ZA200505308B - Fluoroalkoxy-substituted 1, 3-Dihydro-Isoindolyl compounds and their pharmaceutical uses - Google Patents

Fluoroalkoxy-substituted 1, 3-Dihydro-Isoindolyl compounds and their pharmaceutical uses Download PDF

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Publication number
ZA200505308B
ZA200505308B ZA200505308A ZA200505308A ZA200505308B ZA 200505308 B ZA200505308 B ZA 200505308B ZA 200505308 A ZA200505308 A ZA 200505308A ZA 200505308 A ZA200505308 A ZA 200505308A ZA 200505308 B ZA200505308 B ZA 200505308B
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compound
alkyl
mammal
effective amount
pharmaceutically acceptable
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ZA200505308A
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English (en)
Inventor
George W Muller
Man Hon-Wah
Zhang Weihong
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Celgene Corp
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Publication of ZA200505308B publication Critical patent/ZA200505308B/en

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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ZA200505308A 2002-12-30 2003-12-29 Fluoroalkoxy-substituted 1, 3-Dihydro-Isoindolyl compounds and their pharmaceutical uses ZA200505308B (en)

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US43697502P 2002-12-30 2002-12-30

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ZA200505308B true ZA200505308B (en) 2006-10-25

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US (4) US7173058B2 (enExample)
EP (1) EP1587474B1 (enExample)
JP (2) JP5269281B2 (enExample)
KR (1) KR20050090435A (enExample)
CN (1) CN1802353A (enExample)
AT (1) ATE449081T1 (enExample)
AU (1) AU2003303511B2 (enExample)
BR (1) BR0317885A (enExample)
CA (1) CA2511843C (enExample)
DE (1) DE60330187D1 (enExample)
ES (1) ES2333220T3 (enExample)
IL (1) IL169439A0 (enExample)
MX (1) MXPA05006998A (enExample)
NZ (1) NZ541487A (enExample)
TW (1) TW200418779A (enExample)
WO (1) WO2004060313A2 (enExample)
ZA (1) ZA200505308B (enExample)

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