KR20050115436A - 우울증 치료에 사용되는 '반복적 경두개 자기장 법'에 의하여 발현이 변화되는 흰쥐 뇌의 해마 유전자군. - Google Patents
우울증 치료에 사용되는 '반복적 경두개 자기장 법'에 의하여 발현이 변화되는 흰쥐 뇌의 해마 유전자군. Download PDFInfo
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Abstract
본 발명은 우울증의 치료방법으로 사용되고 있는 '반복적 경두개 자기장 자극법 (repetitive transcranial magnetic stimulation; rTMS)'의 치료 효과를 분자수준에서 규명하고자, cDNA 마이크로어레이 (microarray)를 이용하여 검색된 유전자 군을 제공한다. 또한, 정상동물에게 rTMS이 미치는 영향을 유전자 군으로 제공하며, 우울증 모델 제작을 위하여 정상 흰쥐에게 적용된 '경미한 만성적 스트레스 법 (chronic mild stress; CMS)'이 미치는 영향을 유전자 군으로 제공한다.
본 발명의 방법으로는, 4주 동안 흰쥐에게 인위적인 우울증을 유도하고, 우울증 유도가 확인된 흰쥐에게 만성적인 rTMS을 처치한다. 2주간의 rTMS 처치가 완료된 흰쥐의 해마 (hippocampus)로부터, 유전자의 발현 양상을 cDNA 마이크로어레이를 이용하여 검색하였다. 유전자의 발현 양상은 3개의 그룹 (정상 흰쥐 對 우울증 모델, 허위 (sham) rTMS-정상흰쥐 對 rTMS-정상 흰쥐, 허위 (sham) rTMS-우울증 모델 對 rTMS-우울증 모델)에서 비교 분석하였다.
정상흰쥐와 우울증 모델간의 발현차이가 있는 유전자 군을 분류하고, 정상 흰쥐에게 영향을 주는 rTMS 관련 유전자 군, 우울증 모델에게 영향을 주는 rTMS 관련 유전자 군을 분류하였다. 분석된 결과는 rTMS의 우울증 치료 효과를 분자수준에서 규명하는데 응용하며, 나아가 우울증 진단 및 치료를 위한 생물학적 지표 (biomarker)로 응용 가능하다.
Description
'반복적 경두개 자기장 자극법 (repetitive transcranial magnetic stimulation; rTMS; 이하 'rTMS'로 표기)'을 처치한 우울증 모델의 해마로부터 검색된 유전자 군을 제시하고, 제시된 유전자 군은 우울증 진단 및 치료을 위한 생물학적 지표로 응용하기 위함이다.
본 발명은 '경미한 만성적 스트레스 (chronic mild stress ; CMS; 이하 'CMS'로 표기)'로 4주 동안 흰쥐에게 우울증을 유도하고, 상기의 방법에 의해 우울증이 유도된 흰쥐에게 rTMS을 2주간 수행한 후, 그 흰쥐 뇌의 해마 (hippocampus)로 부터 메신져 RNA를 추출하여 cDNA 마이크로어레이에 적용하는 것이다. 상기의 방법을 통하여 우울증 관련 유전자군, rTMS에 의해 영향을 받은 정상흰쥐와 우울증 모델의 해마 유전자 군을 분류한다. 검색된 유전자 군으로부터 rTMS의 항우울능을 분자수준에서 규명하기 위한 유전자 군 및 그 서열을 제공한다.
우울증은 감정, 인지, 자율신경계와 내분비계의 기능이상에 연관된 심각한 심적 질환이다. 우울증의 정확한 발병 원인은 밝혀지지 않았지만, 일반적으로 중추 신경계의 시냅스 (synapse)내에 모노아민계 (monoamine) 신경전달물질 (neurotransmitter)의 부족으로 나타난다고 알려져 있다 (참조; Manji HK, Drevets WC, Charney DS. Nat Med. 2001 May 7, 541-7.). 모노아민계 신경 전달 물질로는 세로토닌 (serotonine), 노르에피네프린 (norepineprine), 도파민 (dopamine)등이 있다. 기존의 우울증 치료 약물은 시냅스 내의 위와 같은 신경전달물질의 농도를 높여주는 약리작용을 가지고 있다. 대표적으로, 선택적 세로토닌 재흡수 억제제 (selective serotonin reuptake inhibitor)는 가장 일반적으로 사용되는 약물이다. 이 외에도 삼환계 항우울제 (TCA; tricyclic antidepressan), MAO 억제제 (MAOI; monoamine oxidase inhibitors)등이 있다. 그러나 우울증 환자들의 20 %정도는 위와 같은 항우울제로 치료가 되지 않기도 하며, 비만, 성욕감퇴 등의 부작용이 보고되고 있다. 또한, 약물의 효과가 2~3주 후에 나타나기도 하여 우울증으로 인한 자살율의 감소에도 기존의 항우울제는 기여를 못하고 있는 실정이다. 상기와 같은 약물치료의 단점을 보완하는 전기충격요법 (electroconvulsive therapy; ECT)은 임상적인 효과는 우수하나, 고통과 일시적 기억 상실 등의 단점이 있다.
신경정신과 질환에 적용된 rTMS은 환자의 두부표면에서 한 전류에 의해 생성된 자기장이 뇌의 신경세포 분극화에 영향을 주는 장치이다 (아래).
rTMS가 우울증 환자의 전두엽에 처리되었을 때, 뇌의 직접적인 손상과 고통 없이 임상적으로 긍정적인 영향을 주는 것으로 보고되고 있다 (참조; George, M. S., E. M. Wassermann, W. A. Williams, J. Steppel, A. Pascual-Leone, P. Basser, M. Hallett and R. M. Post (1996). J. Neuropsychiatry Clin. Neurosci. 8, 172-180.). Ben-Shachar 등 (참조; Ben-Shachar, D. H., Gazawi, J., Riboyad-Levin, E. K. (1999).Brain Res. 816, 78-83.)은 정상 흰쥐에게 rTMS를 가했을 때 뇌에서의 베타-아드레날린 수용기와 5-하이드록시트립타민 (hydroxytryptamine; HT) 수용기의 변화를 측정하였으며, rTMS의 한 회기 (session)가 흰쥐의 뇌에서 선택적이고 특이한 모노아민계 수준 (level) 전환 (turnover)에 영향을 주는 것을 확인하였다. Kole 등 (참조; Kole, M. H., E. Fuchs, U. Ziemann, W. Paulus and U. Ebert (1999). Brain Res. 826, 309-312.)은 5-HT1A와 N-메틸-D-아스파테이트 (NMDA)의 결합부위의 변화를 측정하였다. 또한, Hausmann 등 (참조; Hausmann, A., C. Weis, J. Marksteiner, H. Hinterhuber and C. Humpel (2000).Brain Res. Mol. Brain Res. 76, 355-362.)은 rTMS가 뇌의 해마등에서 c-fos 발현과 mRNA 생성에 미치는 영향을 보고하였다. 몇 몇의 rTMS에 의한 분자수준의 연구가 보고되고 있지만, 대부분의 실험이 정상 흰쥐와 정산 인에게 처치된 결과를 보여주고 있다. rTMS가 임상적으로 항우울능을 부여한다고 할지라도, rTMS의 분자수준의 뇌 기제 (機制) 연구가 부족한 실정이다. 실제로, 기준이 정해지지 않은 rTMS의 사용은 예상하지 못한 부정적인 결과도 보고하고 있다 (참조; E.M. Schuman, Electroencephalogr. Clin. Neurophysiol. 1998, 108, 1-16.).
우울증 환자의 경우, 학습능력과 기억력등을 제어하는 뇌기관 (器官)인 해마 (hippocampus)의 크기가 작아지며, 그 신경세포는 세포사멸 (apoptosis)이 이루어 졌음이 보고되고 있다 (참조; Lucassen PJ, Fuchs E, Czeh B. Biol Psychiatry. 2004 Apr 15, 789-96.). 세포사멸은 손상된 세포나, 원하지 않는 세포가 만들어진 경우, 세포 스스로 죽음을 택하는 것으로써 상당히 조직적으로 이루어지며 에너지가 요구되는 과정이다.
현재는 우울증에 대한 분자 수준의 이해 없이, 기존의 항우울제들이 BDNF (brain derived neurotrophic factor)등의 유전자의 발현을 증가시키는 것으로 보고하고 있다. BDNF는 신경가소성 (neuroplasticity)등을 증가시키는 것으로 잘 알려진 유전자이다 (참조; Chen, B., D. Dowlatshahi, G. M. MacQueen, J. F. Wang and L. T. Young. 2001. 50, 260-265.).
이러한 문제점을 인식하고 영국 등 10여 개국이 지난 30년 동안 큰 진척이 없었던 우울증 치료제나 치료 법를 공동 개발하는 ‘NEWMOOD’라는 프로젝트를 개시하였다 (참조 Nature. April. news). 이 프로젝트는 세계적으로 1억 2000만명으로 추산되는 우울증 환자의 치료를 위해 신약개발은 물론, 우울증의 원인과 진단 및 치료 등에 임상적으로 응용 가능한 유전자/단백질 수준의 기초자료를 제공 할 것이라고 기대하고 있다. 프로젝트 연구팀은 쥐를 대상으로 우울증을 유발하는 유전자로 추정되고 있는 800여 개의 후보 유전자를 마이크로칩으로 제작하여 유전자 차원에서 이들 유전자의 세포내의 대사과정과 성장과정 등을 연구하고 있다. 즉, 이번 연구의 최종 목표는 마이크로칩을 우울증 진단 및 치료에 이용한다는 계획이다. 그러나, 상기의 프로젝트는 현재 우울증 진단 및 치료를 위한 관련 유전자에 대한 보고가 없는 실정이다.
상기에 서술된 바와 같이, 효과적인 우울증의 치료는 분자수준에서의 우울증 이해가 선행되어야 한다. 우울증의 뇌 기제 (機制)에 대한 정확한 이해는 우울증의 진단 및 치료을 위한 정확한 약물표적인자를 제공할 수 있다.
본 발명은 우울증과 관련되는 유전자 군을 제시하여 우울증의 진단 및 치료에 응용하기 위함이 그 목적이다. 또한, 임상적으로 항우울제로 사용되고 있는 rTMS의 효과를 분자수준에서 규명하기 위하여 정상 흰쥐와 우울증 흰쥐에게 rTMSD을 각각 처치하여 그 영향을 유전자 군으로 제공 하고자 한다.
구체적으로는, 우울증을 인위적으로 유도한 흰쥐의 해마에서 우울증 관련 유전자를 cDNA 마이크로 어레이를 이용하여 제공한다. 정상 흰쥐에게 rTMS을 처치하여 rTMS 자체의 영향을 cDNA 마이크로 어레이를 이용하여 유전자 군으로 제공한다. 선행되어진 우울증 모델에게 rTMS을 처치하여, rTMS의 항우울능을 cDNA 마이크로 어레이를 이용하여 유전자 군으로 제공한다.
본 발명에서 제공된 유전자 군으로 우울증의 뇌 기제 (機制)를 분자수준에서 이해하고, rTMS의 영향을 분자수준에서 이해하고, rTMS의 항우울능을 분자수준에서 이해한다. 제공된 유전자 군으로부터 우울증의 기제 (機制)를 이해하고, rTMS의 항우울능을 분자수준에서 이해한다. 또한, 제공된 유전자 군은 우울증 진단 및 치료을 위한 생물학적지표로 응용될 수 있으며, 나아가 30년 동안 변하지 않은 항우울제에 대항하는 신 항우울제 개발을 위한 기초자료로 응용 가능하다.
본 발명은 rTMS의 항우울능을 분자수준에서 이해하고자 3개의 실험 군을 구성하였다.
첫 번째 실험 군으로, 정상 흰쥐와 우울증 모델을 비교하였다.
우울증 모델은 CMS를 인위적으로 흰쥐에게 처리하는 것으로서 제작되었다. 본 발명에서 수행된 방법은 1992년 Willner의 방법을 재구성 한 것이다 (참조 Willner, P., R. Muscat and M. Papp. Neurosci. Biobehav. Rev. 1992, 16, 525-534.). 자세한 방법은 '실시예) 1'에 기술하였다. CMS 모델은 우울증의 잘 인식된 모델이다 (참조 Willner, Paul, Psycopharmacology,1997,134,319-329.).
두 번째 실험 군으로, 정상 흰쥐에게 허위 rTMS를 처치한 것과 rTMS를 처치한 것을 비교하였다. 허위 rTMS는 정상 흰쥐에게 rTMS 장치를 하고, 소리만 들려주어 직접적인 자기장에 영향을 받지 않는다. 두 번째 실험 군은 rTMS의 영향을 확인하기 위한 것이다.
세 번째 실험 군으로, 우울증 모델에게 허위 rTMS를 처치한 것과 rTMS를 처치한 것을 비교하였다. 세 번째 실험 군은 rTMS의 항우울능을 확인하기 위한 것이다.
이하, 본 발명을 실시 예에 의해서 상세 설명한다.
실시예 1)CMS에 의한 우울증 모델 제작
수컷 흰쥐 (wistar rat; 약 225g)는 빛이 조절되는 사육실 (9:00 a.m. 소등, 9:00 p.m. 점등)에서 2주간 환경적응을 시킨 후, 다음과 같은 처치를 하였다. Willner가 도입했던 스트레스 항목 중 추위와 냄새자극에 대한 노출을 제외한 나머지 스트레스 항목이 동일하게 적용되도록 하였다. 스트레스는 2회의 백색소음 (8시간, 9시간), 3회의 섬광 제시 (9시간, 9시간, 5시간), 1회의 16시간 동안의 물 박탈과 뒤이어 제시되는 1시간 동안의 빈 병 노출, 2회의 케이지 기울이기 (7시간, 8시간), 1회의 17시간 동안의 3배수 집단 사육, 2회의 물 먹이 박탈 (20시간, 24시간)과 이후 2시간 동안의 먹이제한, 24시간 주기 역전, 1회의 젖은 케이지 (9시간)이 포함된다. CMS 절차는 4주간 진행되었으며, 우울증 유도의 정도는 1 % 자당 섭취량에 의해 측정하였다.
실시예 2) rTMS의 처치
우울증 모델은 2주간의 rTMS (Neopulse stimulator; Neotonus) 처치를 수행받았다. 그 내용을 간단히 서술하면, 10 Hz로 5초 동안 처리하고, 25초 동안 쉬는 것을 한 절차로 하여 10분간 처리함으로서 하루에 1000번의 자기장을 느끼도록 하였고, rTMS 처리는 오후 2시에 수행하였다. 허위 rTMS은 흰쥐를 rTMS 장치에 고정한 상태에서 rTMS의 녹음된 소리만을 들려주어 자기장의 영향은 받지 않도록 하였다. 마지막 처리를 하고 2시간 후에 해마를 추출하였다.
실시예 3) 전체 RNA의 추출
전체 RNA는 Trizol (Invitrogen 사.)을 이용하여 제공되는 방법으로 분리하였다. 모든 실험기구들은 RNA 분해효소 억제제를 처리하거나 0.1 % Diethyl pryrocarbonate (DEPC) 용액에 하루 동안 처리하고 멸균하여 사용하였다. 흰쥐의 뇌로부터 해마를 추출하여 -70 ℃ 에서 냉동보관 후 실험직전, 막자 사발을 이용하여 잘게 파쇄 하였다. 파쇄된 조직은 Trizol 5 ml에 녹이고, 이중 200 ㎕을 다시 Trizol 1 ml에 희석하였다. 희석된 샘플은 와류 (voltexing)하여 세포 파괴를 유도 하고, 200 ㎕의 클로로포롬을 첨가하여 다시 한번 와류하였다. 와류시킨 샘플은 15,000 rpm에서 15분간 4 ℃에서 원심분리 한 뒤, 상층 액을 새 튜브로 옮겨 클로로포롬 반응을 한번 더 반복하였다. RNA를 포함한 상층 액은 1 ml의 이소 프로필기 알코올과 혼합하여 1시간 이상 -20 ℃에 방치한 후 15,000 rpm에서 15분간 4 ℃에서 원심분리 하였다. 육안으로 RNA 응집 체를 확인하고 상층 액을 조심스럽게 제거하였다. 75 % 에탄올 (DEPC + 에탄올), 1 ml을 첨가하고 15,000 rpm에서 15분간 4 ℃에서 원심분리 하였다. 상층 액을 제거하고 에탄올이 완전히 제거될 때까지 상온에 방치 하였다. DEPC로 처리된 증류수를 사용하여 전체 RNA를 녹이고 흡광광도계 (spectrophotometer)에서 RNA의 순수도와 그 양을 확인하였다 (아래).
그림설명 : 상기의 그림은 흰쥐의 해마로부터 분리되어진 전체 RNA를 아가로즈겔에 전기영동 한 사진이다.
1 번 : 정상 흰쥐 해마의 전체 RNA
2 번 : 우울증 모델 해마의 전체 RNA
3 번 : 허위 rTMS를 처치한 정상 흰쥐 해마의 전체 RNA
4 번 : rTMS를 처치한 정상 흰쥐 해마의 전체 RNA
5 번 : 허위 rTMS를 처치한 우울증 모델 흰쥐 해마의 전체 RNA
6 번 : rTMS를 처치한 우울증 모델 흰쥐 해마의 전체 RNA
실시예 4) 마이크로어레이와 분석
각 그룹의 기준 (정상흰쥐, 허위 rTMS-정상흰쥐, 허위 rTMS-우울증 모델)과 비교대상 (우울증 모델, rTMS-정상흰쥐, rTMS-우울증 모델) 각각에 amino-allyl cDNA labeling kit (Ambion)를 사용하여 각각 Cy3 /Cy5 (형광물질)로 표시하는 것으로 탐침 (probe)을 준비하였다. 준비된 탐침은 멸균수, 8 μg의 poly (dA) (Pharmacia), 4 μg의 Escherichia coli tRNA (Sigma)와 10 μg의 mouse Cot1 DNA (Gibco BRL)를 혼합하여 총 60 ㎕가 되도록 하였다. 95 °C 에서 5분간 처리하고, Genetaq automatic hybridizer (Genomic Solution)를 사용하여 52 °C에서 8시간 동안 혼성 (hybridization)한 후에 칩은 세척 액 Ⅰ (2 X SSC, 0.2 % SDS)로 52 °C에서 5분간 씻어주었다. 연속적으로 세척 액 Ⅱ (0.1 X SSC, 0.2 % SDS)로 52 °C에서 5분간, 그리고 세척 액 Ⅲ (0.1 X SSC)로 5분간 실온에서 반응시켰다. 슬라이드는 3분 동안 스캔 (Affymatrix; GMS 418 Array Scanner) 하였다. 상기와 같은 방법으로 3개의 실험군 마다 4번 반복된 cDNA 마이크로어레이 결과는 Log 2값으로 환산하여, Lowess smoothing 에 의하여 표준화를 수행하였다. 표준화를 거친 결과는 Significant analysis of Microarray (SAM; t-statistics) 프로그램을 이용하여 반복 실험간의 표준화로 통계적으로 유의하게 증가 또는 감소하는 유전자를 최종적으로 검색하였다 (표1~3).
그림 설명 : 상기의 그림은 '실시 예 3'에 설명되어진 방법으로 마이크로어레이를 수행한 것이다. 세로축은 다양한 유전자를 나타낸다. 각 3개의 실험 군에서 기준이 되는 RNA에 초록색 형광물질을 붙이고, 비교대상이 되는 RNA에 붉은색 형광물질을 붙이고 혼성 (hybridization)시키면, 발현정도에 따라 상대적으로 붉은색/초록색을 갖게된다. 상기의 그림은 DNA 칩 위에 배열된 유전자들과 상보성을 갖는 RNA가 우울증 모델에서 덜 발현되어 붉은색으로 표시되지 않은 것을 보여준다.
1 번 : 정상 흰쥐 對 우울증 모델
2 번 : 허위 rTMS을 처치한 정상 흰쥐 對 rTMS을 처치한 정상 흰쥐
3 번 : 허위 rTMS을 처치한 우울증 모델 對 rTMS을 처치한 우울증 모델
| 유전자 이름 | 유니진 번호 | 발현비율 |
| A kinase anchor protein 8 | Rn.10248 | -0.532518925 |
| Hypothetical LOC288921 (LOC288921), mRNA | Rn.29201 | -0.540408575 |
| RAP1B, member of RAS oncogene family | Rn.95071 | -0.5643418125 |
| uterine sensitization-associated gene 1 | Rn.2415 | -0.57563515 |
| insulin-like growth factor binding protein 2 | Rn.6813 | -0.59712765 |
| protein phosphatase 2A B regulatory subunit delta isoform | Rn.8898 | -0.6765256 |
| Hypothetical LOC292596 (LOC292596), mRNA | Rn.92802 | -0.7753533025 |
| insulin-like growth factor 2 | Rn.964 | -0.79183395 |
| transient receptor potential cation channel, subfamily V, member 1 | Rn.3073 | -1.02992745 |
| ectonucleotide pyrophosphatase/phosphodiesterase 2 | Rn.20403 | -1.031013275 |
| murine thymoma viral (v-akt) oncogene homolog 2 | Rn.87066 | -1.105227375 |
| granulin | Rn.5820 | -1.1514185 |
| interleukin 15 | Rn.2490 | -1.31317925 |
| transthyretin | Rn.1404 | -1.480745 |
| 유전자 이름 | 유니진 번호 | 발현비율 |
| CUG triplet repeat,RNA-binding protein 2 | Rn.30004 | 0.54606375 |
| macrophage galactose N-acetyl-galactosamine specific lectin | Rn.779 | 0.58816315 |
| small inducible cytokine A5 | Rn.8019 | 0.59516635 |
| CL1BA protein | Rn.10776 | 0.59617285 |
| heterogeneous nuclear ribonucleoproteins methyltransferase-like 2 (S. cerevisiae) | Rn.5870 | 0.60323485 |
| Rattus norvegicus similar to NADH dehydrogenase (ubiquinone) flavoprotein 1 (LOC293655), mRNA | Rn.3159 | 0.52172075 |
| 유전자 이름 | 유니진번호 | 발현비율 |
| neurochondrin | Rn.5653 | -0.5879506 |
| kinase D-interacting substance of 220 kDa | Rn.16792 | -0.50874455 |
| complement component 1, s subcomponent | Rn.4037 | 0.50142435 |
| Rattus norvegicus putative G-protein coupled receptor RA1c mRNA, complete cds | Rn.12541 | 0.50856025 |
| Slc38a2: Solute carrier family 38, member 2 | Rn.16393 | 0.51005495 |
| mitogen-activated protein kinase 12 | Rn.42944 | 0.5165711 |
| sodium channel, voltage-gated, type 1, beta polypeptide | Rn.4958 | 0.5193979 |
| nucleophosmin 1 | Rn.54537 | 0.5311268 |
| cysteine-sulfinate decarboxylase | Rn.43232 | 0.53297775 |
| Add3: Adducin 3, gamma | Rn.76589 | 0.53502 |
| CCAAT/enhancerbinding, protein (C/EBP) delta | Rn.6975 | 0.5459838 |
| Protein tyrosine kinase | Rn.2809 | 0.5750168 |
| HLA-B-associated transcript 3 | Rn.22304 | 0.596235 |
| interleukin 1 receptor-like 1 | Rn.10072 | 0.5975174 |
| 17-beta hydroxysteroid dehydrogenase type 2 | Rn.10515 | 0.59986505 |
| mannosidase, alpha, class 2C, member 1 | Rn.11301 | 0.60774165 |
| general transcription factor III C 1 | Rn.11288 | 0.6082875 |
| Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor) | Rn.10148 | 0.6231105 |
| Albumin | Rn.34353 | 0.64091475 |
| Rattus norvegicus retinoblastoma-associated protein mRNA, 3' end | Rn.55115 | 0.6656547 |
| zinc finger protein 179 | Rn.7544 | 0.7279068 |
| actin alpha cardiac 1 | Rn.3114 | 0.8194069 |
| protein phosphatase 2A B regulatory subunit delta isoform | Rn.8898 | 0.83578915 |
| Orosomucoid 1 | Rn.10295 | 0.92037355 |
| Abcc5a: ATP-binding cassette, sub-family C (CFTR/MRP), member 5a | Rn.9491 | 1.0440232 |
| granulin | Rn.5820 | 1.605823 |
기술한 바와 같이, 본 발명은 마이크로어레이를 이용하여 rTMS의 항우울능을 분자수준에서 규명하고자 3개의 실험군의 관련 유전자를 동시에, 신속하게 검색하였다. 상기 방법에 의해 검색된 유전자 군은 우울증의 뇌 기제 (機制) 이해를 증진시키고, rTMS의 분자 기제 (機制) 이해를 증진시킨다. 궁극적으로는 우울증 치료를 위한 최적의 약물개발 및 장치개발로 응용하기 위한 기초 자료로서 응용 가능하다.
<110> KIM, Eun Ah
CHAI, Young Gyu
<120> differentially expressed genes in hippocampus of rat brain
affected by repetitive transcranial magnetic stimulation that
used to the therapy for major depression
<150> 10-2004-0040139
<151> 2004-06-02
<160> 44
<170> KopatentIn 1.71
<210> 1
<211> 4311
<212> DNA
<213> Rattus norvegicus
<400> 1
atgaaggata ttgacatggg aaaagaatac atcatcccca gtcccggata cagaagcgtc 60
agggacagaa gcactatccc gggacaacac ggcgatcgtg aagaacccag gttccggaga 120
acaagatcat tggaatgcca agatgcccta gaaacagcag cccgagttga gggtctttcc 180
ctggacatct ctgtgcattc tcatctccaa attctggacg aggaacatac gaaggggaaa 240
taccaccatg gtttaagcgc cctgaagccc ttccggacca ccaccaagca ccagcaccca 300
gtggacaatg ctggcctttt ctcctacatg accttttcat ggctctctcc tctggcccaa 360
gtggttcaca agaaggggga gctgttaatg gaggatgtgt ggcctttgtc caagtatgag 420
tcttctgatg tgaactgcag aagactagag agactgtggc aagaagagct gaatgaagtc 480
gggccagacg ccgcctccct gcgaagggtt gtgtggatct tttgccgcac caggctcatc 540
ctgtccatcg tgtgcctgat gatcacgcag ttggctggct tcagtggacc agccttcgtg 600
gtgaagcacc tcttggagta cacccaggca acagagtcta acctgcagta cagcttgctg 660
ttggtactag gcctcctcct gacagaggtt gtacgctcct ggtcactcgc actgacttgg 720
gcattgaatt atcgcactgg tgtccggctg cggggggctg tcctgaccat ggcattcaag 780
aagatcctga agctaaagaa cattaaggaa aagtccctgg gggagcttat caatatctgc 840
tccaacgatg ggcagaggat gtttgaagca gccgctgtgg gcagcttgct ggccggagga 900
cccgttgtcg ccatcttggg catgatttat aatgtaatca ttctaggacc aacgggcttc 960
ctgggatcgg ctgtctttat cctcttttat ccggcaatga tgttcgtgtc acggctaacc 1020
gcgtatttca ggagaaagtg tgtagccgcc acagacgacc gtgtccagaa gatgaatgaa 1080
gttcttacct acattaaatt tattaaaatg tatgcctggg tcaaagcgtt ttctcagtgt 1140
gttcaaaaaa tccgagagga ggagcgtcgg atcctggaga aggccgggta ctttcagagc 1200
atcaccgttg gagtggctcc cattgtcgta gtgatcgcca gcgtggtgac gttctccgtc 1260
cacatgaccc tgggcttcga cctgacagcg gcgcaggcct tcacagtggt gactgtcttc 1320
aattccatga cttttgcttt aaaagtaaca ccattctcag tgaagtccct ctctgaagca 1380
tccgttgctg ttgacagatt taagagtttg tttctaatgg aagaggttca catgataaag 1440
aacaaaccgg ccagtcctca catcaagata gagatgaaaa atgccacctt ggcatgggac 1500
tcctcccact ccagtacaca gagctcgccc aagctgaccc ccaaagtgaa aaaagacaag 1560
agggctccca agggcaagaa agagaagtcg aggcagctgc aacatactga gcaccaggcg 1620
gtgctggcag agcagaaagg acacctcctc ctggacagtg atgagcggcc cagtccggaa 1680
gaggaagaag gcaagcagat ccacgcaggg agcatgcgtc tgcagaggac actctacaac 1740
attgacttag agattgaaga gggcaaactg gttggaatct gtggcagtgt gggaagtgga 1800
aaaacctctc tgatttccgc cattttaggc cagatgacgc ttttggaggg cagcattgcc 1860
gtcagtggga cctttgctta cgtggcccaa caggcctgga ttctcaacgc cacgctgaga 1920
gacaacattc tctttgggaa ggaatttgat gaagagagat acaactcagt gctgaacagt 1980
tgctgcctgc ggcctgactt ggccattctc cccaacagcg acctgactga gattggagag 2040
cgaggagcca acctgagtgg tgggcagcgc cagcgaatca gccttgctcg agccctgtac 2100
agtgacagaa gcatctatat cttggatgat cccctcagtg ccttagatgc ccatgtgggc 2160
aaccacatct tcaacagtgc tatccggaag cgtctcaagt ctaagacggt cctgtttgtc 2220
acacaccagt tacagtacct ggtcgattgt gatgaggtga tcttcatgaa agaaggctgt 2280
atcacagaga gaggtaccca cgaggagctg atgaacttaa atggagacta cgctaccatt 2340
tttaataacc tgttgctggg agagacaccc ccggtcgaga ttaattcaaa aaaggaagct 2400
agtggttcac aaaaatcaca agacaagggc cctaagccag ggtcagtgaa gaaggagaag 2460
gcagtgaagt cggaggaagg gcagctcgtg caggtggagg agaaagggca gggctccgtg 2520
ccttggtcag tttactgggt ctacatccag gctgcagggg gtcccttggc tttcctggtc 2580
atcatggtcc tcttcatgct caatgtgggc agcactgcct tcagcacctg gtggctaagc 2640
tactggatca agcaaggaag cgggaacagc acggtgtttg aagggaacag aagctctgtg 2700
agtgacagca tgagggacaa ccccttcctg cagtactatg ccagcatcta cgctctctcc 2760
atggcagtca tgctgatcct gaaggccatc cgaggagttg tctttgtcaa gggtacactg 2820
agagcctcct cccggctcca tgatgagctc ttccggagga tcctgagaag ccccatgaag 2880
ttttttgata ctaccccaac aggaaggatt ctcaacaggt tttccaaaga catggatgaa 2940
gtggacgtgc gtctgccatt ccaggctgag atgtttatcc agaatgtgat cctggtgttc 3000
ttctgtgttg gaatgatcgc aggggtcttc ccatggttcc ttgtggcagt ggggcctctc 3060
ctcatcctct tctcagttct acacattgtc tccagggtcc tgattcggga gctgaagcgc 3120
ttggacaata tcacgcaatc tcctttcctc tcccatatca cgtccagcat tcagggcctc 3180
gccaccatcc atgcctataa caaaaggcag gagtttctac acaggtatca ggagcttctg 3240
gatgacaacc aagccccctt cttcttgttc acctgtgcaa tgaggtggct ggcagtgcgg 3300
ctggacctca tcagcatcgc cctgatcacc accacggggc tcatgattgt tctcatgcac 3360
gggcagatcc cttcagcgta cgcgggcctc gccatctcct acgctgtgca gttaaccgga 3420
ctcttccagt ttaccgttag actggcgtcg gagacagaag cacggttcac ctcagtggag 3480
aggatcaacc actacataaa gactctctct ttggaagcac ctgccagaat caagaacaag 3540
gctcctcccc atgactggcc ccaggaggga gaaataacct ttgagaatgc ggaaatgaga 3600
taccgggaaa atctccctct ggtccttaag aaagtgtcct tcaccatcaa gcccaaggaa 3660
aagataggca ttgtgggacg aacagggtca gggaagtcct ctctagggat ggccctcttc 3720
cgcctggtgg agttatctgg aggctgcatc aagatcgatg gagtaagaat cagtgacatt 3780
ggcctggccg acctccgaag caaactgacc atcatccctc aggagccagt gctgttcagc 3840
ggcacagtca gatcaaacct ggaccctttc aaccagtaca cagaagagca gatctgggat 3900
gccctagaga gaacacacat gaaggaatgt attgcccagc tacctctgaa actggaatct 3960
gaagtaatgg agaacgggga caacttctct gttggggaac ggcagttgtt atgcatagca 4020
agggccctgc tacgtcactg taagattctg attttagatg aagctacagc cgctatggac 4080
acagagacag acttactgat ccaagagacc atccgggaag catttgctga ctgcaccatg 4140
ctgaccattg cccatcgcct gcacacagtt ctgggctctg ataggatcat ggtgctggcc 4200
cagggacagg tggtggagtt tgacaccccg tcggtccttc tgtccaacga cagctcaaga 4260
ttctatgcca tgtgtgctgc tgcagagaac aaggtggctg tcaagggctg a 4311
<210> 2
<211> 2016
<212> DNA
<213> Rattus norvegicus
<400> 2
atgagttcag acagcagcca agcggtgatc accacccctc ctcctcccag catgcctcac 60
aaagagaggt attttgaccg aatcaatgaa agtgatccag aatacctccg agagaggaac 120
atgtctcctg atctacggga ggacttcaat atgatggagc agaggaagcg agtcactcag 180
atcctgcaga gtcctgcctt tcgggaagac ctagagtgcc tcacccaaga acagatgaag 240
aaaggccacg acccgaccgg attgctagcg ttacagcaga tcgccgacta catcatggcc 300
aactccttca ccggtttttc ttcacctccc ctgagtcttg gcatggtcac tcctattaat 360
gaccttcctg gtgcagacac atcctcgtat gtgaagggag agaagctcac tcgttgcgaa 420
ctcgccagcc tgtacagact cgcagatctg tttgggtggg cacatctggc aaatacatac 480
atctcggtac gagtaagtaa ggagcaggac cacatcataa tcatccccag aggcctccct 540
ttctctgaag ccacagcctc tgctctggtg aaggtcaaca taataggaga agtggtggac 600
caggggagta ctaatttgaa aattgaccat tcaggattca gtccccatgc tgcaatctat 660
tcaacccgtc ccgatgtgaa gtgtgtgata cacatccaca ccctcgctac agcagctgtg 720
tcttccatga agtgtgggat ccttccaatt tcccaagagt ctctcatcct gggagatgta 780
gcctattatg actaccaggg gtcgcttgat gaggaggagg aaagaatcga acttcagaaa 840
gttctgggtc caagctgtaa ggtgctggtc ctcaggaacc atggcgtggt agctcttgga 900
gaaacacttg aggaggcttt ccactacatc ttcaatgtac agatggcctg tgagattcag 960
gtgcaggctg tagcaggggc agggggagtg gacaatcttc tcatactgga tcttcagaaa 1020
tacaaagctt tcacccacgg tgttgccatg actggaggag gcggtgtgaa tatgggttcc 1080
catcagaagt ggaaagttgg cgagattgag tttgaagggc tcatgagaac cctggacaac 1140
ttgggctaca gaacaggcta cgcatacagg catcctctag ttcgagagaa gcctcggcac 1200
aagagtgacg tggagatccc agcaactgtg actgcattct cctttgaaga tgatagtgtg 1260
ccactctctc ccctcaagta catggcacag agacagcagc gtgaaaaaac aagatggctg 1320
aattctccaa atacatacat gaaagtgaat gtgccggagg agtcccggaa cggggaaact 1380
agtcccagga ccaaaataac gtggatgaaa gcagaggacc cctctaaagt tagtagtgga 1440
acacctatca aaattgaaga tcccaatcag tttgttcctc taaacacgaa cccgactgag 1500
gtgctggaga agagaaataa gattcgggaa cagaatcgct atgacctgaa gacagcaggg 1560
ccacagtctc agctgctggc ggggatcgtt gtggacaaac cgccttctac catgcggttt 1620
gaagacgatg atcagggccc accagcccct cctaacccat tcagtcatct catggaagga 1680
gaacttgaag aatatacgaa gacaatcgag agacagcagc aaggcctgga cgaaaaccac 1740
gagctgtttt ccaagagctt cacctctgtg gatgtgcctg tcattgtgaa tggcaaggac 1800
gagatgcacg atgttgaaga cgagctcgct cagcgcgtca gcaggctcac gacgagcacc 1860
accatagaga acatcgagat caccatcaag tccccagaca gaactgaaga ggtcctgtca 1920
cccgatggct cgccttcaaa gtcaccatcc aagaaaaaga agaaattccg cacaccttct 1980
tttctcaaaa agaacaaaaa aaaaggagaa agttga 2016
<210> 3
<211> 1827
<212> DNA
<213> Rattus norvegicus
<400> 3
atgaagtggg taacctttct cctcctcctc ttcatctccg gttctgcctt ttctaggggt 60
gtgtttcgcc gagaagcaca caagagtgag atcgcccatc ggtttaagga cttaggagaa 120
cagcatttca aaggcctagt cctgattgcc ttttcccagt atctccagaa atgcccatat 180
gaagagcata tcaaattggt gcaggaagta acagactttg caaaaacatg tgtcgctgat 240
gagaatgccg aaaactgtga caagtccatt cacactctct tcggagacaa gttatgcgcc 300
attccaaagc ttcgtgacaa ctacggtgaa ctggctgact gctgtgcaaa acaagagccc 360
gaaagaaacg agtgtttcct gcagcacaag gatgacaacc ccaacctgcc acccttccag 420
aggccggagg ctgaggccat gtgcacctcc ttccaggaga accctaccag ctttctggga 480
cactatttgc atgaagttgc caggagacat ccttatttct atgccccaga actcctttac 540
tatgctgaga aatacaatga ggttctgacc cagtgctgca cagagtctga caaagcagcc 600
tgcctgacac cgaagcttga tgccgtgaaa gagaaagcac tggtcgcagc tgtccgtcag 660
aggatgaagt gctccagtat gcagagattt ggagagagag ccttcaaagc ctgggcagta 720
gctcgtatga gccagagatt ccccaatgct gagttcgcag aaatcaccaa attggcaaca 780
gacgttacca aaatcaacaa ggagtgctgt cacggcgacc tgttggaatg cgcggatgac 840
agggcagaac ttgccaagta catgtgtgag aaccaggcca ctatctccag caaactgcag 900
gcttgctgtg ataagccagt gctgcagaaa tcccagtgtc tcgctgagac agaacatgac 960
aacattcctg ccgatctgcc ctcaatagct gctgactttg ttgaggataa ggaagtgtgt 1020
aagaactatg ctgaggccaa ggatgtcttc ctgggcacgt ttttgtatga atattcaaga 1080
aggcaccccg attactccgt gtccctgctg ctgagacttg ctaagaaata tgaagccaca 1140
ctggagaagt gctgtgctga aggcgatcct cctgcctgct acggcacagt gcttgcagaa 1200
tttcagcctc ttgtagaaga acctaagaac ttggtcaaaa ctaactgtga gctttacgag 1260
aagcttggag agtatggatt ccaaaacgcc gttctggttc gatacaccca gaaagcacct 1320
caggtgtcga ccccaactct cgtggaggca gcaagaaacc tgggaagagt gggcaccaag 1380
tgttgtaccc ttcctgaagc tcagagactg ccctgtgtgg aagactatct gtctgccatc 1440
ctgaaccgtc tgtgtgtgct gcatgagaag accccagtga gcgagaaggt caccaagtgc 1500
tgtagtgggt ccttggtgga aagacggcca tgtttctctg ctctgacagt tgacgagaca 1560
tatgtcccca aagagtttaa agctgagacc ttcaccttcc actctgatat ctgcacactc 1620
ccagacaagg agaagcagat aaagaagcaa acggctctcg ctgagctggt gaaacacaag 1680
cccaaggcca cagaagatca gctgaagacg gtgatgggtg acttcgcaca attcgtggac 1740
aagtgttgca aggctgccga caaggataac tgcttcgcca ctgaggggcc aaaccttgtt 1800
gctagaagca aagaagcctt agcctaa 1827
<210> 4
<211> 3297
<212> DNA
<213> Rattus norvegicus
<400> 4
atggagccta atgatagtac cagtaccgct gtggaggagc ctgacagctt ggaggtgttg 60
gtgaagacct tggactctca aactcgtacc tttattgtgg gggcccagat gaatgtaaaa 120
gagtttaagg agcacattcg tgcctctgtc agcatcccat ctgaaaaaca acggctcatt 180
taccagggac gagttctgca agatgataag aagcttcagg aatacaatgt tgggggaaag 240
gttatccacc tggtggaacg ggctcctcct cagactcacc tcccttctgg ggcatcttct 300
gggacggggt ctgcctcagc tactcatggt gggggcccct gccctggcac tcggggccct 360
ggggcctctg gtcatgaccg gaatgccaac agttatgtca tggttggaac cttcaatctt 420
cctagtgacg gctctgctgt ggacgttcac atcaacatgg aacaggcccc aattcagagt 480
gagccccggg tacggctggt gatggctcag cacatgatta gggatataca gaccttactg 540
tcccggatgg agtgtcgagg ggggaaccaa gcacaggcca gtcagccacc cccgcagact 600
ccgactgtgg cctcagagac agtagctttg aactcacaaa catcagagcc agtcgaaagt 660
gaagctcctc ctcgagagcc catggagtca gaagaaatgg aggaacgtcc cccaacccag 720
actccagagc ttccaccctc tggcccagct ccagcaggcc cagcacccgc accagagaca 780
aatgcaccca cccaaccttc ccctgcagag cacgtggagg tgctccagga gcttcagcgc 840
ttgcaacgcc gtcttcagcc cttcctgcag cgctactgtg aggtcctggg tgctgctgcc 900
actacagact acaataacaa tcatgagggc cgagaagagg accagaggtt gattaacttg 960
gtgggggaga gcctgcggct actgggcaac actttcgtgg cattgtctga tctgcgctgt 1020
aatctagcct gtgcaccccc acggcacctg catgtggtac ggcctatgtc tcactacacg 1080
actcccatgg tgctccagca ggcagccatt cccattcaga tcaatgtggg gactactgtg 1140
accatgacag gcaatggggc tcggcctcca ccagctcccg gtgcagaggc agcatcccca 1200
ggttctggcc aggcctcatc ccttcctcca tcttctgcca ctgttgattc atcaacggaa 1260
ggagctcccc caccagggcc agcaccacca ccagccacca gccatccacg ggtcatccgg 1320
atttctcacc agagtgtgga acctgtggtc atgatgcaca tgaacattca agactccgga 1380
gcacagcctg gaggtgtgcc cagtgctccc actggccccc tgggacctcc tggtcatgga 1440
cagagcctgg gacagcaggt gcccggcttc ccaacagcac caactcgggt ggtgattgcc 1500
cgacccactc ctccacaggc tcggccttcc catcctgggg gccctccagt ctctggagct 1560
ctaggtgctg ggctgggtac aaacacttca ttggcccaga tggtgagcgg ccttgtgggg 1620
cagcttctta tgcagccagt ccttgtggct caggggaccc caggaatggc tccggcttct 1680
gcttcagctc cggctacggc acaggcacag gcccaggccc cggccccagc cccagctccg 1740
gccccagctc cagccactgc ttcagctagt gctggcacta ccaacacagc caccacagcc 1800
ggccctgctc ctgggggtcc cgcccagcct ccacctcctc agccctctgc ggctgatctt 1860
cagttctctc agctcctggg aaatctgctg gggcctgcag ggccaggggc tggggggcca 1920
agcctggctt ctcccaccat cactgtggca gtgcctggag ttcctgcttt tctccagggc 1980
atgactgagt ttttgcaggc atcacaggct gcccctccac cccctccacc tcctccaccc 2040
ccacctcctg ctccagagca gcagaccaca ccacctccag gatccccttc tggtgggaca 2100
gcgagtcctg ggggcttagg tcctgagagc ctgccaccag agtttttcac ctcagtggtg 2160
cagggcgtgt tgagctccct cctgggctcc ttgggggctc gtgctggcag cagtgagagt 2220
attgctgcct tcatccaacg cctcagtgga tccagcaaca tctttgagcc tggggctgat 2280
ggcgcccttg gattctttgg agctctgctc tctcttctgt gccagaattt ctccatggtg 2340
gatgtggtga tgcttctcca tggccatttc cagccactac agcggctcca gccacagcta 2400
cgatctttct tccaccagca ctacctgggt ggccaggagc ccacgtccag caacatccgg 2460
atggcaaccc acacgttgat cacggggctg gaagagtatg tacgggagag tttctctttg 2520
gtgcaggttc agccaggtgt ggatatcatc cggacaaatt tagaatttct ccaggagcaa 2580
tttaacagca ttgctgctca cgtgctgcac tgtacagaca gtggatttgg agcccggctg 2640
ctggagctat gtaaccaggg cctgtttgaa tgcttggccc tgaacctgca ctgcttgggg 2700
ggccagcaaa tggagcttgc tgctgtcatc aatggccgaa ttcgccgcat gtctcgtggg 2760
gtgaatccat ccttggtgag ctggctgaca actatgatgg gactcaggct tcaggtggtc 2820
ttagagcaca tgcccgtggg tcccgacgcc atcctcagat atgtgcgcag gattggtgat 2880
cctcctcagg cacttcctga agagccaatg gaagttcagg gagcagaaag aacttcccct 2940
gagcctcaga gagaagatgc ttccccagcc cctggaacaa cagcagaaga agccatgtcc 3000
cgaggtccac cccctgctcc tgaaggaggt tcccgagacg aacaggatgg agcttcagcc 3060
gatgcagagc cctgggcagc tgcagtcccc cctgaatggg tacctattat ccagcaggac 3120
attcagagcc agcggaaggt gaaacctcag ccgcccctga gtgatgccta cctcagtggc 3180
atgcctgcca agagacgaaa gctccggtct gatattcaaa aacgactgca ggaagatccc 3240
aactacagcc cccagcgctt ccctaatgcc caccgggcat ttgctgatga cccctag 3297
<210> 5
<211> 2085
<212> DNA
<213> Rattus norvegicus
<400> 5
atgggcaaat cgccagagat gtggtgcttt gtcttctttt ctcttttggc atcgttttct 60
gctgagccta ccatgtatgg ggagatcctg tcccctaatt atccccaggc gtaccccaat 120
gaggtcgtga aaacttggga catagaagtc ccagaggggt ttgggattca cctttacttc 180
acccatctgg acatggagct gtcagagaac tgtgcatacg actcagtgca gataatctca 240
ggaggtatcg aggaagagag actctgtggc cagaggtcca gcaagagtcc caactccccc 300
actgtagaag agtttcaatt cccatacaat aggctccagg tggtctttac gtcagacttc 360
tccaacgagg aacggtttac tggctttgca gcgtattact cagccgtaga tgtaaatgaa 420
tgcacagact ttacagatgt cccttgcagc cacttctgca ataacttcat tggtggatac 480
ttctgctcct gccccccaga atacttcctc cacgatgaca tgaggacttg tggggtcaac 540
tgtagtgggg atgtattcac tgccttgatt ggggagatcg caagtcccaa ttatcccaac 600
ccatacccgg agaactcaag gtgtgaatac cagattcggc tgcaggaggg cttccgactg 660
gtgttgacta tccggagaga agattttgat gtggaaccag cggactcaga ggggaactgc 720
cacgacagtt tgacttttgc tgcaaaaaac caacagtttg gtccttactg tggcaatgga 780
ttccctggac ctctaactat taaaacccag agcaatactc ttgatattgt ctttcaaact 840
gacctaacgg ggcaaaataa aggctggaag cttcgttacc atggagatcc catcccctgt 900
cccaaagaaa tcagtgctaa ttctatctgg gagcccgaaa aggcaaaata cgtgttcaaa 960
gatgtcgtga agataacctg tgtggatgga ttcgaagttg tggagggaaa tgttggctca 1020
acatcattct attccacttg tcaaagcaac ggacagtgga gcaattccag gctagagtgt 1080
caacctgtgg actgtggtgt tccagaaccc attgagaatg gtaaagttga agacccagaa 1140
gacactgtat tcggctccgt catccactac acgtgcgaag agccatatta ctacatggaa 1200
caggaagaag gcggagagta tcactgtgct gctaatggga gctgggtgaa tgaccagctg 1260
ggtgtcgagc ttccaaaatg tattccagtc tgtggagtac ccaccgagcc ctttaaagta 1320
cagcagagga tatttggagg atactctaca aagattcaaa gttttccttg gcaggtctac 1380
tttgagtccc cccgaggtgg cggggctctt atcgatgagt actgggtgct gacggccgct 1440
cacgttgtgg agggaaactc tgacccagtg atgtatgtcg ggtccacact tctgaaaata 1500
gagcggttga gaaatgccca gaggctcatc actgaacgtg tgattattca tcccagctgg 1560
aaacaagagg acgacctgaa tacacggaca aattttgaca atgacattgc cctggtgcag 1620
ctcaaagacc ctgtgaaaat gggacccact gttgccccca tctgcctgcc agaaaccttc 1680
tcagactaca acccctcaga ggttgacctg gggctgatct ctgggtgggg ccgaacagag 1740
attagaacca atgttattca actcagaggg gcgaagttac ccataacatc tttagaaaag 1800
tgccagcagg tgaaagtgga aaacccgaaa gcgaggtcaa acgactatgt tttcactgac 1860
aacatgatct gtgctgggga aaagggtgtg gacagctgtg aaggtgacag cggaggggct 1920
tttgctctgc cggtccccaa tgtcaaggac cccaaattct atgtggctgg cctggtgtcc 1980
tgggggaaaa agtgtgggac ctatgggatc tacacaaagg taaagaacta cgtggactgg 2040
atcctgaaaa ctatgcagga gaatagtggg cccaagaagg actga 2085
<210> 6
<211> 807
<212> DNA
<213> Rattus norvegicus
<400> 6
atgagcgccg ctcttttcag cctagacagc ccagcacgcg gcgcaccctg gcccacagag 60
cccgcggcct tctacgagcc aggcagggtg ggcaagccag gacgagggcc ggagcctggg 120
gatctggggg agccgggctc cacgacccct gccatgtatg acgacgagag cgccatcgac 180
ttcagcgcct acattgattc catggctgcc gtgcccaccc tagagttgtg ccacgacgag 240
atcttcgccg acctcttcaa cagcaatcac aaagcggccg gcgcgggcag cctggagctg 300
ctgcagggcg gccctacgcg acccccgggt gtggggtcaa tcgccagggg cccgctgaag 360
cgcgaacccg actggggcga cggcgacgcg ccgggctccc tgctgccggc gcaagtggca 420
gtgtgcgcgc agacagtggt gagcttggcg gccgcggcac agcccacacc acccacttcg 480
cccgagcctc ctcgaggcag ccctggaccg agccttgcgc ctggccccgt ccgagagaag 540
ggcgccggca agaggggtcc ggaccggggc agccctgagt accggcagcg acgcgagcgc 600
aacaacatcg ctgtgcgcaa gagccgggac aaggccaagc gccgcaacca ggagatgcag 660
cagaagctgg tggagctgtc ggccgagaac gagaagctgc atcagcgtgt ggagcagctc 720
acccgggacc tggccagcct ccggcagttc ttcaaagagc tgcccagccc gcctttcctg 780
ccgcccaccg gcaccgactg ccggtaa 807
<210> 7
<211> 1482
<212> DNA
<213> Rattus norvegicus
<400> 7
atggctgact caaaaccact cagaaccctg gatggggacc ctgtggctgt ggaggctttg 60
ctccgggacg tgtttgggat tgtcgtagat gaggccattc ggaaggggac caatgcctct 120
gagaaggtct gcgaatggaa ggagcctgaa gagctcaagc agctgctgga cttggagctg 180
cagagccagg gcgagtctag ggagcggatc ctggagcgct gccgggctgt gattcattac 240
agtgtcaaga ctggtcaccc ccggttcttc aaccagctct tctcaggatt agatccccat 300
gctctggccg ggcgcatcat tacggagagc ctcaatacca gccagtacac atatgagatt 360
gcccccgtgt ttgtgctcat ggaagaggag gtgctgaaga aactccgtgc ccttgtgggc 420
tggaacactg gggatggggt cttctgtcct ggtggttcca tctctaacat gtacgccata 480
aacctggccc gctttcagcg ctacccagac tgcaagcaga ggggcctccg ggccctgcca 540
cccttggccc tcttcacttc aaaggagtgc cactactcca tcaccaaggg agctgctttt 600
ctgggacttg gcaccgacag tgtccgagtg gtcaaggctg atgagagagg gaagatgatc 660
cctgaggatc tggagaggca gatcagtctg gcagaggctg agggctcggt gccatttctg 720
gtcagtgcca cctctggtac caccgtgcta ggggcctttg accccctgga tgcaattgcc 780
gatgtttgcc agcgtcacgg gctgtggtta cacgtggatg ccgcctgggg tgggagcgtc 840
ctgctgtccc ggacacacag gcatctcctg gatgggatcc agagggctga ctccgtggcc 900
tggaaccctc acaagcttct cgccgcgggg ctgcagtgct ctgctcttct tctccgggac 960
acctcgaacc tgctcaagcg ctgccacggg tcccaggcca gctacctctt ccagcaagac 1020
aagttctaca acgtggctct ggacaccgga gacaaggtgg tgcagtgtgg ccgccgcgtg 1080
gactgtctga agctgtggct catgtggaag gcgcagggtg ggcaagggct ggagtggcgc 1140
atcgaccagg cctttgctct cactcggtac ttggtggagg agataaaaaa gcgggaagga 1200
tttgagttgg tcatggagcc cgagttcgtc aacgtgtgct tctggtttgt gcctcccagc 1260
ctgcggggga agaaggagag cccagattac agccagaggc tgtctcaggt ggcccctgtg 1320
ctcaaggagc gcatggtgaa gaagggaacc atgatgatcg gctaccagcc ccatgggacc 1380
cgggccaact tcttccgaat ggtggtggcc aaccccatac tggtccaggc cgatatagac 1440
ttccttctgg gcgagctgga gcgtctgggc caggacctgt ga 1482
<210> 8
<211> 627
<212> DNA
<213> Rattus norvegicus
<400> 8
atgaagctgc tgccgtcggt ggtgctgaag ctctttctgg ccgcagtgtt gtccgcgttg 60
gtgaccggtg agagtctgga gcggcttcgg agaggtctgg cggcagcaac cagcaaccct 120
gaccctccca ctggaaccac aaaccagctg ctacccacgg gagctgatcg cgctcaggag 180
gtccaggact tggaagggac cgatctggac cttttcaaag ttgctttctc ctccaagcca 240
caagccctgg ccaccccagg aaaagaaaag aacgggaaaa agaagaggaa aggcaagggg 300
ttaggaaaga agagagatcc atgccttaag aaatacaagg actactgcat ccacggagag 360
tgcagatacc tgaaggagct ccgtattccc tcgtgccact gcctccctgg ttaccatgga 420
cagaggtgtc atgggctgac cctaccggta gagaaccccc tgtacacata tgaccacact 480
accgtcttgg ctgtggtggc tgtagtactg tcatctgtct gtcttcttgt catcgtggga 540
cttctcatgt tcaggtacca taggcgagga ggttatgact tggaaagtga ggagaaagtg 600
aagttgggca tggctagctc ccactga 627
<210> 9
<211> 1767
<212> DNA
<213> Rattus norvegicus
<400> 9
atgtggatcc tggtgagctg gctggcctta gtggcaaggc tggtggctgg aacacagtgc 60
ccagatggtc aattctgccc tgttgcctgc tgccttgacc agggaggagc caactacagc 120
tgctgtaacc ctcttctgga cacatggcct ataataacga gccgtcgtct agatggctcc 180
tgccagatcc gtgaccactg tcctgatggc tactcttgtc ttctcactgt gtctgggact 240
tccagctgct gcccgttctc tgagggtgta tcttgtgatg atggccagca ctgctgcccc 300
cggggcttcc actgtagtgc ggatgggaaa tcctgctctc agatatcaga tagcctcttg 360
ggtgctgtcc agtgtcctgg tagccagttc gaatgtcctg actccgccac ctgctgtatt 420
atgattgatg gttcctgggg gtgctgcccc atgccccagg cctcttgctg tgaagacaga 480
gtgcattgct gtccccacgg ggcctcctgt gacctggttc acacgcgatg catttcaccc 540
acgggcaccc accccttact aaagaaattc cccgcacaaa ggaccaacag ggcagtggct 600
tccttttccg tggtgtgccc tgatgctaag acccagtgcc ctgatgactc tacctgctgt 660
gagctaccca ctgggaagta tggctgttgt ccaatgccca acgccatctg ctgttccgac 720
cacctgcact gctgccccca ggacactgta tgtgacctga tccagagcaa gtgcatatcc 780
aaggactaca ccacagatct catgaccaag ctgcctggat acccagtgaa tgaggtgaag 840
tgcgacttgg aggtgagctg tcctgatggc tacacctgct gccgcctcaa cactggggcc 900
tggggctgct gtccattcac caaggctgtg tgttgtgaag accacattca ctgctgccca 960
gccgggtttc agtgtcacac agagacagga acctgtgaac tgggagtcct tcaggtaccc 1020
tggatgaaaa aggtcacggc ctccctcagc ctgccagacc cacagatctt gaagaatgat 1080
gtcccctgtg atgacttcag tagctgtcct tctaacaata cctgctgcag actcagttct 1140
ggggactggg gctgctgtcc catgccagag gctgtctgct gcttagacca ccagcattgc 1200
tgccctcagg gtttcaaatg tatggatgag gggtactgtc agaagggaga cagaatggtg 1260
gctggcctgg agaagatgcc tgtccgccag acaactctgc tccaacatgg agatattggt 1320
tgtgaccagc ataccagctg cccagtaggg caaacatgct gcccaagcct gaagggaagt 1380
tgggcctgct gccagttgcc ccatgctgtg tgctgtgagg accggcagca ctgttgcccg 1440
gctgggtaca cctgcaacgt gaaggcgaga acctgtgaga aggatgcagg ctctgtccag 1500
ccttccatgg acctgacctt tggctctaag gttgggaatg tggaatgtgg tgccggacat 1560
ttctgccatg ataaccagtc ctgttgtaaa gacagccaag gaggctgggc ctgctgtccc 1620
tatgtaaagg gtgtctgctg tagagatgga cgtcactgtt gtcccattgg cttccactgt 1680
tcagccaagg gaaccaagtg tttgcggaag aagacccctc gctgggacat acttttgagg 1740
gatccagccc caagaccgct actgtga 1767
<210> 10
<211> 6447
<212> DNA
<213> Rattus norvegicus
<400> 10
atggacgcgc tcgagtcgtt gttggacgag gtggccctgg aggggctcga cggcctgtgc 60
ctgcccgcgc tgtggagccg cctggaatcc cgctcgcctg ccttcccttt gccgctggaa 120
ccctacacgc aggagtttct gtggcgggcc ttagtcacgc acccgggcat cagtttctac 180
gaggagccgc gagagcgacc tgacctgcag ctccaagacc gatatgaaga aatcgacttg 240
gaaactggaa ttttggagtc caggagggac ccagtcactc tggaagatgt ctaccccatt 300
catatgatct tagagaataa ggatggcatc cagggctcct gccgatactt taaggagaga 360
aaggacatca ccagtagcat caggagcaag tgtttgcagc ctcgttgtac aatggtagaa 420
gccttcagca ggtggggtaa gaagctcatc attgtggctt cccaggacat gcgataccgg 480
gccttgatag gcctagaggg ggatcctgat ctgaagcttc ctgatttctc ctactgcatt 540
ttggagcggt taggtcgatc gagatggcaa ggggagctgc aacgagacct tcacaccacc 600
gctttcaagg tcgacgctgg gaagcttcat tatcacagga aaattttgaa caagaatggg 660
ctcattacaa tgcagtcaca cgtgatccga ctgcctactg gagcccagca acactccatc 720
ctcctcctcc ttaaccggtt tcatgtagac aggaggagca agtacgacat cctcatggag 780
aagctgtcta tgatgctgag cacacggagc aaccagatcg agactctggg caagctgagg 840
gaggagctgg gactgtgtga aaggacgttc aagcgtctgt accagtacat gctgaatgct 900
gggctggcca aagtggtgtc ccttcccttg caggagattc accctgagtg tggtccctgt 960
aagaccaaga aagggactga tgtcatggtt cggtgcctta agctcctgaa ggagttcagg 1020
cgaaagatgg aagacgacca tgacgacgat gacgatgaag aggccatctc caaggctgta 1080
cctcccgtgg acatcgtgtt tgagcgggac atgctcacgc agacctacga gctcattgag 1140
cgcagaggaa cgaaaggaat ttcccaagct gagatccgag ttgctatgaa tgtgggaaaa 1200
ctggaagcaa gaatgctgtg tcggctcctt cagaggttca aggttgtcaa gggattcatg 1260
gaagatgaag gccggcagag gaccaccaag tacatttcct gtgtatttgc ggaggagagt 1320
gacttgagcc gccaatatgc gcgtgaaaag gcccgaggag agctgctaac cactgtgagc 1380
ctcgcctcag tgcaagatga atccctcatg cctgagggtg aagaggcctt cctctctgac 1440
tccgaaagtg aggaagagag cagctgcagt ggcaagcgta ggggccgagg gtcccggggg 1500
cattcaagag cctctgggga tgctgggcct ggctctcggc ctcatcactc cactccagcc 1560
aagggcgggt ggaaagtcct aaatctgcac ccattaaaga agcccaaaag tgccgctgtg 1620
gaaagatccc gccgaagctc tgcttgtagg gatggcctgg acaccagcag ctcatccgag 1680
ctcaatatac cctttgaccc tcacagcatg gacagtcaca gtggtgacat cgctgtgatt 1740
gaggaggtcc ggcttgataa ccccaaggag ggtggtggct cccagaaggg cggacggcat 1800
ggctcaggcc aggacaagcc tcacaaaaca taccgactgc taaagcgcag aaatctgatt 1860
atagaagctg tcaccaacct ccgcctgatt gagagcctgt tcacgattca gaagatgatc 1920
atggaccagg agaagcaaga gggtgtctcc accaaatgct gtaagaagtc cattatccgc 1980
ttggtgcgga acctgtctga ggagggtctc ttgagattgt ataggactac agtcattcaa 2040
gatggcatca agaagaaggt agacctggtc gtgcaccctt ccatggacca gaatgaccct 2100
cttgtgagaa gtgctattga gcaggttcgc ttccggatct ccaactcaag cacagcaaac 2160
agggttaaag ttccaccggc cccagcaccc caagaggaag cagaagaggg aaaccaagaa 2220
ccagaggtcc caagtagatc agcagactct gaagcgaaca catcctcgaa gccagaaagc 2280
acacgggtga aaaagacaga tgagaaaatg ggcataaccc cactcaagaa ttacaaacct 2340
gtcatagttc ctggacttgg gcgctccata gggttccttc ccaagatgcc acgccttcgg 2400
gtgatgcacc tgttcctgtg gtacctggtg tatgggcatc ctgccagcca cactggggaa 2460
cagcctactt tccacagtga gaggaaaaca ggcaagcagg agcccagcag accaggggtc 2520
cagccctcct caggagatga ctgggactcc tctgaagcca aaaacagcac agaaagcagc 2580
tcctgggagg cagaaatgga actctccaca gagagagtgt atgtggatga gatctcatgg 2640
atgcgctacg tccctcccat ccccatccac agagacttcg gctttggctg ggctcttgtc 2700
agtgacattc ttctctgcct tcccctctcc atctttgtcc aagttgttca agtcagctac 2760
aaggtggata acctggagga ttttctgaat gaccctctga agaagcacac actgatccgc 2820
ttcctcccta ggcacatccg gcagcagcta ctgtataaga ggcggtatat tttctcggtg 2880
gtggagaacc tgcaacggct gtgctacatg gggctgctac agtttggacc cacagagaag 2940
tttcaggata aagaccaggt ctttgttttc ctgaagaaga atgcagtcat tgtggacacc 3000
accatctgtg acccacatta caacctggcc cacagcagcc ggccttttga gagacgtctc 3060
tacgtcttgg attccatgca ggatgtggaa agctactggt ttgacctgca gtgtatctgc 3120
ctaaacaccc cactaggtgt ggtgcgttgt ccatgtgcac agaagatctg ccctgatccg 3180
ggcagtgacc cagaaggcag cttgcggaag gagcaagaga gcgccatgga caagcacaac 3240
ctagagcgca agtgtgccat gctggagtat accacgggga gccgagaagt tgtggatgaa 3300
ggcttagtcc ctggggatgg actgggagct gctgggctgg actctagctt ctatgcacac 3360
ctgaagcgca actgggtctg gaccagctat atcatcaaca aagccagaaa gaacaacacc 3420
tccgaaaatg ggctcacagg aagactccag actttcctgt ctaagcgccc aatgccactt 3480
gggtctggag gcagtggccg tctgcctctc tggtcagagg ggaaagctga tgctgagctc 3540
tgtgctgaca aagaggaaca ctttgaactg gaccgagaac ctacccctgg caggaaccga 3600
aaagtgcgtg ggggcaagag tcagaagcgg aagcggctga agaaggagcc catcaggaag 3660
accaagcgaa ggagaagagg agagcatcca gaagccaaaa gcaaaaaact acgctaccaa 3720
gatgaggctg accagaacgc cctccggatg atgacccggc ttcgggtttc ttggtccatg 3780
caggaggatg ggttactaat gctctgccga attgccagca atgtcctcaa caccaaggtg 3840
aaaggaccat ttgtcacctg gcaggtcgtg cgtgacattt tgcatgctac ctttgaagag 3900
tctttggata aaacatctca ctcggttgga cgaagagctc gctacatagt caaaaatccc 3960
caggccttta tgaactacaa agtctgcctg gcagaagtgt accaagataa ggcactcgtt 4020
ggagatttca tgagtcggaa ggataactac gaagacccaa aggtctgtgc caaggagttt 4080
aaagaatttg tggagaagct gaaagagaag ttcagctctg gcctgaggaa ccccaacctt 4140
gagatcccag acacactgca ggaactcttt gccaaatacc gggtgttggc aatcggagat 4200
gaaaaggacc gtgtcaggaa ggaggatgaa ctgaatagtg tggaggacat ccacttcctg 4260
gtgctacaga acctgatcca gagcacactg tccctctcta acagccagtc caactcttgc 4320
cagtccttcc agatcttccg cctctaccgg gagttccggg agcctgtgct ggtgcgggcc 4380
ttcatggagt gccaaaagag gagcctggtc aaccgacgcc gtgtcagcca ctcccagggt 4440
cccaagaaga accgtgctgt gccctttgtg cccatgtcct accagctctc ccagtcatac 4500
tacaagcttt tcacctggcg atttcccacc accgtctgca ccgaatcctt ccagttctat 4560
gacagactac gggccaacgg catactagac cagcctgatc atttttcttt caaggacatg 4620
gatagcaatg acccttcaag tgacctggtg gcgttttctt tggacagccc tggaggacac 4680
tgtgtgacag ccctggccct cttctccttg ggcctcctct ctgtggatgt ccgaatccca 4740
gagcagattg tggtggtaga cagctccatg gtggagagtg aggtcatgaa gagcttgggg 4800
aaagatggcg gcttggatga tgatgatgag gaggaagacc tggatgaagg ttcagggacc 4860
aagcgtcaga gtgtggaagt aaaggcccat caggcctcac acaccaagta cctgctgatg 4920
agaggttact acacagtgcc tggcatggtc agcacgcgca acctgaaccc caatgacagc 4980
attgtggtca attcctgcca ggttaaattc cgactgcgca atacccctgc acccacccat 5040
cttgggccca ctgggcccac agccacaccg ctagaagagc tccaggctgg cccttcctgc 5100
ctccctgcct cctttaccag cctggtggat ccacagctgc acacccgctg cccagaagag 5160
tttgcccacc agatggcaca gtctgggtac agccctgagg acgtggctgc gtccctagag 5220
atcctgcagg ctgtggcagc tgctgactgc ttcggggttg acagggagaa gctgagcaga 5280
cagttctctg ccttggagaa gatagcggac aagcgcacca ggacgttcct ggactatatc 5340
caggacctct tggaacagca acaagtcatg gaagttggag gcaacactgt gcgcctagtg 5400
gccatggcct ctgcccagcc ctggctcctg ccttcagtgc gtctgaaaga tgtggaaata 5460
gacaccaagg cctcagggga tgacagccaa tctagactcc ctgcggggtc ttccatcgaa 5520
gaccacacct ctgagggtgc accaattcct ccagtcagct ccaatggcac taaaaagcgc 5580
ccctactgct ctattcagag ccctgaaact gatgctgagg aagctacaag gctccctgcc 5640
aagaagccca cattacaaga tgtctgtgtg gctgccagtc ctaggcctgg aacagaagag 5700
cagacagagg cccaggctca gtttgcagct cctgaagatg caggtgcaga gggccccagg 5760
caggagagcc aagagagtgt tggtgtctca ggcctagagc agctgggctg tgagttccag 5820
cttccagaaa attctgaaga ccccagagga cttacagaga gcaacatggc ccaggtagca 5880
tgggagagcg gctgtgaaag agtatgtttt gtcggtcgcc catggcgtgg tgtggacggg 5940
cgcctgaaca tgcccgtgtg caaaggcatg atggaagccg tgctgtacca catcatgtca 6000
aggcccggtg ttcctgagag ctgcctgcta cagtactacc agggcgtcct acagcctgtt 6060
gctgtgcttg agctgctccg gggcttagag tctctcggct gtatccagaa gcggatgctg 6120
aagaagccag cgagtgtctc actcttctcc aggcctgtgg tggagggcct aggtcaggcc 6180
agtgaggccg aggcactctc ctgtcagggg agcactgtca ccttttatga acctactctg 6240
gactgtacca tccgtctggg ccgtgtcttc ccccatgaca tcaactggaa acaaagtgga 6300
tccatttata gatgcgtccc aggccagcag aggagcctct gcccgtgctt aattgttccg 6360
cctggactgt cccaagagcc ccgtccttca cacagctgtt accagagctc ggcccagcct 6420
agcacaggtg tagcaactag caggtga 6447
<210> 11
<211> 1146
<212> DNA
<213> Rattus norvegicus
<400> 11
atgaacccgt tttcctctga gtcagcatgg ctctgcttga ctgccactgc ggtgctgggg 60
ggcatgcttc tctgcaaagc ctggagttca gggcagctaa ggagccaggt ggtgtgtctg 120
gctggcctct ggggaggtgc ctgcctgctc agcctgtccc tcctctgcag cttgttcctc 180
ttatcggtgt cctgcttctt ccttctgtat gtgagttcat ctgaccaaga cttgttacct 240
gtggatcaaa aggctgtgct ggtgacaggt gccgattccg gtttcggtca tgctttggcc 300
aagcacctgg acaagctggg tttcacagtg tttgctggag tgctggataa agagggccca 360
ggagcggagg aattgaggaa aaactgctct gagcgccttt cggtgctcca gatggatgtc 420
accaagccag agcagataaa agatgttcac agcgaagtcg cagagaagat acaagacaaa 480
ggactgtggg ctgtggtcaa caatgctggg gtcttgcact ttccgatcga cggggaactc 540
attcccatga ccgtgtacag aaaatgcatg gcagtgaact tcttcggagc cgtcgaggtc 600
accaaggtgt ttctgcctct acttagaaag tccaagggga ggctggttaa cgtcagcagc 660
atgggagcca tgattccatt tcagatggtg gccgcctacg cctccacgaa ggcagctata 720
agcatgttct cagccgtcat caggcaagag cttgccaaat ggggagtcaa agtcgtgacc 780
atccatcctg gaggcttcca aacaaacatc gtaggctcac aggacagttg ggataaaatg 840
gagaaggaga tcctggacca cttttccaaa gagattcagg agaactatgg acaggaatat 900
gtccatacgc agaagctcgc cctcccggtc atgagagaga tgtccaaccc ggatatcacc 960
cctgtgctgc gggacatcca gcacgccatt tgtgccaaga acccctcttc cttttattgc 1020
tcagggagaa tgacttacct gtggatctgc ttcgcggcct actccccgat cagcttattg 1080
gactatattt tgaaaaacta ttttactcca aaactcatgc caagagcttt aaggacagca 1140
agttag 1146
<210> 12
<211> 1011
<212> DNA
<213> Rattus norvegicus
<400> 12
atgattggca aatggagaat ggggctttgg gctttggcaa ttctgacagt tcccatgtat 60
ttcatagtga cagagggcag aaaaacatcc tggggtctag aaaacgaggc tttaattgtc 120
agatgccccc aaagaggagg tgcgattaac cctgtggaat ggtattattc aaatacaaat 180
gaaagaattc ctactcaaaa gagaaatcgg atcttcgtct caagagatcg tctgaagttt 240
ctaccagcca aagtggaaga ctctgggatt tatacgtgtg ttatcagaag ccctgaatcg 300
attaagaccg gatctttgaa tgtcaccata tataaaagac caccaaactg caaaatccct 360
gattacatga tgtactcgac agtagatgga tcagataaaa attccaagat aacatgtcca 420
acaattgcct tgtataattg gacagcgcct gttcagtggt ttaagaactg caaagctctc 480
caagggccaa ggttcagggc acacatgtcc tatttgttca ttgacaaagt gagtcatgtt 540
gatgaaggtg actacacatg tcgattcact cacacggaga acggaaccaa ttacattgtg 600
actgccacca gatcattcac agttgaagaa aaaggcttct ctacatttcc agtaattaca 660
aaccctccac acaactacac agtggaagtg gaaataggaa aaacagcaaa cattgcctgc 720
tcagcttgct ttggcacagc ctctcagttc gttgctgtcc tgtggcagat taacaaaacg 780
agaattggat cttttggcaa agcaagaatt caagaagaga aaggcccaaa taaaagttcc 840
agcaatggca tgatttgctt aacctcactg ttaaggataa ctggtgtgac cgacaaggac 900
ttctccctga aatatgactg tgtggccatg aaccatcacg gagtgataag gcaccccgta 960
agactgagaa ggaaacaacc aagtaaggag tgtctctcac aaattgcttg a 1011
<210> 13
<211> 5289
<212> DNA
<213> Rattus norvegicus
<400> 13
atgtcagttc ttatatcaca gagtgtgata aattatgtgg aagaagagaa tattcctgct 60
ctgaaagctc ttcttgagaa gtgcaaagat gtagatgaga ggaacgagtg tggccagacg 120
ccgctgatgc tggctgcgga gcagggcaat gtggaaatag tgaaagaact gttaaagaat 180
ggagccaact gcaatctgga agatctggat aactggactg cccttatatc ggcatctaag 240
gaggggcaca tccacattgt ggaggagctg ctgaagagcg gggccagtct ggagcaccga 300
gacatgggtg gatggacagc tctcatgtgg gcgtgctaca aaggcaggac cgacgtggtc 360
gagctgcttc tttctcatgg tgccaaccca agtgtcactg gtttgtatag tgtctaccca 420
atcatctggg cagcgggcag aggccatgcc gacatagtgc atcttctact gcagaatggt 480
gcgaaagtca attgctccga caagtacgga acaaccccct tggtatgggc tgcccgaaag 540
ggtcatttgg aatgtgtgaa gcacttgttg gccatgggag ctgatgttga tcaagaagga 600
gccaattcga tgactgcact tatcgtggca gtgaaaggag gctacacaca gtccgtgaaa 660
gagattttga aaaggaatcc aaatgtgaac ctaactgaca aggatggaaa cacagctctg 720
atgatcgcat cgaaggaggg acatattgag attgtgcagg acctgctgga cgccggaaca 780
tacgtgaaca tacctgacag gagtggggat actgtattga tcggcgctgt gagaggtggt 840
catgttgaaa ttgttcgagc acttctccaa aaatatgctg atatagacat tagagggcag 900
gacaataaga ccgcgctgta ttgggccgtt gaaaagggaa atgcgacaat ggtgagggat 960
atcctgcagt gcaatccgga cacggaaata tgcacgaagg atggtgagac accactgata 1020
aaagccacca agatgagaaa tattgaagtg gtggagctgc tgctggataa gggggctaag 1080
gtgtctgctg tggacaagaa aggggacact cccctgcacg ttgccatccg agggaggagc 1140
cggagactgg ccgaacttct tttacggaac cccaaagatg gacggttact ctacagaccc 1200
aacaaagcag gcgagactcc ctacaacatt gactgcagcc accagaaaag cattttaact 1260
caaatatttg gagccagaca cttgtctcct acggaaacag atggcgacat gcttggttat 1320
gatttgtata gcagtgccct ggccgatatt ctcagtgaac ccaccatgca accacccatt 1380
tgtgtgggct tgtatgcaca gtggggaagt gggaagtctt tcttactcaa gaaactagaa 1440
gatgagatga agacgtttgc aggacagcag accgagcccc tcttccagtt ctcgtggctc 1500
atagtgttcc tcaccctgct gctgtgtggc gggctcggcc tagtgtttgc tttcacggtt 1560
gatacaaacc tcgccatagc catttcattg agtttcctgg ctctcatata tatattcttc 1620
atcgtcattt acttcggtgg acggcgggaa ggagagagtt ggaactgggc ctgggctctc 1680
agtaccagac tggcaagaca cattgggtac ctggagctcc tcttcaaact gatgtttgtg 1740
aacccacctg aactgccgga gcaaactaca aaggctttac ctgtgaggtt tttgtttaca 1800
gattacaata gactctccag tgtgggagga gaaacttcct tggctgaaat gatcgcgacc 1860
ctctcagatg cttgtgagag agaattcggc tttttggcta cccgtctttt tcgagtcttc 1920
aggactgaag agtctcaggg taaaaagaaa tggaaaaaaa catgctgcct cccctctttt 1980
gtcatctttc tttttattgt tggctgcatt attgctggga tcacccttct ggctatattc 2040
agagttgacc cgaaacatct gacagtgaat gctatcctca tttctatcgc atctgtcgtg 2100
gggttggcct tcgtgctcaa ttgtcgaaca tggtggcaag tgctggactc tctcctgaat 2160
tctcagagaa aacgcctcca tagtgctgcc tccaaattac acaagttaaa aagtgaagga 2220
ttcatgaaag tcctgaagtg tgaggtggag ctgatggcca ggatggcaaa aaccattgac 2280
agcttcactc aaaaccagac aaggctggtg gttatcattg acggcctgga tgcctgcgag 2340
caggataaag tccttcagat gctggacact gtccgagttc tgttttcaaa gggccctttt 2400
attgccattt ttgcaagtga tccgcatatt atcataaagg ccatcaacca gaacctgaat 2460
agtgtgcttc gtgactcaaa tataaacgga catgactaca tgcgcaatat agttcactta 2520
ccagtttttc ttaatagtcg tgggcttagc aatgcaagga aattccttgt aacttcagca 2580
acaaatgggg acattacatg ctcagacacc acaggaacac aggaggacac tgacagaaga 2640
gtttcacaga acagccttgg ggagatgaca aagcttggga gcaaaacggc tctcaacaga 2700
agggacactt accgcagaag acagatgcag agaaccatca cgaggcagat gtcctttgat 2760
ctcacaaagc tgctggtcac tgaggattgg ttcagtgaca tcagccctca gaccatgaga 2820
cggctactca atattgtttc tgtgacaggg cggctactaa gagccaatca gattactttc 2880
aactgggaca ggctagccag ctggatcaac ctcaccgagc agtggccgta ccggacgtct 2940
tggcttatac tatatctgga agagactgaa ggtctccctg atcagatgac cttaaagacc 3000
atctatgaga gaatatcgaa gaatatccca acaactaaag atgttgagcc gcttcttgaa 3060
attgatggag atataagaaa ctttgaagtc ttcttgtctt caaggactcc agttctcgtg 3120
gctcgagatg taaagacctt tttgccgtgc acagtaaacc tggatcccaa acttcgggag 3180
atcatcgcag atgtccgagc tgcaagagag cagatcaaca taggaggcct ggcctatccc 3240
ccgctccctc tgcacgaagg ccctcctcgg ccaccttctg ggtacagtca gcctgcatct 3300
gtctgctctt cagcatcttt caacgggccg ttcccaggcg gggttgtgtc tccacagccc 3360
cacagcagtt actacagcgg cttgtccgga ccccagcacc ccttctacaa caggccattc 3420
tttgccccat acctttacac gccaaggtat taccctggcg gttcccaaca tctcatctca 3480
cgttcatcag taaaaacgag tttgcccaga gatcagaaca atggcctacc gtgtgactct 3540
gggtttaaca aacagagaca ggcagccgtc cctgccacag gcagctcact gttactgagt 3600
tcaatgaccg tggatgtcgt atgtgagaaa ctgagacaga tagaagggct ggaccagagc 3660
atgatgcctc agtactgcac aacaatcaaa aaggcgaaca taaatggccg ggtattgtct 3720
cagtgtaaca ttgatgagct gaagaaagag atggctatga actttggaga ctggcatctc 3780
ttcagaagca tggtcttaga aatgagaagt gtggaaagcc aggtggtccc tgaagaccct 3840
cgttttctca atgaaaactc cagtgcccca gttcctcatg gagagtctgc tcgccgctct 3900
tctcacactg agctgcccct cacggagctt tccagccaga ctccatacac cctgaacttc 3960
agctttgaag aactgaacac gcttggcctt gatgagggag cccctaggca cagtaacctg 4020
agttggcagt cacaaactcg cagaacccca agtctctcga gtctcaattc ccaggactcc 4080
agtattgaaa tttcaaagct tactgataag gtgcaggccg agtatagaga cgcctataga 4140
gagtacattg ctcagatgtc ccagttagaa gggggcacag ggtcgtccac aataagcggc 4200
agatcttctc cacatagcac atactacata ggccagagct cttcaggggg ctccatccat 4260
tctactctag aacaggaaag ggggaaggag ggtgagctaa agcaggagga tgggcggaag 4320
tcatttttaa tgaagagggg ggatgtcata gattactcct catcaggggt gtccactaat 4380
gaggcctcac ccctggaccc cattactgaa gaagatgaga aatccgacca gtcaggtagt 4440
aagctactcc caggcaagaa atcctcagaa cggcccagtc tcttccagac agacttgaag 4500
cttaaggggg gtggtcttcg ctaccagaaa ctgcccagtg atgaagatga gtcggggaca 4560
gaagagtcag ataacacccc actgctcaaa gatgataagg acaaaaaggc tgaaggcaaa 4620
gcagagagag tgtgcaagtc cccagagcac agtgccgagc ccatcagaac gttcattaaa 4680
gcaaaagagt atttgtccga tgccctcctt gacaaaaagg attcctcaga ttcgggagtg 4740
aggtccaatg agagttctcc caaccactct ctccacaatg aggcagcaga cgactcccaa 4800
ctggaaaagg caaacctcat agagcttgaa gatgagggcc acagtgggaa gcgggggatg 4860
ccacacagtc tgagtggctt gcaagatcca attatagctc ggatgtccat ttgctcggaa 4920
gacaagaaaa gcccttccga gtgcagcctg attgctagca gccctgaaga aagctggcct 4980
gcgtgccaga aggcctacaa tctaaaccga acgcccagca ctgtgactct gaacaacaac 5040
actgcaccca ccaacagagc caatcagaac ttcgatgaga tagagggaat cagggagacg 5100
tcccaggtca ttctgaggcc tggccccagt cccaacccaa ctgctgtgca gaatgaaaac 5160
ctgaagagca tggcgcacaa gcgaagccag cgctccagtt acacaaggct ctcgaaagat 5220
gcatctgagc tacatgcagc ctcctcggag agcacaggct ttggagaaga gagagagagc 5280
attctctga 5289
<210> 14
<211> 1572
<212> DNA
<213> Rattus norvegicus
<400> 14
atggtggatg aaacaggctt cccccaggca aggacacagg gaactgtccc accttctgtc 60
ctgttagctt gctctgcacg tcaccctcac ggcctattgc gccaggaaga accttgctgg 120
ctctccacag ccctggggac ccgcctggct ttgctatccc actgggacac tcaaggtcag 180
ccaagcagga ctctggccaa cagtggcagt ttgggctaca atccagcaaa gctctgtgtg 240
ctggcaaagc acagccaggc actgtggaaa ggaaaaactc acctggccta cggggtaggc 300
atagtgccag ctcaggctaa acgagaccag aaggtgcact acccaggtgc ccctcttaca 360
tccagcgcca gcccagctga acccagccgc ccaaagcacg cctacagatc ccacagaagc 420
tgtaccagga tgtgtgacga cgaggagacc acagctttgg tgtgcgacaa tggctccgga 480
ctggtgaagg ctggctttgc gggtgatgat gctcccagag ctgtcttccc atccatcgtg 540
ggtcgcccac gccaccaggg tgtcatggta ggtatggggc agaaagactc ctatgtaggt 600
gacgaggctc agagcaagcg aggcatcctg actctgaagt accccataga gcacggcatt 660
atcaccaact gggacgacat ggagaagatc tggcaccaca ccttctacaa tgagctccgt 720
gtggcccctg aggagcaccc gaccctgctc actgaggccc cactgaaccc caaggccaac 780
cgtgagaaga tgacacagat catgtttgag accttcaatg tgcctgccat gtatgtggcc 840
atccaggcgg tgctgtccct gtacgcttct gggagaacca caggcattgt tctggattct 900
ggcgacggtg tgactcataa cgtccccatc tatgagggtt atgccttacc ccatgccatc 960
atgcgtctgg atctagctgg tcgggacctc actgactacc ttatgaagat cctcactgag 1020
cgcggcttga ctatgaagcc ctctgtctct gcagctgaac gtgaaattgt ccgagacatc 1080
aaagaaaaac tgtgttatgt cgccctggat tttgagaatg agatggccac cgctgcatct 1140
tcctcctctc tggagaagag ctacgaactt cccgatggcc aggtcatcac cattggcaac 1200
gagcgtttcc gctgtcctga gactctcttc cagccctctt tcattggtat ggagtctgcc 1260
ggcattcacg aaactactta taacagcatc atgaagtgtg acatcgatat ccgcaaagac 1320
ctgtacgcca acaatgtcct gtctggaggc accaccatgt accctgggat tgctgatcgt 1380
atgcaaaagg aaataactgc actggctccc agcaccatga agattaagat tattgctccc 1440
cctgagcgta aatactctgt ctggattggg ggctccatcc tggcctctct gtctaccttc 1500
caacaaatgt ggatcagcaa gcaagagtac gatgaggccg ggccctccat tgtccaccgc 1560
aagtgcttct ga 1572
<210> 15
<211> 3123
<212> DNA
<213> Rattus norvegicus
<400> 15
atggcggcag cgccgttctt gaagcactgg cgcaccactt ttgagcgggt ggagaagttc 60
gtgtccccga tctacttcac cgactgtaac cttcgcggca ggctcttcgg ggacagctgc 120
ccggtgacac tctccagctt cctgacgccg gaaaggcttc cctatgagaa ggcagtgcag 180
cagaacttca gccctgcgca ggtcggcgac agcttcggac ccacatggtg gacctgctgg 240
tttcgggtag aactggtcat ccctgaagtt tgggtgggca aggaagttca tctttgctgg 300
gaaagtgatg gagaaagcct tgtctggcgt gatggggaac ctgtccaggg tttgaccaag 360
gagggtgaaa agactagtta tgtcctgagt gagaggctgc acgcagcaga tcctcggagc 420
ttgactctct atgtggaagt agcctgcaat gggcttctgg gagccgggaa gggaagcatg 480
atcgcagccc ctgaccctga gaagatgttc cagctgagcc aggctaagct ggctgtgttc 540
caccgggatg tccacaatct cctggtggac ctggagctgt tgctgggtgt ggccaagggc 600
ctcggggagg acaaccagcg cagcttccag gccctgtaca cagccaacca gatggtgaac 660
atatgtgacc ctgcgcagcc tgagacttac ccagcagccg aggccctggc ctccaagttc 720
tttggccaac gtggaggtga aagccagcat accatccatg caacaggaca ctgtcacatt 780
gatacagcct ggctttggcc cttcaaggag actgtgagga aatgtgcccg gagctggtca 840
acagctgtga agctcatgga gcggaacact gagttcacct ttgcctgctc tcaggcacaa 900
cagctcgagt gggtaaagaa ccaataccct ggtctgtatg cccagctcca ggagtttgcc 960
tgccgaggac agtttgtgcc tgtggggggc acctgggtag aaatggatgg gaaccttccc 1020
agtggagagg ccatggtgag gcagttccta cagggccaga acttctttct gcaagagttt 1080
ggaaagatgt gctctgagtt ctggctgcca gatacatttg gctactcagc acagctcccc 1140
cagatcatgc aaggctgtgg catcaaacgc ttcctgacac agaaactgag ctggaacttg 1200
gtcaactcct tcccacacca taccttcttc tgggaggggc tggatggctc ccaagtgctg 1260
gtacacttcc cccctggaga ctcatatgga atgcagggca gtgtggaaga ggtgctgaag 1320
actgtgacca acaaccggga caagggacgg accaaccaca gtggcttcct ctttggcttc 1380
ggggatgggg gtggtggccc cacacagacc atgttggacc gattgaagcg gctgggcaac 1440
actgatgggc agcccagggt gcagctgtct tctcctggac agctcttcac agcactggag 1500
agagactcag ggcagctgtg cacatgggtt ggggaactct tcttggagct gcacaatggc 1560
acctatacta cccatgccca gctcaagaag gggaaccgag aatgtgagca gattcttcat 1620
gacgtggagc tgctcagcag ccttgcccta gcccgaagtg cccagttcct gtacccggca 1680
gtccagctgc agcgcctctg gaggctccta ctcctcaacc agttccatga tgtggtgact 1740
ggaagctgca ttcagctggt ggcagaagat gccatgaact actatgaaga catccgttct 1800
catggcaata cgctgctcag tgctgcagcc gcagccttgt gtgctgggga gccaggtccc 1860
aagggcctcc gtcattatca acacactgcc ctggaagcgc acagaagtgt tggcactacc 1920
caaggccttg tggggctcac acgcctagcc ctggtgacag tgcccagtat tggctatgct 1980
cctgctccca cccctacttc actgcagccc ctcctacccc agcagcccgt gtttgtgatg 2040
caggagactg acggttccgt gacgctggac aatggcatca tccgggtgag actggatcca 2100
actggctgtc ttacttccct ggtcctggtg gcttctggca gggaagccat tgctgagggt 2160
gccctgggga atcagtttgt gctgtttgat gatgtgccac tgtactggga tgcatgggac 2220
gtcatggact accatctaga gacacggaag cctgtgcggg gccaggcagg taccctggca 2280
gtaggcgctg aaggtggcct tcggggtagt gcctggttcc tgctacagat cagccccaac 2340
agtcggctca gccaggaagt cgtgctggat gttggttgcc cctatgtccg cttccacacg 2400
gaggtgcact ggcacgagac ccacaagttc ctgaaggtgg agttcccagc tcgagtacgg 2460
agcccccagg ctacctatga gatccagttt gggcaccttc aggaggccga cccacaacaa 2520
cactcctggg actgggctcg ctatgaggtg tgggctcatc gctggataga tctgtccgag 2580
tgtgactttg ggctggccct gctcaacaac tgcaagtatg gaacgtcagt acgaggcaac 2640
gtcctcagcc tctcactgct gcgtgcaccc aaggctccag atgttactgc tgacatgggg 2700
cgccatgaat tcacttatgc cttgatgcca cacaagggtt ctttccaaga agctggtgtt 2760
atccaggctg cctacaacct caactttccc ctcttggcac tgccagctcc aggcccagcc 2820
cctgatacca cctggagcgc cttttccgtg tcttcaccag cagtcgtgtt ggagaccatc 2880
aagcaggccg agaagagcca tcagcaccgc acactggttc taaggctgta tgaggctcat 2940
ggcagccatg tggactgctg gctacacaca tcattgcctg ttcaggaggc caccctttgt 3000
gacctcctgg agcagcgaga ccctaccggt cacctgtccc ttcaggacaa ccgcctgaag 3060
ctcacctttt ctccctttca agtgaggtcc ttattgcttg tgcttcagcc tccagcaaac 3120
tga 3123
<210> 16
<211> 1104
<212> DNA
<213> Rattus norvegicus
<400> 16
atgagctccc cgccacccgc ccgcaagggc ttttaccgcc aggaggtgac caaaacggcc 60
tgggaggtgc gcgccgtgta ccaggacctg cagcccgttg gctctggtgc ctatggtgca 120
gtgtgctctg cagtagacag ccgcactggc aacaaggtgg ccatcaagaa gttgtaccgg 180
cccttccagt cggagctgtt tgccaagcgc gcctacagag agttgcgcct cctcaaacac 240
atgcgccacg agaacgtcat tgggctgctg gatgtgttca ctcccgatga gactctggat 300
gacttcacag acttctacct ggtgatgcca ttcatgggca ctgacctggg caagctcatg 360
aagcacgaga ctctgagtga agacagaatc cagtttcttg tgtatcagat gctgaagggg 420
ctgaagtata tccacgctgc cggcgtcatc cacagggact tgaaacctgg aaacctggct 480
gtgaacgagg actgtgagct gaagatccta gattttggcc ttgccaggca ggcggacagt 540
gagatgacag gatatgtggt aacccggtgg tatcgggcac cagaggtcat cttgaattgg 600
atgcgttaca cacagacagt ggacatttgg tctgttggct gcatcatggc agagatgatt 660
actggaaaga tcctgttcaa aggcaatgac cacctggacc agctgaagga gatcatgaaa 720
gtcacaggga caccccctcc tgagtttgta cagaagctac agagtgctga ggccaagaac 780
tacatggaag gcctccctga gttggaaaag aaggattttg cttctgtcct gaccaatgca 840
agccctcagg ccgtgaatct cctggaaaag atgctggtgt tggatgcgga acagcgggtg 900
acagcagctg aggcattagc ccacccatac tttgagtccc ttcgggacac tgaggatgag 960
cccaaggccc agaaatatga tgactccttt gatgacgtag accgcaccct tgaggaatgg 1020
aagcgtgtta cgtataagga agtgctcagc ttcaagcctc ccaggcagct aggagccaga 1080
gttccaaagg agacagctct gtga 1104
<210> 17
<211> 2190
<212> DNA
<213> Rattus norvegicus
<400> 17
atgtcgtgtt gtgacctggc tgcggcggga cagttgggca aggcgggcat catggcctcg 60
gattgtgagc cagctctgaa ccaggcagag agccgaaacc ccaccctgga gcgctacctg 120
ggagccctcc gtgaggccaa gaatgacagc gagcagtttg cagccctgct gctagtaacc 180
aaggcagtca aagcaggtga cattgacgcc aaaactcgac gtaggatctt tgatgctgtt 240
gggttcacct ttcccaaccg actcctgact actaaggagg cccctgatgg ctgccctgac 300
cacgttctcc gggccctggg cgtggccctg ctggcctgtt tctgcagcga ccctgaacta 360
gccagccatc cccaggtcct gaacaagatc cccatccttt gcacattcct gacagcccga 420
ggggatcctg atgatgctgc ccgccgctcc atgattgatg acacctacca gtgcctgaca 480
gctgttgcag gcacaccccg agggccccga cacctcattg ctggtggcac agtgtctgcc 540
ctgtgccagg catacctggg gcatggctat ggctttgacc aggccctggc actcctggtg 600
gggctgctgg ctgctgcaga gacacagtgc tggaaggagg cagagcccga cctgctggct 660
gtgttgcgag gcctcagcga ggatttccaa agagctgaag atgccagcaa gtttgagctc 720
tgccagctgc tgcccctttt cctgccccca acaactgtgc cccctgaatg ccaccgggat 780
ctgcaggctg ggctggcacg catcctagga agcaagttga gctcctggca gcgcaatcct 840
gcactgaagc tggcagcccg cctggctcat gcctgcggct ccgactggat cccagtgggc 900
agctctggga gcaagtttct ggccctcctg gtgaatctgg cctgcgtgga ggtgcgactg 960
gctctcgagg agacaggcac agaggtgaaa gaagacgtgg taactgcctg ctatgccctt 1020
atggagttgg ggatccagga gtgtacccgc tgtgagcagt ccctgctgaa ggagccccag 1080
aaagttcagc tcgtgagcat catgaaagag gccatcggag ctgtcattca ctacctgctg 1140
caggtggggc cagagaagca gaaagagccc tttgtgtttg cctctgtacg gatcctgggt 1200
gcctggctgg cggaggagac ctcatccctg cgtaaggagg tgtgccaact gctgcccttc 1260
cttgtccgat atgccaagac actctatgag gaggctgagg aggccagtga catttcgcag 1320
caggtggcta acttggccat ctctcccact acaccagggc ctgcttggcc aggggatgct 1380
ctccggctcc tccttcctgg ctggtgccac ctgactgttg aagatggtcc ccgggagatt 1440
ttgatcaagg aaggagcccc ctcacttctg tgcaagtact tcctgcagca gtgggaactc 1500
acatcccctg gccatgatac ctcagtgctg ccagacagcg tggagatcgg cctacagacc 1560
tgttgccaca tcttcctcaa cctggtggtc accgctcccg ggctgatcaa gcgcgacgcc 1620
tgcttcacat cccttatgaa caccctgatg acgtcactgc cctcactagt gcagcagcaa 1680
ggaagactgc ttctagctgc caacgtggcc accttgggcc tcctaatggc ccggctcctt 1740
agcacctctc cagctctcca aggaactccg gcctcccgag gtttcttcgc agctgccatc 1800
ctctttctgt cacagtccca tgtggcacgg gccacccctg gctctgacca ggcggtgttg 1860
gccctgtccc ctgactatga gggcatctgg gccgacttgc aagagctctg gttcttgggc 1920
atgcaggcct tcacaggttg tgtccctctg ttgccctggc tggcccctgc cgccctgcgc 1980
tcccgctggc cacaggagct gctacagctg ctaggtagtg taagccccaa ctctgtcaag 2040
cccgagatgg tggctgccta ccagggcgtg ctcgtggaat tggcgcgggc aaaccggcta 2100
tgccgggagg ccatgaggct gcaggcgggt gaagaaacag ccagccatta ccgcatggct 2160
gctttggagc agtgcctgtc agagccctga 2190
<210> 18
<211> 963
<212> DNA
<213> Rattus norvegicus
<400> 18
atgagctcct gcaacttcac tcacgccacc ttcatgctta tcggtattcc aggactggag 60
gaagctcact tttggtttgg cttcccccta ctttccatgt acgctgtagc attgtttgga 120
aattgcattg tggtcttcat cgtgaggaca gagcggagcc tgcatgcgcc catgtatctt 180
tttctctgca tgctggcagc tattgatctg gctttgtcca cctctacaat gcccaagatt 240
ctcgccctct tttggtttga ctcccgggag attacttttg atgcctgtct cgcccagatg 300
ttcttcattc acgctctctc agcaattgaa tctaccatct tgctggccat ggcctttgac 360
cggtatgtgg ctatctgcca cccactgcgt cacgctgctg tgctcaacaa tacagtaaca 420
gtccaaatcg gcatggtggc tctggtccgg ggatccctat tctttttccc actcccactg 480
ctgatcaagc gactggcctt ctgccactcc aatgtgctct cccactccta ttgtgttcac 540
caggatgtga tgaagttggc ctatacagac acattgccca atgtagtcta tggtctaact 600
gccattctgc tagtcatggg tgtagatgtc atgttcatct ccttgtccta tttcctgatt 660
atacgagcag ttctgcaatt gccttccaag tctgagcgag ctaaggcatt tggaacctgt 720
gtgtcacaca ttggtgtagt cctggctttc tatgtcccac tcattggcct gtcagtagtg 780
caccgttttg gaaacagcct ggatcccatt gtgcatgttc tcatgggcga tgtctacctg 840
ctgctgcctc ctgtgatcaa tcccatcatc tacggtgcta agaccaaaca gatcagaaca 900
cgggtgctgg ctatgttcaa gatcagttgt gacaaggaca ttgaagctgg aggaaacacg 960
tga 963
<210> 19
<211> 618
<212> DNA
<213> Rattus norvegicus
<400> 19
atggcgctgc acatggttct tgtcgttttg agcctcctgc ccttgttgga agctcagaac 60
ccagaacctg ccaacatcac cctaggcata cctattacca atgagaccct gaaatggctc 120
tcagacaaat ggttttacat gggagcagct ttccgagacc ccgtgttcaa gcaggcagtt 180
caaacgatac agacggaata tttttacctt acccccaact tgataaacga cacaattgaa 240
cttcgggagt ttcagaccac agacgaccag tgtgtctata acttcaccca tctaggagtc 300
cagagagaga atgggacctt atccaagtgt gcaggagcag tgaaaatctt tgcccatttg 360
atagtgctga agaaacatgg gaccttcatg cttgccttta acctgacaga tgagaaccgg 420
gggctgtcct tctatgctaa aaagccagac ttgtccccag agctgcggaa aatattccag 480
caggctgtca aagatgtggg catggatgaa tcagaaatcg tatttgtcga ctggacaaag 540
gataagtgca gtgagcagca gaagcagcag ctggagctgg agaaggagac taagaaggag 600
accaagaagg atccttag 618
<210> 20
<211> 1362
<212> DNA
<213> Rattus norvegicus
<400> 20
atggcaggag ccggaggtgg cggctgcccg acgggcggca acgacttcca gtggtgcttc 60
tcgcaggtga agggcgctgt cgacgaggac gtggcggaag ccgacatcat ctccaccgtt 120
gagtttaact actctggaga ccttcttgca acaggagaca aaggtggcag agttgttatt 180
ttccaacggg aacaagagaa taaaggccgc gctcactcta ggggagagta caatgtttac 240
agtacctttc agagtcatga gccagagttt gactatttga aaagtctaga aattgaagaa 300
aaaattaata aaatcaggtg gttaccgcaa cagaatgctg ctcattttct actctctaca 360
aatgataaaa ctattaaatt atggaaaata agtgaacgag ataaaagagc agaaggttat 420
aacttgaaag atgaagatgg acgacttcga gacccattta gaattacggc actacgggtt 480
ccaatattga agcccatgga ccttatggta gaagcaagtc cacgacgaat ttttgcaaat 540
gctcatacat atcacataaa ttccatttca gtaaatagtg atcatgaaac atatctctct 600
gcagatgatc tgagaattaa cctatggcat ttagaaatca cagatagaag cttcaacatt 660
gtggacatca agcctgctaa catggaggag ctgacagaag tcatcactgc cgcggagttc 720
cacccacacc agtgcaatgt attcgtctac agcagcagca aggggaccat caggctgtgt 780
gacatgcgtt cttctgccct ctgtgatagg catgccaagt tttttgaaga gccagaagat 840
cccagcagta gatccttttt ctcagaaata atctcatcta tatctgatgt caagttcagc 900
cacagtggtc gatacatgat gaccagagac tatctgtcgg tgaaggtatg ggacctcaac 960
atggagggca ggcctgtcga gacccaccat gtacatgagt acctacgaag caagctctgc 1020
tccttgtatg agaatgactg catctttgac aagttcgagt gctgctggaa tggttcagac 1080
agtgccatta tgacggggtc ctacaacaac ttctttagaa tgtttgatag aaacactcgg 1140
agggatgtta cactggaagc ctcaagagag aacagcaagc cccgagccag cctgaagccc 1200
cggaaagtgt gttcaggggg taagaggaag aaggatgaga ttagcgtgga cagtttggac 1260
ttcaataaga agatccttca cacagcctgg caccccatgg agagcattat tgctgtagct 1320
gccaccaata acttgtatat attccaggac aaaattaatt aa 1362
<210> 21
<211> 3168
<212> DNA
<213> Rattus norvegicus
<400> 21
atggcagctg cttatcttga cccaaacttg aatcacacac caagttcgag tactaagact 60
cacctgggta ctggcacgga acggtcccct ggtgcaatgg aacgagtatt aaaggtcttt 120
cattattttg aaagcagtaa tgagccaacc acctgggcca gtattatcag gcatggagac 180
gctactgacg tcaggggaat cattcagaag atagtggaca gtcacaaagt aaagcacgtg 240
gcctgctatg gatttcgcct cagtcacctg cgatcggagg aggtgcactg gctgcatgtg 300
gacatgggtg tctccagtgt gagggagaaa tacgaactcg cccacccacc agaggagtgg 360
aaatatgagt tgagaattcg ttatttgcca aaaggatttc taaaccagtt tactgaagat 420
aagccaacat tgaatttctt ctatcaacag gtgaagagtg actacatgct agaaatagct 480
gatcaagtag accaagacat agctttgaag ttgggttgtt tggaaattag gcgatcctac 540
tgggagatga ggggcaacgc cctagagaag aagtccaact atgaagtgtt agagaaagat 600
gttggtttaa agcgattttt tcccaagagt ttactggatt ccgtgaaggc caaaacacta 660
agaaagctga tccagcaaac attcaggcag tttgccaacc ttaatagaga agaaagcatc 720
ctgaaattct ttgagattct ctctccagtg tacagatttg acaaagagtg cttcaagtgt 780
gcccttgggt caagttggat tatttctgtg gaactggcga tcggcccaga agaagggatc 840
agttacctga cagacaaggg ctgcaatccc acacacctag cggacttcaa ccaagtgcag 900
accatccagt actcaaacag tgaagacaaa gacaggaaag gaatgctaca actcaaaatc 960
gctggtgctc ctgagcctct gacagtgacg gccccatccc taaccattgc agagaacatg 1020
gctgacctga tcgatggata ctgccggctg gtgaacggag ccacgcagtc cttcatcatc 1080
agaccccaga aagaaggtga acgggcattg ccatcaatac caaagttggc caacaatgaa 1140
aagcaaggca tgcggacaca tgcagtctct gtgtcagaga cagatgacta tgccgagatc 1200
atcgatgagg aagacacata caccatgccc tcaaccaggg attatgagat tcagagagaa 1260
aggatagaac ttggacgctg tattggagaa ggccagtttg gagatgtaca tcaaggcgtg 1320
tacctgagcc cagagaatcc agctttggct gttgcaatca aaacatgtaa aaactgtact 1380
tcggacagcg tgagagagaa gttccttcaa gaagccttaa caatgcgcca gtttgaccat 1440
cctcacatcg tgaagctgat tggagtcatt acagagaacc cagtttggat aatcatggag 1500
ttgtgcacac ttggagagct gaggtcattt ttgcaagtaa ggaaatacag cttggatcta 1560
gcatctttga tcttatatgc ctatcagctt agtacagcac tcgcgtatct ggagagcaaa 1620
agatttgttc acagggacat tgctgcacgg aatgttctgg tgtcttcaaa tgattgtgta 1680
aaattaggag actttggatt atctcgatat atggaagaca gtacttacta taaagcttcc 1740
aaaggaaaat tacctattaa atggatggct ccagagtcaa tcaattttcg acgttttacc 1800
tcagctagtg acgtgtggat gtttggtgtg tgtatgtggg agatactgat gcatggcgtg 1860
aagccttttc aaggagtgaa gaacaatgat gtgatcggtc gaattgaaaa tggggaaaga 1920
ttaccaatgc ctccaaattg tcctcccacc ctctacagcc ttatgacgaa atgttgggcc 1980
tatgacccca gcagacggcc caggtttact gaactaaaag ctcagctcag cacaatcctg 2040
gaggaagaga aggtgcagca agaagaacgg atgaggatgg aatccagaag acaggcaaca 2100
gtgtcctggg actctggagg gtctgatgaa gcaccaccca agcccagcag acctggttat 2160
cctagcccga ggtccagtga aggattttat cccagcccac agcacatggt ccagaccaat 2220
cactatcaga tctctggcta cccaggttcc catggaatcc cagccatggc tggcagcatt 2280
tacccaggtc aggcatctct tctggaccag acagaattgt ggaatcacag acctcaggag 2340
atgtccatgt ggcagcccag tgtggaggac tcagcagctt tagatcttcg agggatggga 2400
caggtgcttc ctcctcacct gatggaagag cggctaatcc gacagcagca ggaaatggag 2460
gaagaccagc gctggctgga aaaggaagag cgattcctga aacctgatgt gaggctctct 2520
cgaggcagca tcgacaggga ggacgggagt tttcagggtc cgactggaaa ccaacacatc 2580
tatcagcctg tgggaaaacc agatcctgca gctccaccaa agaaaccacc tcgccctgga 2640
gcacctggcc acctaagcaa cttgtccagc atcagcagcc ctgcagaaag ctacaatgag 2700
ggtgtcaagc cgtggaggct tcagccccag gaaatcagcc cccctcccac tgccaacctt 2760
gaccgatcca atgacaaggt atatgaaaat gtgacgggcc tagtgaaggc tgtcattgag 2820
atgtccagca aaatccaacc agctcctcca gaagagtacg tccctatggt gaaggaagtt 2880
ggcctggccc tgcggacctt actggcaact gtggatgaga ccattcccat ccttccagcc 2940
agcacccatc gagagatcga gatggcacag aagctgctga actccgactt gggtgagctc 3000
atcagcaaga tgaagctggc gcagcagtat gtcatgacca gccttcagca ggagtacaag 3060
aagcagatgc tgacagctgc tcacgccctg gctgtggatg ccaagaatct acttgatgtt 3120
attgatcaag cgagactgaa aatgctaggg cagacacggc cacactga 3168
<210> 22
<211> 2655
<212> DNA
<213> Rattus norvegicus
<400> 22
atgcaacagt tgggagcctt tcccactgag tttgcgctgc attggcagct tggtcctggg 60
agaggccaag aaaagccttg taggcgaagc gcagggtcgc ttgagtttga aaaaattgaa 120
gaacctgaat ttattgcatt atgtcagaag ttaaaggtgc ccgatcatgt cagagagaga 180
gcttggctaa cgtgggagaa agtttcatct gtggatggaa tcctggaagg atatattcag 240
aagaagaagg aactctgggg catctgcatc ttcattgcag cagttgacct ggatgagatg 300
ccattcactt ttactgagct tcagaaaagc atagaaacca gtgtctataa attctttgac 360
ttattaaaag aaattgatac cagtaccaaa gttgataatg ctgtgtcaag gctattgaag 420
aagtacaatg tgttatgtgc actctacagc aaattagaac ggttatctac tgaaataaat 480
tctatgttgg tgctaaaagt ttcttggatc acctttttac tagctaaagg agaagtagta 540
cagatggaag atgatctggt gatctcattt cagttaatgt tgtgtgtact tgactatttt 600
atcaagctct cgcctcctgc gctgctcaga gagccgtaca aaacagctgc aacacccatt 660
aatggttcac ctcggacacc cagaagaggt cagaacagga gtgctcggat agcaaaacaa 720
ctagaaagtg atacaagaac tattgaagtt ctctgtaagg agcacgagtg taatgtagat 780
gagaaacatt acacaaaaaa gaataattgc caatttcttt cttttgagct tgaaagtctt 840
tctaaacgct acgaagaagt ttatcttaaa agcaaagatt tagatgcaag actatttttg 900
gatcatgaca aaacacttca gactgatact atagacagtt ttgaaacaga gagaactcca 960
cgaaaaagca accctgatga agaggcaaac atggttactc cacacactcc agttaggact 1020
gttatgaata ctattcaaca gttaatggtg attttaaatt ctgcaagtga tcagccatca 1080
gaaaatctga tttcctactt cagtaattgc acagtgaatc caaaagaaaa tatcctaaaa 1140
agagtaaagg atgttggaca catctttaaa gagaagtttg ctagcgctgt ggggcaggga 1200
tgtattgaca ttggagcaca gcgatataaa cttggggttc gattgtatta tcgtgtgatg 1260
gaatcgatgc ttaaatcaga agaagaacgt ttgtccattc agaattttag caaactccta 1320
aatgacaaca tctttcatat gtctttattg gcctgtgctc ttgaagttgt aatggctaca 1380
tatagcagga gtatgttaca gaatcttgat tctggaacag atttgtcctt cccgtggatt 1440
ctgaatgtac ttaatttaaa agcctttgat ttttacaaag tgattgaaag ttttatcaaa 1500
gtggaagcca acttgacaag agaaatgata aaacatttag aaagatgtga gcatcgaatc 1560
atggaatccc ttgcatggct ttctgattca cctttgtttg atctcataaa gcagtccaag 1620
gatggggaag gacctgatca ccttgagtct gcttgttctc tcagcctccc tctccagagt 1680
aaccacactg cagcagatat atctccaaag aaaagaactt ctactacacg tgtaaattct 1740
gcggcaaata cagagacgca agcagcctca gccttccata ctcagaagcc attgaaatct 1800
acctcccttt ccctgtttta caaaaaagtg taccgtctag catatctccg actaaataca 1860
ctgtgtgcgc gccttctgtc tgatcaccca gagctagaac acatcatctg gactctgttt 1920
cagcatacat tggaaaatga gtatgagctc atgaaagacc gacatttgga ccagattatg 1980
atgtgttcta tgtatggcat ctgcaaggtg aaaaacattg accttaaatt caaaatcatc 2040
gtaactgcgt ataaggatct tcctcacgct gcccaggaga cctttaaacg tgttttgatc 2100
agagaagagg agtttgattc cattatagtg ttctacaact cagttttcat gcagagacta 2160
aaaacaaata ttttacagta tgcctccacc aggcctccta ccttgtcacc aatacctcac 2220
attcctcgaa gcccttacaa gttctctagt tcacccttgc ggattcctgg aggtaacatc 2280
tatatatcac ccctaaagag tccttataaa atttcagaag gtctgccaac acccacaaaa 2340
atgactccaa gatcaagaat cttggtctca atcggtgaat catttgggac atccgagaag 2400
ttccagaaaa taaaccagat ggtgtgtaac agtgacagag tgctcaaaag aagtgctgaa 2460
ggcggcaatc cccccaaacc cctgaagaag ctgcgctttg acatcgaagg atccgatgaa 2520
gcagacggga gtaaacatct cccagcggag tccaaattcc aacagaaact ggcagaaatg 2580
acttctactc gaacacgaat gcaaaagcag aaactgaatg atagcatgga aatctcaaac 2640
aaggaggaaa agtga 2655
<210> 23
<211> 657
<212> DNA
<213> Rattus norvegicus
<400> 23
atggggacgc tgctggctct cgtggtgggc gcggtgctgg tatcctcagc ctgggggggc 60
tgcgtggagg tggattctga gaccgaggca gtgtatggga tgaccttcaa aatcctgtgt 120
atctcctgta agcgtcgtag tgagaccacc gccgagacct tcacggagtg gaccttccgc 180
cagaagggca cagaggaatt tgtcaagatc ctacgctatg agaatgaggt gctgcagctg 240
gaggaagatg agcgctttga gggccgtgtg gtgtggaacg gtagtcgggg caccaaggac 300
ctgcaggacc tgtccatctt catcaccaat gtcacctaca accactctgg cgactacgaa 360
tgtcacgtct accgtctcct cttctttgat aattacgagc acaacaccag cgtcgtcaag 420
aagatccacc tggaggtggt ggacaaggcc aacagagata tggcatccat cgtgtcagag 480
atcatgatgt acgtgctcat tgtggtgtta accatatggc tcgtggcgga gatggtgtac 540
tgctacaaga agattgctgc tgccacggaa gctgctgcac aagagaatgc ctcggaatac 600
ctggccatta cttccgagag caaagagaac tgtacaggcg tccaggtggc tgaatag 657
<210> 24
<211> 879
<212> DNA
<213> Rattus norvegicus
<400> 24
atggaagact cgatggacat ggacatgagc cctcttaggc ctcagaacta ccttttcggt 60
tgtgaactaa aggctgacaa agattatcac tttaaagtgg ataatgatga aaatgagcac 120
cagttatcat taagaacggt cagtttagga gcaggggcaa aagatgagtt gcacatcgta 180
gaggcagaag caatgaacta tgaaggcagc ccaattaaag taacactggc aactttgaaa 240
atgtctgtac aaccaacagt ttcccttggg ggcttcgaaa ttacaccacc tgtggtcttg 300
aggttgaagt gtggttctgg gcctgtgcac ataagtggac agcacctagt agctgtagag 360
gaagatgcag agtcagaaga tgaagatgag gaagatgtaa aactcttagg catgtctgga 420
aagagatctg ctcccggagg tggtaacaaa gtcccacaga aaaaagtaaa acttgatgaa 480
gatgatgatg aggatgatga agatgatgag gatgatgaag atgatgatga tgatgatttt 540
gatgaagagg aaactgaaga aaaggttcca gtgaagaaat ctgtacgaga taccccagcc 600
aaaaatgcac aaaaatcaaa ccaaaatggg aaagatttaa aaccatcaac accaaggtca 660
aagggtcaag agtccttcaa aaaacaggaa aaaactccca aaacacccaa aggacctagc 720
tctgtagaag acattaaggc aaaaatgcaa gcaagtatag aaaaaggtgg ttctcttccc 780
aaagtggaag ccaagttcat taattatgtg aagaattgtt tccggatgac tgaccaggag 840
gctattcaag atctctggca gtggaggaag tctctttaa 879
<210> 25
<211> 1515
<212> DNA
<213> Rattus norvegicus
<400> 25
atgaagaaga ccgaaatggg aaggttcaac atctccccgg atgaggacag cagcagttac 60
agctccaacg gtgacttcaa ctactcatac cccacgaagc aggctgctct aaaaagccat 120
tatgtggacg tggaccccga aaaccagaac tttttacttg aatcgaatct ggggaagaag 180
aagtacgaaa cagactttca tccaagtact acttcctttg gaatgtcagt atttaatctg 240
accaatgcga ttgtgggcaa tggaatcctt gggctttctt atgccatggc taatactgga 300
attgctcttt ttataattct cttgacgttc gtgtcgattt tttctctgta ctccgttcac 360
ctcctcctca agactgccaa cgaaggaggg tctttattat acgaacagtt gggacataag 420
gcatacggtc tggctgggaa gctggcagcc tccggatcga ttacaatgca gaacatcgga 480
gctatgtcaa gctacctctt catagtgaaa tatgagttac ctttggtgat caaggcgtta 540
atgaacattg aagatacgaa tgggctgtgg tatctgaacg gcgactatct ggtccttctg 600
gtgtccttcg tgctcattct cccattgtca ctgctgagaa atctaggata cttggggtat 660
accagcggcc tttctctgct ctgtatgata ttctttctga ttgtggtgat ttgcaagaag 720
tttcagattc cttgccctgt ggaagtggct ttgatggcta acgaaacggt gaatggcacc 780
tttacccagg tggctttggc agcgctggcg tccaacagca ccgcagccga tacctgcagg 840
ccccgttact ttatcttcaa ctcacagact gtgtatgctg tgcccatcct gacgttttcc 900
tttgtctgcc atcccgctgt ccttcccatc tatgaagagc tgaagagccg cagccggaga 960
aggatgatga acgtgtccaa gatttctttc ttcgccatgt ttctgatgta tttgcttgcc 1020
gccctcttcg gatacctgac attttacgag cacgtggagt cagaactgct acatacctac 1080
tctgcgatcg tgggaactga cattctcctc ctcgttgtcc gcctggctgt gctggtggct 1140
gtcaccctca ctgtccccgt cgtcattttc ccaatccgga gttcggtcac tcacttactg 1200
tgccctacaa aagagttcag ttggttccgg cacagtgtca ttactgtgac gatcctggcc 1260
ttcaccaatt tgctcgtcat ctttgtcccc actatcaggg acatcttcgg gttcattggt 1320
gcatcggccg ctgcaatgct gatcttcatc cttccgtctg ctttctacat caagttagtg 1380
aagaaagaac ccatgagatc cgtgcaaaag attggggctc tgtgttttct cctgagtggc 1440
gtagtcgtga tgattggaag catgggcttg attgtcctgg actgggtcca cgatgcctct 1500
gcaggcggac attaa 1515
<210> 26
<211> 1896
<212> DNA
<213> Rattus norvegicus
<400> 26
atgccgaggc cagtcctgtc agtcactgct ttttgtcatc ggcttggcaa acgggagagc 60
aaacgaagct tcatgggaaa cagcagcaac agttggtccc atgcatcatt ccccaagctg 120
gagctgggcc tgggacagcg tccctcccca ccccgggagt cgcctacctg ctccatctgt 180
ctggaaaggc ttcgagagcc tatctcactg gactgtggcc acgacttctg catccgatgc 240
ttcagcacac atcgcatccc aggctgtgag ctgccatgct gtcctgaatg ccggaaaatc 300
tgtaagcaaa agaagggcct tcgcagtcta ggggagagga tgaagctcct acctcagcgg 360
ccgctgcccc ctgcactgca ggagacctgt gctgtgagag cggagcgtct gctgttggta 420
cgcatcaatg cctctggagg cctcatcctc aggatgggag ccataaaccg ctgcctgaag 480
caccctctgg ccagggacac acctgtctgc ttgcttgctg tcctgggaga gcagcactca 540
ggaaagtcct tcctcttgga ccacttgctc agaggcttac caggcctgga atccggagac 600
agcactaggc ccagagcaga ggggtctctg cctggaatca gatggggtgc taatggtctc 660
acgaggggca tctggatgtg gagtcacccc ttcctgctgg gaaaagaagg gaagaaggtg 720
gctgtgttct tagtggacac aggagatgtc atgagcccag aactgagcag ggagacaagg 780
gtcaagctct gtgccctcac catgatgctc agttcgtacc agatcctcaa cacctcccaa 840
gagctgaagg acacagatct gggctatcta gagatgttcg ttcatgtggc tgaggtgatg 900
ggcaaacatt atgggatggt acccatccag catctggatc tcttagtccg tgactcttcc 960
catcacaata agtcagggca ggggcacgtg ggtgatatac tccagaagct gtccggcaaa 1020
taccccaagg tccaagagct gctcctaggg aaacgggccc gctgttacct ccttcctgct 1080
cctgagagac agtgggtgaa caaaggccaa gcaagcccag gaggcaacac agaagatgac 1140
ttctcccacc atttccgggc ctacatctcg gatgtgctga gcacagcccc tcagcatgct 1200
aagagccgct gccaagggta ctggagtgag ggtcgcgcca tggccagggg ggacagacgc 1260
ctactcacag ggcagcagct ggcacaggag atcaagaacc tctccggctg gatggggaag 1320
agtgggccca gtttcagctc tccagatgag atggctgctc aacttcatga cctgaggaaa 1380
gtggaagccg ccaagaagga gtttgaagag tatgtgagac agcaggacat agccaccaag 1440
cgcatcttct ctgcactacg agtactgccc gacactatga ggaacctcct ctctacccag 1500
aaggatgcta tcttggcccg ccatggtgtg gccctgttgt gcaaggagag agagcagacc 1560
ttggaggccc tggaagccga gctgcaggca gaagccaagg ccttcatgga ctcctacaca 1620
atgcgcttct gtggccacct ggccgcggta gggggcgctg taggtgctgg actcatgggc 1680
ctggcagggg gtgtggtggg cgccggtatg gcggcagcag cgttggctgc agaagctggg 1740
atggtggcag ccggggcagc ggtgggtgcc actggggctg ctgtagttgg gggtggtgtg 1800
ggtgctgggc tggccgcgac ggtgggctgc atggagaaag aggaagatga gagagttcaa 1860
ggaggagacc gagagcccct actccaggaa gaataa 1896
<210> 27
<211> 2064
<212> DNA
<213> Rattus norvegicus
<400> 27
atggagcaaa gctacggagg ttatggggca tggagtgctg gacctgccaa cacccagggt 60
acatatggaa gtggtgtggc cagctggcaa ggttatgaaa actacagcta ctacaatgcc 120
cagaacacca gtgtccctac aggaacaccc tatagttatg gcccagcctc gtgggaggcc 180
accaaggcca gtgatggtgg cctggcagct gggagttctg ctatgcatgt ggcctctttt 240
gccccagagc catgcaccga caactctgac tcgctcattg ccaagatcaa tcaacgtttg 300
gacatgttgt ccaaggaagg aggcaggggt gggatcagca gcggtgggga gggcatgcag 360
gaccgagaca gctccttccg cttccagcca tatgagtcct acgactccag gccctgtatg 420
cctgagcata ctccctaccg ccccagctac agttacgatt atgactttga cttgggaact 480
gaccgcaatg gtagttttgg cgggacattc aacgactgtc gggacccaac cccagagcga 540
ggcgcccttg atggtttctt aaggggccgg ggccagggcc gcttccagga ccggagcaac 600
tcgagcacct tcatacgtag tgaccccttc atgccaccct cagcctcctc agagccctta 660
tccaccacct ggagtgagct gaactacatg ggtggacgtg gtctaggtgg gccctccacc 720
aacaggccgc ctccttccct cttctcccag tccatggccc ctgactacag catgatgggc 780
atgcaggggg tgggcggttt tggtggcacc atgccttatg gatgtggccg gtcccagact 840
cggatacggg attggcccag aaggaggggg tttgaacgct ttggaccaga caacatgggc 900
aggaagcgga agccgtttcc attgtatgaa gaacctgatg ccaagctggc ccgtgctgac 960
agtgaaggag acctctctga aaacgatgat ggagctggtg acttacggtc aggagatgaa 1020
gaatttaggg gggaggacga cctctgtgac tcccggaagc agagaggaga aaaggaggac 1080
gaggatgagg atgtgaagaa gagacgggag aagcaaagga ggagagatcg gatgcgggac 1140
cgagcagctg acaggattca gtttgcctgt tctgtgtgca aatttcgtag ctttgaagat 1200
gaagaaatcc aaaagcatct gcaaagtaaa tttcataaag agaccttgcg gtttataagt 1260
accaaactac ctgacaagac agtagaattt ctccaggagt atatcataaa caggaataag 1320
aaaattgaga aacggcgtca ggagttgttg gagaaggaaa gccctaaacc caaaccagat 1380
ccattcaaag ggattggcca ggagcatttc ttcaaaagga ttgaagccgc acactgcctg 1440
gcctgtgaca tgctgattcc tgcacagcac cagctcctgc agcggcatct gcactctgtg 1500
gaccataacc ataatcgaag gttggctgct gaacaattca agaaaacaag tctccatgtg 1560
gctaagagtg ttctgaacaa caagcatata gtgaagatgt tagaaaaata cctcaagggc 1620
gaggatcctt ttgtcaatga aactgctgat cttgagacag aaggagatga gaacttagga 1680
gaggagaagg agacaccaga ggaggtagct gcggaagtct tagcagaggt gatcacagca 1740
gcggtgaagg ctgtagaggg ggatggagaa ccagctgcag agcatagtga cgtcctagct 1800
gaagtggaag ggcctgtgga caccgccgag gctggtagtg actcccacac tggaaagctg 1860
ctagaagaac agacctgtga aacagcatct gaaaccagga acatggaaga catggccaga 1920
ggtgaggctg ctgaggccag aaatgaagca gctgtgccag cagcagccgc cggaagccca 1980
gtacctgtca tagccatccc aggaatcctg gaagatgagc tggaacaaac tgatgcagag 2040
gccaaagata ctcccacaga ataa 2064
<210> 28
<211> 1446
<212> DNA
<213> Rattus norvegicus
<400> 28
atgaatgagg tatctgtcat caaagaaggc tggctccaca aacgtggtga atacatcaag 60
acctggaggc cccggtactt ccttctgaag agtgatggat cttttattgg gtataaagag 120
agacctgagg cccccgacca gaccctaccc ccccttaaca atttctctgt agcagaatgc 180
cagctgatga agactgagag gccacgaccc aacacctttg tcatacgctg cctgcagtgg 240
accacagtca tcgagaggac cttccatgtc gactctccag atgagaggga agagtggata 300
cgggctatcc agatggtagc caacagtctg aagcagcggg gccccgggga ggatgccatg 360
gattacaagt gtggctcccc cagtgactct tccacatctg agatgatgga ggtagcggtc 420
agcaaggcac gggccaaagt gaccatgaac gacttcgatt atctcaaact cctcggcaag 480
ggcaccttcg gcaaagtcat tctagttcga gagaaggcca ctggccgcta ttatgccatg 540
aagatcctgc ggaaggaggt catcattgca aaggatgaag tcgcccacac agtcacagag 600
agccgagtcc tacagaatac caggcacccc ttccttacag ccctgaagta tgccttccag 660
acccatgacc gcctgtgctt tgtgatggag tatgccaacg ggggcgacct gtttttccac 720
ctctctcggg agcgagtctt cacggaggat cgggcacgct tttatggtgc agagattgtg 780
tcagctctgg agtacttgca ctcgacggat gtggtgtacc gcgacatcaa gctggaaaac 840
cttatgctgg acaaagatgg ccacatcaag atcactgact ttggcttgtc caaagagggc 900
atcagtgatg gggccaccat gaaaaccttc tgtggtaccc cggagtactt ggcgcctgag 960
gtgctagagg acaatgacta cgggcgtgca gtggactggt ggggactggg cgtggtcatg 1020
tacgagatga tgtgcggccg cctgcccttc tacaaccagg accacgagcg cctcttcgag 1080
ctcatcctca tggaggagat ccggttccca cgcacgcttg ggccagaggc caagtccctg 1140
ctggctggac tgctcaagaa ggaccccaag cagaggctcg gtgggggtcc cagtgatgcc 1200
aaggaggtca tggagcatcg gttcttcctc agcatcaact ggcaggatgt ggtacagaag 1260
aagctcctgc cacccttcaa acctcaggtc acttcagaag tggacacaag gtactttgat 1320
gatgaattca ccgcccagtc catcacaatc acacccccag accgatatga cagcctgggc 1380
tcgctggaac tggaccagcg cacacacttc ccccagttct cctactcagc cagcatccga 1440
gagtga 1446
<210> 29
<211> 2658
<212> DNA
<213> Rattus norvegicus
<400> 29
atggcaagac aaggctgtct cgggtcattc caggtaatat ccttgttcac ttttgccatc 60
agtgtcaata tctgcttagg attcacagca agtcgaatta agagggcaga atgggatgaa 120
ggacctccca cagtgctgtc tgactctcca tggaccaaca cctctggatc ctgcaaaggt 180
agatgctttg agcttcaaga ggttggccct ccagactgtc ggtgtgacaa cctgtgtaag 240
agctacagca gctgctgcca cgatttcgat gagctctgtt tgaaaacagt ccgaggctgg 300
gagtgcacca aagacagaag tggggaagta cgaaacgagg aaaatgcctg tcactgccca 360
gaagactgct tgtccagggg agactgctgt accaactacc aagtggtctg caaaggagaa 420
tcacactggg tagatgatgc tgcgagaaat caaagttccg aatgcctgca ggtttgtccg 480
cctccgttaa tcatcttctc tgtggatggt ttccgtgcat catacatgaa gaaaggcagc 540
aaggttatgc ccaacattga gaaactgcgg tcctgtggca cccatgtccc ctacacgagg 600
cctgtgtacc ccacaaaaac cttccctaat ctatatacgc tggccactgg tttatatccg 660
gaatcccatg gaattgtcgg taattcaatg tatgatcctg tctttgatgc ttcgttccat 720
ctacgagggc gagagaagtt taatcatagg tggtggggag gccaaccgct atggattaca 780
gccaccaagc aaggggtgag agctggaaca ttcttttggt ctgtgagcat ccctcatgaa 840
cggaggatcc taaccattct tcagtggctt tctctgccag acaacgagag gccttcagtt 900
tatgccttct actcagagca gcctgatttt tctggacaca agtacggccc ttttggccct 960
gagatgacaa atcctctgag ggagattgac aagaccgtgg ggcagttaat ggatggactg 1020
aaacaactca ggctgcatcg ctgtgtgaac gttatctttg ttggagacca tggaatggaa 1080
gatgtgacat gtgacagaac tgagttcttg agcaactatc tgactaatgt ggatgacatt 1140
actttagtgc ctggaactct gggaagaatt cgagccaaat ctatcaataa ttctaaatat 1200
gaccctaaaa ccattattgc taacctcacg tgcaaaaaac cggatcagca ctttaagcct 1260
tacatgaaac agcaccttcc caaacggttg cactatgcca acaacagaag aattgaagac 1320
atccatttat tggtcgatcg aagatggcat gttgcaagga aacctttgga cgtttataag 1380
aaaccatcag gaaaatgttt tttccagggt gaccacggct ttgataacaa ggtcaatagc 1440
atgcagactg ttttcgtagg ttatggccca acttttaagt acaggactaa agtgcctcca 1500
tttgaaaaca ttgaacttta caatgttatg tgcgatctcc taggcttgaa gcccgctccc 1560
aataatggaa ctcatggaag cttgaatcac ctactgcgta caaatacctt taggccaacc 1620
atgccagacg aagtcagccg acctaactac ccagggatta tgtaccttca gtccgagttt 1680
gacctgggct gcacctgtga cgataaggta gagccaaaga acaaattgga agaactcaat 1740
aaacgtcttc ataccaaagg atcaacagaa gctgaaaccg ggaaattcag aggcagcaaa 1800
catgaaaaca agaaaaacct taatggaagt gttgaaccta gaaaagagag acatctcctg 1860
tatggacggc ctgcagtgct ctatcggact agctatgata tcttatacca tacggacttt 1920
gaaagtggtt atagtgaaat attcttaatg cctctctgga catcgtatac catttctaag 1980
caggctgagg tctccagcat cccagaacac ctgaccaact gtgttcgtcc tgatgtccgt 2040
gtgtctccag gattcagtca gaactgttta gcttataaaa atgataaaca gatgtcatat 2100
ggattccttt ttcctcccta cctgagctcc tccccagaag ctaagtatga tgcattcctc 2160
gtaaccaaca tggttccaat gtaccccgcc ttcaaacgtg tttgggctta tttccaaagg 2220
gttttggtga agaaatatgc ttcagaaagg aatggagtca acgtaataag tggaccgatt 2280
tttgactaca attacgatgg cctacgtgac actgaagatg aaattaaaca gtatgtggaa 2340
ggcagctcta tacctgtccc cacccactac tacagcatca tcaccagctg cctggacttc 2400
actcagcctg cagacaagtg tgacggtccc ctctctgtgt cttccttcat ccttcctcac 2460
cgacccgaca atgatgagag ctgtaatagc tccgaggatg agtcgaagtg ggtagaggaa 2520
ctcatgaaga tgcacacagc tcgggtgcgg gacattgagc acctcactgg tctggatttc 2580
taccggaaga ctagccgtag ctattcggaa attctgaccc tcaagacata cctgcataca 2640
tatgagagcg agatttaa 2658
<210> 30
<211> 324
<212> DNA
<213> Rattus norvegicus
<400> 30
atgtcttacc aggagcccca gctctgggca ggtgacaacc agggcctgct gcacgtcttc 60
gccaaccaag atggctgctt ccagcttgtt cggacctttg atgtgggtca ccagtctcag 120
atcacaggga tcaaacactc cctggggact ctgtacacaa catctactga caagactatt 180
cgggttcatg tgcccacaga tccacctaag accatctgta cccgaaggca ccacaacgtg 240
ttaaatggga tctgtgctga gggcaacata gtggtggctg cctctggtgg cctgtcattg 300
gaggtctgga ggctgttggc ctga 324
<210> 31
<211> 1518
<212> DNA
<213> Rattus norvegicus
<400> 31
atggaggcct cggccgattc ctctgaggcc tccgccgcct gccgcttctt cctagagggc 60
cgctgtcgct ttggtgcgcg ctgccgtcag ccacatcccg gggccccggc gccgtccccc 120
gaggttgcgc agcctgaggc ccggtctaag aagcctgctc tgcgtactgc tgctgacgtc 180
atccggcgta tccgctggga cccgcgcctg gatcccgctg acttttctgt gggctacact 240
gaccgcttcc tgggtgtgca ggaagagcca ttctgtgcct tttgctggga cgagccgcta 300
gcagcgctcg gacccggcgt tttggcggtg ccgcagcacc gcattcgcta cttccgcttc 360
cgcggccgcc tggtgtggga ccgtgcctcc cgtactgacc ttatttttgg ctcgggctct 420
gtggctggac ggggacccac catcctcgat gcgctggacg accgggacga gcattggaga 480
gaggttaagg cagaaattcc ggacacagag aaaacagggg tgggtttcga ggatctggac 540
acccagggtg cccctgagga agggggtgga aacccgacca cgactgggct tgatacgggc 600
ctagagacac aggaagaggg tggggcaatc aaagagacca gaactgggct tgattcgggc 660
ctagagacac ccgaagaagg tgggacaatc aaagaggcca gaactgagct tgattccagc 720
ctggagacac cggaagtaga tgggccaacc aaagagactg tactgaatgg gaccactgag 780
ttagaaacac cagacccaag catatgctgc tcaggagtaa aggagatctc tgtacaagtg 840
cccaaagcca cagtgctttc acagtggcag gtgcaggtct tggaaacttc aggtctttct 900
gcagacgaga tggaaagtgt gtgggatcca ggtgcttggc ctgatgacag aagggcccct 960
cgcaaacccc ggcctacaca ttttgtggca ctgatggtga cagagcctgg gcttagggct 1020
gaggtggtca aggcccaaga gcatctggtc cggattgccc cttattgtgc cgagttcctg 1080
gtaccagcac aggccctgca cctgacagtg gtcttgctaa ggataacagg ccctggggag 1140
gaggctgcag cggttagagc tcttcggaga gccatcttga aaccagggct tcaggcaccc 1200
tccgagttac agttccggga cttgattctt ctgggccatc atgtgctctg tgccacacct 1260
tccccaacac tggcaagcat ggtccaaaca ctgaatcaga ggctagaggc cgaagggctt 1320
agagtggtgc agctgccaga actacaacca cacctcacgc tggctaaggt accacatgga 1380
acccaggtct gcctccccaa gcctgagtat atcctgaatg aggagctagg aaggcagccc 1440
ctagagaaac tctggctgtg cagaatgggc agagcagggc agagctacct gcccctggct 1500
caaattcccc tgaactga 1518
<210> 32
<211> 543
<212> DNA
<213> Rattus norvegicus
<400> 32
atggggatcc cagtggggaa gtcgatgttg gtgcttctca tctctttggc cttcgccttg 60
tgctgcatcg ctgcttaccg ccccagcgag actctgtgcg gaggggagct tgttgacacg 120
cttcagtttg tctgttcgga ccgcggcttc tacttcagca ggccttcaag ccgtgccaac 180
cgtcgcagcc gtggcatcgt ggaagagtgc tgcttccgca gctgcgactt ggccctcctg 240
gagacatact gtgccacccc cgccaagtcc gagagggacg tgtctacctc tcaggccgta 300
cttccggacg acttccccag ataccccgtg ggcaagttct tcaaattcga cacctggaga 360
cagtccgcgg gacgcctgcg cagaggcctg cctgccctcc tgcgtgcccg ccggggtcgc 420
atgcttgcca aagagctcga agcgttcaga gaggccaagc gccaccgtcc cctgatcgtg 480
ttaccaccca aagaccccgc ccacggggga gcctcttcgg agatgtccag caaccatcag 540
tga 543
<210> 33
<211> 489
<212> DNA
<213> Rattus norvegicus
<400> 33
atgaaaattt tgaaaccata tatgaggaat acatccatct tgtactacct gtgtttcctt 60
ctcaacagtc acttcttaac tgaggctggc atccatgtct tcattttggg ctgtgtcagt 120
gtaggtctcc ctaaaacaga ggccaactgg atagatgtaa gatacgatct ggagaaaatt 180
gaaagtctta ttcaatttat tcatattgat actactctat acactgacag tgactttcat 240
cccagttgca aagttactgc aatgaactgc tttctcctgg aattacaggt tattttgcac 300
gagtacagta acatgactct taatgaaaca gtaagaaacg tgctctacct tgcaaacagc 360
actctgtctt ctaacaagaa tgtaatagag tctggctgca aggaatgtga ggagctggag 420
gagagaaact tcacggagtt tttgcagagt tttatacata ttgtccaaat gttcatcaac 480
acgtcctga 489
<210> 34
<211> 915
<212> DNA
<213> Rattus norvegicus
<400> 34
atgctgccga gattgggcgg ccccgcgctg ccgctgctcc tgccgtcgct gctcttgctg 60
ctgctcttgg gcgcgggcgg ttgcggtcct ggggtgcgcg ccgaggtgct gttccgctgc 120
ccaccctgca cgcccgagcg tctggccgcc tgcggacccc cacccgacgc gccctgcgcc 180
gagctggtgc gagagcccgg ctgcggttgc tgctccgtgt gcgcacgaca ggagggcgaa 240
gcttgcggcg tctacatccc gcgctgcgcc cagacgttac gctgttaccc caacccgggc 300
tccgagctgc ccctgaaggc actggtcacc ggcgcgggta cctgtgaaaa gagacgcgtg 360
ggcgccaccc cacagcaggt tgcagacagt gaggatgacc actcggaggg aggcctggtg 420
gagaaccatg tggacggaac catgaacatg ttgggaggca gcagtgctgg ccggaagccc 480
cctaagtcag gcatgaagga actggctgtg ttccgggaga aggtcaacga gcagcaccgg 540
cagatgggca aaggtgccaa acacctcagc ctggaggagc ccaagaagct gcgcccacct 600
cctgccagga ccccttgcca gcaggagctg gaccaggtcc tggagcgcat ctccaccatg 660
cgccttccgg atgatcgggg tcctctggaa catctctact ccctgcatat ccccaactgt 720
gacaagcatg gcctgtacaa cctcaaacag tgcaagatgt ctctgaatgg acagcgtggg 780
gagtgctggt gtgtgaaccc caatactggg aagccaatcc agggagctcc caccatccgg 840
ggagaccccg agtgccatct cttctacaac gagcagcagg agaatgatgg ggctcacgcc 900
caaagggtgc agtaa 915
<210> 35
<211> 555
<212> DNA
<213> Rattus norvegicus
<400> 35
atgcgtgaat ataagctagt cgttcttggc tcaggaggtg ttgggaagtc ggctctgact 60
gtacagtttg ttcaaggaat ttttgttgaa aaatatgatc ctacgataga agattcttat 120
agaaagcaag ttgaagtaga tgcacagcag tgtatgcttg aaatcctgga tgctgcagga 180
acggagcagt ttacagccat gagagatctg tacatgaaga acgaacaagg ctttgcgttg 240
gtttactcca tcacaacgca aatcgactgt aatgacttac aaggtctgag agagcagatt 300
cttcgggtta aagacactga cgatgtccca atgattctgg ttggtaacaa atgcgacctg 360
gaagacgaaa gagttgtccc caaggaacaa ggtcagaacc tggcaagaca gtggagcaac 420
tgcgctttct tagagtcctc cgccaagtcc aagataaatg ttaacgagat cttttatgac 480
ctagtgcggc aaattaacag aaaaacccca gtgcctggga accgtcgcaa aaagtcacca 540
tgtcagctgc tttaa 555
<210> 36
<211> 444
<212> DNA
<213> Rattus norvegicus
<400> 36
atggcttccc ttcgcctgtt cctcctctgc ctcgctggac tgatatttgc gtctgaagct 60
ggccctgggg gtgctggaga atccaagtgt cctctgatgg tcaaagtcct ggatgctgtc 120
cgaggcagcc ctgctgtcga tgtggccgtg aaagtgttca aaaagactgc agacggaagc 180
tgggagccgt ttgcctctgg gaagaccgcc gagtctggag agctgcacgg gctcaccaca 240
gatgagaagt tcacggaagg ggtgtacagg gtagaactgg acaccaaatc gtactggaag 300
gctcttggca tttccccatt ccatgaatac gcagaggtgg ttttcacagc caatgactct 360
ggtcatcgcc actacaccat cgcagccctg ctcagcccgt actcctacag caccactgct 420
gtcgtcagta acccccagaa ctga 444
<210> 37
<211> 2517
<212> DNA
<213> Rattus norvegicus
<400> 37
atggaacaac gggctagctt agactcagag gagtctgagt ccccacccca agagaactcc 60
tgcctggacc ctccagacag agaccctaac tgcaagccac ctccagtcaa gccccacatc 120
ttcactacca ggagtcgtac ccggcttttt gggaagggtg actcggagga ggcctctccc 180
ctggactgcc cttatgagga aggcgggctg gcttcctgcc ctatcatcac tgtcagctct 240
gttctaacta tccagaggcc tggggatgga cctgccagtg tcaggccgtc atcccaggac 300
tccgtctccg ctggtgagaa gcccccgagg ctctatgatc gcaggagcat cttcgatgct 360
gtggctcaga gtaactgcca ggagctggag agcctgctgc ccttcctgca gaggagcaag 420
aagcgcctga ctgacagcga gttcaaagac ccagagacag gaaagacctg tctgctaaaa 480
gccatgctca atctgcacaa tgggcagaat gacaccatcg ctctgctcct ggacgttgcc 540
cggaagacag acagcctgaa gcagtttgtc aatgccagct acacagacag ctactacaag 600
ggccagacag cactgcacat tgccattgaa cggcggaaca tgacgctggt gaccctcttg 660
gtggagaatg gagcagatgt ccaggctgcg gctaacgggg acttcttcaa gaaaaccaaa 720
gggaggcctg gcttctactt tggtgagctg cccctgtccc tggctgcgtg caccaaccag 780
ctggccattg tgaagttcct gctgcagaac tcctggcagc ctgcagacat cagcgcccgg 840
gactcagtgg gcaacacggt gcttcatgcc ctggtggagg tggcagataa cacagttgac 900
aacaccaagt tcgtgacaag catgtacaac gagatcttga tcctgggggc caaactccac 960
cccacgctga agctggaaga gatcaccaac aggaaggggc tcacgccact ggctctggct 1020
gctagcagtg ggaagatcgg ggtcttggcc tacattctcc agagggagat ccatgaaccc 1080
gagtgccgac acctatccag gaagttcacc gaatgggcct atgggccagt gcactcctcc 1140
ctttatgacc tgtcctgcat tgacacctgt gaaaagaact cggttctgga ggtgatcgct 1200
tacagcagca gtgagacccc taaccgtcat gacatgcttc tcgtggaacc cttgaaccga 1260
ctcctacagg acaagtggga cagatttgtc aagcgcatct tctacttcaa cttcttcgtc 1320
tactgcttgt atatgatcat cttcaccgcg gctgcctact atcggcctgt ggaaggcttg 1380
cccccctata agctgaaaaa caccgttggg gactatttcc gagtcaccgg agagatcttg 1440
tctgtgtcag gaggagtcta cttcttcttc cgagggattc aatatttcct gcagaggcga 1500
ccatccctca agagtttgtt tgtggacagc tacagtgaga tacttttctt tgtacagtcg 1560
ctgttcatgc tggtgtctgt ggtactgtac ttcagccaac gcaaggagta tgtggcttcc 1620
atggtgttct ccctggccat gggctggacc aacatgctct actatacccg aggattccag 1680
cagatgggca tctatgctgt catgattgag aagatgatcc tcagagacct gtgccggttt 1740
atgttcgtct acctcgtgtt cttgtttgga ttttccacag ctgtggtgac actgattgag 1800
gatgggaaga ataactctct gcctatggag tccacaccac acaagtgccg ggggtctgcc 1860
tgcaagccag gtaactctta caacagcctg tattccacat gtctggagct gttcaagttc 1920
accatcggca tgggcgacct ggagttcact gagaactacg acttcaaggc tgtcttcatc 1980
atcctgttac tggcctatgt gattctcacc tacatccttc tgctcaacat gctcattgct 2040
ctcatgggtg agaccgtcaa caagattgca caagagagca agaacatctg gaagctgcag 2100
agagccatca ccatcctgga tacagagaag agcttcctga agtgcatgag gaaggccttc 2160
cgctctggca agctgctgca ggtggggttc actcctgacg gcaaggatga ctaccggtgg 2220
tgtttcaggg tggacgaggt aaactggact acctggaaca ccaatgtggg tatcatcaac 2280
gaggacccag gcaactgtga gggcgtcaag cgcaccctga gcttctccct gaggtcaggc 2340
cgagtttcag ggagaaactg gaagaacttt gccctggttc cccttctgag ggatgcaagc 2400
actcgagata gacatgccac ccagcaggaa gaagttcaac tgaagcatta tacgggatcc 2460
cttaagccag aggatgctga ggttttcaag gattccatgg tcccagggga gaaataa 2517
<210> 38
<211> 621
<212> DNA
<213> Rattus norvegicus
<400> 38
atgcttcctc ctgccattca tctctctctc attcccctgc tctgcatcct gatgaaaaac 60
tgtttggctt ttaaaaatga tgccacagaa atcctttatt cacatgtggt taaacctgtt 120
tcagcacacc ccagcagcaa cagcaccttg aatcaagcca ggaatggagg caggcacttc 180
agtagcacgg gactggatcg aaatagtcga gttcaagtgg gctgcaggga actgcggtcc 240
accaaataca tctcggatgg ccagtgcacc agcatcagcc ctctgaagga gctggtgtgc 300
gcgggtgagt gcttgccctt gccagtgctt cccaactgga tcggaggagg ctacggaaca 360
aagtactgga gccggaggag ctcccaggag tggcggtgtg tcaacgacaa gacgcgcacc 420
cagagaatcc agctgcagtg tcaggacggc agcacacgca cctacaaaat caccgtggtc 480
acagcgtgca agtgcaagag gtacacccgg cagcacaacg agtccagcca caactttgaa 540
agcgtgtctc ccgccaagct cgcccagcac cacagagagc ggaagagagc cagcaaatcc 600
agcaagcaca gtctgagcta g 621
<210> 39
<211> 279
<212> DNA
<213> Rattus norvegicus
<400> 39
atgaagatct ctgcagctgc atccctcacc gtcatcctcg ttgcagccgc cctctgcacc 60
cccgtacctg cctccccata tggctcggac accactccct gctgctttgc ctacctctcc 120
ctcgcactgc cccgtgccca cgtgaaggag tatttttaca ccagcagcaa gtgctccaac 180
cttgcagtcg tctttgtcac tcgaaggaac cgccaagtgt gtgccaaccc agagaagaag 240
tgggttcaag aatacatcaa ctatttggag atgagctag 279
<210> 40
<211> 4416
<212> DNA
<213> Rattus norvegicus
<400> 40
atggcccgct tggctgcagc actctggagt ctctgtgtga cgactgtcct cgtcacctct 60
gctacccaag gcctgagccg ggctggactc ccatttggat tgatgcgccg ggagctagca 120
tgcgaaggct accccattga gctgcggtgc ccgggcagtg acgtcatcat ggtggagaat 180
gcaaactatg ggcgcacaga tgacaagatc tgcgatgccg acccttttca gatggagaac 240
gtgcagtgct acctgcctga cgccttcaaa atcatgtcac agagatgtaa taaccgaacc 300
cagtgtgtgg tggtggccgg ctctgacgcc tttcctgacc cctgtcctgg aacctacaag 360
tacctggagg tgcagtacga ctgtgtccct tacaaagtgg agcagaaagt cttcgtgtgc 420
ccagggacac tgcagaaggt gctggagccc acctccacac atgaatcgga gcaccagtct 480
ggcgcatggt gcaaggaccc actgcaggca ggtgaccgta tctacgttat gccctggatc 540
ccctaccgca cggacacact gaccgagtat gcttcctggg aggactatgt ggctgcacgc 600
cacaccacca cgtacagact gcccaaccgt gtagatggca ctggctttgt ggtatatgat 660
ggtgccgtct tctataacaa ggaacgtact cgcaacattg tcaaatatga cctgcggacc 720
cgcatcaaga gcggagaaac agtcataaac acagccaact accacgacac ctcaccttat 780
cgctggggag gcaaaaccga cattgacctg gcagtggatg agaacgggct gtgggtcatc 840
tatgccaccg aggggaacaa cgggcgtctg gtggtgagcc agctcaaccc ctacacactg 900
cgtttcgagg gcacctggga aacaggctat gacaagcgct cagcctccaa tgccttcatg 960
gtgtgtggtg tcctctatgt gctgcgctct gtttatgtgg atgacgacag tgaggcagca 1020
ggcaaccgcg tggactatgc ctttaacacc aatgcaaacc gagaggagcc cgtcagtctc 1080
gccttcccca acccctacca gtttgtatct tctgttgact acaatccccg ggacaaccag 1140
ctgtatgtgt ggaacaacta tttcgtggtg cgctacagcc tggagtttgg acccccagat 1200
cccagtgctg gcccagccac ttccccacct ctcagtacca ccaccacagc tcggcctacg 1260
cccctcacca gcacagcctc acctgcagcc accactccac tccgccgggc gcccctcacc 1320
acgcacccag taggtgccat caaccagctg ggacctgacc tgcctccagc cacagcccca 1380
gcacccagta cccggcggcc tccagccccc aatctgcatg tgtcccctga gctcttctgt 1440
gaaccccgag aggtccggcg ggtccagtgg ccagctaccc agcagggtat gctggtagag 1500
agaccttgcc ccaagggaac tcgaggaatt gcctcgttcc agtgcctccc agctctgggg 1560
ctctggaatc ctcggggccc tgacctcagc aactgcactt ccccctgggt caaccaagtc 1620
gcccagaaga tcaagagtgg agagaatgca gccaacattg ctagtgagct ggcccgccac 1680
acgcggggct ccatctatgc tggggacgtg tcctcatcgg tgaagctgat ggagcaactg 1740
ctagatatcc tggatgccca gctccaggcc ctacggccca ttgaacgaga gtcagctggc 1800
aagaactaca ataagatgca caagcgagag agaacctgca aggactatat caaggctgtg 1860
gtggagacag tggacaacct gcttcggcca gaggcacttg agtcatggaa agacatgaat 1920
gccaccgaac aggtccatac ggccaccatg ctcctagatg tcttagagga gggtgccttc 1980
ctgctggccg acaatgtcag agaacctgct cgcttcttgg ctgccaagca gaatgtggtc 2040
ctggaggtca ctgtcctgag cacagagggt caagtgcagg agttggtgtt cccccaggag 2100
tatgccagtg agagctccat tcagctgtcc gccaacacca tcaagcagaa cagccgcaat 2160
ggtgtggtga aggttgtctt cattctctac aacaacctgg gcctcttctt gtccacggag 2220
aatgccacag tgaagctggc aggtgaggca gggaccggtg gccctggagg tgcctccctg 2280
gtggttaact cacaggtcat cgcagcatcc atcaataagg agtccagccg tgtcttcctc 2340
atggaccctg tcatctttac tgtggcccac ttggaggcca agaaccactt caatgcaaac 2400
tgctccttct ggaactactc agagcgctcc atgctgggct actggtcaac ccagggctgc 2460
cgactggtgg agtccaataa gacccatacc acatgtgcct gcagccacct caccaacttc 2520
gcagtgctca tggctcaccg agagatctac caaggccgta ttaatgagct gttgctgtca 2580
gtcatcacct gggttggcat tgtcatctcc ctggtctgtc tggctatctg catctccacc 2640
ttctgcttcc tgcggggcct gcagaccgac cgcaacacca tccacaagaa cctgtgcatc 2700
aacctcttcc ttgcagagct gctcttcctg gttggaatag acaaaactca gtatgaggtc 2760
gcctgcccta tctttgcggg cctgctgcac tacttcttcc tggccgcctt ctcctggctg 2820
tgcctagagg gcgtgcacct ctacctcctg ctggtcgagg tgttcgagag cgaatattca 2880
cgcaccaagt actattacct gggcggctac tgcttcccag ccctggtggt aggcatcgca 2940
gccgccattg actaccgaag ctacggcact gagaaggcct gctggctgag ggtggataac 3000
tatttcatct ggagcttcat tgggcccgtc tcctttgtta ttgtggtgaa cctggtgttc 3060
ctcatggtga ccctgcacaa gatgatccga agctcatccg tgctcaagcc tgactccagc 3120
cgccttgaca acatcaagtc ctgggcgctg ggtgccattg cactgctctt cctgctgggc 3180
ctcacctggg ctttcggcct cctcttcatc aacaaggagt cagtagtaat ggcttacctc 3240
ttcacaacct tcaacgcctt ccagggggtc ttcatctttg tctttcactg cgccttacag 3300
aaaaaggtgc acaaggagta cagcaagtgc ctgcgtcact cctactgctg cattcgctcc 3360
ccacctgggg gggctcacgg ctcccttaag acctcagcca tgcgaagtaa cacccgctac 3420
tacacaggga cccagagccg aatccggagg atgtggaatg acaccgtgag gaagcagaca 3480
gagtcgtcct ttatggcagg ggacatcaac agcaccccca ccctgaaccg aggtaccatg 3540
gggaaccacc tactgaccaa ccctgtgcta cagccccgtg ggggcactag cccatacaat 3600
acactcattg cagagtctgt gggcttcaat ccctcctcgc ccccagtctt caactcccca 3660
ggaagctaca gggaacctaa gcaccccttg ggcggccggg aagcctgtgg catggacaca 3720
ctgcccctta atggcaactt caacaacagc tactccttgc gaagtggtga tttccctccg 3780
ggggatgggg gtcctgagcc accccgaggc cgaaacctag cggatgctgc ggcctttgag 3840
aagatgatca tctcagagct ggtgcacaac aaccttcggg gggccagtgg gggcgccaaa 3900
ggtcctccac cagagcctcc tgtgccaccc gtgccaggag tcagtgagga cgaggctggt 3960
gggcctgggg gtgctgaccg ggctgagatt gaacttctct acaaggccct ggaggagcca 4020
ctgctgctgc cccgggccca gtcggtgctg taccagagtg atctggatga gtcggagagc 4080
tgtacggcag aggatggggc caccagccgg cccctctcct cccctcccgg ccgggactcc 4140
ctctatgcca gcggggccaa cctgcgggac tcgccctcct acccggacag cagccccgaa 4200
gggcctaatg aggccctgcc ccctccccca cctgctcccc ctgggccccc agaaatctac 4260
tacacctctc gcccgccggc cctggtggct cggaatcccc tacagggcta ctaccaggtg 4320
cggcggccca gccatgaggg ctacctggca gcccccagcc ttgaggggcc agggcccgat 4380
ggggatgggc aaatgcagtt ggtcactagt ctctga 4416
<210> 41
<211> 1473
<212> DNA
<213> Rattus norvegicus
<400> 41
atgaacggag ctttggatca ttccgaccag ccagacccag atgccattaa gatgtttgtc 60
ggacagatcc ctaggtcctg gtcagaaaag gagctgaaag aactttttga gccttatgga 120
gctgtctacc agatcaacgt cctccgggac cggagtcaga accctcccca gagcaaaggt 180
tgttgtttcg taacatttta tacaagaaaa gctgcacttg aggcccagaa tgcactgcac 240
aatattaaaa ctttacctgg gatgcatcat cccattcaga tgaaacctgc agatagtgaa 300
aagtcaaacg ctgtggaaga ccgaaaattg ttcataggaa tggtttccaa gaagtgtaac 360
gagaatgaca tcagagtgat gttttctccc ttcggtcaga tagaagaatg ccggattctc 420
cggggacctg acgggctgag tcgaggctgt gcgtttgtca cattttctac cagggcaatg 480
gcacagaatg caatcaaagc catgcatcag tctcagacca tggagggctg ctcttcacct 540
atcgtggtga agttcgctga cactcagaag gacaaggagc aaaggcgcct ccagcagcag 600
cttgcacagc agatgcaaca gctcaacact gccacttggg ggaacctgac aggactgggt 660
ggacttaccc cacagtacct ggcgcttctg cagcaggcca cctcctccag caacctgggt 720
gcattcagtg gcattcagca aatggctggc atgaatgctt tacagttaca gaatctggca 780
acgctggctg cagctgcagc tgccgcccaa acctcagcca ccagcaccaa tgcaaaccct 840
ctctccagca caagcagtgc cctgggggcc ctcacaagtc ccgtggctgc ttcaaccccc 900
aattctactg ctggtgcagc catgaactcc ttgacctctc ttgggactct gcaaggattg 960
gctggagcca ctgtcggatt gaataatatt aatgcactag cagttgctca aatgctctca 1020
ggtatggcgg ctctgaatgg aggacttggc gccacaggct tgacgaatgg tacggctggc 1080
accatggacg ccctcacgca ggcctactca ggaattcagc agtacgcggc agctgcactg 1140
cccactttgt acagccagag cctgctgcag cagcagagcg ctgcaggcag ccagaaggaa 1200
ggtccagagg gggcaaacct ctttatttac caccttccac aggagtttgg agaccaggac 1260
attctgcaga tgttcatgcc ctttggaaat gttatctctg ctaaagtctt cattgacaaa 1320
cagaccaatc tgagcaagtg ctttggtttt gttagctatg acaatccagt ctctgcacaa 1380
gctgcaatcc aggctatgaa cggctttcag atcggcatga aacgcttgaa ggtgcagctg 1440
aagcgctcca aaaacgacag caaaccttac tga 1473
<210> 42
<211> 1062
<212> DNA
<213> Rattus norvegicus
<400> 42
atggcggcag ccgaggccgc gaactgcatc atggaggttt cctgtggcca agcagaaagt 60
agtgagaagc ccaatgctga ggacatgaca tccaaagact actactttga ctcctatgcc 120
cactttggca tccacgagga gatgctaaag gatgaggtgc gaaccctcac gtaccgcaac 180
tccatgtttc acaatcggca tctcttcaaa gacaaggtgg tgctggatgt gggctcgggc 240
actggcatcc tctgcatgtt cgctgccaag gcaggggccc gcaaggtcat tgggatcgag 300
tgctccagta tctctgatta tgctgtgaag attgtcaaag ccaataagtt agaccacgtg 360
gtgaccatca tcaagggcaa ggtggaggag gtggagctgc ctgtggagaa ggtggacatc 420
atcatcagcg agtggatggg ttattgcctc ttctatgagt ccatgctcaa cactgtgctg 480
cacgctcgtg acaagtggct ggcacctgat ggcctcatct tcccagaccg agccaccctg 540
tatgtgacag ccattgagga ccgacagtat aaagactaca agatccactg gtgggagaat 600
gtatatggct ttgatatgtc ctgcattaaa gacgtggcca tcaaggagcc cctggtggac 660
gtggtggacc caaagcagct ggtcaccaac gcctgcctca taaaggaggt ggacatctac 720
acagtcaagg tggaggacct gaccttcacc tccccgtttt gtctgcaagt gaagaggaat 780
gactatgtgc atgcactagt ggcctacttc aacatcgagt tcacccgatg ccacaagagg 840
accggcttct ctaccagtcc tgagtctcca tacacacatt ggaagcagac tgtgttctac 900
atggaggact acctaacagt gaagaccggc gaggagattt ttggcactat tggaatgagg 960
cccaacgcca aaaacaatcg tgacttggac tttaccatcg acctggactt caagggtcag 1020
ctgtgtgagc tctcttgttc caccgactac cggatgcgct ga 1062
<210> 43
<211> 1395
<212> DNA
<213> Rattus norvegicus
<400> 43
atgctagcag cacggcattt tctcggcggg tcggttcccg tgcgggtatc tgtgcgtctc 60
agcagcggca cgacagcacc caagaaaacc tcatttggct cgctgaagga tgaagaccgg 120
atcttcacca acctgtatgg gcgccatgac tggaggctga agggtgccca gaggcggggt 180
gattggtaca agacaaagga gatcctgctg aaggggcctg actggatctt gggtgaaatg 240
aagacatcgg gtttacgggg ccgtggtggt gctggcttcc ccactggcct caaatggagc 300
tttatgaata agccctcgga tggcaggccc aagtacctgg tggtgaatgc tgacgagggt 360
gagcccggca cctgtaagga ccgagagatc atgcgccatg accctcacaa gctggtggaa 420
ggctgcctgg tgggaggccg ggccatgggg gcccgggctg cctatatcta catccgaggg 480
gaattctaca atgaggcctc caatttgcag gtagctatcc gagaggccta tgaagcaggt 540
ctgattggca aaaatgcctg tgactctgat tatgattttg atgtgtttgt ggtgcgtggg 600
gctggggcct acatctgtgg agaagagact gcgcttattg agtccattga aggcaagcag 660
ggaaagccac gcctgaagcc gccctttcca gcagatgtgg gagtatttgg atgccccaca 720
actgtggcca atgtggagac ggtggctgtg tcccccacca tctgccgtcg tggcggcacc 780
tggtttgctg gctttggccg agaacgcaac tcaggtacca aactgttcaa catctctggc 840
catgtcaacc acccctgcac tgtggaggaa gagatgtctg tgccactcaa agaactgatt 900
gagaaacatg ctggtggtgt cttaggtggc tgggacaacc tccttgctgt gattcctggt 960
ggctcatcca ctccactgat ccccaaatct gtgtgtgaga cagtgctgat ggactttgat 1020
gccctggtgc aggctcagac gggcctgggc acagctgcgg ttattgttat gaacagctcg 1080
acagacattg tgaaagccat cgctcgtctc attgagttct acaagcatga gagctgtggc 1140
cagtgcaccc cgtgccggga gggcgttgat tggatgaaca aggtgatggc ccgatttgtg 1200
aagggggatg cccggccagc tgagatcgac tccctgtggg agatcagcaa gcagatagaa 1260
ggccacacca tttgtgctct gggtgatggg gccgcctggc cagtacaggg tctgatccga 1320
catttccggc ccgagcttga ggatcggatg caacgatttg cccagcagca ccaggccagg 1380
caggcggcct cctga 1395
<210> 44
<211> 921
<212> DNA
<213> Rattus norvegicus
<400> 44
atgacaatgg catatgaaaa cttccagaac ttggggagcg aagagaaaaa ccaagaggct 60
ggtaaagctc ctccccagtc cttcctgtgc aatatcctct cttggaccca cctcctcctg 120
ttctccctgg gccttagcct cctgctgctg gtggttatct ccgtgattgg atcccaaaat 180
tcccagttaa ggagggacct agaaaccctg agaaccactt tagacaacac cacctccaac 240
accaaggctg aactacaggc cctggcctcc aggggtgaca gcttgcaaac aggaatcaat 300
tctctgaaag tggaggtgga tgatcatggg caggaactgc aggcaggccg aggcttgagc 360
cagaaggtgg cttctctgga gagcacagtg gagaagaagg agcagactct cagaacagat 420
ctatctgaaa taaccgatcg tgtgcaacag ctggggaagg acttgaagac cctgacatgt 480
cagctggcca gcctcaagaa caacggctca gcagtggcct gctgccccct tcactggatg 540
gagcatgaag gcagctgcta ctggttctct cagtctggga agccgtggcc tgaagctgac 600
aagtactgcc agctggagaa ttctaaccta gtggtggtca actccctggc ggagcagaat 660
tttctacaga ctcacatggg cagtgtggtc acttggattg gcctaacgga ccaaaatggg 720
ccctggcgat gggtggacgg gaccgactat gagaaaggct ttacgcactg ggccccaaag 780
cagccagata actggtatgg acacgggctg ggaggaggcg aggactgtgc acacttcacc 840
tcagatggtc gctggaatga tgacgtttgc cagaggccct accgctgggt ctgtgagatg 900
aagctggcca aggacagcta g 921
Claims (3)
- 발명의 방법에 따라 검색된 유전자 군은 뇌 부위 중 해마에서 발현된 유전자군을 포함한다.
- 제 1항에 있어서 발현이 유의성 있게 변화된 유전자는 다음과 같다.첫 번째 실험 군에서 유의성 있게 발현 변화를 보인 유전자 군은 'A kinase anchor protein 8 (Rn.10248)', 'Hypothetical LOC288921 (LOC288921), mRNA (Rn.29201)', 'RAP1B, member of RAS oncogene family (Rn.95071)', 'uterine sensitization-associated gene 1 (Rn.2415)', 'insulin-like growth factor binding protein 2 (Rn.6813)', 'protein phosphatase 2A B regulatory subunit delta isoform (Rn.8898)', 'Hypothetical LOC292596 (LOC292596), mRNA (Rn.92802)', 'insulin-like growth factor 2 (Rn.964)', 'transient receptor potential cation channel, subfamily V, member 1 (Rn.3073)', 'ectonucleotide pyrophosphatase/phosphodiesterase 2 (Rn.20403)', 'murine thymoma viral (v-akt) oncogene homolog 2 (Rn.87066)', 'granulin (Rn. 5820)', 'interleukin 15 (Rn.2490)', 'transthyretin (Rn.1404)' 이다.두 번째 실험 군에서 유의성 있게 발현 변화를 보인 유전자 군은 'CUG triplet repeat, RNA-bining protein 2 (Rn.30004)', 'macrophage galactose N-acetyl-galactosamine specific lectin (Rn.779)', 'small inducible cytokine A5 (Rn.8019)', 'CL1BA protein (Rn.10776)', 'heterogeneous nuclear ribonucleoproteins methyltransferase-like 2 (S. cerevisiae) (Rn.5870)', 'Rattus nkinase D-interacting substance of 220 kDa9)' 이다.세 번째 실험 군에서 유의성 있게 발현 변화를 보인 유전자 군은 'neurochondrin (Rn. 5653)', 'kinase D-interacting substance of 220 kDa (Rn. 16792)', 'complement component 1, s subcomponent (Rn. 4037)', 'Rattus norvegicus putative G-protein coupled receptor RA1c mRNA, complete cds (Rn. 12541)', 'Slc38a2: Solute carrier family 38, member 2 (Rn. 16393)', 'mitogen-activated protein kinase 12 (Rn. 42944)', 'sodium channel, voltage-gated, type 1, beta polypeptide (Rn. 4958)', 'nucleophosmin 1 (Rn. 54537)', 'cysteine-sulfinate decarboxylase (Rn. 43232)', 'Add3: Adducin 3, gamma (Rn. 76589)', 'CCAAT/enhancerbinding, protein (C/EBP) delta (Rn. 6975)', 'Protein tyrosine kinase (Rn. 2809)', 'HLA-B-associated transcript 3 (Rn. 22304)', 'interleukin 1 receptor-like 1 (Rn. 10072)', '17-beta hydroxysteroid dehydrogenase type 2 (Rn. 10515)', 'mannosidase, alpha, class 2C, member 1 (Rn. 11301)', 'general transcription factor III C 1 (Rn. 11288)', 'Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor) (Rn. 10148)', 'Albumin (Rn. 34353)', 'Rattus norvegicus retinoblastoma-associated protein mRNA, 3' end (Rn. 55115)', 'zinc finger protein 179 (Rn. 7544)', 'actin alpha cardiac 1 (Rn. 3114)', 'protein phosphatase 2A B regulatory subunit delta isoform (Rn. 8898)', 'Orosomucoid 1 (Rn. 10295)', 'Abcc5a: ATP-binding cassette, sub-family C (CFTR/MRP), member 5a (Rn. 9491)', 'granulin (Rn. 5820)' 이다.
- 제 2항에서 제시된 유전자들의 단백질을 코딩하는 메신져 RNA 서열이다.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020040040139 | 2004-06-02 | ||
| KR20040040139 | 2004-06-02 |
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| Publication Number | Publication Date |
|---|---|
| KR20050115436A true KR20050115436A (ko) | 2005-12-07 |
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| KR1020040052034A KR20050115436A (ko) | 2004-06-02 | 2004-07-05 | 우울증 치료에 사용되는 '반복적 경두개 자기장 법'에 의하여 발현이 변화되는 흰쥐 뇌의 해마 유전자군. |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010115061A2 (en) | 2009-04-01 | 2010-10-07 | Ridge Diagnostics, Inc. | Biomarkers for monitoring treatment of neuropsychiatric diseases |
| US8440418B2 (en) | 2008-11-18 | 2013-05-14 | Ridge Diagnostics, Inc. | Metabolic syndrome and HPA axis biomarkers for major depressive disorder |
| US8450077B2 (en) | 2006-09-05 | 2013-05-28 | Ridge Diagnostics, Inc. | Quantitative diagnostic methods using multiple parameters |
-
2004
- 2004-07-05 KR KR1020040052034A patent/KR20050115436A/ko not_active Application Discontinuation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8450077B2 (en) | 2006-09-05 | 2013-05-28 | Ridge Diagnostics, Inc. | Quantitative diagnostic methods using multiple parameters |
| US8440418B2 (en) | 2008-11-18 | 2013-05-14 | Ridge Diagnostics, Inc. | Metabolic syndrome and HPA axis biomarkers for major depressive disorder |
| WO2010115061A2 (en) | 2009-04-01 | 2010-10-07 | Ridge Diagnostics, Inc. | Biomarkers for monitoring treatment of neuropsychiatric diseases |
| EP2414824A4 (en) * | 2009-04-01 | 2012-09-05 | Ridge Diagnostics Inc | BIOMARKERS FOR MONITORING THE TREATMENT OF NEUROPSYCHIATRIC ILLNESSES |
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