ZA200505860B - Compositions comprising fatty acids and amino acids - Google Patents
Compositions comprising fatty acids and amino acids Download PDFInfo
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- ZA200505860B ZA200505860B ZA200505860A ZA200505860A ZA200505860B ZA 200505860 B ZA200505860 B ZA 200505860B ZA 200505860 A ZA200505860 A ZA 200505860A ZA 200505860 A ZA200505860 A ZA 200505860A ZA 200505860 B ZA200505860 B ZA 200505860B
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Landscapes
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Applications Claiming Priority (1)
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US45545303P | 2003-03-18 | 2003-03-18 |
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ZA200505860A ZA200505860B (en) | 2003-03-18 | 2006-02-09 | Compositions comprising fatty acids and amino acids |
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US (1) | US20060159746A1 (fr) |
EP (1) | EP1605781A1 (fr) |
JP (1) | JP2006520335A (fr) |
CN (1) | CN100415224C (fr) |
AU (1) | AU2004222633B2 (fr) |
BR (1) | BRPI0408490A (fr) |
CA (1) | CA2516142A1 (fr) |
MX (1) | MXPA05009933A (fr) |
NZ (1) | NZ541516A (fr) |
PL (1) | PL377614A1 (fr) |
RU (1) | RU2356247C2 (fr) |
WO (1) | WO2004082402A1 (fr) |
ZA (1) | ZA200505860B (fr) |
Families Citing this family (119)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7223434B2 (en) | 2001-11-21 | 2007-05-29 | Gerber Products Company | Blended baby foods |
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
MXPA06004698A (es) * | 2003-10-27 | 2006-07-05 | Innodia Inc | Metodos y composiciones para utilizarse en el tratamiento de la diabetes. |
WO2005049006A1 (fr) * | 2003-11-21 | 2005-06-02 | Ajinomoto Co., Inc. | Remede contre les diabetes |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
CN101027318B (zh) | 2004-07-19 | 2016-05-25 | 比奥孔有限公司 | 胰岛素-低聚物共轭物,制剂及其用途 |
WO2006017627A2 (fr) * | 2004-08-06 | 2006-02-16 | Barry Sears | Compositions dietetiques et procedes d'utilisation dans le traitement de l'insulinoresistance |
US20060083824A1 (en) * | 2004-10-20 | 2006-04-20 | Pbm Products Llc | Nutritional supplements for glucose intolerant individuals |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
ES2402935T3 (es) | 2005-03-21 | 2013-05-10 | Abbott Laboratories | Composición de aminoácidos para mejorar la tolerancia a la glucosa |
DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
US20070077310A1 (en) * | 2005-10-03 | 2007-04-05 | University Of Tennessee Research Foundation | Methods of reducing the production of reactive oxygen species and methods of screening or identifying compounds and compositions that reduce the production of reactive oxygen species |
EP1951071A2 (fr) * | 2005-10-18 | 2008-08-06 | Artmed S.r.l. | Compositions nutraceutiques et pharmaceutiques contenant de la choline et pouvant servir d'adjuvants dans la prevention et le traitement des retinopathies et du glaucome |
FR2892894B1 (fr) * | 2005-11-08 | 2008-01-11 | Juva Soc Par Actions Simplifie | Complement alimentaire comprenant de la phaseolamine. |
DE102006001035A1 (de) * | 2006-01-07 | 2007-07-12 | Beisel, Günther | Mittel für die perorale Applikation zur Verzögerung der Resorption von Stoffen |
FR2896163B1 (fr) * | 2006-01-18 | 2011-04-15 | Ct Hospitalier Universitaire Montpellier | Produit utilise en tant que complement alimentaire ou medicament, destine a reduire la prise de lipides dans l'alimentation, et utilisation de ce produit. |
US8110231B2 (en) | 2006-04-10 | 2012-02-07 | Kraft Foods Global Brands Llc | Methods for making improved texture cereal bars |
EP1852108A1 (fr) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | Compositions d'inhibiteurs de la DPP IV |
EA030606B1 (ru) | 2006-05-04 | 2018-08-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Способы приготовления лекарственного средства, содержащего полиморфы |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
EP2034983A1 (fr) * | 2006-06-27 | 2009-03-18 | Lipid Nutrition B.V. | Emploi d'un composé acide gras polyinsaturé |
US20080171791A1 (en) * | 2007-01-11 | 2008-07-17 | Mdr Fitness Corp. | Compositions and Method for Losing Weight |
NO2106260T3 (fr) | 2007-01-25 | 2018-05-05 | ||
WO2009050738A2 (fr) | 2007-10-16 | 2009-04-23 | Biocon Limited | Composition pharmaceutique solide administrable par voie orale et procédé associé |
CN105267969A (zh) | 2008-01-04 | 2016-01-27 | 雀巢产品技术援助有限公司 | 包含不饱和脂肪酸和一氧化氮释放化合物的组合物及其用于增强认知和相关功能的用途 |
PE20091730A1 (es) * | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
JPWO2009151116A1 (ja) * | 2008-06-13 | 2011-11-17 | 持田製薬株式会社 | 非アルコール性脂肪肝炎の予防/改善・治療薬 |
WO2010002242A1 (fr) * | 2008-07-02 | 2010-01-07 | N.V. Nutricia | Composition nutritionnelle pour améliorer la fonction musculaire et l'activité quotidienne |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
KR20200118243A (ko) | 2008-08-06 | 2020-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
EP3187182B1 (fr) | 2008-09-02 | 2021-03-03 | Amarin Pharmaceuticals Ireland Limited | Compositions pharmaceutiques contenant de l'acide eicosapentaénoïque et de l'acide nicotinique, et leurs procédés d'utilisation |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
ES2745849T3 (es) * | 2008-12-05 | 2020-03-03 | Ajinomoto Kk | Composición nutricional |
JP2012512848A (ja) | 2008-12-23 | 2012-06-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 有機化合物の塩の形態 |
AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
BRPI1007518A2 (pt) | 2009-02-10 | 2018-02-20 | Amarin Pharma, Inc. | uso de acido etil ester eicopentanoico para tratamento de hipertrigliceridemia |
AU2016203375B2 (en) * | 2009-04-29 | 2017-11-30 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
EP2424521A4 (fr) | 2009-04-29 | 2015-03-04 | Amarin Pharmaceuticals Ie Ltd | Compositions pharmaceutiques comprenant de l'epa et un agent cardiovasculaire et leurs procédés d'utilisation |
AU2014200070B2 (en) * | 2009-04-29 | 2016-06-16 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
BRPI1011876B1 (pt) | 2009-04-29 | 2020-03-31 | Amarin Pharma, Inc. | Composições farmacêuticas estáveis compreendendo etilácido eicosapentaenoico (etil-epa) e uso das mesmas para tratar ou prevenir uma doença relacionada ao cardiovascular |
WO2010137944A1 (fr) | 2009-05-27 | 2010-12-02 | N.V. Nutricia | Traitement de l'hypercalcémie |
GB0909643D0 (en) | 2009-06-04 | 2009-07-22 | Avexxin As | Glomerulonephritis treatment |
DK2443246T3 (en) | 2009-06-15 | 2018-03-26 | Amarin Pharmaceuticals Ie Ltd | COMPOSITIONS AND METHODS FOR REDUCING TRIGLYCERIDES WITHOUT INCREASING LDL-C LEVELS IN AN INDIVIDUAL WITH CURRENT STATE THERAPY |
RU2012116079A (ru) | 2009-09-23 | 2013-10-27 | АМАРИН КОРПОРЕЙШН ПиЭлСи | Фармацевтическая композиция, включающая омега-3 жирную кислоту и гидроксипроизводное статина и способы ее применения |
CN102596191B (zh) * | 2009-10-02 | 2016-12-21 | 勃林格殷格翰国际有限公司 | 包含bi‑1356和二甲双胍的药物组合物 |
BR112012012641A2 (pt) | 2009-11-27 | 2020-08-11 | Boehringer Ingelheim International Gmbh | TRATAMENTO DE PACIENTES DIABÉTICOS GENOTIPADOS COM INIBIDORES DE DPP-lVTAL COMO LINAGLIPTINA |
NL1037643C2 (en) * | 2010-01-22 | 2011-07-25 | Karel Paul Bouter | Nutritional product comprising a biguanide. |
WO2011138421A1 (fr) | 2010-05-05 | 2011-11-10 | Boehringer Ingelheim International Gmbh | Combinaison thérapeutique |
EP3366304B1 (fr) | 2010-06-24 | 2020-05-13 | Boehringer Ingelheim International GmbH | Traitement du diabète |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
NZ727980A (en) | 2010-11-29 | 2018-08-31 | Amarin Pharmaceuticals Ie Ltd | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
US11712429B2 (en) | 2010-11-29 | 2023-08-01 | Amarin Pharmaceuticals Ireland Limited | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
US20120178813A1 (en) | 2011-01-12 | 2012-07-12 | Thetis Pharmaceuticals Llc | Lipid-lowering antidiabetic agent |
EP3466418A1 (fr) | 2011-07-15 | 2019-04-10 | NuSirt Sciences, Inc. | Compositions et procédés pour moduler les voies métaboliques |
WO2013010964A1 (fr) | 2011-07-15 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Quinazolines substituées, la préparation de celles-ci et l'utilisation de celles-ci dans des compositions pharmaceutiques |
GB2510712A (en) * | 2011-07-22 | 2014-08-13 | Karel Paul Bouter | Nutritional product comprising a biguanide |
US20130131170A1 (en) | 2011-11-07 | 2013-05-23 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
US11291643B2 (en) | 2011-11-07 | 2022-04-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
AU2013207368A1 (en) | 2012-01-06 | 2014-07-24 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering levels of high-sensitivity (hs-CRP) in a subject |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
US9198454B2 (en) | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
WO2013171167A1 (fr) | 2012-05-14 | 2013-11-21 | Boehringer Ingelheim International Gmbh | Dérivé de xanthine en tant qu'inhibiteur de dpp-4 pour l'utilisation dans le traitement de troubles associés aux podocytes et/ou un syndrome néphrotique |
WO2013174767A1 (fr) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | Dérivé de xanthine en tant qu'inhibiteur de la dpp-4 à utiliser dans la modification de l'apport alimentaire et dans la régulation des préférences alimentaires |
RU2664442C2 (ru) * | 2012-05-24 | 2018-08-17 | Найя Метаболик, Инк. | Способ снижения веса |
EP4342546A3 (fr) | 2012-06-29 | 2024-05-22 | Amarin Pharmaceuticals Ireland Limited | Procédés de réduction du risque d'un événement cardiovasculaire chez un sujet soumis à un traitement par une statine |
US9108942B1 (en) | 2014-11-05 | 2015-08-18 | Mahesh Kandula | Compositions and methods for the treatment of moderate to severe pain |
EP2872483A4 (fr) * | 2012-07-10 | 2016-03-16 | Thetis Pharmaceuticals Llc | Forme à trois sels de metformine |
US9382187B2 (en) | 2012-07-10 | 2016-07-05 | Thetis Pharmaceuticals Llc | Tri-salt form of metformin |
US8765811B2 (en) | 2012-07-10 | 2014-07-01 | Thetis Pharmaceuticals Llc | Tri-salt form of metformin |
WO2014043064A1 (fr) * | 2012-09-11 | 2014-03-20 | Jj Robin, Llc | Formulation nutritionnelle pour la régulation du poids |
WO2014074552A2 (fr) | 2012-11-06 | 2014-05-15 | Amarin Pharmaceuticals Ireland Limited | Compositions et procédés pour diminuer les triglycérides sans augmenter les taux de ldl-c chez un sujet traité en même temps par la statine |
BR112015010947A2 (pt) | 2012-11-13 | 2018-06-05 | Nusirt Sciences Inc | composições e métodos para aumentar o metabolismo energético. |
US20140187633A1 (en) | 2012-12-31 | 2014-07-03 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis |
US9814733B2 (en) | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
US9452151B2 (en) | 2013-02-06 | 2016-09-27 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing apolipoprotein C-III |
US8853259B2 (en) * | 2013-02-07 | 2014-10-07 | Banavara L. Mylari | Metformin derivatives for treating diabetes and diabetes complications |
US9624492B2 (en) | 2013-02-13 | 2017-04-18 | Amarin Pharmaceuticals Ireland Limited | Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof |
US9662307B2 (en) | 2013-02-19 | 2017-05-30 | The Regents Of The University Of Colorado | Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof |
US9283201B2 (en) | 2013-03-14 | 2016-03-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for treating or preventing obesity in a subject in need thereof |
BR112015023310A2 (pt) | 2013-03-15 | 2017-07-18 | Nusirt Sciences Inc | composições, métodos e kits para redução de níveis lipídicos |
US20140271841A1 (en) | 2013-03-15 | 2014-09-18 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin |
US9333187B1 (en) | 2013-05-15 | 2016-05-10 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory bowel disease |
CA2914461A1 (fr) * | 2013-06-04 | 2014-12-11 | Cellixbio Private Limited | Compositions et procedes de traitement du diabete et du pre-diabete |
US10966968B2 (en) | 2013-06-06 | 2021-04-06 | Amarin Pharmaceuticals Ireland Limited | Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof |
US20150065572A1 (en) | 2013-09-04 | 2015-03-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing prostate cancer |
US9585859B2 (en) | 2013-10-10 | 2017-03-07 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy |
EP3057451A4 (fr) * | 2013-10-16 | 2017-06-21 | Ensisheim Partners LLC | Formulations spécifiques aux protéines |
US9096537B1 (en) | 2014-12-31 | 2015-08-04 | Mahesh Kandula | Compositions and methods for the treatment of mucositis |
WO2015131152A1 (fr) | 2014-02-27 | 2015-09-03 | Nusirt Sciences Inc. | Compositions et procédés permettant la réduction ou la prévention de stéatose hépatique |
ES2950384T3 (es) | 2014-02-28 | 2023-10-09 | Boehringer Ingelheim Int | Uso médico de un inhibidor de DPP-4 |
WO2015161448A1 (fr) * | 2014-04-22 | 2015-10-29 | Wuhan Ll Science And Technology Development Co., Ltd. | Compositions contenant de l'ornithine ou de l'aspartate et leurs utilisations |
WO2015171516A1 (fr) | 2014-05-05 | 2015-11-12 | Thetis Pharmaceuticals Llc | Compositions et procédés se rapportant à des sels ioniques de peptides |
US10561631B2 (en) | 2014-06-11 | 2020-02-18 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing RLP-C |
US10172818B2 (en) | 2014-06-16 | 2019-01-08 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
KR20170023061A (ko) | 2014-06-18 | 2017-03-02 | 테티스 파마수티컬스 엘엘씨 | 활성제의 미네랄 아미노산 복합체 |
US9242008B2 (en) | 2014-06-18 | 2016-01-26 | Thetis Pharmaceuticals Llc | Mineral amino-acid complexes of fatty acids |
WO2015200842A1 (fr) * | 2014-06-26 | 2015-12-30 | MicroBiome Therapeutics LLC | Composition comprenant de la metformine et un modulateur du microbiome |
CN104152505B (zh) * | 2014-08-08 | 2016-11-23 | 江南大学 | 一种利用重组菌株转化制备4-羟基-l-异亮氨酸的方法 |
WO2016046835A1 (fr) | 2014-09-26 | 2016-03-31 | Cellix Bio Private Limited | Compositions et méthodes de traitement de l'épilepsie et de troubles neurologiques |
CA2967908C (fr) | 2014-09-29 | 2020-11-17 | Mahesh Kandula | Compositions et methodes pour le traitement de la sclerose en plaques |
US9932294B2 (en) | 2014-12-01 | 2018-04-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
SG11201705524SA (en) | 2015-01-06 | 2017-08-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of inflammation and pain |
WO2016132186A1 (fr) * | 2015-02-20 | 2016-08-25 | Mohan M Alapati | Compositions et méthodes de traitement de l'hyperglycémie et du syndrome métabolique |
GB201604316D0 (en) | 2016-03-14 | 2016-04-27 | Avexxin As | Combination therapy |
US10406130B2 (en) | 2016-03-15 | 2019-09-10 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids |
CA3026264A1 (fr) | 2016-06-03 | 2017-12-07 | Thetis Pharmaceuticals Llc | Compositions et procedes relatifs a des sels de mediateurs specialises de pro-resolution d'inflammation |
EP3468562A1 (fr) | 2016-06-10 | 2019-04-17 | Boehringer Ingelheim International GmbH | Combinaisons de linagliptine et de metformine |
JP2019529555A (ja) | 2016-09-21 | 2019-10-17 | アヴェクシン エーエス | 医薬組成物 |
JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
AU2018217906A1 (en) | 2017-02-13 | 2019-08-15 | Wintermute Biomedical, Inc. | Anti-pathogenic therapeutic compositions |
TW201900160A (zh) | 2017-05-19 | 2019-01-01 | 愛爾蘭商艾瑪琳製藥愛爾蘭有限公司 | 用於降低腎功能下降之個體中的三酸甘油酯之組合物及方法 |
EP3668499A1 (fr) | 2017-08-14 | 2020-06-24 | Axcella Health Inc. | Acides aminés à chaîne ramifiée pour le traitement d'une maladie du foie |
US11058661B2 (en) | 2018-03-02 | 2021-07-13 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L |
EP3810123A1 (fr) | 2018-06-20 | 2021-04-28 | Axcella Health Inc. | Compositions et procédés pour le traitement de l'infiltration de graisse dans le muscle |
KR20210110890A (ko) | 2018-09-24 | 2021-09-09 | 애머린 파마슈티칼스 아일랜드 리미티드 | 대상체에서 심혈관 사건의 위험도를 감소시키는 방법 |
KR20210108942A (ko) | 2018-10-01 | 2021-09-03 | 윈터뮤트 바이오메디컬 인코포레이티드 | 치료 조성물 |
US20220233651A1 (en) * | 2019-06-03 | 2022-07-28 | Société des Produits Nestlé S.A. | Recover dietary supplement |
US20230058544A1 (en) * | 2020-02-06 | 2023-02-23 | Dsm Ip Assets B.V. | Method for increasing eicosapentaenoic acid level in the plasma of an animal |
WO2022225896A1 (fr) | 2021-04-21 | 2022-10-27 | Amarin Pharmaceuticals Ireland Limited | Procédés de réduction du risque d'insuffisance cardiaque |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE86108T1 (de) * | 1987-02-20 | 1993-03-15 | Shriners Hospitals For Cripple | Omega-3-fettsaeuren zur behandlung von traumatischen verwundungen. |
US5034415A (en) * | 1987-08-07 | 1991-07-23 | Century Laboratories, Inc. | Treatment of diabetes mellitus |
US5221668A (en) * | 1992-02-26 | 1993-06-22 | Abbott Laboratories | Nutritional product for trauma and surgery patients |
FR2695317B1 (fr) * | 1992-09-07 | 1995-03-10 | Monal Lab | Composition apte à stimuler la sécrétion d'insuline destinée au traitement du diabète non insulino-dépendant. |
US6210700B1 (en) * | 1997-01-14 | 2001-04-03 | Novartis Nutrition Ag | Enhancement of transplant graft survival through nutritional immunomodulation with omega-9 fatty acid dietary supplement therapy |
US6013273A (en) * | 1997-01-27 | 2000-01-11 | Novartis Nutrition Ag | Treatment of endotoxic shock |
JP2003517018A (ja) * | 1999-12-16 | 2003-05-20 | シスキンド,ハリー | 栄養組成物、該組成物を製造する方法、及び該組成物を使用する方法 |
US6899891B2 (en) * | 1999-12-16 | 2005-05-31 | Harry J. Siskind | Nutritional composition, methods of producing said composition and methods of using said composition |
US6689385B2 (en) * | 2000-11-03 | 2004-02-10 | Chronorx Llc | Formulations for the treatment of insulin resistance and type 2 diabetes mellitus |
-
2004
- 2004-02-23 US US10/546,942 patent/US20060159746A1/en not_active Abandoned
- 2004-02-23 CN CNB2004800069054A patent/CN100415224C/zh not_active Expired - Fee Related
- 2004-02-23 PL PL377614A patent/PL377614A1/pl not_active Application Discontinuation
- 2004-02-23 JP JP2006504450A patent/JP2006520335A/ja active Pending
- 2004-02-23 RU RU2005131995/13A patent/RU2356247C2/ru not_active IP Right Cessation
- 2004-02-23 CA CA002516142A patent/CA2516142A1/fr not_active Abandoned
- 2004-02-23 BR BRPI0408490-0A patent/BRPI0408490A/pt not_active IP Right Cessation
- 2004-02-23 AU AU2004222633A patent/AU2004222633B2/en not_active Ceased
- 2004-02-23 EP EP04713520A patent/EP1605781A1/fr not_active Withdrawn
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- 2004-02-23 WO PCT/EP2004/001763 patent/WO2004082402A1/fr active Search and Examination
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AU2004222633A1 (en) | 2004-09-30 |
CN100415224C (zh) | 2008-09-03 |
US20060159746A1 (en) | 2006-07-20 |
RU2356247C2 (ru) | 2009-05-27 |
JP2006520335A (ja) | 2006-09-07 |
PL377614A1 (pl) | 2006-02-06 |
CA2516142A1 (fr) | 2004-09-30 |
WO2004082402A1 (fr) | 2004-09-30 |
BRPI0408490A (pt) | 2006-04-04 |
RU2005131995A (ru) | 2006-08-10 |
MXPA05009933A (es) | 2005-11-04 |
EP1605781A1 (fr) | 2005-12-21 |
NZ541516A (en) | 2008-05-30 |
CN1761405A (zh) | 2006-04-19 |
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