AU2002213977A1 - Novel anticholinergics, method for the production thereof and use thereof as medicaments - Google Patents

Novel anticholinergics, method for the production thereof and use thereof as medicaments

Info

Publication number
AU2002213977A1
AU2002213977A1 AU2002213977A AU1397702A AU2002213977A1 AU 2002213977 A1 AU2002213977 A1 AU 2002213977A1 AU 2002213977 A AU2002213977 A AU 2002213977A AU 1397702 A AU1397702 A AU 1397702A AU 2002213977 A1 AU2002213977 A1 AU 2002213977A1
Authority
AU
Australia
Prior art keywords
medicaments
production
anticholinergics
novel
novel anticholinergics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002213977A
Inventor
Helmut Meissner
Gerd Morschhauser
Michael Paul Pieper
Gerald Pohl
Richard Reichl
Georg Speck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
BOEHRINGER INGELHEIM PHARMA
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOEHRINGER INGELHEIM PHARMA, Boehringer Ingelheim Pharma GmbH and Co KG filed Critical BOEHRINGER INGELHEIM PHARMA
Publication of AU2002213977A1 publication Critical patent/AU2002213977A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
AU2002213977A 2000-10-14 2001-09-28 Novel anticholinergics, method for the production thereof and use thereof as medicaments Abandoned AU2002213977A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10050995A DE10050995A1 (en) 2000-10-14 2000-10-14 New benzylic acid azabicyclooctane ester quaternary salts useful as anticholinergic agents, especially in treatment of asthma and chronic obstructive pulmonary disease
DE10050995.9 2000-10-14
PCT/EP2001/011243 WO2002032898A2 (en) 2000-10-14 2001-09-28 Novel anticholinergics, method for the production thereof and use thereof as medicaments

Publications (1)

Publication Number Publication Date
AU2002213977A1 true AU2002213977A1 (en) 2002-04-29

Family

ID=7659809

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002213977A Abandoned AU2002213977A1 (en) 2000-10-14 2001-09-28 Novel anticholinergics, method for the production thereof and use thereof as medicaments

Country Status (8)

Country Link
EP (1) EP1328524B1 (en)
JP (1) JP5629420B2 (en)
AU (1) AU2002213977A1 (en)
CA (1) CA2425560C (en)
DE (1) DE10050995A1 (en)
MX (1) MXPA03003093A (en)
UY (1) UY26957A1 (en)
WO (1) WO2002032898A2 (en)

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US6706726B2 (en) 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
DE10200943A1 (en) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Process for the preparation of scopine esters
US7417051B2 (en) 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
DE10256317A1 (en) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Synergistic medicaments used for treating inflammaSynergistic medicaments used for treating inflammatory or obstructive respiratory tract diseases, cotory or obstructive respiratory tract diseases, contain quaternized scopine ester anticholinergic agntain quaternized scopine ester anticholinergic agent and beta-mimetic agent e.g. salmeterol salt ent and beta-mimetic agent e.g. salmeterol salt
MXPA04009916A (en) * 2002-04-12 2005-05-03 Boehringer Ingelheim Pharma Medicaments containing betamimetic drugs and a novel anticholinesterase drug.
DE602004021815D1 (en) * 2003-07-28 2009-08-13 Boehringer Ingelheim Pharma MEDICAMENTS FOR INHALATION WITH STEROIDS AND A NEW FLUORESCARBOXIC ACID ESTER
ES2316996T3 (en) * 2003-07-28 2009-04-16 Boehringer Ingelheim International Gmbh MEDICINES FOR INHALATION, UNDERSTANDING BETAMIMETICS AND AN ANTI-POLINERGIC AGENT.
EP1651224B1 (en) * 2003-07-31 2011-10-05 Boehringer Ingelheim International GmbH Medicaments for inhalation comprising an anticholinergic and a betamimetic
JP2007504123A (en) 2003-08-29 2007-03-01 ランバクシー ラボラトリーズ リミテッド Inhibitors of type IV phosphodiesterase
ATE547404T1 (en) 2003-09-22 2012-03-15 Msd Kk PIPERIDINE DERIVATIVES
TW200524577A (en) * 2003-11-04 2005-08-01 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
US7507745B2 (en) 2004-02-20 2009-03-24 Boehringer Ingelheim International Gmbh Pharmaceutical compositions based on fluorenecarboxylic acid esters and soluble TNF receptor fusion proteins
WO2005079794A1 (en) * 2004-02-20 2005-09-01 Boehringer Ingelheim International Gmbh Pharmaceutical compositions based on anticholinergics and pegsunercept
DE102004016179A1 (en) * 2004-03-30 2005-10-20 Boehringer Ingelheim Pharma Compounds for the treatment of proliferative processes
ES2322148T3 (en) * 2004-08-11 2009-06-17 BOEHRINGER INGELHEIM PHARMA GMBH &amp; CO. KG MEDICINES CONTAINING ANTI-POLINERGIC FOR TREATMENT IN URINARY ROADS.
WO2006025324A1 (en) * 2004-08-30 2006-03-09 Ono Pharmaceutical Co., Ltd. Tropan compound
EP1855689A1 (en) * 2005-02-16 2007-11-21 Boehringer Ingelheim International GmbH Pharmaceutical compositions comprising anticholinergics and etiprednol
WO2006094924A2 (en) * 2005-03-09 2006-09-14 Boehringer Ingelheim International Gmbh New pharmaceutical compositions based on anticholinergics and pde 5-inhibitors
CA2609429A1 (en) * 2005-05-31 2006-12-07 Boehringer Ingelheim International Gmbh Medicament containing a betamimetic in conjunction with an anticholinergic and a pde iv inhibitor
DE102005030733A1 (en) 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg New drug combinations for the treatment of respiratory diseases containing long-acting beta-2 agonists and at least one other active ingredient
EP1916239A4 (en) 2005-08-10 2009-10-21 Banyu Pharma Co Ltd Pyridone compound
BRPI0617674A2 (en) 2005-10-19 2011-08-02 Ranbaxy Lab Ltd pharmaceutical compositions and their uses
US7423146B2 (en) 2005-11-09 2008-09-09 Boehringer Ingelheim International Gmbh Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
US20070167480A1 (en) * 2005-12-19 2007-07-19 Sicor Inc. Pure and stable tiotropium bromide
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
CA2657639A1 (en) 2006-07-19 2008-01-24 Astrazeneca Ab Novel tricyclic spiropiperidine compounds, their synthesis and their uses as modulators of chemokine receptor activity
US20090324510A1 (en) 2006-08-07 2009-12-31 Boehringer Ingelheim International Gmbh Drug combinations for the treatment of respiratory tract diseases
PE20080610A1 (en) 2006-08-22 2008-07-15 Boehringer Ingelheim Int NEW ENANTHOMERICALLY PURE BETA-AGONISTS, PROCEDURES FOR THEIR PREPARATION AND USE AS MEDICINES
EP1905440A1 (en) * 2006-09-06 2008-04-02 Boehringer Ingelheim Pharma GmbH & Co. KG Use of a pharmaceutical composition comprising an anticholinergic for killing microorganisms and for treating respiratory tract infections
EP1958947A1 (en) 2007-02-15 2008-08-20 Ranbaxy Laboratories Limited Inhibitors of phosphodiesterase type 4
SI2124944T1 (en) 2007-03-14 2012-05-31 Ranbaxy Lab Ltd Pyrazolo?á3,4-b?åpyridine derivatives as phosphodiesterase inhibitors
EP2011538B1 (en) 2007-07-06 2016-02-17 Vectura Delivery Devices Limited Inhaler
US20100234411A1 (en) * 2007-07-18 2010-09-16 Boehringer Ingelheim Intermational Gmbh New Combination for the Treatment of Respiratory Diseases
EP2082771A1 (en) 2008-01-24 2009-07-29 Vectura Delivery Devices Limited Inhaler
EP2082772A1 (en) 2008-01-24 2009-07-29 Vectura Delivery Devices Limited Inhaler
EP2082768A1 (en) 2008-01-24 2009-07-29 Vectura Delivery Devices Limited Inhaler
EP2082767A1 (en) 2008-01-24 2009-07-29 Vectura Delivery Devices Limited Inhaler
EP2082766A1 (en) 2008-01-24 2009-07-29 Vectura Delivery Devices Limited Blister Strip Coil Forming
EP2093219A1 (en) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Crystalline enantiomer free salt form of a betamimetic and its use as medicine
EP2111861A1 (en) 2008-04-21 2009-10-28 Ranbaxy Laboratories Limited Compositions of phosphodiesterase type IV inhibitors
TW200951139A (en) 2008-05-27 2009-12-16 Astrazeneca Ab Chemical compounds 293
GB0918450D0 (en) 2009-10-21 2009-12-09 Innovata Ltd Composition
CN109020813A (en) * 2017-06-12 2018-12-18 北京大学 A kind of new method preparing alpha-brominated -3,4- dimethoxyphenylacetic acid ethapon ester
CN114702402B (en) * 2022-04-20 2024-01-30 诚达药业股份有限公司 Synthetic method of fluoro-phenyl amino acid hydrochloride

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DE1232157B (en) * 1963-05-29 1967-01-12 Verla Pharm Process for the preparation of benzilic acid tropine ester hydrochloride
LU60908A1 (en) * 1969-05-21 1970-07-16
DE2540633A1 (en) * 1975-09-12 1977-04-28 Boehringer Sohn Ingelheim NEW QUARTERLY N-BETA-SUBSTITUTED BENZILIC ACID-N-ALKYL-NORTROPINESTER AND PROCESS FOR THE PREPARATION
DE4108393A1 (en) * 1991-03-15 1992-09-17 Boehringer Ingelheim Kg NEW ESTERS BI-AND TRICYCLIC AMINO ALCOHOLS, THEIR PREPARATION AND THEIR USE IN MEDICINAL PRODUCTS
DE4200954A1 (en) * 1991-04-26 1992-10-29 Bayer Ag New heterocycle-substd. phenylacetic acid derivs. - are angiotensin II antagonists for treating arterial hypertonia, atherosclerosis, coronary insufficiency, ischaemic cerebral disorders, respiratory disorders, etc.
FR2677984B1 (en) * 1991-06-21 1994-02-25 Elf Sanofi N-SUBSTITUTED IMIDAZOLINE DERIVATIVES, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
JP3045819B2 (en) * 1991-07-17 2000-05-29 株式会社リコー Ink composition for inkjet recording
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Also Published As

Publication number Publication date
CA2425560C (en) 2008-07-15
EP1328524B1 (en) 2012-12-12
DE10050995A1 (en) 2002-04-18
JP5629420B2 (en) 2014-11-19
WO2002032898A2 (en) 2002-04-25
MXPA03003093A (en) 2005-06-30
JP2004511556A (en) 2004-04-15
EP1328524A2 (en) 2003-07-23
UY26957A1 (en) 2002-06-20
WO2002032898A3 (en) 2002-12-12
CA2425560A1 (en) 2003-04-11

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