ZA200407658B - Iron dextrin compounds for the treatment of iron deficiency anaemia - Google Patents
Iron dextrin compounds for the treatment of iron deficiency anaemia Download PDFInfo
- Publication number
- ZA200407658B ZA200407658B ZA200407658A ZA200407658A ZA200407658B ZA 200407658 B ZA200407658 B ZA 200407658B ZA 200407658 A ZA200407658 A ZA 200407658A ZA 200407658 A ZA200407658 A ZA 200407658A ZA 200407658 B ZA200407658 B ZA 200407658B
- Authority
- ZA
- South Africa
- Prior art keywords
- iron
- dextrin
- molecular weight
- daltons
- pharmaceutical composition
- Prior art date
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims description 191
- 239000004375 Dextrin Substances 0.000 title claims description 105
- 229920001353 Dextrin Polymers 0.000 title claims description 102
- 235000019425 dextrin Nutrition 0.000 title claims description 99
- 229910052742 iron Inorganic materials 0.000 title claims description 95
- 150000001875 compounds Chemical class 0.000 title claims description 37
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 title claims description 13
- 238000011282 treatment Methods 0.000 title claims description 12
- 239000000243 solution Substances 0.000 claims description 43
- 238000000034 method Methods 0.000 claims description 31
- 239000007864 aqueous solution Substances 0.000 claims description 23
- 239000008194 pharmaceutical composition Substances 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 19
- 229920002472 Starch Polymers 0.000 claims description 15
- 235000019698 starch Nutrition 0.000 claims description 15
- 239000008107 starch Substances 0.000 claims description 15
- 239000012528 membrane Substances 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 11
- 210000004379 membrane Anatomy 0.000 claims description 11
- 239000007924 injection Substances 0.000 claims description 10
- 238000002347 injection Methods 0.000 claims description 10
- IEECXTSVVFWGSE-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide Chemical compound [OH-].[O-2].[Fe+3] IEECXTSVVFWGSE-UHFFFAOYSA-M 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 8
- 241001465754 Metazoa Species 0.000 claims description 7
- 238000005984 hydrogenation reaction Methods 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 229960004887 ferric hydroxide Drugs 0.000 claims description 5
- 229910021519 iron(III) oxide-hydroxide Inorganic materials 0.000 claims description 5
- 239000011782 vitamin Substances 0.000 claims description 5
- 235000013343 vitamin Nutrition 0.000 claims description 5
- 229940088594 vitamin Drugs 0.000 claims description 5
- 229930003231 vitamin Natural products 0.000 claims description 5
- -1 cop- pcr Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000011321 prophylaxis Methods 0.000 claims description 4
- 239000003381 stabilizer Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- FYGDTMLNYKFZSV-MRCIVHHJSA-N dextrin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O[C@@H]1[C@@H](CO)OC(O[C@@H]2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-MRCIVHHJSA-N 0.000 claims description 3
- 235000016709 nutrition Nutrition 0.000 claims description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 2
- 125000003172 aldehyde group Chemical group 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 239000010941 cobalt Substances 0.000 claims description 2
- 229910017052 cobalt Inorganic materials 0.000 claims description 2
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 2
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- 150000001261 hydroxy acids Chemical class 0.000 claims description 2
- 239000006072 paste Substances 0.000 claims description 2
- 229910052711 selenium Inorganic materials 0.000 claims description 2
- 239000011669 selenium Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000011701 zinc Substances 0.000 claims description 2
- 229910052725 zinc Inorganic materials 0.000 claims description 2
- 239000002585 base Substances 0.000 claims 2
- 239000006185 dispersion Substances 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 claims 1
- 125000003158 alcohol group Chemical group 0.000 claims 1
- 239000003637 basic solution Substances 0.000 claims 1
- 239000000727 fraction Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical group Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 150000001720 carbohydrates Chemical class 0.000 description 7
- 239000002253 acid Substances 0.000 description 6
- 230000007062 hydrolysis Effects 0.000 description 6
- 238000006460 hydrolysis reaction Methods 0.000 description 6
- 230000029087 digestion Effects 0.000 description 5
- 229940082629 iron antianemic preparations Drugs 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 235000000346 sugar Nutrition 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000005194 fractionation Methods 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 208000003455 anaphylaxis Diseases 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 210000000936 intestine Anatomy 0.000 description 3
- 150000002506 iron compounds Chemical class 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 125000000075 primary alcohol group Chemical group 0.000 description 3
- 229910000033 sodium borohydride Inorganic materials 0.000 description 3
- 239000012279 sodium borohydride Substances 0.000 description 3
- 235000011121 sodium hydroxide Nutrition 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 150000008163 sugars Chemical class 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000002052 anaphylactic effect Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- FWZTTZUKDVJDCM-CEJAUHOTSA-M disodium;(2r,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;iron(3+);oxygen(2-);hydroxide;trihydrate Chemical compound O.O.O.[OH-].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[Na+].[Na+].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 FWZTTZUKDVJDCM-CEJAUHOTSA-M 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 235000001727 glucose Nutrition 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 229960001031 glucose Drugs 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 206010022971 Iron Deficiencies Diseases 0.000 description 1
- 206010065973 Iron Overload Diseases 0.000 description 1
- 241000192130 Leuconostoc mesenteroides Species 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 229930194936 Tylosin Natural products 0.000 description 1
- 239000004182 Tylosin Substances 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 238000011097 chromatography purification Methods 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 150000004695 complexes Chemical class 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 238000010981 drying operation Methods 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 229940032961 iron sucrose Drugs 0.000 description 1
- VRIVJOXICYMTAG-IYEMJOQQSA-L iron(ii) gluconate Chemical class [Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O VRIVJOXICYMTAG-IYEMJOQQSA-L 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 150000002482 oligosaccharides Polymers 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000036647 reaction Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229940083608 sodium hydroxide Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 125000003003 spiro group Chemical group 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 1
- 229960004059 tylosin Drugs 0.000 description 1
- 235000019375 tylosin Nutrition 0.000 description 1
- 239000004552 water soluble powder Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
- C08B30/12—Degraded, destructured or non-chemically modified starch, e.g. mechanically, enzymatically or by irradiation; Bleaching of starch
- C08B30/18—Dextrin, e.g. yellow canari, white dextrin, amylodextrin or maltodextrin; Methods of depolymerisation, e.g. by irradiation or mechanically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200200512 | 2002-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200407658B true ZA200407658B (en) | 2006-07-26 |
Family
ID=28459423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200407658A ZA200407658B (en) | 2002-04-09 | 2004-09-22 | Iron dextrin compounds for the treatment of iron deficiency anaemia |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20030191090A1 (ko) |
| EP (1) | EP1492821B1 (ko) |
| JP (1) | JP4520748B2 (ko) |
| KR (1) | KR20040104560A (ko) |
| CN (1) | CN1309741C (ko) |
| AR (1) | AR039396A1 (ko) |
| AT (1) | ATE335008T1 (ko) |
| AU (1) | AU2003226923B2 (ko) |
| BR (1) | BR0308773A (ko) |
| CA (1) | CA2480365A1 (ko) |
| DE (1) | DE60307249T2 (ko) |
| DK (1) | DK1492821T3 (ko) |
| EA (1) | EA006720B1 (ko) |
| ES (1) | ES2270070T3 (ko) |
| HK (1) | HK1069589A1 (ko) |
| MX (1) | MXPA04009770A (ko) |
| NO (1) | NO20044131L (ko) |
| NZ (1) | NZ535761A (ko) |
| PL (1) | PL373403A1 (ko) |
| PT (1) | PT1492821E (ko) |
| SI (1) | SI1492821T1 (ko) |
| UA (1) | UA79452C2 (ko) |
| WO (1) | WO2003087164A1 (ko) |
| ZA (1) | ZA200407658B (ko) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10249552A1 (de) | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| WO2005087216A2 (de) * | 2004-03-12 | 2005-09-22 | Eberhard-Karls-Universität Tübingen | Behandlung von anämischen zuständen durch inhibierung der erythrozytenapoptose |
| JP4550543B2 (ja) * | 2004-10-07 | 2010-09-22 | 松谷化学工業株式会社 | 鉄、マグネシウム又は亜鉛成分に対する食品用マスキング剤 |
| CA2597154C (en) | 2005-02-09 | 2011-03-15 | Vifor (International) Ag | Use of iron(iii) complex compounds |
| EP1757299A1 (de) | 2005-08-25 | 2007-02-28 | Vifor (International) Ag | Eisen(III)-Komplexverbindungen zur Behandlung von Eisenmangel-Zuständen bei Patienten mit chronisch-entzündlicher Darmerkrankung |
| EP1790356A1 (de) * | 2005-11-24 | 2007-05-30 | Vifor (International) Ag | Präparat, umfassend Eisen(III)-Komplexverbindungen und redoxaktive Substanz(en) |
| KR20080082674A (ko) | 2006-01-06 | 2008-09-11 | 루이트폴드 파머수티컬스, 인코퍼레이티드 | 철을 투여하기 위한 방법 및 조성물 |
| US20080132465A1 (en) * | 2006-12-05 | 2008-06-05 | Vincent Windisch | Apparatus and method for isolating iron components from serum |
| AU2009342799B2 (en) * | 2009-03-25 | 2014-12-18 | Pharmacosmos Holding A/S | A stable iron oligosaccharide compound |
| CN102451185A (zh) * | 2010-10-19 | 2012-05-16 | 长春纳米生技公司 | 金属离子纳米簇组合物 |
| WO2012104204A1 (en) | 2011-01-31 | 2012-08-09 | Vifor (International) Ag | Iron-carbohydrate complex compounds for the intravenous therapy of malaria |
| WO2013056085A1 (en) * | 2011-10-13 | 2013-04-18 | Vidasym, Inc. | Iron-fiber composition, preparation and uses thereof |
| CA2901018C (en) | 2013-03-08 | 2022-05-03 | Vidasym, Inc. | Metal ion-functional fiber component complex compositions, preparation and uses thereof |
| EP2997968A1 (en) | 2014-09-22 | 2016-03-23 | Ioulia Tseti | Iron (III) hydroxide complexes with activated glucose syrups and process for preparing same |
| US10258647B2 (en) | 2015-09-01 | 2019-04-16 | Particle Dynamics International, Llc | Iron-polysaccharide complexes and methods for the preparation thereof |
| WO2018198135A1 (en) * | 2017-04-26 | 2018-11-01 | Mylan Laboratories Ltd. | Improved process for the preparation of iron complex |
| CN107519198A (zh) * | 2017-07-21 | 2017-12-29 | 南通市第人民医院 | 一种右旋糖酐铁注射液及其制备方法 |
| EP3932535A1 (en) * | 2020-07-01 | 2022-01-05 | Vifor Fresenius Medical Care Renal Pharma, Ltd. | Manufacturing method for polynuclear iron compounds stabilized by carbohydrates and/or humic acid |
| EP4380581A1 (en) * | 2021-08-03 | 2024-06-12 | Pharmacosmos Holding A/S | Iron complex compounds for subcutaneous use in therapy of iron deficiency in companion animals |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1293144B (de) * | 1964-11-04 | 1969-04-24 | Hausmann Ag Labor | Verfahren zur Herstellung von Komplexverbindungen des Eisens mit Sorbit, Gluconsaeure und einem Oligosaccharid |
| GB1183940A (en) * | 1966-10-22 | 1970-03-11 | Fisons Pharmaceuticals Ltd | Ferric Hydroxide Complexes |
| ES360433A1 (es) * | 1968-11-20 | 1970-11-16 | Rocador Sa | Procedimiento para la fabricacion de un compuesto de hierrotrivalente apropiado para administracion por via oral. |
| US3686397A (en) * | 1970-05-18 | 1972-08-22 | Mueller Arthur | Parenteral iron preparations |
| JPS6039681B2 (ja) * | 1976-01-01 | 1985-09-07 | 日本臓器製薬株式会社 | デキストリン・クエン酸・第二鉄多核複合体及び該複合体を含有する非経口用鉄剤 |
| DE3422249A1 (de) * | 1984-06-15 | 1985-12-19 | Pfeifer & Langen, 5000 Köln | Wasserloesliches eisendextran und verfahren zu seiner herstellung |
| JPS6128502A (ja) * | 1985-04-06 | 1986-02-08 | Nippon Zoki Pharmaceut Co Ltd | デキストリン・ヒドロキシカルボン酸・第二鉄多核複合体の製造方法 |
| US4827945A (en) * | 1986-07-03 | 1989-05-09 | Advanced Magnetics, Incorporated | Biologically degradable superparamagnetic materials for use in clinical applications |
| US5102652A (en) * | 1986-07-03 | 1992-04-07 | Advanced Magnetics Inc. | Low molecular weight carbohydrates as additives to stabilize metal oxide compositions |
| DK172860B1 (da) * | 1998-03-25 | 1999-08-16 | Pharmacosmos Holding As | Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman |
-
2003
- 2003-04-08 NZ NZ535761A patent/NZ535761A/en not_active IP Right Cessation
- 2003-04-08 AT AT03746252T patent/ATE335008T1/de active
- 2003-04-08 MX MXPA04009770A patent/MXPA04009770A/es active IP Right Grant
- 2003-04-08 BR BR0308773-5A patent/BR0308773A/pt not_active IP Right Cessation
- 2003-04-08 PL PL03373403A patent/PL373403A1/xx unknown
- 2003-04-08 DK DK03746252T patent/DK1492821T3/da active
- 2003-04-08 DE DE60307249T patent/DE60307249T2/de not_active Expired - Lifetime
- 2003-04-08 SI SI200330490T patent/SI1492821T1/sl unknown
- 2003-04-08 PT PT03746252T patent/PT1492821E/pt unknown
- 2003-04-08 AR ARP030101220A patent/AR039396A1/es not_active Application Discontinuation
- 2003-04-08 AU AU2003226923A patent/AU2003226923B2/en not_active Ceased
- 2003-04-08 EA EA200401330A patent/EA006720B1/ru not_active IP Right Cessation
- 2003-04-08 KR KR10-2004-7015844A patent/KR20040104560A/ko not_active Application Discontinuation
- 2003-04-08 JP JP2003584119A patent/JP4520748B2/ja not_active Expired - Fee Related
- 2003-04-08 EP EP03746252A patent/EP1492821B1/en not_active Expired - Lifetime
- 2003-04-08 WO PCT/DK2003/000228 patent/WO2003087164A1/en active IP Right Grant
- 2003-04-08 CN CNB038079682A patent/CN1309741C/zh not_active Expired - Fee Related
- 2003-04-08 US US10/408,251 patent/US20030191090A1/en not_active Abandoned
- 2003-04-08 CA CA002480365A patent/CA2480365A1/en not_active Abandoned
- 2003-04-08 ES ES03746252T patent/ES2270070T3/es not_active Expired - Lifetime
- 2003-08-04 UA UA20041008114A patent/UA79452C2/uk unknown
-
2004
- 2004-09-22 ZA ZA200407658A patent/ZA200407658B/en unknown
- 2004-09-29 NO NO20044131A patent/NO20044131L/no not_active Application Discontinuation
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2005
- 2005-03-11 HK HK05102115A patent/HK1069589A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL373403A1 (en) | 2005-08-22 |
| WO2003087164A1 (en) | 2003-10-23 |
| CA2480365A1 (en) | 2003-10-23 |
| CN1309741C (zh) | 2007-04-11 |
| CN1646568A (zh) | 2005-07-27 |
| NO20044131L (no) | 2004-09-29 |
| DK1492821T3 (da) | 2006-11-27 |
| UA79452C2 (en) | 2007-06-25 |
| HK1069589A1 (en) | 2005-05-27 |
| DE60307249T2 (de) | 2007-03-15 |
| JP4520748B2 (ja) | 2010-08-11 |
| EA200401330A1 (ru) | 2005-02-24 |
| BR0308773A (pt) | 2005-02-09 |
| AU2003226923A1 (en) | 2003-10-27 |
| SI1492821T1 (sl) | 2006-12-31 |
| ES2270070T3 (es) | 2007-04-01 |
| EP1492821B1 (en) | 2006-08-02 |
| ATE335008T1 (de) | 2006-08-15 |
| EA006720B1 (ru) | 2006-04-28 |
| MXPA04009770A (es) | 2004-12-13 |
| AR039396A1 (es) | 2005-02-16 |
| DE60307249D1 (de) | 2006-09-14 |
| US20030191090A1 (en) | 2003-10-09 |
| EP1492821A1 (en) | 2005-01-05 |
| PT1492821E (pt) | 2006-12-29 |
| AU2003226923B2 (en) | 2006-08-17 |
| NZ535761A (en) | 2007-09-28 |
| KR20040104560A (ko) | 2004-12-10 |
| JP2005530863A (ja) | 2005-10-13 |
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