ZA200408861B - Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor - Google Patents
Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor Download PDFInfo
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- ZA200408861B ZA200408861B ZA200408861A ZA200408861A ZA200408861B ZA 200408861 B ZA200408861 B ZA 200408861B ZA 200408861 A ZA200408861 A ZA 200408861A ZA 200408861 A ZA200408861 A ZA 200408861A ZA 200408861 B ZA200408861 B ZA 200408861B
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- spiro
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- ethyl
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- VVLMSCJCXMBGDI-UHFFFAOYSA-M trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium;iodide Chemical compound [I-].C[N+](C)(C)CC#CCN1CCCC1=O VVLMSCJCXMBGDI-UHFFFAOYSA-M 0.000 description 1
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- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
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US5407938A (en) | 1990-04-10 | 1995-04-18 | Israel Institute For Biological Research | Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines) |
US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
US6277874B1 (en) | 1996-07-09 | 2001-08-21 | University Of Cincinnati And Apologic, Incorporated | Methods for the treatment of apolipoprotein E related diseases |
TW453999B (en) * | 1997-06-27 | 2001-09-11 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
AU9454098A (en) | 1997-09-24 | 1999-04-12 | Nova Molecular, Inc. | Methods for increasing apoe levels for the treatment of neurodegenerative disease |
GB9916562D0 (en) * | 1999-07-14 | 1999-09-15 | Pharmacia & Upjohn Spa | 3-Arylsulfonyl-2-(substituted-methyl) propanoic acid derivatives as matrix metalloproteinase inhibitora |
DE19962543A1 (de) * | 1999-12-23 | 2001-07-05 | Degussa | Chromatographische Enantiomerentrennung von bicyclischen Lactamen |
-
2003
- 2003-05-01 KR KR1020047017640A patent/KR100998804B1/ko not_active IP Right Cessation
- 2003-05-01 NZ NZ536610A patent/NZ536610A/en not_active IP Right Cessation
- 2003-05-01 BR BRPI0309875-3A patent/BR0309875A/pt not_active IP Right Cessation
- 2003-05-01 EP EP03719064A patent/EP1507765A4/de not_active Withdrawn
- 2003-05-01 KR KR1020107013830A patent/KR101027570B1/ko not_active IP Right Cessation
- 2003-05-01 WO PCT/IL2003/000357 patent/WO2003092580A2/en active Application Filing
- 2003-05-01 MX MXPA04010921A patent/MXPA04010921A/es active IP Right Grant
- 2003-05-01 CA CA002484599A patent/CA2484599A1/en not_active Abandoned
- 2003-05-01 NZ NZ560368A patent/NZ560368A/en not_active IP Right Cessation
- 2003-05-01 AU AU2003223093A patent/AU2003223093B2/en not_active Ceased
- 2003-05-01 JP JP2004500765A patent/JP4584706B2/ja not_active Expired - Fee Related
- 2003-05-01 US US10/512,673 patent/US7439251B2/en not_active Expired - Fee Related
- 2003-05-01 CN CN038141337A patent/CN1662506A/zh active Pending
- 2003-05-02 TW TW092112152A patent/TWI330640B/zh not_active IP Right Cessation
- 2003-05-02 AR ARP030101533A patent/AR039965A1/es unknown
- 2003-05-02 US US10/429,277 patent/US7049321B2/en not_active Expired - Fee Related
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2004
- 2004-10-27 IL IL164857A patent/IL164857A/en not_active IP Right Cessation
- 2004-11-02 ZA ZA200408861A patent/ZA200408861B/en unknown
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2008
- 2008-06-12 US US12/138,261 patent/US20080306103A1/en not_active Abandoned
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2010
- 2010-06-04 JP JP2010128808A patent/JP4759649B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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WO2003092580A2 (en) | 2003-11-13 |
IL164857A0 (en) | 2005-12-18 |
CN1662506A (zh) | 2005-08-31 |
JP4759649B2 (ja) | 2011-08-31 |
KR100998804B1 (ko) | 2010-12-06 |
US20080306103A1 (en) | 2008-12-11 |
NZ536610A (en) | 2009-02-28 |
AU2003223093A1 (en) | 2003-11-17 |
MXPA04010921A (es) | 2005-05-27 |
JP2005530742A (ja) | 2005-10-13 |
WO2003092580A3 (en) | 2004-05-06 |
IL164857A (en) | 2010-12-30 |
JP2010184946A (ja) | 2010-08-26 |
NZ560368A (en) | 2008-11-28 |
BR0309875A (pt) | 2007-04-10 |
KR20100075700A (ko) | 2010-07-02 |
JP4584706B2 (ja) | 2010-11-24 |
KR101027570B1 (ko) | 2011-04-06 |
US20040044018A1 (en) | 2004-03-04 |
EP1507765A2 (de) | 2005-02-23 |
TW200404808A (en) | 2004-04-01 |
AU2003223093B2 (en) | 2010-02-04 |
US20060052406A1 (en) | 2006-03-09 |
TWI330640B (en) | 2010-09-21 |
WO2003092580B1 (en) | 2004-06-24 |
CA2484599A1 (en) | 2003-11-13 |
AR039965A1 (es) | 2005-03-09 |
US7439251B2 (en) | 2008-10-21 |
KR20050025168A (ko) | 2005-03-11 |
EP1507765A4 (de) | 2006-11-02 |
US7049321B2 (en) | 2006-05-23 |
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