ZA200501008B - A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods for preparing same - Google Patents

A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods for preparing same

Info

Publication number
ZA200501008B
ZA200501008B ZA200501008A ZA200501008A ZA200501008B ZA 200501008 B ZA200501008 B ZA 200501008B ZA 200501008 A ZA200501008 A ZA 200501008A ZA 200501008 A ZA200501008 A ZA 200501008A ZA 200501008 B ZA200501008 B ZA 200501008B
Authority
ZA
South Africa
Prior art keywords
new
epothilone derivatives
preparation
methods
well
Prior art date
Application number
ZA200501008A
Other languages
English (en)
Inventor
Koch Guido
Loiseleur Olivier
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9944042&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200501008(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ZA200501008B publication Critical patent/ZA200501008B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA200501008A 2002-09-13 2005-02-03 A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods for preparing same ZA200501008B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0221312.2A GB0221312D0 (en) 2002-09-13 2002-09-13 Organic compounds

Publications (1)

Publication Number Publication Date
ZA200501008B true ZA200501008B (en) 2006-12-27

Family

ID=9944042

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200501008A ZA200501008B (en) 2002-09-13 2005-02-03 A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods for preparing same

Country Status (30)

Country Link
US (1) US7470792B2 (de)
EP (1) EP1539768B1 (de)
JP (1) JP4628102B2 (de)
KR (1) KR20050042500A (de)
CN (1) CN100522968C (de)
AR (1) AR041231A1 (de)
AT (1) ATE373663T1 (de)
AU (2) AU2003267349B2 (de)
BR (1) BR0314263A (de)
CA (1) CA2497119C (de)
CY (1) CY1107794T1 (de)
DE (1) DE60316456T2 (de)
DK (1) DK1539768T3 (de)
EC (1) ECSP055652A (de)
ES (1) ES2290489T3 (de)
GB (1) GB0221312D0 (de)
HK (1) HK1078853A1 (de)
IL (1) IL166829A (de)
MX (1) MXPA05002785A (de)
MY (1) MY140442A (de)
NO (1) NO20051794L (de)
NZ (1) NZ538612A (de)
PE (1) PE20050052A1 (de)
PL (1) PL375039A1 (de)
PT (1) PT1539768E (de)
RU (2) RU2404985C2 (de)
SG (1) SG155770A1 (de)
TW (1) TWI289563B (de)
WO (1) WO2004024735A2 (de)
ZA (1) ZA200501008B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101173510B1 (ko) 2002-08-23 2012-08-21 슬로안-케테링인스티튜트퍼캔서리서치 에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
EA035193B1 (ru) 2010-05-18 2020-05-14 Серулин Фарма Инк. Композиции и способы лечения аутоиммунных и других заболеваний

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6441186B1 (en) * 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
US6498257B1 (en) * 1998-04-21 2002-12-24 Bristol-Myers Squibb Company 2,3-olefinic epothilone derivatives
GB9810659D0 (en) * 1998-05-18 1998-07-15 Ciba Geigy Ag Organic compounds
JP2003505459A (ja) 1999-07-22 2003-02-12 シエーリング アクチエンゲゼルシャフト エポチロンｂおよび誘導体製造のための方法、ならびにこの方法のための中間製品
US6593115B2 (en) * 2000-03-24 2003-07-15 Bristol-Myers Squibb Co. Preparation of epothilone intermediates
WO2002030356A2 (en) * 2000-10-13 2002-04-18 The University Of Mississipi Synthesis of epothilones and relates analogs
BR0313043A (pt) * 2002-07-31 2005-06-14 Schering Ag Conjugados efetores, processo para sua produção e seu uso farmacêutico

Also Published As

Publication number Publication date
US20060106073A1 (en) 2006-05-18
JP4628102B2 (ja) 2011-02-09
EP1539768B1 (de) 2007-09-19
ES2290489T3 (es) 2008-02-16
CA2497119A1 (en) 2004-03-25
NO20051794D0 (no) 2005-04-12
AU2008203451A1 (en) 2008-08-21
HK1078853A1 (en) 2006-03-24
DK1539768T3 (da) 2008-01-07
IL166829A (en) 2011-01-31
TW200413388A (en) 2004-08-01
AR041231A1 (es) 2005-05-11
MY140442A (en) 2009-12-31
NO20051794L (no) 2005-04-12
RU2008129613A (ru) 2010-01-27
JP2006511469A (ja) 2006-04-06
ATE373663T1 (de) 2007-10-15
KR20050042500A (ko) 2005-05-09
CA2497119C (en) 2011-08-02
RU2005110925A (ru) 2006-01-20
PT1539768E (pt) 2007-12-17
GB0221312D0 (en) 2002-10-23
RU2343155C2 (ru) 2009-01-10
NZ538612A (en) 2008-01-31
CN1681824A (zh) 2005-10-12
DE60316456D1 (de) 2007-10-31
WO2004024735A3 (en) 2004-07-22
AU2003267349A1 (en) 2004-04-30
TWI289563B (en) 2007-11-11
AU2003267349B2 (en) 2008-05-01
WO2004024735A2 (en) 2004-03-25
SG155770A1 (en) 2009-10-29
CY1107794T1 (el) 2013-06-19
BR0314263A (pt) 2005-07-05
PL375039A1 (en) 2005-11-14
ECSP055652A (es) 2005-05-30
RU2404985C2 (ru) 2010-11-27
MXPA05002785A (es) 2005-06-03
PE20050052A1 (es) 2005-03-28
DE60316456T2 (de) 2008-06-19
US7470792B2 (en) 2008-12-30
CN100522968C (zh) 2009-08-05
EP1539768A2 (de) 2005-06-15

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