DK1539768T3 - Ny fremgangsmåde til fremstilling af epothilonderivater - Google Patents
Ny fremgangsmåde til fremstilling af epothilonderivaterInfo
- Publication number
- DK1539768T3 DK1539768T3 DK03748015T DK03748015T DK1539768T3 DK 1539768 T3 DK1539768 T3 DK 1539768T3 DK 03748015 T DK03748015 T DK 03748015T DK 03748015 T DK03748015 T DK 03748015T DK 1539768 T3 DK1539768 T3 DK 1539768T3
- Authority
- DK
- Denmark
- Prior art keywords
- new method
- epothilone derivatives
- preparing epothilone
- preparing
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0221312.2A GB0221312D0 (en) | 2002-09-13 | 2002-09-13 | Organic compounds |
| PCT/EP2003/010171 WO2004024735A2 (en) | 2002-09-13 | 2003-09-12 | A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1539768T3 true DK1539768T3 (da) | 2008-01-07 |
Family
ID=9944042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03748015T DK1539768T3 (da) | 2002-09-13 | 2003-09-12 | Ny fremgangsmåde til fremstilling af epothilonderivater |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7470792B2 (de) |
| EP (1) | EP1539768B1 (de) |
| JP (1) | JP4628102B2 (de) |
| KR (1) | KR20050042500A (de) |
| CN (1) | CN100522968C (de) |
| AR (1) | AR041231A1 (de) |
| AT (1) | ATE373663T1 (de) |
| AU (2) | AU2003267349B2 (de) |
| BR (1) | BR0314263A (de) |
| CA (1) | CA2497119C (de) |
| CY (1) | CY1107794T1 (de) |
| DE (1) | DE60316456T2 (de) |
| DK (1) | DK1539768T3 (de) |
| EC (1) | ECSP055652A (de) |
| ES (1) | ES2290489T3 (de) |
| GB (1) | GB0221312D0 (de) |
| HK (1) | HK1078853A1 (de) |
| IL (1) | IL166829A (de) |
| MX (1) | MXPA05002785A (de) |
| MY (1) | MY140442A (de) |
| NO (1) | NO20051794L (de) |
| NZ (1) | NZ538612A (de) |
| PE (1) | PE20050052A1 (de) |
| PL (1) | PL375039A1 (de) |
| PT (1) | PT1539768E (de) |
| RU (2) | RU2404985C2 (de) |
| SG (1) | SG155770A1 (de) |
| TW (1) | TWI289563B (de) |
| WO (1) | WO2004024735A2 (de) |
| ZA (1) | ZA200501008B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| EP1767535B1 (de) | 2002-08-23 | 2009-12-02 | Sloan-Kettering Institute For Cancer Research | Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung |
| CN103037903A (zh) | 2010-05-18 | 2013-04-10 | 天蓝制药公司 | 用于治疗自身免疫性疾病或其它疾病的组合物和方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6441186B1 (en) * | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| US6498257B1 (en) * | 1998-04-21 | 2002-12-24 | Bristol-Myers Squibb Company | 2,3-olefinic epothilone derivatives |
| GB9810659D0 (en) * | 1998-05-18 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
| EP1226142A2 (de) | 1999-07-22 | 2002-07-31 | Schering Aktiengesellschaft | Verfahren zur herstellung von epothiolon-b und derivaten davon, sowie von zwischenprodukten für dieses verfahren |
| US6593115B2 (en) * | 2000-03-24 | 2003-07-15 | Bristol-Myers Squibb Co. | Preparation of epothilone intermediates |
| US6989450B2 (en) * | 2000-10-13 | 2006-01-24 | The University Of Mississippi | Synthesis of epothilones and related analogs |
| JP2006505627A (ja) | 2002-07-31 | 2006-02-16 | シエーリング アクチエンゲゼルシャフト | 新規エフェクター接合体、それらの生成方法及びそれらの医薬使用 |
-
2002
- 2002-09-13 GB GBGB0221312.2A patent/GB0221312D0/en not_active Ceased
-
2003
- 2003-09-11 AR ARP030103290A patent/AR041231A1/es active IP Right Grant
- 2003-09-11 PE PE2003000922A patent/PE20050052A1/es not_active Application Discontinuation
- 2003-09-12 DK DK03748015T patent/DK1539768T3/da active
- 2003-09-12 EP EP03748015A patent/EP1539768B1/de not_active Expired - Lifetime
- 2003-09-12 DE DE60316456T patent/DE60316456T2/de not_active Expired - Lifetime
- 2003-09-12 TW TW092125250A patent/TWI289563B/zh not_active IP Right Cessation
- 2003-09-12 MX MXPA05002785A patent/MXPA05002785A/es active IP Right Grant
- 2003-09-12 BR BR0314263-9A patent/BR0314263A/pt not_active IP Right Cessation
- 2003-09-12 NZ NZ538612A patent/NZ538612A/en not_active IP Right Cessation
- 2003-09-12 SG SG200701814-6A patent/SG155770A1/en unknown
- 2003-09-12 RU RU2008129613/04A patent/RU2404985C2/ru not_active IP Right Cessation
- 2003-09-12 CN CNB038215837A patent/CN100522968C/zh not_active Expired - Fee Related
- 2003-09-12 AT AT03748015T patent/ATE373663T1/de active
- 2003-09-12 CA CA2497119A patent/CA2497119C/en not_active Expired - Fee Related
- 2003-09-12 ES ES03748015T patent/ES2290489T3/es not_active Expired - Lifetime
- 2003-09-12 WO PCT/EP2003/010171 patent/WO2004024735A2/en active Application Filing
- 2003-09-12 RU RU2005110925/04A patent/RU2343155C2/ru not_active IP Right Cessation
- 2003-09-12 PT PT03748015T patent/PT1539768E/pt unknown
- 2003-09-12 PL PL03375039A patent/PL375039A1/xx not_active Application Discontinuation
- 2003-09-12 US US10/526,283 patent/US7470792B2/en not_active Expired - Fee Related
- 2003-09-12 JP JP2004535499A patent/JP4628102B2/ja not_active Expired - Fee Related
- 2003-09-12 AU AU2003267349A patent/AU2003267349B2/en not_active Ceased
- 2003-09-12 KR KR1020057004237A patent/KR20050042500A/ko not_active Application Discontinuation
- 2003-09-13 MY MYPI20033494A patent/MY140442A/en unknown
-
2005
- 2005-02-03 ZA ZA200501008A patent/ZA200501008B/xx unknown
- 2005-02-10 IL IL166829A patent/IL166829A/en not_active IP Right Cessation
- 2005-03-09 EC EC2005005652A patent/ECSP055652A/es unknown
- 2005-04-12 NO NO20051794A patent/NO20051794L/no not_active Application Discontinuation
- 2005-11-24 HK HK05110670A patent/HK1078853A1/xx not_active IP Right Cessation
-
2007
- 2007-11-08 CY CY20071101447T patent/CY1107794T1/el unknown
-
2008
- 2008-08-01 AU AU2008203451A patent/AU2008203451A1/en not_active Abandoned
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