ZA200502575B - Cell-based detection and differentiation of disease states - Google Patents
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Families Citing this family (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2361996B (en) * | 1998-10-29 | 2004-05-12 | Cell Works Inc | Multiple marker characterization of single cells |
US20040115692A1 (en) * | 2000-04-03 | 2004-06-17 | Cytyc Corporation | Methods, compositions and apparatuses for detecting a target in a preservative solution |
US7298877B1 (en) * | 2001-11-20 | 2007-11-20 | Icad, Inc. | Information fusion with Bayes networks in computer-aided detection systems |
WO2004029221A2 (en) | 2002-09-27 | 2004-04-08 | The General Hospital Corporation | Microfluidic device for cell separation and uses thereof |
US7943294B2 (en) * | 2004-07-30 | 2011-05-17 | Hologic, Inc. | Methods for detecting oncofetal fibronectin |
US20090162839A1 (en) * | 2004-08-31 | 2009-06-25 | Board Of Regents, The University Of Texas System | Diagnosis and prognosis of cancer based on telomere length as measured on cytological specimens |
CA2584197A1 (en) * | 2004-10-14 | 2006-04-27 | Genentech, Inc. | Cop1 molecules and uses thereof |
WO2006084195A2 (en) * | 2005-02-03 | 2006-08-10 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Personal assessment including familial risk analysis for personalized disease prevention plan |
US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
ATE527542T1 (de) * | 2005-04-27 | 2011-10-15 | Siemens Medical Solutions | Verfahren zur herstellung von abbildungssonden unter verwendung von click chemie |
US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
EP1930445B1 (en) * | 2005-09-02 | 2010-03-31 | Toray Industries, Inc. | Kit and method for detection of urothelial cancer |
CN102260742A (zh) * | 2005-10-21 | 2011-11-30 | 基因信息股份有限公司 | 用于使生物标志产物水平与疾病相关联的方法和装置 |
US20070122041A1 (en) * | 2005-11-29 | 2007-05-31 | Baback Moghaddam | Spectral method for sparse linear discriminant analysis |
DE602007009645D1 (de) * | 2006-02-16 | 2010-11-18 | Ventana Med Syst Inc | Reagenzien und verfahren für krebsprognose und pathologische einstufung |
US20070207467A1 (en) * | 2006-03-01 | 2007-09-06 | Ming Xu | Detection of lymph node metastasis from gastric carcinoma |
US20090130108A1 (en) * | 2006-03-21 | 2009-05-21 | The Regents Of The University Of California | N-Cadherin and Ly6 E: Targets for Cancer Diagnosis and Therapy |
US20100278821A1 (en) * | 2006-03-21 | 2010-11-04 | The Regents Of The University Of California | N-cadherin: target for cancer diagnosis and therapy |
US8663635B2 (en) | 2006-03-21 | 2014-03-04 | The Regents Of The University Of California | N-cadherin: target for cancer diagnosis and therapy |
US20070281305A1 (en) * | 2006-06-05 | 2007-12-06 | Sean Wuxiong Cao | Detection of lymph node metastasis from gastric carcinoma |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
US8372584B2 (en) | 2006-06-14 | 2013-02-12 | The General Hospital Corporation | Rare cell analysis using sample splitting and DNA tags |
WO2007147074A2 (en) | 2006-06-14 | 2007-12-21 | Living Microsystems, Inc. | Use of highly parallel snp genotyping for fetal diagnosis |
US8338109B2 (en) | 2006-11-02 | 2012-12-25 | Mayo Foundation For Medical Education And Research | Predicting cancer outcome |
US8278056B2 (en) * | 2008-06-13 | 2012-10-02 | Oncohealth Corp. | Detection of early stages and late stages HPV infection |
US8968995B2 (en) * | 2008-11-12 | 2015-03-03 | Oncohealth Corp. | Detection, screening, and diagnosis of HPV-associated cancers |
WO2010129821A1 (en) | 2009-05-07 | 2010-11-11 | Oncohealth Corporation | Identification of high grade or ≥cin2 for early stages and late stages detection, screening, and diagnosis of human papillomavirus (hpv) and hpv-associated cancers |
US7824871B2 (en) * | 2007-06-14 | 2010-11-02 | George Mason Intellectual Properties | Methods of diagnosing non-alcoholic steatohepatitis (NASH) |
US8541183B2 (en) * | 2007-09-11 | 2013-09-24 | Cancer Prevention And Cure, Ltd. | Methods of identification, assessment, prevention and therapy of lung diseases and kits thereof |
US7888051B2 (en) * | 2007-09-11 | 2011-02-15 | Cancer Prevention And Cure, Ltd. | Method of identifying biomarkers in human serum indicative of pathologies of human lung tissues |
JP5378228B2 (ja) * | 2007-10-29 | 2013-12-25 | シスメックス株式会社 | 細胞分析装置及び細胞分析方法 |
US8617806B2 (en) * | 2008-01-25 | 2013-12-31 | Hansabiomed Ou | Method to measure and characterize microvesicles in the human body fluids |
AU2009210848B2 (en) * | 2008-02-08 | 2013-12-19 | Phadia Ab | Method, computer program product and system for enabling clinical decision support |
MX2010010835A (es) * | 2008-04-04 | 2011-02-22 | Univ California | Novedosos anticuerpos contra cancer dirigidos a bloqueo de crecimiento de tumor, angiogenesis y metastasis. |
EP2806054A1 (en) | 2008-05-28 | 2014-11-26 | Genomedx Biosciences Inc. | Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer |
US10407731B2 (en) | 2008-05-30 | 2019-09-10 | Mayo Foundation For Medical Education And Research | Biomarker panels for predicting prostate cancer outcomes |
CA3011730C (en) * | 2008-09-09 | 2022-05-17 | Somalogic, Inc. | Lung cancer biomarkers and uses thereof |
LT2562268T (lt) | 2008-09-20 | 2017-04-25 | The Board Of Trustees Of The Leland Stanford Junior University | Neinvazinis fetalinės aneuploidijos diagnozavimas sekvenavimu |
US8703920B2 (en) * | 2008-11-10 | 2014-04-22 | The Regents Of The University Of California | Fully human antibodies against N-cadherin |
US9495515B1 (en) | 2009-12-09 | 2016-11-15 | Veracyte, Inc. | Algorithms for disease diagnostics |
US8541170B2 (en) | 2008-11-17 | 2013-09-24 | Veracyte, Inc. | Methods and compositions of molecular profiling for disease diagnostics |
US10236078B2 (en) | 2008-11-17 | 2019-03-19 | Veracyte, Inc. | Methods for processing or analyzing a sample of thyroid tissue |
FR2942319B1 (fr) * | 2009-02-13 | 2011-03-18 | Novacyt | Procede de preparation d'une plaque d'analyse virtuelle traitee |
US9074258B2 (en) | 2009-03-04 | 2015-07-07 | Genomedx Biosciences Inc. | Compositions and methods for classifying thyroid nodule disease |
EP3257953B1 (en) | 2009-03-12 | 2018-09-26 | Cancer Prevention And Cure, Ltd. | Methods of identification, assessment, prevention and therapy of lung diseases and kits thereof including gender-based disease identification, assessment, prevention and therapy |
WO2010117711A1 (en) * | 2009-03-29 | 2010-10-14 | University Of Florida Research Foundation, Inc. | Systems and methods for tuning automatic speech recognition systems |
WO2010129934A2 (en) | 2009-05-07 | 2010-11-11 | Veracyte, Inc. | Methods and compositions for diagnosis of thyroid conditions |
TWI497075B (zh) * | 2009-06-11 | 2015-08-21 | Oncohealth Corp | 早期及晚期人類乳突病毒感染之偵測 |
US8811535B2 (en) * | 2009-07-17 | 2014-08-19 | Mitre Corporation | Time-frequency space constructions of families of signals |
CA2781408A1 (en) * | 2009-11-20 | 2011-05-26 | University Of Louisville Research Foundation Inc. | Biomarkers of cancer |
US10446272B2 (en) | 2009-12-09 | 2019-10-15 | Veracyte, Inc. | Methods and compositions for classification of samples |
EP2521914A4 (en) | 2010-01-08 | 2013-07-10 | Oncohealth Corp | CELL-BASED HPV IMMUNOTESTS HAVE A HIGH PERFORMANCE FOR DIAGNOSIS AND SCANNING OF HPV ASSOCIATED CANCER |
CN103038635B (zh) | 2010-05-11 | 2016-12-28 | 威拉赛特公司 | 用于诊断病状的方法和组合物 |
US9514250B2 (en) * | 2010-07-29 | 2016-12-06 | General Electric Company | System and method for analyzing and visualizing enumerated information |
WO2012070970A1 (ru) * | 2010-11-22 | 2012-05-31 | Farber Boris Slavinovich | Диагностический способ для прогноза развития и контроля эффективности лечения онкологических заболеваний |
US20130029302A1 (en) * | 2011-07-28 | 2013-01-31 | Jill Joyce | Psychiatric assessment by pre-screening and correlation of underlying physical conditions |
US20130143237A1 (en) | 2011-11-29 | 2013-06-06 | Genentech, Inc. | Compositions and methods for prostate cancer analysis |
US10513737B2 (en) | 2011-12-13 | 2019-12-24 | Decipher Biosciences, Inc. | Cancer diagnostics using non-coding transcripts |
US10158898B2 (en) | 2012-07-26 | 2018-12-18 | Comcast Cable Communications, Llc | Customized options for consumption of content |
DK3435084T3 (da) | 2012-08-16 | 2023-05-30 | Mayo Found Medical Education & Res | Prostatakræftprognose under anvendelse af biomarkører |
GB2525804B (en) | 2013-03-15 | 2020-08-05 | Veracyte Inc | Methods and compositions for classification of samples |
US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
EP2978863B1 (en) * | 2013-03-28 | 2021-03-10 | Advanced Cell Diagnostics, Inc. | Differentiation between transient and persistent high risk hpv infection by in situ hybridization |
WO2015010596A1 (zh) * | 2013-07-22 | 2015-01-29 | 北京盛诺基医药科技有限公司 | 一种乳腺癌预后诊断的方法 |
DE102013015156B4 (de) * | 2013-09-11 | 2016-10-20 | Unify Gmbh & Co. Kg | System und Verfahren zum Ermitteln des Präsenzstatus eines in einem Netzwerk registrierten Benutzers |
US20160334389A1 (en) * | 2014-01-14 | 2016-11-17 | Won Cheol Choi | Method for screening cancer prevention agent or anticancer agent using morphological characteristics of luterial |
CA2951514A1 (en) | 2014-06-18 | 2015-12-23 | Clear Gene, Inc. | Methods, compositions, and devices for rapid analysis of biological markers |
EP3770274A1 (en) | 2014-11-05 | 2021-01-27 | Veracyte, Inc. | Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data |
US11401558B2 (en) | 2015-12-18 | 2022-08-02 | Clear Gene, Inc. | Methods, compositions, kits and devices for rapid analysis of biological markers |
CN107194137B (zh) * | 2016-01-31 | 2023-05-23 | 北京万灵盘古科技有限公司 | 一种基于医疗数据建模的坏死性小肠结肠炎分类预测方法 |
CN106282116A (zh) * | 2016-08-08 | 2017-01-04 | 北京科迅生物技术有限公司 | 一种结直肠癌循环肿瘤细胞的富集和分析方法 |
EP3504348B1 (en) | 2016-08-24 | 2022-12-14 | Decipher Biosciences, Inc. | Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy |
CN108133122B (zh) * | 2016-12-01 | 2020-09-15 | 深圳华大基因股份有限公司 | 基因聚类方法和基于该方法的宏基因组组装方法和装置 |
US11208697B2 (en) | 2017-01-20 | 2021-12-28 | Decipher Biosciences, Inc. | Molecular subtyping, prognosis, and treatment of bladder cancer |
CN106919801B (zh) * | 2017-03-08 | 2023-07-18 | 杭州大伽信息科技有限公司 | 一种免疫组织化学染色辅助分析系统及使用方法 |
US11873532B2 (en) | 2017-03-09 | 2024-01-16 | Decipher Biosciences, Inc. | Subtyping prostate cancer to predict response to hormone therapy |
WO2018187496A2 (en) | 2017-04-04 | 2018-10-11 | Lung Cancer Proteomics, Llc | Plasma based protein profiling for early stage lung cancer prognosis |
WO2018205035A1 (en) | 2017-05-12 | 2018-11-15 | Genomedx Biosciences, Inc | Genetic signatures to predict prostate cancer metastasis and identify tumor agressiveness |
US10327637B2 (en) * | 2017-06-08 | 2019-06-25 | Fdna Inc. | Systems, methods, and computer-readable media for patient image analysis to identify new diseases |
US11217329B1 (en) | 2017-06-23 | 2022-01-04 | Veracyte, Inc. | Methods and systems for determining biological sample integrity |
CN107367616B (zh) * | 2017-07-27 | 2019-01-15 | 临沂大学 | 一种前列腺特异性抗原检测试剂与试剂盒 |
CN107475202A (zh) * | 2017-08-18 | 2017-12-15 | 河南省肿瘤医院 | 一种肺癌循环肿瘤细胞捕获与活性检测、分析方法及其应用 |
US10939806B2 (en) * | 2018-03-06 | 2021-03-09 | Advinow, Inc. | Systems and methods for optical medical instrument patient measurements |
US11348688B2 (en) | 2018-03-06 | 2022-05-31 | Advinow, Inc. | Systems and methods for audio medical instrument patient measurements |
CA3136245A1 (en) * | 2018-04-13 | 2019-10-17 | Bioaffinity Technologies, Inc. | System and method for determining lung health |
CN108760448B (zh) * | 2018-05-31 | 2024-08-16 | 广州江元医疗科技有限公司 | 全自动阴道分泌物染色机 |
US20210254173A1 (en) * | 2018-06-15 | 2021-08-19 | West Virginia University | Predictive 7-gene assay and prognostic protein biomarker for non-small cell lung cancer |
CN108846896A (zh) * | 2018-06-29 | 2018-11-20 | 南华大学 | 一种自动分子蛋白质分子体学诊断系统 |
CN109554505B (zh) * | 2018-12-26 | 2022-02-18 | 广东和信健康科技有限公司 | 一组检测hpv高危型和中危型核酸的探针及其检测试剂盒和应用 |
EP3935581A4 (en) | 2019-03-04 | 2022-11-30 | Iocurrents, Inc. | DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING |
WO2020216437A1 (en) * | 2019-04-23 | 2020-10-29 | Espire Technologies Gmbh | Device and method for localising or identifying malignancies |
CN110376198B (zh) * | 2019-08-29 | 2021-08-10 | 广州锟元方青医疗科技有限公司 | 一种宫颈液基细胞切片质量检测系统 |
US11795495B1 (en) * | 2019-10-02 | 2023-10-24 | FOXO Labs Inc. | Machine learned epigenetic status estimator |
CN111596059A (zh) * | 2020-05-19 | 2020-08-28 | 上海长海医院 | Gankyrin蛋白作为新型分子标志物在前列腺癌预后评估中的应用 |
US20230305014A1 (en) * | 2020-08-11 | 2023-09-28 | The Regents Of The University Of Michigan | Methods of determining risk of and treating cancer recurrence |
CN112002414B (zh) * | 2020-08-23 | 2024-01-26 | 吾征智能技术(北京)有限公司 | 一种基于胃液认知胃病的系统、设备、存储介质 |
KR102577229B1 (ko) * | 2021-05-25 | 2023-09-12 | 주식회사 에이치이엠파마 | 머신러닝 모델을 이용하여 복통 유무를 판별하는 방법 및 진단 장치 |
CN114638782B (zh) * | 2022-01-10 | 2023-02-07 | 武汉中纪生物科技有限公司 | 一种宫颈脱落细胞标本的检测方法 |
WO2024090265A1 (ja) * | 2022-10-28 | 2024-05-02 | 株式会社biomy | 情報処理装置、情報処理方法及びプログラム |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4579827A (en) * | 1983-03-11 | 1986-04-01 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibodies to human gastrointestinal cancers and hybridoma method of production of the monoclonal antibodies |
AU7357687A (en) * | 1986-04-29 | 1987-11-24 | Murex Corp. | Diagnostic kit for sexually transmitted diseases |
US4853770A (en) * | 1988-03-01 | 1989-08-01 | Joe Schneller | Video system for viewing microscopic specimens |
US5380645A (en) * | 1989-03-16 | 1995-01-10 | The Johns Hopkins University | Generalized method for assessment of colorectal carcinoma |
US5784162A (en) * | 1993-08-18 | 1998-07-21 | Applied Spectral Imaging Ltd. | Spectral bio-imaging methods for biological research, medical diagnostics and therapy |
US5543291A (en) * | 1993-01-29 | 1996-08-06 | Dana Farber Cancer Institute | Method of detecting carcinoma |
BR9404967A (pt) * | 1993-04-14 | 1999-06-15 | Int Murex Tech Corp | Imunoensaio |
WO1994028174A1 (en) * | 1993-05-24 | 1994-12-08 | Amoco Corporation | Nucleic acid probes for bacteria of the genus legionella |
IT1270951B (it) * | 1993-06-07 | 1997-05-26 | Boehringer Mannheim Italia | Metodo e dispositivo per il rilevamento simultano di neisseria gonorrhoeae, chlamydia trachomatis e mycoplasma |
US5895748A (en) * | 1996-11-27 | 1999-04-20 | Johnson; Keith R. | Panel of antibodies for detecting cadherins and catenins in tissues and method of using the panel of antibodies |
NO308755B1 (no) * | 1996-12-20 | 2000-10-23 | Iystein Fodstad | FremgangsmÕte til karakterisering av unormale celler, anvendelse og sett for utførelse av fremgangsmÕten |
AU3316600A (en) * | 1999-02-22 | 2000-09-21 | Torben F. Orntoft | Gene expression in bladder tumors |
GB0018140D0 (en) * | 2000-07-24 | 2000-09-13 | Medical Res Council | Screening for abnormalities |
US20030049701A1 (en) * | 2000-09-29 | 2003-03-13 | Muraca Patrick J. | Oncology tissue microarrays |
CN1554025A (zh) * | 2001-03-12 | 2004-12-08 | Īŵ���ɷ�����˾ | 患病状态的细胞为基础的检测和鉴别 |
US7219016B2 (en) * | 2001-04-20 | 2007-05-15 | Yale University | Systems and methods for automated analysis of cells and tissues |
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EP1546709A2 (en) | 2005-06-29 |
CA2498411A1 (en) | 2004-03-25 |
KR20060011817A (ko) | 2006-02-03 |
WO2004025251A3 (en) | 2004-11-04 |
JP2006509185A (ja) | 2006-03-16 |
EP1546709A4 (en) | 2007-09-26 |
WO2004025251A2 (en) | 2004-03-25 |
AU2003267105A1 (en) | 2004-04-30 |
US20030190602A1 (en) | 2003-10-09 |
CN1695057A (zh) | 2005-11-09 |
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