ZA200505324B - Noel heteroatom containing tetracyclic derivativesas selective estrogen receptor modulators - Google Patents
Noel heteroatom containing tetracyclic derivativesas selective estrogen receptor modulators Download PDFInfo
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- ZA200505324B ZA200505324B ZA200505324A ZA200505324A ZA200505324B ZA 200505324 B ZA200505324 B ZA 200505324B ZA 200505324 A ZA200505324 A ZA 200505324A ZA 200505324 A ZA200505324 A ZA 200505324A ZA 200505324 B ZA200505324 B ZA 200505324B
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- South Africa
- Prior art keywords
- alkyl
- group
- phenyl
- hydroxy
- ethoxy
- Prior art date
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- 229940095743 selective estrogen receptor modulator Drugs 0.000 title description 6
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
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- Rheumatology (AREA)
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- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/307,735 US7329654B2 (en) | 2001-12-19 | 2002-12-02 | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200505324B true ZA200505324B (en) | 2006-09-27 |
Family
ID=32467796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200505324A ZA200505324B (en) | 2002-12-02 | 2005-06-30 | Noel heteroatom containing tetracyclic derivativesas selective estrogen receptor modulators |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7329654B2 (zh) |
| EP (1) | EP1569939A1 (zh) |
| JP (1) | JP2006514941A (zh) |
| CN (2) | CN101450950A (zh) |
| AU (1) | AU2003295822A1 (zh) |
| BR (1) | BR0316843A (zh) |
| CA (1) | CA2505857A1 (zh) |
| MX (1) | MXPA05005897A (zh) |
| NZ (1) | NZ539914A (zh) |
| PL (1) | PL376803A1 (zh) |
| RU (1) | RU2331645C2 (zh) |
| WO (1) | WO2004050660A1 (zh) |
| ZA (1) | ZA200505324B (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| PL1812417T3 (pl) * | 2004-11-18 | 2009-04-30 | Janssen Pharmaceutica Nv | Nowe pochodne 2H-chromenu jako selektywne modulatory receptora estrogenu |
| EP1846386A2 (en) * | 2005-01-21 | 2007-10-24 | Janssen Pharmaceutica N.V. | Novel coumarin derivatives as ion channel openers |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| JP6285866B2 (ja) | 2011-11-23 | 2018-02-28 | セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． | 天然複合ホルモン補充製剤および療法 |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| WO2015089810A1 (en) * | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Fused tetracyclic heterocyclic compounds and methods of use thereof for the treatment of viral diseases |
| KR20170005819A (ko) | 2014-05-22 | 2017-01-16 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 천연 복합 호르몬 대체 제형 및 요법 |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| WO2017173071A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| TWI702219B (zh) * | 2018-07-12 | 2020-08-21 | 美商美國禮來大藥廠 | 選擇性雌激素受體降解劑 |
| PL3820874T3 (pl) * | 2018-07-12 | 2023-02-06 | Eli Lilly And Company | Selektywne środki degradujące receptor estrogenowy |
| CN111039910A (zh) * | 2019-12-31 | 2020-04-21 | 云南大学 | 一种光引发的合成3-芳基黄酮或香豆素类化合物的方法及应用 |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL124481C (zh) | 1964-11-04 | |||
| US5395842A (en) | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
| US5686465A (en) | 1988-10-31 | 1997-11-11 | Endorecherche Inc. | Sex steroid activity inhibitors |
| IN173337B (zh) | 1989-11-08 | 1994-04-02 | Council Scient Ind Res | |
| DE69023906T2 (de) | 1990-08-09 | 1996-04-11 | Council Scient Ind Res | Benzopyrane und Verfahren zu deren Herstellung. |
| US6060503A (en) | 1991-12-02 | 2000-05-09 | Endorecherche, Inc. | Benzopyran-containing compounds and method for their use |
| US5726186A (en) | 1995-09-08 | 1998-03-10 | Eli Lilly And Company | Pentacyclic compounds, intermediates, processes, compositions, and methods |
| CA2214196A1 (en) | 1996-09-26 | 1998-03-26 | Eli Lilly And Company | Benzo[b]indeno[2,1-d]thiophene compounds, intermediates, processes, compositions and methods |
| DE69716292T2 (de) | 1996-12-13 | 2003-07-03 | Chugai Pharmaceutical Co Ltd | Benzopyranderivate |
| PT1467998E (pt) | 2001-12-19 | 2006-08-31 | Ortho Mcneil Pharm Inc | Heterocompostos tetraciclicos como moduladores do receptor do estrogenio |
-
2002
- 2002-12-02 US US10/307,735 patent/US7329654B2/en not_active Expired - Fee Related
-
2003
- 2003-11-21 EP EP03787032A patent/EP1569939A1/en not_active Ceased
- 2003-11-21 MX MXPA05005897A patent/MXPA05005897A/es active IP Right Grant
- 2003-11-21 CN CNA2008101901315A patent/CN101450950A/zh active Pending
- 2003-11-21 CN CNA2003801093959A patent/CN1745085A/zh active Pending
- 2003-11-21 RU RU2005116845/04A patent/RU2331645C2/ru active
- 2003-11-21 JP JP2004557261A patent/JP2006514941A/ja not_active Withdrawn
- 2003-11-21 NZ NZ539914A patent/NZ539914A/en unknown
- 2003-11-21 WO PCT/US2003/037419 patent/WO2004050660A1/en active Application Filing
- 2003-11-21 AU AU2003295822A patent/AU2003295822A1/en not_active Abandoned
- 2003-11-21 BR BR0316843-3A patent/BR0316843A/pt not_active IP Right Cessation
- 2003-11-21 CA CA002505857A patent/CA2505857A1/en not_active Abandoned
- 2003-11-21 PL PL376803A patent/PL376803A1/pl unknown
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- 2005-06-30 ZA ZA200505324A patent/ZA200505324B/en unknown
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| Publication number | Publication date |
|---|---|
| RU2331645C2 (ru) | 2008-08-20 |
| WO2004050660A1 (en) | 2004-06-17 |
| CN101450950A (zh) | 2009-06-10 |
| JP2006514941A (ja) | 2006-05-18 |
| EP1569939A1 (en) | 2005-09-07 |
| CN1745085A (zh) | 2006-03-08 |
| BR0316843A (pt) | 2005-11-01 |
| NZ539914A (en) | 2008-03-28 |
| AU2003295822A1 (en) | 2004-06-23 |
| US20030216463A1 (en) | 2003-11-20 |
| CA2505857A1 (en) | 2004-06-17 |
| RU2005116845A (ru) | 2006-01-20 |
| US7329654B2 (en) | 2008-02-12 |
| MXPA05005897A (es) | 2006-02-08 |
| PL376803A1 (pl) | 2006-01-09 |
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