | 2024-10-11 | 波士顿科学国际有限公司 | 用于选择性细胞消融的时间多路复用波形 |
| CN110175427B (zh) * | 2019-06-03 | 2023-06-09 | 江西理工大学 | 一种在耦合振子系统中实现非对称振荡死亡的方法 |
| MX2021015378A (es) | 2019-06-12 | 2022-01-24 | Truerelief Llc | Sistema y metodo para suministrar corriente electrica de impulsos al tejido vivo. |
| JP2022538419A (ja) | 2019-06-26 | 2022-09-02 | ニューロスティム テクノロジーズ エルエルシー | 適応回路を備えた非侵襲性神経活性化装置 |
| CN114616026A (zh) * | 2019-09-11 | 2022-06-10 | 艾斯奎尔先进医疗设备有限公司 | 组织的电刺激 |
| US11547855B2 (en) | 2019-10-25 | 2023-01-10 | Medtronic, Inc. | ECAP sensing for high frequency neurostimulation |
| US11931582B2 (en) | 2019-10-25 | 2024-03-19 | Medtronic, Inc. | Managing transient overstimulation based on ECAPs |
| DE19211698T1 (de) | 2019-11-27 | 2021-09-02 | Onward Medical B.V. | Neuromodulation system |
| US20230012949A1 (en) * | 2019-12-10 | 2023-01-19 | Activcell Group Ag | Therapeutic device for cell therapy or cell stimulation |
| KR20220115802A (ko) | 2019-12-16 | 2022-08-18 | 뉴로스팀 테크놀로지스 엘엘씨 | 부스트 전하 전달 기능이 있는 비침습적 신경 액티베이터 |
| US11779387B2 (en) | 2019-12-30 | 2023-10-10 | Cilag Gmbh International | Clamp arm jaw to minimize tissue sticking and improve tissue control |
| US11684412B2 (en) | 2019-12-30 | 2023-06-27 | Cilag Gmbh International | Surgical instrument with rotatable and articulatable surgical end effector |
| US12082808B2 (en) | 2019-12-30 | 2024-09-10 | Cilag Gmbh International | Surgical instrument comprising a control system responsive to software configurations |
| US11452525B2 (en) | 2019-12-30 | 2022-09-27 | Cilag Gmbh International | Surgical instrument comprising an adjustment system |
| US12114912B2 (en) | 2019-12-30 | 2024-10-15 | Cilag Gmbh International | Non-biased deflectable electrode to minimize contact between ultrasonic blade and electrode |
| US12053224B2 (en) | 2019-12-30 | 2024-08-06 | Cilag Gmbh International | Variation in electrode parameters and deflectable electrode to modify energy density and tissue interaction |
| US12076006B2 (en) | 2019-12-30 | 2024-09-03 | Cilag Gmbh International | Surgical instrument comprising an orientation detection system |
| US11911063B2 (en) | 2019-12-30 | 2024-02-27 | Cilag Gmbh International | Techniques for detecting ultrasonic blade to electrode contact and reducing power to ultrasonic blade |
| US11660089B2 (en) | 2019-12-30 | 2023-05-30 | Cilag Gmbh International | Surgical instrument comprising a sensing system |
| US11986201B2 (en) | 2019-12-30 | 2024-05-21 | Cilag Gmbh International | Method for operating a surgical instrument |
| US12064109B2 (en) | 2019-12-30 | 2024-08-20 | Cilag Gmbh International | Surgical instrument comprising a feedback control circuit |
| US20210196363A1 (en) | 2019-12-30 | 2021-07-01 | Ethicon Llc | Electrosurgical instrument with electrodes operable in bipolar and monopolar modes |
| US11696776B2 (en) | 2019-12-30 | 2023-07-11 | Cilag Gmbh International | Articulatable surgical instrument |
| US20210196362A1 (en) | 2019-12-30 | 2021-07-01 | Ethicon Llc | Electrosurgical end effectors with thermally insulative and thermally conductive portions |
| US11944366B2 (en) | 2019-12-30 | 2024-04-02 | Cilag Gmbh International | Asymmetric segmented ultrasonic support pad for cooperative engagement with a movable RF electrode |
| US11812957B2 (en) | 2019-12-30 | 2023-11-14 | Cilag Gmbh International | Surgical instrument comprising a signal interference resolution system |
| US11937863B2 (en) | 2019-12-30 | 2024-03-26 | Cilag Gmbh International | Deflectable electrode with variable compression bias along the length of the deflectable electrode |
| US11786291B2 (en) | 2019-12-30 | 2023-10-17 | Cilag Gmbh International | Deflectable support of RF energy electrode with respect to opposing ultrasonic blade |
| US11986234B2 (en) | 2019-12-30 | 2024-05-21 | Cilag Gmbh International | Surgical system communication pathways |
| US11950797B2 (en) | 2019-12-30 | 2024-04-09 | Cilag Gmbh International | Deflectable electrode with higher distal bias relative to proximal bias |
| US11779329B2 (en) | 2019-12-30 | 2023-10-10 | Cilag Gmbh International | Surgical instrument comprising a flex circuit including a sensor system |
| US11974801B2 (en) | 2019-12-30 | 2024-05-07 | Cilag Gmbh International | Electrosurgical instrument with flexible wiring assemblies |
| US12023086B2 (en) | 2019-12-30 | 2024-07-02 | Cilag Gmbh International | Electrosurgical instrument for delivering blended energy modalities to tissue |
| RU2727587C1 (ru) * | 2020-02-05 | 2020-07-22 | Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр реабилитации и курортологии» Министерства здравоохранения Российской Федерации (ФГБУ «НМИЦ РК» Минздрава России) | Способ стимуляции мышц тазового дна методом электробальнеотерапии |
| US12128235B2 (en) | 2020-03-06 | 2024-10-29 | Medtronic, Inc. | Controlling electrical stimulation based on a sensed stimulation signal |
| KR20210123615A (ko) | 2020-04-03 | 2021-10-14 | 박진호 | 혈당측정 기능이 부설된 체외 전기자극을 이용한 통증완화시스템 |
| JP2023525077A (ja) * | 2020-05-07 | 2023-06-14 | バンキッシュ、イノベーション、アンパルトゼルスカブ | 傷の電気治療のための装置及び方法 |
| US12097373B2 (en) | 2020-06-10 | 2024-09-24 | Medtronic, Inc. | Control policy settings for electrical stimulation therapy |
| US11857793B2 (en) | 2020-06-10 | 2024-01-02 | Medtronic, Inc. | Managing storage of sensed information |
| US11707626B2 (en) | 2020-09-02 | 2023-07-25 | Medtronic, Inc. | Analyzing ECAP signals |
| US11896828B2 (en) | 2020-10-30 | 2024-02-13 | Medtronic, Inc. | Implantable lead location using ECAP |
| JP7453130B2 (ja) * | 2020-11-26 | 2024-03-19 | 株式会社モリタ製作所 | 歯科用治療装置 |
| US11426574B1 (en) | 2021-02-05 | 2022-08-30 | Theragen, Inc. | Systems, methods and devices for electrical stimulation therapy |
| US11911605B2 (en) | 2021-03-05 | 2024-02-27 | Truerelief Llc | Method and apparatus for injury treatment |
| KR102700424B1 (ko) * | 2021-11-01 | 2024-08-28 | 서울대학교산학협력단 | 넥밴드형 세균 및 바이러스성 질병 관리 장치 |
| FR3132226A1 (fr) * | 2022-02-03 | 2023-08-04 | Winback Group | Dispositif d'électrothérapie associant l'électrostimulation et la técarthérapie |
| WO2023150215A1 (en) * | 2022-02-03 | 2023-08-10 | CRC EP, Inc. | Systems and methods for pulsed-field ablation with charge-balanced waveforms |
| JP7422810B2 (ja) * | 2022-05-30 | 2024-01-26 | キッコーマン株式会社 | 経皮通電パッチ |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1129142A (en) * | 1965-05-26 | 1968-10-02 | Medical And Biolog Instrumenta | A circuit arrangement for an electric muscle stimulator |
| US3294092A (en) * | 1965-09-13 | 1966-12-27 | Fred S Landauer | Therapeutic apparatus |
| US3589370A (en) * | 1967-06-09 | 1971-06-29 | Medical Biolog Instrumentation | Electronic muscle stimulator |
| US4026304A (en) * | 1972-04-12 | 1977-05-31 | Hydro Med Sciences Inc. | Bone generating method and device |
| GB1459397A (en) * | 1973-03-22 | 1976-12-22 | Biopulse Co Ltd | Apparatus for treating organisms by applying an electrical signal thereto |
| JPS54119792A (en) * | 1978-03-03 | 1979-09-17 | Iriyou Kougaku Kenkiyuushiyo K | Electric stimulation device for removing pain |
| CA1172366A (en) * | 1978-04-04 | 1984-08-07 | Harold W. Gosling | Methods and apparatus for encoding and constructing signals |
| US4255790A (en) * | 1978-09-25 | 1981-03-10 | Hondeghem Luc M | Programmable pulse generating system |
| US4431000A (en) * | 1978-11-29 | 1984-02-14 | Gatron Corporation | Transcutaneous nerve stimulator with pseusorandom pulse generator |
| US4340063A (en) * | 1980-01-02 | 1982-07-20 | Empi, Inc. | Stimulation device |
| US4580570A (en) | 1981-01-08 | 1986-04-08 | Chattanooga Corporation | Electrical therapeutic apparatus |
| US4612934A (en) * | 1981-06-30 | 1986-09-23 | Borkan William N | Non-invasive multiprogrammable tissue stimulator |
| US4580370A (en) * | 1982-11-30 | 1986-04-08 | Energy Adaptive Grinding, Inc. | Centerless and center-type grinding systems |
| CA1215128A (en) * | 1982-12-08 | 1986-12-09 | Pedro Molina-Negro | Electric nerve stimulator device |
| US4784142A (en) * | 1984-01-09 | 1988-11-15 | Pain Suppression Labs, Inc. | Methodology for electronic dental analgesia |
| US4607639A (en) * | 1984-05-18 | 1986-08-26 | Regents Of The University Of California | Method and system for controlling bladder evacuation |
| AU569636B2 (en) * | 1984-09-07 | 1988-02-11 | University Of Melbourne, The | Bipolar paired pulse supplied prosthetic device |
| US4600010A (en) * | 1984-10-04 | 1986-07-15 | Biolectron, Inc. | Electric stimulator and test instrument therefor |
| US4592359A (en) * | 1985-04-02 | 1986-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Multi-channel implantable neural stimulator |
| CA1278045C (en) * | 1985-05-15 | 1990-12-18 | Wu Dumin | Apparatus and method for generating vital information signals |
| US4754759A (en) * | 1985-07-03 | 1988-07-05 | Andromeda Research, Inc. | Neural conduction accelerator and method of application |
| US5031614A (en) * | 1986-09-12 | 1991-07-16 | Eckhard Alt | Pacemaker rate control using amplitude and frequency of activity signal |
| US5117826A (en) * | 1987-02-02 | 1992-06-02 | Staodyn, Inc. | Combined nerve fiber and body tissue stimulation apparatus and method |
| JPH064096B2 (ja) * | 1987-03-25 | 1994-01-19 | 株式会社アドバンス | 皮膚貼着型低周波治療器 |
| US4846181A (en) * | 1987-10-02 | 1989-07-11 | Staodynamics, Inc. | Soft tissue wound healing therapy utilizing pulsed electrical stimulation |
| US4895154A (en) * | 1988-02-19 | 1990-01-23 | Staodynamics, Inc. | Electronic stimulating device for enhanced healing of soft tissue wounds |
| US4938223A (en) * | 1988-03-28 | 1990-07-03 | T. H. Charters, Inc. | Transcutaneous nerve block device |
| US4924880A (en) * | 1988-11-16 | 1990-05-15 | Sion Technology, Inc. | Dental anesthesia apparatus |
| RU2091089C1 (ru) * | 1989-03-06 | 1997-09-27 | Товарищество с ограниченной ответственностью "ОКБ РИТМ" | Устройство для электростимуляции |
| US5063929A (en) * | 1989-08-25 | 1991-11-12 | Staodyn, Inc. | Electronic stimulating device having timed treatment of varying intensity and method therefor |
| US5097833A (en) * | 1989-09-19 | 1992-03-24 | Campos James M | Transcutaneous electrical nerve and/or muscle stimulator |
| US5067495A (en) * | 1989-09-27 | 1991-11-26 | Brehm Richard L | Electro wave therapy |
| US5851223A (en) * | 1991-05-21 | 1998-12-22 | Medi Consultants, Inc. | Combination non-intrusive analgesic neuroaugmentive system and method triple-modulated gigatens with optional bipolar spike |
| US5109847A (en) * | 1991-05-21 | 1992-05-05 | E.P. Inc. | Non-intrusive analgesic neuroaugmentive apparatus and management system |
| US5217009A (en) * | 1991-07-10 | 1993-06-08 | Kronberg James W | Compact biomedical pulsed signal generator for bone tissue stimulation |
| US5350414A (en) * | 1991-12-10 | 1994-09-27 | Electro Science Technologies, Inc. | Local application microprocessor based nerve and muscle stimulator |
| US5565005A (en) * | 1992-02-20 | 1996-10-15 | Amei Technologies Inc. | Implantable growth tissue stimulator and method operation |
| US5487759A (en) * | 1993-06-14 | 1996-01-30 | Bastyr; Charles A. | Nerve stimulating device and associated support device |
| US5413596A (en) * | 1993-11-29 | 1995-05-09 | The United States Of America As Represented By The United States Department Of Energy | Digital electronic bone growth stimulator |
| WO1995033514A1 (en) * | 1994-06-09 | 1995-12-14 | Magnetic Resonance Therapeutics, Inc. | Electro-therapeutic method |
| US5601608A (en) * | 1995-02-02 | 1997-02-11 | Pacesetter, Inc. | Methods and apparatus for applying charge-balanced antiarrhythmia shocks |
| US6865423B2 (en) * | 1996-06-13 | 2005-03-08 | The Victoria University Of Manchester | Stimulation of muscles |
| CA2257926C (en) | 1996-06-13 | 2006-04-04 | The Victoria University Of Manchester | Stimulation of muscles |
| US6011994A (en) * | 1997-09-24 | 2000-01-04 | Equitech Intl' Corporation | Multipurpose biomedical pulsed signal generator |
| US6321119B1 (en) * | 1997-09-24 | 2001-11-20 | Healthonics, Inc. | Pulsed signal generator for bioelectric stimulation and healing acceleration |
| WO1999020341A1 (en) * | 1997-10-16 | 1999-04-29 | Electrologic Of America, Inc. | Electrical stimulation therapy method and apparatus |
| JP2001293097A (ja) * | 2000-04-17 | 2001-10-23 | Seiji Nochida | 低周波治療装置 |
| US7024247B2 (en) * | 2001-10-15 | 2006-04-04 | Northstar Neuroscience, Inc. | Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures |
| US6505079B1 (en) * | 2000-09-13 | 2003-01-07 | Foster Bio Technology Corp. | Electrical stimulation of tissue for therapeutic and diagnostic purposes |
| US6701190B2 (en) * | 2000-10-10 | 2004-03-02 | Meagan Medical, Inc. | System and method for varying characteristics of electrical therapy |
| US6535767B1 (en) * | 2001-08-21 | 2003-03-18 | James W. Kronberg | Apparatus and method for bioelectric stimulation, healing acceleration and pain relief |
| US7483748B2 (en) * | 2002-04-26 | 2009-01-27 | Medtronic, Inc. | Programmable waveform pulses for an implantable medical device |
-
2004
- 2004-06-24 CA CA2876835A patent/CA2876835C/en not_active Expired - Fee Related
- 2004-06-24 EA EA200600093A patent/EA200600093A1/ru unknown
- 2004-06-24 WO PCT/US2004/020207 patent/WO2005002663A2/en active Application Filing
- 2004-06-24 JP JP2006517598A patent/JP4980713B2/ja not_active Expired - Fee Related
- 2004-06-24 US US10/875,801 patent/US7117034B2/en not_active Expired - Lifetime
- 2004-06-24 EP EP04755993.5A patent/EP1648553A4/en not_active Ceased
- 2004-06-24 MX MXPA05014141A patent/MXPA05014141A/es active IP Right Grant
- 2004-06-24 CA CA2530396A patent/CA2530396C/en not_active Expired - Fee Related
- 2004-06-24 TW TW093118333A patent/TWI306407B/zh not_active IP Right Cessation
- 2004-06-24 AU AU2004253501A patent/AU2004253501B2/en not_active Ceased
- 2004-06-24 CN CN2004800243258A patent/CN1842356B/zh not_active Expired - Fee Related
- 2004-06-24 BR BRPI0411817-0A patent/BRPI0411817A/pt not_active Application Discontinuation
- 2004-06-24 KR KR1020057024802A patent/KR101134242B1/ko active IP Right Grant
- 2004-06-25 AR ARP040102239A patent/AR044915A1/es unknown
-
2005
- 2005-12-21 IL IL172726A patent/IL172726A/en unknown
-
2006
- 2006-01-02 CR CR8170A patent/CR8170A/es not_active Application Discontinuation
- 2006-01-23 ZA ZA200600654A patent/ZA200600654B/en unknown
-
2007
- 2007-02-23 HK HK07102036.5A patent/HK1096882A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TW200513282A (en) | 2005-04-16 |
| AU2004253501A1 (en) | 2005-01-13 |
| CA2530396A1 (en) | 2005-01-13 |
| EA200600093A1 (ru) | 2006-08-25 |
| EP1648553A4 (en) | 2017-05-31 |
| IL172726A0 (en) | 2006-04-10 |
| EP1648553A2 (en) | 2006-04-26 |
| HK1096882A1 (en) | 2007-06-15 |
| KR20060033737A (ko) | 2006-04-19 |
| MXPA05014141A (es) | 2006-03-09 |
| CN1842356B (zh) | 2011-05-04 |
| WO2005002663A2 (en) | 2005-01-13 |
| US7117034B2 (en) | 2006-10-03 |
| IL172726A (en) | 2010-11-30 |
| KR101134242B1 (ko) | 2012-04-09 |
| CN1842356A (zh) | 2006-10-04 |
| CA2530396C (en) | 2015-03-24 |
| AU2004253501B2 (en) | 2011-10-20 |
| TWI306407B (en) | 2009-02-21 |
| WO2005002663A3 (en) | 2005-08-18 |
| JP2007524459A (ja) | 2007-08-30 |
| US20040267333A1 (en) | 2004-12-30 |
| CA2876835A1 (en) | 2005-01-13 |
| CR8170A (es) | 2006-06-01 |
| AR044915A1 (es) | 2005-10-12 |
| JP4980713B2 (ja) | 2012-07-18 |
| BRPI0411817A (pt) | 2006-05-23 |
| CA2876835C (en) | 2020-06-30 |
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