ZA200505782B - Active immunization to generate antibodies to soluble A-beta - Google Patents
Active immunization to generate antibodies to soluble A-beta Download PDFInfo
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- ZA200505782B ZA200505782B ZA200505782A ZA200505782A ZA200505782B ZA 200505782 B ZA200505782 B ZA 200505782B ZA 200505782 A ZA200505782 A ZA 200505782A ZA 200505782 A ZA200505782 A ZA 200505782A ZA 200505782 B ZA200505782 B ZA 200505782B
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
Landscapes
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- Peptides Or Proteins (AREA)
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| EP (1) | EP1594969B1 (fr) |
| JP (1) | JP2006516639A (fr) |
| KR (1) | KR20050118669A (fr) |
| CN (1) | CN1745175A (fr) |
| AU (1) | AU2004209981B2 (fr) |
| BR (1) | BRPI0407058A (fr) |
| CA (1) | CA2513722A1 (fr) |
| CR (1) | CR7922A (fr) |
| EC (1) | ECSP055939A (fr) |
| ES (1) | ES2545765T3 (fr) |
| HR (1) | HRP20050670A2 (fr) |
| MX (1) | MXPA05008156A (fr) |
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| UA (1) | UA87453C2 (fr) |
| WO (1) | WO2004069182A2 (fr) |
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Families Citing this family (60)
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| US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| EP1594969B1 (fr) * | 2003-02-01 | 2015-05-20 | Janssen Sciences Ireland UC | Immunisation active permettant de produire des anticorps contre a-beta soluble |
| US8663650B2 (en) | 2003-02-21 | 2014-03-04 | Ac Immune Sa | Methods and compositions comprising supramolecular constructs |
| ES2246177B1 (es) * | 2003-05-08 | 2007-03-01 | Universidad De Zaragoza. | Uso de anticuerpos para el tratamiento de enfermedades amiloideas. |
| PE20050627A1 (es) | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
| US7807171B2 (en) | 2003-07-25 | 2010-10-05 | Ac Immune Sa | Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers |
| JP2005181711A (ja) | 2003-12-19 | 2005-07-07 | Ricoh Co Ltd | 画像形成装置及びプロセスカートリッジ |
| AT500483B1 (de) * | 2004-07-13 | 2006-01-15 | Mattner Frank Dr | Set zur vorbeugung oder behandlung der alzheimer'schen erkrankung |
| AU2005294131A1 (en) * | 2004-10-05 | 2006-04-20 | Wyeth | Methods and compositions for improving recombinant protein production |
| CA2590337C (fr) | 2004-12-15 | 2017-07-11 | Neuralab Limited | Anticorps du peptide beta-amyloide humanises utilises dans l'amelioration de la cognition |
| GT200600031A (es) * | 2005-01-28 | 2006-08-29 | Formulacion anticuerpo anti a beta | |
| CN101171031B (zh) * | 2005-05-05 | 2011-09-28 | 默沙东公司 | 防止和治疗阿尔茨海默病的肽偶联物组合物和方法 |
| JPWO2006126682A1 (ja) * | 2005-05-27 | 2008-12-25 | 財団法人化学及血清療法研究所 | アルツハイマー病の予防・治療用ワクチン |
| US7825223B2 (en) | 2005-06-17 | 2010-11-02 | Janssen Alzheimer Immunotherapy | Methods of purifying anti A β antibodies |
| CA2630964A1 (fr) * | 2005-11-22 | 2007-05-31 | The Trustees Of The University Of Pennsylvania | Traitement par anticorps de la maladie d'alzheimer et des maladies connexes |
| KR101439828B1 (ko) | 2005-11-30 | 2014-09-17 | 애브비 인코포레이티드 | 아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의 용도 |
| KR20080090408A (ko) | 2005-11-30 | 2008-10-08 | 아보트 러보러터리즈 | 항-Ａβ 글로불로머 항체, 이의 항원-결합 잔기, 상응하는하이브리도마, 핵산, 벡터, 숙주 세포, 당해 항체의 제조방법, 당해 항체를 포함하는 조성물, 당해 항체의 용도 및당해 항체의 사용 방법 |
| EP2361638B1 (fr) | 2005-12-12 | 2014-01-15 | AC Immune S.A. | Anticorps monoclonaux spécifiques de A beta 1-42 avec des propriétés thérapeutiques |
| US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| CN101058608B (zh) * | 2006-04-21 | 2011-02-23 | 杜如昱 | 人类抗Aβ1-32淀粉样蛋白抗体、其纯化方法及用途 |
| CA2653628C (fr) | 2006-06-01 | 2015-07-14 | Elan Pharmaceuticals, Inc. | Fragments neuroactifs de app |
| TWI551607B (zh) | 2006-07-14 | 2016-10-01 | Ａｃ免疫公司 | 人類化抗體 |
| CA2660830A1 (fr) * | 2006-08-14 | 2008-02-21 | Gideon Goldstein | Compositions et methodes pour le traitement et la prevention d'une infection par de multiples souches et sous-types du vih-1 |
| US20090123488A1 (en) * | 2006-08-14 | 2009-05-14 | Thymon, Llc | Compositions and methods for the treatment and prophylaxis of Alzheimer's disease |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| US8077343B1 (en) | 2007-01-03 | 2011-12-13 | Marvell International Ltd. | Determining end of print job in handheld image translation device |
| US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
| ZA200905537B (en) | 2007-03-01 | 2010-10-27 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
| US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| ES2533484T3 (es) | 2007-04-18 | 2015-04-10 | Probiodrug Ag | Derivados de tiourea como inhibidores de la glutaminil ciclasa |
| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| BR122019000258B1 (pt) * | 2007-07-26 | 2021-09-14 | Revance Therapeutics, Inc | Composição farmacêutica ou cosmética compreendendo um peptídeo catiônico e kit para administração da mesma |
| SI2182983T1 (sl) | 2007-07-27 | 2014-09-30 | Janssen Alzheimer Immunotherapy | Zdravljenje amiloidogenih bolezni s humaniziranimi protitelesi proti abeta |
| AU2008299516B2 (en) * | 2007-09-13 | 2013-09-12 | Delenex Therapeutics Ag | Humanized antibodies against the beta-amyloyd peptide |
| PT2238166E (pt) * | 2007-10-05 | 2014-02-11 | Genentech Inc | Utilização do anticorpo anti-amilóide beta em doenças oculares |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| EA022007B1 (ru) | 2009-09-11 | 2015-10-30 | Пробиодруг Аг | Гетероциклические производные в качестве ингибиторов глутаминилциклазы |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| KR101790806B1 (ko) | 2010-03-10 | 2017-11-20 | 프로비오드룩 아게 | 글루타미닐 사이클라제(ｑｃ, ｅｃ 2.3.2.5)의 헤테로사이클릭 억제제 |
| WO2011130377A2 (fr) | 2010-04-15 | 2011-10-20 | Abbott Laboratories | Protéines de liaison à la bêta amyloïde |
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| US20060240486A1 (en) * | 2004-12-15 | 2006-10-26 | Johnson-Wood Kelly L | Immunoprecipitation-based assay for predicting in vivo efficacy of beta-amyloid antibodies |
| GT200600031A (es) * | 2005-01-28 | 2006-08-29 | Formulacion anticuerpo anti a beta | |
| MX2007009091A (es) * | 2005-01-28 | 2008-01-11 | Wyeth Corp | Formulaciones de polipeptido liquidas estabilizadas. |
| US7825223B2 (en) * | 2005-06-17 | 2010-11-02 | Janssen Alzheimer Immunotherapy | Methods of purifying anti A β antibodies |
| US8211904B2 (en) * | 2005-07-18 | 2012-07-03 | Merck, Sharp & Dohme Corp. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
| KR20080095836A (ko) * | 2005-11-10 | 2008-10-29 | 로스캄프 리서치 엘엘씨 | Ａ―베타 펩티드 단편에 의한 혈관형성의 조정 |
| US8784810B2 (en) * | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| MX2009011127A (es) * | 2007-04-18 | 2010-03-10 | Janssen Alzheimer Immunotherap | Metodo de prevencion y tratamiento de angiopatia amiloide cerebral. |
| US8003097B2 (en) * | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| SI2182983T1 (sl) * | 2007-07-27 | 2014-09-30 | Janssen Alzheimer Immunotherapy | Zdravljenje amiloidogenih bolezni s humaniziranimi protitelesi proti abeta |
| JO3076B1 (ar) * | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| EA036059B1 (ru) * | 2007-12-28 | 2020-09-21 | Протена Байосайенсиз Лимитед | Способ получения антитела или его фрагмента, которое специфически связывается с агрегированным амилоидным белком |
-
2004
- 2004-01-31 EP EP20040707166 patent/EP1594969B1/fr not_active Expired - Lifetime
- 2004-01-31 CN CNA2004800031377A patent/CN1745175A/zh active Pending
- 2004-01-31 MX MXPA05008156A patent/MXPA05008156A/es active IP Right Grant
- 2004-01-31 RU RU2005127429/14A patent/RU2390350C2/ru not_active IP Right Cessation
- 2004-01-31 PL PL378571A patent/PL378571A1/pl not_active Application Discontinuation
- 2004-01-31 UA UAA200507593A patent/UA87453C2/ru unknown
- 2004-01-31 ES ES04707166.7T patent/ES2545765T3/es not_active Expired - Lifetime
- 2004-01-31 KR KR1020057014123A patent/KR20050118669A/ko not_active Application Discontinuation
- 2004-01-31 BR BR0407058-5A patent/BRPI0407058A/pt not_active IP Right Cessation
- 2004-01-31 CA CA002513722A patent/CA2513722A1/fr not_active Abandoned
- 2004-01-31 AU AU2004209981A patent/AU2004209981B2/en not_active Ceased
- 2004-01-31 NZ NZ567324A patent/NZ567324A/en not_active IP Right Cessation
- 2004-01-31 WO PCT/US2004/002856 patent/WO2004069182A2/fr active Application Filing
- 2004-01-31 US US10/544,093 patent/US20060188512A1/en not_active Abandoned
- 2004-01-31 ZA ZA200505782A patent/ZA200505782B/en unknown
- 2004-01-31 JP JP2006503233A patent/JP2006516639A/ja active Pending
- 2004-02-02 US US10/771,174 patent/US20040213800A1/en not_active Abandoned
-
2005
- 2005-07-22 CR CR7922A patent/CR7922A/es not_active Application Discontinuation
- 2005-07-22 HR HR20050670A patent/HRP20050670A2/hr not_active Application Discontinuation
- 2005-08-01 EC EC2005005939A patent/ECSP055939A/es unknown
- 2005-08-18 NO NO20053862A patent/NO20053862L/no unknown
-
2008
- 2008-02-25 US US12/037,045 patent/US20080279873A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA05008156A (es) | 2005-09-30 |
| AU2004209981A1 (en) | 2004-08-19 |
| WO2004069182A2 (fr) | 2004-08-19 |
| AU2004209981B2 (en) | 2009-02-26 |
| CA2513722A1 (fr) | 2004-08-19 |
| KR20050118669A (ko) | 2005-12-19 |
| PL378571A1 (pl) | 2006-05-02 |
| ECSP055939A (es) | 2006-04-19 |
| EP1594969B1 (fr) | 2015-05-20 |
| NZ567324A (en) | 2009-08-28 |
| ES2545765T3 (es) | 2015-09-15 |
| JP2006516639A (ja) | 2006-07-06 |
| HRP20050670A2 (en) | 2005-12-31 |
| CR7922A (es) | 2006-02-07 |
| NO20053862D0 (no) | 2005-08-18 |
| CN1745175A (zh) | 2006-03-08 |
| US20040213800A1 (en) | 2004-10-28 |
| EP1594969A4 (fr) | 2006-07-26 |
| EP1594969A2 (fr) | 2005-11-16 |
| NO20053862L (no) | 2005-10-31 |
| US20060188512A1 (en) | 2006-08-24 |
| WO2004069182A3 (fr) | 2005-03-03 |
| RU2005127429A (ru) | 2006-02-10 |
| UA87453C2 (ru) | 2009-07-27 |
| US20080279873A1 (en) | 2008-11-13 |
| RU2390350C2 (ru) | 2010-05-27 |
| BRPI0407058A (pt) | 2006-01-17 |
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