DE602004017175D1 - Diphenylurea-derivative und ihre verwendung als chloridkanalblocker - Google Patents
Diphenylurea-derivative und ihre verwendung als chloridkanalblockerInfo
- Publication number
- DE602004017175D1 DE602004017175D1 DE602004017175T DE602004017175T DE602004017175D1 DE 602004017175 D1 DE602004017175 D1 DE 602004017175D1 DE 602004017175 T DE602004017175 T DE 602004017175T DE 602004017175 T DE602004017175 T DE 602004017175T DE 602004017175 D1 DE602004017175 D1 DE 602004017175D1
- Authority
- DE
- Germany
- Prior art keywords
- channel blockers
- chloride channel
- diphenylurea derivatives
- diphenylurea
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- GWEHVDNNLFDJLR-UHFFFAOYSA-N 1,3-diphenylurea Chemical class C=1C=CC=CC=1NC(=O)NC1=CC=CC=C1 GWEHVDNNLFDJLR-UHFFFAOYSA-N 0.000 title abstract 2
- 108010062745 Chloride Channels Proteins 0.000 title abstract 2
- 102000011045 Chloride Channels Human genes 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200300898 | 2003-06-17 | ||
| PCT/EP2004/051111 WO2004111017A1 (en) | 2003-06-17 | 2004-06-15 | Diphenylurea derivatives and their use as chloride channel blockers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004017175D1 true DE602004017175D1 (de) | 2008-11-27 |
Family
ID=33547538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004017175T Expired - Lifetime DE602004017175D1 (de) | 2003-06-17 | 2004-06-15 | Diphenylurea-derivative und ihre verwendung als chloridkanalblocker |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7691891B2 (de) |
| EP (1) | EP1638948B1 (de) |
| JP (1) | JP2006527735A (de) |
| KR (1) | KR20060059901A (de) |
| CN (1) | CN1805942B (de) |
| AT (1) | ATE411301T1 (de) |
| AU (1) | AU2004247429B2 (de) |
| BR (1) | BRPI0410576A (de) |
| CA (1) | CA2529806A1 (de) |
| DE (1) | DE602004017175D1 (de) |
| DK (1) | DK1638948T3 (de) |
| HK (1) | HK1091816A1 (de) |
| IS (1) | IS8211A (de) |
| MX (1) | MXPA05013269A (de) |
| NO (1) | NO20060231L (de) |
| NZ (1) | NZ543595A (de) |
| RU (1) | RU2350607C2 (de) |
| UA (1) | UA81664C2 (de) |
| WO (1) | WO2004111017A1 (de) |
| ZA (1) | ZA200508828B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005315607A1 (en) * | 2004-12-17 | 2006-06-22 | Neurosearch A/S | Diphenylurea derivatives useful as potassium channel activators |
| JP2009530238A (ja) | 2006-03-14 | 2009-08-27 | ノイロサーチ アクティーゼルスカブ | ジフェニル尿素誘導体及び塩化物チャネル遮断薬又はＢＫＣａチャネル調節薬としてのその使用 |
| WO2009068557A1 (en) * | 2007-11-28 | 2009-06-04 | Neurosearch A/S | Novel phenyl-acetamide and phenyl-propionamide derivatives useful as potassium channel modulators |
| US9834537B2 (en) | 2013-11-27 | 2017-12-05 | Korea Institute Of Science And Technology | Compounds as chloride channel blocking agent |
| US11103481B2 (en) * | 2016-05-17 | 2021-08-31 | Scandion Oncology A/S | Combination treatment of cancer |
| CN117229258A (zh) * | 2022-06-07 | 2023-12-15 | 杭州壹瑞医药科技有限公司 | N-四唑基芳基脲类衍生物及其制备方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4073489B2 (ja) * | 1996-05-24 | 2008-04-09 | ニューロサーチ・アクティーゼルスカブ | 酸性基を有するフエニル誘導体、その製造方法及びそれをクロライドチャンネル遮断剤として使用する方法 |
| CN1118462C (zh) | 1997-04-22 | 2003-08-20 | 神经研究公司 | 取代的苯基衍生物、其制备方法以及用途 |
| US6696475B2 (en) * | 1997-04-22 | 2004-02-24 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
| EP1117633B1 (de) | 1998-10-02 | 2002-09-18 | Neurosearch A/S | Diaminocyclobuten-3,4-dionderivate, deren herstellung und deren verwendung |
| CA2342626A1 (en) * | 1998-10-22 | 2000-05-04 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
| AU2002223492A1 (en) * | 2000-11-14 | 2002-05-27 | Neurosearch A/S | Use of malaria parasite anion channel blockers for treating malaria |
| US20050080112A1 (en) * | 2001-06-22 | 2005-04-14 | Madsen Lars Siim | Compounds for use in disorders associated with mast cell or basophil acitvity |
| NZ537809A (en) * | 2002-08-01 | 2007-05-31 | Neurosearch As | 1-H-tetrazol-5-yl(phenyl) urea derivative compounds useful for the treatment of diseases responsive to antiangiogenetic therapy |
| WO2004022529A2 (en) * | 2002-09-05 | 2004-03-18 | Neurosearch A/S | Diarylurea derivatives and their use as chloride channel blockers |
| AU2005315607A1 (en) * | 2004-12-17 | 2006-06-22 | Neurosearch A/S | Diphenylurea derivatives useful as potassium channel activators |
-
2004
- 2004-06-15 AT AT04741799T patent/ATE411301T1/de not_active IP Right Cessation
- 2004-06-15 NZ NZ543595A patent/NZ543595A/en unknown
- 2004-06-15 UA UAA200510477A patent/UA81664C2/ru unknown
- 2004-06-15 WO PCT/EP2004/051111 patent/WO2004111017A1/en active Application Filing
- 2004-06-15 DE DE602004017175T patent/DE602004017175D1/de not_active Expired - Lifetime
- 2004-06-15 ZA ZA200508828A patent/ZA200508828B/en unknown
- 2004-06-15 BR BRPI0410576-1A patent/BRPI0410576A/pt not_active IP Right Cessation
- 2004-06-15 JP JP2006516151A patent/JP2006527735A/ja active Pending
- 2004-06-15 KR KR1020057024088A patent/KR20060059901A/ko not_active Application Discontinuation
- 2004-06-15 EP EP04741799A patent/EP1638948B1/de not_active Expired - Lifetime
- 2004-06-15 MX MXPA05013269A patent/MXPA05013269A/es active IP Right Grant
- 2004-06-15 RU RU2005136532/04A patent/RU2350607C2/ru not_active IP Right Cessation
- 2004-06-15 AU AU2004247429A patent/AU2004247429B2/en not_active Ceased
- 2004-06-15 US US10/561,189 patent/US7691891B2/en not_active Expired - Fee Related
- 2004-06-15 CA CA002529806A patent/CA2529806A1/en not_active Abandoned
- 2004-06-15 CN CN2004800168685A patent/CN1805942B/zh not_active Expired - Fee Related
- 2004-06-15 DK DK04741799T patent/DK1638948T3/da active
-
2005
- 2005-12-30 IS IS8211A patent/IS8211A/is unknown
-
2006
- 2006-01-16 NO NO20060231A patent/NO20060231L/no not_active Application Discontinuation
- 2006-11-08 HK HK06112262.0A patent/HK1091816A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200508828B (en) | 2008-01-30 |
| BRPI0410576A (pt) | 2006-06-20 |
| CN1805942A (zh) | 2006-07-19 |
| EP1638948A1 (de) | 2006-03-29 |
| RU2350607C2 (ru) | 2009-03-27 |
| HK1091816A1 (en) | 2007-01-26 |
| EP1638948B1 (de) | 2008-10-15 |
| AU2004247429A1 (en) | 2004-12-23 |
| US7691891B2 (en) | 2010-04-06 |
| CN1805942B (zh) | 2010-06-02 |
| KR20060059901A (ko) | 2006-06-02 |
| IS8211A (is) | 2005-12-30 |
| JP2006527735A (ja) | 2006-12-07 |
| RU2005136532A (ru) | 2006-07-27 |
| US20060178413A1 (en) | 2006-08-10 |
| NZ543595A (en) | 2009-01-31 |
| UA81664C2 (ru) | 2008-01-25 |
| DK1638948T3 (da) | 2009-02-02 |
| WO2004111017A1 (en) | 2004-12-23 |
| AU2004247429B2 (en) | 2010-01-28 |
| MXPA05013269A (es) | 2006-03-17 |
| NO20060231L (no) | 2006-01-16 |
| ATE411301T1 (de) | 2008-10-15 |
| CA2529806A1 (en) | 2004-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |