ZA200409298B - Powder compaction and enrobing. - Google Patents
Powder compaction and enrobing. Download PDFInfo
- Publication number
- ZA200409298B ZA200409298B ZA200409298A ZA200409298A ZA200409298B ZA 200409298 B ZA200409298 B ZA 200409298B ZA 200409298 A ZA200409298 A ZA 200409298A ZA 200409298 A ZA200409298 A ZA 200409298A ZA 200409298 B ZA200409298 B ZA 200409298B
- Authority
- ZA
- South Africa
- Prior art keywords
- film
- powder
- slug
- forming
- Prior art date
Links
- 239000000843 powder Substances 0.000 title claims description 147
- 238000005056 compaction Methods 0.000 title description 25
- 238000000034 method Methods 0.000 claims description 74
- 239000002775 capsule Substances 0.000 claims description 73
- 239000000463 material Substances 0.000 claims description 30
- 238000005520 cutting process Methods 0.000 claims description 15
- 241000237858 Gastropoda Species 0.000 claims description 14
- 238000000576 coating method Methods 0.000 claims description 13
- 238000007666 vacuum forming Methods 0.000 claims description 11
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 7
- 239000000853 adhesive Substances 0.000 claims description 7
- 230000001070 adhesive effect Effects 0.000 claims description 7
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 6
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 6
- 108010010803 Gelatin Proteins 0.000 claims description 4
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 235000019322 gelatine Nutrition 0.000 claims description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 239000012815 thermoplastic material Substances 0.000 claims description 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 2
- 235000010469 Glycine max Nutrition 0.000 claims description 2
- 244000068988 Glycine max Species 0.000 claims description 2
- 108010046377 Whey Proteins Proteins 0.000 claims description 2
- 102000007544 Whey Proteins Human genes 0.000 claims description 2
- 229940072056 alginate Drugs 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000001814 pectin Substances 0.000 claims description 2
- 229920001277 pectin Polymers 0.000 claims description 2
- 235000010987 pectin Nutrition 0.000 claims description 2
- 235000018102 proteins Nutrition 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 235000021119 whey protein Nutrition 0.000 claims description 2
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims 1
- 229920000578 graft copolymer Polymers 0.000 claims 1
- 239000003826 tablet Substances 0.000 description 49
- 239000002552 dosage form Substances 0.000 description 12
- 239000011248 coating agent Substances 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 239000004014 plasticizer Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 210000001035 gastrointestinal tract Anatomy 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000002349 favourable effect Effects 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 235000013773 glyceryl triacetate Nutrition 0.000 description 3
- 239000001087 glyceryl triacetate Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 235000014655 lactic acid Nutrition 0.000 description 3
- 239000004310 lactic acid Substances 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 229960002622 triacetin Drugs 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229910000760 Hardened steel Inorganic materials 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000007894 caplet Substances 0.000 description 2
- 235000015872 dietary supplement Nutrition 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 108010025899 gelatin film Proteins 0.000 description 2
- 239000007902 hard capsule Substances 0.000 description 2
- WVDDGKGOMKODPV-UHFFFAOYSA-N hydroxymethyl benzene Natural products OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 2
- -1 hydroxypropyl Chemical group 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229920001169 thermoplastic Polymers 0.000 description 2
- 239000004416 thermosoftening plastic Substances 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 239000004348 Glyceryl diacetate Substances 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 239000006057 Non-nutritive feed additive Substances 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940061720 alpha hydroxy acid Drugs 0.000 description 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 230000001458 anti-acid effect Effects 0.000 description 1
- 230000003627 anti-cholesterol Effects 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 239000000989 food dye Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 235000019443 glyceryl diacetate Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 235000000396 iron Nutrition 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 239000004482 other powder Substances 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000009492 tablet coating Methods 0.000 description 1
- 238000009475 tablet pressing Methods 0.000 description 1
- 238000003856 thermoforming Methods 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000009966 trimming Methods 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/005—Coating of tablets or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
- B30B11/027—Particular press methods or systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0211620.0A GB0211620D0 (en) | 2002-05-21 | 2002-05-21 | Powder compaction and enrobing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200409298B true ZA200409298B (en) | 2005-09-05 |
Family
ID=9937076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200409298A ZA200409298B (en) | 2002-05-21 | 2004-11-18 | Powder compaction and enrobing. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7770361B2 (zh) |
| EP (1) | EP1505941A1 (zh) |
| JP (2) | JP4417246B2 (zh) |
| KR (3) | KR20080059474A (zh) |
| CN (1) | CN1671344A (zh) |
| AR (1) | AR039837A1 (zh) |
| AU (1) | AU2003227957A1 (zh) |
| BR (1) | BR0311321A (zh) |
| CA (1) | CA2486461A1 (zh) |
| GB (1) | GB0211620D0 (zh) |
| IL (1) | IL165251A0 (zh) |
| MX (1) | MXPA04011496A (zh) |
| PL (1) | PL374576A1 (zh) |
| RU (1) | RU2004137283A (zh) |
| TW (1) | TW200406192A (zh) |
| WO (1) | WO2003096963A1 (zh) |
| ZA (1) | ZA200409298B (zh) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003096976A2 (en) | 2002-05-14 | 2003-11-27 | Fmc Corporation | Microcrystalline cewllulose compositions |
| CN101065091A (zh) * | 2004-09-24 | 2007-10-31 | 生物进展技术有限公司 | 对粉末压实和包覆的额外改进 |
| EP1944005A3 (en) * | 2004-09-24 | 2008-07-23 | BioProgress Technology Limited | Additional improvements in powder compaction and enrobing |
| US8912908B2 (en) | 2005-04-28 | 2014-12-16 | Proteus Digital Health, Inc. | Communication system with remote activation |
| DK1889198T3 (da) | 2005-04-28 | 2015-02-09 | Proteus Digital Health Inc | Farma-informatiksystem |
| US8802183B2 (en) | 2005-04-28 | 2014-08-12 | Proteus Digital Health, Inc. | Communication system with enhanced partial power source and method of manufacturing same |
| US7879382B2 (en) * | 2005-09-30 | 2011-02-01 | Fmc Corporation | Stabilizers and compositions and products comprising same |
| JP2007117181A (ja) * | 2005-10-25 | 2007-05-17 | Nissei Kosan Kk | 軟質カプセル剤 |
| JP5173199B2 (ja) * | 2006-01-16 | 2013-03-27 | 株式会社アイ・ティー・オー | 創傷治癒用高分子組成物 |
| WO2008008120A1 (en) * | 2006-07-14 | 2008-01-17 | Fmc Corporation | Solid form |
| WO2008057267A2 (en) * | 2006-10-27 | 2008-05-15 | Fmc Corporation | Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations |
| US9078807B2 (en) * | 2007-02-16 | 2015-07-14 | Teijin Pharma Limited | Tablet compression machine |
| EP2063771A1 (en) | 2007-03-09 | 2009-06-03 | Proteus Biomedical, Inc. | In-body device having a deployable antenna |
| US20080286343A1 (en) * | 2007-05-16 | 2008-11-20 | Dzenana Cengic | Solid form |
| US20080311162A1 (en) * | 2007-05-16 | 2008-12-18 | Olivia Darmuzey | Solid form |
| MY154217A (en) | 2008-08-13 | 2015-05-15 | Proteus Digital Health Inc | Ingestible circuitry |
| TWI455733B (zh) | 2009-03-30 | 2014-10-11 | Toray Industries | 口腔內崩壞性被覆錠劑 |
| MX2011011506A (es) | 2009-04-28 | 2012-05-08 | Proteus Biomedical Inc | Marcadores de eventos ingeribles altamente confiables y metodos para utilizar los mismos. |
| TWI461213B (zh) | 2009-11-05 | 2014-11-21 | Fmc Corp | 作為藥物賦形劑之微晶纖維素及磷酸鈣之組合物 |
| TW201129386A (en) | 2009-11-05 | 2011-09-01 | Fmc Corp | Microcrystalline cellulose and calcium phosphate compositions useful as pharmaceutical excipients |
| CN102665764A (zh) | 2009-12-22 | 2012-09-12 | Fmc有限公司 | 可用作可再压实药物赋形剂的微晶纤维素和碳酸钙组合物 |
| KR20130045261A (ko) | 2010-04-07 | 2013-05-03 | 프로테우스 디지털 헬스, 인코포레이티드 | 소형의 섭취가능한 장치 |
| WO2012071280A2 (en) * | 2010-11-22 | 2012-05-31 | Proteus Biomedical, Inc. | Ingestible device with pharmaceutical product |
| US9756874B2 (en) | 2011-07-11 | 2017-09-12 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
| WO2015112603A1 (en) | 2014-01-21 | 2015-07-30 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
| CN103857739B (zh) | 2011-10-05 | 2017-04-19 | Fmc有限公司 | 共磨碎微晶纤维素和羧甲基纤维素的稳定剂组合物、制备方法和应用 |
| JP6188030B2 (ja) | 2011-10-05 | 2017-08-30 | エフ エム シー コーポレーションＦｍｃ Ｃｏｒｐｏｒａｔｉｏｎ | 微結晶セルロースおよびカルボキシメチルセルロースの安定化剤組成物、該組成物の製造方法並びに食品製品 |
| CN104010522A (zh) | 2011-12-09 | 2014-08-27 | Fmc有限公司 | 共磨碎稳定剂组合物 |
| JP2015534539A (ja) | 2012-07-23 | 2015-12-03 | プロテウス デジタル ヘルス， インコーポレイテッド | 摂取可能構成要素を備える摂取可能事象マーカーを製造するための技法 |
| CN104737532A (zh) | 2012-10-18 | 2015-06-24 | 普罗秋斯数字健康公司 | 用于适应性优化通信设备的电源中的功率耗散和广播功率的装置、系统和方法 |
| JP2016508529A (ja) | 2013-01-29 | 2016-03-22 | プロテウス デジタル ヘルス， インコーポレイテッド | 高度に膨張可能なポリマーフィルムおよびこれを含む組成物 |
| JP5941240B2 (ja) | 2013-03-15 | 2016-06-29 | プロテウス デジタル ヘルス， インコーポレイテッド | 金属検出器装置、システム、および方法 |
| US9796576B2 (en) | 2013-08-30 | 2017-10-24 | Proteus Digital Health, Inc. | Container with electronically controlled interlock |
| US10084880B2 (en) | 2013-11-04 | 2018-09-25 | Proteus Digital Health, Inc. | Social media networking based on physiologic information |
| CN104176285B (zh) * | 2014-08-08 | 2017-09-26 | 山东省泰安市农业机械科学研究所 | 全自动锥状物包装机 |
| US11051543B2 (en) | 2015-07-21 | 2021-07-06 | Otsuka Pharmaceutical Co. Ltd. | Alginate on adhesive bilayer laminate film |
| BR112019000861B1 (pt) | 2016-07-22 | 2020-10-27 | Proteus Digital Health, Inc | dispositivo eletrônico |
| JPWO2018074261A1 (ja) * | 2016-10-17 | 2019-08-22 | 第一三共株式会社 | 封入容器の製造方法及び製造装置 |
| KR102605670B1 (ko) | 2016-10-26 | 2023-11-24 | 오츠카 세이야쿠 가부시키가이샤 | 섭취 가능한 이벤트 마커를 갖는 캡슐을 제조하는 방법 |
| PL245095B1 (pl) * | 2020-07-27 | 2024-05-13 | Biotts Spółka Akcyjna | Sposób tabletkowania, urządzenie do tabletkowania oraz zestaw do tabletkowania |
| CN112549625B (zh) * | 2020-12-22 | 2022-07-22 | 新乡市常乐制药有限责任公司 | 一种枸橼酸西地那非片生产用的全自动成型制片机 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2663128A (en) * | 1948-03-23 | 1953-12-22 | American Cyanamid Co | Method and machine for making capsules |
| GB881022A (en) * | 1957-07-24 | 1961-11-01 | Maharaj Krishen Mehta | Improvements relating to methods and machines for forming and filling capsules of gelatine or like material |
| US4567714A (en) * | 1980-11-24 | 1986-02-04 | Chasman Sydney A | Method and apparatus for forming capsules |
| US5074102A (en) * | 1989-10-26 | 1991-12-24 | American Cyanamid Company | Flat track modified soft shell capsule filling machine |
| US5503673A (en) * | 1990-11-05 | 1996-04-02 | Mcneil-Ppc, Inc | Apparatus for dip coating product |
| US5616344A (en) * | 1994-06-14 | 1997-04-01 | Fuisz Technologies Ltd. | Apparatus and process for strengthening low density compression dosage units and product therefrom |
| JP3133899B2 (ja) * | 1994-07-07 | 2001-02-13 | 株式会社三共製作所 | 錠剤製造方法およびその装置 |
| US6245350B1 (en) * | 1994-12-16 | 2001-06-12 | Warner-Lambert Company | Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process |
| US5682733A (en) * | 1996-05-09 | 1997-11-04 | Perrone; Aldo | Apparatus for enrobing tablets |
| JP3092914B2 (ja) * | 1997-10-23 | 2000-09-25 | 株式会社イデアプランナーズ | 錠剤パック用オープナー |
| DE19941997A1 (de) * | 1999-09-02 | 2001-03-08 | Gunther Meinhardt Voss | Verfahren und Vorrichtung zur Herstellung einer Tablette o. dgl. |
| GB0113403D0 (en) | 2001-06-02 | 2001-07-25 | Bioprogress Tech Int Inc | Tablet enrobing |
| AU2002348884A1 (en) * | 2001-12-21 | 2003-07-09 | Pfizer Products Inc. | Directly compressible formulations of azithromycin |
-
2002
- 2002-05-21 GB GBGB0211620.0A patent/GB0211620D0/en not_active Ceased
-
2003
- 2003-05-19 CA CA002486461A patent/CA2486461A1/en not_active Abandoned
- 2003-05-19 KR KR1020087013258A patent/KR20080059474A/ko not_active Application Discontinuation
- 2003-05-19 AU AU2003227957A patent/AU2003227957A1/en not_active Abandoned
- 2003-05-19 CN CN03817463.4A patent/CN1671344A/zh active Pending
- 2003-05-19 KR KR1020087013257A patent/KR20080059473A/ko not_active Application Discontinuation
- 2003-05-19 WO PCT/GB2003/002145 patent/WO2003096963A1/en active Application Filing
- 2003-05-19 MX MXPA04011496A patent/MXPA04011496A/es not_active Application Discontinuation
- 2003-05-19 PL PL03374576A patent/PL374576A1/xx not_active Application Discontinuation
- 2003-05-19 IL IL16525103A patent/IL165251A0/xx unknown
- 2003-05-19 KR KR1020087013256A patent/KR20080059472A/ko not_active Application Discontinuation
- 2003-05-19 EP EP03725423A patent/EP1505941A1/en not_active Withdrawn
- 2003-05-19 JP JP2004504962A patent/JP4417246B2/ja not_active Expired - Fee Related
- 2003-05-19 RU RU2004137283/14A patent/RU2004137283A/ru not_active Application Discontinuation
- 2003-05-19 BR BR0311321-3A patent/BR0311321A/pt not_active IP Right Cessation
- 2003-05-19 US US10/515,415 patent/US7770361B2/en not_active Expired - Fee Related
- 2003-05-21 AR ARP030101770A patent/AR039837A1/es unknown
- 2003-05-21 TW TW092113689A patent/TW200406192A/zh unknown
-
2004
- 2004-11-18 ZA ZA200409298A patent/ZA200409298B/en unknown
-
2008
- 2008-09-30 JP JP2008254690A patent/JP2009007381A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009007381A (ja) | 2009-01-15 |
| EP1505941A1 (en) | 2005-02-16 |
| KR20080059472A (ko) | 2008-06-27 |
| MXPA04011496A (es) | 2005-07-01 |
| CA2486461A1 (en) | 2003-11-27 |
| US20050220824A1 (en) | 2005-10-06 |
| KR20080059473A (ko) | 2008-06-27 |
| KR20080059474A (ko) | 2008-06-27 |
| AU2003227957A1 (en) | 2003-12-02 |
| IL165251A0 (en) | 2005-12-18 |
| AR039837A1 (es) | 2005-03-02 |
| GB0211620D0 (en) | 2002-07-03 |
| TW200406192A (en) | 2004-05-01 |
| US7770361B2 (en) | 2010-08-10 |
| JP2005529645A (ja) | 2005-10-06 |
| PL374576A1 (en) | 2005-10-31 |
| JP4417246B2 (ja) | 2010-02-17 |
| BR0311321A (pt) | 2005-04-19 |
| RU2004137283A (ru) | 2005-10-27 |
| WO2003096963A1 (en) | 2003-11-27 |
| CN1671344A (zh) | 2005-09-21 |
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