ZA200404997B - PiM-3 kinase as a target for type 2 diabetus melitus - Google Patents

PiM-3 kinase as a target for type 2 diabetus melitus Download PDF

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Publication number
ZA200404997B
ZA200404997B ZA200404997A ZA200404997A ZA200404997B ZA 200404997 B ZA200404997 B ZA 200404997B ZA 200404997 A ZA200404997 A ZA 200404997A ZA 200404997 A ZA200404997 A ZA 200404997A ZA 200404997 B ZA200404997 B ZA 200404997B
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ZA
South Africa
Prior art keywords
pim
protein
seq
polypeptide
activity
Prior art date
Application number
ZA200404997A
Other languages
English (en)
Inventor
Marcus Korn
Guenter Mueller
Rudolf Schneider
George Tschank
Original Assignee
Sanofi Aventis Deutschland
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Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of ZA200404997B publication Critical patent/ZA200404997B/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200404997A 2002-01-19 2004-06-24 PiM-3 kinase as a target for type 2 diabetus melitus ZA200404997B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02001401 2002-01-19

Publications (1)

Publication Number Publication Date
ZA200404997B true ZA200404997B (en) 2006-05-31

Family

ID=8185311

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200404997A ZA200404997B (en) 2002-01-19 2004-06-24 PiM-3 kinase as a target for type 2 diabetus melitus

Country Status (14)

Country Link
EP (1) EP1468092B1 (zh)
JP (1) JP4272533B2 (zh)
KR (2) KR101205194B1 (zh)
CN (1) CN100467601C (zh)
AT (1) ATE541040T1 (zh)
BR (1) BR0306984A (zh)
CA (2) CA2680946C (zh)
DK (1) DK1468092T3 (zh)
IL (1) IL194074A (zh)
MX (1) MXPA04006906A (zh)
NO (1) NO333253B1 (zh)
RU (1) RU2316598C2 (zh)
WO (1) WO2003060130A2 (zh)
ZA (1) ZA200404997B (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1661990A4 (en) * 2003-08-11 2006-08-23 Kureha Corp Liver-cancer-specific polypeptide, the polypeptide-encoding polynucleotide, and the expression of the polypeptide-inhibiting RNA molecule
WO2020262983A1 (ko) * 2019-06-27 2020-12-30 전북대학교 산학협력단 신규한 에이디피-라이보실 사이클라아제 및 이의 저해제

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0911391A3 (en) * 1997-10-24 2000-01-19 Smithkline Beecham Corporation A clone HWHHJ20
US6143540A (en) * 1999-01-26 2000-11-07 Millennium Pharmaceuticals, Inc. Molecules of the HKID-1-related protein family and uses thereof
CN1328134A (zh) * 2001-04-13 2001-12-26 复旦大学 一种蛋白激酶编码序列,其编码的多肽、制法及用途
DE10123055A1 (de) * 2001-05-11 2003-03-20 Gruenenthal Gmbh Screeningverfahren mit PIM1-Kinase oder PIM3-Kinase

Also Published As

Publication number Publication date
CA2473566A1 (en) 2003-07-24
JP2005514068A (ja) 2005-05-19
NO20043459L (no) 2004-10-07
CN100467601C (zh) 2009-03-11
MXPA04006906A (es) 2004-12-06
RU2316598C2 (ru) 2008-02-10
AU2003202579A1 (en) 2003-07-30
BR0306984A (pt) 2004-12-14
EP1468092B1 (en) 2012-01-11
ATE541040T1 (de) 2012-01-15
CA2680946C (en) 2013-03-12
CN1620505A (zh) 2005-05-25
KR20040075940A (ko) 2004-08-30
KR101205194B1 (ko) 2012-11-27
CA2473566C (en) 2012-05-01
CA2680946A1 (en) 2003-07-24
KR101158326B1 (ko) 2012-06-28
IL194074A (en) 2011-08-31
NO333253B1 (no) 2013-04-22
WO2003060130A3 (en) 2004-01-15
WO2003060130A2 (en) 2003-07-24
DK1468092T3 (da) 2012-05-07
RU2004125291A (ru) 2005-04-20
KR20110011753A (ko) 2011-02-08
EP1468092A2 (en) 2004-10-20
JP4272533B2 (ja) 2009-06-03

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