ZA200508828B - Diphenylurea derivatives and their use as a chloride channel blockers - Google Patents
Diphenylurea derivatives and their use as a chloride channel blockers Download PDFInfo
- Publication number
- ZA200508828B ZA200508828B ZA200508828A ZA200508828A ZA200508828B ZA 200508828 B ZA200508828 B ZA 200508828B ZA 200508828 A ZA200508828 A ZA 200508828A ZA 200508828 A ZA200508828 A ZA 200508828A ZA 200508828 B ZA200508828 B ZA 200508828B
- Authority
- ZA
- South Africa
- Prior art keywords
- tetrazol
- urea
- phenyl
- biphenyl
- trifluoromethyl
- Prior art date
Links
- 108010062745 Chloride Channels Proteins 0.000 title claims description 13
- 102000011045 Chloride Channels Human genes 0.000 title claims description 13
- GWEHVDNNLFDJLR-UHFFFAOYSA-N 1,3-diphenylurea Chemical class C=1C=CC=CC=1NC(=O)NC1=CC=CC=C1 GWEHVDNNLFDJLR-UHFFFAOYSA-N 0.000 title description 4
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- 150000001875 compounds Chemical class 0.000 claims description 70
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 28
- 150000003839 salts Chemical class 0.000 claims description 27
- 239000001257 hydrogen Substances 0.000 claims description 25
- 229910052739 hydrogen Inorganic materials 0.000 claims description 25
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 23
- 125000000217 alkyl group Chemical group 0.000 claims description 22
- -1 triflucromethoxy Chemical group 0.000 claims description 22
- 125000003545 alkoxy group Chemical group 0.000 claims description 21
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- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 15
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- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
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- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
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- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
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- 239000011591 potassium Substances 0.000 description 1
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- 239000001103 potassium chloride Substances 0.000 description 1
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- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- ALDITMKAAPLVJK-UHFFFAOYSA-N prop-1-ene;hydrate Chemical group O.CC=C ALDITMKAAPLVJK-UHFFFAOYSA-N 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Substances CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
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- 229920005989 resin Polymers 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 210000002363 skeletal muscle cell Anatomy 0.000 description 1
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- 235000015424 sodium Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
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- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
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- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
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- 125000001424 substituent group Chemical group 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- 230000008719 thickening Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
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- GTZCVFVGUGFEME-UHFFFAOYSA-N trans-aconitic acid Natural products OC(=O)CC(C(O)=O)=CC(O)=O GTZCVFVGUGFEME-UHFFFAOYSA-N 0.000 description 1
- 150000004684 trihydrates Chemical class 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200300898 | 2003-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200508828B true ZA200508828B (en) | 2008-01-30 |
Family
ID=33547538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200508828A ZA200508828B (en) | 2003-06-17 | 2004-06-15 | Diphenylurea derivatives and their use as a chloride channel blockers |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7691891B2 (ru) |
| EP (1) | EP1638948B1 (ru) |
| JP (1) | JP2006527735A (ru) |
| KR (1) | KR20060059901A (ru) |
| CN (1) | CN1805942B (ru) |
| AT (1) | ATE411301T1 (ru) |
| AU (1) | AU2004247429B2 (ru) |
| BR (1) | BRPI0410576A (ru) |
| CA (1) | CA2529806A1 (ru) |
| DE (1) | DE602004017175D1 (ru) |
| DK (1) | DK1638948T3 (ru) |
| HK (1) | HK1091816A1 (ru) |
| IS (1) | IS8211A (ru) |
| MX (1) | MXPA05013269A (ru) |
| NO (1) | NO20060231L (ru) |
| NZ (1) | NZ543595A (ru) |
| RU (1) | RU2350607C2 (ru) |
| UA (1) | UA81664C2 (ru) |
| WO (1) | WO2004111017A1 (ru) |
| ZA (1) | ZA200508828B (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2591616A1 (en) * | 2004-12-17 | 2006-06-22 | Neurosearch A/S | Diphenylurea derivatives useful as potassium channel activators |
| JP2009530238A (ja) * | 2006-03-14 | 2009-08-27 | ノイロサーチ アクティーゼルスカブ | ジフェニル尿素誘導体及び塩化物チャネル遮断薬又はＢＫＣａチャネル調節薬としてのその使用 |
| US20100292283A1 (en) * | 2007-11-28 | 2010-11-18 | Antonio Nardi | Novel phenyl-acetamide and phenyl-propionamide derivatives useful as potassium channel modulators |
| US9834537B2 (en) | 2013-11-27 | 2017-12-05 | Korea Institute Of Science And Technology | Compounds as chloride channel blocking agent |
| LT3622953T (lt) * | 2016-05-17 | 2021-04-26 | Scandion Oncology A/S | Kombinuotas vėžio gydymas |
| CN117229258A (zh) * | 2022-06-07 | 2023-12-15 | 杭州壹瑞医药科技有限公司 | N-四唑基芳基脲类衍生物及其制备方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0906273B1 (en) * | 1996-05-24 | 2002-10-16 | Neurosearch A/S | Phenyl derivatives containing an acidic group, their preparation and their use as chloride channel blockers |
| US6297261B1 (en) | 1997-04-22 | 2001-10-02 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
| US6696475B2 (en) * | 1997-04-22 | 2004-02-24 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
| JP2002526522A (ja) | 1998-10-02 | 2002-08-20 | ニューロサーチ、アクティーゼルスカブ | ジアミノシクロブテン−３，４−ジオン誘導体、その製造方法及びその使用方法 |
| NZ510098A (en) | 1998-10-22 | 2003-09-26 | Neurosearch As | Substituted phenyl derivatives, pharmaceuticals thereof and their use as blockers of the chloride channel |
| AU2002223492A1 (en) * | 2000-11-14 | 2002-05-27 | Neurosearch A/S | Use of malaria parasite anion channel blockers for treating malaria |
| US20050080112A1 (en) * | 2001-06-22 | 2005-04-14 | Madsen Lars Siim | Compounds for use in disorders associated with mast cell or basophil acitvity |
| JP2005537336A (ja) * | 2002-08-01 | 2005-12-08 | ニューロサーチ、アクティーゼルスカブ | 抗血管新生治療に応答する疾患の治療に有用な化合物 |
| ATE435199T1 (de) * | 2002-09-05 | 2009-07-15 | Neurosearch As | Diarylharnstoffderivate und deren verwendung als chloridkanalblocker |
| CA2591616A1 (en) * | 2004-12-17 | 2006-06-22 | Neurosearch A/S | Diphenylurea derivatives useful as potassium channel activators |
-
2004
- 2004-06-15 DK DK04741799T patent/DK1638948T3/da active
- 2004-06-15 CN CN2004800168685A patent/CN1805942B/zh not_active Expired - Fee Related
- 2004-06-15 MX MXPA05013269A patent/MXPA05013269A/es active IP Right Grant
- 2004-06-15 EP EP04741799A patent/EP1638948B1/en active Active
- 2004-06-15 CA CA002529806A patent/CA2529806A1/en not_active Abandoned
- 2004-06-15 AU AU2004247429A patent/AU2004247429B2/en not_active Ceased
- 2004-06-15 RU RU2005136532/04A patent/RU2350607C2/ru not_active IP Right Cessation
- 2004-06-15 NZ NZ543595A patent/NZ543595A/en unknown
- 2004-06-15 BR BRPI0410576-1A patent/BRPI0410576A/pt not_active IP Right Cessation
- 2004-06-15 US US10/561,189 patent/US7691891B2/en not_active Expired - Fee Related
- 2004-06-15 ZA ZA200508828A patent/ZA200508828B/en unknown
- 2004-06-15 WO PCT/EP2004/051111 patent/WO2004111017A1/en active Application Filing
- 2004-06-15 JP JP2006516151A patent/JP2006527735A/ja active Pending
- 2004-06-15 UA UAA200510477A patent/UA81664C2/ru unknown
- 2004-06-15 DE DE602004017175T patent/DE602004017175D1/de active Active
- 2004-06-15 KR KR1020057024088A patent/KR20060059901A/ko not_active Application Discontinuation
- 2004-06-15 AT AT04741799T patent/ATE411301T1/de not_active IP Right Cessation
-
2005
- 2005-12-30 IS IS8211A patent/IS8211A/is unknown
-
2006
- 2006-01-16 NO NO20060231A patent/NO20060231L/no not_active Application Discontinuation
- 2006-11-08 HK HK06112262.0A patent/HK1091816A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006527735A (ja) | 2006-12-07 |
| NO20060231L (no) | 2006-01-16 |
| CN1805942B (zh) | 2010-06-02 |
| WO2004111017A1 (en) | 2004-12-23 |
| AU2004247429B2 (en) | 2010-01-28 |
| DE602004017175D1 (de) | 2008-11-27 |
| BRPI0410576A (pt) | 2006-06-20 |
| CA2529806A1 (en) | 2004-12-23 |
| AU2004247429A1 (en) | 2004-12-23 |
| EP1638948B1 (en) | 2008-10-15 |
| CN1805942A (zh) | 2006-07-19 |
| NZ543595A (en) | 2009-01-31 |
| DK1638948T3 (da) | 2009-02-02 |
| HK1091816A1 (en) | 2007-01-26 |
| KR20060059901A (ko) | 2006-06-02 |
| UA81664C2 (ru) | 2008-01-25 |
| RU2350607C2 (ru) | 2009-03-27 |
| ATE411301T1 (de) | 2008-10-15 |
| IS8211A (is) | 2005-12-30 |
| US20060178413A1 (en) | 2006-08-10 |
| US7691891B2 (en) | 2010-04-06 |
| EP1638948A1 (en) | 2006-03-29 |
| RU2005136532A (ru) | 2006-07-27 |
| MXPA05013269A (es) | 2006-03-17 |
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