CN107121554A - 治疗神经病理性疼痛的组合物及方法 - Google Patents

治疗神经病理性疼痛的组合物及方法 Download PDF

Info

Publication number
CN107121554A
CN107121554A CN201710216385.9A CN201710216385A CN107121554A CN 107121554 A CN107121554 A CN 107121554A CN 201710216385 A CN201710216385 A CN 201710216385A CN 107121554 A CN107121554 A CN 107121554A
Authority
CN
China
Prior art keywords
sip30
pain
cci
dna
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710216385.9A
Other languages
English (en)
Inventor
于雷
郭宁
张玉秋
赵志奇
景乃禾
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Original Assignee
Rutgers State University of New Jersey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rutgers State University of New Jersey filed Critical Rutgers State University of New Jersey
Publication of CN107121554A publication Critical patent/CN107121554A/zh
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/48—Nerve growth factor [NGF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2842—Pain, e.g. neuropathic pain, psychogenic pain

Abstract

本发明涉及治疗神经病理性疼痛的组合物及方法，具体涉及治疗由SIP30调控的神经病理性疼痛的化合物、组合物、方法、系统和试剂盒。本发明提供了用于治疗神经病理性疼痛的SIP30拮抗剂。

Description

治疗神经病理性疼痛的组合物及方法
本申请是申请号为201080049104.1，申请日为2010年9月2日，发明名称为“治疗神经病理性疼痛的组合物及方法”的中国专利申请的分案申请。
与相关申请的交叉引用
根据《美国法典》第35卷第119节e项(35U.S.C.§119(e))，本申请要求2009年9月2日提交的序列号为61/239,065的美国临时专利申请的优先权，此项申请在此以其全文并入本文作为参考。
关于联邦资助研究的声明
产生本发明的研究是由美国国立卫生研究院基金(NIHGrant R01DA013471)部分支持的。因此，美国政府对本发明拥有一定的权利。
技术领域
本发明涉及在哺乳动物中采用SIP30拮抗剂治疗神经病理性疼痛。
背景技术
神经病理性疼痛是一种复杂的慢性疼痛状态，通常伴有组织损伤。神经病理性疼痛中，神经纤维本身可能是受损的、功能有障碍的或者是损伤的。这些受损的神经纤维将错误的信号发送给其它痛觉中心。神经病理性疼痛的临床病因非常广泛，既包括外伤也包括疾病。例如，大脑或脊髓的外伤性神经压迫或神经挤压和外伤性损伤是神经病理性疼痛的常见病因。此外，大多数外伤性神经损伤还会引起神经瘤的形成，此时，疼痛则是神经异常再生的结果。另外，当肿瘤生长强烈压迫到临近的神经(大脑或脊髓)时便会引发癌症相关性神经病理性疼痛。神经病理性疼痛还和例如糖尿病或酒精中毒等疾病相关。
遗憾的是，目前神经病理性疼痛的的药物治疗方法常常不足以缓解需要此项治疗的患者的疼痛。除此以外，目前的治疗还有严重的副作用，包括，例如认知改变、镇静作用和恶心，在麻醉药物治疗时还会成瘾。很多神经病理性疼痛的患者都是老年人，或者正罹患其它疾病，这尤其限制其对目前药物治疗副作用的耐受力。为数众多的抗炎药、抗焦虑药、麻醉剂，甚至抗惊厥药物都被从业医师用于治疗神经病理性疼痛但是疗效甚微。
目前的缓解神经病理性疼痛的治疗方法的不足急需新的组合物及方法来满足患有这种疾患的病人的生理和社会需求。减轻神经病理性疼痛的方法可以改善那些由外伤或疾病引起的神经病理性疼痛的患者的生活质量。
发明内容
本发明通过提供治疗由SIP30调控的神经病理性疼痛的化合物、组合物、方法和系统满足了前述需求。申请人出人意料地发现，SIP30拮抗剂能有效治疗神经病理性疼痛。本发明还提供了一种筛选方法，所述筛选方法包括以下步骤：提供包含至少部分SIP30多肽的样品；将待测化合物加入到所述样品的至少第一部分中；将来自于样品至少第一部分的至少一个参数与来自于样品至少第二部分的至少一个参数进行比较，其中样品的至少第二部分不包括待测化合物。本申请还包括测定一种物质与SIP30样分子蛋白相互作用的能力，包括以下步骤：a)提供一种SIP30样分子多肽，该多肽包括选自从序列SEQ ID Bl到序列SEQID B130中的任何一种序列的连续氨基酸序列；和b)测定所述物质与SIP30样分子相互作用的能力。
附图说明
图1A和图1B描述了接受慢性压迫性损伤(chronic constriction injury，CCI)手术的大鼠热痛觉过敏和机械性痛觉异常的迅速发生，显示慢性压迫性坐骨神经损伤后机械性痛觉异常(图1A)和热痛觉过敏(图1B)发展的时间进程(和非CCI手术损伤脚爪相比p<0.05)。
图2描述了哺乳动物SIP30直系同源基因氨基酸的序列对比显示高度序列同源性，暗示它们具有相似的功能。对公共数据库中的所有哺乳动物SIP30的氨基酸序列进行了比对，序列比对的间隙显示为空白区。与人类SIP30序列相同的氨基酸残基表示为破折号(-)。下划线代表假定卷曲螺旋结构域。每个物种的普通名、拉丁名和3字母缩写如下：人-Homosapiens–Hsa、黑猩猩-Pan troglodytes—Ptr、恒河猴-Macaca Mulatta—Mml、犬-Canislupus familiaris-Cfa、猪-Sus scrofa-Ssc、牛-Bos taurus-Bta、小鼠-Mus musculus-Mmu和大鼠-Rattus Norvegicus-Rno。
图3A、图3B和图3C描述了SIP30在正常大鼠中的表达模式。(图3A)SIP30在大鼠不同组织表达的Northern印迹分析：两千碱基(kb)大小的SIP30 mRNA用箭头标记，18S核糖体RNA作为上样的内对照；每个泳道RNA的组织来源在图的上部标示(横穿凝胶上部标示)。(图3B)SIP30在背根神经节(dorfsal root ganglion,DRG)的表达。采用抗SIP30抗体(图a)、IB4抗体(图b)和降钙素基因相关肽(CGRP)抗体(图c)进行免疫染色。两两重叠组合图像显示：SIP30和IB4重叠组合图像(图d)、SIP30和CGRP重叠组合图像(图e)以及IB4和CGRP重叠组合图像(图f)。白色箭头标记的是双染色的细胞。(图3C)SIP30在脊髓中的表达：采用抗SIP30抗体(图a)、抗P物质抗体(图b)和抗CGRP抗体(图c)进行免疫染色。重叠组合图像显示如下：SIP30和P物质重叠组合图像(图d)、SIP30和CGRP(图e)以及SIP30、P物质和CGRP三种组分重叠组合图像(图f)。
图4A-图4E显示CCI过程上调了SIP30。(图4A)SIP30 mRNA在脊髓的水平(图上部分)和在DRG(图下部分)的水平。实时PCR扩增结果显示了和正常组动物平均水平相比的SIP30mRNA。收集非手术组(正常组)、假CCI手术组(sham CCI，假手术组)或CCI手术组(分别是术后3天和7天组)大鼠脊髓组织，从假手术组和CCI手术组同侧和对侧分离RNA进行实时PCR分析。CCI术后3天和7天，同侧脊髓都能观察到显著性差异(和正常组或假手术组相比p<0.05)，但在对侧没有观察到显著性差异。DRG没有观察到显著性差异。(图4B)脊髓中SIP30蛋白水平的Western印迹分析。收集假手术组或CCI手术组(术后3天)大鼠的脊髓组织，从假手术组或CCI手术组同侧和对侧分离蛋白进行Western印迹分析。图上部分代表SIP30蛋白的Western带。β-肌动蛋白作为内对照。图下部分是SIP30蛋白的定量结果，脊髓同侧有显著性差异(和假手术组相比p<0.05)。(图4C)DRG中SIP30蛋白水平的Western印迹分析。收集假手术组或CCI手术组大鼠的DRG组织(术后3天)，从假手术组或CCI手术组大鼠的同侧和对侧分离蛋白进行Western印迹分析。图上部分代表SIP30蛋白的Western带。β-肌动蛋白作为内对照。图下部分是SIP30蛋白的定量结果。DRG的同侧和对侧都没有观察到显著性差异。(图4D)CCI术后同侧脊髓背角SIP30蛋白水平增加。图(a)：免疫荧光分析显示正常大鼠(naiverats)中SIP30-IR细胞的本底表达；图(b)和图(b')：免疫荧光分析显示CCI同侧脊髓背角SIP30-IR细胞增加(b,5×；b'10×)；图(c)：SIP30在背角表层(I-II层)和深部(IV-V层)的表达水平定量(用30μm切片中SIP30-IR细胞的数目表示)(与对照组相比，p<0.05，n＝5；ANOVA)。(图4E)SIP30在CCI脊髓的定位。图(a)：CCI手术3天后，SIP30(红色)和NeuN(一种神经元标记物，绿色)在脊髓背角共定位(20×)。图(b)：图(a)框内部分的放大图像的叠加图像(左图)和未叠加的图像(右上图和右下图)(40×)。图(c)：双免疫荧光染色显示，CCI术后3天，SIP30(红色)与GFAP(绿色)在背角没有共染色区域。图(d)：双免疫荧光染色显示，CCI术后3天，SIP30(红色)与(OX-42)(绿色)在背角没有共染色区域。SIP30与GFAP或OX-42的染色没有重叠。
图5A-图5D显示SIP30参与了外周神经损伤诱导的神经病理性疼痛的发展和维持的调节。(图5A)鞘内注射SIP30反义寡核苷酸(AS ODN)4天(从第0天到CCI术后第3天)，CCI同侧脚爪("Ipsi.")因CCI发生的机械性痛觉异常(图a)和热痛觉过敏(图b)得以减少(和NS或MM组相比p<0.05)，而NS和MM ODN没有效果。同样处理后(图c，d)，对侧脚爪("Cont.")没有任何变化。(图5B)鞘内注射第二种SIP30 AS ODN(SIP30 ASII,靶向SIP30基因编码区第143-162位核苷酸)4天后(从第0天到CCI术后第3天)，机械性痛觉异常(图a)和热痛觉过敏(图b)在CCI同侧脚爪减轻(和RD组相比p<0.05，p<0.01)，而随机寡核苷酸(RD ODN)没有效果。同样处理后(图c，d)，对侧脚爪没有变化。(图5C)产生机械性痛觉异常和热痛觉过敏后，鞘内注射SIP30 AS ODN 4天(从CCI术后第3天到第7天)能显著抑制CCI同侧脚爪的机械性痛觉异常和热痛觉过敏(和NS组或MM组相比，p<0.05)，而NS组和MM ODN组则没有效果。同样处理后(图c，d)，对侧脚爪没有变化。(图5D)在正常大鼠(naive rats)鞘内注射SIP30 ASODN 4天对于双侧脚爪对Von Frey刺激(图a)或热刺激(图b)的基础反应都没有影响。
图6A-图6D显示用抗-SIP30的反义寡核苷酸敲降SIP30和SNAP25水平。(图6A)CCI术后SIP30 mRNA增加，这种增加可以被反义寡核苷酸(ODN)削弱。鞘内注射SIP30反义寡核苷酸(AS)或错义(MM)ODN 4次后，最后一次注射6小时后，处死大鼠切下腰髓。实时PCR扩增显示，接受SIP30 AS ODN的CCI大鼠和接受MM ODN的CCI大鼠相比同侧脊髓SIP30 mRNA显著降低(p<0.05)。虚线显示假CCI手术组大鼠的mRNA水平。(图6B)Western印迹显示，接受SIP30 AS ODN的CCI大鼠和接受MM ODN或NS的CCI大鼠相比，同侧脊髓SIP30蛋白显著降低。图上部分表示SIP30蛋白的Western带。β-肌动蛋白作为内对照。图下部分是SIP30蛋白定量结果。虚线显示假手术组的蛋白水平。(AS组，感觉这里应该说*是指AS组与NS或MM组相比差异显著)和NS组或MM组相比有显著性差异(p<0.05)。缩略语：NS，生理盐水；AS ODN,反义寡核苷酸；MM，错义；0-3天，大鼠从第0天(CCI术前6小时)到CCI术后第3天鞘内注射AS、MM或NS；4-7天，大鼠从CCI术后第4天开始到CCI术后第7天鞘内注射AS、MM或NS。(图6C)实时PCR扩增显示SNAP25mRNA在CCI术后同侧脊髓显著升高(和假手术组相比p<0.05)。鞘内注射SIP30 AS ODN(每24小时一次×4次)导致CCI大鼠同侧脊髓SNAP25mRNA有降低的趋势(虽然没有达到统计学显著性差异)。(图6D)实时PCR扩增显示CCI术后同侧脊髓PSD95mRNA显著升高(和假手术组相比p<0.05)。鞘内注射SIP30 AS ODN(每24小时一次×4次)对PSD95mRNA水平没有影响。
图7显示，和对照组小鼠相比，在试验的第4、6和8天，A组和B组SIP30小鼠脚爪回缩阈值和对照组相比显著改变(*表示和对照组相比有显著性差异，p<0.05，).
具体实施方式
为了有助于理解本发明，提供了以下非限制性的定义：
术语"痛觉异常"是指对通常的非痛觉刺激的疼痛反应，可以是静态的，也可以是机械性的。"痛觉异常"的病理生理学被认为不同于提及的疼痛，但可能发生在刺激区域之外。
术语“基因”是指包含生产多肽或其前体所必需的包括控制序列及编码序列的DNA序列。所述多肽可以由完整长度的编码序列(可以是基因组DNA或cDNA)编码或由能保留预期活性的编码序列的任何部分编码。在某些方面，术语“基因”还指能编码所述多肽或其前体的mRNA序列或其一部分。
术语“转染”是指细胞对外源DNA的摄取。当外源(异体)DNA被引入细胞膜内时细胞被“转染”。转染可以是瞬时的(即引入的DNA停留在染色体之外并在细胞分裂时被稀释)或稳定的(即引入的DNA整合到细胞基因组中或维持为稳定的染色体外单元)。
术语“共转染”指两个或更多的载体同时或顺序进入某一个细胞。
术语“启动子元件”或“启动子”是指能与细胞中的RNA聚合酶结合(例如，直接结合或通过其他启动子结合蛋白或启动子结合物质结合)并启动编码序列转录的DNA调控区。通常，启动子序列的3’末端由转录起始位点界定，然后向上游延伸(5’方向)以包括在任何水平启动转录必需的最少数量的碱基或元件。在启动子序列中可能会发现转录起始位点(例如，可用核酶S1图谱来方便确定)以及负责结合RNA聚合酶的蛋白质结合区(一致序列)。启动子可以可操作地与其他表达调控序列(包括增强子或抑制子)结合。
术语“可操作地结合”，“以可操作的顺序”或“可操作地连接”是指该核酸序列的连接方式使得能指导某一特定基因转录和/或某一目标蛋白合成的核酸分子能够产生。该术语还指氨基酸序列以能产生功能蛋白的方式连接。
术语“载体”是指能将基因序列转移到靶细胞中的核酸组装体(如病毒载体、非病毒载体、微粒载体和脂质体)。术语“表达载体”是指含有能指导目的序列或基因在细胞中表达的启动子的核酸组装体。载体通常含有编码选择标记物的核酸序列，以选择那些被载体转染的细胞。通常，“载体构建”、“表达载体”和“基因转移载体”是指任何能指导目的基因表达并能将基因序列转移到靶细胞的核酸构建体。因此，该术语除了包括病毒载体还包括克隆和表达载体。
术语“抗体”是指完整的抗体(包括多克隆抗体和单克隆抗体)或其片段(例如，F(ab)2、Fab、FV、VH或VK片段、单链抗体、多亚基单特异性抗体或其片段、双特异性/多异性抗体或其片段。该术语还包括人源化抗体和嵌和抗体。
术语“SIP30”是指编码一个与266个氨基酸的与SNAP25蛋白质相互作用的30kDa的蛋白质的核酸序列。SIP30在神经组织中表达非常丰富，在睾丸和肾也有少量表达。术语“SIP30相关”是指从序列SEQ ID Al到序列SEQ ID A130所列的任何核酸序列。
术语“SIP30拮抗剂”是指任何单独或联合作用能阻止、抑制、减少或中和SIP30的表达或其活性，直接或间接调控诱导神经病理性疼痛的中间体神经垂体素II(“NPII”)活性的物质、化合物和组合物，合成的或天然的，包括但不限于反义核酸序列、siRNA、抗体和小分子实体。
术语“SNAREs”是指一种类型的NPII，它是可溶性N-乙基马来酰亚胺-敏感因子附着蛋白受体，对于神经传递中突触小泡的胞吐作用的调控起着关键作用，包括但不限于25kDa的突触相关蛋白(SNAP25)、突触融合蛋白、突触小泡-相关膜蛋白(VAMP)。
术语“治疗”疾病或疾病的“治疗”是指实施一种方案，该方案可以包括给人类或其他患者使用一种或多种药物，以期减弱该疾病的症状或体征。减弱可以发生在疾病的症状或体征出现之后也可以发生在疾病的症状或体征出现之前。因此，“治疗”疾病或疾病的“治疗”包括“预防”疾病或疾病的“预防”，“治疗”疾病或疾病的“治疗”不需要完全消除症状或体征，不需要治愈，并且特别地包括对患者只有微小效果的方案。
术语“患者”是指可以对其进行治疗的生物系统。该生物系统可能包括例如单个细胞、一组细胞(如细胞培养物)、器官、组织或多细胞生命体。患者可以指人类患者或非人类患者。
术语“痛觉过敏”是指对疼痛敏感性增加，可能是由于伤害性感受器或外周神经的损伤引起。
本发明旨在提供治疗由SIP30调控的神经病理性疼痛的化合物、组合物、方法和系统。申请人出人意料地发现SIP30拮抗剂可以有效治疗神经病理性疼痛。申请人发现SIP30拮抗剂，包括但不限于核苷酸、小干扰RNA(siRNA)分子、与至少部分SIP30核酸序列反应的天然的或人工合成的化合物，能直接或间接通过调节NPII活性有效抑制SIP30表达从而提供了一种治疗SIP30引起的疼痛的方法。
本发明另一方面，提供能改变SIP30依赖性中间体蛋白的构象从而拮抗SIP30表达的小分子。在本发明的另一个实施方式中，拮抗剂的效果可以通过具有特异性底物结合位点(该位点与一个或多个靶核酸区域或靶RNA的一部分互补(即可形成碱基对))的siRNA来实现。优选地，这种互补是100％，然而如果需要，这种互补可以更低，诸如可以是91％、92％、93％、94％、95％、96％、97％、98％或99％。
因此，本发明的一个方面提供了DNA片段、多肽、化合物及其组合物在患病区拮抗SIP30表达和/或活性的用途。本发明的另一方面在于提供能拮抗NPII活性的人工合成的或天然的化合物。而本发明的另外一个方面旨在提供将适合的分子递送到引发神经病理性疼痛的目标区域的植入储库。
本发明的至少一个方面旨在提供与至少部分诱导神经病理性疼痛的核酸序列反应的、能抑制NPII或任何诱导相关的疼痛的细胞因子在细胞中表达的核酸分子。
本发明的另一方面在于使得本领域的普通技术人员应用设计的分子实体、组合物和/或其他能通过抑制、中和或减少SIP30在神经病理性疼痛发作中的级联作用从而减弱神经病理性疼痛的治疗方式。
本发明的另一方面，发明人提出了治疗神经病理性疼痛的治疗方法，所述神经病理性疼痛包括脊髓介导的疼痛、外周神经损伤相关的疼痛、椎间盘脱出相关疼痛、腕管综合征(Carpel tunnel syndrome)、多发性硬化症、纤维肌痛、带状疱疹、HIV-相关神经病理性疼痛、疼痛性创伤性单神经病变、疼痛性多神经病变(尤其是糖尿病引起的)、中枢疼痛综合征(可能由神经系统的任何水平的病灶引起)、术后疼痛综合征(如乳腺切除术后综合征、开胸手术后综合症和幻觉痛),以及复杂的区域性疼痛综合征(反射性交感神经萎缩症和灼性神经痛)。
本发明的另一方面是提供一种表达载体，该表达载体包含至少一个编码与至少部分SIP30核酸序列反应的、能抑制疼痛介质在细胞中表达的siRNA分子的DNA序列，该DNA序列可操作地连接到能指导所述siRNA分子在宿主细胞中表达的遗传控制元件。
本发明的另一方面是提供一种治疗患有神经病理性疼痛的机体的方法，该方法包括给所述机体施用选自以下一组化合物中的至少一种化合物：与SIP30核酸序列和/或SIP30蛋白的至少一部分反应并能拮抗其活性的反义序列、siRNA分子、多肽和小分子。
本发明的另一方面旨在提供一种治疗患有神经病理性疼痛的患者的系统，该系统包括至少一种反义或siRNA分子、多肽或小分子，可以单独使用或联合使用，或进一步与其他神经病理性疼痛治疗方法或形式合用，以及最终将所述化合物导入患者靶组织的工具。
本发明的另一方面提供了候选化合物，包括与SIP30核酸序列的至少一部分反应并能通过注射、泵或储库导入靶组织的反义序列、siRNA分子。
本发明的在应用时，可以在机体靶位点或其附近植入储库植入物。这些位点的非限制性的例子包括发炎的神经、大脑或脊髓中受压迫的神经位点或其周围的软组织。
在本发明的另一实施方式中，在患病位置放置了siRNA储库植入物。在本发明的其它实施方式中，可在患者的肩部、髋部、其它关节或脊柱中放置药物储库植入物。
在一种实施方式中，为了方便起见，采用导管作为一种或多种SIP30拮抗剂分子的靶向给药系统。在另一种实施方式中，采用注射针管作为靶向给药系统。
本发明的一个方法中，靶向给药系统包括：药物储库植入系统通过在靶位点或其附近插入导管局部给药，所述导管具有一个近端和一个远端，所述的远端具有用于SIP30拮抗剂原位递送给药的开口，所述近端通过液体连接到药物给药泵。例如，所述导管的近端可以在靶位点10厘米范围内用于分子给药，尤其是可以在靶位点5厘米范围内给药。
本发明的药物储库植入物的一种实施方式中，SIP30拮抗剂可抑制由TNF-α、IL-1、IL-6和其他诱导疼痛的细胞因子介导的其他疼痛介质。
在本发明的一种实施方式中，适合的化合物还进一步包括改变释放途径的药物组合物。该系统可以进一步包括两种或更多的分子组合。在另一种实施方式中，采用导管而不是储库。在这种实施方式中，所述导管具有一个近端和一个远端，所述的远端具有用于SIP30拮抗剂原位给药的开口，所述近端通过液体连接到药物给药泵。
为了更好理解本发明的原理，在最优选的实施方式中使用了参考文献和特定的语言进行描述。然而不能因此理解为意欲限制本发明的范围，这些变化和本发明进一步的改进，以及本发明所描述的原理的其它应用，对于本发明相关技术领域普通技术人员来讲都当理解为正常的。
本发明特别指向了治疗疼痛的组合物和方法，这是源于发明人发现抑制SIP30能减轻神经病理性疼痛。在某些优选的实施方式中，SIP30拮抗剂或相关分子可对在中央或局部引发神经病理性疼痛的神经直接给药，或其附近的组织位点给药。
基于本发明，本领域的技术人员可以推导出，能抑制SIP30的分子可以造成神经病理性疼痛痛觉的减弱。因此，本发明的疼痛治疗适用于神经病理性疼痛，包括脊髓介导的疼痛、压迫性损伤、外周神经损伤相关的疼痛、椎间盘脱出相关疼痛、腕管综合征(Carpeltunnel syndrome)、多发性硬化症、纤维肌痛、带状疱疹、HIV-相关神经病理性疼痛、疼痛性创伤性单神经病变、疼痛性多神经病变(尤其是糖尿病引起的)、中枢疼痛综合征(可能由神经系统的任何水平的病灶引起)、术后疼痛综合征(如乳腺切除术后综合征、开胸手术后综合症和幻觉痛),以及复杂的区域性疼痛综合征(反射性交感神经萎缩症和灼性神经痛)。在某些实施方式中，拮抗SIP30或其相关分子的物质可以直接向神经或在神经附近的组织处给药。
本发明通过以下非限制性的实施例进行更充分描述。所引用的所有参考文献在此以其全文并入本文作为参考。以下实施例中的数据显示，SIP30是神经病理性疼痛发展和维持的分子组分，用反义寡核苷酸拮抗SIP30可缓解神经病理性疼痛慢性压迫性损伤(CCI)大鼠模型的疼痛。发明人还表明，哺乳动物SIP30序列是高度相关的。因此，本发明提供了通过拮抗SIP30治疗任何种类的哺乳动物神经病理性疼痛的组合物和方法。基于本发明，本领域的技术人员可以很容易地推导出，任何已知的拮抗方法(包括用诸如寡核苷酸拮抗SIP30mRNA的产生、或用化合物和/或抗体拮抗SIP30蛋白)都能产生本发明公开的缓解疼痛的效果。
另外，本领域技术人员可以很容易地推导出可以通过拮抗与SIP30相关的分子来缓解神经病理性疼痛；这样的分子可以是突触小泡相关蛋白，和/或通常称作SNAREs的分子(Ungar和Hughson,2003；Brunger,2005)。
本发明提供了一种能减轻疼痛的有利策略，所述疼痛是任何与能诱导或表达SIP30蛋白任何部分的医学状态相关或由能诱导或表达SIP30蛋白任何部分的过程引起的疼痛。SIP30在某些哺乳动物组织中很丰富。在大脑中，SIP30在上丘脑和下丘脑高度表达，上丘脑和下丘脑包含着重要的听觉和视觉系统的中继核。GST沉降试验和免疫沉淀实验表明，SIP30与SNAP25直接结合。虽然在GST-pull-down实验中SIP30不直接与突触融合蛋白直接发生相互作用，突触融合蛋白确实与SIP30发生免疫共沉淀，这表明突触融合蛋白可能是通过SNAP25间接与SIP30相关联。
本发明的发明人通过实施例公开了减轻与外周神经损伤相关的神经病理性疼痛的化合物和方法。
在本发明的至少一个方面，SIP30拮抗剂局部给药能防止、降低或至少减少了系统给药的主要副作用。在至少一个实施方式中，使用低剂量的SIP30拮抗剂分子局部给药可获得目标靶位点SIP30拮抗剂的高浓度，减轻了系统副作用的风险。
另外，本发明的另一方面还包括通过将SIP30拮抗剂单独或与其他适合的药物一起结合到可局部或中枢释放该药物的生物可降解储库植入物，以实现药物缓释以长期缓解神经病理性疼痛，所述的其他适合的药物选自抗惊厥剂、抗炎药、靶向不同离子通道的化合物、阿片类物质、钠通道阻断剂、抗抑郁药或麻醉剂，更具体地说，包括但不限于美西律、利多卡因、反胺苯环醇、吗啡、阿芬他尼、克他命、甲基强的松、腺苷、甘氨酸拮抗剂、地昔帕明、文拉法辛和加巴喷丁。
另一方面，本发明采用能与SNAREs的至少部分SIP30细胞因子核酸序列对应的反义分子或siRNA分子，提供了抑制NPII或抑制诱导神经病理性疼痛的细胞因子在细胞中表达试剂、方法和系统。申请人发现靶向NPII和相关细胞因子mRNA的SIP30拮抗剂能有效抑制诱导神经病理性疼痛的细胞因子的表达，从而提供了在机体中治疗疼痛的改进的方法。一方面，本发明的方法可以采用分子生物学常规技术来实现。公开了一般分子生物学方法的基础教科书包括《分子克隆实验手册》(2001年第3版)(Sambrook等)、《现代分子生物学技术》(1994)(Ausubel等)。与本发明相关的更专业的教科书包括《RNA干扰导致基因沉默，技术与应用》(2004)(Sohail)。
本发明的一个大方面涉及一种分离的核酸分子，所述核酸分子含有编码与SNAP25相互作用蛋白编码区第11-31位核苷酸互补的核酸序列(GenBank登录号为BC063144)。具体而言，所述分离的核酸分子编码的蛋白质能中和与相关神经病理性疼痛现象相关的SIP30的上调。另外，本发明还旨在提供包含这些核酸分子的载体，以及含有所述载体的宿主细胞。另一方面，具体而言，本发明涉及所述蛋白质本身。
本发明第二个大方面涉及SIP30蛋白和SNAREs(包括大鼠SNAP和如图2所示的所有哺乳动物SIP30的同源的或同源类似物的序列)的特异性抗体。在本发明的一个具体方面，所述的抗体是多克隆抗体。在本发明另一个具体方面，所述的抗体是单克隆抗体。
本发明的第三大方面涉及在产生特异性神经病理性疼痛的组织(例如，脊髓同侧)局部降低SIP30上调或中枢性降低SIP30上调的方法。在一个具体方面，分离的核酸分子在载体内，该载体可以是质粒或病毒(如腺病毒或逆转录病毒)。转染可以发生在体外或通过直接注射分离的核酸分子发生在体内。在一个替代的途径中，SIP30拮抗剂的直接给药也是可能的。
在本发明另一个大方面，发明人发现了一种测定适合的SIP30拮抗剂与SIP30样分子蛋白(包括SNAREs)相互作用能力的方法，该方法包括：a)提供一种SIP30样分子多肽，该多肽包括选自从序列SEQ ID Bl到序列SEQ ID B130的任何一种序列的连续的氨基酸序列；和b)测定所述物质与SIP30样分子相互作用的能力。在本发明更具体的一个实施方式中，测定所述物质与SIP30样分子相互作用能力的步骤包括测定所述物质与SIP30样分子的相互作用亲和性。
在另一种实施方式中，发明人公开了一种测定一种物质与SIP30样分子相互作用能力的方法，该方法包括：a)提供一种重组SIP30样分子多肽，该多肽由包括选自从序列SEQID Al到序列SEQ ID A130的任一序列的至少35个连续的核苷酸序列编码；b)使所述物质与所述重组SIP30样分子多肽接触；和c)测定所述物质与所述重组SIP30样分子结合的能力。在本发明更具体的一个实施方式中，所述核酸序列包括选自从序列SEQ ID Al到序列SEQID A130的任一序列的至少45个连续的核苷酸。在本发明另一个更具体的实施方式中，所述核酸序列包括选自从序列SEQ ID Al到序列SEQ ID A130的任一序列的至少50个、75个或100个连续的核苷酸。
本发明的一个方面旨在提供测定适合的SIP30拮抗剂与SNAREs和SIP30样分子多肽相互作用能力的方法，该方法包括测定：a)所述重组SIP30样分子多肽与所述物质相互作用的能力；b)所述物质激活细胞膜离子通道的能力；或c)调节b)部分细胞膜离子通道的能力，具体而言，其中所述重组SIP30样分子多肽是嵌合体。
本发明的另一方面旨在提供测定一种物质与SIP30样分子结合能力的方法，该方法包括：a)在细胞中表达由包括选自从序列SEQ ID Al到序列SEQ ID A130的任一序列的至少25个连续碱基的核酸序列编码的重组SIP30多肽；b)使所述物质与所述重组SIP30样分子多肽接触；和c)测定所述物质与所述重组SIP30样分子结合的能力。在本发明这一方面，所述核酸序列包括选自从序列SEQ ID Al到序列SEQ ID A130的任一序列的至少45个连续的核苷酸。在本发明另一个更具体的实施方式中，所述核酸序列包括选自从SEQ ID Al到SEQID A130的任一序列的至少40个、45个、50个、75个或100个连续的核苷酸。
本发明一个优选的实施方式提供了与大鼠SIP30编码区的11031核苷酸互补的反义寡脱氧核苷酸。本发明另一方面旨在提供能与至少部分SIP30核酸序列相匹配的siRNA分子、编码SNAREs的mRNA(包括能抑制细胞中所述造成神经病理现象的蛋白或细胞因子表达的SNAP25)。
本发明的siRNA通常都是短的(19-29个核苷酸)、双链RNA分子，能使互补靶mRNA产生序列特异性降解(即RNA干扰，RNAi)(Bass,Nature 411:428(2001))。因此，在某些实施方式中，siRNA分子包含一个双链结构，该双链结构包含一个正义链和一个反义链，其中所述的反义链包含一段核苷酸序列，该核酸序列与多肽、蛋白质或细胞因子至少部分核苷酸序列互补；正义链包括一段核苷酸序列，所述核苷酸序列与所述反义链的核酸序列的至少一部分互补；其中每条正义链和反义链都包含大约19-29个核苷酸。
靶向NPII或疼痛-诱导细胞因子或蛋白的siRNA分子可以基于本领域众所周知的准则进行设计(如Elbashir等,EMBO J.20:6877(2001))。例如，靶mRNA的靶标部分优选以AA(最优选)、TA、GA或CA开始；siRNA分子的GC比优选为45-55％；siRNA分子在一行中优选不含有3个连续相同的核苷酸；siRNA分子在一行中优选不含有7个混杂的G/C；siRNA分子优选在每个3’末端都含有二核苷酸突出(优选TT)；靶标部分优选位于靶mRNA的ORF(开放性阅读框)区，位于起始密码子ATG之后至少75个碱基对，且在终止密码子之前至少75个碱基对；靶标部分优选不含有16-17个连续的与其他编码序列同源的碱基对。基于以上部分或全部准则可以确定优选的疼痛-诱导细胞因子siRNA靶序列。
因此，本发明另一方面提供一种抑制SIP30疼痛-诱导蛋白或细胞因子或其他介质在细胞中表达的方法，该方法包括在细胞中引入至少一个能与疼痛-诱导核酸序列的至少一部分反应的反义分子或siRNA分子。虽然任何细胞都可以作为靶标，但是，引入所述分子的细胞优选是SIP30有上调风险的中枢神经系统区域，更优选为脊髓，或者有疼痛诱导蛋白或细胞因子存在的局部区域。在更优选的实施方式中，所述区域来自遭遇损伤的机体，优选人类患者。
本发明的化合物和分子可以采用本领域众所周知的技术在体外或体内引入细胞内，包括电击、钙磷共沉积、微注射、脂质体转染、多转染和与细胞穿透肽(CPP)偶联。
可替代地，这些靶向诱导疼痛的细胞因子的分子可以在体内通过编码正义序列和反义序列的表达载体内源产生而引入细胞内。
遗传控制元件包括转录启动子，还可以包括转录增强子以增加mRNA表达水平，编码适合的核糖体结合位点的序列，以及终止转录的序列。适合的真核启动子包括组成型RNA聚合酶II启动子(如巨细胞病毒(CMV)启动子、SV40早期启动子区域、包含Rous肉瘤病毒(RSV)3'长末端重复序列的启动子、单纯疱疹病毒胸苷激酶(TK)启动子和鸡β-肌动蛋白启动子)，组织特异性RNA聚合酶II启动子和RNA聚合酶III启动子(如U6、HI、7SK和7SL启动子)。
在一些实施方式中，正义链和反义链可以由不同的表达载体编码(即共转染的载体)。在另一些实施方式中，siRNA分子的正义链和反义链由相同的表达载体编码。采用收敛转录或背离式转录(convergent or divergent transcription)，正义链和反义链可以独立地由单一的表达载体表达。
可替代地，正义链和反义链可以由一个单独的表达载体以单个发卡RNA分子的形式共同表达，既可以表达成短发卡RNA(shRNA)分子形式(如Arts等,Genome Res.13:2325(2003))，也可以表达成长发卡RNA分子形式(如Paddison等,Proc.Natl.Acad.Sci.USA 99:1443
(2002))。
诱导神经病理性疼痛的中间体、细胞因子多肽(或其片段)可以采用众所周知的多种免疫方法检测和定量，诸如酶联免疫法(ELISA)、放射免疫法(RIA)、免疫沉淀法、免疫荧光法和Western印迹。免疫方法中所用的抗前炎性细胞因子抗体(优选抗人前炎性细胞因子抗体)可以从商业渠道获得，如EMD Biosciences(San Diego,CA),Upstate(Charlottes-ville,VA),Abcam(Cambridge,MA),Affinity Bioreagents(Golden,CO)and NovusBiologicals(Littleton,CO),或可以由本领域熟练技术人员按众所周知的技术制得。
本发明的另一方面，提供了一种筛选方法，该方法包括以下步骤：提供一种含有至少部分SIP30和/或SIP30蛋白的样品；向所述样品中的至少第一部分中加入待测化合物；将来自于至少样品第一部分的参数与来自于至少样品第二部分的一个参数进行比较，其中至少样品的第二部分不包括待测化合物。
来自于至少样品第一部分的至少一个参数和来自于至少样品第二部分的至少一个参数的差别的大小是待测化合物的指标，尤其是它改变SIP30表达和活性的能力，或上调SIP30的能力。
本发明的另一方面提供了试剂盒，包括至少部分SIP30和/或至少部分SIP30蛋白和至少一定量的对照化合物。
本发明的另一方面提供了一种评估机体在术后发生神经病理性疼痛的风险的方法，包括测定SIP30基因产物在机体样品中的量；然后将测定量和对照样品中SIP30基因产物的标准量进行比较，如果发现测定量在SIP30基因产物的标准范围之外即为诊断术后神经病理性疼痛风险的阳性指征。
反义或siRNA分子单独使用或与其他解痉剂、抗炎药、麻醉剂联合使用来抑制诱导神经病理性疼痛细胞因子的表达可作为在机体治疗炎症反应的用途或方法。因此，本发明另一方面提供了一种治疗神经病理性疼痛患者的方法，包括给所述患者引入至少有效量的能与至少部分SIP30核酸序列反应的SIP30拮抗剂。所述治疗炎症的方法可以采用将所述分子向目标组织靶向给药的系统实现。因此，本发明的另一方面提供了将有效量的所述药剂引入患者的组织的方法。在优选地实施方式中，所述的患者是人类。
关于组织的基因递送给药，存在着大量的众所周知的方法，诸如，以导管、注射针管或储库植入物为例。优选的给药系统包括储库植入物。本发明的储库植入物包括有助于在患者的靶位置植入和保留的物理结构。药物储库植入物可以包括微球，微球还可以进一步包括分离的核酸、能给机体靶向提供浓度梯度的药物的siRNA分子。在本发明的另一个实施方式中，微球是注射到靶组织的。
本发明的另一方面，本领域的普通技术人员可以理解，速释制剂或缓释制剂形式存在的产品的不同组合都适合本发明。例如，实施者可以将至少一种SIP30拮抗剂和载有至少一种解痉剂、抗抑郁剂、抗炎剂、阿片类物质或麻醉剂的凝胶和微球一起制成制剂，其中凝胶和微球的组合被置于靶标区域。本发明实施时，可以局部给药或持续给药。
本发明的试剂、方法和系统也都可以用于机体的多种器官。
根据本发明的方法,具体实施方式将用以下的实施例进行描述。虽然本发明采用了具体的实施方式进行描述，这些实施方式应该理解为仅仅是为了形象描述本发明的原理和应用。因此应当理解，这些描述性的实施方式可以进行大量的变化，而其他的安排涉及也不会背离由以下权利要求所定义的本发明的精神和范围。
实施例
实施例1：拮抗SIP30以抑制周围神经损伤诱导的神经病理性疼痛的发展和持续
材料和方法
实验动物：成年雄性Sprague-Dawley大鼠，200-280克，每笼2只，自由饮食，12:12小时明暗周期，室温恒定。
鞘内植管。戊巴比妥钠(40mg/kg,腹腔注射)麻醉下，鞘内导管(PE-10导管)通过L4和L5腰椎之间的间隙插入，深入到腰椎膨大的硬膜外腔(L4和L5部分)。导管用无菌生理盐水充满(大约4μl)，外末端塞住。插了导管的大鼠恢复4天，单独饲养。任何表现因手术过程而发生神经性缺陷的大鼠都被剔除出本实验。
坐骨神经的慢性压迫性损伤模型(CCI)。大鼠用戊巴比妥钠((45mg/kg,腹腔注射)深度麻醉，右侧坐骨神经用钝解剖钳暴露在大腿中部。CCI手术组：根据Bennett和Xie(1988)的描述，坐骨神经在其三叉分支的近端用4道铬制肠线(4-0)松弛结扎，彼此相距大约1毫米；假手术组：坐骨神经暴露但不结扎。CCI或假手术后，用4-0丝线分别分层缝合肌肉和皮肤，用抗生素粉抗感染。
反义寡核苷酸(ODN)的制备和给药。反义序列(AS,5'-TTT CTC CGC GTC CGC CATGGT-3')SEQ.ID No.B131，与大鼠SNAP25相互作用蛋白30(SIP30,GenBank登录号BC063144)编码区的11-31位核苷酸互补，以及其相应的错配序列SEQ.ID.No.B132(MM,5'-TTT CCTCGC GTC CCG CAT GGT-3')都为Integrated DNA Technologies公司(Coralville,IA,USA)合成和纯化。
所有的ODN都是采用BLAST算法在GenBank数据库中筛查以排除反义ODN的非特异性结合，并表明错义ODN不与登记的核苷酸序列匹配。ODN在给药前重溶于0.9％的生理盐水(NS)中。大鼠分别鞘内注射NS(10μl),AS(50μg/10μl)和MM(50μg/10μl)，然后用5μl生理盐水冲洗，每24小时冲洗一次，共冲洗4天(给药方案I：从第0天(CCI术前6小时)到CCI术后第3天；给药方案II：从CCI术后第4天到第7天)。
RNA提取和实时PCR分析。在CCI或假手术术后第3天或第7天处死大鼠。为了评价神经病理性疼痛的发展情况和反义治疗的效果，处死前，按如2.6所述的方法检测大鼠的机械性痛觉异常和热痛觉过敏。来自正常组大鼠、假手术组大鼠和CCI组大鼠的脊髓用AS、MM或NS处理，然后切成两部分，即CCI同侧和CCI对侧。对同样处理的大鼠的DRG(L4-L6)进行解剖。收集两组大鼠同侧和对侧DRG单个样品。
切开后，所有组织迅速在干冰中冷冻并储存于-80℃直到进一步处理。冷冻的脊髓直接用1ml TRIZOL试剂(Invitrogen,Life Technologies,Carlsbad,CA,USA)均质化。根据厂家的操作规程略有修改进行总RNA的提取。简单地说，氯仿提取之后，RNA用异丙醇沉淀，沉淀用70％乙醇冲洗两次。在空气中干燥，而后RNA用超纯水重悬。总RNA的质量和数量用电泳法以及A260测定(Agilent 2001Bioanalyzer,Palo Alto,CA)检测。提取的RNA用DNase I(不含DNA,Ambion)处理以去除基因组DNA。cDNA用随机十聚体引物采用AmbionRETROscript反转录试剂盒根据厂家的操作说明合成。用不含RNA的阴性对照反应来检测试剂是否污染。
实时PCR。在Cepheid Smart Cycler上进行实时PCR分析。循环阈值(Ct)采用SmartCycler Data Analysis Software 2.0(Cepheid)进行计算。PCR反应采用LightCycler DNAMaster SYBR Green I kit在20μl的终体积中进行，包括：12.6μl PCR级水,2.4μl MgCl2(25mM)，2μl 10x LightCycler DNA Master SYBR Green I[Taq DNA聚合酶，反应缓冲液dNTP混合物(用dUTP 代替dTTP)，SYBR Green I染料，和10mM MgCl2]，2μl cDNA模板，0.5μl正向和反向引物(100ng/μl)。
扩增方案包括95℃，150秒激活Taq DNA聚合酶；然后40个循环(95℃,10秒变性；58℃，15秒退火和72℃，20秒延伸)。在所有情况下，首先可以观察到样品cDNA的量和Ct的线性关系。每个样品都运行3遍，Ct值取每次反应的平均值。
关于对照，运行无模板的对照，以水代替模板。RT-PCR分析的结果用Ct值表示，用来确定靶基因mRNA相对于参照基因mRNA量的量。在本研究中，采用β-肌动蛋白作为参考基因标准化表达水平。相对基因表达水平用靶基因和β-肌动蛋白基因表达量按照以下公式计算：(Livak和Schmittgen，2001；Marvizon等，2002；Beltramo等，2003):mRNA相对表达＝2-(靶基因Ct-β-肌动蛋白Ct)。引物用Invitrogen Custom Primer Designer软件设计.
测定机械敏感性的Von Frey纤维试验。后爪回缩阈值采用von Frey纤维(Stoelting,IL,USA)校正系列确定(范围是0.6到18克)。动物各自置于底部带有网眼的电线笼中，适应30分钟。将von Frey纤维系列应用于足底表面中央区，对左后爪施加不断增加的力(0.6,0.9,1.3,2.2,4.8,6,7.2,9,13和18克)，每单次试验时间达6秒。只有大鼠静止并四爪着地时才施用von Frey纤维。只有当后爪完全从带网眼的底部离开时才认为回缩反应是真实有效的。回缩反应成立时，从下一个较低的von Frey纤维开始重复检测该后爪，直到没有反应发生。试验包括给后爪施用von Frey纤维5次/每个后爪，间隔15秒。后爪回缩阈值定义为在施用连续5次时，引起3次回缩的最小的力。一旦左后爪的阈值确定，5分钟后在右后爪重复同样的试验。
哈格里夫后爪热敏感试验(Hargreave's test)。适应检测管之后，通过测定后爪对辐射热源回缩的潜伏期来测定热痛觉过敏。大鼠各自置于位于升起的平台上的有机玻璃笼中，平台下是通过玻璃板施用于足爪的辐射性热源(336型组合元件,IITC/life ScienceInstruments,Woodland Hill,CA,USA)当大鼠抬起足爪时关闭热源，测定从施用热源开始到大鼠后爪回缩的时间。
该时间被定义为后爪回缩潜伏期。在没有CCI时，维持在稳定强度的热源将产生稳定的回缩潜伏期(大约8-10秒)。在没有反应时，关闭20秒防止组织损伤。大鼠4只一组，以便在5分钟的间隔内可以对每只大鼠进行一次左后爪(对照)然后一次右后爪的刺激。这种方法再重复2次，每个脚爪测定三次取平均值。
结果
啮齿类模型中神经病理性疼痛的鉴定
为了揭示参与调整神经病理性疼痛信号途径的新的分子成分，发明人采用CCI作为啮齿类神经病理性疼痛模型(Bennett和Xie,1988；Moalem等,2004；Xie等,2005)来寻找CCI大鼠脊髓中差异表达的基因。由于发明人希望鉴定出参与神经病理性疼痛发展阶段的基因，他们首先确定了CCI模型中神经病理性疼痛发展的时间阶段。采用接受单侧CCI手术的S-D大鼠，测定出后爪热和触觉痛觉敏感性(从CCI术后2天开始)。
从图1A和图1B可以看出，在CCI术后第二天，CCI后爪与对照爪(即未手术侧)，热和触觉痛觉敏感性大大提高，几乎达到了最高值。这些结果与以前的研究(Khalil等，1999)一致，即CCI术后几天之内即会发生机械性痛觉异常和热痛觉过敏。基于这些神经病理性疼痛发展时间进程的信息，发明人选择CCI术后3天作为时间点，选择来自于对照组和CCI组腰椎膨大部分提取RNA，采用如前所述的(Hou等，2004；Jin等，2005；Wang等，2005)自定义构建的cDNA文库芯片进行微阵列分析。
在此过程中鉴定出的一个cDNA克隆是SIP30，即之前被报道与SNAP25相互作用的一种分子(Lee等，2002)。SIP30在大鼠大脑的几个区域都存在(Lee等，2002)，但其分子功能还不清楚。
如图2所示，SIP30同源类似物在几种哺乳动物(包括猩猩、猴子和几种非灵长类哺乳动物)中都有存在。这些序列是高度同源的。对GenBank和其他公共序列库的广泛检索显示SIP30序列存在于灵长类和其他哺乳动物中。
SIP30和小直径神经元标记物共定位。为了评价SIP30在不同中枢神经系统和外周神经组织中的表达模式进行了Northern印迹，结果表明SIP30主要在中枢神经系统表达(图3A-图3C)。这些结果能够支持之前的报道(Lee等，2002)。
之后对于SIP30在DRG的表达进行了研究。小直径DRG神经元主要是痛觉感受器，在神经化学上可以分为两个群：植物凝集素B4(IB4)–阳性的非肽能神经元和IB4–阴性的肽能神经元。IB4–阴性的神经元表达神经生长因子(NGF)的受体TrkA，依赖NGF生存，并含有神经肽(包括降钙素基因相关肽和P物质)。IB4–阳性的神经元表达神经胶质细胞系衍化神经营养因子(GDNF)、神经营养因子(neurturin)或青蒿琥酯(artemin)的受体。IB4–阳性和IB4-阴性痛觉感受器有着不同的功能(Stucky和Lewin,1999)。据假设，IB4-阴性神经元特异性地在炎症性疼痛中起作用，而IB4阳性神经元则在神经病理性疼痛中起作用(Mantyh和Hunt,1998；Snider和McMahon,1998；Breese等,2005)。
本发明研究了SIP30、IB4及CGRP在正常成年大鼠DRG(L4-L5)中的表达。SIP30在从小直径到中直径的DRG神经元中都有表达(图3A-图3C)。SIP30在某些神经元中与IB4和CGRP的表达有重叠，但主要是与CGRP(图3A-图3C)共同表达，这表明其肽能的本质。
本发明还对腰髓中SIP30的免疫反应活性进行了检测，发现它在所有的腰段都有表达。SIP30的免疫反应活性主要集中在脊髓背角表层(第I、II层)(图3A-图3C)，并表现出很强的与相关神经肽CGRP和P物质共表达的模式(图3A-图3C)。另外，SIP30免疫染色也出现在第IV-VII层细胞体和脊髓前角运动神经元中。
CCI术后SIP30在脊髓中的上调。CCI组和假手术组大鼠脊髓和DRG中SIP30mRNA的变化用定量实时PCR来检测。其它两种基因的表达水平作为参照以标准化每个样品中总RNA的量。首先采用定量实时PCR方法测定未手术组和CCI组大鼠脊髓和DRG中β-肌动蛋白和甘油醛-3-磷酸脱氢酶(GAPDH)的表达。CCI大鼠β-肌动蛋白和GAPDH的表达用未手术组标准化。结果表明，在脊髓和DRG中β-肌动蛋白的表达比GAPDH更一致(数据未显示)。因此，选择β-肌动蛋白作为本研究中的参照。CCI术后第3天和第7天，和假手术组及未手术组相比，SIP30mRNA在同侧脊髓中有统计学上显著的增高(p<0.05)，而在对侧脊髓没有观察到增高(图4A-图4E)。
然而，在DRG，SIP30 mRNA表达没有用因CCI手术而改变。假手术组和CCI大鼠同侧和对侧DRG没有差异(图4A-图4E)。
CCI大鼠脊髓的Western印迹分析也表明了SIP30蛋白的上调。和CCI大鼠的对侧以及假手术组大鼠的双侧相比，腰髓同侧观察到了增强的SIP30信号(图4A-图4E)。与CCI大鼠和假手术组大鼠SIP30 mRNA在DRG的表达相似，CCI术后，DRG双侧都没有观察到增强的Western印迹信号(图4A-图4E)。
CCI术后第3天和第7天，免疫染色显示脊髓同侧背角SIP30蛋白水平增高(图4A-图4E)。
考察了SIP30在CCI脊髓中的定位，结果表明，CCI术后第3天，在脊髓背角，SIP30和神经元特异性核蛋白(NeuN，一种神经元标记物)共定位(图4A-图4E)。SIP30和GFAP或OX-42染色时都没有重叠(图4A-图4E)。
这些结果显示，在CCI过程中，SIP30水平在脊髓的同侧上调了，显示SIP30水平和神经病理性疼痛的潜在相关性。
SIP30参与神经病理性疼痛的发展和维持。从第0天开始(CCI术前6小时)，SIP30AS(反义核酸)髓鞘内给药(50mg/10μl，每天一次×4天)，到SIP30给药的第4天，机械性痛觉异常和热痛觉敏感的发展都受到部分抑制(图5A-图5D)。双向ANOVA显示反义组和NS组之间存在统计学显著性差异(p<0.05)。AS给药停止后2天(CCI术后第5天)，AS组显示和NS组相似的机械性痛觉异常(图5A-图5D)。CCI术后第7天，出现热痛觉敏感的脚爪回缩潜伏期和NS组相似(图5A-图5D)。MM给药对机械性痛觉异常和热痛觉敏感的发展没有影响。对侧脚爪回缩阈值和潜伏期不受AS、MM和NS治疗的影响(图5A-图5D)。
为了进一步证实SIP30特异性作用，考察了用靶向SIP30基因编码区第143-162位核苷酸的第二个SIP30 AS ODN SEQ.ID.No.133(AS II:5'-GGC AAT CCT ACA GGT TCC AG-3')“敲降”SIP30蛋白功能的结果。该AS II还能使CCI诱导的机械性痛觉异常和热痛觉敏感减弱(图5A-图5D)。双向ANOVA表明反义组和一般对照组(随机ODN,5-ACG TAA GCA ACG CTCAGC TA-3')之间存在着统计学显著性差异。
CCI术后第3天，大鼠发生机械性痛觉异常和热痛觉敏感。在该点之后神经病理性疼痛建立，用SIP30 AS治疗后的第4天，在AS ODN治疗的后期CCI大鼠同侧脚爪回缩阈值和潜伏期增加，
双向ANOVA显示CCI术后第7天和第9天，在反义组和NS组或MM组之间存在着统计学显著性差异(p<0.05，图5A-图5D)。AS停药4天后，机械性痛觉异常和热痛觉敏感重新出现。MM ODN或NA都不能改变CCI大鼠对机械刺激和热刺激的脚爪回缩反应。给药期间和给药后，NS、AS和MM ODN对对侧后肢都没有影响(图5A-图5D)。
SIP30 AS ODN(50mg/10μl，每天一次×4天)治疗正常大鼠对于Von Frey和热刺激双侧后肢的反应都没有观察到任何影响(p>0.05，图5A-图5D)。另外，为了排除SIP30 ASODN鞘内给药可能产生非特异性运动缺陷的可能性，测定了接受SIP30 AS治疗的正常大鼠的自发性运动，在SIP30 AS ODN治疗期间没有观察到异常行为或运动缺陷(数据未显示)。
综上所述，这些发现显示抑制脊髓中抑制SIP30水平上调可使神经性疼痛发展阶段和维持阶段的神经性疼痛减弱，表明在SIP30上调和神经性疼痛现象之间存在着因果关系。
寡核苷酸敲降SIP30既能抑制SIP30又能抑制SNAP25在脊髓中的表达。考虑到CCI手术不能影响SIP30的mRNA或蛋白在DRG的表达，以下观察仅集中在脊髓。为了证实SIP30AS ODN髓鞘内给药是否确实能通过破坏SIP30 mRNA的翻译敲降SIP30，考察了SIP30 ASODN对SIP30 mRNA和SIP30蛋白的影响。鞘内注射SIP30 AS(50μg/10μl)和MM ODN(50μg/10μl)。最后一次注射6小时后收获脊髓的腰膨大部分。定量PCR显示，和给予SIP30 MM ODN相比，SIP30 AS ODN能显著性降低0-3天或4-7天SIP30 mRNA在同侧脊髓的表达(图6A-图6D)。另外，Western印迹显示，SIP30 AS在反复髓鞘内CCI术后给药3天后，能显著降低SIP30在大鼠同侧脊髓中的表达，而MM ODN却不能(图6A-图6D)，进一步支持AS能介导SIP30蛋白“敲降”。
为了评价SIP30 AS的选择性作用，我们还考察了在脊髓表达两个相关的突触蛋白(25kDa的突触小体相关蛋白(SNAP25)和突触后密度蛋白-95(PSD95))的作用。
如图6A-图6D所示，SNAP25mRNA在CCI术后3天和7天在同侧脊髓表现出显著的上调。而与此相反，直到CCI术后7天，才检测到PSD95mRNA在脊髓的变化。无论SIP30 AS或MMODN都不能阻碍CCI术后7天PSD95mRNA在同侧脊髓的上调(图6A-图6D)。
实施例2SIP30增加疼痛敏感的作用
在异氟醚麻醉下，CD-1小鼠鞘内注射SIP30和对照药(以质粒DNA的形式)。无论是使用含有SIP30序列的质粒还是空质粒，都同时给予脂质转染试剂。对照组小鼠(n＝6)每只接受2.0μg空质粒。对于含有SIP30的质粒，A组小鼠(n＝5)每只接受2.0μg SIP30质粒DNA，B组小鼠每只(n＝5)接受5.25μg SIP30质粒DNA。之后24天内，小鼠通过Von Frey纤维接受脚爪回缩阈值试验。
图7描述了试验结果。在试验的第4天、6天和8天，和对照组相比，A组和B组小鼠在脚爪回缩阈值都有显著差异(*，p<0.05，和对照组相比有显著差异)。测量包括每只小鼠的两侧脚爪。第24天时，脚爪回缩阈值回复到正常水平。本领域的普通技术人员可以理解，SIP30在加重神经病理性疼痛中起着直接作用。本发明的发现对于治疗方案中所需要的SIP30拮抗的时间和程度提供了充分的指导。
虽然本发明采用具体实施方式进行了描述，应当理解这些实施方式都只是为了具体描述本发明的原理和应用。因此可以理解，可以对本发明描述性的实施方式进行大量的改进和其他安排而不会偏离由权利要求定义的本发明的精神和范围。
序列表
<110> 新泽西鲁特格斯州立大学
<120> 治疗神经病理性疼痛的组合物及方法
<130> 70439.00492
<140> PCTUS1047657
<141> 2010-10-26
<150> 61/239,065
<151> 2009-09-02
<160> 263
<170> PatentIn version 3.5
<210> 1
<211> 1660
<212> DNA
<213> 人类
<400> 1
attgtgggaa ggcagctgaa ctcggcgcct ggaaagatgg aggcagcgga gacagaggcg 60
gaagctgcag ccctagaggt cctggctgag gtggcaggca tcttggaacc tgtaggcctg 120
caggaggagg cagaactgcc agccaagatc ctggttgagt ttgtggtgga ctctcagaag 180
aaagacaagc tgctctgcag ccagcttcag gtagcggatt tcctgcagaa catcctggct 240
caggaggaca ctgctaaggg tctcgacccc ttggcttctg aagacacgag ccgacagaag 300
gcaattgcag ctaaggaaca atggaaagag ctgaaggcca cctacaggga gcacgtagag 360
gccatcaaaa ttggcctcac caaggccctg actcagatgg aggaagccca gaggaaacgg 420
acacaactcc gggaagcctt tgagcagctc caggccaaga aacaaatggc catggagaaa 480
cgcagagcag tccagaacca gtggcagcta caacaggaga agcatctgca gcatctggcg 540
gaggtttctg cagaggtgag ggagcgtaag acagggactc agcaggagct tgacggggtg 600
tttcagaaac ttggaaacct gaagcagcag gcagaacagg agcgggacaa gctgcagagg 660
tatcagacct tcctccagct tctgtatacc ctgcagggta agctgttgtt ccctgaggct 720
gaggctgagg cagagaatct tccagatgat aaaccccagc agccgactcg accccaggag 780
cagagtacag gagacaccat ggggagagac cctggtgtgt ccttcaaggc tgttggtcta 840
caacctgctg gagatgtaaa tttgccatga cttcctggag gacagcagca tggagaaaga 900
tcctagaaaa ggcctctgac ttccctcacc tcccaaccat cattacagga aagactgtga 960
actcctgagt tcagcttgat ttctgactac atcccagcaa gctctggcat ctgtggatta 1020
aaatccctgg atctctctca gttgtgtatt tgttcatctt catatgctgg caggaacaac 1080
tattaataca gatactcaga agccaataac atgacaggag ctgggactgg tttgaacaca 1140
gggtgtgcag atggggaggg ggtactggcc ttgggcctcc tatgatgcag acatggtgaa 1200
tttaattcaa ggaggaggag aatgttttag gcaggtggtt atatgtggga agataatttt 1260
attcatggat ccaaatgttt gttgagtcct ttctttgtgc taaggttctt gcggtgaacc 1320
agaattataa cagtgagctc atctgactgt tttaggatgt acagcctagt gttaacattc 1380
ttggtatctt tttgtgcctt atctaaaaca tttctcgatc actggtttca gatgttcatt 1440
tattatattc ttttcaaaga ttcagagatt ggcttttgtc atccactatt gtatgttttg 1500
tttcattgac ctctagtgat accttgatct ttcccacttt ctgttttcgg attggagaag 1560
atgtaccttt tttgtcaact cttactttta tcagatgatc aactcacgta tttggatctt 1620
tatttgtttt ctcaaataaa tatttaaggt taaaaaaaaa 1660
<210> 2
<211> 1660
<212> DNA
<213> 人类
<400> 2
gattgtggga aggcagctga actcggcgcc tggaaagatg gaggcagcgg agacagaggc 60
ggaagctgca gccctagagg tcctggctga ggtggcaggc atcttggaac ctgtaggcct 120
gcaggaggag gcagaactgc cagccaagat cctggttgag tttgtggtgg actctcagaa 180
gaaagacaag ctgctctgca gccagcttca ggtagcggat ttcctgcaga acatcctggc 240
tcaggaggac actgctaagg gtctcgaccc cttggcttct gaagacacga gccgacagaa 300
ggcaattgca gctaaggaac aatggaaaga gctgaaggcc acctacaggg agcacgtaga 360
ggccatcaaa attggcctca ccaaggccct gactcagatg gaggaagccc agaggaaacg 420
gacacaactc cgggaagcct ttgagcagct ccaggccaag aaacaaatgg ccatggagaa 480
acgcagagca gtccagaacc agtggcagct acaacaggag aagcatctgc agcatctggc 540
ggaggtttct gcagaggtga gggagcgtaa gacagggact cagcaggagc ttgacagggt 600
gtttcagaaa cttggaaacc tgaagcagca ggcagaacag gagcgggaca agctgcagag 660
gtatcagacc ttcctccagc ttctgtatac cctgcagggt aagctgttgt tccctgaggc 720
tgaggctgag gcagagaatc ttccagatga taaaccccag cagccgactc gaccccagga 780
gcagagtaca ggagacacca tggggagaga ccctggtgtg tccttcaagg ctgttggtct 840
acaacctgct ggagatgtaa atttgccatg acttcctgga ggacagcagc atggagaaag 900
atcctagaaa aggcctctga cttccctcac ctcccaacca tcattacagg aaagactgtg 960
aactcctgag ttcagcttga tttctgacta catcccagca agctctggca tctgtggatt 1020
aaaatccctg gatctctctc agttgtgtat ttgttcatct tcatatgctg gcaggaacaa 1080
ctattaatac agatactcag aagccaataa catgacagga gctgggactg gtttgaacac 1140
agggtgtgca gatggggagg gggtactggc cttgggcctc ctatgatgca gacatggtga 1200
atttaattca aggaggagga gaatgtttta ggcaggtggt tatatgtggg aagataattt 1260
tattcatgga tccaaatgtt tgttgagtcc tttctttgtg ctaaggttct tgcggtgaac 1320
cagaattata acagtgagct catctgactg ttttaggatg tacagcctag tgttaacatt 1380
cttggtatct ttttgtgcct tatctaaaac atttctcgat cactggtttc agatgttcat 1440
ttattatatt cttttcaaag attcagagat tggcttttgt catccactat tgtatgtttt 1500
gtttcattga cctctagtga taccttgatc tttcccactt tctgttttcg gattggagaa 1560
gatgtacctt ttttgtcaac tcttactttt atcagatgat caactcacgt atttggatct 1620
ttatttgttt tctcaaataa atatttaagg ttatacattt 1660
<210> 3
<211> 1852
<212> DNA
<213> 人类
<400> 3
gattgtggga aggcagctga actcggcgcc tggaaagatg gaggcagcgg agacagaggc 60
ggaagctgca gccctagagg tcctggctga ggtggcaggc atcttggaac ctgtaggcct 120
gcaggaggag gcagaactgc cagccaagat cctggttgag tttgtggtgg actctcagaa 180
gaaagacaag ctgctctgca gccagcttca ggtagcggat ttcctgcaga acatcctggc 240
tcaggaggac actgctaagg gtctcgaccc cttggcttct gaagacacga gccgacagaa 300
ggcaattgca gctaaggaac aatggaaaga gctgaaggcc acctacaggg agcacgtaga 360
ggccatcaaa attggcctca ccaaggccct gactcagatg gaggaagccc agaggaaacg 420
gacacaactc cgggaagcct ttgagcagct ccaggccaag aaacaaatgg ccatggagaa 480
acgcagagca gtccagaacc agtggcagct acaacaggag aagcatctgc agcatctggc 540
ggaggtttct gcagaggtga gggagcgtaa gacagggact cagcaggagc ttgacagggt 600
gtttcagaaa cttggaaacc tgaagcagca ggcagaacag gagcgggaca agctgcagag 660
gtatcagacc ttcctccagc ttctgtatac cctgcagggt aagctgttgt tccctgaggc 720
tgaggctgag gcagagaatc ttccagatga taaaccccag cagccgactc gaccccagga 780
gcagagtaca ggagacacca tggggagaga ccctggtgtg tccttcaagg ctgttggtct 840
acaacctgct ggagatgtaa atttgccatg acttcctgga ggacagcagc atggagaaag 900
atcctagaaa aggtcagacc caactcaggc cttggtgtcc ctggactgca agtgtggaag 960
gagggaaagc ctggtttacc tctctctgca tctgagctct gctacccatg gagcagatgg 1020
atggtgggaa caggaaagag cttatgttac acctcattcc catgcttagc ccacccagag 1080
ctaacccctg tcttcttccc caggcctctg acttccctca cctcccaacc atcattacag 1140
gaaagactgt gaactcctga gttcagcttg atttctgact acatcccagc aagctctggc 1200
atctgtggat taaaatccct ggatctctct cagttgtgta tttgttcatc ttcatatgct 1260
ggcaggaaca actattaata cagatactca gaagccaata acatgacagg agctgggact 1320
ggtttgaaca cagggtgtgc agatggggag ggggtactgg ccttgggcct cctatgatgc 1380
agacatggtg aatttaattc aaggaggagg agaatgtttt aggcaggtgg ttatatgtgg 1440
gaagataatt ttattcatgg atccaaatgt ttgttgagtc ctttctttgt gctaaggttc 1500
ttgcggtgaa ccagaattat aacagtgagc tcatctgact gttttaggat gtacagccta 1560
gtgttaacat tcttggtatc tttttgtgcc ttatctaaaa catttctcga tcactggttt 1620
cagatgttca tttattatat tcttttcaaa gattcagaga ttggcttttg tcatccacta 1680
ttgtatgttt tgtttcattg acctctagtg ataccttgat ctttcccact ttctgttttc 1740
ggattggaga agatgtacct tttttgtcaa ctcttacttt tatcagatga tcaactcacg 1800
tatttggatc tttatttgtt ttctcaaata aatatttaag gttatacatt ta 1852
<210> 4
<211> 1520
<212> DNA
<213> 人类
<400> 4
gattgtggga aggcagctga actcggcgcc tggaaagatg gaggcagcgg agacagaggc 60
ggaagctgca gccctagagg tcctggctga ggtggcaggc atcttggaac ctgtaggcct 120
gcaggaggag gcagaactgc cagccaagat cctggttgag tttgtggtgg actctcagaa 180
gaaagacaag ctgctctgca gccagcttca ggtagcggat ttcctgcaga acatcctggc 240
tcaggaggac actgctaagg gtctcgaccc cttggcttct gaagacacga gccgacagaa 300
ggcaattgca gctaaggaac aatggaaaga gctgaaggcc acctacaggg agcacgtaga 360
ggccatcaaa attggcctca ccaaggccct gactcagatg gaggaagccc agaggaaacg 420
gacacaactc cgggaagcct ttgagcagct ccaggccaag aaacaaatgg ccatggagaa 480
acgcagagca gtccagaacc agtggcagct acaacaggag aagcatctgc agcatctggc 540
ggaggtttct gcagagggta agctgttgtt ccctgaggct gaggctgagg cagagaatct 600
tccagatgat aaaccccagc agccgactcg accccaggag cagagtacag gagacaccat 660
ggggagagac cctggtgtgt ccttcaaggc tgttggtcta caacctgctg gagatgtaaa 720
tttgccatga cttcctggag gacagcagca tggagaaaga tcctagaaaa ggcctctgac 780
ttccctcacc tcccaaccat cattacagga aagactgtga actcctgagt tcagcttgat 840
ttctgactac atcccagcaa gctctggcat ctgtggatta aaatccctgg atctctctca 900
gttgtgtatt tgttcatctt catatgctgg caggaacaac tattaataca gatactcaga 960
agccaataac atgacaggag ctgggactgg tttgaacaca gggtgtgcag atggggaggg 1020
ggtactggcc ttgggcctcc tatgatgcag acatggtgaa tttaattcaa ggaggaggag 1080
aatgttttag gcaggtggtt atatgtggga agataatttt attcatggat ccaaatgttt 1140
gttgagtcct ttctttgtgc taaggttctt gcggtgaacc agaattataa cagtgagctc 1200
atctgactgt tttaggatgt acagcctagt gttaacattc ttggtatctt tttgtgcctt 1260
atctaaaaca tttctcgatc actggtttca gatgttcatt tattatattc ttttcaaaga 1320
ttcagagatt ggcttttgtc atccactatt gtatgttttg tttcattgac ctctagtgat 1380
accttgatct ttcccacttt ctgttttcgg attggagaag atgtaccttt tttgtcaact 1440
cttactttta tcagatgatc aactcacgta tttggatctt tatttgtttt ctcaaataaa 1500
tatttaaggt tatacattta 1520
<210> 5
<211> 1640
<212> DNA
<213> 人类
<400> 5
cagctgaact cggcgcctgg aaagatggag gcagcggaga cagaggcgga agctgcagcc 60
ctagaggtcc tggctgaggt ggcaggcatc ttggaacctg taggcctgca ggaggaggca 120
gaactgccag ccaagatcct ggttgagttt gtggtggact ctcagaagaa agacaagctg 180
ctctgcagcc agcttcaggt agcggatttc ctgcagaaca tcctggctca ggaggacact 240
gctaagggtc tcgacccctt ggcttctgaa gacacgagcc gacagaaggc aattgcagct 300
aaggaacaat ggaaagagct gaaggccacc tacagggagc acgtagaggc catcaaaatt 360
ggcctcacca aggccctgac tcagatggag gaagcccaga ggaaacggac acaactccgg 420
gaagcctttg agcagctcca ggccaagaaa caaatggcca tggagaaacg cagagcagtc 480
cagaaccagt ggcagctaca acaggagaag catctgcagc atctggcgga ggtttctgca 540
gaggtgaggg agcgtaagac agggactcag caggagcttg acggggtgtt tcagaaactt 600
ggaaacctga agcagcaggc agaacaggag cgggacaagc tgcagaggta tcagaccttc 660
ctccagcttc tgtataccct gcagggtaag ctgttgttcc ctgaggctga ggctgaggca 720
gagaatcttc cagatgataa accccagcag ccgactcgac cccaggagca gagtacagga 780
gacaccatgg ggagagaccc tggtgtgtcc ttcaaggctg ttggtctaca acctgctgga 840
gatgtaaatt tgccatgact tcctggagga cagcagcatg gagaaagatc ctagaaaagg 900
cctctgactt ccctcacctc ccaaccatca ttacaggaaa gactgtgaac tcctgagttc 960
agcttgattt ctgactacat cccagcaagc tctggcatct gtggattaaa atccctggat 1020
ctctctcagt tgtgtatttg ttcatcttca tatgctggca ggaacaacta ttaatacaga 1080
tactcagaag ccaataacat gacaggagct gggactggtt tgaacacagg gtgtgcagat 1140
ggggaggggg tactggcctt gggcctccta tgatgcagac atggtgaatt taattcaagg 1200
aggaggagaa tgttttaggc aggtggttat atgtgggaag ataattttat tcatggatcc 1260
aaatgtttgt tgagtccttt ctttgtgcta aggttcttgc ggtgaaccag aattataaca 1320
gtgagctcat ctgactgttt taggatgtac agcctagtgt taacattctt ggtatctttt 1380
tgtgccttat ctaaaacatt tctcgatcac tggtttcaga tgttcattta ttatattctt 1440
ttcaaagatt cagagattgg cttttgtcat ccactattgt atgttttgtt tcattgacct 1500
ctagtgatac cttgatcttt cccactttct gttttcggat tggagaagat gtaccttttt 1560
tgtcaactct tacttttatc agatgatcaa ctcacgtatt tggatcttta tttgttttct 1620
caaataaata tttaaggtta 1640
<210> 6
<211> 1640
<212> DNA
<213> 人类
<400> 6
ggcacgagct cggctcctgg aaagatggag gcagcggaga cagaggcgga agctgcagcc 60
ctagaggtcc tggctgaggt ggcaggcatc ttggaacctg taggcctgca ggaggaggca 120
gaactgccag ccaagatcct ggttgagttt gtggtggact ctcagaagaa agacaagctg 180
ctctgcagcc agcttcaggt agcggatttc ctgcagaaca tcctggctca ggaggacact 240
gctaagggtc tcgacccctt ggcttctgaa gacacgagcc gacagaaggc aattgcagct 300
aaggaacaat ggaaagagct gaaggccacc tacagggagc acgtagaggc catcaaaatt 360
ggcctcacca aggccctgac tcagatggag gaagcccaga ggaaacggac acaactccgg 420
gaagcctttg agcagctcca ggccaagaaa caaatggcca tggagaaacg cagagcagtc 480
cagaaccagt ggcagctaca acaggagaag catctgcagc atctggcgga ggtttctgca 540
gaggtgaggg agcgtaagac agggactcag caggagcttg acggggtgtt tcagaaactt 600
ggaaacctga agcagcaggc agaacaggag cgggacaagc tgcagaggta tcagaccttc 660
ctccagcttc tgtataccct gcagggtaag ctgttgttcc ctgaggctga ggctgaggca 720
gagaatcttc cagatgataa accccagcag ccgactcgac cccaggagca gagtacagga 780
gacaccatgg ggagagaccc tggtgtgtcc ttcaaggctg ttggtctaca acctgctgga 840
gatgtaaatt tgccatgact tcctggagga cagcagcatg gagaaagatc ctagaaaagg 900
cctctgactt ccctcacctc ccaaccatca ttacaggaaa gactgtgaac tcctgagttc 960
agcttgattt ctgactacat cccagcaagc tctggcatct gtggattaaa atccctggat 1020
ctctctcagt tgtgtatttg ttcatcttca tatgctggca ggaacaacta ttaatacaga 1080
tactcagaag ccaataacat gacaggagct gggactggtt tgaacacagg gtgtgcagat 1140
ggggaggggg tactggcctt gggcctccta tgatgcagac atggtgaatt taattcaagg 1200
aggaggagaa tgttttaggc aggtggttat atgtgggaag ataattttat tcatggatcc 1260
aaatgtttgt tgagtccttt ctttgtgcta aggttcttgc ggtgaaccag aattataaca 1320
gtgagctcat ctgactgttt taggatgtac agcctagtgt taacattctt ggtatctttt 1380
tgtgccttat ctaaaacatt tctcgatcac tggtttcaga tgttcattta ttatattctt 1440
ttcaaagatt cagagattgg cttttgtcat ccactattgt atgttttgtt tcattgacct 1500
ctagtgatac cttgatcttt cccactttct gttttcggat tggagaagat gtaccttttt 1560
tgtcaactct tacttttatc agatgatcaa ctcacgtatt tggatcttta tttgttttct 1620
caaataaata tttaaggtta 1640
<210> 7
<211> 2430
<212> DNA
<213> 黑猩猩C性内性逆转录病毒
<400> 7
gggattgtgg gaaggcagct gaactcggcg cctggaaaga tggaggcagc ggagacagag 60
gcggaagctg cagccctaga ggtcctggct gaggtggcag gcatcctgga acctgtaggc 120
ctgcaggagg aggcagaact gccagccaag atcctggttg agtttgtggt ggactctcag 180
aagaaagaca agctgctctg cagccagctt caggtagcgg atttcctgca gaacatcctg 240
gctcaggagg acactgctaa gggtctcgac cccttggctt ctgaagacac gagccggcag 300
aaggcaattg cagctaagga acaatggaaa gagctgaagg ccacctacag ggagcacgta 360
gaggccatca aaattggcct caccaaggcc ctgactcaga tggaggaagc ccagaggaaa 420
cggacacaac tccaggaagc ctttgagcag ctccaggcca agaaacaaat ggccatggag 480
aaacgcagag cagtccagaa ccagtggcag ctacaacagg agaagcatct gcagcatctg 540
gcggaggttt ctgcagaggg taagctgttg ttccctgagg ctgaggctga ggcagagaat 600
cttccagatg ataaacccca gcagccgact cgaccccagg agcagagtac aggagacacc 660
atggggagag accctggtgt gtccttcaag gctgtcggtc tacaacctgc tggagatgca 720
aatttgccat gacttcctgg aggacagcag catggagaaa gatcctagaa aaggtcagac 780
ccaactcagg ccttggtgtc cctggactgc aagtgtggaa ggagggaaag cctggtttac 840
ctctctctgc atctgagctc tgctacccat ggagcagacg gatggtggga acaggaaaga 900
gcttatgtta cacctcattc ccatgcttag cccacccaga gctaacccct gtcttcttcc 960
ccaggcctct gacttccctc acctcccaac catcattaca ggaaagactg tgaactcctg 1020
agttcagctt gatttctgac tacatcccag caagctctgg catctgtgga ttaaaatccc 1080
tggatctctc tcagttgtgt atttgttcat attcatatgc tggcaggaac aactattaat 1140
acagatactc agaagccaat aacatgacag gagctgggac tggtttgaac acagggtgtg 1200
cagatgggga gggggtactg gccttgggcc tcaggggttg cttcccccta tgatgcagac 1260
atggtgaatt taattcaagg aggaggagaa tgttttaggc aggtggttat atgtgggaag 1320
ataatttatt cactaatcca aattgtattc atggatccaa atgtttgttg agtcctttct 1380
ttgtgctaag gttcttgcgg tgaaccagaa ttataacagt gagctcatct gactgtttta 1440
ggatgtacag cctagtgtta acattcttgg tatctttttg tgccttatct aaaacatttc 1500
tcgatcactg gtttcagatg ttcatgtatt atattctttt caaagattca gagattggct 1560
tttgtcatcc actattgtat gttttgtttc attgacctct agtgatacct tgatctttcc 1620
cactttctgt tttcggatgg agaagatgta ccttttttgt caactcttac ttttatcaga 1680
tgatcaactc atgtatttgg atctttattt gttttctcaa atatttaagg ttatacattt 1740
cttctgactt cctttatttt cacaatcatt caattcatag catttcctat attctgttat 1800
aattatttca ttgattcata aatttctttg aaaaataatt tggtcttcta ttgattgtga 1860
gaagataatc taagtttaat ttggtcagag aatatcatct atttaacaaa ctttgtaatt 1920
tggtgagtga attatctttt ttactgataa agagtgatgt catctttttt aatgtttcac 1980
ataggtttgg aaagaatgca ttttagattg tgtgtagtat tttctattag attatgtttg 2040
caatttttgt ttcaatttat atcttatata cttaattttt tgttgtctat cacctgagag 2100
gtgtgttcaa atctccaact atgatagtgg atttgttcat ttgtctttat agttccattt 2160
tcttacatac tttgcagcta ctttattaag gtatatgtaa atttacattt atatttttct 2220
tctgaactga actctttgtg tggtagcctg cttcatctat aggctaatgt gtttaacctt 2280
gaaaactaat agttttaata gtaatataac tttgtcactt cttttggtta ccctttgctt 2340
gacatccttt ctcttgaatt tccattcttt tttagtttca acctttcttt atatttacca 2400
cttgtataca gcatttaaag ggttatttat 2430
<210> 8
<211> 2350
<212> DNA
<213> 黑猩猩C性内性逆转录病毒
<400> 8
gggattgtgg gaaggcagct gaactcggcg cctggaaaga tggaggcagc ggagacagag 60
gcggaagctg cagccctaga ggtcctggct gaggtggcag gcatcctgga acctgtaggc 120
ctgcaggagg aggcagaact gccagccaag atcctggttg agtttgtggt ggactctcag 180
aagaaagaca agctgctctg cagccagctt caggtagcgg atttcctgca gaacatcctg 240
gctcaggagg acactgctaa gggtctcgac cccttggctt ctgaagacac gagccggcag 300
aaggcaattg cagctaagga acaatggaaa gagctgaagg ccacctacag ggagcacgta 360
gaggccatca aaattggcct caccaaggcc ctgactcaga tggaggaagc ccagaggaaa 420
cggacacaac tccaggaagc ctttgagcag ctccaggcca agaaacaaat ggccatggag 480
aaacgcagag cagtccagaa ccagtggcag ctacaacagg agaagcatct gcagcatctg 540
gcggaggttt ctgcagaggt gagggagcgt aagacaggga ctcagcaggc gcttgagggg 600
gtgtttcaga aacttggaaa cctgaagcag caggcagaac aggagcggga caagctgcag 660
agggtaagct gttgttccct gaggctgagg ctgaggcaga gaatcttcca gatgataaac 720
cccagcagcc gactcgaccc caggagcaga gtacaggaga caccatgggg agagaccctg 780
gtgtgtcctt caaggctgtc ggtctacaac ctgctggaga tgcaaatttg ccatgacttc 840
ctggaggaca gcagcatgga gaaagatcct agaaaaggcc tctgacttcc ctcacctccc 900
aaccatcatt acaggaaaga ctgtgaactc ctgagttcag cttgatttct gactacatcc 960
cagcaagctc tggcatctgt ggattaaaat ccctggatct ctctcagttg tgtatttgtt 1020
catattcata tgctggcagg aacaactatt aatacagata ctcagaagcc aataacatga 1080
caggagctgg gactggtttg aacacagggt gtgcagatgg ggagggggta ctggccttgg 1140
gcctcagggg ttgcttcccc ctatgatgca gacatggtga atttaattca aggaggagga 1200
gaatgtttta ggcaggtggt tatatgtggg aagataattt attcactaat ccaaattgta 1260
ttcatggatc caaatgtttg ttgagtcctt tctttgtgct aaggttcttg cggtgaacca 1320
gaattataac agtgagctca tctgactgtt ttaggatgta cagcctagtg ttaacattct 1380
tggtatcttt ttgtgcctta tctaaaacat ttctcgatca ctggtttcag atgttcatgt 1440
attatattct tttcaaagat tcagagattg gcttttgtca tccactattg tatgttttgt 1500
ttcattgacc tctagtgata ccttgatctt tcccactttc tgttttcgga tggagaagat 1560
gtaccttttt tgtcaactct tacttttatc agatgatcaa ctcatgtatt tggatcttta 1620
tttgttttct caaatattta aggttataca tttcttctga cttcctttat tttcacaatc 1680
attcaattca tagcatttcc tatattctgt tataattatt tcattgattc ataaatttct 1740
ttgaaaaata atttggtctt ctattgattg tgagaagata atctaagttt aatttggtca 1800
gagaatatca tctatttaac aaactttgta atttggtgag tgaattatct tttttactga 1860
taaagagtga tgtcatcttt tttaatgttt cacataggtt tggaaagaat gcattttaga 1920
ttgtgtgtag tattttctat tagattatgt ttgcaatttt tgtttcaatt tatatcttat 1980
atacttaatt ttttgttgtc tatcacctga gaggtgtgtt caaatctcca actatgatag 2040
tggatttgtt catttgtctt tatagttcca ttttcttaca tactttgcag ctactttatt 2100
aaggtatatg taaatttaca tttatatttt tcttctgaac tgaactcttt gtgtggtagc 2160
ctgcttcatc tataggctaa tgtgtttaac cttgaaaact aatagtttta atagtaatat 2220
aactttgtca cttcttttgg ttaccctttg cttgacatcc tttctcttga atttccattc 2280
ttttttagtt tcaacctttc tttatattta ccacttgtat acagcattta aagggttatt 2340
tataaaaaaa 2350
<210> 9
<211> 2580
<212> DNA
<213> 黑猩猩C性内性逆转录病毒
<400> 9
gggattgtgg gaaggcagct gaactcggcg cctggaaaga tggaggcagc ggagacagag 60
gcggaagctg cagccctaga ggtcctggct gaggtggcag gcatcctgga acctgtaggc 120
ctgcaggagg aggcagaact gccagccaag atcctggttg agtttgtggt ggactctcag 180
aagaaagaca agctgctctg cagccagctt caggtagcgg atttcctgca gaacatcctg 240
gctcaggagg acactgctaa gggtctcgac cccttggctt ctgaagacac gagccggcag 300
aaggcaattg cagctaagga acaatggaaa gagctgaagg ccacctacag ggagcacgta 360
gaggccatca aaattggcct caccaaggcc ctgactcaga tggaggaagc ccagaggaaa 420
cggacacaac tccaggaagc ctttgagcag ctccaggcca agaaacaaat ggccatggag 480
aaacgcagag cagtccagaa ccagtggcag ctacaacagg agaagcatct gcagcatctg 540
gcggaggttt ctgcagaggt gagggagcgt aagacaggga ctcagcaggc gcttgagggg 600
gtgtttcaga aacttggaaa cctgaagcag caggcagaac aggagcggga caagctgcag 660
aggtatcaga ccttcctcca gcttctgtat accctgcagg gtaagctgtt gttccctgag 720
gctgaggctg aggcagagaa tcttccagat gataaacccc agcagccgac tcgaccccag 780
gagcagagta caggagacac catggggaga gaccctggtg tgtccttcaa ggctgtcggt 840
ctacaacctg ctggagatgc aaatttgcca tgacttcctg gaggacagca gcatggagaa 900
agatcctaga aaaggtcaga cccaactcag gccttggtgt ccctggactg caagtgtgga 960
aggagggaaa gcctggttta cctctctctg catctgagct ctgctaccca tggagcagac 1020
ggatggtggg aacaggaaag agcttatgtt acacctcatt cccatgctta gcccacccag 1080
agctaacccc tgtcttcttc cccaggcctc tgacttccct cacctcccaa ccatcattac 1140
aggaaagact gtgaactcct gagttcagct tgatttctga ctacatccca gcaagctctg 1200
gcatctgtgg attaaaatcc ctggatctct ctcagttgtg tatttgttca tattcatatg 1260
ctggcaggaa caactattaa tacagatact cagaagccaa taacatgaca ggagctggga 1320
ctggtttgaa cacagggtgt gcagatgggg agggggtact ggccttgggc ctcaggggtt 1380
gcttccccct atgatgcaga catggtgaat ttaattcaag gaggaggaga atgttttagg 1440
caggtggtta tatgtgggaa gataatttat tcactaatcc aaattgtatt catggatcca 1500
aatgtttgtt gagtcctttc tttgtgctaa ggttcttgcg gtgaaccaga attataacag 1560
tgagctcatc tgactgtttt aggatgtaca gcctagtgtt aacattcttg gtatcttttt 1620
gtgccttatc taaaacattt ctcgatcact ggtttcagat gttcatgtat tatattcttt 1680
tcaaagattc agagattggc ttttgtcatc cactattgta tgttttgttt cattgacctc 1740
tagtgatacc ttgatctttc ccactttctg ttttcggatg gagaagatgt accttttttg 1800
tcaactctta cttttatcag atgatcaact catgtatttg gatctttatt tgttttctca 1860
aatatttaag gttatacatt tcttctgact tcctttattt tcacaatcat tcaattcata 1920
gcatttccta tattctgtta taattatttc attgattcat aaatttcttt gaaaaataat 1980
ttggtcttct attgattgtg agaagataat ctaagtttaa tttggtcaga gaatatcatc 2040
tatttaacaa actttgtaat ttggtgagtg aattatcttt tttactgata aagagtgatg 2100
tcatcttttt taatgtttca cataggtttg gaaagaatgc attttagatt gtgtgtagta 2160
ttttctatta gattatgttt gcaatttttg tttcaattta tatcttatat acttaatttt 2220
ttgttgtcta tcacctgaga ggtgtgttca aatctccaac tatgatagtg gatttgttca 2280
tttgtcttta tagttccatt ttcttacata ctttgcagct actttattaa ggtatatgta 2340
aatttacatt tatatttttc ttctgaactg aactctttgt gtggtagcct gcttcatcta 2400
taggctaatg tgtttaacct tgaaaactaa tagttttaat agtaatataa ctttgtcact 2460
tcttttggtt accctttgct tgacatcctt tctcttgaat ttccattctt ttttagtttc 2520
aacctttctt tatatttacc acttgtatac agcatttaaa gggttattta taaaaaaaaa 2580
<210> 10
<211> 1770
<212> DNA
<213> 褐家鼠
<400> 10
ggcgtggtgg gcgtcagaac catggcggac gcggagaaaa acgctgttgc ggagaaaaac 60
gctgttgcgg aggaaaacgc cgttgcggag gaaaacgccg ttgcggataa aaacgcaacg 120
aaagaggttc tggctgaggc agcaagcgtt ctggaacctg taggattgcc ggaagaagca 180
gagctgcctg ccaagatcat ggaggaattt atgaggaact ctcggaagaa agacaagctg 240
ctctgtagcc agcttcaagt agtgaacttc ttacagactt ttctggccca ggaggataat 300
actgaccaga acccagatgc tctggcttct gaagatacaa gtcgacaaaa ggcaactgaa 360
actaaggagc agtggaagga gctgaaggca acatacatgg atcatgtgga cgtcatcaaa 420
tgtgccctgt ctgaggcctt gccccaggtt aaagaggcac acaggaagta caccgagctt 480
cagaaggctt ttgagcaact cgaggctaag aagcgagtcc ttgaggagaa actgcagtta 540
gctcagaagc agtgggtgct gcagcagaag cgtttgcaga atctgacaaa gatttctgct 600
gaggtcaaga gacgccggaa gagagctctg gagaagcttg atggttctca ccaggaactt 660
gaaaccttga agcagcaagc aggacaggag caggagaagc tgcagaggaa ccagagctac 720
ctccagctgc tgtgctccct gcagaataag ctggtcatct ctgagtccaa ggccgacgac 780
aaagatgtca aagggcccgc ccttccaccc aagtctccgt aaagatgaaa gcgagaacga 840
gactgcgctc cagctgtgct gcttgggctg agaccagagt ggttccttcg ctgttgtatc 900
cctaggccta ggcctgtagc cttgtacaat cttccaagcg gactcagttt ggcatctctt 960
ggcttctcag tgaattgttc tgtttcattt cttaccatat attctggctt gttctgtctt 1020
cacctgggtc caacctgctg tttctgtaaa attgtgccag tgaaattgtc acgtgcatgc 1080
acgcaggcac acaggcacgc atgccacaac cacccttttc tctcgctgat cttcagtagt 1140
ctctcctctg gccctctctc tctctgtctt ctctcccgac cagatgtgaa agtaacttta 1200
tgcacccgat gtaattgttg cctcggaggc tcattgatga ataagctcac cctgtgtagt 1260
tcttgctaaa ctctggctgg ctggttcaac tcagctcttc tggttcaaac ccgtctccaa 1320
actgactgat tgaaacaggc ctctcttggc ttggaaagtc tgctctgaac tccagaactg 1380
aacggtactg actgcactga ctcgactgaa cgaaactgca ccgagttgat tgactccttc 1440
tccctttact gctcttaagt accctctctt ccctgtgctg tcctcctgag tcatgctgcc 1500
aaatctttct ctgattcatc acttcgcccc tcaattaaac tggcaatttc aaacgtggca 1560
cttagcattt cagttgtagt cacttaatac tgcattcaga acttgagtct attgaatcca 1620
taatgtgaaa ccatgtcttc gtgactgtga cctcactact cagtattgtg taaaagtttt 1680
aggaactctc caagtaagca cttggtattt gctcattgat agaacagaaa aatgctgtgt 1740
agataataaa taaacacggc tataagatta 1770
<210> 11
<211> 1765
<212> DNA
<213> 褐家鼠
<400> 11
gggggtcaga accatggcgg acgcggagaa aaacgctgtt gcggagaaaa acgctgttgc 60
ggaggaaaac gccgttgcgg aggaaaacgc cgttgcggat aaaaacgcaa cgaaagaggt 120
tctggctgag gcagcaagcg ttctggaacc tgtaggattg ccggaagaag cagagctgcc 180
tgccaagatc atggaggaat ttatgaggaa ctctcggaag aaagacaagc tgctctgtag 240
ccagcttcaa gtagtgaact tcttacagac ttttctggcc caggaggata atactgacca 300
gaacccagat gctctggctt ctgaagatac aagtcgacaa aaggcaactg aaactaagga 360
gcagtggaag gagctgaagg caacatacat ggatcatgtg gacgtcatca aatgtgccct 420
gtctgaggcc ttgccccagg ttaaagaggc acacaggaag tacaccgagc ttcagaaggc 480
ttttgagcaa ctcgaggcta agaagcgagt ccttgaggag aaactgcagt tagctcagaa 540
gcagtgggtg ctgcagcaga agcgtttgca gaatctgaca aagatttctg ctgaggtcaa 600
gagacgccgg aagagagctc tggagaagct tgatggttct caccaggaac ttgaaacctt 660
gaagcagcaa gcaggacagg agcaggagaa gctgcagagg aaccagagct acctccagct 720
gctgtgctcc ctgcagaata agctggtcat ctctgagtcc aaggccgacg acaaagatgt 780
caaagggccc gcccttccac ccaagtctcc gtaaagatga aagcgagaag agagctgcgc 840
tccagctgtg ctgcttgggc tgagaccaga gtggttcctt cgctgttgta tccctaggcc 900
taggcctgta gccttgtaca atcttccaag cggactcagt ttggcatctc ttggcttctc 960
agtgaattgt tctgtttcat ttcttaccat atattctggc ttgttctgtc ttcacctggg 1020
tccaacttgc tgtttctgta aaattgtgcc agtgaaattg tcacgtgcat gcacgcaggc 1080
acacaggcac gcatgccaca accacccttt tctctcgctg atcttcagta gtctctcctc 1140
tggccctctc tctctctgtc ttctctcccg accagatgtg aaagtaactt tatgcacccg 1200
atgtaattgt tgcctcggag gctcattgat gaataagctc accctgtgta gttcttgcta 1260
aactctggct ggctggttca actcagctct tctggttcaa acccgtctcc aaactgactg 1320
attgaaacag gcctctcttg gcttggaaag tctgctctga actccagaac tgaacggtac 1380
tgactgcact gactcgactg aacgcaactg caccgagttg attgactcct tctcccttta 1440
ctgctcttaa gtaccctctc ttccctgtgc tgtcctcctg agtcatgctg ccaaatcttt 1500
ctctgattca tcacttcgcc cctcaattag actggcaatt tcaaacgtgg cacttagcat 1560
ttcagttgta gtcacttaat actgcattca gaacttgagt ctattgaatc cataatgtga 1620
aaccatgtct tcgtgactgt gacctcacta ctcagtattg tgtaaaagtt ttaggaactc 1680
tccaagtaag cacttggtat ttgctcattg atagaacaga aaaatgctgt gtagataata 1740
aataaacacg gctataagat caaaa 1765
<210> 12
<211> 1496
<212> DNA
<213> 褐家鼠
<220>
<221> misc_feature
<222> (893)..(893)
<223> n是a、c、g或t
<400> 12
accatggcgg acgcggagaa aaacgctgtt gcggagaaaa acgctgttgc ggaggaaaac 60
gccgttgcgg aggaaaacgc cgttgcggat aaaaacgcaa cgaaagaggt tctggctgag 120
gcagcaagcg ttctggaacc tgtaggattg ccggaagaag cagagctgcc tgccaagatc 180
atggaggaat ttatgaggaa ctctcggaag aaagacaagc tgctctgtag ccagcttcaa 240
gtagtgaact tcttacagac ttttctggcc caggaggata atactgacca gaacccagat 300
gctctggctt ctgaagatac aagtcgacaa aaggcaactg aaactaagga gcagtggaag 360
gagctgaagg caacatacat ggatcatgtg gacgtcatca aatgtgccct gtctgaggcc 420
ttgccccagg ttaaagaggc acacaggaag tacaccgagc ttcagaaggc ttttgagcaa 480
ctcgaggcta agaagcgagt ccttgaggag aaactgcagt tagctcagaa gcagtgggtg 540
ctgcagcaga agcgtttgca gaatctgaca aagatttctg ctgaggtcaa gagacgccgg 600
aagagagctc tggagaagct tgatggttct caccaggaac ttgaaacctt gaagcagcaa 660
gcaggacagg agcaggagaa gctgcagagg aaccagagct acctccagct gctgtgctcc 720
ctgcagaata agctggtcat ctctgagtcc aaggccgacg acaaagatgt caaagggccc 780
gcccttccac ccaagtctcc gtaaagatga aagcgagaag agagctgcgc tccagctgtg 840
ctgcttgggc tgagaccaga gtggttcctt cgctgttgta tccctaggcc tangcctgta 900
gccttgtaca atcttccaag cggactcagg tttggcatct cttggcttct cagtgaattg 960
ttctgtttca tttcttacca tatattctgg cttgttctgt cttcacctgg gtccaacttg 1020
ctgtttctgt aaaattgtgc cagtgaaatt gtcacgtgca tgcacgcagg cacacaggca 1080
cgcatgccac aaccaccctt ttctctcgct gatcttcagt agtctctcct ctggccctct 1140
ctctctctgt cttctctccc gaccagatgt gaaagtaact ttatgcaccc gatgtaattg 1200
ttgcctcgga ggctcattga tgaataagct caccctgtgt agttcttgct aaactctggc 1260
tggctggttc aactcagctc ttctggttca aacccgtctc caaactgact gattgaaaca 1320
ggcctctctt ggcttggaaa gtctgctctg aactccagaa ctgaacggta ctgactgcac 1380
tgactcgact gaacgcaact gcaccgagtt gattgactcc ttctcccttt actgctctta 1440
agtaccctct cttccctgtg ctgtcctcct gagtcatgct gccaaatcct cgtgcc 1496
<210> 13
<211> 2676
<212> DNA
<213> 小家鼠
<400> 13
aaaggcgtgg tgagcgacag aacgatggcg gacgcggaga aaaacgctgt tgcggagaaa 60
aacaacgctg ttgcgacgaa agaggttctg gctgaggcag cagccattct agaacctgta 120
ggcttgcagg aagaagcaga gctgcctgcc aagatcatgg aggagtttat gaggaactcg 180
cggaagaaag acaaactgct ctgtagccag cttcaagtag tgaacttctt acagactttt 240
ctggctcagg aggacactga gcagagccct gatgctctgg cttctgaaga tgccagtcgg 300
caaaaggcaa ctgaaactaa ggagcagtgg aaggacatga aggccacata catggatcac 360
gtggatgtca taaaatgtgc cctgtctgag gccttacccc aggttaaaga ggctcacagg 420
aagtacacag agcttcagaa ggcttttgag caactcgagg ctaagaagcg agtccttgag 480
gagaaacttc agctggctca gaagcagtgg gtactgcaac agaagcgttt gcagaacctg 540
acaaagattt ctgcagaggt caagaggcgc cggaagaggg ctctggagaa gcttgacgga 600
tcccatcagg aactggaaac cttgaagcag caagcggggc aggaacagga gaagctgcag 660
aggaaccaga gctacctcca gctgctgtgt tcgctgcaga ataagctggt catctctgag 720
ggcaaggctg aggacaaaga tgtgaaaggg cgagccctta cagccaaatc caaatctcct 780
taaagggtga aaacattgat gggtgaaatt tgcctttttg caccgcattt atggatcatc 840
ttgaaaaaga aatgagtgct tccaaaccac tcagtgaagg aggagacgaa gcagctttgt 900
aaaccgcaaa gttaaatcca cctactgtac agctgtcctg caacgagagc attgagtgag 960
aagacagcag ggaaggaaga acattccagg ggaagtggca gttgccatgg ggtggtggtg 1020
gttatgaaaa tgcatgagta aaggaaaata attctgcact aagataaagc aaaaagccat 1080
agcgtgagga ctgagcccag ctaacaggat actggacatg agcctctctg agggagacat 1140
gtcagtgaga agctttgagt ctataaactg ataaggacca cattgacttc tctgtacaga 1200
ttagaccagg gatgataggt ttgaaataca gatatttaga atttatggtt gtattaacaa 1260
gattgaaaga tgactaagat ctgggttagg aattgttggc agaaacgtgg taaatcttgt 1320
ggttattgga tagatttagg ctgttttact tataccattg attggacgtt aagtgtttga 1380
actatatatt gggggaattc caaagtttct ttattctgaa ctggtaggat ccagttctgt 1440
gctgacataa agaattgaca gggctggacc ttaaccaaga aacagcttat ggtaggtgta 1500
caattgagat ttgtccaagt ggtacacttg accactgcat tcatgtgtct aaggaccatt 1560
gagcagacgg gaattatgca gcttcactcc atctagggct gagatggcta agaacacaaa 1620
agtatggtaa caactagaga taggctgaca cggtcagctt caacacctgt tatattatgc 1680
atgtttgtat tttgaaaggg acaaagaaga acactggttt ggcctggaac accttttcta 1740
ctgagaatga gaagtggcct gatatactta tagcttgaca agtgagatgg tttgatgatg 1800
tcttcaagag ctaaggagaa gggactgaaa gaaatttagt taagattgaa agctggttgt 1860
gaagcctgtt agcagatctt caggatggac gtagtgagat gcagcaaacc tgttctttgc 1920
ctgaagaacc tgcaacaaga ctttgtggcc tggattgttg acccattgca tggatatgga 1980
ctttctggga aaccttagat tgttggaaac atttatggga ataggaatct ttcattaaat 2040
acctcaattt tctttgttgt tgatgttgtt gttatagcac aatctaccgt attctgcctg 2100
atttaagata aagagcataa aaatagtgct agcttgtgag agttagcctg ccaaggactg 2160
tgagggctag atagtgagag gttggaattg agccaagaca cactgatgat aaaataggtg 2220
gaggagtagt gaagatagtt gctgaagtat gccaggcttt agttttattt agaaaaaacc 2280
ataagccttt attacatttc tgtttgataa ttatctgagc ccccaaactt ctcctcaaat 2340
agtctgtttt aaaagtacaa tttatttact tccatttatc tgaagatatg tgccttccat 2400
ttctaatttg aaagtgctca gagtaaatct taggataggt tagttaacat cagctgatgt 2460
ctttgtctac ttttgagtct gaggacacca gtgatactta attgggtctt actctgtgct 2520
ttcattttta cttgactatt gttttaaagc ctcatttcca aacaaagtca caaagagcca 2580
ctgaaggcta gatttttgta actattaaac agtaaaaagt atgctacatg tataagatgt 2640
ataaatactt atttaagaat tatataagag tattct 2676
<210> 14
<211> 1770
<212> DNA
<213> 小家鼠
<400> 14
cgatggcgga cgcggagaaa aacgctgttg cggagaaaaa caacgctgtt gcgacgaaag 60
aggttctggc tgaggcagca gccattctag aacctgtagg cttgcaggaa gaagcagagc 120
tgcctgccaa gatcatggag gagtttatga ggaactcgcg gaagaaagac aaactgctct 180
gtagccagct tcaagtagtg aacttcttac agacttttct ggctcaggag gacactgagc 240
agagccctga tgctctggct tctgaagatg ccagtcggca aaaggcaact gaaactaagg 300
agcagtggaa ggacatgaag gccacataca tggatcacgt ggatgtcata aaatgtgccc 360
tgtctgaggc cttaccccag gttaaagagg ctcacaggaa gtacacagag cttcagaagg 420
cttttgagca actcgaggct aagaagcgag tccttgagga gaaacttcag ctggctcaga 480
agcagtgggt actgcaacag aagcgtttgc agaacctgac aaagatttct gcagaggtca 540
agaggcgccg gaagagggct ctggagaagc ttgacggatc ccatcaggaa ctggaaacct 600
tgaagcagca agcggggcag gaacaggaga agctgcagag gaaccagagc tacctccagc 660
tgctgtgttc gctgcagaat aagctggtca tctctgaggg caaggctgag gacaaagatg 720
tgaaagggcg agcccttaca gccaaatcca aatctcctta aagatgaaag gatgagaaga 780
gagccgtatt cataccctgc ttgggctgag accagattgg ttccttcact gttgtatctc 840
taggcctaag cctggaagtt tgttgcctct gtacaatcta attctccaag ctgattcaat 900
ctggcatctc ttggcttttc agtgaactgt tgtgttttgt ctcatgctaa ctttgacagt 960
atattctggc ttgttctgtc ttcacctgtg tctaacttgc tgtccttgca acctgtctct 1020
gtaaaagtgt accagtgaaa ctcacacgca tgcatgcacg cacacaggca cgcatgccac 1080
aaccaccctt ttctctcgct gatcttcagt agtctctcct cttgtcctct ctttttcttt 1140
gtcttctctc cctaccagat gtgaaagcaa ctttatgcgc ctgctgtaat tgttgtctga 1200
ggattactgc gagtaagctc accctttgta gttactaaac tggccggctg gctgggtcag 1260
ctccgctgta ctggttcata acccggcttc aagttgactg attcaaaggg gcctctcttg 1320
gcttctgact gaactgctct gcttggaaag tctgatggac ttcaggaaca gaactgtact 1380
gactgccctg actcagctga actcaactac accaaattca ttggttctct ctgctgtact 1440
gctcttaggt agcctctctc ctgtgctgtc ctcctgagtc gtgctgtcaa atctctctct 1500
gattcatcac tttgcccctc aattagactg gcagtttcaa acacggcact taacatttca 1560
gttgtagtca cttgatactg cattccgaac ttgagtctat tgaatccaga atgtgaatcc 1620
atgcctttgt gactgtgacc tcactctctt cagtattgtg taaaagtttt aggaactctc 1680
caagtaaata cttggtaatt gctcattgat agaacagaaa aatgctgtgt agataataaa 1740
taaacatata actataagat taaaaaaaaa 1770
<210> 15
<211> 2677
<212> DNA
<213> 小家鼠
<400> 15
gaaaggcgtg gtgagcgaca gaacgatggc ggacgcggag aaaaacgctg ttgcggagaa 60
aaacaacgct gttgcgacga aagaggttct ggctgaggca gcagccattc tagaacctgt 120
aggcttgcag gaagaagcag agctgcctgc caagatcatg gaggagttta tgaggaactc 180
gcggaagaaa gacaaactgc tctgtagcca gcttcaagta gtgaacttct tacagacttt 240
tctggctcag gaggacactg agcagagccc tgatgctctg gcttctgaag atgccagtcg 300
gcaaaaggca actgaaacta aggagcagtg gaaggacatg aaggccacat acatggatca 360
cgtggatgtc ataaaatgtg ccctgtctga ggccttaccc caggttaaag aggctcacag 420
gaagtacaca gagcttcaga aggcttttga gcaactcgag gctaagaagc gagtccttga 480
ggagaaactt cagctggctc agaagcagtg ggtactgcaa cagaagcgtt tgcagaacct 540
gacaaagatt tctgcagagg tcaagaggcg ccggaagagg gctctggaga agcttgacgg 600
atcccatcag gaactggaaa ccttgaagca gcaagcgggg caggaacagg agaagctgca 660
gaggaaccag agctacctcc agctgctgtg ttcgctgcag aataagctgg tcatctctga 720
gggcaaggct gaggacaaag atgtgaaagg gcgagccctt acagccaaat ccaaatctcc 780
ttaaagggtg aaaacattga tgggtgaaat ttgccttttt gcaccgcatt tatggatcat 840
cttgaaaaag aaatgagtgc ttccaaacca ctcagtgaag gaggagacga agcagctttg 900
taaaccgcaa agttaaatcc acctactgta cagctgtcct gcaacgagag cattgagtga 960
gaagacagca gggaaggaag aacattccag gggaagtggc agttgccatg gggtggtggt 1020
ggttatgaaa atgcatgagt aaaggaaaat aattctgcac taagataaag caaaaagcca 1080
tagcgtgagg actgagccca gctaacagga tactggacat gagcctctct gagggagaca 1140
tgtcagtgag aagctttgag tctataaact gataaggacc acattgactt ctctgtacag 1200
attagaccag ggatgatagg tttgaaatac agatatttag aatttatggt tgtattaaca 1260
agattgaaag atgactaaga tctgggttag gaattgttgg cagaaacgtg gtaaatcttg 1320
tggttattgg atagatttag gctgttttac ttataccatt gattggacgt taagtgtttg 1380
aactatatat tgggggaatt ccaaagtttc tttattctga actggtagga tccagttctg 1440
tgctgacata aagaattgac agggctggac cttaaccaag aaacagctta tggtaggtgt 1500
acaattgaga tttgtccaag tggtacactt gaccactgca ttcatgtgtc taaggaccat 1560
tgagcagacg ggaattatgc agcttcactc catctagggc tgagatggct aagaacacaa 1620
aagtatggta acaactagag ataggctgac acggtcagct tcaacacctg ttatattatg 1680
catgtttgta ttttgaaagg gacaaagaag aacactggtt tggcctggaa caccttttct 1740
actgagaatg agaagtggcc tgatatactt atagcttgac aagtgagatg gtttgatgat 1800
gtcttcaaga gctaaggaga agggactgaa agaaatttag ttaagattga aagctggttg 1860
tgaagcctgt tagcagatct tcaggatgga cgtagtgaga tgcagcaaac ctgttctttg 1920
cctgaagaac ctgcaacaag actttgtggc ctggattgtt gacccattgc atggatatgg 1980
actttctggg aaaccttaga ttgttggaaa catttatggg aataggaatc tttcattaaa 2040
tacctcaatt ttctttgttg ttgatgttgt tgttatagca caatctaccg tattctgcct 2100
gatttaagat aaagagcata aaaatagtgc tagcttgtga gagttagcct gccaaggact 2160
gtgagggcta gatagtgaga ggttggaatt gagccaagac acactgatga taaaataggt 2220
ggaggagtag tgaagatagt tgctgaagta tgccaggctt tagttttatt tagaaaaaac 2280
cataagcctt tattacattt ctgtttgata attatctgag cccccaaact tctcctcaaa 2340
tagtctgttt taaaagtaca atttatttac ttccatttat ctgaagatat gtgccttcca 2400
tttctaattt gaaagtgctc agagtaaatc ttaggatagg ttagttaaca tcagctgatg 2460
tctttgtcta cttttgagtc tgaggacacc agtgatactt aattgggtct tactctgtgc 2520
tttcattttt acttgactat tgttttaaag cctcatttcc aaacaaagtc acaaagagcc 2580
actgaaggct agatttttgt aactattaaa cagtaaaaag tatgctacat gtataagatg 2640
tataaatact tatttaagaa ttatataaga gtattct 2677
<210> 16
<211> 1805
<212> DNA
<213> 小家鼠
<400> 16
gaatccaaag gcgtggtgag cgacagaacg atggcggacg cggagaaaaa cgctgttgcg 60
gagaaaaaca acgctgttgc gacgaaagag gttctggctg aggcagcagc cattctagaa 120
cctgtaggct tgcaggaaga agcagagctg cctgccaaga tcatggagga gtttatgagg 180
aactcgcgga agaaagacaa actgctctgt agccagcttc aagtagtgaa cttcttacag 240
acttttctgg ctcaggagga cactgagcag agccctgatg ctctggcttc tgaagatgcc 300
agtcggcaaa aggcaactga aactaaggag cagtggaagg acatgaaggc cacatacatg 360
gatcacgtgg atgtcataaa atgtgccctg tctgaggcct taccccaggt taaagaggct 420
cacaggaagt acacagagct tcagaaggct tttgagcaac tcgaggctaa gaagcgagtc 480
cttgaggaga aacttcagct ggctcagaag cagtgggtac tgcaacagaa gcgtttgcag 540
aacctgacaa agatttctgc agaggtcaag aggcgccgga agagggctct ggagaagctt 600
gacggatccc atcaggaact ggaaaccttg aagcagcaag cggggcagga acaggagaag 660
ctgcagagga accagagcta cctccagctg ctgtgttcgc tgcagaataa gctggtcatc 720
tctgagggca aggctgagga caaagatgtg aaagggcgag cccttacagc caaatccaaa 780
tctccttaaa gatgaaagga tgagaagaga gccgtattca taccctgctt gggctgagac 840
cagattggtt ccttcactgt tgtatctcta ggcctaagcc tggaagtttg ttgcctctgt 900
acaatctaat tctccaagct gattcaatct ggcatctctt ggcttttcag tgaactgttg 960
tgttttgtct catgctaact ttgacagtat attctggctt gttctgtctt cacctgtgtc 1020
taacttgctg tccttgcaac ctgtctctgt aaaagtgtac cagtgaaact cacacgcatg 1080
catgcacgca cacaggcacg catgccacaa ccaccctttt ctctcgctga tcttcagtag 1140
tctctcctct tgtcctctct ttttctttgt cttctctccc taccagatgt gaaagcaact 1200
ttatgcgcct gctgtaattg ttgtctgagg attactgcga gtaagctcac cctttgtagt 1260
tactaaactg gccggctggc tgggtcagct ccgctgtact ggttcataac ccggcttcaa 1320
gttgactgat tcaaaggggc ctctcttggc ttctgactga actgctctgc ttggaaagtc 1380
tgatggactt caggaacaga actgtactga ctgccctgac tcagctgaac tcaactacac 1440
caaattcatt ggttctctct gctgtactgc tcttaggtag cctctctcct gtgctgtcct 1500
cctgagtcgt gctgtcaaat ctctctctga ttcatcactt tgcccctcaa ttagactggc 1560
agtttcaaac acggcactta acatttcagt tgtagtcact tgatactgca ttccgaactt 1620
gagtctattg aatccagaat gtgaatccat gcctttgtga ctgtgacctc actctcttca 1680
gtattgtgta aaagttttag gaactctcca agtaaatact tggtaattgc tcattgatag 1740
aacagaaaaa tgctgtgtag ataataaata aacatataac tataagatta aaaaaaaaaa 1800
aaaag 1805
<210> 17
<211> 1607
<212> DNA
<213> 牛
<400> 17
gagttccaga gtagagctgg agcgcagcct ggagcaaaat gggggctgca gagtctgaag 60
tggagactgc agcccgagag gtcctggcca aggtagcaga catccaggag cctgttggtt 120
ttcaggagga agctgaactg cctgcccaga tcctggctga gtttgtgatg gactctcgga 180
agaaagacaa gctcctttgc agccagcttc aagtagtaga cttcctgcag aatttcttgg 240
ttcaggaagg cactgcccag gaccagaacc ccttggcttc tgaagacaca agccggcaga 300
aggcacttga agccaaagag caatggaaag agctgaaggc cacatatcaa gaacatgtgg 360
aggttatcac aaattccctg accgaggcac tgcccaaggt ggaggaggcc caaataaagc 420
aggcacagct ccaggaggcc cttaaacagc tccaggccaa gaagcaaatg gccatggaaa 480
aactcagaat agcccagaag cagtggcagc tggaacagga gaagcatttg cagaatctgg 540
cggaggcttc atcagaagtg agggagcgtc agacaggagc tcaacaggaa cttcaacgac 600
tatatcagga acttggaacc ctgaagcagc aggcagggca ggagaaggac aagctgcaga 660
ggcaccagac cttcctccag ctgctataca ccctgcaggg taagcagcta ttcaatgagg 720
cagaggcaga gataccacag gagttggatc ttcctaagga taagctccaa caggtgaccc 780
agccccagga acagaacact caggacacca tgggaagaga ggctgacaac ccacagcctg 840
ttggagatgc aggcttacca tggcttcctg gcagacagca acataaggaa gaatcctaga 900
gcaggccctg atttgctatg aactgaagtt gcagaagtgg acttaactga ccagtcactg 960
gccacttgga gcataatgat aatgaacaag tcaataggat ggtttcagta tgtgtgacaa 1020
cagggttgca aactgaaaca gtaataaaga gcaatagtga aaaagtatag agacccgccc 1080
ccccaacctc tatattggtc tatgatatgt gagttggtat ttctatttgt gctggtatgt 1140
ttgtgtttct atatttttgt ttgttgcttt cattctccat tcctctatgt gtctcactga 1200
atgtatgaac agtgggatca ctactgtgtt tgaggaagtg attacatccc tgatctgtag 1260
cctattctag gatgtcctaa tgttatattc ctgatacatt ttttgtgttc tactgttttt 1320
tttccttgac tcatcctttc ggattgtcat tcatcttcaa atattcgcat gctgaaagac 1380
tggcttttgt gattctctgt tgtatgtttt gttctggttc attgatttgt agtagtatct 1440
tgatcatttt ctggcttctg tttttaggtc aagaatatgt ttttttttgg taaacttttt 1500
atcaggtaat aaacttctgt atttggacct ttatttgttt tctcaaataa acatttaaag 1560
ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa gaaaaaaaaa aaaataa 1607
<210> 18
<211> 1607
<212> DNA
<213> 牛
<400> 18
gagttccaga gtagagctgg agcgcagcct ggagcaaaat gggggctgca gagtctgaag 60
tggagactgc agcccgagag gtcctggcca aggtagcaga catccaggag cctgttggtt 120
ttcaggagga agctgaactg cctgcccaga tcctggctga gtttgtgatg gactctcgga 180
agaaagacaa gctcctttgc agccagcttc aagtagtaga cttcctgcag aatttcttgg 240
ttcaggaagg cactgcccag gaccagaacc ccttggcttc tgaagacaca agccggcaga 300
aggcacttga agccaaagag caatggaaag agctgaaggc cacatatcaa gaacatgtgg 360
aggttatcac aaattccctg accgaggcac tgcccaaggt ggaggaggcc caaataaagc 420
aggcacagct ccaggaggcc cttaaacagc tccaggccaa gaagcaaatg gccatggaaa 480
aactcagaat agcccagaag cagtggcagc tggaacagga gaagcatttg cagaatctgg 540
cggaggcttc atcagaagtg agggagcgtc agacaggagc tcaacaggaa cttcaacgac 600
tatatcagga acttggaacc ctgaagcagc aggcagggca ggagaaggac aagctgcaga 660
ggcaccagac cttcctccag ctgctataca ccctgcaggg taagcagcta ttcaatgagg 720
cagaggcaga gataccacag gagttggatc ttcctaagga taagctccaa caggtgaccc 780
agccccagga acagaacact caggacacca tgggaagaga ggctgacaac ccacagcctg 840
ttggagatgc aggcttacca tggcttcctg gcagacagca acataaggaa gaatcctaga 900
gcaggccctg atttgctatg aactgaagtt gcagaagtgg acttaactga ccagtcactg 960
gccacttgga gcataatgat aatgaacaag tcaataggat ggtttcagta tgtgtgacaa 1020
cagggttgca aactgaaaca gtaataaaga gcaatagtga aaaagtatag agacccgccc 1080
ccccaacctc tatattggtc tatgatatgt gagttggtat ttctatttgt gctggtatgt 1140
ttgtgtttct atatttttgt ttgttgcttt cattctccat tcctctatgt gtctcactga 1200
atgtatgaac agtgggatca ctactgtgtt tgaggaagtg attacatccc tgatctgtag 1260
cctattctag gatgtcctaa tgttatattc ctgatacatt ttttgtgttc tactgttttt 1320
tttccttgac tcatcctttc ggattgtcat tcatcttcaa atattcgcat gctgaaagac 1380
tggcttttgt gattctctgt tgtatgtttt gttctggttc attgatttgt agtagtatct 1440
tgatcatttt ctggcttctg tttttaggtc aagaatatgt ttttttttgg taaacttttt 1500
atcaggtaat aaacttctgt atttggacct ttatttgttt tctcaaataa acatttaaag 1560
ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa gaaaaaaaaa aaaataa 1607
<210> 19
<211> 1708
<212> DNA
<213> 牛
<400> 19
agtcccagag tagagctgga gcgcagcctg gagcaaaatg ggggctgcag agtctgaagt 60
ggagactgca gcccgagagg tcctggccaa ggtagcagac atcctggagc ctgttggttt 120
tcaggaggaa gctgaactgc ctgcccagat cctggctgag tttgtgatgg actctcggaa 180
gaaagacaag ctcctttgca gccagcttca agtagtagac ttcctgcaga atttcttggt 240
tcaggaaggc actgcccagg accagaaccc cttggcttct gaagacacaa gccggcagaa 300
ggcacttgaa gccaaagagc aatggaaaga gctgaaggcc acatatcaag agcatgtgga 360
ggttatcaca aattccctga ccgaggcact gcccaaggtg gaggaggccc aaataaagca 420
ggcacagctc caggaggccc ttaaacagct ccaggccaag aagcaaatgg ccatggaaaa 480
actcagaata gcccagaagc agtggcagct ggaacaggag aagcatttgc agaatctggc 540
agaggcttcg tcagaaggta agcagctatt caatgaagca gaggcagaga taccacagga 600
gttggatctt cctaaggata agctccagca ggtgacccag ccccaggaac agaacactca 660
ggacaccatg ggaagagagg ctgacaaccc acagcctgtt ggagatgcag gcttaccatg 720
gcttcctggc agacagcaac ataaggaaga atcctagagc aggccctgat ttgctatgaa 780
ctgaagttgc agaagtggac ttaactgact agtcactggc cacttggagc ataatgataa 840
tgaacaagtc aataggatga tttcagcgtg tgtgacaaca gggttgcaaa ctgaaacagt 900
aataaagagc aatagtgaaa aagtatagag acccgccccc ccaacctcta tattggccta 960
tgatatgtgc attggtattt ctatttgtgc tggtatgttt gtgtttctat atttttgttt 1020
gttgctttca ttctccattc ctctatgtgt ctcactgaat gtatgaacag tgggatcact 1080
actgtgtttg aggaagtgat tacatccctg atctgtagcc tattctagga tgtcctaatg 1140
ttatattcct gatacatttt ttgtgttcta ctgttttttt ttccttgact catcctttcg 1200
gattgtcatt catcttcaaa tattcgaatg ctgaaagact ggcttttgtg attctctatt 1260
gtatgttttg ttctggttca ttgatttgta gtagtatctt gatcattttc tggcttctgt 1320
ttttaggtca agaatatgtt tttttttggt aaacttttta tcaggtaata aacttgtgta 1380
tttggacctt tatttgtttt ctcaaataaa catttaaagt tattttcttc tggcttccta 1440
ttagtatttt cacaatcatt caattcgtag atttttctat taaaattatt tctttgattc 1500
atgagtttct tagaaaaata attttcaaat tttttactct atgtgagagg ataatctttc 1560
taggtttatt ctaatttagt cagaaaatgt caaatctata ataaaaactt tgaaatttag 1620
tgacggaagc agttgtagcc ttgaatgtga tttctttaat gtttcatgtt gatttttttt 1680
tctttttttt tcatgttgat tttttaaa 1708
<210> 20
<211> 2069
<212> DNA
<213> 食蟹猴
<400> 20
attgtgggaa ggcggctgaa cgcggcccct agaaggatgg aggcggcgga gacagaggcg 60
gaagctgcag ccctagaggt cctggctgag gtggcaggca tcctggaacc tgtaggcttg 120
caggaggagg cagaactgcc agccaagatc ctggttgagt ttgtggtggt atgtacaaga 180
tgagagcgag cctttcagaa gccagggtct ggtcctggct cctcttattg agatacaggg 240
cagcattggc agagagcaga ctttaaggaa acctgtaagg aggtaaggac gttccctgtc 300
tctgccctcc ctctgagcag gactcccaga agaaagacaa gctgctctgc agccagcttc 360
aggtagtgga cttcctgcag aacatcctgg ctcaggagga cactgctaag ggtctggacc 420
ccttggcttc tgaagacacc agccgtgagt aggcagggga ttggagtagc atctggcctg 480
agtggggaac gaaggaggat ttcagatagg tctcccattt ggctgatggg aaggaggccc 540
agtgttgcaa ggaggcaggc tagcaggcca ccctcactca tgttctcatt cctggtggct 600
catctcagga cagaaggcaa ttgcagctaa ggaacaatgg aaagagctga aggccaccta 660
cagggagcac gtagaggcca tcaaaattgg cctcaccaag gccctgactc agatggagga 720
agcccagagg aagcggacac aactccagga agcctttgag cagctccagg ccaagaaaca 780
agtggccatg gagaaacgca gagcagccca gaaccagtgg caactacaac aggagaagca 840
tctgcagcat ctggcaaaag tttctgcaga gggtaagctg ttgttccctg aggctgaagc 900
tgaggcagag aatcttccag atgataaacc ccagcagctg actcgacccc aggagcagag 960
tacaggagac actatgggga gagatgctgg tgtgtccttc aaggctgtca gcctacaacc 1020
tgctggagat gcaaatttgc catgacttcc tggaggacaa cagcatggag aaagatccta 1080
gaataggtca gacccaactt aggccttggt gtccctggat gcaagtgtgg aaagagggaa 1140
agcctctctg tgcatctgag ctctgctacc catggagcag atggatggtg ggaacaggaa 1200
agagcttatg ttacagttta acacctcatt cccttgctca gcccacccag agctaacccc 1260
tgtcttcttc cccaggcctc tgacttccct caccaccccc aaccatcatt ccaggaaaga 1320
ctgtgaactc ctgttgctgt tcagcctgat tgctgactac atcccagcaa gctctggcat 1380
ctgtggatta aaagccctgg atctctctca gttgcgtatt tgttcatctt catatgctgg 1440
caggaaaaac tattagtaca gatactcaga agccaataac atgacaggag ctgggactgg 1500
tttgaacaca gggtgtgcag atggggaggg ggtactggcc ttgggcctca ggggttgctt 1560
ccccctatga tgcagacatg ctgaatttaa ttcaaggagg aggagattgc tttaggcagg 1620
tggttatatg tgggaagata atttattcac taatccaaat tttattcatg gatccaaatg 1680
tttgttgagt cctttctttg tgctaaggtt cttgctgtga accagagctg taacagtgaa 1740
ttcatctgac tgttttaggt tgtatagcct agtgttaaca ttcttagtgt ctttttgtgc 1800
cttaaaacat ttcttgatca ctggtttcag atgttcattt ataatattct tttcaaagat 1860
tcagagattg gcttttgtca tccactattg tatgttttgt ttcattgacc tctagtgata 1920
ccttgatcgt ttcctacttt ctgttttcag atggagaaga tgtacctttt ttgtaaactc 1980
ttattttgta aactcttatt tttatcagat gatcaactca tgtacttgaa tatttgtttt 2040
ctcaaataaa tatttaaggc taaaaaaaa 2069
<210> 21
<211> 2070
<212> DNA
<213> 食蟹猴
<400> 21
attgtgggaa ggcggctgaa cgcggcccct agaaggatgg aggcggcgga gacagaggcg 60
gaagctgcag ccctagaggt cctggctgag gtggcaggca tcctggaacc tgtaggcttg 120
caggaggagg cagaactgcc agccaagatc ctggttgagt ttgtggtggt atgtacaaga 180
tgagagcgag cctttcagaa gccagggtct ggtcctggct cctcttattg agatacaggg 240
cagcattggc agagagcaga ctttaaggaa acctgtaagg aggtaaggac gttccctgtc 300
tctgccctcc ctctgagcag gactcccaga agaaagacaa gctgctctgc agccagcttc 360
aggtagtgga cttcctgcag aacatcctgg ctcaggagga cactgctaag ggtctggacc 420
ccttggcttc tgaagacacc agccgtgagt aggcagggga ttggagtagc atctggcctg 480
agtggggaac gaaggaggat ttcagatagg tctcccattt ggctgatggg aaggaggccc 540
agtgttgcaa ggaggcaggc tagcaggcca ccctcactca tgttctcatt cctggtggct 600
catctcagga cagaaggcaa ttgcagctaa ggaacaatgg aaagagctga aggccaccta 660
cagggagcac gtagaggcca tcaaaattgg cctcaccaag gccctgactc agatggagga 720
agcccagagg aagcggacac aactccagga agcctttgag cagctccagg ccaagaaaca 780
agtggccatg gagaaacgca gagcagccca gaaccagtgg caactacaac aggagaagca 840
tctgcagcat ctggcaaaag tttctgcaga gggtaagctg ttgttccctg aggctgaagc 900
tgaggcagag aatcttccag atgataaacc ccagcagctg actcgacccc aggagcagag 960
tacaggagac actatgggga gagatgctgg tgtgtccttc aaggctgtca gcctacaacc 1020
tgctggagat gcaaatttgc catgacttcc tggaggacaa cagcatggag aaagatccta 1080
gaataggtca gacccaactt aggccttggt gtccctggat gcaagtgtgg aaagagggaa 1140
agcctctctg tgcatctgag ctctgctacc catggagcag atggatggtg ggaacaggaa 1200
agagcttatg ttacagttta acacctcatt cccttgctca gcccacccag agctaacccc 1260
tgtcttcttc cccaggcctc tgacttccct caccaccccc aaccatcatt ccaggaaaga 1320
ctgtgaactc ctgttgctgt tcagcctgat tgctgactac atcccagcaa gctctggcat 1380
ctgtggatta aaagccctgg atctctctca gttgcgtatt tgttcatctt catatgctgg 1440
caggaaaaac tattagtaca gatactcaga agccaataac atgacaggag ctgggactgg 1500
tttgaacaca gggtgtgcag atggggaggg ggtactggcc ttgggcctca ggggttgctt 1560
ccccctatga tgcagacatg ctgaatttaa ttcaaggagg aggagattgc tttaggcagg 1620
tggttatatg tgggaagata atttattcac taatccaaat tttattcatg gatccaaatg 1680
tttgttgagt cctttctttg tgctaaggtt cttgctgtga accagagctg taacagtgaa 1740
ttcatctgac tgttttaggt tgtatagcct agtgttaaca ttcttagtgt ctttttgtgc 1800
cttaaaacat ttcttgatca ctggtttcag atgttcattt ataatattct tttcaaagat 1860
tcagagattg gcttttgtca tccactattg tatgttttgt ttcattgacc tctagtgata 1920
ccttgatcgt ttcctacttt ctgttttcag atggagaaga tgtacctttt ttgtaaactc 1980
ttattttgta aactcttatt tttatcagat gatcaactca tgtacttgaa tatttgtttt 2040
ctcaaataaa tatttaaggc taaaaaaaaa 2070
<210> 22
<211> 1890
<212> DNA
<213> 普通猕猴
<400> 22
gattgtggga aggcggctga atgcggcgcc tagaaggatg gaggcggcgg agacagaggc 60
ggaagctgca gccctagagg tcctggctga ggtggcgggc atcctggaac ctgtaggctt 120
gcaggaggag gcagaactgc cagccaagat cctggttgag tttgtggtgg actcccagaa 180
gaaagacaag ctgctctgca gccagcttca ggtagtggac ttcctgcaga acatcctggc 240
tcaggaggac actgctaagg gtctggaccc cttggcttct gaagacacca gccgacagaa 300
ggcaattgca gctaaggaac aatggaaaga gctgaaggcc acctacaggg agcacgtaga 360
ggccatcaaa attggcctca ccaaggccct gactcagatg gaggaagccc agaggaagcg 420
gacacaactc caggaagcct ttgagcagct ccaggccaag aaacaagtgg ccatggagaa 480
acgcagagca gcccagaacc agtggcaact acaacaggag aagcatctgc agcatctggc 540
aaaagtttct gcagaggtga gggagcgtaa gacagggact cagcaggagc ttgagggggt 600
gtttcagaaa cttggaaacc tgaagcagca ggcagaacag gagcaggaca agctgcagag 660
gtaccagact ttcctccagc ttctgtatac cctgcagggt aagctgttgt tccctgaggc 720
tgaagctgag gcagagaatc ttccagatga taaaccccag cagctgactc gaccccagga 780
gcaaagtaca ggagacacta tggggagaga tgctggtgtg tccttcaagg ctgtcagcct 840
acaacctgct ggagatgcaa atttgccatg acttcctgga ggacaacagc atggagaaag 900
atcctagaat aggtcagacc caacttaggc cttggtgtcc ctggatgcag tatggaaaga 960
gggaaagcct ctctgtgcat ctgagctctg ctacccatgg agcagatgga tggtgggaac 1020
aggaaagagc ttatgttaca gtttaacacc tcattccctt gctcagccca cccagagcta 1080
acccctgtct tcttccccag gcctctgact tccctcacca cccccaacca tcattccagg 1140
aaagactgtg aactcctgag ttcagcctga ttgctgacta catcccagca agctctggca 1200
tctgtggatt aaaagccctg gatctctctc agttgcgtac ttgttcatct tcatatgctg 1260
gcaggaagaa ctattagtac agatactcag aagccaataa catgacagga gctgggactg 1320
gtttgaacac agggtgtgca gatagggagg gggtactggc cttgggcctc aggggttgct 1380
tcctccaatg atgcagacat gctgaattta attcaaggag gaggagattg ctttaggcag 1440
gtggttatat gtgggaagat aatttattca ctaatccaaa ttttattcat ggatccaaat 1500
gtttgttgag tcctttcttt gtgctaaggt tcttgctgtg aaccagagct gtaacagtga 1560
gctcatctga ctgttttagg ttgtatagcc tagtgttaac attcttagtg tctttttgtg 1620
ccttaaaaca ttgcttgatc actggtttca gatgttcatt tataatattc ttttcaaaga 1680
ttcagagatt ggcttttgtc atccactatt gtatgttttg tttcattgac ctctagtgat 1740
accttgatcg tttcctactt tctgttttca gatggagaag atgtaccttt tttgtaaact 1800
cttattttgt aaactcttat ttttatcaga tgatcacatc atgtacttga atatttgttt 1860
tctcaaataa atatttaagg ctatacattt 1890
<210> 23
<211> 1017
<212> DNA
<213> 马
<400> 23
atggaggtgg cggagaccaa ggcggaggct gctgcgttag agaccctggc agaggtggca 60
gatatcctgg agccaagagg cctgcaggag gaggcagaag tgcctgccca gatcctggcc 120
gagtttgtga cggactcccg aaagaaagac aagctgctct gtagccagct tcaggtggta 180
gacttcctgc agaacttctt ggctcaggag gacactgccc agggcctgga ccccttggct 240
tctgaagaca cgagccggca gaaggcaatt gcagccaaag agcaatggaa ggagctgaag 300
gccacctacc aagagcatgt ggaagccatc acaagtgccc tgactcaggt cctgcccaag 360
gtggaggagg cccaaaggaa gcgggcacag ctccaggagg cccttgaaca actccaggcc 420
aagaagcaag tggccgcgga gaaactcaga gtagcgcaaa agcagtggca gctgcaacag 480
gagaagcatc tgcagcatct ggcagaggtt tctgcagagg tgagagagcg tcagacagga 540
atgaaacagg agcttgagcg gctgtatcag gaacttggaa ccctgaagca ggaggcaggg 600
caggagcgag aaaagctgca gaggcaccag accttcctcc agctgctcta caccctgcag 660
ggtaagctgc tactccctga ggcagaggca gagctaccac aagagcggga tcttcctgaa 720
cctaagtccc agcaggtgac ccagtcctgg gagctcaaca ctggggacac catggagaga 780
gtcggggatg tgtcgtccaa ggagctggat tttgaggact ccctcaagag tggcacaaga 840
gttggcagca gagtagaggg aggtgtgggc ttagcatctc gggtatgggg atgctcatgg 900
gtccagtggg gagatcctcg agcagggtac acccagaggt ctgtgggcaa gtctcctatt 960
gaagtcctga agcaggcagg aagaaacatg ttccttcagt tcactttaat attttga 1017
<210> 24
<211> 825
<212> DNA
<213> 鸭嘴兽
<400> 24
atggccatcc tcgcctccca ggatggacgg gaggaagccg aggctgaagt gccagccaag 60
ctccttgccg agtttgtgat ggactcgaga aagaaggaca agttactctg cagccagctc 120
catgtggtgc agttcttgca ggatttcctg gagcatatgg atgcagctcc cggattccat 180
atctcggagg aggagatccg aaaagaggcc aatgaagcca aacaaaagtg gaaggatctc 240
aaaggggact accaggagct ggtggagaaa atcgaggagg ccatgccacg ggttttgcag 300
caggtggaag ctctgcagaa gaaacgggaa ctcctggagg aagccctcag tgaataccaa 360
atgcagaaac actctactga ggagaaactg cgagctgttc aggaacagaa gcagcgggac 420
cagaactgca gggcgatggg ggtgatgaat gagttcccct tagactggaa acagcaggag 480
tggcagctgc gttacctgaa gccatcttgt gtgtgcaccc tcgctgtgca acccggtttg 540
ctgggttcat ccagccttga ggcggtgcgg ttgatctccg tggagggcct cccgaacccc 600
cccgacctgt tgctgtacaa gggcccggga ggggtcaggc cttgtgaccc gaacagcgca 660
gacccaaaat ccctaaacat ggggccctcg ctccgtgggg catatgggaa agagcaacaa 720
gagctagtga tatatggcgc caagcccagt gtagttttcc tcgggcagga ggactggcaa 780
aatggagtca caattgaggc ccctcgcgtc tccagctcag gatag 825
<210> 25
<211> 585
<212> DNA
<213> 短尾负鼠
<400> 25
atggcggccg acgtgactgc tcgagcggcg gcggtagcgg aggctctggc ttcagccgcc 60
gccacgttag aggcccccag cgttcaggag gatgtctcat ctgctctgct ggcagagttc 120
ttgaaggact cgaggaagaa ggagaagctg ctgtggggcc agctgcaggt ggtggatgcc 180
ctccagagct tcctggagca catggacgag gctgtgaacc ccgaagagga gatccgggca 240
gaagtcagcg cagcccatag gctgtggaaa gacctgaagg ccgagtacct aaagcagaca 300
gaagccgtgg aggccgccct gctgcaggcc ctggtacaac tggaggctgg ccagaggaag 360
cagcttttat tgagaagcac tctgcagcag atccagacca aagggcgggc cttggaggag 420
tggaggagca gggctcaaac ctggcgaagg caggagcagg aaaagcgcag gcaagagtta 480
accgctagag cccaggccca gagagaacgc ctggagaatg gtggccaaca gcaggagcag 540
gtgctgatgc tccagggtca agagacacag agtgcccaga ggtga 585
<210> 26
<211> 1205
<212> DNA
<213> 家犬
<400> 26
atggcggagg cggaggtcgg ggcgcgcgcc caggcgctcg aggccctggc cgcgctgggg 60
gacatcctgg agcccgtggg ccggcaagag gaggtagagc tgccagccca gatcctggcg 120
gagttcgtga tggactcccg gaagaaggac aagctgctct gcagtcagct tcaggtagta 180
gacttcctgc agaacttcct ggctcaggag ggcatcgtcc agggactaga ccccttggct 240
tctgaagaca cgagccggca gaaggcactt gcagtcaagg agcaatggaa agagctgaag 300
gccacttacc aggagcacgt ggaagccatc acaggtgccc tgacccaggc cctggccaag 360
acggaggagg cgcagagcaa gcgggtgcag ctccaggaag ccctggaaca gctccaggcc 420
aagaagcaag tggccatgga gagagcgaga acagcccaga agcagtggca gctgcaacag 480
gagaagcgtc tgcagcatct ggcagaggct tcagcagagg tgagacagcg gcagagagga 540
gctcagcagg agcttgagcg gctgcgtcag gaacttggag ccttacaaca gcaggccggg 600
cagaagcggg acaggcttca gaggcaccag accttcctcc ggctgctgca catactgcag 660
ggtgagccac tgctccccgg ggcagagacg gagcggcctc aagagctggg tattcctgag 720
gctaagcccc gggagcagaa cactggggat gctgtgggga aagacaggag tgtgccatcc 780
caggccgatg gcctgcagcc tgcccgaggg acaagctcac gttggtttcc tgagggacag 840
caacatggga aaggaacgta gagcaggact tgaggcctgt ttgtgttaca ctgccatgaa 900
gaaaatttgt gtacacaaaa ggagattctt ctttattttc agaaatcata gcatggaaaa 960
tacaacaaaa tatacttgag gaggcttcta aaagcaaacg gaattctata aacacggagt 1020
ttactttaga tgttaaaatg taatgttcat gaataatagc cacaaacgtc ttttgggcaa 1080
tacacttttc gttttgctta taaaattata cgtaactgaa gatggttaca ctttataaat 1140
gtctaatgtg cgttgctatt tatagatgct tcttttatta ataaaatgtg caatgccact 1200
gtctt 1205
<210> 27
<211> 885
<212> DNA
<213> 野猪
<400> 27
atggaggcgg cggagaccaa agcggaggct gcagcccgag aggccttggc caaggtggca 60
gacatcctgg aacctacagg tcttcaggag gaggcagaac tgcccgccca gatcctggct 120
gagtttgtga tggactctcg gaagaaagac aagctcctct gcagccagct acaagtagta 180
gacttcctac agaacttctt aatccaggaa gacactgcgc agggcttgga ccccttggct 240
tctgaagaca caagccgaaa gagggcaatt gaagccaaag agcaatggaa agagctgaag 300
gccacctacc aggagcatgt ggaggccatc acaagtgcct tgacccaggc actgcccaag 360
atggaggagg cccaaaagaa gcaagcacag ctacaagaga cccttgaaca actccaggcc 420
aagaagcaag tagctgtgga aaaactcaga atagcccaga agcagtggca gctgcaacag 480
gagaagcatc tgcagcacct gacaaaggtt tctgcagagg tgaaggaacg tcagatggga 540
actcagcagg agtttgaacg tctgtatcag gaacttgggg ccctgaagca acaggcaagg 600
caggagcagg acaaactgca gaggcatcag accttcctcc agctgcttta caccctacag 660
ggtaagctgc tgttctctga ggctgaggcg gaggcacaga taccacaaga actgaacctt 720
cctaaggata agcccctgca gctgacccaa ccccaggaac agaaccctca ggacatcatg 780
ggaagagatg gaagtgtgtc ctctaaggtc gacagccccc agcccattgg agatgcaagc 840
ttaccatggc ttcctggggc acagcaacat ggggaaggat cctag 885
<210> 28
<211> 4270
<212> DNA
<213> 人类
<400> 28
gagggccgct gtcactcagc cccgcgggcc aatagaaaag gggtgaaccc cgccttcttc 60
ctgagttgtg ctgcgggcat gcgcactggg cgtccccacg ccaccgccca tcagctgaga 120
attgcagctg agggctccgg ggtaggtggg tgacggcggt cggaggtgta ggagggagcc 180
gtggaggtcc aggtgactgc ttagaaaact gcacagcatc tgatgaaatt agcgaataag 240
aacatcaacc atgtcttaca ctccaggagt tggtggtgac cccgcccagt tggcccagag 300
gatctcttct aacatccaga agatcacaca gtgttctgtg gaaatacaaa gaactctgaa 360
tcaacttgga acacctcaag attcacctga attgaggcaa cagttgcaac agaagcagca 420
gtatactaac cagcttgcca aagaaacaga taagtacatt aaagagtttg gatctctgcc 480
caccaccccc agtgaacagc gtcaaaggaa aatacagaag gatcgcttag tggcagagtt 540
cacaacatca ctgacaaact tccagaaggt ccagaggcag gctgctgagc gagagaaaga 600
gtttgttgct cgagtaagag ccagttccag agtgtctggc agttttcctg aggacagctc 660
aaaagaaagg aatcttgtat cctgggaaag ccaaactcaa cctcaagtgc aggtgcagga 720
tgaagaaatt acagaggatg acctccgtct tattcatgag agagaatctt ctatcaggca 780
acttgaagct gatattatgg atattaatga aatatttaaa gatttgggaa tgatgattca 840
tgaacaagga gatgtaatag atagcataga agccaatgtg gaaaatgcag aggtgcacgt 900
tcagcaagca aatcagcagc tgtcaagggc agcagattat cagcgcaaat ccagaaaaac 960
cctgtgcatc atcattctta tccttgtcat tggagttgcg attatcagtc tcatcatatg 1020
gggattgaac cactgaagtt ataaaggagc acactgtcgc actacattgt ctaaattatg 1080
taggaagatt cctgtaatca tgttttttta attattattt taaagctatt gtataaagga 1140
tggttcccat actttgttat ttttattggg ggggttgggg tggttccttt ggattaaatc 1200
tgatattttc taatactgaa agattttcta aatgtcactg ctgacataac tcccttggtc 1260
ttcaatttaa tagttgttaa gtttttgccc acattgcata tgcctttcat ttataattta 1320
tttaccctgc ttgacttagt tttgggaatt cgtaaattta aaggtgtgtg tattctgttt 1380
gcatctccct gtcactgtga cacacctaga tgtgtgttac ttcaattaaa attctcaaat 1440
ttaattttga tttgcttcag cagggaaaat attctcaata atgtaaaata attaaggtct 1500
atacatgggt tgtatttttc tggttcacaa cagcacaaag tgtctttcat ttttttgttg 1560
gttttctttt aagatctttt ttaccctgaa gtcggtgaat acttttctag tttatttgat 1620
actctttctg tgtatatatt aagcttttgc tgtagattgc ctagtaaaat tactaaggat 1680
aggttgtttt tacatatggt ctatttaagt ctgatgttta cgggggaaag tgtagttact 1740
aaaaatgttt aacataattt ggaagaagag tatgaacaac caataccaat acctattgcg 1800
tttggattct taagacccca gtttgttatt ccactaaact agttatctta accatatcat 1860
ctggttttgt gggccattat ttaccttccc ttatgtctta tagaataatg gttaatattt 1920
ttaggtcaaa attacttttg gaaagtaact ttcccacaat taactgtttt tgagcacctg 1980
acaaaattta gtgtttacct tgcgtgccat tttgtgtcat ccttcattaa aaaagcaatt 2040
ggaggtttgc cagttatctc acttcccttt ttaaatcaat gttgttttaa tgcactaatc 2100
tgaattctgt aaagaggatt atcttagttt atactttgta ttttataatg ttcttgtata 2160
gcagctcggt actgaaggcg gtgtttaact tggcaagctc tgagacttca aatgggaaca 2220
aatagtaagt agctaagtaa accacatctt tgcaaccaaa ataaagatga gttaaaaggt 2280
atctggttag gcctatttca tgaggactat gctctggtgg gaccacaggt cacctgatac 2340
ttagtgctgt gctgcctgaa acctcagcat ggagacatca ccacatgcac tgtggccatt 2400
cagcatcttt ctggagcacc agttcactcc aggtttttat tttagggtgt catcgatttt 2460
acctactttg tcagactggt agaagttgct ttgcatatca gaaaaactcc atttttttcc 2520
acaaaaggga ttacagaaaa ctcttttgtg agtgagtgat tggaacttag agactcctgt 2580
tgccagaatc agactgccct agaacagaat ggacaatgca gggaggagaa ttcacacaaa 2640
cagcacctgt tctgaggcct gtgccagccc accaggcctg ctcaaatgtg gtctttactt 2700
caagtgcaca gaggcacatg aggtttctgg tgataaacca gcgtcttacc gctgttttaa 2760
agtcccatcc ccatggcttt cacaatcagt tccgtttttt ttgctgtact tgataaaatg 2820
tttattctca tacaggtcaa gtacatttac ttctattcac agtgagtacc caataacaac 2880
aaaagcgctt acaaatttgg ggggcgtgat tttagtacct ttatttgaag tgtaatcatt 2940
ttaaattatt attattttaa ctggggcagt tatcagtggt ttaaacagga actttagtgg 3000
cttcaatttg tttaagaaac atattaagtt tgagggaaaa atttcccatg aaatatttgg 3060
aacgtaagag tagtattgat tagagaaaat taaataagaa acatagtatg gtagccaaat 3120
tttttaaaaa atcttgaact tttctgtagg tcagttttag aactgctgtg aaaagtgaag 3180
gttgccctgt ggagattaaa attagagttg ttttcataac tgacagcatg gtgaatccat 3240
ttgagtcaaa gtgaagaatt tcctcatcaa gtgactatac atttgttttt gtgtgctcaa 3300
aagaaatact caaacacaga ctgatattaa ccagccaggt aaattgaacg acaatgtggc 3360
attaggtatt tggctgttta ttggtcgtta aatactatgg ttttgcaata tgattgatgg 3420
taaaagagtg atgtcatatt gatactagag tagcttgttt ttttagtagg tgtgggacca 3480
tctcttttac aagtgcaact cagtctagga cagccatgga tgcagtgtct ggagttggac 3540
cctctgagcc cgctggctgc cccagtagca tctgcattgg tgaccaagga cactgcactt 3600
tgaagaggtc gccactgggt tatttagtgt cttcactgct tttgttaaaa attgtaaaat 3660
tttgtacaca aaaagttgtg tttttgaata tcaattgttt agacacacct acaatgataa 3720
ataagtgcct ttaaaggccc ctctttccat gaaatacatc tgtggtttag caaggaaagt 3780
acaaaatagt ttatgtagtt ggtataattt ttatttgtgt cttcatgtag aaaaaatgaa 3840
tgtcataata aaatataaaa cttacgtaaa gaaaataaag tcattgtcca ccttaatagc 3900
taaggtccac aagggtaact tatgcagcat ttattttttt tgaaagtcaa aattgaattt 3960
atttctttca catggctggt ttgctgcaat atgaagtttc agaatgggct gaagtaagtt 4020
gattgaggga tttgagttga atgacatttt caagttcatt taaatatgat aaaaattcat 4080
tggtggtaaa taacatctgt ctttcctgga aaaaaaaaag ttgtgtattt tcatgattca 4140
gttaaaacaa aaaatgagcc tgtgaatccc aggccttttt agtcctccat aacatttgaa 4200
cagtttgact tgtcagcaaa gaaatacact tatcaaattt taaaccaatg ggagcctgaa 4260
agtgttacag 4270
<210> 29
<211> 860
<212> DNA
<213> 人类
<400> 29
gtcaacttag cgagcgcaac aggctgccgc tgaggagctg gagctggtgg ggactgggcc 60
gcaatggaca agctgaagaa ggtgctgagc gggcaggaca cggaggaccg gagcggcctg 120
tccgaggttg ttgaggcatc ttcattaagc tggagtacca ggataaaagg cttcattgcg 180
tgttttgcta taggaattct ctgctcactg ctgggtactg ttctgctgtg ggtgcccagg 240
aagggactac acctcttcgc agtgttttat acctttggta atatcgcatc aattgggagt 300
accatcttcc tcatgggacc agtgaaacag ctgaagcgaa tgtttgagcc tactcgtttg 360
attgcaacta tcatggtgct gttgtgtttt gcacttaccc tgtgttctgc cttttggtgg 420
cataacaagg gacttgcact tatcttctgc attttgcagt ctttggcatt gacgtggtac 480
agcctttcct tcataccatt tgcaagggat gctgtgaaga agtgttttgc cgtgtgtctt 540
gcataattca tggccagttt tatgaagctt tggaaggcac tatggacaga agctggtgga 600
cagttttgta actatcttcg aaacctctgt cttacagaca tgtgcctttt atcttgcagc 660
aatgtgttgc ttgtgattcg aacatttgag ggttactttt ggaagcaaca atacattctc 720
gaacctgaat gtcagtagca caggatgaga agtgggttct gtatcttgtg gagtggaatc 780
ttcctcatgt acctgtttcc tctctggatg ttgtcccact gaattcccat gaatacaaac 840
ctattcagca acagcaaaaa 860
<210> 30
<211> 2090
<212> DNA
<213> 人类
<400> 30
gccggcgccg ctgccactcc cgggagcatg aaggaccgaa cccaggagct ccgcacggcc 60
aaggacagcg atgatgatga tgatgtcgct gtcaccgtgg accgagaccg cttcatggat 120
gagttctttg agcaggtgga ggagattcga ggcttcattg acaagatcgc agagaacgtg 180
gaggaggtga agcggaagca cagtgccatc ctggcatccc ccaaccccga tgagaagacg 240
aaggaggagc tggaagaact catgtccgac ataaagaaga cagcaaacaa agttcgttcc 300
aagttaaaga gcatcgagca gtccatcgag caagaggaag gcctgaaccg ctcctccgct 360
gacctgagga tccggaagac acagcactcc acgctgtcca gaaagtttgt ggaggtcatg 420
tcggagtaca acgccacgca gtccgactac cgcgagcgct gcaaaggccg catccagagg 480
cagctggaga tcaccggcag gaccacgacc agtgaggagc tggaggacat gctggagagt 540
gggaaccccg ccatctttgc ctctgggatc atcatggact ccagcatctc gaagcaggct 600
ctgagcgaga ttgagacgcg gcacagtgag atcatcaagc tggagaacag catccgtgag 660
ctacacgaca tgttcatgga catggccatg ctcgtggaga gccagggaga gatgattgac 720
aggatcgagt acaatgtgga acacgcggta gactatgtgg agagggccgt gtctgacacc 780
aagaaggccg tcaagtacca gagcaaggcg cgccggaaga aaatcatgat catcatctgc 840
tgtgtgatcc tgggcatcgt catcgcctcc actgttgggg gcatcttcgc ctagaagcca 900
cccaaactgc cactccactc caggtgggcc actccaagga ggccctggct gctgccacct 960
ggctgggctg ccctcccaac ccccgcctct ggctcagagc accctccctc ccggccccca 1020
tgctcccttc tctgccatgg gccctccgtc cccgccccgt gtcgtgtgca tgatctctgt 1080
gagtgtgcgt ctgtacggga agaggcagag ggaggcagcc agcggggcgt gatgcagtgt 1140
gcacagcgag gagcagaccc aggcagggcc gccagggtga cacaggccac ccttccttgc 1200
cttcagtaac tcggtgggcc caggttctgc tcttccctgg ggaccctaac ctcgcctcca 1260
gctgacctgc cctgtcctct ccagctgtcc ccacaagcag agccctgagg ggtggggacc 1320
agctggccac atggtgctgc ttttcaggtt aggggagagg tggccctgag ggacagccca 1380
gctctgagtc tcagtcgctg atcactgcca gggaggctca ggctgccatg gctccaggct 1440
ccctcccctg cctaggggca aagtccatcg ggtcctgggc ctcagcttcc cttcccacat 1500
tcctccggcc ccaggagcaa ccccttgggc taggtctgac cccaggtgtc cctctggaag 1560
gggctggctg gtgccctatt tccagccacc ccagcagcta gggaggcaaa gcaggctgca 1620
gtcagtccct caagccagcg ttgcatgttt gggatggtgg ctcctgttgt cttgcgctct 1680
gggaagtcag atgtcatttc aggcctgcag tctcatcctg cccttgccat cctcccatcg 1740
atgtgccacg tgggtgtcac gtgtcccaga tgcagtattc ggcagccagc cggggagggc 1800
tacctcctcc tcctcaccac cttggggctt ctcatgggaa atgtgccccc gccccaggac 1860
cctctccctt gtggacaggc agggagatgc atgcgagtgc atgcagcagg ggatggggcc 1920
gtgtccgtgt gccccaccct ccctcggctt tactcctgcc cagtgactgt gaccactgtc 1980
cgtgttgcct tcttgaacag cgattccccc caaccccttc accaaaggtc ttggtacaac 2040
cagctgccca ttttgtgaaa tttttatgta gaataaacat ttgtatctgt 2090
<210> 31
<211> 1960
<212> DNA
<213> 人类
<400> 31
ccaggctgca cggtaggacc ggggcgaggg gagccaggcg gtcagggcgg aggccaagcc 60
cgggagatgc ggttgcagcc gccacggctg ttggggcgcc tggcgctccg tccgaggcgg 120
gtggctgtga ggccagggga gtaggcaggc tcccagagag attcttccaa gttggcgggt 180
ggcgggagag ggggccgcgc gccccggcgc agctgctttg tgcgcgcaga gagggactcg 240
tgtccctggt tctctccaac cctgggaccc gttgtgcggg cagtattggg caagccgcag 300
aacggagcga tttcctccga gaaagttgag gatggagcct ttttttccgc accgtccccg 360
cgatggcatg ggccccgaga atgctgcccc gaggctccca gtgtggggga gctcggggtc 420
gctgcgcctc tagcttgagc gcagaaatcc gcgaatcact ccgatcttcg cgaactctgg 480
catcttctag gaaaatcatt actgccaaaa ctgaggcgag cttttctggc gggcacggca 540
ccctgccccc agggcgctgg ccctgggcga tgcccccttt ccgatctcag gcttggtcaa 600
gggcgccagg ttccgaattc gcgcttgccg tgcacgccgg catcgagcct caccaacacc 660
gccgggcaac gtggctggag tagattcact gcgtgctgtc ctcacttgtt ctacaatgag 720
tgccaaatct gctatcagca aggaaatttt tgcacctctt gatgaaagga tgctgggagc 780
tgtccaagtc aagaggagga caaagaaaaa gattcctttc ttggcaactg gaggtcaagg 840
cgaatattta acttatatct gcctgtcagt gacaaacaag aaacccacac aggcgtccat 900
cacaaaggtc aaacagtttg aaggctccac atcatttgtt cggagatcac agtggatgct 960
cgagcagctt cgccaggtta atggtatcga tcctaatggg gattcggcag agtttgattt 1020
gttgtttgaa aatgcttttg accagtgggt agccagcaca gcgtcagaaa aatgcacctt 1080
cttccagatc ctccaccata cctgccagag gtacctcacg gacaggaagc cagagtttat 1140
taactgccaa tccaaaatta tgggaggaaa cagcatcctc cattcagctg ctgacagcgt 1200
gaccagcgca gtgcagaagg caagccaggc cttgaatgag cgtggagagc gattaggccg 1260
agcagaggag aagacagaag acctgaagaa cagcgcccag cagtttgcag aaactgcgca 1320
caagcttgcc atgaagcaca aatgttgaga aactgcctat cctggtgact cttcttaaga 1380
gaaactgaag agtttgttca gcagttttta caagaattcg ggacctccgc ttgcttcttt 1440
ttttccaata tttggacact tagagtggtt tttgtttttt cttttcagat gttaatgtga 1500
aagaaagggt gttgcatttt tacatttccc taatgatctt gctaataaat gctacaatag 1560
catcggcttc attttgggtt tttgcctcct cccactgtgt gtatgtgtgt atatgtatgt 1620
tttgaatatg ttttctttat taaaaaatat tttttgtagt ttgaatatga aatttggacc 1680
aaatgataaa ctgcgctgag tctaaactgg caacatgtat ttttttctct gatattaagc 1740
aggaaggcat tttaatgtgg tgacatcaga tgttattttt cctagatgaa aataaaagtc 1800
aagcagtgat tagtttcact cactgtccta gctacactta atttgaagat taaaattcta 1860
cattgtggaa aacaattgaa tttattggga aaaacagcag tcttagattt tgctccttgc 1920
atagtaatct tttgcatgaa ccatcaccag cgttcaaaaa 1960
<210> 32
<211> 970
<212> DNA
<213> 人类
<400> 32
gggcttcagg acaattcgtg atggcggggg ctggttccgc cgctgtatcg ggggcaggga 60
ccccggtggc ggggcccaca ggccgcgacc ttttcgccga agggctgctg gagttcctgc 120
gacccgctgt gcagcagctc gactctcacg tacacgccgt cagagagagc caggtagagc 180
tccgggaaca aattgacaac ctagccacag aactgtgccg cataaatgag gatcagaagg 240
tggccctgga tcttgacccc tatgttaaga agctacttaa tgcccggcga cgcgttgtct 300
tggttaacaa cattctacag aatgctcagg aacgactgag acggctaaac cacagtgttg 360
ccaaggaaac agcccgcagg agagcaatgc tggattcggg aatttacccc cctggctccc 420
caggcaaata acagatgagc ctatggactc agtagcacaa gtactgttcc ccagctgcct 480
tgtttcaaca gacatgcaaa gatcctagga gacagtcccc atagaccttc agacattaaa 540
aagggagccg tacagtttgt ttgaagcact tcgtcttacc catttatgta ggggccccag 600
gaaacctaca cacagccaga atgaggttcc caaaggactt acattaatta tggctcttgc 660
ttcctttcac aaatgagctg aggcctctac tttttttttt ttaagctgca tacttgaggc 720
ttaccttctt caggactagt taaccagagg ggcttccttt gtatgttaca tgcctggtta 780
catgggcctg gacagcatgt cctctacctg tgacttctca ttttcctgtt tacactgggg 840
atttggaggg ggcaggcaaa gtcaaagtga atgacctctg tccacccact tttttattgc 900
actggcttga atacagtagc agtgttgata gaatcatttt attcaataaa tacttaaaat 960
gaaaaaaaaa 970
<210> 33
<211> 3250
<212> DNA
<213> 人类
<400> 33
gagttcggag tagagatggc cgcgcttgca ccgctgcccc cgctccccgc acagttcaag 60
agcatacagc atcatctgag gacggctcag gagcatgaca agcgagaccc tgtggtggct 120
tattactgtc gtttatacgc aatgcagact ggaatgaaga tcgatagtaa aactcctgaa 180
tgtcgcaaat ttttatcaaa gttaatggat cagttagaag ctctaaagaa gcagttgggt 240
gataatgaag ctattactca agaaatagtg ggctgtgcac atttggagaa ttatgctttg 300
aaaatgtttt tgtatgcaga caatgaagat cgtgctggac gatttcacaa aaacatgatc 360
aagtccttct atactgcaag tcttttgata gatgtcataa cagtatttgg agaactcact 420
gatgaaaatg tgaaacacag gaagtatgcc agatggaagg caacatacat ccataattgt 480
ttaaagaatg gggagactcc tcaagcaggc cctgttggaa ttgaagaaga taatgatatt 540
gaagaaaatg aagatgctgg agcagcctct ctgcccactc agccaactca gccatcatca 600
tcttcaactt atgacccaag caacatgcca tcaggcaact atactggaat acagattcct 660
ccgggtgcgc acgctccagc taatacacca gcagaagtgc ctcacagcac aggtgtagca 720
agtaatacta tccaacctac tccacagact atacctgcca ttgatcccgc acttttcaat 780
acaatttccc agggggatgt tcgtctaacc ccagaagact ttgctagagc tcagaagtac 840
tgcaaatatg ctggcagtgc tttgcagtat gaagatgtaa gcactgctgt ccagaatcta 900
caaaaggctc tcaagttact gacgacaggc agagaatgaa gcctttgtat gacagaccca 960
tgtatttttg gcatgaggaa ctaacagtcc attactctat cttcagccta tcaggatcac 1020
agttttaagg aagacttggt tttgttgaat atgacaatga aatctgtgtg tatcagattt 1080
ttattgaagc attcatcagc agcctcaacc agttttcatt gtccatttac tagattcaat 1140
cgtctctgag tatatagggc tgatgttagc aagaccctaa aaatgtccat tgaaccctgc 1200
ttcaaaaaat gaaaacacac ctctataaaa tgtgtactgg gaataagctt tgtatttaca 1260
tacattaggg gaatttttta aaatctgtaa tgtttggaca aacagatgat attactttgc 1320
tataaaatta taaatgtaac ttttaataaa gatagccaga atattctaaa ttagaaatta 1380
cgtttttgtt tccctcaaga cataaaacaa atataaacat tctaaactgc tggatgaatc 1440
tgaaaagaca ttaagttcaa attttaattt attctcatat taaatataac tccattaaaa 1500
gtttaaaatt tcatgggaga aaatataata aggtaaagag gtagaatcac tttcagactt 1560
aagaataatg ttgatttccc aagtgcttta ccttatctgt taaagcgtaa gatgaattgg 1620
tatttgcttc ataggcagtt tgactgcatg tattagagaa tgaaaagaag atatttgtag 1680
taatgcctgg aaacttggtg ctttaaatta aggtactcct ctgctgctgt agaatggatt 1740
ccacacagtg gatagctatg ggtgattcag aatattatgt ttagattccc atttgttaag 1800
tttataagtt ttgtggggaa ttatgaactt actgtgtact acctgcattt gtgctgtgtg 1860
aaaaataaat acaaggattc gtttagctaa ttcaacttac tacaaagaca aatgtctgtt 1920
tttatttgcc tgctaggatt gtctttttta aaagtcattt ttatttatag gaatatgggt 1980
gtttctatag gaagaaacag gttttttgtt ttttgttttt taagataaat ttgacaaagt 2040
taactgaaat ttatctggtc cattttattc atgctactaa gatgggaatc tttaaacaca 2100
agggtcagca agctttggcc catggattgg ccacctgtta cgtaaataaa gtttctttga 2160
aacaagccta cactcattca tttatgtttt gtctgtggtt gctttccaca actgcagagt 2220
tgtatggctt gcaagtctaa aaacatttac tatttggccc tctaagaaaa agttaagaca 2280
cctagtctaa tggccttttg ggaaaaaaca aatcactaac tcataatcat ttatatccat 2340
tattttctgc ataaatgtaa tgctattgta cagggtttgg tagaataaat attcagactg 2400
actaaactgt tctaaatcct cacaaaaaag tccccaaaca acatgcctcc taaaaaacat 2460
tttcctatct tttacaagag gtatgaacat ttgtagggtt ccacatttgc atctagaaat 2520
ccaatgctct ttagaatgtt attacgaata gaaagatggc caggatgacc tttagtgtta 2580
catgatgttc agcaaatttt aattcaaacc ttgatatgcc tggacactga aaagtaaacg 2640
catcacctcc tattttatac cctaccttct ggttcccaat tgggagagca catagaggga 2700
aggagacaat atagaaacta cggagtccgc tggtagtggg ctgcatggtg tgacagagcc 2760
cttctctgta aaatggaaat gacaccacta gccatctcaa tagttacaag aattaaaaga 2820
gatacagtac ctgaagtgct tagcgcatgg tagcatttca taaatgttta gtgtcaatac 2880
taatgctcta ataatgtaaa ttgttaataa tttatttccc taatatcagg aaatcccagt 2940
tgtctatgtg gcccagtgct taaaaacgcc ttcttgcatg aggggattga actatacaat 3000
gtttgttaac tttgtatttg tattttttcc tataaaatct taaaataaaa ttaggagatg 3060
tgttctgatg taacagtagg attagcaatt ttcatttatt ccttccatat atatttactg 3120
aatggctact atatgcctgg tattgttctt tgaaagcaga aacagcagga aaaaaagtcc 3180
ctccctcata gagtttacat tctaaaaggg aggaaataga taataaaata tacattacat 3240
ttaaaaaaaa 3250
<210> 34
<211> 750
<212> DNA
<213> 人类
<400> 34
agatgcgagg tgggcggggg caggctgaaa gttggagcaa gcaggaagtg aactgagggc 60
caccctggga ggaagccgac taggcgaatt cacttactga ccggcctggg ctgctctgag 120
acatggagga agccagtgaa ggtggaggaa atgatcgtgt gcggaacctg caaagtgagg 180
tggagggagt taagaatatt atgacccaga atgtggagcg gatcctggcc cggggggaaa 240
acttggaaca tctccgcaac aagacagagg atctggaagc cacatctgag cacttcaaga 300
cgacatcgca gaaggtggct cgaaaattct ggtggaagaa cgtgaagatg attgtcctta 360
tctgcgtgat tgtttttatc atcatcctct tcattgtgct ctttgccact ggtgccttct 420
cttaagtaac agggaacctc tcccacctgc ccttctcttc agggacaacc ctccataaat 480
gtgtgccaag agggtctcct ttcctgtctt cctctacaga gaatgctgct cggtcctcct 540
acccctcttc ccgaggccct gctgccatgt tgtatgcccc agaaggtacc ttggtccccc 600
ggaaggagag aaaaaagaga gatggactgt ggctgcattt cttgggtcct tagagtgggc 660
tggagagacc tagagggccc agcatgtggc tgggaaactg ttggtggcca gtgggtaata 720
aagacctttc agtatcccta taaaaaaaaa 750
<210> 35
<211> 2126
<212> DNA
<213> 人类
<400> 35
gatcggctcg atgagcggag gcgctgctgc ggcgctgcgg ccgacgccgg gtccgcacca 60
actgtctccc cctcccagct tcttacctcg gcttcctact ccttcccccg cccgcccagc 120
accgccagcc cgggagagct gccgggagtt ccccgggagc ctcaggtggt gactatcctg 180
ttgagaagca aaagatactt tgcaagtaaa aaatatgcct cccaagttta agcgccacct 240
caatgatgat gatgtcacag gttctgtgaa aagtgaaagg agaaatcttt tggaagatga 300
ttcagatgaa gaagaggact tttttctaag gggaccatct ggaccaagat ttggacctag 360
aaatgataaa attaagcatg ttcagaatca agtggatgaa gttattgatg tcatgcaaga 420
aaatattaca aaggtaattg agagagggga gagactagat gaactacagg acaaatcaga 480
aagcttatcg gataatgcaa cagcttttag caacagatcc aaacaacttc gaaggcaaat 540
gtggtggcgt ggatgcaaaa taaaagccat catggctttg gttgctgcta tccttttgct 600
agtgattatc attcttatag tcatgaaata ccgtacttga tttgatgaca gagatcttca 660
ttaaacaaga tctgggacag taataaaaga ttgctgcata atttaaatga aacctatgtg 720
tatataactt tcaaaacttc tttttcaaga aactaagagg caagtatcac ttcaaattgg 780
aacgttgaga atgtccaatt atcttctccc tttctaacaa aatgttcttt taataattat 840
gtttaaggca aagagaacta gcctctattt ttccatattt caaggatcta atttgaaact 900
agatacttgc cagttcatta tttgtgtata taaacactga ttataatatt tcatattaat 960
attttaatgg cataaggact tgcattattg cattagggag cgggtcatgc tgggggtcag 1020
gaagcctgtg tagagtacca aattatatgc tgaaagagat gcataaccat tctgtcaata 1080
tttgcagaaa tatagttcct ttcatattac agttgttttg caagcaattt ccacatttat 1140
aggtgtaaca aaagctaaat gttgtaaatg ttgttgccct caggtataac taaaaacatt 1200
ccagtaaata tatttttgac tgtgtaagag aatgtgtagt aatttttttg gcattggatt 1260
atggaaatgg aaatttttaa acagtgtgaa aaaacatggt atggcatcat aaaactggag 1320
ataataaagt tattgaagag tgtcattgga gtatttgaaa atgaccaata tatagctgcc 1380
agtcatggtc cagtctgttt tctgttaaac tccaataaag agagaccagt cagtcctaat 1440
gtgagtaaat gaaatttaca ggtaacttac ttactcctta attttatttt agttaatagc 1500
ctctaacttc caactatctc atttaccaaa agtacaaaaa gtagcaaaac catctattaa 1560
tactttgaat tttatatctt tgcatttcct gttcatcctt gaggagatgt atgttgcaca 1620
atcaaatttt gcatcagcca acagtaatga gtagtagaaa gtcaggaacc tatgtgtata 1680
tatatatata tatatatata tatatatata tatatatata cacacaaaca cacacacaca 1740
cacacacaca cacgcacaca tatgataatc agtcagtcgg taaccaaatg ctagagagtg 1800
accattaacc taagcctgtt tttataatga aaaaatgtgt taactttaaa atatgccaac 1860
ctccttgtgt cttttaaaca agtcagagtg aaaatacatt gtcccctaag gtgtggggag 1920
aggaagcttt ataataaaat tagtgattct gcagaaactt gtgcactgga tatcttgaca 1980
atatgaatat aaaactccct aaattaaaaa tagggttaat agaaattatc agtatttaaa 2040
tagggaaaaa tgattttatg tttattttat ttaggtttta tttctttggt catcttaatg 2100
caaaatgaat aaagcataga atctgg 2126
<210> 36
<211> 2863
<212> DNA
<213> 人类
<400> 36
ggagttcgcg cgacgaccgc ggggtcggcg ggcggggcga ggccctggac ggcggcggca 60
gtggggctcc tccttctgtt tcccagaccg agagccgcgc cggcaccatg tcagcttacc 120
ctaaaagcta caatccgttc gacgacgacg gggaggacga aggcgcccgg ccggcccctt 180
ggagggacgc ccgagacctc cccgacgggc ccgacgcgcc cgcggacagg cagcagtact 240
tgcggcagga ggtcctccgc agggctgagg ccacggccgc cagcaccagc aggtccctgg 300
ccctcatgta cgagtccgag aaggttgggg tcgcctcttc cgaggagctc gcccgtcagc 360
gaggagtcct ggagcgcaca gagaagatgg tggacaagat ggaccaagat ttgaagatca 420
gccagaaaca catcaatagc attaagagcg tgtttggggg gctggtcaat tacttcaaat 480
ccaaaccagt agagacccca cctgaacaga atggcaccct cacctcccag cccaacaaca 540
gattgaaaga agctataagt acaagtaaag aacaggaagc aaagtaccag gccagccacc 600
caaaccttag aaagctggat gatacagacc ctgtccccag aggggctggt tctgccatga 660
gtactgatgc ttacccaaag aacccacacc ttcgagccta tcaccagaag atcgacagca 720
acctagatga gctgtccatg ggactgggtc gtctgaagga catagccctg gggatgcaga 780
cagaaattga ggagcaagat gacattcttg accggctgac aaccaaagtg gacaagttag 840
atgtcaacat aaaaagcaca gaaagaaaag ttcgacaact ctgaagacag acggatttcc 900
actctattgt gatgaaaaga tttgaaagat ctttttttga acttccaaga aatttcattt 960
actattttag tatgtaaatt aatgtgtgtt tgcaaatgtt ataatagagt aggtcttaag 1020
acatttttgc tgttataagg aagtgtttgt cccacatttt cctagggtta acacctcacc 1080
aagttcttcc agcaaaatgc ttattagagt ttttgtctga gcacagtagc ctggccctgc 1140
atatcttggg cgtttgatta ccatgctgga ataagaagag ttgcatttct cattttaatg 1200
agcatatgga aagatgggaa cagaatttca gtcttgcagc catgagcctc tatttctcat 1260
tcctaagcct taccatgagt cagagtgtta agggggcctg tgagccagtc gtttggtgga 1320
ggagggtcct tcccacacct ttgtttagga gtcatcattc acacacacac acacacacac 1380
acacacacac acacacacac tctgagcaca ttatctgtga ttctttcatc ctcccagaaa 1440
ggatcagtgt tagaatggga aatagagtgt gccatcttgc tcttttgttg gcagatgtcc 1500
ccgcttccct ccagcccccc atccttggca tgtatattag taggagggct tcacaccagc 1560
actgctcact gcgactcctg gaaatgtgtg gggaattggg tgagcccctc ttccccacgt 1620
gctcccatct gtaactctcc atctgtgatt tgcaacaggt cttccactgg ctcgaggctg 1680
cgaggctgac cgacaggggc gcccaataga gtttgtggga atggagtatt gcacagatgc 1740
agctgcacaa tggtcttcct ccacccctct gggaatcacc attaggcagg cctcagtagg 1800
gcaaaatgtt tatttggtac cgggggtctc ctgacctgtc tagcattccc acccactctt 1860
ctgcacttct tgcaaggtaa cttgaatcat cacttatttc tctgccacct ggttttagga 1920
ctggcactct ataaatgacg ctgactttgt atagaaggat tttgctaagg gggcaaaaag 1980
cccagatacc attttaactg gcccagctca ttttctcctt tcattttaca aaagaaatca 2040
tgcagaagca tcaattaaaa ctgatttatt tatgttggta catccaacaa aatagttgga 2100
gccacaaggc ccttgtcttt ttaaaaaaac aaaatatttt gaagatggtg aaagtgactg 2160
attttaataa tgagataggt cacttaaaat aacagtgcct ttgaccttaa aacatggcac 2220
tggcccatgt gacctttgcc atttcccagt acttcccttt acagtctgca gcctataaac 2280
agtggtgtct caaagcaaag gaaacctcca caagtgctgc aacagtgcat tagtttttat 2340
gtagcaattt gtttataaaa attcccatcc cataatgcat gaccttccta aaaataccca 2400
cagcctccat aggcaaggtg agctttctgt gctacccact ggttagattc cagccacctc 2460
agggattctg atccatgtca ttaacgacca tcccagggtg tgagggcctg attaaagctt 2520
atcgaactag acatttgttt attagatgag ctcggcatta ttattttctc aataactggt 2580
agaagggaaa ttttaaacat aacactcaac ccaaacaaaa ctacttcgtg aggctttcag 2640
caaaaaggct gcttaaaagc atgaacccgg gatgcagagc agcttttgtg cacggttcca 2700
cttactgtaa ttgtttctgg ttctttcctc taacaccttc catgtatgtc aactttttat 2760
caccgtcagg catagactcg tggagattag tcattatagc tcagacctaa gctaattatt 2820
taaaataaat acatgtaaag gccactgcca cattctcagc aga 2863
<210> 37
<211> 2159
<212> DNA
<213> 人类
<400> 37
tctttccgtc ccgggcagcc agcgccagtc ggagccagcg cgagcgccgc cgccatcact 60
gccgctgcca agtcctccac ccgctgcccc cgccatgtct gctaccgctg ccacggcccc 120
ccctgctgcc ccggctgggg agggtggtcc ccctgcaccc cctccaaacc tcaccagtaa 180
caggagactg cagcagaccc aggcccaggt ggatgaggtg gtggacatca tgagggtgaa 240
cgtggacaag gtcctggagc gagaccagaa gctgtcggag ctggacgacc gtgcagatgc 300
actccaggcg ggggcctccc agtttgaaac aagcgcagcc aagctcaagc gcaaatactg 360
gtggaaaaac ctcaagatga tgatcatctt gggagtgatt tgcgccatca tcctcatcat 420
catcatagtt tacttcagct cttaaatccc cgaggagtct gccctgccta gagaagggcc 480
tctcccccaa ccctcagccg ttcctccacc tctcagccat atctttcagc cccccctccc 540
ctggatccgt gtgtgtgtgt gtccgtgtgt gtgtccccct gtaaatagcc agctgttatt 600
tatacatata taatattata tatatttggt ctgtttgtag ttttattact agatgatttt 660
tccggttgtc cttaacaccc cttcctgagg ttcccttcac ccctctctct tgccttcctt 720
ccctttccct ttcttcctga ctagccccaa gtcccttcat ttgcatctgc tatgcaatag 780
tccctctcct ttccttcttc ttccctcaga tttagctgat ccttcctccc accctggcct 840
tcctttcctc tttcctcctc actctccccg tcatgctccc tctgccccgc cctcaaaaaa 900
aaaaaaaaaa aaaaaaaaaa aaaaaaccac cagcacctgt ccaggcttcc ttaggtacat 960
cttctttgta tccattggga ggctctgaga ctggccccac ttggtcctaa aaatcccaag 1020
gtctttggga gcgtccagca tgttaattag cgtatcatta catactgcta tccctttcca 1080
tttctttttg ttccatcact cttctctcaa cctgtgtttc tttttttact gaggagttag 1140
tccccattag ttcttgtatc acattttcat ttgcacgaca ttactcgcag gtggtgggga 1200
gcctgggctt ttggggaacc aggctgctct ggtccccagc attgcctcct cctagcccct 1260
ctagtccagt ttgcctccct taccctcatt ttccaaacct cttgtaccct cctctccctc 1320
ccccagtggt atgtaagtgt cttgaagttc agtatgttat gatggaccaa taattctgcc 1380
cttcgggttt ctccctacat tcctgctccc cagttttcat gtggggtact caactgacat 1440
tcccatgggg tttccctccc atctgcctga tccacctcct cctcccacca caagatcaat 1500
tgttggccac aattgatctc ttgtagaggg gtggctacca gtgtgtgtgt gggggtcatc 1560
actgccttgg ggaggagtgg ggcagggcag agaatccccc caattcctgc ctgaaatctc 1620
tggcctcacc cctgctgggg gttggactga aaaccctcct ccccaatttg gggggtgttg 1680
ccccatcact gcccagctcc tctgactgcc ccccctgaat ttagggtggg ggtactagtc 1740
actgccaatg tgtgtatggg acttgctgga aaacggggat gcttgcccct ctccaggact 1800
attgagccca gagagagctg tcctctcatt gggtgaactg attgaggaag ggtctattgt 1860
ctttttaaat ggcacaattt taagggtttg agggtacagt cccttaacct gccacgggag 1920
ggggccccca aactttcttc ccccccacac ttctggtttt ctgtgtggag ggggagcagg 1980
gatatctaag ctgtggtgtg aaagggtagg agagatgctg gaggtggggg tgctgtgttc 2040
tagacccccc atattatccc agtgtcccct gcccccctct tcccccaccc catgccccca 2100
attctgtggc gcatccagat tgtgaaaatg tacaataaat gtgtaatgag taaccaggt 2159
<210> 38
<211> 670
<212> DNA
<213> 人类
<400> 38
gctcttcctc cggggccgct ggcactgcgg ccgctccgca ggcagagaag ccgggagcgg 60
gcgaggcggc ggcggcagca gcgatggcag gaatagagtt ggagcggtgc cagcagcagg 120
cgaacgaggt gacggaaatt atgcgtaaca acttcggcaa ggtcctggag cgtggtgtga 180
agctggccga actgcagcag cgttcagacc aactcctgga tatgagctca accttcaaca 240
agactacaca gaacctggcc cagaagaagt gctgggagaa catccgttac cggatctgcg 300
tggggctggt ggtggttggt gtcctgctca tcatcctgat tgtgctgctg gtcgtctttc 360
tccctcagag cagtgacagc agtagtgccc cacggaccca ggatgcaggc attgcctcag 420
ggcctgggaa ctgacccagc tggtcctgaa ggagaagcca aatggctgca ctggccgatt 480
ctggtctcca gaggaccttg gtgtttgctc tcccttgacc caccccagtg agtgccaaag 540
ggcagcccca acatgtgcac ccctgcattt cctgtcatgc cacagactgg cccttgaggg 600
cagcctgctg tactggccat gctgggccag ccccacctgg agctcagtaa aaactgctgt 660
ttgataaaaa 670
<210> 39
<211> 2053
<212> DNA
<213> 人类
<400> 39
catctttgat gagggcagag ctcacgttgc attgaagacg aaacctcggg gaggtcaggc 60
gctgtctttc cttccctccc tgctcggcgg ctccaccaca gttgcaacct gcagaggccc 120
ggagaacaca accctcccga gaagcccagg tccagagcca aacccgtcac tgacccccca 180
gcccaggcgc ccagccactc cccaccgcta ccatggccga agacgcagac atgcgcaatg 240
agctggagga gatgcagcga agggctgacc agttggctga tgagtcgctg gaaagcaccc 300
gtcgtatgct gcaactggtt gaagagagta aagatgctgg tatcaggact ttggttatgt 360
tggatgaaca aggagaacaa ctcgatcgtg tcgaagaagg catgaaccat atcaaccaag 420
acatgaagga ggctgagaaa aatttaaaag atttagggaa atgctgtggc cttttcatat 480
gtccttgtaa caagcttaaa tcaagtgatg cttacaaaaa agcctggggc aataatcagg 540
acggagtggt ggccagccag cctgctcgtg tagtggacga acgggagcag atggccatca 600
gtggcggctt catccgcagg gtaacaaatg atgcccgaga aaatgaaatg gatgaaaacc 660
tagagcaggt gagcggcatc atcgggaacc tccgtcacat ggccctggat atgggcaatg 720
agatcgatac acagaatcgc cagatcgaca ggatcatgga gaaggctgat tccaacaaaa 780
ccagaattga tgaggccaac caacgtgcaa caaagatgct gggaagtggt taagtgtgcc 840
cacccgtgtt ctcctccaaa tgctgtcggg caagatagct ccttcatgct tttctcatgg 900
tattatctag taggtctgca cacataacac acatcagtcc acccccattg tgaatgttgt 960
cctgtgtcat ctgtcagctt cccaacaata ctttgtgtct tttgttctct cttggtctct 1020
ttctttccaa aggttgtaca tagtggtcat ttggtggctc taactccttg atgtcttgag 1080
tttcattttt cattttctct cctcggtggc atttgctgaa taacaacaat ttaggaatgc 1140
tcaatgtgct gttgattctt tcaatccaca gtattgttct tgtaaaactg tgacattcca 1200
cagagttact gccacggtcc tttgagtgtc aggctctgaa tctctcaaaa tgtgccgtct 1260
ttggttcctc atggctgtta tctgtcttta tgatttcatg attagacaat gtggaattac 1320
ataacaggca ttgcactaaa agtgatgtga tttatgcatt tatgcatgag aactaaatag 1380
atttttagat tcctacttaa acaaaaactt tccatgacag tagcatactg atgagacaac 1440
acacacacac acaaaacaac agcaacaaca acagaacaac aacaaagcat gctcagtatt 1500
gagacactgt caagattaag ttataccagc aaaagtgcag tagtgtcact tttttcctgt 1560
caatatatag agacttctaa atcataatca tcctttttta aaaaaaagaa ttttaaaaaa 1620
gatggatttg acacactcac catttaatca tttccagcaa aatatatgtt tggctgaaat 1680
tatgtcaaat ggatgtaata tagggtttgt ttgctgcttt tgatggctac gttttggaga 1740
gagcaatctt gctgtgaaac agtgtggatg taaattttat aaggctgact cttactaacc 1800
accatttccc ctgtggtttg ttatcagtac aattctttgt tgcttaatct agagctatgc 1860
acaccaaatt gctgagatgt ttagtagctg ataaagaaac cttttaaaaa aataatataa 1920
atgaatgaaa tataaactgt gagataaata tcattatagc atgtaatatt aaattcctcc 1980
tgtctcctct gtcagtttgt gaagtgattg acattttgta gctagtttaa aattattaaa 2040
aattatagac tcc 2053
<210> 40
<211> 2053
<212> DNA
<213> 人类
<400> 40
catctttgat gagggcagag ctcacgttgc attgaagacg aaacctcggg gaggtcaggc 60
gctgtctttc cttccctccc tgctcggcgg ctccaccaca gttgcaacct gcagaggccc 120
ggagaacaca accctcccga gaagcccagg tccagagcca aacccgtcac tgacccccca 180
gcccaggcgc ccagccactc cccaccgcta ccatggccga agacgcagac atgcgcaatg 240
agctggagga gatgcagcga agggctgacc agttggctga tgagtcgctg gaaagcaccc 300
gtcgtatgct gcaactggtt gaagagagta aagatgctgg tatcaggact ttggttatgt 360
tggatgaaca aggagaacaa ctggaacgca ttgaggaagg gatggaccaa atcaataagg 420
acatgaaaga agcagaaaag aatttgacgg acctaggaaa attctgcggg ctttgtgtgt 480
gtccctgtaa caagcttaaa tcaagtgatg cttacaaaaa agcctggggc aataatcagg 540
acggagtggt ggccagccag cctgctcgtg tagtggacga acgggagcag atggccatca 600
gtggcggctt catccgcagg gtaacaaatg atgcccgaga aaatgaaatg gatgaaaacc 660
tagagcaggt gagcggcatc atcgggaacc tccgtcacat ggccctggat atgggcaatg 720
agatcgatac acagaatcgc cagatcgaca ggatcatgga gaaggctgat tccaacaaaa 780
ccagaattga tgaggccaac caacgtgcaa caaagatgct gggaagtggt taagtgtgcc 840
cacccgtgtt ctcctccaaa tgctgtcggg caagatagct ccttcatgct tttctcatgg 900
tattatctag taggtctgca cacataacac acatcagtcc acccccattg tgaatgttgt 960
cctgtgtcat ctgtcagctt cccaacaata ctttgtgtct tttgttctct cttggtctct 1020
ttctttccaa aggttgtaca tagtggtcat ttggtggctc taactccttg atgtcttgag 1080
tttcattttt cattttctct cctcggtggc atttgctgaa taacaacaat ttaggaatgc 1140
tcaatgtgct gttgattctt tcaatccaca gtattgttct tgtaaaactg tgacattcca 1200
cagagttact gccacggtcc tttgagtgtc aggctctgaa tctctcaaaa tgtgccgtct 1260
ttggttcctc atggctgtta tctgtcttta tgatttcatg attagacaat gtggaattac 1320
ataacaggca ttgcactaaa agtgatgtga tttatgcatt tatgcatgag aactaaatag 1380
atttttagat tcctacttaa acaaaaactt tccatgacag tagcatactg atgagacaac 1440
acacacacac acaaaacaac agcaacaaca acagaacaac aacaaagcat gctcagtatt 1500
gagacactgt caagattaag ttataccagc aaaagtgcag tagtgtcact tttttcctgt 1560
caatatatag agacttctaa atcataatca tcctttttta aaaaaaagaa ttttaaaaaa 1620
gatggatttg acacactcac catttaatca tttccagcaa aatatatgtt tggctgaaat 1680
tatgtcaaat ggatgtaata tagggtttgt ttgctgcttt tgatggctac gttttggaga 1740
gagcaatctt gctgtgaaac agtgtggatg taaattttat aaggctgact cttactaacc 1800
accatttccc ctgtggtttg ttatcagtac aattctttgt tgcttaatct agagctatgc 1860
acaccaaatt gctgagatgt ttagtagctg ataaagaaac cttttaaaaa aataatataa 1920
atgaatgaaa tataaactgt gagataaata tcattatagc atgtaatatt aaattcctcc 1980
tgtctcctct gtcagtttgt gaagtgattg acattttgta gctagtttaa aattattaaa 2040
aattatagac tcc 2053
<210> 41
<211> 2588
<212> DNA
<213> 人类
<400> 41
gaattcgccg gtccagcctc ctctgggagc gggcagttgg cgaccctgca ctgacccgcg 60
tccctccgtc ccgagcccgc gcgccctcag agggtgcccg gacagactga agccatggcg 120
attctttttg ctgttgttgc cagggggacc actatccttg ccaaacatgc ttggtgtgga 180
ggaaacttcc tggaggtgac agagcagatt ctggctaaga taccttctga aaataacaaa 240
ctaacgtact cacatggcaa ttatttgttt cattacatct gccaagacag gattgtatat 300
ctttgtatca ctgatgatga ttttgaacgt tcccgagcct ttaattttct gaatgagata 360
aagaagaggt tccagactac ttacggttca agagcacaga cagcacttcc atatgccatg 420
aatagcgagt tctcaagtgt cttagctgca cagctgaagc atcactctga gaataagggc 480
ctagacaaag tgatggagac tcaagcccaa gtggatgaac tgaaaggaat catggtcaga 540
aacatagatc tggtagctca gcgaggagaa agattggaat tattgattga caaaacagaa 600
aatcttgtgg attcttctgt caccttcaaa actaccagca gaaatcttgc tcgagccatg 660
tgtatgaaga acctcaagct cactattatc atcatcatcg tatcaattgt gttcatctat 720
atcattgttt cacctctctg tggtggattt acatggccaa gctgtgtgaa gaaataggaa 780
agaagaagtt accattaacc aaggatatga gagaacaagg agttaaaagc aatccatgtg 840
actcaagcct ttcacatact gacagatggt atctgccagt ctcttcaacc ctcttctcac 900
tttttaaaat cttgttccat gcctccaggt ttatctttgt cttatctacc agtttattcc 960
tgtgaacttc agattgaacc attcattgca gcagtagcct taaaaaggct tttgtttatt 1020
tctttggttt gttaactagt gtcatctatt tagagaaaca tttttgtttt taattgctca 1080
aagctgtcgc cgctagtctt atgagctatc tactaaaact atggagaaac tttgtatgtg 1140
cacacaaaag tattcaagag acagtattgc taacatctca tcttaatgtc ttttgttatt 1200
gagaagtttt aggtgcttca aaacaatata aatggataat agttgttatt tggggaattg 1260
taatgatgtt ggtgctgctt ccttctaaga gctcagacaa gtaaagtatg aaacattctt 1320
atttcagtta gatggggaac attttgctag cccattagaa gcacacagaa ttatccttgt 1380
cctcctaata ttgactttca ggaataaagt tcagtgtgct gatcattcac aatacagtgg 1440
atagcttgat atcttctgtt ttcccattgc agttgatttg agaagatgaa ggtttaaata 1500
ttgttgaaag ttgcagtttt ttaaatgtgt tcctttttct tctgtgaata tttagggcaa 1560
tcgtgtcgct aatagaatat gtagtagagg gggtggggag gtaaattcct ctgacttgcc 1620
aaagaaaaag aagggaacca cagtggatat gctagcattt tagctgtgca aagggaggta 1680
gtgtgggaaa agtgtttcca ttctgggaaa agcccaaacc gaatacggtc agcagtcaac 1740
tccagggttt gggcttgatt cctgttgaat aatagttttg agcattcttt gtggttaaat 1800
aaattcttaa atctgcctag ttttgatgaa ttcttttgtg aaacttgaaa gagaatagac 1860
agtatgacat atagaattaa tacaaaacag tttaacaacc atttaactgc agtgtaagaa 1920
aattggactg taatcatatc gctactggca tctgttatct agtatgcatt tctggtgtgt 1980
atctgaaagg aagacatttt ctaccctaga tccaattgca tttatttatc aataagtgcc 2040
attaaattga aattatatta cattttacac tttctcaatg aatgaacaaa ttagtctgta 2100
gaatctagcc acctgtttag cctagtcatg tgccttgaac atatatgtgt cccataatct 2160
ggctcatggt acctgttctt ctatccaaac ctttcaattc atgctacctg attcatttat 2220
ttgacataga tcttaggccc acttgaactc ttttcttgtt tatctagcat agcacaaacg 2280
tttttccagt cttctttatc aacactaatg cctcttaatt gcatcagtat ttcctattgg 2340
aaaatacatc tgttccagaa aaacatttgg cattcctgaa taatttccaa atgtttttaa 2400
tccaaagaaa aaggtttaaa gcttatttcc ctttcttata cacacctgaa taaaattgat 2460
gtgcatgttt tagggatcaa ttacctaact gttccttggt ctatttatgt ataagaatgc 2520
tttttaaagc acatgtctca ttttaaatga cgcacaaact gaagatgtta ataaaattta 2580
aggaattc 2588
<210> 42
<211> 1753
<212> DNA
<213> 人类
<400> 42
ggccgcggcg ccccccggcg cccccagacc ccggcctccg gcacagaggc gggagacccg 60
gagcagcagc agaggcagga ggactaggag gaggaggagg agccgtcgca ggatgaagga 120
tcggactcaa gagctgcgga gtgcgaaaga cagtgatgat gaagaggagg tggtccacgt 180
ggatcgggac cacttcatgg atgagttctt tgaacaggtg gaagagatcc ggggctgcat 240
tgagaaactg tcggaggatg tggagcaggt gaaaaaacag catagcgcca tcctggccgc 300
acccaaccca gatgagaaga ccaaacagga gctggaggat ctcactgcag acatcaagaa 360
gacggccaac aaggttcggt ccaaattgaa agcgatcgag caaagcattg aacaggagga 420
ggggctgaac cgttcctccg cggacctgcg catccgcaag acccagcact ccacactgtc 480
ccggaagttc gtggaggtaa tgaccgaata taacgcgacc cagtccaagt accgggaccg 540
ctgcaaggac cggatccagc ggcaactgga gatcactgga aggaccacca ccaacgaaga 600
actggaagac atgctggaga gcgggaagct ggccatcttc acagatgaca tcaaaatgga 660
ctcacagatg acgaagcagg cgctgaatga gattgagacg aggcacaatg agatcatcaa 720
gctggagacc agcatccgcg agctgcacga tatgtttgtg gacatggcca tgctcgtaga 780
gagccaggga gagatgattg accgcatcga gtacaacgtg gaacattctg tggactacgt 840
ggagcgagct gtgtctgaca ccaagaaagc agtgaaatat cagagcaagg cccggaggaa 900
gaaaatcatg atcatcattt gctgtgtggt gctgggggtg gtcttggcgt catccattgg 960
ggggacgctg ggcttgtagg ccccccccac ccttctctct cccagaccct tcccccacca 1020
catcgggagc aataccccca ccaccccttt cactccatcc cctgctccag gctcactccc 1080
aaaacagacc caggcagccc cacccccacg gcagaccctg gtgtccctgg acctcaccgg 1140
gccatggacc ccccccccgt ccccgcacgt agatcgcagc aggcgtgatt acacatgcac 1200
accaacatgc atgccgccgg cacatgctcg agacgtgtgg acaccccagc gtgcgtgtgc 1260
gtgtgatgtg tgtgatgcac cagagcaccc cctccacccc caccttgggt gtgtgtgcgt 1320
ggtctgagct tcccccttca ccggggctgt tgtgtagact gcagccaagt gtaacacagc 1380
agtccatcac gccctctctg tcctctgtga acagtgtgtg tgcgtgcgtg agaccacaga 1440
tctgtggaca caccatttgt gtacgtggaa ttttgtgttt cagtgtttga acctaatgca 1500
acagcaacaa agccactgat acctgagccc tttgtgtctg ctacaaacca ggcaggtggt 1560
gtgtgtggac tcacactcac attctcagag gatccaggga ggcccaggta cacacaggcc 1620
atggcagaca ccccatgtct ttgttacccc aggggctgtg gcatgtccca ggagggtgtg 1680
catgtgtgtg tgtgtgtgtg tgtgtgtgtc caggatgtgc ctgaagtatt gataggtctt 1740
ctcagataga gcc 1753
<210> 43
<211> 6910
<212> DNA
<213> 人类
<400> 43
ctcgtgatgc cccgccccgt cgctcctgcg cctgcgccgt gcccaccgac cggcctcgag 60
cgccccggcg ggaggttttt ctatatgagt ggagaagaca gctgttacca gggaggtcat 120
acaacatttt tttaggatgt ctgaagatga agaaaaagtg aaattacgcc gtcttgaacc 180
agctatccag aaattcatta agatagtaat cccaacagac ctggaaaggt taagaaagca 240
ccagataaat attgagaagt atcaaaggtg cagaatctgg gacaagttgc atgaagagca 300
tatcaatgca ggacgtacag ttcagcaact ccgatccaat atccgagaaa ttgagaaact 360
ttgtttgaaa gtccgaaagg atgacctagt acttctgaag agaatgatag atcctgttaa 420
agaagaagca tcagcagcaa cagcagaatt tctccaactc catttggaat ctgtagaaga 480
acttaagaag caatttaatg atgaagaaac tttgctacag cctcctttga ccagatccat 540
gactgttggt ggagcatttc atactactga agctgaagct agttctcaga gtttgactca 600
gatatatgcc ttacctgaaa ttcctcaaga tcaaaatgct gcagaatcgt gggaaacctt 660
agaagcggac ttaattgaac ttagccaact ggtcactgac ttctctctcc tagtgaattc 720
tcagcaggag aagattgaca gcattgcaga ccatgtcaac agtgctgctg tgaatgttga 780
agagggaacc aaaaacttag ggaaggctgc aaaatacaag ctggcagctc tgcctgtggc 840
aggtgcactc atcgggggaa tggtaggggg tcctattggc ctccttgcag gcttcaaagt 900
ggcaggaatt gcagctgcac ttggtggtgg ggtgttgggc ttcacaggtg gaaaattgat 960
acaaagaaag aaacagaaaa tgatggagaa gctcacttcc agctgtccag atcttcccag 1020
ccaaactgac aagaaatgca gttaaaaacc aaatttcagt attattggtg ccaacatgtc 1080
tatcctgagg acctttgctg ctgttggaca ctccgtcacc ttttggaaca caagtatatc 1140
aagatagtgg ctactgatgt tcaagtggga ttgaagtgtg ataaatggat atattttgtt 1200
gtttgctggg gtgttcatgg agatgttaag agattgaggc cctgggctga gggtatataa 1260
tgtatgtcag gtaaagtttg aagactgcca aggagcagat tttctccctg gaaatgtgaa 1320
aactgaacct ataactctga taaggacttg agatgtgtag aaacgttggg ttatggaaga 1380
ctagtttctt ccataaccct gaattggaga ccttaatgct aagtgtagat tattgaggtt 1440
tgttagtgag gaaaagaata agagttcaga agcctttgtt atcagatagc gaaatcaggg 1500
cctagtgagg agcacaggtc gactacataa tggagtccat tggcgaaccc tattgcaatt 1560
tggtccaact atatcttctg gtgaaggaaa ttaatgatgt aagaaaatgc aagaggctca 1620
acttctcttc caaaaatctt ctggcttctg aactcttcct ctgcctctct ttaaataaat 1680
aacacagaat ttcaagtggt aggagactta ttaagccagt caccaagctt ggtctgtcag 1740
cctgtcttct aacacctcaa agatcttgtg ccctgtgctg tccctccctt gtaattatga 1800
aaagttcttt ggtttctggg gtgaattcta cccatgtata atgaggaatt ctctcataac 1860
cttttttgtc ttgtctgtca tctctgttca tcccttccta taacctctag gtaaaaagaa 1920
aagaaaaaaa gaaatttcga gatattttca acattgttag agtttgggct aaaatgagca 1980
aggagaaaaa aaccaccaag aacatttcct ggggcatgtt ccagttttga ggggtgatat 2040
atctgccaga tagggggtat ctgacccagt cttcttttca gctggtctct ggggggagct 2100
gagaactcgc ttgctacctc acatcctttt ccccagactt tttatctcct atgcatccct 2160
ttgctttcta tagctggtgt ttcttcccca aaatggcgtt cccatgctta cctttctcac 2220
attctagaca atgatggaca aagacgcatg caagactcag acccggggaa tggtgtggtg 2280
ctaatctcaa cacctgacat tcacagcaag catggcccag cccaactgca tgtctatctc 2340
aaaccgcaga aaggctttaa tactggaaaa aaagaattca agactacagg cagctcccct 2400
ctgtacccca actcatttaa aataggagga atcacttttt gccttactta acgctttttt 2460
ctgagcacag ggatgggcac ctgcacccca gaaggtgtga gctgtctctc tgccaggagc 2520
taaggttcat taggggattg gatggtttat cacttctttc tttctgagtt tacttttagt 2580
aacttttatt gatggctacc tttcatgtcc ctgtctaaag agactttctc tttcatacgt 2640
cttaaatctc atcaatgaaa tccagtgaaa cagcaccatt tcttagtatc attaaataac 2700
tagaaagtat caagtattgc tctctgctgc tttatatcat taacatatta ataataccaa 2760
gaaggaaata ctttgaataa gtgtcagatt ctgatccagt attggacacc tgtgatattg 2820
gacacctgtg aggctgggat aattactttt gaattacacc tcttctctag tttctggacc 2880
ttgctctgtc actttaacac agggtgatca aacctgaatg aggatcagaa ctcacccagg 2940
cacatactaa agcaagattc ctaaacctca gttccagggg taattctgac atcacccgtc 3000
cagcatagtc agctgaaatt ataaatctaa gaaacagtta catcaagatt ctgctgtgtc 3060
atttaattct gaaactccca gtattctacc cttcttcatc actgcatatt accccactct 3120
tccatcccaa attggctatc ctttcagccc accaacttag cggcagcact agggattcat 3180
tataaggtaa atctggttta cataaagacc tgaaggaggc ctgtatttga agctcacact 3240
tggtattggt atctctcatt tttactgagc cagtgtggaa taccactgta tgtactcata 3300
taagcccttg acttttactg ctcatcagga ttggaatatt actctagcag tcttcacaca 3360
taggcaagtt acagtccttt taaaaagtat ctcatttccc tataatggaa cctaatagcc 3420
aactttttca tagaaattgc tagaagagtt tgatcaacta taaatgataa agtgtttata 3480
agcatagtca gtgtgacaca gaaaccaatc ttaaaattga atttaatgtt ttatcatatc 3540
agattaaata ttttctccat gtcttatttt tactgcaaca agttagaaag tgggaacact 3600
ttgattaatg tcttaaaatt tgtgggccct catttggata aaggcagcaa tcctaaggac 3660
tttttttttt tttttaacat aatctgagaa tttctctgta gagcagagac tttcaaacct 3720
tttggctgta acccacagta aaaaacgcat ttatatcaaa ccttagaata tgtttaatga 3780
acaatactta ccattctgat gctttttatt gtttcagttt ttaaaatatg ccagttgcaa 3840
cccactaaat tgatatctac caatgggttg caacccttag cttgaaaaaa acaccctcac 3900
agaggaactg gtatttcttg aataccttct gtttgccagg cacttcacca ggcattttac 3960
aagtaaggaa actgggcttc agagaaaata atttgcagag gtttactcaa ctacaaaggg 4020
gtgaagccag gaatgttaac taggtctgtt gagctacaaa aacttttatg tctctcagac 4080
tatacagcct ctatacaaaa ttgagatggg ggttgggggc aggggctcat gcctgcaatc 4140
ccagcactta gggaggcaga ggccagagga tcacttgagc ccaggagttt gagaccagcc 4200
tgggcaacat agtgagactc ttgtctgtat gaaaaaaatt aagaattagc tgggtgtggc 4260
atagcacaca cctgtggtcc cagctacatg ggaagctgaa gtgggaggat cacttgaact 4320
caggagcagc cttggtgaca gaacaagacc ctctctcaaa aaaatattta aaaaaaggtg 4380
ggtcatccat tctcctttac caaacaggct ttgaaatgac acattccatt catttgcatc 4440
tttttaaaaa acttctgatt ccttactgag tgtccagcag cctcaaagtt tttaatggta 4500
gctgatgcag acataaacag tgctcaattt ggcccttaaa ctataaaatc aagaaagagt 4560
atttcaatcc catccacctg cctgcaagat ttcttaatgt tcactagtta taaccattgt 4620
ttaaacagtg ctttttgtgt aatttaaaaa taaactttaa tgctttttaa aacaaattta 4680
tcataattca tagatcaaat gattatcctt taaaatgata cccttgggaa atcatgtact 4740
tactgtagtg atgctagtat taatattact tagaccaatt ttgaaactgt tctttcagaa 4800
ttgcctccaa agacattttg cagatcatcc cagaaaaggg ggtatgatgg tgctgtgtag 4860
aactgaccag agttcctgga ggattttgag gttatactga aactgagtgc tgtacaggga 4920
gaattgcatg agtccagaaa cttccttctg tgggctgcct gccttcctgc cctcccttaa 4980
gtgctctaag atttttgtac aggagtaaga atcaaatact ggtaacatca atcacaagaa 5040
gttgaggaaa cctgtaatat agctagataa tatacaacgt ttgtcttcca tcagagtgca 5100
gaaaccaaac catgctttgt gttaacctta aatatgaaag gtgtttctca gggtcccctt 5160
tgtccttcgt tgctgccata tgaaatctta caaggaagga tgaggaaaag cctgggggga 5220
ggttctcctc ggaaatgagg tggttttttt tgttattaag tagaacgtgg ctgtggttca 5280
caggtactta acgaatgtta gatgatgttc ttaagtaatc agaggcctaa taaaaggcag 5340
gggagtttct cttctagcct aaattaatat taaaagttca ggggtatttt ttgtttttaa 5400
attaatactt tattgttttt aacaggtggt tctcataatt tacattcatt aatttgatgc 5460
ccttttacaa agaaacttct taggtattat aaaccatcaa tgtaaaggat ccacatggta 5520
tgtatccaca ttgctactct caaatagaaa tgggagataa gaaatatatc tgtgcaatat 5580
taaattgaaa aaaaaaaacc cataaaaagt gtcaaaggca aataatttgc tctagatcac 5640
aaaactagtt agcacaaggc taggattata accagggtct aggaaaaaat cctgaaggtg 5700
atttaactga gtgttaggcc ctgtcaagcc acctgctaag gctcatggtc tttcagacta 5760
gcttcaacat tccaaatcag gcaatagcta caacggaaag ataattggac ggggaatcct 5820
gagatcagag tcctagtttg gctttgtctc ttgtagcagg attttttaaa tcaggggcag 5880
ctctcttctc ccatcccagc catgaatctt tcaaccttag tggtcaccaa cttgactcca 5940
ttccttatat caagacttgt cctgtcaatt ctcccttaaa tgttagttgc atccatttct 6000
aaatatatcc atggccatca ccctagtaaa aagactatta cctcacaccc cgcacttgat 6060
cttcccccaa ctttaagtga ctcagttcct tatatcactg ccacaagaat taacaaccat 6120
gtccatcttt catttttctg ctgaaagatt ttcagtggtt cccactgaat accaaataaa 6180
gttcgaatcc cttagattgg cattcacagc cttctacgtt ctggccccag ctttatctct 6240
tgaaactcac tactcaccat ctgacaatgc cactaaaaat ccacaagagt gattttaagg 6300
tttttctatg gtgaaggttc aaactggtaa taaaccatgt ttacattttt ctggtctaaa 6360
ataatttcta tattacttta taatagtcag ctgggggtta tttaagctct tggacgagcc 6420
taaaacttgt atcctgaaga aaatattttt ttccaccaga agaaattgct ttcaatttct 6480
taaccttcaa aacaatgtca gtgttgtcac ctgtgcattt gatagccaca gcacaagtat 6540
tcttcaggag cataaatcct ccagccttga atggaccatt gtccagctcc tgtgaaaaac 6600
ttaatatttg agaaagacat tcaatggtac atgttttctg tacacttcat gagtagttga 6660
gattttcttg tattaaggtt aatcactaaa aaggtgttta cttgggtttc gttaactaaa 6720
ccccctaaag atgttttcca ttttattgtt aaacacttgg tgttagcaag ggtcagcacg 6780
agaaaaggcc caatggcaag aatttctgca aactctgtaa agcttactga attcatttgt 6840
catttattac attgctgagt ggtgcttgaa taaggaaaca tgcaataaat ttacttattt 6900
aaccaacaaa 6910
<210> 44
<211> 860
<212> DNA
<213> 人类
<400> 44
gcacttccgc cctctcttaa catggagccg gcggaagggg tggtgtaggg ccgggcgata 60
atggcggcgt cgaggctgga gctaaacctg gtgcggctgc tatcccgctg cgaggcgatg 120
gcagcggaga aacgggaccc ggacgagtgg cgcctggaga agtacgtggg agccctagag 180
gacatgttgc aggccctgaa ggtccacgcg agcaaaccgg cctctgaggt gatcaatgaa 240
tattcctgga aggtggattt tctgaagggg atgctgcaag ccgagaagct gacctcctcc 300
tcagagaaag cactggccaa ccagttcctg gcccctggcc gtgtgccaac cacagccaga 360
gagcgagtgc ccgccacaaa gacggtgcat ctgcagtcac gggcgcggta caccagcgag 420
atgcggagtg agctactagg cacggactct gcagagcctg agatggacgt aaggaagaga 480
actggagtgg cagggtccca gccagtgagt gagaagcagt cggcagctga gctagacctc 540
gtcctgcagc gacatcagaa cctccaggaa aagctggcgg aagagatgct aggactggcc 600
cggagcctca agaccaatac cctggccgcc cagagtgtca tcaagaagga caaccagacc 660
ctgtcacact cactgaaaat ggcggaccag aacctggaga aactgaagac ggagtcagag 720
cgtctggagc agcacacgca gaagtcagtc aactggctgc tctgggccat gctcattatc 780
gtctgcttca tcttcattag catgatcctc ttcattcgaa tcatgcctaa actcaaataa 840
agacccccgc ccacctaaaa 860
<210> 45
<211> 3080
<212> DNA
<213> 人类
<400> 45
gcacgcagcc ttagctcctt ccccgccctt gctcttccca gtttctccgt cagcctgcgg 60
gtcccggctg gcggctgctt ccggtaggag agcggtgtag agcgagcagg tctcagctcc 120
tcgtcatgtc atacggtccc ttagacatgt accggaaccc ggggccctcg gggccccagc 180
tccgggactt cagcagcatc atccagacgt gcagcggcaa catccagcgg atcagccaag 240
ccactgctca gataaagaat ttgatgagcc agctaggaac taagcaggac tcaagcaagc 300
tacaggaaaa tctgcaacag ttacaacact ccacaaatca gctcgccaag gaaacaaatg 360
aattgctgaa agaattaggg tccttgcccc ttcccttatc tacttcagaa cagcgccagc 420
agagacttca gaaggaacgc ctcatgaatg acttctctgc agccttaaac aatttccagg 480
ctgtgcagag aagggtatct gaaaaggaaa aggagagtat tgccagagca agagctggat 540
ctcgtctttc tgcagaagag aggcaaagag aggagcagct ggtctcattt gacagccatg 600
aggagtggaa ccagatgcag agccaggagg atgaggtggc catcactgag caggatttgg 660
aacttattaa agaaagagaa acggcaattc ggcagctgga ggctgacatt ttggatgtca 720
atcagatatt taaagatttg gccatgatga tccatgacca gggtgatctg attgatagca 780
tagaagccaa tgtggaaagc tcagaggtgc acgtcgaaag agccactgaa cagttacagc 840
gagctgctta ctatcagaaa aaatctcgca agaagatgtg tatcctggtg cttgtcctgt 900
cagtgattat tctaatcttg ggacttatta tctggctagt ttataaaacg aagtgattgc 960
ctccgatcgt tctcccgctg agctgttttc aagggcaagt gcttgttgaa gtcttgccag 1020
aacaaactga tcacaagaag acagcatata tcagaacgtc ctgtaatcat ttagttagaa 1080
actaactact aactagtctt tggaattcgt gacctatgga gacagtaatt atcaatttat 1140
tgattctatt gatttctcaa attaggaatt aacttatgtg gattttgctt cctcttgtat 1200
tctgattgcc cttcatccca agtgtttact gaaaattcca ttctagatat tcttgttttg 1260
acaaatgaca ctacagtctc gtaatattgt cttttatgta tatacaaaat ttaccttttt 1320
actagcatct gagatagagt tactttctgg tacccagtat attggagtct gtcagaaact 1380
ctataatagg ccaccagttt ttattattta acatttttat ttgaatttct aagaagccta 1440
ttctctatct attttgaaag attttggcac tatatttaat tggaaggtaa aatattgtac 1500
atgtgatcca gagtaaatga gaagtctcta tctgagctgg tcagttactg gagtacatgt 1560
tactaatctg ggtttaaagt ttacttcatt atctgctagt gtcatccaca gcagttcatc 1620
ctcatccaca ctaagccatc ctgttagctt ttaaaggaag ttaatttaat taacattaat 1680
atactctatg ggctccctct cccacctgtc tgcatagaaa ggcagaatta gacatagcat 1740
gctttggaaa agcaaatagg aattgttggg aatgatttaa tcttgttgtt gttgttgttg 1800
ttgttcactt gtggttctac attcctggtg aatgatgaat gttgctgtca aagggctgcc 1860
ccctacctta taagggttgc tgggcatttg aaggcaggaa gatttttaaa gatagattga 1920
ggttggttta aaattattcc tgtaaaccaa caataaagca aagaagaggt tcatttttgt 1980
aaataacact ggtttcaaat agtgatgtta gacttaacct aatttataaa caagagatta 2040
atatctccat gcatagtttt agacaaaaaa agatgtttca ataaaattac tgtcttgtaa 2100
tataaatgtt gtccacttcc cttttccaca ggcctagaac agttaaaggg aacataattt 2160
gtttaggctc ccacataaat gtgaatctgg ccaacaactt tggttcatcc tttagtgaat 2220
tagaggattt ggctaccctg agtatattta tattcatttc ttctgttctc cttctgttat 2280
tatacttaat cttctaaact aaactaatgt gaacagtagg gaagcaaggg cccaaatgca 2340
taagtttctt tgcactgttg cacttactta atacaaataa atgtttttta aagcttttgt 2400
agtatgtttt tatgagttaa catcctaatg tggtaggtat taggtaatgt gctgtcatga 2460
gaaaaattga gacttccaag aaaactggac accaggtgag ggttggtttg gagacggaat 2520
aggtgtagct gcctttcctt gaaaaacagt gtgtagagat ggctgagtgc aatggctcac 2580
acttgtaatc ccaacacttt ggaaggctga ggcgggagga tcagtatatc ggtacgtctg 2640
agcccaagag ttcaagatca gcctgggcag tatagcaaga ccccatctcc attttttttt 2700
taatgatttt ttaattaaaa aaaagaacaa caggatagag ctgttggggt ggcacagtgg 2760
cccaaagagc agcttcagag ataattcctt ggttctatga tccctgttta actccaaatt 2820
acagtcggac ttggatacat catttgtaac attgtaggaa agaaaaaagt cttggttgtg 2880
aaaaacgatt tgcatttggg taaaataaag tgaccatgct tttgttctgt aatactgtgt 2940
gacctgtggt tgttgtaatg gtgatcatgg agagcaaata tgaacttggc ctggatttta 3000
aatggcctag aatttgtggt agttgccaaa gaggttctcc taggtggtct taataaacct 3060
attcacagaa ttctccttaa 3080
<210> 46
<211> 2510
<212> DNA
<213> 人类
<400> 46
accccaacgc cgcttctgcg gccaaagtag gttgggagtg gaaggtggtg gctgctgctc 60
cgcagtgtcg ggaagatggc gccgccggtg gcagagaggg ggctaaagag cgtcgtgtgg 120
cagaagataa aagcaacagt gtttgatgac tgcaagaaag aaggcgaatg gaagataatg 180
cttttagatg aatttaccac taagcttttg gcatcgtgtt gcaaaatgac agatcttcta 240
gaagaaggta ttactgttgt agagaatatt tataagaacc gtgaacctgt cagacaaatg 300
aaagctcttt atttcatcac tccgacatca aagtctgtag attgtttctt acatgatttt 360
gcaagtaaat cggagaacaa gtataaagca gcatatattt acttcactga cttttgccct 420
gataatctct ttaacaaaat taaggcttct tgctccaagt caataagaag atgtaaagaa 480
ataaatattt ccttcattcc acatgaatct caggtgtata ctcttgatgt accagatgca 540
ttctattact gttatagtcc agaccctggt aatgcaaagg gaaaagatgc cattatggaa 600
acaatggctg accagatagt tacagtgtgt gccaccttgg atgaaaatcc cggagtaaga 660
tataaaagta aacctctaga taatgccagt aagcttgcac agcttgttga aaaaaagctt 720
gaagactact acaagattga tgaaaagagc ctaataaagg gtaaaactca ttcacagctc 780
ttaataattg atcgtggctt tgatcctgtg tccactgtcc tgcatgaact gacctttcag 840
gcaatggcat atgatctact accaattgag aatgatacat acaaatataa aacagatgga 900
aaagaaaagg aggccatcct tgaagaagaa gatgacctct gggttagaat tcgacatcga 960
catattgcgg ttgtgttaga ggaaattccc aagcttatga aagaaatttc atcaacaaag 1020
aaagcaacag aaggaaagac atcacttagt gctcttaccc agctgatgaa aaagatgccc 1080
catttccgaa aacagattac taagcaagtt gtccatctta acttagcaga agattgcatg 1140
aataagttca agcttaatat agaaaagctc tgcaaaactg aacaggacct ggcacttgga 1200
actgatgcag aaggacagaa ggtgaaagat tccatgcgag tactccttcc agttctactc 1260
aacaaaaatc atgataattg tgataaaata agagcaattc tactttatat cttcagtatt 1320
aatggaacta cggaagaaaa tttggacagg ttgatccaga atgtaaagat agaaaatgag 1380
agtgacatga ttcgtaactg gagttacctt ggtgttccca ttgttcccca atctcaacaa 1440
ggcaaaccgt taagaaagga tcggtctgca gaagaaactt ttcagctctc tcggtggaca 1500
ccttttatca aagatattat ggaggatgct attgataata gattagattc aaaagaatgg 1560
ccatattgtt cccagtgtcc agcagtatgg aatggttcag gagctgtaag tgctcgccag 1620
aaacccagag ctaattattt agaagaccga aaaaatgggt caaagctgat tgtttttgta 1680
attggaggga tcacatactc tgaagtgcgt tgtgcttatg aagtttctca ggcacataaa 1740
tcctgtgaag ttattattgg ttctacacat gttttaacac ccaaaaagct gttggatgat 1800
ataaagatgc tgaataaacc caaggataaa gtctccttaa ttaaagatga atagcatttc 1860
tttttggagg gtttagagat tcttactaat atgttgaact aaaatagaaa gaaaatgttg 1920
ctgtcatgta atttaaacaa tgtaaatatt ttatggaata atggcttttc aaatacattt 1980
cttaaggaac tgtttatgat tattactgga tttgtcattt ttgataattt aaatattgct 2040
gctgctttgt agatgatgag aagaaatgtt aaagtgcttt ctaaaaggaa attttttcac 2100
ctttggagga gaatatatta gagttgtggg taatttttca cagccaccta tgtacatact 2160
aattacccat tggatactta tatctaaaag tctcatgctg aagtatagtt tttgggaaag 2220
aatgatttta aataaagaga ttgtaaaagt aaaaaactgt aaatgtatat gtatgataga 2280
attgtttcct ctaagtgtag tttttctttc aactaaaatt cagtttatgt gtaaaataat 2340
tcagtcatta atagaaatgg agtgatttca cagtgtgtac tgttttgcca catacttcta 2400
aagaacacaa ttttatataa ttttgaaatc atgtatgttt aaattagaaa accaaaaatc 2460
atgaacattc taagagaaaa taaatataga atttaaaaaa ttaaaaaaaa 2510
<210> 47
<211> 4580
<212> DNA
<213> 人类
<400> 47
gggaggtggg actgactgag tcttccgtgt gtcgccgccg ttgccgcctc agcttcagcc 60
tcgttactcc tgcggttctg tgactgtgct gctggcgtta acggcgcgag gtgaagggag 120
gtgacggagt gtgcccgcgc gcgcgggggt cccctcagtc ccagcagttc ccttcgtgcg 180
cggggggcgg cgagggtctt cagcagtcgg gagaggccct tgacggcgcc atgtcggcgg 240
gcggtccatg cccagcagca gccggagggg gcccaggggg cgcctcctgc tccgtggggg 300
cccctggcgg ggtatccatg ttccggtggc tggaggtgct ggagaaggag ttcgacaaag 360
cttttgtgga tgtggatctg ctcctgggag agatcgatcc agaccaagcg gacatcactt 420
atgaggggcg acagaagatg accagcctga gctcctgctt tgcacagctt tgccacaaag 480
cccagtctgt gtctcaaatc aaccacaagc tggaggcaca gttggtggat ctgaaatctg 540
aactgacaga aacccaagca gagaaagttg ttttggagaa agaagtacat gatcagcttt 600
tacagctgca ctctattcag ctgcagcttc atgctaaaac tggtcaaagt gctgactctg 660
gtaccattaa ggcaaaattg gaaagagagc ttgaggcaaa caaaaaagaa aaaatgaaag 720
aagcacaact tgaagctgaa gtgaaattgt tgagaaaaga gaatgaagcc cttcgtagac 780
atatagctgt tctccaggct gaagtatatg gggcgagact agctgccaag tacttggata 840
aggaactggc aggaagggtc caacagatac aattgctagg acgagatatg aagggacctg 900
ctcatgataa gctttggaac caattagaag ctgaaataca tttgcatcgt cacaaaactg 960
tgatccgagc ctgcagagga cgtaatgact tgaaacgacc aatgcaagca ccaccaggcc 1020
atgatcaaga ttccctaaag aaaagccaag gtgttggtcc aattagaaaa gttctcctcc 1080
ttaaggaaga tcatgaaggc cttggcattt caattacagg tgggaaagaa catggtgttc 1140
caatcctcat ctctgagatc catccggggc aacctgctga tagatgcgga gggctgcacg 1200
ttggggatgc tattttggca gtcaacggag ttaacctaag ggacacaaag cataaagaag 1260
ctgtaactat tctttctcag cagagaggag agattgaatt tgaagtagtt tatgtggctc 1320
ctgaagtgga ttctgatgat gaaaacgtag agtatgaaga tgagagtgga catcgttacc 1380
gtttgtacct tgatgagtta gaaggaggtg gtaaccctgg tgctagttgc aaagacacaa 1440
gtggggaaat caaagtatta caaggattta ataagaaggc agtaactgac acacatgaaa 1500
atggagacct gggcactgca agtgaaactc cgctagatga cggtgcttca aaattagatg 1560
atctgcacac tctgtatcat aaaaaatctt attaaattga ccatatctcc agacaagatt 1620
gttaatcaga ctattctgaa tttggggcac tggggaagat ggtgacaaag actacaaaat 1680
caggggaggc tgtttgttgc ctaaatgaaa ggcgggtacc tcagggcttc atgtgaacaa 1740
ttctcaatgc ataaaacacc ctgttttctg tggtagacca taattagcta ttgcatgtaa 1800
agcaattttg attttcttga acttgtaagc accaaagcat gtgtttccca aaggggtatt 1860
actgggctct taagtaccaa atgaaaccct actgttttac ttggttcctt ttccctttag 1920
taggaggaca gtgctaactg gaattttata aggagtaccc tttaaaatac agagagtaag 1980
tgaattcata ttttatattc tagaatgtta actgtggtat ttcagaagac agagcttgac 2040
tcaatgaatt gtagaaatat aggcttgact taatttttgt aactgaaagg ctttagactt 2100
aaaaaaattt attgtgcatc ctaaaatcta aaccaattat taatgatcat ttattgtaat 2160
gagtttgcat ttcagcttta ttcaatgcag tacaaaatag ttttctttaa gcagtctttt 2220
atcaatcaat gctgcactag aaatagattc tcaaaagtta ctaaacattt tacttttttt 2280
gttttttaaa agaaatgcag atgagtgtaa aacatctgtt ctcaattatg ttgatctgtg 2340
tgcgcagtac tggagcattt acccattcat gttgagcctc aaatgcttgt tttctggggt 2400
ccacaaaaga cagttttata cattttgagt tgttcataaa gtttgtcttg tgatagtcct 2460
ggcacttaaa gacaaatttt tctggtagta aaagttcaga tttattacta tgtcatgaaa 2520
cacagtacat tcaaatcaaa cggcagtttt ctttctaagt aaatgatttc cagtcatcta 2580
aaaggtgggc aagatgagat aaagacattt tgatacagta attgttttgg ttgggttttc 2640
atgtcagttt atgtttgact aaagctctct tcatatgcag gtttataaat ttgttaggtc 2700
tgttgtccca tgattaaaca tggagtgcct cctctctgat ttaatattct gcaggtcatt 2760
gtaacctgct aggcaaagtc acaacattgc attaaagagg tgatagcttt gctaatatca 2820
ctgttttaaa ggacgtacag ttaaaggaat attaagtggg agaaagccta caaggctttt 2880
agaatattat cagtatcttc atttctggta ttcagatgtt atgtgataaa acacattttt 2940
tttggctttc ccagatacac tatatatttg ttcaagggta aatctataaa atgtatatac 3000
tttattttgt ggttttgcta tttataaatt taatgtttta actgttgctc atttatggtt 3060
tgttttgggt ggtggtgttc atctgtatat caccatgtta atttgtaatg gaagtgcact 3120
tcgtagtgta tattgttact gacattaaaa tactttatag cattgtctct gagcaaaagc 3180
tagtatttaa ttgtacaaat gaataagcaa gttacatgtt attgtttgct cttgacaggg 3240
taggcctctt aaaagaaaaa aaacaacttg ttttttcttt atgaatcccc tatgccaaac 3300
acataccttc catgcatgac atgagatctg caaactggat tttagccacc gtatttattt 3360
agtcaaaaaa attgtccatt gtagcagacc cgaaaacctt tttgctgtga catgaaacca 3420
tgttattctt atcttcttaa aacacagcct gggatggaat ggccatggca tttttttcag 3480
agaacatcct ttatctgcta tgactgaatc cttaggaaat gtaagctata accctttgat 3540
tttcaagaac taccgaataa gtgtatgaag aggtggtttt ttaaaacttc aagttggaat 3600
ttttatgagg tcactgtgta atttgaagaa ttgtgtgaga ttgtcatgat ataaattcct 3660
tttaaggact gataaataga atgaaaagtt tccaggtagt ttaaaactcc acaggtcagt 3720
ttccttttca ttcctgcttc actgtggttt ataagcctac gggagagcac cgttgctcag 3780
atgctactgt gagcttcctg tccggtgtta gaaagtaact agttaaaagt tcattttaga 3840
atgtatggtt tttggggatg aactaagaat tagttattag ttccaaagga ctgagaacca 3900
attttaatat tttcacattt ataggaaaga aattcatatg tccctgaaac ttctaggaca 3960
aaaccaaaca agtaaggagg gaactgttgc aaagccattt catcgagaag gggacagaag 4020
gagaaataca cacatgtata cacaaacaga atggttgaga aaacgtttta ataaaatgtg 4080
agggttgtat gtgtgcgtgt atatatttac acttaacctc taaaattctc ttctacagta 4140
tctctgttat gaatatgatg gaaaagcaac attttggtgg tgagactatt gttaaaataa 4200
atttgagaaa gacgaaaatt ttgtgagtct tgataattac aagtcaacag ctatcgaaag 4260
ttagcacagc ttgtctgtgg tgctgttttt ttccccactg cagtggactt atgctgtttt 4320
catgtttaga aacaaaaagg tttcatgtga ttcatgtgta agatgcacag tatttgacat 4380
cctgattatg taatccctat tccatctatc cagtcttaca cttatggttg gcctcaaatc 4440
tattgcattt atgataatgt attatatcta gttgagttta atattttttt attagcctgt 4500
aaataaagat ggcatcttct acattaaaat gatattgatc tcattttttt aaataaacat 4560
tttgtttcct tgacgttaaa 4580
<210> 48
<211> 2220
<212> DNA
<213> 人类
<400> 48
aaccggaagg ggggctgtga ggacgtgttc cgaggaagcc agagccggag ccgtggcctg 60
cggggccggc gacatggatc ccctgttcca gcaaacgcac aagcaggtcc acgagatcca 120
gtcttgcatg ggacgcctgg agacggcaga caagcagtct gtgcacatag tagaaaacga 180
aatccaagca agcatagacc agatattcag ccgtctagaa cgtctggaga ttttgtccag 240
caaggagccc cctaacaaaa ggcaaaatgc cagacttcgg gttgaccagt taaagtatga 300
tgtccagcac ctgcagactg cgctcagaaa cttccagcat cggcgccatg caagggagca 360
gcaggagaga cagcgagaag agcttctgtc tcgaaccttc accactaacg actctgacac 420
caccatacca atggacgaat cactgcagtt taactcctcc ctccagaaag ttcacaacgg 480
catggatgac ctcattttag atgggcacaa tattttagat ggactgagga cccagagact 540
gaccttgaag gtggggtccc tgctggggga cagagagaag gcctcttgtt ttagcctcat 600
ccaacagttt agtaactgtg tttatatttt gattacgtgt cctcaaattg tgatattttg 660
atgacaagac agagcccttg agtttgggat cctttctgtt ggagttgagt tattgtgagc 720
ctgaaagtac ccagttcctt tgccagtgct tgaaacaaac catgaagtgg cctctcttag 780
gatccaggtc ttttcccatt tactgaactt atcatgaaag tgagtgctac tacgaggggt 840
ccaatcacag gctgagaaat tgtgttacag aatctactct tggaagaatg aagacgtggc 900
tgtcctttgg tacctcgctt taaggtggct ttcccttagg acccctactg tggactgcct 960
tataactaaa accttttgta ttttagtaac tgaatcccca ctgtgcagtg ttagggctgc 1020
ctggttgttt gcagtagatt agagctttag aagcttctag agcttctaaa gcccgtgctg 1080
gtgatcccag cgactcttca ctccctagcc ttaggtattc ctagaagccc tgaccagttg 1140
gcactgctga gactccagcc cctgggagtg gtttacagaa acattacaca gactctgatg 1200
tcagtcatga tgtttcagcc tctgcccttt tcctgtatca accctgatgg ataatagggc 1260
gtgggttctg tctgttatca gggtgtggtc ccctgtgaat gaagcactcc cagccactga 1320
gctgtgagaa acagtcactc ggaagtgtga gctttatctt agtttttgtt ggatcatgtt 1380
gagtctgtca gctccacagg acttcagtac gtttctgaac agtccctgcc atctctacgg 1440
gggagagggt caggcaagct gcaagtgaca ctcacctcct gctgacagtt gcagtgtctc 1500
agatggcctg gaagggtggt ctccagcagc ctgctgggcg ctcccctttc atgagagcca 1560
cctgcagtga cctgaactga tacatgttga ttagtctgcc ctttctttag aaaactgcta 1620
ctctcctttt catatctcag aaaaacagta gaggcctttt aggaccaaac tccatgtcac 1680
actgatgaag agccagtggg ggttagagcg tcctgttaag gcacatgcta acttcccact 1740
caagtctggc agcgctgggg catcagcaca cctcttgcca cccacactga taccagaggg 1800
gaaggctgtg aggtggctgg gggttgagac ttgaggtttc taactttcct ctgcacacct 1860
gtggctacct ggtgtttgtc tcttgattcc ctccacctgc ctcacaccct gcctccgtcg 1920
ggattttcca cctacaccat tcaaaaggaa cataggagag ggcatgaagg ggctaggctg 1980
aagcactctg atgactgggg ccaatttgtg gctgaaaatg aatacatttt ttgaaattta 2040
tggtcatttt caagtgattt agaaggttga tccttagcct catacagtga tgaaataatc 2100
tgtgtgttca gagccaagca ggactttagc aagagtctga ttgtattgtc actatctcgg 2160
ggaaaaaaaa atacaaatac atttctctga tctctgatgg caatgaagtt tgacttgtaa 2220
<210> 49
<211> 4950
<212> DNA
<213> 人类
<400> 49
gagctgcagt cagatccggg gatggaggga gccggagaag aggagtgaga aggccgggga 60
ggcaggccct gctgtcttcc tgcaggccgg cagcctgctg gcagtggagg accaggccgt 120
ccaggaaagg aaggggtcag gaggtcgggc agggcctcag caggttcaga caagtcccca 180
gaagggagct gcaggcgccc tcgagtccag gccccaagcc tggctccggt tgtccaaaga 240
gggcctaggc caggcctctg gtgcggaaac tgagtcacag ccagacctca gggcacggcc 300
tagacgctta cgagccaaag ttaggggtag agagcagaga cctccggggg gtctcaggga 360
gtagggggct tcagggcctc ccagtctaga gccggattgg cgagttagac gcttgtagat 420
ccaaggttgg attggggtgg ggtctctggg acgttggatc gctacgcaag gattgggggg 480
attcaagtgc ttagagatcg aagtctgccc tgggtagggg gagtcagaca attggaaagc 540
ctaggtagtt atttggggag gggtctctac gccttggcga agcgcacagc tgcatctttt 600
tggcttgagg cctgaggcct tgtcgagaag cttccgtgaa agggtgggcc agccgggcca 660
cgagaaagaa agtgaataaa tcaggaatat aagtgggcgg ggggcccctg agaggggggt 720
cgcaaagggt gagacatggc caccaggcgt ttaaccgacg ctttcttgtt gttgcggaat 780
aattccatcc aaaaccggca gctgttagcc gagcaagtga gtagtcacat cacctccagc 840
cctctgcatt cacgtagcat tgctgcggag ctggacgagc ttgctgatga ccgtatggca 900
ctggtgtcag gcatcagctt agatccagaa gcagcgattg gtgtgacaaa acggccacct 960
cctaagtggg tggatggagt ggatgaaatt cagtatgatg ttggccggat taagcagaag 1020
atgaaagaat tggccagcct tcatgacaag catttaaaca gacccaccct ggatgacagc 1080
agcgaagagg aacatgccat tgagataact acccaagaga tcactcagct cttccacagg 1140
tgccagcgtg ccgtgcaggc cctgccgagc cgggcccggg cctgctccga gcaggagggg 1200
cggctgcttg ggaacgtggt ggcctcgctg gcgcaggccc tgcaggaact ctccaccagc 1260
ttccggcacg cacagtcagg ctacctcaaa cgcatgaaga atcgagagga aagatcccag 1320
cattttttcg acacatcagt accactaatg gatgatggag acgataacac tctttaccat 1380
cggggtttta cagaggacca gttagttctg gtggagcaga acacactgat ggtggaagag 1440
cgggaacgag agattcgcca gattgtacag tccatttctg acctgaatga aatattcagg 1500
gacttagggg cgatgattgt agaacagggt acagtccttg acagaattga ctataacgtt 1560
gaacagtcct gtatcaaaac tgaagatggt ttgaaacagc ttcacaaggc agaacagtat 1620
caaaagaaga atcggaagat gcttgtgatt ttaatattat ttgtcatcat cattgtgctc 1680
attgttgtcc tcgttggcgt gaagtctcga taagtggcat tgggttttcg tgtgtgccgc 1740
gcgtgtggat ctcccgggtg tgaggggctt ggcctgcgcc ccgccagctg cccgcagagg 1800
tgcagcctcg aggaatctga gggcgtcggg gcagcgaacc tttgcatcca cggactcctc 1860
cttccctagt cctgctcaag cggtccgggg aatgggtttt tgtttttcct tcattgttga 1920
gaatttaagg acctttgata ctgctgcaca atagagattg agttctggga tcagttataa 1980
tatatatttt ttttagaaag agaaaatgag ctgagagttt acaggcactg cagaagctgt 2040
tcagtattat atgtgtatat gctatttttt tagcagccat gtctgagcag aatgttaaca 2100
taatttttgg aaaaattttc tttaaaccat ctggttttta agaaatttgg taccaaaaat 2160
tgatgagtag aggcaaaaat gccccttcat ctttctctat atattttcca gttgaaaaca 2220
aactaagaag tcctttaaga atttataatc cgttccccat taacttaatt tagcttttcc 2280
atcactgtta atgatcagag taacaaagtg tgaaaaataa gaaaccatca ttgatgttaa 2340
ttaacacatt tagatgggcc agttaaaaca gcttcataag ttttaaatta attgtaaatg 2400
gaatattcct catttaaaat ttttgcactg cattttctac tgtaaaccaa aagaggttac 2460
taagcaaaac cacctaaatt taagttggtg atttaaatga atctcacatt aaaagaaagc 2520
ttgacagtgt tatgaaagcc accagactca gccagtgtgt ccccatgggt atccccagcc 2580
atccttgctc aatccattac ttatatacta actacataat gacctgttca aaccagactc 2640
tatttaatga actgtgaatt tacacagagg ccattttaaa tgggtcaccc catttaggat 2700
tagtggatct caaattatta accaaacatc actccatttc aaagtaaaat attccaccag 2760
cgatttgatt tattggctct tccattgcca ctgagcaatg cccaggaagc aggcacattg 2820
ccaaggactg ggggcatctt gactaggaag ctcctcgttt gtgtgagcgt gggtcagacc 2880
gccaaagtag gacttcatcg tttacctacc tattatcaat atggtgcttg aatatattcc 2940
tataactgta gaacagtgtg gaaagtgatg gtaactttga agttgttcat gttttattgg 3000
ctttgtttta attgacacta gtagagtttt aatggtcttt gtgtaaattt taatggcttt 3060
tccattgttt ttgcttctct taaaaagttt aagaagaata tgacctcatt aaatgtgctg 3120
ttttatttgg accagtcaca caaaatgtct ctctagagtt gactttaaag ttgtttacag 3180
aaatttaaac tcaattccag agattgaagt tgtccaaaca gctcatgggc ttagtgtcca 3240
aacccctgcc cagccttccc tttccaagtt ggtgccacct ccaggtagcc attggtggtt 3300
ttcctattac tgatgtggct gtggaatgat aaggtcctag aggggccctg gcatttcagg 3360
aagcggacct ggtattccct gacaaacatt gcttaggaaa gagggccgga gaataagaag 3420
ccagcacctc atcagtcagc cctgcaatgt gagacttccg tagctgttga gagtcactgc 3480
aggtgttctt tcatcccatc tgattttaac ccatggttga gacgttccaa gttagatctg 3540
ctgctcttag gtgtggggct gtccacatta gggaacttgc ctcaaaaaca gtccacagtg 3600
gcaataccgg acttctgttc aagcttttta aagtgctgag ccttacaaac ccctgaagga 3660
aggtgaccct ttaagagagg atcatctttt tttatattta ttttcaccaa atagggtgat 3720
gagggttggt ttttgttccc tcaacccatt tgggtaaaat aacggatctg attagaaact 3780
gttttaagga ggggctgggc tcggtggctc acgcctgtaa tcccagactt tgagaggcca 3840
aggcggtcac gaggtcagga gttcgagacc agcctagcca acatggtgaa accccgtctc 3900
tacaaaaaat acaaaaatta gccgggtggg acacgcctgt aatcccagct actcaagagg 3960
ctgaggcagg agaatagctt gaacccggga ggcagaggtt gcagtgagcc gagatcacac 4020
cactgcactc cagcctgggt gacagagcga ggctccgtct caaaaaaaaa aaaaaaaaat 4080
tgttttagcg ctgggtttcc caaggtggga gagacagacc cagcctggag ctggcccctg 4140
gcctgtgtgc tgacttcttg gggtcctcaa accactgtat ttttctgttg agcctgtact 4200
tggggagaga tcagtagcat ttgaggaagt aagagaaaag aatcatggta cctcagggtt 4260
tctttccctt tactcgctgg cagccattgt ctgtgggcac ctcatgtttt tccacactct 4320
actgggccgt ggaggtaacg atcacccagg ccagtctcct ctgcctggga tgcgccctct 4380
gagaggaggc ctagcagggc aggctccctc tgggcatccc tggatgcagc ctctggacac 4440
atgcctcctt taaagtgtcc gggtgcagct caggttgagt ggaggtagaa ggagaaacag 4500
acatgtttac cacgcgtttt ccaaagctcc tgatctttcc caagattgta actgaaaact 4560
gctgtctctt gttttgttcg ttttgggggt ggtggtgctg gctgggccat gcttgtgaag 4620
tgatgtgtgt ctctgattta acggattcac tgttttctct gctaattgag agagcgttat 4680
ttacattatt tatttgtttt gacacaagtg ctttcagtgt tttatcctag ctaatggctt 4740
cttaaaggta ataaaaccct tccaacgtaa ttggtcagat aaaacttttt ttcttgtatg 4800
cttaaataaa gcaattagtg aagcacttct atccaaaatg acttttttgt ccttttttaa 4860
aaccaattta ctgttactgg aaactttttg tacaataaag caatcacgca gattaaagaa 4920
catcctgcaa tcctagtatt aattttaaaa 4950
<210> 50
<211> 2739
<212> DNA
<213> 人类
<400> 50
agtaagttcc agcgcagcta gaccgcgggg tagtcggcgc gaggcggagc ttggcagttc 60
cgtccacttc agccgcagcg tccctcgccg ggtgtctcgc cgcagcctcc ggagaggaac 120
agaccctcac tctctctgtc agaaaaatgt ctgctccagc tcagccacct gctgaaggga 180
cagaagggac tgccccaggt gggggtcccc ctggccctcc tcctaacatg accagtaaca 240
gacgactaca gcaaacccag gcacaagtgg aggaggtggt ggacatcata cgtgtgaacg 300
tggacaaggt cctggagagg gaccagaagc tgtcagagct ggatgaccga gctgatgcct 360
tgcaggcagg agcatcacaa tttgagagca gtgctgccaa gctaaagagg aagtattggt 420
ggaaaaactg caagatgatg atcatgctgg gagccatctg tgccatcatc gtggtagtta 480
ttgtaatcta cttttttact tgagaatgta ccaccccttc cctgttgtcc attgccatcc 540
acattcatgt cctctgccct ctgtttgctc tctcaacaca cttccccacc caccgtcctc 600
cattccagcc caggcttctc catcacccat tcctcctttt tcgttgcgtt catttgcact 660
ctgtccctca acactagaaa tgctgctcgt ggcacaatct aagtcattac ccgaagagca 720
acagctggcg cctcctccct gcctgctttt tctgtactct caagttcccc caaagcccca 780
aagagttgga ggccaaggga aggggcaggg aggggagtgg ctgaggcgaa gtacccatga 840
agctgcccag acttgggagg agaagagtat cggtgcccat ggtgacttct agaaaacctg 900
gccactggta ggagctaggg aggggctggg aagatggcag ctcactcagt actgcctggt 960
catgtggagc tttccttcct ggaccaggcc tggagagggt cctgggggtg gaccaaagtc 1020
caacttggtt tcagtgcagt acccttttcg aaagtaaaaa cttgtttttt gtagttattt 1080
ctaatctgtt cgtccaggat tttccgtgtc tttggggatc ttacaacttt actttgttct 1140
ccagaggcct ggagaacact tagggattgt gaaaatagca ggacttgttt ccatcctaga 1200
agcagtccca tgtgcttcta gctggaagga gctttctctt ctttacattt tctacagcat 1260
tctgtatgag ggcaccaaat aaatccatct agctggtagt tttatctagc caaataattt 1320
aacctagctc ccagttaatt gttggcataa agagagagat tgcctgttag ttatagagaa 1380
acagtgagtc aagtgcttaa tttgaaagta acaagctcag aggaagccac tccttgccct 1440
cgttaaagag ggtcctgttc ctctcttcct gttgatgaag gagcgtgagg gtgttagcag 1500
tgtgagatct ttggacaccc atggaatcct ttcctccaca ccacccgtgc acttgccaaa 1560
gacagggatg aggcaagtgg ttcttcctgg ggcccggccg atcctcagga tgcagagaag 1620
tcatgtagac ccaccagccc caccttgggg ggaggcgtgc cagcctgtgt caggtgtgct 1680
tgtgtattgc tgtgctgtca tggggccctc tccttgagag ccgcctctct gttcttcctg 1740
tagtatattc ccctttgaac caccctttcc tgtctgaatt ctactttgcc tcctttctct 1800
tcctcctctt tgcatggttt gtgtgtatag acagtggaac ctgaggatgg gatctgctca 1860
gcctatcttc ggggcaattg ctgagcttca ggatgggcta ttaatgtggg ataagcccag 1920
gtgcaagggg aggagggcag gctgggaaca gagcggagaa tgcccatggc cctttattcc 1980
ttcttccctc ggtccacgaa caggaagagg ctgaggccat gctgggcagg gtctggatgc 2040
ccactttcca tgcagcagca tttcattgct caaaaccatc cttcctttcc tttcgccctt 2100
gtttcccaca ttcccttcgt cctgcccaag ggcgggactg aagagctgga agaaagcagt 2160
cagtaccctc ccaacggccc ccctcgaagg tctccactct cctctgggct cctccttgcc 2220
taatgcaggg ggtcaccgct ggagaagaac caccactgtc ctcgatgtgt cccaagcctg 2280
gagcgaatcc gtcctcttgg ctctcccagc cctatcacag gaatcattcc tgggtttctg 2340
tccctctgag gctcaccagg tgtagttggc cttgttcttt gggggtatta gcccttctac 2400
tttctttctc acccaccctg taccctcttc tgtgtgtctc tgctatcccc ctttcctccc 2460
accacccatg tgcatgagca aatgtgcaac aaaaccctgg gactttgcag tcaaatgaag 2520
ctgagcttcc cacatcccgt tcttcggttt gccatgagac gatgtggggt ttccactgtg 2580
tgtctgtcat cacctctttg tctttttttc ctaaccctga tctcatactt gtatagagta 2640
ataacaacag ttgtacttcc accaaaggca tgtggcatat ttaccaatgt catgtattct 2700
gaacaaaggc aaaaaataca aattcctacc attaaaaaa 2739
<210> 51
<211> 2160
<212> DNA
<213> 人类
<400> 51
agtccttcag cggccgggtt cgcgccgcgg tcgccggctg cttacgtggg cgggcctagt 60
gtggggctga gggtgcgggt cgctatggcg gtggacatca cgctgctatt ccgggccagc 120
gtcaagaccg tgaagacgcg gaacaaggcg ctgggagtgg cggtgggcgg cggggtcgat 180
ggcagccggg acgagctgtt ccgccggagc ccccggccca agggcgactt ctccagccgg 240
gcccgcgaag tgatttctca cattggcaaa ctgagagatt ttcttctgga acacaggaaa 300
gattatatta atgcttatag ccataccatg tctgaatatg ggaggatgac agacacagaa 360
cgagaccaga tagaccagga tgcccagata ttcatgagga cctgttcaga agcaattcag 420
caactacgaa cagaagctca caaggagata cattcccagc aagtgaagga gcacaggacc 480
gctgttttgg atttcattga agattacttg aaaagagtat gtaaacttta ctcagaacag 540
agagccatcc gagttaaaag agtggtggat aagaaaagat tatctaagct ggaaccagaa 600
ccaaatacaa agacaagaga atccacatct tctgagaaag tttcacagag tccttcaaaa 660
gactctgaag aaaaccctgc cactgaagaa cgtccagaaa aaattttggc tgaaacacaa 720
cctgaattgg gaacgtgggg agatggcaaa ggcgaagatg agttatcccc agaagaaata 780
caaatgtttg aacaggaaaa tcagcgacta attggtgaaa tgaacagctt gtttgatgaa 840
gtgaggcaaa tcgaagggag agtggttgag atttccagac tccaagagat attcacggaa 900
aaggttttgc aacaggaagc tgagattgac agcattcacc agttagttgt gggggcaact 960
gaaaatatca aggaaggcaa cgaagacata agagaggcca ttaaaaacaa cgctggcttc 1020
cgcgtgtgga tcctcttctt cctcgtgatg tgctccttct ccttgctctt cctcgactgg 1080
tacgacagct agccagggcc acgggggccc agcacgagag tcctcatggg cactcacaga 1140
ctgcgtgctt tcatgtactt ccagtgctgg agcatggtat gaccagattt tatcacagtg 1200
ccatttgaag ggaaaggagt tcagacagac agacgtattc cccaaaaagg gataccccag 1260
gccgatggtg ttcagccatt tagcagctga aaaaggaaac agtgcacacc aatgggaggc 1320
agcctgcgta gccctcatca ggcaagacag actgaatgca ggagtgggtg attagctgct 1380
ccttgaactt gaggctgcct tggcagcagg ggcacagcag gcctcaagag cccctaattg 1440
tctcagggtt caaaggaaga cactgacctt tcccatcccg gtagcttcag ggaagatcat 1500
agttaataac gtctctcaac aaatgattac ttctttgttt ccttgtggct tcttgtctgt 1560
ctgagtcaac gaatacacag acttactgga ttatagaaga gaaaattcac atctgccttg 1620
ttaatctaat aaatataatt acagcccctt aatgtgttgt caatgagtct aagttgacaa 1680
attcagtggc agcccagcca cctcctatca atcaatcagg gaagaaatgc aggggagact 1740
ggggccctca gtgaggggct gcctggcatt actcctccaa agactgctgc ccccagaaca 1800
ggcagggggt gtgggagggc cagtttcccg ccactgggtc caaggagcct ttgttcaaag 1860
gaagaagtgg gccacggaag aacgggcctg cttctctcgt gcctgtgctt ctgacctcca 1920
ggaactgtaa acaggaacac ctatgtgtaa ctgaaggcat gagacatctg tacaggaagc 1980
atcccagcgc ccacatgggc atgagacagt ctgcactgcg cctggtgaaa tgcgtgtgtg 2040
tacagacagt ccactgggca gcacaggtat cctcatgttc tttatttgca cagagtgaaa 2100
tgtcagaagt tacatgtaaa tgaattcaca gtcaataaag tccacgtcta cctggaaaaa 2160
<210> 52
<211> 3330
<212> DNA
<213> 人类
<400> 52
gcagagcgcg cggggcgcgg ttgccgtggc agcgccggct ccagggaggg ctgctggcgc 60
cgggccggga ccgcggggcc tgaggcggag accggagagc ccgaggcccg gccggaggca 120
gctcgggaca ggcttgagcg gcggggcgcg ctgcccggcc ggcggggatg cgggaccggc 180
tgccagacct gacggcgtgt aggaagaatg atgatggaga cacagttgtt gtggttgaga 240
aagatcattt catggatgat ttcttccatc aggtggagga gattagaaac agtattgata 300
aaataactca atatgttgaa gaagtaaaga aaaaccacag catcattctt tctgcaccaa 360
acccggaagg aaaaataaaa gaagagcttg aagatctgaa caaagaaatc aagaaaactg 420
cgaataaaat tcgagccaag ttaaaggcta ttgaacaaag ttttgatcag gatgagagtg 480
ggaaccggac ttcagtggat cttcggatac gaagaaccca gcattcggtg ctgtctcgga 540
agtttgtgga agccatggcg gagtacaatg aggcacagac tctgtttcgg gagcggagca 600
aaggccgcat ccagcgccag ctggagataa ctgggagaac caccacagac gacgagctag 660
aagagatgct ggagagcggg aagccatcca tcttcacttc cgacattata tcagattcac 720
aaattactag acaagctctc aatgaaatcg agtcacgtca caaggacatc atgaagctgg 780
agaccagcat ccgagagttg catgagatgt tcatggacat ggctatgttt gtggagactc 840
agggtgaaat gatcaacaac atagaaagaa atgttatgaa tgccacagac tatgtagaac 900
acgctaaaga agaaacaaaa aaagctatca aatatcagag caaggcaaga aggaaattga 960
tgttcattat tatttgtgta attgttttgc ttgtgatcct tggaattatc ctagcaacaa 1020
cattgtccta gcaaccatat cccaagagcc atttatcctt gagactcaga ccacatctgc 1080
aaccaaatca gcatcctgtc atttcgtgaa tgaatctcag acgctgtaac ccggcatcga 1140
gtgctgacct tgtaatgtat gagttcacgg aagaagcaca accgaacgtc ttgttcagtg 1200
acagcgccgt aagcacagtg ggtgtgatgc gtgaccctga atgacacact acagaatgtg 1260
agcagtgtga gacttctctc actggccttg aaataagaaa atattgaaca ttttaatatt 1320
aaaaatattt cagtgttaac aaatgtgcat gaagtttaat taggaaggaa tgctttatgt 1380
tatgaaggct tttttttttt tttttgagac ggagtctcgc tttgtcatcc aggctggagt 1440
gcagtggtgc gatctcagct cactgcaacc tcggcctccc gggttcaagc aattctcctg 1500
cctcagcctc ccgagtagct gggattacag gcatgggcca ccacacccag ctaatttttt 1560
gtgttttctt tttagtagag acggggtttt accatgctgg ccaggctggc ctcaaactcc 1620
tgaccttgtg atccacccac ctcagcctcc caaagtgctg ggattacagg cgtgagtcac 1680
cgggcaggct gttctgaagc ttttagatct caggtctaag gcttcctttc cctccctctc 1740
ccagctagtt tgtgctaatt aagagacctt ttatactgtt ttattgcctg tttgaagaaa 1800
taatttttat cacgtttttg taagatatct ataattttaa atgtttataa attgtttaat 1860
ttattagcat cttaatgtac cccattttta tatactgaat gtggcctttt gagtgaaata 1920
ggaagcttca tggtgttgga gccacctttg tacagttgtt taaagtttcc cattgtcacg 1980
gaaaacattg gctgcaaagc ccctcaaagc cctcaagtgc cttctgtgag tttaaatgtg 2040
ctggtgccct ccagaaaagc ctcggcctca gctccgtttc cgcctgttcc ctcccccagg 2100
ataatgaatg gttactgcac tgtaaagacc gtggtctctt ttcactaaat aggagattcg 2160
agtttcccag tttacatgaa tgaagtctga atttaagacg gtgatgaaac tgaggttcag 2220
tactctcggg actcgaggaa attattcctg agacatggag taattcttac aaatttaaac 2280
tattgtacag atccacatac atgttgttaa gtacctaatg ttttgctgaa cttttaaaag 2340
ttaatttcca aaatgtatag ggattcatga taattaaacc tttttattgc tcattttttt 2400
agtagaagaa tatcacttat ttttagactt gtaaaatgta tgaactggtg agcggacatc 2460
tgttaagaga gtcactagtc agaatgttaa aggagtgcat gcaggatgcc ccaaatgtcg 2520
tgaactcttg ttactcctgt atgtagtagt gtaagcatgt gacttttaac accatttggt 2580
ttgaaactaa tgtagagatg cctgattcca aacaggtgtg gagaatattg aatggctcag 2640
aagccgcgtc ccttacttaa cacaattccg aatctccctc atccatgatg cgtccattgg 2700
atcactcgct ggtggtcact gtgtggcagt tactagggga attctgcctc tgactgttct 2760
ttttcttttg gtctttaaac accctgtcgt gggatgtgct cactgatttg tggctatgtt 2820
gaaggtatca cttgtcttga gggttttcaa tatttcagga tcatgctggt ggcaaaagga 2880
ctccacgcct ctgtggaatc atgtccacag ggggacctgc ctcccgtgat gtcccacctt 2940
tccttcaagg tctgtcatat gagtcctccc cttttacaac acttattatg gtatttttca 3000
agttattctt cttagatttg cagtacctac tgaaatttgt gtttttatag ttgaagttag 3060
gaaaatgcta tttgatttgt atttagatat ttaagtcact tgtccaatga tgtgtatgtc 3120
taagcctcat gtaccgattt gaagtcagac ttaaaaatgt atttacagat tcacttgaga 3180
ctttttaatc ggttcttcaa atatttcatg tttacattaa aaatttccag agaagcataa 3240
aagtattcac tttcctgcct tgtcatttct ggaaagattt tggggagata ttttattgca 3300
tattaattaa taaattgttc tactaggaaa 3330
<210> 53
<211> 2940
<212> DNA
<213> 人类
<400> 53
gcgcggcgga ggctcccgtg gcctcggacg ctcctcctag ctagcggccg ccgcccgccg 60
ccgcctgcgc ctccagctcc ttcgccccgg cgggcccggc cgccgcttcc ggcagctcac 120
ctgggaagcg ctcacctggg acgcgctcac ctgggacgcg ctacctgcct ccgggcgcct 180
gggcttcagg atgaaggacc gtctggagca gctgaaggcc aagcagctga cacaggatga 240
tgatactgat gcggttgaga ttgctatcga caacacggct tttatggacg agttcttttc 300
tgagattgag gaaactcggc ttaacattga caagatctca gaacatgtag aggaggctaa 360
gaaactctac agtatcattc tctctgcacc gattccagag ccaaaaacca aggatgacct 420
agagcagctc acgactgaga ttaagaaaag ggccaacaac gtccggaaca aactgaagag 480
catggagaag catattgaag aagatgaggt caggtcatcg gcagaccttc ggattcggaa 540
atcccagcac tctgtccttt ctcggaagtt tgtggaggtg atgaccaaat acaatgaagc 600
tcaagtggac ttccgagaac gcagcaaagg gcgaatccag cggcagctcg aaattactgg 660
caaaaagaca accgatgagg agctggagga gatgttggag agtggcaacc cggccatctt 720
cacttctggg atcattgact cacagatttc caagcaagcc ctcagtgaga ttgagggacg 780
acacaaggac attgtgaggc tggagagcag catcaaggag cttcacgaca tgtttatgga 840
catcgccatg ctggtggaga atcagggtga gatgttagat aacatagagt tgaatgtcat 900
gcacacagtg gaccacgtgg agaaggcacg agatgaaacg aaaaaagctg tgaaatacca 960
gagtcaggcc cggaagaaat tgataattat cattgtgcta gtagttgtgt tgctgggcat 1020
tttagcattg attattggac tttccgttgg gctgaattaa gagtggccta agaggctgct 1080
gcactgaaat aaactgattt cactccagac tggtgtggcc acccttgtct tcagatgaga 1140
atggagtctg aatggccttc ctgagagcga gtgcgacccg ttcctttgtt tccttgcaac 1200
cacccttgga cctgactcag ctaacaatct agccctgggg gaatgtgatc tacctgatgc 1260
gaccctgagt tctccccaga gcctcctcct gccccaccag ctctcaagta ccttttctcc 1320
tggactgtgt ggacccaccc agctttcttc ctccctgttg tgtgtcagat tatgccttgc 1380
acttgggaaa gctcttgtga gactctccca aggtgctgta tttttctacc tcatggagta 1440
ttctcccaga aactgcaatg tattttttta ggggagtatc tttaacaaag cagaatgatt 1500
cttctaagtt tggcaacaag aaggcttgga tctgagtctt ctacctggca ggatgccaat 1560
cctgtttgtt gtccgtatgt cctgaaaaca tgagggactg gcagatgtca ttttggtcta 1620
aagagctgac ttgtttgaaa ttcagcctta aattaagctc ttagttgttc agcttggggg 1680
gcaactttga tttttctctg tgttgtagtc tctcatattt actcaaggag ggaccaggat 1740
gatacagtca tctgaggtta tgctttgcaa aaggctgacg gtatggaata tgtttccatg 1800
tctgagtctt agaaactggc tgctcattgt tagaaagtga tgctttgtga gactattgtc 1860
ttggggccaa aaataatcag ggattttaaa ttgggcaagg gacaaggtgc tagaatccta 1920
agctctggaa atatttcatg acactggtgt attcactcat gtgttccaga tgtattctaa 1980
ttgtgtatga aatgtatgta cacataagtg tgtgtgtctc aggaagtagg aaataaaaat 2040
ggaagctatt atgacctcaa aaaaaaaaag ccaactttga gctaggataa aaattgggta 2100
aaggacattt gcttacctgc aaatgaatca ctgtggaaat gtgatcttcc catatcatca 2160
agaaacttgt tttctggatg aatactggga gaataaaatg agaactctgg agtgagctaa 2220
attgatccca attaagtttt tctgcttagc agacagaagg tataattttt tgacaccctt 2280
tcccacctgg tgcctatgct aggcttgtcc tgagaacatc cctcagtaac ttgatattca 2340
catgacctac aggatgtccc atctgcaggg ctgagtcagt tggggaacac cagaggctac 2400
acagtagctc ttcctgctac tcggttaatg agcttggcag gttctttgtc tcactgaatt 2460
cttatcatgg aaacagcagc agcagccgct aggaaatctt caagtgtagt gtctgtgcta 2520
acccagtggt aaatccctta gatcccctgc tggtctctgg cagtctcctt gattttgggt 2580
accatgtata ttttccgctt tgactttaac gctttctagg atagggtaag cacccttaat 2640
tcaggcactg tccattagct tcctttgcaa aggctactta tggccggtca caatccagca 2700
ctcagacaga gccaaggcaa tatcctcttg cccatggcta tgatgtcaga cagtggatgg 2760
gctccagcaa caagagacaa aataactaaa ggcctttgct ctcctctgac attgaggcct 2820
ggggcttaca gtttggaata caacatgtga aggtttttgt tgttgtttgt attttttaga 2880
tgtaaacttg attattttat tgctaattta aaaataaaaa tgactttgta ttgattgtga 2940
<210> 54
<211> 4820
<212> DNA
<213> 人类
<400> 54
agcggaccgc cgcggcccgc gctgtaaccg cggctgccgc tgctgctccg ggcgggcgtt 60
ggtgccgtgt gccgaggcgc cctgtcaggc gatggggagc ggctgggcgg ggagagccga 120
cggccgcggc ggcgcctgag gaacgcagcc gggctcggga gcggcgaggg cgggccggtc 180
cagcggcgga ggagcgaggc ggggcgaggc aggcggcgcg gggacccgcg ccaagcagcg 240
gcggcctcgg aggaagaggg gtcgccgccc aggtttcttg cggccgccgc tcttgtcgtc 300
gcagtatttc ctgttcggat tatcttttgc ttccccccag ctgcctcctt accctcacac 360
tcccactcct ccgtttccgc ggtcgaagct gccttcggcc ccgggtggtc tcccccgccc 420
ggggaccccc tgtgcctccc ctcccgggct gcgggggagc ccctccgaga ccatgaggaa 480
attcaacatc aggaaggtgc tggacggcct gaccgccggc tcgtcctcgg cgtcgcagca 540
gcaacagcag cagcatccgc ctgggaaccg ggagccggag atccaggaaa cgctccagtc 600
cgagcacttt cagctctgca agactgttcg ccatggattt ccctatcaac cctcagccct 660
ggcctttgat cctgtacaga agatcctggc agtgggaact cagactggtg ctttaaggct 720
ctttggtcgt ccaggagtag aatgttattg ccagcatgac agtggagctg cagtaatcca 780
gctccagttc ctgattaatg agggagcgct tgtgagtgcc ttggctgatg acaccttaca 840
cttatggaat ttacgtcaga agaggcctgc catactacat tcgcttaaat tttgcagaga 900
aagggttaca ttttgccatc tgcctttcca gagtaagtgg ctctatgtgg gcactgaacg 960
aggtaatata catattgtca atgtggagtc cttcacactc tcaggctacg tcattatgtg 1020
gaataaagcc attgaactgt catctaaatc tcacccagga cctgtggtcc atataagtga 1080
taatccaatg gacgagggaa agcttttgat tggctttgaa tctggaacag tagttttatg 1140
ggacctcaaa tcaaagaaag ccgactacag atacacatat gatgaggcta tccactctgt 1200
tgcttggcat catgaaggaa aacaatttat ttgcagtcat tcagatggca ccttgactat 1260
atggaatgta aggtcccctg ctaaaccagt acagacaatc actccacatg gaaaacagtt 1320
aaaggatggg aagaagccag aaccatgcaa acctatcctc aaggtggaat tcaaaacgac 1380
tagatctggg gagcctttta ttattttatc aggaggtttg tcatatgata ctgtaggaag 1440
aagaccttgc ttaacagtga tgcatgggaa aagcactgct gtgctagaaa tggactattc 1500
aattgttgat tttctaacgc tgtgtgaaac accataccca aatgattttc aagaaccata 1560
tgctgtggtt gttcttctag aaaaggattt agtacttata gaccttgcac aaaatggata 1620
tcctatattt gaaaatccct accctttgag tatacatgag tcccctgtta catgttgcga 1680
atattttgcg gattgtcctg tggaccttat tcctgcactt tattctgttg gagctagaca 1740
gaaacgtcaa ggttacagca aaaaggaatg gcccatcagc ggaggtaatt ggggcttggg 1800
tgctcaaagt tacccagaaa taattattac agggcatgct gatgggtcag ttaagttctg 1860
ggatgcttct gcaataactc tacaagtatt atataagcta aagacatcta aagtatttga 1920
aaagtcaaga aataaagatg acaggccaaa cacagacatt gtagatgaag atccatatgc 1980
cattcagatc atctcctggt gtccagaaag tagaatgctg tgcatcgctg gagtttcagc 2040
tcatgtcatt atttatagat tcagcaagca ggaagtaatc acagaagtca ttccgatgct 2100
tgaagttcga ttattatatg agataaatga tgtggaaact ccggagggtg agcagccacc 2160
acctttgcca acacccgtgg gagggtccaa ccctcagccc atccctcctc agtctcatcc 2220
atctaccagt agcagttcat ctgatgggct tcgtgataat gtaccttgtt taaaagttaa 2280
aaactcacca cttaaacagt ctccaggtta tcaaacagaa ctagttattc agttggtttg 2340
ggtgggtgga gaaccaccac aacaaataac cagcctggca gtcaattctt cctatggact 2400
ggtggttttt ggcaattgca atggcattgc tatggttgac tacctccaga aagcagtgct 2460
gctcaacctg ggcactattg aattatatgg ctctaatgat ccttatcgga gagaaccccg 2520
atctcctcgt aaatctcgac agccttcagg agccggtctg tgtgatatta gtgaagggac 2580
tgttgttcca gaggatcgct gcaaatctcc aacctctgca aagatgtcaa ggaagttaag 2640
cttacctact gacctaaagc ctgatttaga tgtaaaggat aactccttta gccgatcacg 2700
gagttcaagt gtaacaagca ttgacaaaga atcccgagaa gcgatctccg ctcttcattt 2760
ctgtgaaacg tttactcgaa agacggactc gtccccttcc ccttgtctgt gggttggaac 2820
aacgctagga acagtgcttg tcattgcact gaaccttccc ccagggggag agcaaagact 2880
tcttcagcca gtaattgtgt ctccaagtgg tactatattg aggttaaaag gtgcaatctt 2940
gagaatggca tttctggata ccacaggctg cttaatacca cctgcgtatg aaccctggag 3000
agagcacaat gttcctgaag aaaaagacga aaaggagaaa ttgaaaaaac ggcggcctgt 3060
ctcagtatcc ccctcctctt ctcaggaaat tagtgaaaac cagtatgcag tgatatgttc 3120
tgaaaagcaa gcaaaagtaa tctcactgcc aacccagaac tgtgcttata agcaaaatat 3180
tacagagacc tcgtttgtgc ttcgtggaga tattgtagca ttgagtaaca gtatctgcct 3240
tgcctgtttc tgtgccaatg gacatataat gacttttagt ttgccaagtt taagacctct 3300
gttggatgtg tattacttgc cccttaccaa tatgcggata gccagaacgt tctgctttac 3360
caacaatgga caagcattat accttgtttc acctacagaa atccagagac ttacttatag 3420
tcaagagacc tgtgaaaatc ttcaggaaat gttgggtgaa ctcttcactc ctgtagaaac 3480
acctgaagca ccaaacaggg gattctttaa aggcttattt ggaggtggtg cacaatctct 3540
tgacagagaa gaactatttg gagaatcgtc ctcaggaaag gcttcaagga gccttgcaca 3600
gcatattcct ggccctggtg gcattgaagg cgtaaaaggg gcagcatctg gagttgttgg 3660
tgaattagca cgagccaggc tggcactaga tgaaagaggg cagaaacttg gcgatctgga 3720
agaaagaact gcggccatgt tatcaagtgc agagtcattt tctaaacatg ctcatgagat 3780
tatgttgaaa tacaaagata agaagtggta ccagttctga caaccagaat ccaataagtc 3840
caacttcagc cagaaggaaa aaagttttcc atttttatta cattctttag gaaagttaac 3900
gttaaaggga tgttcgtcac tgaatactgt tctttcctag cacagtcatg cactgtttta 3960
cctcagtcat gtggctttaa ctgaggagtg ttcacacgca ctcgaaatgg agtatatggt 4020
gtgtgccagt tatgagttga ccatttggga attaaacagg tcacacgtga cagatgaaga 4080
aaccaagggg gctgctgagg agacctggtg cagggactaa tcctggatca ttcctgtatt 4140
aaactttcat atgccaaaag ggtttgtgcc gttttatctg ccatcagtgt ttgacctgtt 4200
tagggcagag gcaataagtc agaagtcttg aagttgaaat agttatatgt gtgtcattgg 4260
actggattat aaacagctgt cttggacttt ccctctctta acactgactg gtcatcagta 4320
tcattagtga aaaagaaaca aattgtttgt tatcatctct ttagacagat aagctgaatg 4380
gtgggcttta aataataaaa acatacacat agttgacttg tgtatgagct actcttggat 4440
tcttgttatt atagacttgt atttagttca tattttgtca aaagcaaaac aagaagatac 4500
atcacttttc attgaaaaga aaagtgtaga gcatgactga attgctcatc attctgggag 4560
tttccatgta gtggctatgc agtgtggaaa gtgagaaaaa cctccattgt ggtgaggaga 4620
atacttcaat gtcccttgtc cttgttctca ttaattcagc taaaggtgga tttgaccaaa 4680
ataatgctgg ttaaatttgt agaaatgttg aaattggctg tgttttaaat tttgcttgaa 4740
tttttataaa atgtttaacc aaatgtacct ttgcattctt taattaaaat tgcttaaaaa 4800
aaaactttca ttatttcagt 4820
<210> 55
<211> 2148
<212> DNA
<213> 人类
<400> 55
cgcgactagg gtgcagcgcc aggtccggtg ttggggtgtc cgagttgccg ccggagagga 60
gtggcctcgc ccgcttgagt tttgattcat catggataat ctgtcatcag aagaaattca 120
acagagagct caccagatta ctgatgagtc tctggaaagt acgaggagaa tcctgggttt 180
agccattgag tctcaggatg caggaatcaa gaccatcact atgctggatg aacaaaagga 240
acaactaaac cgcatagaag aaggcttgga ccaaataaat aaggacatga gagagacaga 300
gaagacttta acagaactca acaaatgctg tggcctttgt gtctgcccat gtaatagcat 360
aactaatgat gccagagaag atgaaatgga agagaacctg actcaagtgg gcagtatcct 420
gggaaatcta aaagacatgg ccctgaacat aggcaatgag attgatgctc aaaatccaca 480
aataaaacga atcacagaca aggctgacac caacagagat cgtattgata ttgccaatgc 540
cagagcaaag aaactcattg acagctaaag ctactgctgt tcttctttat catttattca 600
cttccgtagc tcctccttga aagttattac cttttcagag tttaagtttt cggttccacg 660
ctcttctaat tgggagataa tatggaagaa gggccagagc agttacagcc ctccttcttt 720
tttgttttct gttgagggcc gactgctgct ctgccttcct tctagtattt tctttctcaa 780
ttcatacgct tagattggtt ttcatatgtc atgtttagtg ttttcatcct cctcatatac 840
ttcagcaggt tcttttgctt tcaagatttg gaagcattgc caaagacagc catgaagaag 900
gaagctgtag aggtgttttt tgttgttgtt tatttttgct tttgtggttg agggaaggac 960
aagagataag aggttgttac ctcagtaaaa accttcaggc cacaaagcaa aaagttgcat 1020
agccacaacg aagatctagt tggatatagt ttttgattta agttgcagtt atagccaatt 1080
taggctaatg cttggttttg gagcttttat acacaacgtt tttgttaggc atcacagttt 1140
tgcaacctct gctccaaaga gaaaaataga atgagttttc tttctttttt ttttttttgg 1200
agtcagagtc tcgctctctt gtccaggctg gagtgcaata gcgcgatctg ggctcactgc 1260
aacctccgcc tccctggttc aagcaattct cctgccttgc ctcctgagta gctgggatta 1320
caggcgtgtg tcaccacgct cggctaattt ttgtattttt agtagagaca gggtttcacc 1380
atgtcaagct ggtcttggac tcctgacgtc gtgatccacc cgccttggcc tcccaaagta 1440
ctgggattac aggcgtgagc cactgtgcct ggctgagttt tcttaaagtg agcttaattt 1500
ctgaactctt agtgattcat atatgtacat aaatctgtga tcccatttct tattgcacca 1560
ttcaggaaca ctttatataa atgagtggct ttttatttca tattattagt agtatcatgg 1620
ttccattaca ggcctattaa catcatacat tgtcattagt ctttgaagaa aaaatatgta 1680
aatatatatg tgtaacatga gaatttctct ctaaagcagg gcttaaaatt ttttggaaaa 1740
gtttgacaaa gcataccaca tgaattcaga tttacctcaa tgctaagaat tatgtttagt 1800
taggaaaaag gaaagtcatt ttgacctcag gtagaaaaat agattgcttt gagttttatg 1860
tagctttaga ctttaaaaag ttagaattta ttctgtaact aaaaattatt tgaaaaaatt 1920
atgcctctgg tttaattatt ggtgattaca cactctttct cttacccttg tgtattgaac 1980
tatgtccata atcaagttga tgtggatcct gaaaagtgtt atgaacatct gattggtatt 2040
tgtcacattt attttaaaat tagcatctga acacttcaaa gctgtcagtg tgtattggtt 2100
tcaccaataa ccactgcttg atccttacaa ttaaattttt taactaac 2148
<210> 56
<211> 750
<212> DNA
<213> 人类
<400> 56
atgtctctcg aagacccctt ttttgtagtc cgaggcgagg tgcagaaggc ggtgaacacg 60
gcccgcgggc tgtaccagcg ctggtgcgag ctcctgcagg aaagcgcggc ggtcggacgc 120
gaggagctgg actggacgac caatgagctg cggaatggcc tgcgcagcat cgagtgggac 180
ctcgaggacc tggaagagac catcggtata gtggaagcca acccaggcaa gttcaagctc 240
ccagccgggg acctgcagga gagaaaggtg ttcgtggagc ggatgcgaga ggcagtccag 300
gaaatgaagg accatatggt cagcccaaca gccgtagcat ttttggagag gaataacaga 360
gagatactcg caggcaagcc agctgcccag aagtcaccca gcgacctgct ggatgccagc 420
gcagtctcgg ccacatctcg ctacatcgag gagcagcagg ccacacagca gctgatcatg 480
gatgaacagg atcaacagct ggagatggtg tctgggagca tccaggttct gaagcacatg 540
tccggccgcg ttggagaaga gctggacgag cagggcatca tgctggatgc cttcgcccaa 600
gagatggacc acacccagtc ccgcatggac ggggtcctca ggaagttggc caaagtatcc 660
cacatgacga gtgaccgccg acagtggtgt gccatcgccg tgctagtggg ggtgcttctc 720
ctcgttctca tcttactatt ctctctctga 750
<210> 57
<211> 1794
<212> DNA
<213> 人类
<400> 57
gggggtgggg ttacgtgtag gtgacgtggc cgcttccagt ctttggtcgg gtttcggcgg 60
cttcagtgct cggggaggag gcagtgacgg ccggtgagat tggaagtggc ggcggcggca 120
ggcggcagag gggagtccga ggttatgcgt ctcaatgatc ccgcggaaac gctacgggtc 180
taagaacacg gatcagggtg tctacctggg tctctcaaag acacaggtcc tgtcccctgc 240
aactgctggc agtagcagca gcgacatcgc ccctctgccc cccccagtga ccctcgtccc 300
tccccctccc gacaccatgt cctgccggga tcggacccag gagtttctgt ctgcctgcaa 360
gtcgctgcag acccgtcaga atggaatcca gacaaataag ccagctttgc gtgctgtccg 420
acaacgcagt gaattcaccc tcatggccaa gcgcattggg aaagacctta gcaacacatt 480
tgccaagctg gagaagctga caatcttggc aaagcgcaag tccctctttg atgataaagc 540
agtggaaatt gaagagctaa catatatcat caaacaggac atcaatagcc tcaacaaaca 600
aattgctcag ctccaggatt tcgtgagagc caagggcagc cagagtggcc ggcacctgca 660
gacccactcc aacaccattg tggtctcctt gcagtcgaaa ctggcttcta tgtccaatga 720
cttcaaatcg gttttagaag tgaggacaga gaacctgaag cagcagagga gccggagaga 780
gcagttctcc cgggcacctg tgtcagccct gccccttgcc cctaaccacc tgggcggtgg 840
tgctgtggtt ctgggggcag agtcccatgc ctccaaggat gtcgccatcg acatgatgga 900
ctctcggacc agccagcagc tgcagctcat tgacgagcag gattcctaca tccagagtcg 960
ggcagacacc atgcagaaca ttgagtcgac aattgttgag ttgggctcca tctttcagca 1020
gttggcacac atggttaagg aacaggagga aaccattcag aggatcgacg agaacgtgct 1080
aggagcccag ctggacgttg aggccgccca ttcagagatc ctcaagtact tccagtctgt 1140
cacctccaac cggtggctca tggtcaaaat cttcctcatc ctcattgtct tcttcatcat 1200
ctttgtggtc ttccttgctt gaaccctctc tactctgagg cactctgttg gggtttggga 1260
ccctcctggg aaggcaagtg gccagtgctg ccactgagcc tgtgcagggt acttgggaga 1320
aaggccctgt ttccctggaa ctgctaagaa tgaccactgc ccctgatccc ccaccccttg 1380
cctctggcca ccctgtcctc cccccaccac cctcaggcct atgaaacaca cagggttcta 1440
gatttgaact ctgctgtgaa gtgactggaa gggagcagag gccagctggg ggccagtggg 1500
ggaggttgtt tccactagga gatttttata aaccctctcc agcctctccc aaaggaagcg 1560
ttggcagcaa agggagatga tgcccttacc caccttcctg tgagtgaaga gaggaagcag 1620
ccccagggac caattttccc aattgacctc tttcttcctc tttcaccatg tgaggcaggg 1680
agccctgagc ccttcagctg cctgcacaac ccctgacatt ggctgctggt gactcaatct 1740
gccaaatgtg ctgcagctcg ttttctccca attacagcaa gactgtcagc ctca 1794
<210> 58
<211> 4604
<212> DNA
<213> 人类
<400> 58
gggaggtggg actgactgag tcttccgtgt gtcgccgccg ttgccgcctc agcttcagcc 60
tcgttactcc tgcggttctg tgactgtgct gctggcgtta acggcgcgag gtgaagggag 120
gtgacggagt gtgcccgcgc gcgcgggggt cccctcagtc ccagcagttc ccttcgtgcg 180
cggggggcgg cgagggtctt cagcagtcgg gagaggccct tgacggcgcc atgtcggcgg 240
gcggtccatg cccagcagca gccggagggg gcccaggggg cgcctcctgc tccgtggggg 300
cccctggcgg ggtatccatg ttccggtggc tggaggtgct ggagaaggag ttcgacaaag 360
cttttgtgga tgtggatctg ctcctgggag agatcgatcc agaccaagcg gacatcactt 420
atgaggggcg acagaagatg accagcctga gctcctgctt tgcacagctt tgccacaaag 480
cccagtctgt gtctcaaatc aaccacaagc tggaggcaca gttggtggat ctgaaatctg 540
aactgacaga aacccaagca gagaaagttg ttttggagaa agaagtacat gatcagcttt 600
tacagctgca ctctattcag ctgcagcttc atgctaaaac tggtcaaagt gctgactctg 660
gtaccattaa ggcaaaattg tctggcccct ctgtggagga gctggaaaga gagcttgagg 720
caaacaaaaa agaaaaaatg aaagaagcac aacttgaagc tgaagtgaaa ttgttgagaa 780
aagagaatga agcccttcgt agacatatag ctgttctcca ggctgaagta tatggggcga 840
gactagctgc caagtacttg gataaggaac tggcaggaag ggtccaacag atacaattgc 900
taggacgaga tatgaaggga cctgctcatg ataagctttg gaaccaatta gaagctgaaa 960
tacatttgca tcgtcacaaa actgtgatcc gagcctgcag aggacgtaat gacttgaaac 1020
gaccaatgca agcaccacca ggccatgatc aagattccct aaagaaaagc caaggtgttg 1080
gtccaattag aaaagttctc ctccttaagg aagatcatga aggccttggc atttcaatta 1140
caggtgggaa agaacatggt gttccaatcc tcatctctga gatccatccg gggcaacctg 1200
ctgatagatg cggagggctg cacgttgggg atgctatttt ggcagtcaac ggagttaacc 1260
taagggacac aaagcataaa gaagctgtaa ctattctttc tcagcagaga ggagagattg 1320
aatttgaagt agtttatgtg gctcctgaag tggattctga tgatgaaaac gtagagtatg 1380
aagatgagag tggacatcgt taccgtttgt accttgatga gttagaagga ggtggtaacc 1440
ctggtgctag ttgcaaagac acaagtgggg aaatcaaagt attacaagga tttaataaga 1500
aggcagtaac tgacacacat gaaaatggag acctgggcac tgcaagtgaa actccgctag 1560
atgacggtgc ttcaaaatta gatgatctgc acactctgta tcataaaaaa tcttattaaa 1620
ttgaccatat ctccagacaa gattgttaat cagactattc tgaatttggg gcactgggga 1680
agatggtgac aaagactaca aaatcagggg aggctgtttg ttgcctaaat gaaaggcggg 1740
tacctcaggg cttcatgtga acaattctca atgcataaaa caccctgttt tctgtggtag 1800
accataatta gctattgcat gtaaagcaat tttgattttc ttgaacttgt aagcaccaaa 1860
gcatgtgttt cccaaagggg tattactggg ctcttaagta ccaaatgaaa ccctactgtt 1920
ttacttggtt ccttttccct ttagtaggag gacagtgcta actggaattt tataaggagt 1980
accctttaaa atacagagag taagtgaatt catattttat attctagaat gttaactgtg 2040
gtatttcaga agacagagct tgactcaatg aattgtagaa atataggctt gacttaattt 2100
ttgtaactga aaggctttag acttaaaaaa atttattgtg catcctaaaa tctaaaccaa 2160
ttattaatga tcatttattg taatgagttt gcatttcagc tttattcaat gcagtacaaa 2220
atagttttct ttaagcagtc ttttatcaat caatgctgca ctagaaatag attctcaaaa 2280
gttactaaac attttacttt ttttgttttt taaaagaaat gcagatgagt gtaaaacatc 2340
tgttctcaat tatgttgatc tgtgtgcgca gtactggagc atttacccat tcatgttgag 2400
cctcaaatgc ttgttttctg gggtccacaa aagacagttt tatacatttt gagttgttca 2460
taaagtttgt cttgtgatag tcctggcact taaagacaaa tttttctggt agtaaaagtt 2520
cagatttatt actatgtcat gaaacacagt acattcaaat caaacggcag ttttctttct 2580
aagtaaatga tttccagtca tctaaaaggt gggcaagatg agataaagac attttgatac 2640
agtaattgtt ttggttgggt tttcatgtca gtttatgttt gactaaagct ctcttcatat 2700
gcaggtttat aaatttgtta ggtctgttgt cccatgatta aacatggagt gcctcctctc 2760
tgatttaata ttctgcaggt cattgtaacc tgctaggcaa agtcacaaca ttgcattaaa 2820
gaggtgatag ctttgctaat atcactgttt taaaggacgt acagttaaag gaatattaag 2880
tgggagaaag cctacaaggc ttttagaata ttatcagtat cttcatttct ggtattcaga 2940
tgttatgtga taaaacacat tttttttggc tttcccagat acactatata tttgttcaag 3000
ggtaaatcta taaaatgtat atactttatt ttgtggtttt gctatttata aatttaatgt 3060
tttaactgtt gctcatttat ggtttgtttt gggtggtggt gttcatctgt atatcaccat 3120
gttaatttgt aatggaagtg cacttcgtag tgtatattgt tactgacatt aaaatacttt 3180
atagcattgt ctctgagcaa aagctagtat ttaattgtac aaatgaataa gcaagttaca 3240
tgttattgtt tgctcttgac agggtaggcc tcttaaaaga aaaaaaacaa cttgtttttt 3300
ctttatgaat cccctatgcc aaacacatac cttccatgca tgacatgaga tctgcaaact 3360
ggattttagc caccgtattt atttagtcaa aaaaattgtc cattgtagca gacccgaaaa 3420
cctttttgct gtgacatgaa accatgttat tcttatcttc ttaaaacaca gcctgggatg 3480
gaatggccat ggcatttttt tcagagaaca tcctttatct gctatgactg aatccttagg 3540
aaatgtaagc tataaccctt tgattttcaa gaactaccga ataagtgtat gaagaggtgg 3600
ttttttaaaa cttcaagttg gaatttttat gaggtcactg tgtaatttga agaattgtgt 3660
gagattgtca tgatataaat tccttttaag gactgataaa tagaatgaaa agtttccagg 3720
tagtttaaaa ctccacaggt cagtttcctt ttcattcctg cttcactgtg gtttataagc 3780
ctacgggaga gcaccgttgc tcagatgcta ctgtgagctt cctgtccggt gttagaaagt 3840
aactagttaa aagttcattt tagaatgtat ggtttttggg gatgaactaa gaattagtta 3900
ttagttccaa aggactgaga accaatttta atattttcac atttatagga aagaaattca 3960
tatgtccctg aaacttctag gacaaaacca aacaagtaag gagggaactg ttgcaaagcc 4020
atttcatcga gaaggggaca gaaggagaaa tacacacatg tatacacaaa cagaatggtt 4080
gagaaaacgt tttaataaaa tgtgagggtt gtatgtgtgc gtgtatatat ttacacttaa 4140
cctctaaaat tctcttctac agtatctctg ttatgaatat gatggaaaag caacattttg 4200
gtggtgagac tattgttaaa ataaatttga gaaagacgaa aattttgtga gtcttgataa 4260
ttacaagtca acagctatcg aaagttagca cagcttgtct gtggtgctgt ttttttcccc 4320
actgcagtgg acttatgctg ttttcatgtt tagaaacaaa aaggtttcat gtgattcatg 4380
tgtaagatgc acagtatttg acatcctgat tatgtaatcc ctattccatc tatccagtct 4440
tacacttatg gttggcctca aatctattgc atttatgata atgtattata tctagttgag 4500
tttaatattt ttttattagc ctgtaaataa agatggcatc ttctacatta aaatgatatt 4560
gatctcattt ttttaaataa acattttgtt tccttgacgt taaa 4604
<210> 59
<211> 3319
<212> DNA
<213> 人类
<400> 59
aaccggaagg ggggctgtga ggacgtgttc cgaggaagcc agagccggag ccgtggcctg 60
cggggccggc gacatggatc ccctgttcca gcaaacgcac aagcaggtcc acgagatcca 120
gtcttgcatg ggacgcctgg agacggcaga caagcagtct gtgcacatag tagaaaacga 180
aatccaagca agcatagacc agatattcag ccgtctagaa cgtctggaga ttttgtccag 240
caaggagccc cctaacaaaa ggcaaaatgc cagacttcgg gttgaccagt taaagtatga 300
tgtccagcac ctgcagactg cgctcagaaa cttccagcat cggcgccatg caagggagca 360
gcaggagaga cagcgagaag agcttctgtc tcgaaccttc accactaacg actctgacac 420
caccatacca atggacgaat cactgcagtt taactcctcc ctccagaaag ttcacaacgg 480
catggatgac ctcattttag atgggcacaa tattttagat ggactgagga cccagagact 540
gaccttgaag gggactcaga agaagatcct tgacattgcc aacatgctgg gcttgtccaa 600
cacagtgatg cggctcatcg agaagcgggc tttccaggac aagtacttta tgataggtgg 660
gatgctgctg acctgtgtgg tcatgttcct cgtggtgcag tacctgacat gagccagcca 720
cgctcagtgg ctgaacagca ttcccacagc ctgcaagtgt gtgtgtgtgt gaaagagaga 780
ggggggccca gaggccgcct tttgaaatgt ttgcctgtct gaactgtgaa gacacttggg 840
agtgattgtg gtctaatttc caacctgctc tgttttctgt gacatcttgg agggggagct 900
agtgccacca ccatgcgcgg tgcttaggaa atgaaagaag tcccgggtct gtctctctca 960
ctctcgctct cactggggga gggaaagaat ggctttggtg gctttgttca catagctgat 1020
gcgtgccctg ggaaggtgtc cacagtgagc cctgtgtgca ggactgtcca cacggttcac 1080
accttgtcac catcaggcct ttctggctcc tgatagggtg gagcaaaagt ggaaaggaaa 1140
ggaaagaggc cttttctcac agccattata ttaaatagta ggtcgattca catcctcgtg 1200
ctcctggcca ccctcccctg tgcctcagtg acatgtagat gactgactgc caatacttgt 1260
caccattccc tggaagcagc tacctagggg aaacaagatg tagtgctatt gccgataaca 1320
agtaagattt tccacactac agctgggtgt ttctcttttc taaagtgagg ccagtgttat 1380
ttcccgggag tgttcagtct tgaccctagt cactgatttt ttctagttgt taatagagtg 1440
gttggctttt aaggttcaga gactgtggct tggcacctgc gcccaggctt tgtgggcctt 1500
tgccccttag aaagtagctg taggcaaaga tttgtgattt tccaattaca gtctcagctc 1560
tagttttagt atctctaatt ctttggttcc cttctcttcc ctgaaatata ttagcacctg 1620
ccagccaggc cctcattttg cccagccagt gtgggcagat cccaccgtgg agacatctgt 1680
agtgtgtatg tccttgtaac actctgtttt cagggactac aacctttttc cttctgtgac 1740
cagccccgga ttcaggctgt actaatacca ggtatattgt ggaatttagt ataaaggcca 1800
atctgtcctg aagtccatct aatgtggtga atcactgaaa gtctcagaaa gacctggtta 1860
gtgtatgttc tcatttacca caggcctacc agccctgggc acagcagctt catggcaaga 1920
cataaaatga cactcaaaat ccttcagatc tggaaaccgg ctcagtatta accctacctt 1980
tggttgtcct gccctacctg ctctgttagt ttcttgttgc ttgaactgtc ttctgtctta 2040
tttcccttcc tttctgtgtt cctcttcacc tctcttgttc ccctccccgc tgctctgtag 2100
tcatgttggt cctttcaggc acctctgtgg catagctccc ctttggtaag ttttcttaat 2160
tgtcatagat taactgagtt tcctggatgc taatttcaca ctttcggttg gaggagatct 2220
ccattgttcc tacccctccg ggccaaatgg gccccaggtt tccaaggaag gagcaatctg 2280
tgactcctaa aatgggttgg ggccctgcca gagttaaagc agtgactgga gggtggactg 2340
gggggttgca gcatctttag acctagatct gtctaactct ggggaggcac attgacattt 2400
ccattacaca cagcactgct gcggtgccag ggacctagcg caggactttt ggtaatccat 2460
aaaatggatt ctgagactgc gacggcaagg ctgtcctgtc ccccaggcac ccaaggatcc 2520
tgccagacag cacactttgg aggaaggtct gcagggagca gctgagccat ttgttcttga 2580
actctgggag gcagaagtcc ccgcacccat catgcgtgga ctgataggac atcttttcgt 2640
ggtgtgcacc agtgctttcc acacttgaca gtggttggct ttgatgaacc ctcatgctgc 2700
accttcagag ccagtcctct agtttggaat aaaaattgca gaggtggttt ttgggtcttt 2760
accacctgcg gctggtggac agcagccagt gtgtctggac acccaggggc attgagactg 2820
catgttgtca catgaccact tctcttcaca catctgcttt cagtgcctgg tgaaaaatag 2880
accttggcct aacagtgtga ctctctccac cgcctcagtg tagggaaggg tccaggccag 2940
ggaaggagca ccctctagtg gaggcggggg tgaattctta ggtcgagctg atgcaagaaa 3000
ctccggtagc cagcctctgt gaccttgtac atgagtttgg tgtgcctatt gtgatttaaa 3060
acaggtgggt tatcaagagg aacttgagat ctctttatta catggacatt tacttcaggg 3120
ggaccactgt aagaaaagcc aaactccaag accaagtaag ttagaggagt cttgattttt 3180
tagacttcac tgcggagttc tgtacaccct ttgccctgat gaatttgaat gggtttgatt 3240
tgcaaatttg gatttacacc cattgttttg gaagcacatc agctgaataa agttgaggtt 3300
tattttattt agaaaatca 3319
<210> 60
<211> 1469
<212> DNA
<213> 人类
<400> 60
aaccggaagg ggggctgtga ggacgtgttc cgaggaagcc agagccggag ccgtggcctg 60
cggggccggc gacatggatc ccctgttcca gcaaacgcac aagcaggtcc acgagatcca 120
gtcttgcatg ggacgcctgg agacggcaga caagcagtct gtgcacatag tagaaaacga 180
aatccaagca agcatagacc agatattcag ccgtctagaa cgtctggaga ttttgtccag 240
caaggagccc cctaacaaaa ggcaaaatgc cagacttcgg gttgaccagt taaagtatga 300
tgtccagcac ctgcagactg cgctcagaaa cttccagcat cggcgccatg caagggagca 360
gcaggagaga cagcgagaag agcttctgtc tcgaaccttc accactaacg actctgacac 420
caccatacca atggacgaat cactgcagtt taactcctcc ctccagaaag ttcacaacgg 480
catggatgac ctcattttag atgggcacaa tattttagat ggactgagga cccagagact 540
gaccttgaag gggactcaga agaagatcct tgacattgcc aacatgctgg gcttgtccaa 600
cacagtgatg cggctcatcg agaagcgggc tttccaggac aagtacttta tgataggcac 660
ccaaggatcc tgccagacag cacactttgg aggaaggtct gcagggagca gctgagccat 720
ttgttcttga actctgggag gcagaagtcc ccgcacccat catgcgtgga ctgataggac 780
atcttttcgt ggtgtgcacc agtgctttcc acacttgaca gtggttggct ttgatgaacc 840
ctcatgctgc accttcagag ccagtcctct agtttggaat aaaaattgca gaggtggttt 900
ttgggtcttt accacctgcg gctggtggac agcagccagt gtgtctggac acccaggggc 960
attgagactg catgttgtca catgaccact tctcttcaca catctgcttt cagtgcctgg 1020
tgaaaaatag accttggcct aacagtgtga ctctctccac cgcctcagtg tagggaaggg 1080
tccaggccag ggaaggagca ccctctagtg gaggcggggg tgaattctta ggtcgagctg 1140
atgcaagaaa ctccggtagc cagcctctgt gaccttgtac atgagtttgg tgtgcctatt 1200
gtgatttaaa acaggtgggt tatcaagagg aacttgagat ctctttatta catggacatt 1260
tacttcaggg ggaccactgt aagaaaagcc aaactccaag accaagtaag ttagaggagt 1320
cttgattttt tagacttcac tgcggagttc tgtacaccct ttgccctgat gaatttgaat 1380
gggtttgatt tgcaaatttg gatttacacc cattgttttg gaagcacatc agctgaataa 1440
agttgaggtt tattttattt agaaaatca 1469
<210> 61
<211> 4540
<212> DNA
<213> 人类
<400> 61
gggactggag gctgccgagg gggccggcgc ccgagtccgg gattcggcca gtggtgctga 60
gcgagtgctg gaccagcggc cgtcctgtgc acctggcctg tgcgcgtgcc cgctgctcgg 120
cttcacccag actaaggcgc gggcagctgc gggaacaggc ggggtgggcg gagggagacc 180
gggaggcacg ggcgccctgt gcgcggagga ggtgaaggcg gccggggccg ggacgccatg 240
tccatggagg accccttctt tgtggtgaaa ggagaggtac agaaagcagt caacactgcc 300
cagggattgt ttcagagatg gacagagctc ctccaggacc cctccacagc aacaagggaa 360
gaaatcgact ggaccaccaa cgagctgaga aataacctcc ggagcataga gtgggatcta 420
gaggaccttg atgaaaccat cagcatagtt gaagcaaatc ctagaaaatt taaccttgat 480
gcaactgaat tgagtataag aaaagccttc attacaagta ctcggcaagt tgtcagggac 540
atgaaagatc agatgtcaac ttcatctgtg caggcattag ctgaaagaaa aaatagacag 600
gcactgctgg gagacagtgg cagccagaac tggagcactg gaacaacaga taaatatggg 660
cgtctggacc gagagctcca gagagccaat tctcatttca ttgaggagca gcaggcacag 720
cagcagttga tcgtggaaca gcaggatgag cagttggagc tggtctctgg cagcatcggg 780
gtgctgaaga acatgtccca gcgcatcgga ggggagctgg aggaacaggc agttatgttg 840
gaagatttct ctcacgaatt ggagagcact cagtcccggc tggacaatgt gatgaagaaa 900
cttgcaaaag tatctcatat gaccagtgat cggcgccaat ggtgtgccat agccatcctc 960
tttgcagtcc tgttggttgt gctcatcctc ttcttagtgc tgtgacggcg gggcctctgg 1020
gtgcgagttc ctcctgcata tgaaccgagg ggaggaggag aagctgagca cgtgtgacat 1080
tgccgtctac tcacattcct atcctggaaa catactgctg cactgacttt tctccgtgtg 1140
accccacaat tgacatggct cctccatccc agcgctggaa gggccagtgg gaagaggaaa 1200
tagatgtctg cactcctggc tgcagctgga caacagaagc cccatgccgc ctgtccagtt 1260
cggaggagaa ctagctgctg ccttgccttc cgggacctcg tttgctgagg agggacttac 1320
agactccact ggtgttttgc tgttgctcat tccatgcatc tttggcagct cttttcttct 1380
gctcagaccc ttccccgtgc tcagacagtg caccgctgtc ccatctaaag aaacctgtca 1440
ggaatacgag cttctgggta tgtttcgttt cccattgctg tagcatttct tatcccctga 1500
gagctgatga ttattgagga cagaaggctc agaaacagtt tgtgacagaa aatgcagtgt 1560
ttcatttttc agggataaat gctaagataa aattgctttt ccaggtcatt tttttttgtg 1620
gtaagaataa ctaatggaaa ataatgaaac accctggggt ttgggggtgc taacaacttg 1680
tggctttaac tgacaggagc aattaaaaag agcaagaggg ttctgcattg gcatagctta 1740
gggaagggtt aatgatgtcg ccacaggtca gctcctgatc cttgccgact tgatgttgct 1800
gtaccagggc ttcctcccca gaggtgcagc ttgcgttttg agggtgattg ctacatatgt 1860
tgttgctaaa cagctcagta acacacttga atgaatttgg ataccagatt gtcctcatta 1920
cagttctttt actcttaggg cactctacac tgggggttgg ggttgggagt ggttagtaca 1980
tttattacat ttattaagaa acgtaatgac ataaaaggtt agctctgggc cagacttctc 2040
ttactctgtg ggtaatggca aggatgtgta ggtaaacttg gttctttttt ttccctaaga 2100
tgacagcttg attttatcat ctgcagtcaa ataactgagc caatccaaat ttaaatgata 2160
gatgctttaa ttgagtttaa gtagctgaaa ctgctgagac actaaacttt aaccttctga 2220
tgacttttta aaatgcctca aatgtgcaca tgtatatagg atatttttat aacttccctg 2280
atgaataatc tgatattaaa gtagtatttg gacccagagc cagaactcgg tggtggaggc 2340
tgctggtctc tcctcaccac cttcttttgc acttggaaag aacagcaaca tctggataga 2400
gttctggctt tgacttctca tttccttgtc tttttgggtg cattcctcag cacacttttt 2460
ttttaaacct ttttgttttg ttttgtttgt atttcatgtg gttttatttg ggggttttgg 2520
ttttttcacc cttttttgtg atttgcaatg atgtgcttgc ccagctaact tttgaattgc 2580
actttttaat aaatattctt aacaattttt gaagaaggat attttatctc atttgagatc 2640
atggtaggtt aagaaaatat gcctgttgat gaaagctaaa agcaaattta tgaaactaaa 2700
agggtgattg acatccatgt ttacactccg ctctaatgtt tgatatataa ataagttatt 2760
ttcaaattag gaaaaaacag tgagtattac aaagggcttc agatgtttag agtactaggt 2820
tatttatgtt ttacaaagtt tgaatcttct ataaactaag aaaggggatg atccttagat 2880
ttgcattaaa atatagaagt cttttaaagt aaatgtgaac cttgtctaag tactgtaatc 2940
cacacaacac attataagaa gcaaaccagc atcttaagga attataaaat taccctattt 3000
aaaagccatg ctattgttct gctattacca gatttattgt gccacacaaa aggatcatgt 3060
gtgtcagcag gggccgtttg gaacaaacct agtcattaat gagtaagata ctcctgttag 3120
ttcagggacc aagttttatg acccagaggc ttaatgatgt ttggatatat ttcaaatcgg 3180
cgtgcttacc tcactgattt aaattatttt ctaaatagtg gccattgtag acctgactca 3240
ggctgaagct aaatagagaa caatttagaa agttaactaa caatacagtg cattctaccc 3300
gtagggccac catgcccttc tgcccctggc tgatttgatc ctgtgtctga tcccattgca 3360
ccctgactgg gcagtcccta cagaaccagt gttaatttga agggcctcca ctcaggctcc 3420
aaatgtggca gccaaagaga acaatccagg gaacctacat ttatttttaa ggacaaatat 3480
ttcctcctca gtggtcctaa tgttcagggc tttagaggga acccaggtgg tctcttcacc 3540
ctgtgtccta gaatgggaga gtaagtagac agtggtgata accccacact gcttataagt 3600
gcatctttat agtatttggg gctttcctac ccctttagcc ttctgtacct agtaccatat 3660
tccagtttta aagaactggc agaatgtgat ggataacaga ggaagagctc aatttatgtt 3720
tattggaaga acattttact taaatgattt gaggggtggg agggagtgaa ctactgagtt 3780
tgccagagtg aaaatccatc tgaaaaactc agctaccttt agtttttagt cctcattttt 3840
ggtcttgtct ctgcggactg tgaagaatca caatgctcta tatgccctgg actgtgtggc 3900
aaatgcaggt tgcagcgtgt gtgttacatg aggatcttcc acaatttcag aatgcacgcc 3960
agagctgaag ggggaaactt ggtaacttgc ccattattct ctgcttttag ccagagttaa 4020
acagactgat gggtctggta gccaacaact tggcaacttc cactccttct cacctcgtga 4080
gattaagggc tgtgaaaaga aatctagtct aactccaaca gaaatctgtc tctgttaagt 4140
gttttacctt ctgtaagtag agatggtaga gccaagattt ttcttttggt aatttccctg 4200
tctataaagt gagaccaaag ggatatctgt tccctgttac ctttttggag aattcataac 4260
atttgaagat caaaaaattg aatgataaat atgaatggct tttcaattct gtggactttg 4320
taccatttgg cttcaccttg tactgcaaga tgaatttgta aacaaaacaa aattggactg 4380
tctggaaagc taaagttctg aaatatggaa tgtactgcct ctaatttttc tttgtcttcc 4440
tctcactggc atttttttct ctcccaggtt tcttaagaat aatgtttttt aaaggaggct 4500
ttttgcccat caagaataaa aagaaataaa accaaaaaaa 4540
<210> 62
<211> 5220
<212> DNA
<213> 人类
<400> 62
atcccggctg acgttggacg acaaagatgg cggcagggac cagcagttac tgggaagatc 60
tcaggaaaca ggctcgacag ctggaaaatg aacttgacct gaaactagtt tccttcagca 120
aactatgtac aagttacagt catagcagta cccgagatgg aagacgcgac aggtatagtt 180
ctgatacaac acccctttta aatggatcaa gccaagacag aatgtttgag acaatggcga 240
ttgagattga acaacttttg gcaaggctta caggggtaaa tgataaaatg gcagaatata 300
ccaacagtgc aggtgtcccc tccttgaatg cagccctgat gcatacatta cagcggcata 360
gagacatatt gcaggattat acacatgaat tccataaaac caaagcaaac tttatggcaa 420
tacgggaaag ggagaatctt atgggatcag tacgaaaaga tattgagtca tataaaagtg 480
ggtctggagt aaacaacaga agaactgagc tatttttgaa agaacatgac caccttcgaa 540
actcagatcg tctgatagaa gagacaataa gcattgctat ggcaacaaaa gaaaatatga 600
cttcacagag aggaatgttg aagtcaattc acagcaaaat gaacactttg gccaatcgtt 660
ttcctgctgt aaacagcctg atccagagga tcaacctgag gaagcggcgg gactcgctca 720
tcctaggggg tgttattggg atctgtacca tcctgttgct gctgtatgcg ttccattgat 780
gggacatctt cagggactct tgacagccac cgctttcaca ccctggtctg gaataaggaa 840
acatcggagg gagaagttga ctgtcttgat aattagcctg accagcagga tgaatgcaag 900
actgacagtg atggactctg tgacatggtc aggttgagct gaagccacag tttctctgtg 960
ctgtgttttc taacacattt ttctgttttt aattaaaaaa aaaaaaaaaa ggttttcagt 1020
tgcttttgtc tccctaggag gcaggtaaac caatcaaaaa cagagttttc tgtgtttcca 1080
tgatagtgtt gaagcctaat gacaagccag gtcttacagc tgggctcttc agaaaaccag 1140
gtttctacat ccaaagactg cttttctttt agctgccaga ttggattgtg aataaaaata 1200
attcttccct ctccctctcc ctctccccac ggtctccctc tttccacggt ctccctctga 1260
tgccgagccg aagctggact gtactgctgc catctcggct cactgcaacc tccctgcctg 1320
attctcctgc ctcagcctgc cgagtgcctg caattgcagg cgagcgccgc cacgcctgac 1380
tgcctcggcc tcccgaggtg ccgggattgc agacggagtc tcgttcactc agtgctcaat 1440
ggtgcccagg ctggagtgca gtggcgtgat ctcggctcac tacaacctcc acctcccagc 1500
cacctgcctt ggcctcccaa agtgccgaga ttgcagcctc tgcccggccg ccaccccgtc 1560
tggaaagtga ggagcgcctc tgcccggccg ccatcccatc taggaagtga ggagcgcctc 1620
ttcccagccg ccatcccatc taggaagtga ggagcgtctc tgcccggccg cccatcgtct 1680
gagatgtggg gagcgcctct gccccgccgc cccgtctggg atgtgaggag ctcctctgcc 1740
cggccgcgac cccgtctggg aggtgaggag cgtctctgtc tggccacccc gtctgagaag 1800
tgaggagacc tccgcccggc agccgccctg tctgagaagt gaggagcccc tccgcccggc 1860
agccacccca tctgggaagt gaggagcgtc tacgcccggg cagctgcccc gtccgggagg 1920
gaggtggggg ggtcagcccc ccgcccggcc agccgccccg tccgggaggg aggtgggggg 1980
gatcagcccc ccgcccggcc agccgccccg tccgggaggg aggtgggggg cgcctctgcc 2040
cggccgcccc tgcccggccg cccctactgg gaagtgagga gcccctctgc ctggccacca 2100
ccccatctgg gaggtgtgcc cagcagctca ttgagaacgg gccatgatga caatggcggt 2160
tttgtggaat agaaaaggcg gaaaggtggg gaaaagattg agaaattgga tggttgccgt 2220
gtctgtgtag aaagaagtag acatgggaga cttttcattt tgttctgtac taagaaaaat 2280
tcttctgcct tgggatcctg ttgatctatg accttacccc caacctggtg ctctctgaaa 2340
catgtgctgt gtccactcag ggttaaatgg attaagggtg gtgcaagatg tgctttgtta 2400
aacagatgct tgaaggcagc atgctcctta agagtcatca ccactcccta atctcaagta 2460
cccagggaca caaacactgc ggaaggcggc agggtcctct gcctaggaaa accagagacc 2520
tttgttcact tgttgatctg ctgaccttcc ctccactatt gtcctatgac cctgccaaat 2580
ccccctctgc gagaaacacc caagaatgat caattaaaaa aaaaataata taataataat 2640
tcttgtcctc ttattttaca ctcataatga gaaatcacaa gttctttctt gatgatctgt 2700
gctatagatt tctactctgt ctcctcaact ctgttgatat ttggggaaaa ttctgttttt 2760
catagattct ttgagatgct gatggaccag cttcagcatg tttgaggttg tctgaaatgg 2820
agatcactgt aaaactgtct ttttctttta aattacaagt acactggggt taactgtatt 2880
gctggaaaaa catcaagaat gacagtctta tatttaaggc accagtcatt gtttccattt 2940
tttttttaat tcttcccttg gattaatatt ttctactgaa aagaaatgaa atctcagttc 3000
cactatgata aaagaaacga atcaccagtg tctgtcagtg cccccactgc tcctcctcat 3060
accagcattg acactggtag ctgaggaagg ggactgctca atttctaatg tgatctattc 3120
aagaagccac atataaaaag gcattgaggg ctcactgtcc agagaattgc ttttgtaaat 3180
gctccacaac gtatgggcaa aagtttaagg actactgcct gatgtaccag gaatcctgag 3240
ttctgtgaaa atctgttcat tccaaatctg ttaagcattt ccaaacatcc agagaatggt 3300
ttcactgttg agggtgcatg tggcagaatc tgtctctctc tgcacctgtc ttctgttacc 3360
atccctggac agtgacagat tttaagccag ccaccagaat tcttttcgag ttaaccattt 3420
cttagtttct gtaaattcat gacttgtctt actgaactac agcctggttt gtagacttcc 3480
aacatctaca ctgctgctct tcaccattgg aattcactgt ggtatttata gtattggctt 3540
cagtccgagc cacaggcaat aaaaggatat cagctgtagt tctcagctac atcatggtgt 3600
atagatgctg ttattcaggc gaacttgctc atgggtggac taacacctgg tttggtacag 3660
agactgagaa gtttttcatt ctggtgtcaa agttttgtta cattatgggt gtgaagggca 3720
tttgatatat ttttcttaac tatggggttt atttttctaa atgtgggttg attgactgtt 3780
aattgattca gggtaccctt aaaagaaaag aagttttccc attgtgaacc ttaaatgatc 3840
agagaagtaa gttcattgat taaattctct gttgggagaa caaaactttt ctcccttgac 3900
actttattat ctttgatttt tcaaagggcc ttgattggtg gttgtgtctc ggttaaaatt 3960
tatgggactt tgctatgtag ttggcattta taaaatctga agtatcataa ataaagttat 4020
ttatttaatt atactaccag tcttttttac tggtctgatt cttttgtgca ttcattaaag 4080
ctgattgtgt gagagtgaac tgggacacaa gctagtctag ctcactgcag ccaagcaaac 4140
cctgttgatg gctgatgggc ctttccatta gggttttgct tatgtgaagt aatggaatta 4200
tgttggttat tttctttatg aaaataaacc agttcttcca aggaagttaa aaggcttggt 4260
atggatgttg gtgtcagata ggtctgacta acctctccgt gctgcagcct atactaaggt 4320
gacccagggc cacatgtaga cagctaggcc agtgcttttt cctcttaggg tttctttgca 4380
gaaagaaacc tccagcaagg gaagagaggt gtgtgtccac aggaaggggc tccgtgggga 4440
tcccatgaag ggatttgagc tctttcagct ccatgtcatt taactttttt gtttaaccac 4500
cttggctttc tctccttttt tgctgtcctc cttacggacc agttaccaga ttcagaggct 4560
aacagttagt tacttgttaa tgctagtcac agccaggagg tcagaaggaa ttttctactt 4620
ctggatccaa atgttacctc ttaggggaag ttatgccccc tcaactattg tcttattata 4680
atgaatcttt cctttttggt ccttttaagt aaccactcaa aacttttcat ttcactgaaa 4740
aaatatgaaa aaccatgaca atagggctgg gtgcagtggc tcacgcctgt aatcttagca 4800
ctttgggaga ccaaggcagg cggatcgttt gaggccagga gtttgagacc agcctgggca 4860
atgtagcaag actctgtctc tgcaaaaaaa attaaaagat acctgagagc tcactttaat 4920
atcaaggtat ttgcatccat tcccaccctg ttagctctta agggaggagg gaaatcaatt 4980
ccaaccatac tttcctgtga tggaagatgt ttcctcttga aaaaatgcca atacagattt 5040
ttaaaaccta ttgttttcca aatgcacttt gtaagttttt gcttttaaaa tagcttcttg 5100
gaaccaattt tattgtattt gtacttaatt tttgttctca tctaaatgtg cattttctga 5160
ctgtatagaa gaagctttgg tatgtaattt aataataaat tagaaatcta aatgaaaaaa 5220
<210> 63
<211> 1160
<212> DNA
<213> 人类
<400> 63
gtgtgaagta agcaatctat tttcacttgc tattaacagc aaacgtacaa ctttatctct 60
tatttgactt cattatttgg ctttcaaatt aacaacatga aaactataca gaaattagtc 120
tgtgccctat aagacagaga tttagataat ttgttcaaaa catgagatga tattcagata 180
ttctctcaaa ggcaggactc caacaccgca ggtggaaaac caacaaaagg aagaaaacag 240
aaaggaggaa agggaagatg aaagaccgac ttcaagaact aaagcagaga acaaaggaaa 300
ttgaactctc tagagacagt catgtatcaa ctacagaaac agaggaacaa ggggtgtttc 360
tacagcaagc tgttatttat gaaagagagc ctgtagctga gagacaccta catgaaatcc 420
aaaaactaca ggaaagtatt aacaatttgg cagataatgt tcaaaaattt gggcagcaac 480
agaaaagtct ggtggcttca atgagaaggt ttagtctact taagagagag tctaccatta 540
caaaggagat aaaaattcag gcagaataca tcaacagaag tttgaatgat ttagttaaag 600
aagttaaaaa gtcagaggtt gaaaatggtc catcttcagt ggtcacaagg atacttaaat 660
ctcagcatgc tgcaatgttc cgccattttc agcaaatcat gtttatatac aatgacacaa 720
tagcagcaaa gcaagagaag tgcaagacat ttattttacg tcagcttgaa gttgctggaa 780
aagagatgtc tgaagaagat gtaaatgata tgcttcatca aggaaaatgg gaagttttta 840
atgaaagctt acttacagaa atcaatatca ctaaagcaca actttcagag attgaacaga 900
gacacaagga acttgttaat ttggagaacc aaataaagga tttaagggat cttttcattc 960
agatatctct tttagtagag gaacaaggag agagcatcaa taatattgaa atgacagtga 1020
atagtacaaa agagtatgtt aacaatacta aagagaaatt tggactagct gtaaaataca 1080
aaaaaagaaa tccttgcaga gtactgtgtt gttggtgctg tccatgctgt agctcaaaat 1140
aaagaagcta ttttaaaaaa 1160
<210> 64
<211> 4890
<212> DNA
<213> 人类
<400> 64
gagctgcagt cagatccggg gatggaggga gccggagaag aggagtgaga aggccgggga 60
ggcaggccct gctgtcttcc tgcaggccgg cagcctgctg gcagtggagg accaggccgt 120
ccaggaaagg aaggggtcag gaggtcgggc agggcctcag caggttcaga caagtcccca 180
gaagggagct gcaggcgccc tcgagtccag gccccaagcc tggctccggt tgtccaaaga 240
gggcctaggc caggcctctg gtgcggaaac tgagtcacag ccagacctca gggcacggcc 300
tagacgctta cgagccaaag ttaggggtag agagcagaga cctccggggg gtctcaggga 360
gtagggggct tcagggcctc ccagtctaga gccggattgg cgagttagac gcttgtagat 420
ccaaggttgg attggggtgg ggtctctggg acgttggatc gctacgcaag gattgggggg 480
attcaagtgc ttagagatcg aagtctgccc tgggtagggg gagtcagaca attggaaagc 540
ctaggtagtt atttggggag gggtctctac gccttggcga agcgcacagc tgcatctttt 600
tggcttgagg cctgaggcct tgtcgagaag cttccgtgaa agggtgggcc agccgggcca 660
cgagaaagaa agtgaataaa tcaggaatat aagtgggcgg ggggcccctg agaggggggt 720
cgcaaagggt gagacatggc caccaggcgt ttaaccgacg ctttcttgtt gttgcggaat 780
aattccatcc aaaaccggca gctgttagcc gagcaacttg ctgatgaccg tatggcactg 840
gtgtcaggca tcagcttaga tccagaagca gcgattggtg tgacaaaacg gccacctcct 900
aagtgggtgg atggagtgga tgaaattcag tatgatgttg gccggattaa gcagaagatg 960
aaagaattgg ccagccttca tgacaagcat ttaaacagac ccaccctgga tgacagcagc 1020
gaagaggaac atgccattga gataactacc caagagatca ctcagctctt ccacaggtgc 1080
cagcgtgccg tgcaggccct gccgagccgg gcccgggcct gctccgagca ggaggggcgg 1140
ctgcttggga acgtggtggc ctcgctggcg caggccctgc aggaactctc caccagcttc 1200
cggcacgcac agtcaggcta cctcaaacgc atgaagaatc gagaggaaag atcccagcat 1260
tttttcgaca catcagtacc actaatggat gatggagacg ataacactct ttaccatcgg 1320
ggttttacag aggaccagtt agttctggtg gagcagaaca cactgatggt ggaagagcgg 1380
gaacgagaga ttcgccagat tgtacagtcc atttctgacc tgaatgaaat attcagggac 1440
ttaggggcga tgattgtaga acagggtaca gtccttgaca gaattgacta taacgttgaa 1500
cagtcctgta tcaaaactga agatggtttg aaacagcttc acaaggcaga acagtatcaa 1560
aagaagaatc ggaagatgct tgtgatttta atattatttg tcatcatcat tgtgctcatt 1620
gttgtcctcg ttggcgtgaa gtctcgataa gtggcattgg gttttcgtgt gtgccgcgcg 1680
tgtggatctc ccgggtgtga ggggcttggc ctgcgccccg ccagctgccc gcagaggtgc 1740
agcctcgagg aatctgaggg cgtcggggca gcgaaccttt gcatccacgg actcctcctt 1800
ccctagtcct gctcaagcgg tccggggaat gggtttttgt ttttccttca ttgttgagaa 1860
tttaaggacc tttgatactg ctgcacaata gagattgagt tctgggatca gttataatat 1920
atattttttt tagaaagaga aaatgagctg agagtttaca ggcactgcag aagctgttca 1980
gtattatatg tgtatatgct atttttttag cagccatgtc tgagcagaat gttaacataa 2040
tttttggaaa aattttcttt aaaccatctg gtttttaaga aatttggtac caaaaattga 2100
tgagtagagg caaaaatgcc ccttcatctt tctctatata ttttccagtt gaaaacaaac 2160
taagaagtcc tttaagaatt tataatccgt tccccattaa cttaatttag cttttccatc 2220
actgttaatg atcagagtaa caaagtgtga aaaataagaa accatcattg atgttaatta 2280
acacatttag atgggccagt taaaacagct tcataagttt taaattaatt gtaaatggaa 2340
tattcctcat ttaaaatttt tgcactgcat tttctactgt aaaccaaaag aggttactaa 2400
gcaaaaccac ctaaatttaa gttggtgatt taaatgaatc tcacattaaa agaaagcttg 2460
acagtgttat gaaagccacc agactcagcc agtgtgtccc catgggtatc cccagccatc 2520
cttgctcaat ccattactta tatactaact acataatgac ctgttcaaac cagactctat 2580
ttaatgaact gtgaatttac acagaggcca ttttaaatgg gtcaccccat ttaggattag 2640
tggatctcaa attattaacc aaacatcact ccatttcaaa gtaaaatatt ccaccagcga 2700
tttgatttat tggctcttcc attgccactg agcaatgccc aggaagcagg cacattgcca 2760
aggactgggg gcatcttgac taggaagctc ctcgtttgtg tgagcgtggg tcagaccgcc 2820
aaagtaggac ttcatcgttt acctacctat tatcaatatg gtgcttgaat atattcctat 2880
aactgtagaa cagtgtggaa agtgatggta actttgaagt tgttcatgtt ttattggctt 2940
tgttttaatt gacactagta gagttttaat ggtctttgtg taaattttaa tggcttttcc 3000
attgtttttg cttctcttaa aaagtttaag aagaatatga cctcattaaa tgtgctgttt 3060
tatttggacc agtcacacaa aatgtctctc tagagttgac tttaaagttg tttacagaaa 3120
tttaaactca attccagaga ttgaagttgt ccaaacagct catgggctta gtgtccaaac 3180
ccctgcccag ccttcccttt ccaagttggt gccacctcca ggtagccatt ggtggttttc 3240
ctattactga tgtggctgtg gaatgataag gtcctagagg ggccctggca tttcaggaag 3300
cggacctggt attccctgac aaacattgct taggaaagag ggccggagaa taagaagcca 3360
gcacctcatc agtcagccct gcaatgtgag acttccgtag ctgttgagag tcactgcagg 3420
tgttctttca tcccatctga ttttaaccca tggttgagac gttccaagtt agatctgctg 3480
ctcttaggtg tggggctgtc cacattaggg aacttgcctc aaaaacagtc cacagtggca 3540
ataccggact tctgttcaag ctttttaaag tgctgagcct tacaaacccc tgaaggaagg 3600
tgacccttta agagaggatc atcttttttt atatttattt tcaccaaata gggtgatgag 3660
ggttggtttt tgttccctca acccatttgg gtaaaataac ggatctgatt agaaactgtt 3720
ttaaggaggg gctgggctcg gtggctcacg cctgtaatcc cagactttga gaggccaagg 3780
cggtcacgag gtcaggagtt cgagaccagc ctagccaaca tggtgaaacc ccgtctctac 3840
aaaaaataca aaaattagcc gggtgggaca cgcctgtaat cccagctact caagaggctg 3900
aggcaggaga atagcttgaa cccgggaggc agaggttgca gtgagccgag atcacaccac 3960
tgcactccag cctgggtgac agagcgaggc tccgtctcaa aaaaaaaaaa aaaaaattgt 4020
tttagcgctg ggtttcccaa ggtgggagag acagacccag cctggagctg gcccctggcc 4080
tgtgtgctga cttcttgggg tcctcaaacc actgtatttt tctgttgagc ctgtacttgg 4140
ggagagatca gtagcatttg aggaagtaag agaaaagaat catggtacct cagggtttct 4200
ttccctttac tcgctggcag ccattgtctg tgggcacctc atgtttttcc acactctact 4260
gggccgtgga ggtaacgatc acccaggcca gtctcctctg cctgggatgc gccctctgag 4320
aggaggccta gcagggcagg ctccctctgg gcatccctgg atgcagcctc tggacacatg 4380
cctcctttaa agtgtccggg tgcagctcag gttgagtgga ggtagaagga gaaacagaca 4440
tgtttaccac gcgttttcca aagctcctga tctttcccaa gattgtaact gaaaactgct 4500
gtctcttgtt ttgttcgttt tgggggtggt ggtgctggct gggccatgct tgtgaagtga 4560
tgtgtgtctc tgatttaacg gattcactgt tttctctgct aattgagaga gcgttattta 4620
cattatttat ttgttttgac acaagtgctt tcagtgtttt atcctagcta atggcttctt 4680
aaaggtaata aaacccttcc aacgtaattg gtcagataaa actttttttc ttgtatgctt 4740
aaataaagca attagtgaag cacttctatc caaaatgact tttttgtcct tttttaaaac 4800
caatttactg ttactggaaa ctttttgtac aataaagcaa tcacgcagat taaagaacat 4860
cctgcaatcc tagtattaat tttaaaaaaa 4890
<210> 65
<211> 2210
<212> DNA
<213> 人类
<400> 65
agtgacgtct ttgccccgcg ccgcgccgtc ccacccatct ccctggcctc cggtcccaac 60
ttcgcttctc tgctgaccct ctctcgtcgc cgctgccgcc gccgcagctg ccaaaatgtc 120
tacaggtcca actgctgcca ctggcagtaa tcgaagactt cagcagacac aaaatcaagt 180
agatgaggtg gtggacataa tgcgagttaa cgtggacaag gttctggaaa gagaccagaa 240
gctctctgag ttagacgacc gtgcagacgc actgcaggca ggcgcttctc aatttgaaac 300
gagcgcagcc aagttgaaga ggaaatattg gtggaagaat tgcaagatgt gggcaatcgg 360
gattactgtt ctggttatct tcatcatcat catcatcgtg tgggttgtct cttcatgaag 420
aaccagcgga actcaaaact gctgttcaag aaacctcttc aagacttttg acttagaacc 480
tgctatatta tcaagcttac ctactgttat ctctaaaatt ttttttgtgt taatgtaaag 540
ttgaatttct aggaaacgtg cctttgtttt ttaatatgca ctccaaatta gaaggccggc 600
cccgtccaca ttttgcacag tgcctttaca gatttacgta tgggctgatg aagaggcctt 660
cttaagttcc agagtgctat aatctagatg taatgttgtc actaattaat tgccattact 720
cccagttagt tacccttgtc atttggcatt attttcagaa ccacatttta aacctttggg 780
taatcagatt tccaacttat gccttccaga aaaaaacact actgcctaac acaaatctgt 840
gataacaaca ggctgtgcct tattttgata attttctgat tccctagaag agaaccctct 900
actttttgta agcactactg actctcgctg tatttaagat gctggtgaag agcttttgct 960
cttgcattag atttgaagat gtttacattg ttgttattgt tatgtatcac ttgctaaaaa 1020
tattgtttta atcagagata acctctttaa aaaaattttt aaagaactat ggctatgacc 1080
aaagcttcta ttttgccaaa aagttaaata ccgataaaat ggccttaagt gtattcctga 1140
cagttaaatt cagaaacgtg ccaaatggaa ctcaaggtgc cccttcagaa ttaaaatcat 1200
taccttgtgt gtgaaccttc tacatcttca taggcctttc ttccttttga aaggctgtag 1260
acagtgtggc tccccttctg attcagtatt ttgcatgggg gttagagaag gtttgaggta 1320
gactctgacc gtctcataaa agagttctac ccagcagttg gcagattatc agctgtggac 1380
tccagcatgt ttctgataat tatgcaagca acaattctgt agcctcaagt aagaccacct 1440
gtgaacttga tcattatctg gcccaaatat gaagataaac tataactttg gagtttgttt 1500
cctatttgta ttcacattct gcttcctaaa tcagttttct aaattatgcc tgcaattagg 1560
cattggtcag gggtgaatgg ctcttttcac agagagtagc caaccagaga cctttgcttt 1620
gatatcatca actgcagaga atgctgttga tgggaatgct ggaagcagaa actttgtcat 1680
cggaaaaact tttcttgtat gcatgagact caacatcagg atccacagct taaagatggg 1740
aattcaggta tgaaagaaaa caggcaagga ggcactgagg gagaaagaca cagactttat 1800
cgctctgtgg ctcattgtta ctggaatatt ctaaaactct tgttcacatg ctattatgac 1860
ttataaagca gcaacagctg aggcgcacca ggacacagct tccatttctt taacgtctgt 1920
tcccttaaca tcgctgaaat gatttactgt tgaagagatg ccttgcggtg tggccagctg 1980
tgaggagaaa gcagctggca gtgttaggac attagtccac cttcagcgca gggtctctgg 2040
ccgggtctga ctcagaaacc ttggtactcg ccccttggcc acagtgccca gacccatgta 2100
acccactggc tcctgcatta acccagaaat acctcgcttc tatctgtgca cttagctggg 2160
aacttaccca ctgtaatcac ctaaataaag tgtttataaa catgaaaaaa 2210
<210> 66
<211> 3140
<212> DNA
<213> 人类
<400> 66
agtaagttcc agcgcagcta gaccgcgggg tagtcggcgc gaggcggagc ttggcagttc 60
cgtccacttc agccgcagcg tccctcgccg ggtgtctcgc cgcagcctcc ggagaggaac 120
agaccctcac tctctctgtc agaaaaatgt ctgctccagc tcagccacct gctgaaggga 180
cagaagggac tgccccaggt gggggtcccc ctggccctcc tcctaacatg accagtaaca 240
gacgactaca gcaaacccag gcacaagtgg aggaggtggt ggacatcata cgtgtgaacg 300
tggacaaggt cctggagagg gaccagaagc tgtcagagct ggatgaccga gctgatgcct 360
tgcaggcagg agcatcacaa tttgagagca gtgctgccaa gctaaagagg aagtattggt 420
ggaaaaactg caagatgatg atcatgctgg gagccatctg tgccatcatc gtggtagtta 480
ttgtaagtaa gtatcgctga agttgctggt ggggtgaaga ggtgggaagg tcctggagtc 540
ttctccctgc ctgcctgcct gcctggggag tggggctgct ctgactgagg tatggagacc 600
gctgctatgg gatcgtcacc tggttcggga cgggggaagg gcagagacaa gggatttctt 660
tgatggacaa gccttccccc tgcaacgcat tgcagggaga tggcgcctcc tgttctgagg 720
aagtggggct atgctgtgtg tcactggctt gggttggagg gagaccatgg ggatggggca 780
cttaacaatg gagagacctg aatgtctggt aacttggtgt aattcaccct cttgttttct 840
cctgtctctt tctcttttcc gtctgggact tcctgattcc tgtgtccagt ctactttttt 900
acttgagaat gtaccacccc ttccctgttg tccattgcca tccacattca tgtcctctgc 960
cctctgtttg ctctctcaac acacttcccc acccaccgtc ctccattcca gcccaggctt 1020
ctccatcacc cattcctcct ttttcgttgc gttcatttgc actctgtccc tcaacactag 1080
aaatgctgct cgtggcacaa tctaagtcat tacccgaaga gcaacagctg gcgcctcctc 1140
cctgcctgct ttttctgtac tctcaagttc ccccaaagcc ccaaagagtt ggaggccaag 1200
ggaaggggca gggaggggag tggctgaggc gaagtaccca tgaagctgcc cagacttggg 1260
aggagaagag tatcggtgcc catggtgact tctagaaaac ctggccactg gtaggagcta 1320
gggaggggct gggaagatgg cagctcactc agtactgcct ggtcatgtgg agctttcctt 1380
cctggaccag gcctggagag ggtcctgggg gtggaccaaa gtccaacttg gtttcagtgc 1440
agtacccttt tcgaaagtaa aaacttgttt tttgtagtta tttctaatct gttcgtccag 1500
gattttccgt gtctttgggg atcttacaac tttactttgt tctccagagg cctggagaac 1560
acttagggat tgtgaaaata gcaggacttg tttccatcct agaagcagtc ccatgtgctt 1620
ctagctggaa ggagctttct cttctttaca ttttctacag cattctgtat gagggcacca 1680
aataaatcca tctagctggt agttttatct agccaaataa tttaacctag ctcccagtta 1740
attgttggca taaagagaga gattgcctgt tagttataga gaaacagtga gtcaagtgct 1800
taatttgaaa gtaacaagct cagaggaagc cactccttgc cctcgttaaa gagggtcctg 1860
ttcctctctt cctgttgatg aaggagcgtg agggtgttag cagtgtgaga tctttggaca 1920
cccatggaat cctttcctcc acaccacccg tgcacttgcc aaagacaggg atgaggcaag 1980
tggttcttcc tggggcccgg ccgatcctca ggatgcagag aagtcatgta gacccaccag 2040
ccccaccttg gggggaggcg tgccagcctg tgtcaggtgt gcttgtgtat tgctgtgctg 2100
tcatggggcc ctctccttga gagccgcctc tctgttcttc ctgtagtata ttcccctttg 2160
aaccaccctt tcctgtctga attctacttt gcctcctttc tcttcctcct ctttgcatgg 2220
tttgtgtgta tagacagtgg aacctgagga tgggatctgc tcagcctatc ttcggggcaa 2280
ttgctgagct tcaggatggg ctattaatgt gggataagcc caggtgcaag gggaggaggg 2340
caggctggga acagagcgga gaatgcccat ggccctttat tccttcttcc ctcggtccac 2400
gaacaggaag aggctgaggc catgctgggc agggtctgga tgcccacttt ccatgcagca 2460
gcatttcatt gctcaaaacc atccttcctt tcctttcgcc cttgtttccc acattccctt 2520
cgtcctgccc aagggcggga ctgaagagct ggaagaaagc agtcagtacc ctcccaacgg 2580
cccccctcga aggtctccac tctcctctgg gctcctcctt gcctaatgca gggggtcacc 2640
gctggagaag aaccaccact gtcctcgatg tgtcccaagc ctggagcgaa tccgtcctct 2700
tggctctccc agccctatca caggaatcat tcctgggttt ctgtccctct gaggctcacc 2760
aggtgtagtt ggccttgttc tttgggggta ttagcccttc tactttcttt ctcacccacc 2820
ctgtaccctc ttctgtgtgt ctctgctatc cccctttcct cccaccaccc atgtgcatga 2880
gcaaatgtgc aacaaaaccc tgggactttg cagtcaaatg aagctgagct tcccacatcc 2940
cgttcttcgg tttgccatga gacgatgtgg ggtttccact gtgtgtctgt catcacctct 3000
ttgtcttttt ttcctaaccc tgatctcata cttgtataga gtaataacaa cagttgtact 3060
tccaccaaag gcatgtggca tatttaccaa tgtcatgtat tctgaacaaa ggcaaaaaat 3120
acaaattcct accattaaaa 3140
<210> 67
<211> 1090
<212> DNA
<213> 人类
<400> 67
agtaagttcc agcgcagcta gaccgcgggg tagtcggcgc gaggcggagc ttggcagttc 60
cgtccacttc agccgcagcg tccctcgccg ggtgtctcgc cgcagcctcc ggagaggaac 120
agaccctcac tctctctgtc agaaaaatgt ctgctccagc tcagccacct gctgaaggga 180
cagaagggac tgccccaggt gggggtcccc ctggccctcc tcctaacatg accagtaaca 240
gacgactaca gcaaacccag gcacaagtgg aggaggtggt ggacatcata cgtgtgaacg 300
tggacaaggt cctggagagg gaccagaagc tgtcagagct ggatgaccga gctgatgcct 360
tgcaggcagg agcatcacaa tttgagagca gtgctgccaa gctaaagagg aagtattggt 420
ggaaaaactg caagatgatg atcatgctgg gagccatctg tgccatcatc gtggtagtta 480
ttgtaaggcg ggactgaaga gctggaagaa agcagtcagt accctcccaa cggcccccct 540
cgaaggtctc cactctcctc tgggctcctc cttgcctaat gcagggggtc accgctggag 600
aagaaccacc actgtcctcg atgtgtccca agcctggagc gaatccgtcc tcttggctct 660
cccagcccta tcacaggaat cattcctggg tttctgtccc tctgaggctc accaggtgta 720
gttggccttg ttctttgggg gtattagccc ttctactttc tttctcaccc accctgtacc 780
ctcttctgtg tgtctctgct atcccccttt cctcccacca cccatgtgca tgagcaaatg 840
tgcaacaaaa ccctgggact ttgcagtcaa atgaagctga gcttcccaca tcccgttctt 900
cggtttgcca tgagacgatg tggggtttcc actgtgtgtc tgtcatcacc tctttgtctt 960
tttttcctaa ccctgatctc atacttgtat agagtaataa caacagttgt acttccacca 1020
aaggcatgtg gcatatttac caatgtcatg tattctgaac aaaggcaaaa aatacaaatt 1080
cctaccatta 1090
<210> 68
<211> 5000
<212> DNA
<213> 人类
<400> 68
cagctagccg cctcctgcag gggctcggga gagcaattcg gcggcccctg cagggcagct 60
gaagccatgg aagcctccgc aggtcgctga tcagggccag gcggctgcag cagcgactgc 120
agaggcgctg cgccaagccg ggccggagtg gtgcgagccg gcggggctgc ggagggccag 180
tggactcagc ccccgggata ccgcccatcc caccccttac tcggacccac agcctcatgg 240
ccatgtccct gccaggaagt agacggacct ctgctggatc acgcaggcgc acctctccac 300
ctgtgagcgt gcgggatgcc tacggcacct cttcgctcag cagcagcagc aattctggct 360
cctacaaggg cagtgacagc agtcccacgc caaggcgctc catgaaatac acgctgtgca 420
gtgacaacca tggcatcaag cccccgaccc cggagcagta cctgaccccc ctgcagcaga 480
aggaggtgtg catccggcac ctgaaagccc ggctgaagga cacacaggac cggctccagg 540
accgggacac agagattgat gacctgaaga cgcagctgtc acgcatgcag gaggactgga 600
ttgaggagga gtgccaccgc gtggaggccc agctggccct gaaggaggcc cgaaaggaga 660
tcaagcagct caagcaggtc atcgacactg tcaagaacaa cctgattgac aaggacaagg 720
ggctgcagaa gtacttcgtg gacatcaaca tccagaacaa gaagctggag acgctgctgc 780
acagcatgga ggtggcccag aatggcatgg ccaaggagga tggcactggg gagtcagccg 840
gtgggtcccc tgcccgctcc ctcacccgca gctccaccta caccaagctg agtgacccgg 900
ctgtctgtgg tgaccgccag ccgggtgatc cctccagcgg ctctgctgag gatggggcag 960
acagtggctt tgcagcagcc gatgacacac tgagccggac ggacgcgctg gaagccagca 1020
gcctgctgtc gtcgggggtg gactgtggca ccgaggagac ctcgctgcac agctccttcg 1080
gcctgggccc ccgcttccct gccagcaaca cctatgagaa gctgctgtgt ggcatggagg 1140
ctggtgtgca ggccagctgc atgcaggagc gtgccatcca gacagacttc gtgcagtacc 1200
agcctgacct tgacaccatc ctggagaaag tgacccaggc ccaggtctgt gggacagacc 1260
ctgagtcagg ggacaggtgc ccagagctgg atgcccaccc ttcagggccc agagacccca 1320
actcagcagt ggtggtgaca gtgggtgatg agctagaggc cccagagccc atcacccgtg 1380
gacccacccc acagcggcct ggtgccaacc ccaaccctgg ccagtcggtg agcgtggtgt 1440
gccccatgga agaggaggag gaggctgccg tggctgagaa ggagcccaag agctactgga 1500
gccgccacta catcgtggat ctgctggctg tggtggtgcc ggccgtgccc acggtggcct 1560
ggctttgccg ctcccagcgg cgccagggcc agcccatcta caacatcagc tccctgctgc 1620
ggggctgctg cactgtggcc ttgcactcca tccgcaggat cagctgccgc tcgctgagcc 1680
agccgagtcc cagcccagcg ggcggcggct cccagctctg agggggccca ttccggcagc 1740
ggcgcctgcg gcctgaccac tgattgtagg gatgccgttc ccccctccct tctcccatgg 1800
gcatcatctt atttatttag ttttgggtgt ggaactgttt ctttttttca agatgttaaa 1860
acagtcccgt ggaaggagca ggggttggag aaaggcatcc caaagcttcg atggagagca 1920
gggaaggggg acccaaggca ggaggtacac cagctggaca aattgcaggg aggggaggga 1980
gcgagggcca acccggcccc tctgtcccct tggctcttca gacagggcca gccctgctca 2040
ggaagtctct ggctgtcttc atgtggggaa gccgggcttg agttgcccat aggcccctgc 2100
cctgcaccat cctgtccagt gccctgcgca ctccatgccg tctcttccaa gccaccttgc 2160
ccgcagccca ggctcctggg ccagtgctct ctcctcaaat ggaggcagcc atggcctgaa 2220
gtgcagatca ctgacccagg gctcagagca gaggccagaa ccactgggcc ggccggcatt 2280
ccagcctccc cagactgctg cccaccttgg gactcaggag ctcagtcaag gccacaggct 2340
ggaggagaga cggggctggg cgcaaggtgg cggagggcag tgtgggttct gtgtctgtct 2400
gttcatccca ggctttcccg tcatcccttt cctcttggca cttctgggtg tgtcagtcat 2460
tattcctgtg aggtagctaa gcccggcaag ctcagtgctg gggtaggagg gcctgcctga 2520
gtcccagctc ccagctggag aatccaccag cacaagaaga ggaggcaggg gcagaaaccc 2580
aagggggctc ccccagcctt ccaaggtgag gccatctcat ctgcaggctg ggaggcaggg 2640
ctggactcag gaacccacag cttactgaaa aagccagagg ccatgactgc ccccagaaac 2700
ttgccccgag tttctctggg gccctcgggc ccaacttctg ctttgcacta tgttcacttt 2760
ggggttggtt ctcagccatc caagggtctc cagtgaggtg gctgcttgct gtctgagatg 2820
agggttccta aaccttaaac ctctctgcct ctggaggagg gtggggtatt ctggcaggat 2880
gaatcgcagg atggcgcgta ctgaagccac gatgttcatc caggccaaag cagggtgtcc 2940
tgggataggt ttcctaggca ggggcgtggc agagcaggta ggcgccctgc agcctccctg 3000
ctcccagccc aaggccagtc ggcctgggaa gttcactgcc ccaactcttt tcccgggacc 3060
atactgagtc ccccagccac gctgctgaca ttaccattat tattttacca agtaaactca 3120
ctccttttcc cccacagggg ttacacccat ctggttgtcc cacccactct tcagaggcta 3180
ggccccacct ctgggggttg gagggaccct gtgtcttact cgcccctctg gcctaagggc 3240
cactctggtt atctgccaag gttgcttgcc ctcaccccaa tgctccaaca gccattgcct 3300
aactcatggg ctctgccctt ctgctcggtg ccctccacgt gaggcggggc acctgcatgc 3360
actgggaggg ggcggctggc ccagccctcg gggcaggagc cccctctgcc acacgctttg 3420
tgcctccaaa gctccccccg ccttggtcag ggcctcagac cagccaacct ttgtggaata 3480
agccccagcc cagccaaacc aaacccagat gcctgaggcc tggctggggc tgcccccgca 3540
ggacactgtg gccatgccac ggagggggca gtggacaaaa ccaatccaaa gccaagccgg 3600
gactggctgc ggacccagcc tcctgtgccg cgcactcacg gagctgcgta gtctcctcag 3660
acatagtcaa agctttgccg agaaaagaaa tgtatgaact atatttgaca acataaaatc 3720
tctctatttt tcaccactgg aatttagtca agcttcaggc ccctctgctc ctgtctgtgt 3780
cttgcgtctg tggccttcct attgtgtctt gtgttttggt ggatgtgaca gggctggggc 3840
cacagtctac tctgtctctg ctgctagaga agccacctgt ggaggactgg gctgtggttg 3900
ggcctgaggc ctgtggagga ggtgagtgta gccagcagcg gccgtctact cctgttctgg 3960
cctgagacca ccggtgtggg tcacgagggc cctggcccac agtgttgagg gtcctctctt 4020
tcgggggctc tcctggggcc ttcgatgggc ttttcttctt gtcagtggag ggagcagctc 4080
cccactcagc cctgggacag gccctgggac tgtggtggcc ggtggccctg gcccagctct 4140
ggagtgcatg tgtgtgtgct cagatcccgc atctatgcaa aggtgcaggc tgcctgtgag 4200
gctccaggcg gtggaggtgc ggcagctgct gctcaggtgc catgccctga agaggcaggg 4260
tacacatggg gctgggaggg caaagatggg gcggggcctc cccctgagag agctcaccct 4320
ccacagtgac ccttttcctt cctgcctaat acctcctccc gttgggctgt gacttttcct 4380
cctgccctca gcctctgaaa cagaaatctt tggggcctcc cctttcccca gcgtctggca 4440
agagctgatg aggtcctgag gaacagtgtc cccaggaacc accttctgga gcctagcggc 4500
cagacgtggc ttctcctgag ttctagggct cgggccagag tggcactact gcccggccag 4560
tccaggctca ggcaggaatc ggacgctggg gcccgggctc tgcacagaga gctgggcttg 4620
agtggagttt attgtagatt tctcccaagg ggatcactta gcttctcact gacacaccct 4680
tcccaattgc cacaagcgca ggggtatctt acagcacttt ggggaggggt gggacaaact 4740
gcaaggttct ggggccaagg cctacccagg ggcctctgcc cagagaactc acaaccccct 4800
ctctgaccta ggggacaatg caaacaggtc acagtgcatt cccatattag gccatcccct 4860
tcacgaagaa ttcaggggat gtgggaagtg gggaggcggg gagggatctt gactcttgtc 4920
tcctttgtcc ttttgttcag acagagttgt acctgcagca gacaactctg aattaaagca 4980
tgaaaacaca gcaaaaaaaa 5000
<210> 69
<211> 2770
<212> DNA
<213> 人类
<400> 69
gattgcgagc caggaggagg aagccggcgg tggccccgtc agcagccggc tgctgagagg 60
ccggtaggcg gcggcggtcc cgaggggcgg cggccgcgct gctccctgag aacgggtccc 120
gcagctgggc aggcgggcgg cctgagggcg cggagccatg aagctgtaca gcctcagcgt 180
cctctacaaa ggcgaggcca aggtggtgct gctcaaagcc gcatacgatg tgtcttcctt 240
cagctttttc cagagatcca gcgttcagga attcatgacc ttcacgagtc aactgattgt 300
ggagcgctca tcgaaaggca ctagagcttc tgtcaaagaa caagactatc tgtgccacgt 360
ctacgtccgg aatgatagtc ttgcaggtgt ggtcattgct gacaatgaat acccatcccg 420
ggtggccttt accttgctgg agaaggtact agatgaattc tccaagcaag tcgacaggat 480
agactggcca gtaggatccc ctgctacaat ccattaccca gccctggatg gtcacctcag 540
tagataccag aacccacgag aagctgatcc catgactaaa gtgcaggccg aactagatga 600
gaccaaaatc attctgcaca acaccatgga gtctctgtta gagcgaggtg agaagctaga 660
tgacttggtg tccaaatccg aggtgctggg aacacagtct aaagccttct ataaaactgc 720
ccggaaacaa aactcatgct gtgccatcat gtgatgcagc ctgccagagg cccaatgctg 780
gaatggcacc atcattcaca tcagaactgc agcccctgga aaagaagaga cagccataga 840
cgaggagcca gagtgggggc agactggcca tttttatttt gaagttcctg cgagaaatgg 900
atggtggaag ggtggcgaat gttcaaattc atatgtgtgg tagtgattct tggaaagaat 960
ttgaggtccc caaaggtgta tttttgggca aatgaaacca taaactccga ctggcttctg 1020
tagatgccaa agggctcttt ttcagctaac cctgggaagg ctctgtggga gggaggtcgg 1080
agccagctgt ttctcgatct ttggtatatc tttggatctt atttgtacat taatgatatt 1140
aacactccag tggggggtgg ggagtccctg atgctagggc tggggtgggt ggagtttgaa 1200
gactcttggg aaagcctctc ctggggccac tgttgggggt gggagtgagc ccaccacaga 1260
ggccacaggc aggcccccac ttcaggccca aggcctgggg cggggggaac agtcactggg 1320
tctcagattc tgagactgtt gtttagctta cctttctgct aggattggct tcccgcagag 1380
ggcagggccc atcctaagca gcttccaagt cccacaaagg tggcttgtgg gaggatttgg 1440
aaggagctgc attgtgggcg gggagtgtgt gggttgggtt cgtaccagca agtagactag 1500
gaactgagcc caggaaaggg ggatgttttc ctggtgtttg gatggtcagc tgggagtgtc 1560
catcatcagg ggaagatcaa acacaggtgc actcagctgc ccagggcctc tgggacactt 1620
gccttgactt gcaacttgcc ttgaacatca cgatcaaagc agcaggtgct gtggtctctc 1680
aaaattgatt tttatttgac tctgtggctc taagactgcc ttgaaccgcc tgaggcctat 1740
gcatctgaac aagtgggtct ctcccttgag caccaggagt gggtgccagc cggccccgag 1800
gattcccagc accccaccta tggtcttgcc agcataggct tgctagttcc ttcttggtca 1860
gaggtagctg cagagggggg aggccaaggg tttggtctaa gctgtgccct gccacctggc 1920
aggaggccca ctcactgccc aagtcatggc aacaggctgg agcagcccag gagatgggcc 1980
taaaatgttc tggatccctt gggtcctagt gttatgttcc agtctgccca cctgtgctca 2040
ggatgcagcc ctgggatcca gcacccatgg aagcttctgc tgggatggtg tcacctatgg 2100
gttttgaacc agtgtggtat ggtccttggg agctctgctc tgagcttgcc acactgctga 2160
gagcacccac tgtcctgacc agagtctcag tggtcctgac ccccaatgtg ggcaggggct 2220
gggcaggagg gtggggtctg ctgtgggttc agaggactcc acctcctggc tggtttacct 2280
gctgctgccc attttctctg ggtactgctg gccagaggac tttagcctac ccctgaagag 2340
cctgtccatg tcattttcct actgccatag ataccctaag cccagggccc cttgaggccc 2400
agactcagcc tgcccactgg tgccggagac ggagtggagt gggcctggat ccgagggatg 2460
ctacctctcc ctttcccact tgaggaccct ggggagagat gggggcgggg aaaatggagg 2520
tatgaatttg gggtaagagg aagtgagatc tccgcttgca ggtcagcccc tgccttgcag 2580
ggcgggctgg cttgactcag gccctgtgag atagagggcc cagcccagcc ccacccacag 2640
atcccctgct cctgttgtgt tctgttgtaa atcatttggc gagactgtat tttagtaact 2700
gctgcctaac ttccctgtgt tctatttgag aggcgcctgt ctggataaag ttgtcttgaa 2760
atttcaaaaa 2770
<210> 70
<211> 1390
<212> DNA
<213> 人类
<400> 70
gggaagaaaa gggaattcca acctgtggaa ccttgggggg tccccggggt cggcgccttc 60
ccattgactg tgggcggtgc aagggacgga gcctctggcg gctcgtgggg gtgttggggt 120
ccgcaggggg agggagggga gtgtcagagt gtgagcgggg tacgggaatt ccaaatttga 180
gggcctcccg gctctggcgc cggggaggga gagctcaggc cgccatgcgg gacaggaccc 240
acgagctgag acagggggat gacagctcgg acgaagagga caaggagcgg gtcgcgctgg 300
tggtgcaccc gggcacggca cggctgggga gcccggacga ggagttcttc cacaaggtcc 360
ggacaattcg gcagactatt gtcaaactgg ggaataaagt ccaggagttg gagaaacagc 420
aggtcaccat cctggccacg ccccttcccg aggagagcat gaagcaggag ctgcagaacc 480
tgcgcgatga gatcaaacag ctggggaggg agatccgcct gcagctgaag gccatagagc 540
cccagaagga ggaagctgat gagaactata actccgtcaa cacaagaatg agaaaaaccc 600
agcatggggt cctgtcccag caattcgtgg agctcatcaa caagtgcaat tcaatgcagt 660
ccgaataccg ggagaagaac gtggagcgga ttcggaggca gctgaagatc accaatgctg 720
ggatggtgtc tgatgaggag ttggagcaga tgctggacag tgggcaaagc gaggtgtttg 780
tgtccaatat cctgaaggac acgcaggtga ctcgacaggc cttaaatgag atctcggccc 840
ggcacagtga gatccagcag cttgaacgca gtattcgtga gctgcacgac atattcactt 900
ttctggctac cgaagtggag atgcaggggg agatgatcaa tcggattgag aagaacatcc 960
tgagctcagc ggactacgtg gaacgtgggc aggagcacgt caagacggcc ctggagaacc 1020
agaagaaggc gaggaagaag aaagtcttga ttgccatctg tgtgtccatc accgtcgtcc 1080
tcctagcagt catcattggc gtcacagtgg ttggataatg tcgcacattg ttggcactag 1140
gagcaccagg aacccagggc ctggccttct ctcccagcag cctggggggc agggcagagc 1200
ctccagtcgg accccttcct cacactggcc cctatgcaga agggcagaca gttcttctgg 1260
ggttggcagc tgctcattca tgatggcctc ctccttcagg cctcaatgcc tgggggaggc 1320
ctgcactgtc ctgattggcc gggacacacg gttttgtaaa aaattaaaaa acaaaaaaag 1380
agcataaaaa 1390
<210> 71
<211> 1920
<212> DNA
<213> 人类
<400> 71
ggcgcggagc tcgggcggcc gtggaggaac tcagcctcgg ccgcaggagg cgccgggagc 60
ggagccgccg ggagtcgcgc aacaggtttc cttctccatc gctgcgccca caggggacgc 120
gcgccctgcc gggagagggg cttctcggtt cgcactctcg ctcccagtcc aggcaaaatg 180
aaagaccggc tagcagaact tctggacttg tccaagcaat atgaccagca gttcccagac 240
ggggacgatg agtttgactc gccccacgag gacatcgtgt tcgagacgga ccacatcctg 300
gagtccctgt accgagacat ccgggacatt caggatgaaa accagctgct ggtggccgac 360
gtgaagcggc tgggaaagca gaacgcccgc ttcctcacgt ccatgcggcg cctcagcagc 420
atcaagcgcg acaccaactc catcgccaag gccatcaagg cccggggcga ggtcatccac 480
tgcaagctgc gcgccatgaa ggagctgagc gaggcggctg aggcccagca cggcccgcac 540
tcggcagtgg cgcgcatttc gcgggcgcag tacaacgcgc tcaccctcac cttccagcgc 600
gccatgcacg actacaacca ggccgagatg aagcagcgcg acaactgcaa gatccgcatc 660
cagcgccagc tggagatcat gggcaaggaa gtctcgggcg accagatcga ggacatgttc 720
gagcagggta agtgggacgt gttttccgag aacttgctgg ccgacgtgaa gggcgcgcgg 780
gccgccctca acgagatcga gagccgccac cgcgaactgc tgcgcctgga gagccgcatc 840
cgcgacgtac acgagctctt cttgcagatg gcggtgctgg tggagaagca ggccgacacc 900
ctgaacgtca tcgagctcaa cgtacaaaag acggtcgact acaccggcca ggccaaggcg 960
caggtgcgga aggccgtgca gtacgaggag aagaacccct gccggaccct ctgctgcttc 1020
tgctgtccct gcctcaagta gcaggccggc ccgggccgcc accgcccatc ccagaccatg 1080
gagcgcgctg ggaaggacgc accaaagccg ggagctctgc cctgcaggga gttgccccaa 1140
ccctttccgg aactcagtct ttagaaaaga aacgccaggt tcaagaattg caaaccagcc 1200
tgtgcttgga aagatggtta gttgataccg tccgatgatt cttcagtaaa gatagattcc 1260
cacaaagttg tgcaatgtca ttatatgaca ccttgcactc ttaccgtctt gacagaagcc 1320
aagtaaggaa ctgaagttgt atctgactgt agggtgaatg tctgaggcct gcctcctaat 1380
aaagactcaa ggaggaagtc aattgggcat ctgctaatag aatgaactca tgatggaaac 1440
ttcagttcat ttactttgtc ctgaaaattc cctggttctg ttccattttg agcgaaattg 1500
gccttgggaa aaaccacgtt cttcctttcc gattcttcat ccggtctacg ctatgcaatt 1560
cctccccaaa tatagatctt atttctgctc atttccccta cttattaaaa tcacaccaaa 1620
cacttactat tttcttatct ctttcacttt ttaaatatct ttcaccaggt tatattttgg 1680
tattattttt ccaaacattt ttaagcactg aatatcgaac aagcactcaa attgaagtat 1740
cagtcatgtt ttgtgtattt ttcgctgata aaaattattt aacatttata tttttacttg 1800
attacatatg cacatgtatg taaatgtaaa atactaatat tcactaatat atgtacataa 1860
tgatcaattg gtttaacttc ttttatgtaa gtatggtata taaatttcaa gacgaaaaaa 1920
<210> 72
<211> 1912
<212> DNA
<213> 人类
<400> 72
gatgtttggg tgcccgcccc gcccgcctcg cccgccgtga gcgcccggag cggtccgcga 60
gccaccgagg cccagctcag tgtggaggct gctggccctg ccatctgtaa gaagatgtca 120
tacggatcca tcgcccgtgg aggtggcctg gggagccgtg gccctctcgg gggaccttcg 180
agacaaggct gtcagcccct agagtgcgct agatgttgga ccgagtatgg aatccgccat 240
ttcccctgcc cgtcgccaga gagcaagctg cagaacccct gtgtggggaa ggacggggaa 300
ggtgatctgg ggccagcagg cacgcctatt gtcccaaggg ccaggaagcg agggcctggg 360
gttgcccctg aaggcagccg gatgccggag cccacctcat cacccaccat tggcccgagg 420
aaggactcgg ctgctgggcc ccatggccgg atggcggggc ccagcgctac ccgggccaag 480
aagaggaagc ccaacttctg cccgcaggag accgaggtgc tggtgtccaa ggtgagcaag 540
caccaccagc tgctgtttgg cacggggctg ctgaaggccg agcccactcg caggtaccgc 600
gtgtggagcc gcatcctgca ggccgtgaat gcgctgggct actgtcgccg cgacgttgtg 660
gacctgaagc acaagtggcg ggacctacga gccgtcgtgc ggcgcaagct gggcgacctc 720
cggaaggcgg cccatggccc cagccctggt tccggcaagc cccaggccct ggctctcacg 780
cccgtggagc aggtggtggc caagaccttc tcttgccagg ccctgccctc cgagggcttc 840
agtctggagc cgcccagagc cacccaggtc gatccgtgca acctccagga gctgttccag 900
gagatgtcgg ccaacgtctt ccgaatcaac tccagtgtga cctccttgga gcggagcctt 960
cagtccttag ggacaccgag tgacacgcag gagcttcggg acagcctgca cacggcacag 1020
caggagacca acaagaccat tgcagccagc gccagctccg tgaagcagat ggccgagctg 1080
ctgcgcagct cctgcccgca ggagcgtctg cagcaggagc gtcctcagct ggaccggctg 1140
aaaacccagc tctcagatgc cattcagtgc tatggagtgg tgcagaagaa aattgcagaa 1200
aagtccagag cgctgcttcc catggcgcag aggggcagta aacagagtcc ccaggccccg 1260
tttgccgagc tggctgatga tgagaaggtc tttaacggga gtgacaacat gtggcagggc 1320
caggagcagg cgctgctccc ggacatcact gaagaggacc tggaggccat ccggctgcgg 1380
gaggaggcca tcctgcagat ggagagcaac ttgctggatg tgaatcagat catcaaggac 1440
ttggcctcca tggtgtcaga gcaaggagaa gctgttgata gtattgaagc cagccttgag 1500
gctgcgtcct cgcatgcgga ggcagcccgc cagctcctgg ctggagccag ccggcaccaa 1560
ctccagagac acaagatcaa gtgctgcttc ctatcagctg gagtcactgc cctgcttgtc 1620
atcatcatca tcatcgccac ctctgtccga aagtgatgct acccgtgcat cggccgctga 1680
accgtcagct ggctgtggtg tgggctctcc agccccgagc acccctcctg gcccggagct 1740
gggagctgat ggagtccgct gcgttgtcag ctgatgccgt cacctggcct gcaatggacc 1800
cgagagcttc acagctgcct gctgtcctcc cctgcactga ccccactcgc ccctgtgtcg 1860
gccccagctg agcacccgaa taaaccgctg tggcttatcc aaaaaaaaaa ag 1912
<210> 73
<211> 2307
<212> DNA
<213> 人类
<400> 73
cgcgactagg gtgcagcgcc aggtccggtg ttggggtgtc cgagttgccg ccggagagga 60
gtggcctcgc ccgcttgagt tttgattcat catggataat ctgtcatcag aagaaattca 120
acagagagct caccagatta ctgatgagtc tctggaaagt acgaggagaa tcctgggttt 180
agccattgag tctcaggatg caggaatcaa gaccatcact atgctggatg aacaaaagga 240
acaactaaac cgcatagaag aaggcttgga ccaaataaat aaggacatga gagagacaga 300
gaagacttta acagaactca acaaatgctg tggcctttgt gtctgcccat gtaatagaac 360
aaagaacttt gagtctggca aggcttataa gacaacatgg ggagatggtg gagaaaactc 420
accttgcaat gtagtatcta aacagccagg cccggtgaca aatggtcagc ttcagcaacc 480
aacaacggga gcagccagtg gtggatacat taaacgcata actaatgatg ccagagaaga 540
tgaaatggaa gagaacctga ctcaagtggg cagtatcctg ggaaatctaa aagacatggc 600
cctgaacata ggcaatgaga ttgatgctca aaatccacaa ataaaacgaa tcacagacaa 660
ggctgacacc aacagagatc gtattgatat tgccaatgcc agagcaaaga aactcattga 720
cagctaaagc tactgctgtt cttctttatc atttattcac ttccgtagct cctccttgaa 780
agttattacc ttttcagagt ttaagttttc ggttccacgc tcttctaatt gggagataat 840
atggaagaag ggccagagca gttacagccc tccttctttt ttgttttctg ttgagggccg 900
actgctgctc tgccttcctt ctagtatttt ctttctcaat tcatacgctt agattggttt 960
tcatatgtca tgtttagtgt tttcatcctc ctcatatact tcagcaggtt cttttgcttt 1020
caagatttgg aagcattgcc aaagacagcc atgaagaagg aagctgtaga ggtgtttttt 1080
gttgttgttt atttttgctt ttgtggttga gggaaggaca agagataaga ggttgttacc 1140
tcagtaaaaa ccttcaggcc acaaagcaaa aagttgcata gccacaacga agatctagtt 1200
ggatatagtt tttgatttaa gttgcagtta tagccaattt aggctaatgc ttggttttgg 1260
agcttttata cacaacgttt ttgttaggca tcacagtttt gcaacctctg ctccaaagag 1320
aaaaatagaa tgagttttct ttcttttttt tttttttgga gtcagagtct cgctctcttg 1380
tccaggctgg agtgcaatag cgcgatctgg gctcactgca acctccgcct ccctggttca 1440
agcaattctc ctgccttgcc tcctgagtag ctgggattac aggcgtgtgt caccacgctc 1500
ggctaatttt tgtattttta gtagagacag ggtttcacca tgtcaagctg gtcttggact 1560
cctgacgtcg tgatccaccc gccttggcct cccaaagtac tgggattaca ggcgtgagcc 1620
actgtgcctg gctgagtttt cttaaagtga gcttaatttc tgaactctta gtgattcata 1680
tatgtacata aatctgtgat cccatttctt attgcaccat tcaggaacac tttatataaa 1740
tgagtggctt tttatttcat attattagta gtatcatggt tccattacag gcctattaac 1800
atcatacatt gtcattagtc tttgaagaaa aaatatgtaa atatatatgt gtaacatgag 1860
aatttctctc taaagcaggg cttaaaattt tttggaaaag tttgacaaag cataccacat 1920
gaattcagat ttacctcaat gctaagaatt atgtttagtt aggaaaaagg aaagtcattt 1980
tgacctcagg tagaaaaata gattgctttg agttttatgt agctttagac tttaaaaagt 2040
tagaatttat tctgtaacta aaaattattt gaaaaaatta tgcctctggt ttaattattg 2100
gtgattacac actctttctc ttacccttgt gtattgaact atgtccataa tcaagttgat 2160
gtggatcctg aaaagtgtta tgaacatctg attggtattt gtcacattta ttttaaaatt 2220
agcatctgaa cacttcaaag ctgtcagtgt gtattggttt caccaataac cactgcttga 2280
tccttacaat taaatttttt aactaac 2307
<210> 74
<211> 2920
<212> DNA
<213> 人类
<400> 74
actctatgtc tcctctcgtt ggattgtgac accgggaggt cagggaactc caggaccttg 60
ttctctgctg gattcgcagc aaccagcaca gcacgtaggg cgtagttggt gctggatgga 120
tgtttgttga atgaatgaat gatgaatggc tggcaccttg tctgctcatc cctaactcct 180
gttccttcat ctgtgcagcc ctaatctttg tttcctcatc tgtccatccc tttatttgtg 240
catcctcatt cttagcccct tcactgccct tctccatctc ttcctccttg ttcatttgtc 300
cctgttctct gtcctctact ccactcatgc ccatctctgt ccccttgact tacccagtcc 360
ctgctactat ctccatccct aatttctgcc ctcttgtctg tctactccta attccttttc 420
cttgtccatc cctaatacct gtcaccttgt ccttcttcct cgaatctcca tccctaatcc 480
atctgcccct aatctctgtc ccctttgccc atccttcctt ttctcggtgt ctctttccac 540
ccttatctcc acacctgccc accctgcact cccattctgt ttcccatctg cacccttgcc 600
ccatccctcc cacacacagg accagacggc caccatgtca ggagactacg aggatgacct 660
ctgccggcgg gcactcatcc tggtctcgga cctctgtgcg cgggtccgag atgctgacac 720
caacgacagg tgccaggagt tcaatgaccg aatccgaggc tatccccggg gtccagatgc 780
agacatctcc gtgagcctgc tgtcggtcat cgtgacattc tgtggcattg tccttctggg 840
tgtctctctc ttcgtgtcct ggaagttgtg ctgggtgccc tggcgggaca agggaggctc 900
ggcagtgggc ggtggccccc tgcgcaaaga cctaggccct ggtgtcgggc tggcaggcct 960
ggtaggcgga ggcgggcacc acctggcggc tggcctgggt ggccatcctc tgctgggcgg 1020
cccacaccac catgcccatg ccgcccacca tccacccttt gctgagctgc tggagccagg 1080
cagcctgggg ggttctgaca cccctgagcc ctcctacttg gacatggact cgtatccaga 1140
ggctgcagca gcagcagtgg ccgctggggt caaaccgagc caaacatccc ctgagctgcc 1200
ctctgagggg ggagcaggct ctgggttgct cctgctgccc cccagtggtg ggggcttgcc 1260
cagtgcccag tcacatcagc aggtcacaag cctggcaccc actaccaggt acccagccct 1320
gccccgaccc ctcacccagc agactctgac ctcccagccg gaccccagca gtgaggagcg 1380
cccacctgcc ctgcccttac ccctgcctgg aggcgaggaa aaagccaaac tcattgggca 1440
gattaagcca gagctgtacc aggggactgg ccctggtggc cggcggagcg gtgggggccc 1500
aggctctgga gaggcaggca caggggcacc ctgtggccgt atcagcttcg ccctgcggta 1560
cctctatggc tcggaccagc tggtggtgag gatcctgcag gccctggacc tccctgccaa 1620
ggactccaac ggcttctcag acccctacgt caagatctac ctgctgcctg accgcaagaa 1680
aaagtttcag accaaggtgc acaggaagac cctgaacccc gtcttcaatg agacgtttca 1740
attctcggtg cccctggccg agctggccca acgcaaactg cacttcagcg tctatgactt 1800
tgaccgcttc tcgcggcacg acctcatcgg ccaggtggtg ctggacaacc tcctggagct 1860
ggccgagcag ccccctgacc gcccgctctg gagggacatc gtggagggcg gctcggaaaa 1920
agcagatctt ggggagctca acttctcact ctgctacctc cccacggccg ggcgcctcac 1980
cgtgaccatc atcaaagcct ctaacctcaa agcgatggac ctcactggct tctcagaccc 2040
ctacgtgaag gcctccctga tcagcgaggg gcggcgtctg aagaagcgga aaacctccat 2100
caagaagaac acgctgaacc ccacctataa tgaggcgctg gtgttcgacg tggcccccga 2160
gagcgtggag aacgtggggc tcagcatcgc cgtggtggac tacgactgca tcgggcacaa 2220
cgaggtgatc ggcgtgtgcc gtgtgggccc cgacgctgcc gacccgcacg gccgcgagca 2280
ctgggcagag atgctggcca atccccgcaa gcccgtggag cactggcatc agctagtgga 2340
ggaaaagact gtgaccagct tcacaaaagg cagcaaagga ctatcagaga aagagaactc 2400
cgagtgaggg gtctggccta ggcccgggat cggaccaggc tccctcagga ccccatcctt 2460
tcctgcccgg accgtgaatt catctccttg aagccataac gtccgagctg ctggtgcggg 2520
gcagccctgg ccctaggctt cctaaccctg gaagcgagag gatgagagga ggccggccca 2580
gctccttctt tcagggtggg ggtcattcag cctccactgt gtctgtcttt tcttccctgg 2640
ggctccccct cgaggcgagg ggccatgcat gtctggggga cccctgcccc ccaaaaccct 2700
ctgtctgtct ctgtctcttt gctgtttgtc caagactcag tgtcccgacc cttgttctcg 2760
ccgtgaatgt caatgggcca atcctctctg tcctttcaga cacacacaca cctgtgtcca 2820
ccccttctgt tcgccacacc ctgcgtctgg ccggtccccc cactgctgct gctatcaacg 2880
ccagaataaa cacactctgt gggtctcact ccaaaaaaaa 2920
<210> 75
<211> 1280
<212> DNA
<213> 人类
<400> 75
ccctttcgct gcggcctttc cccaacccgg acccggcact tctcgggttc cgcgactgcc 60
gatcgccccg gcgcggcacc gctccctcag gagtcgccta ggccgcgcag tctcccgact 120
tctcgtcagg ctttcgcgcc ggcgctccag caatcactgg ctggagaagg tgggcgttcc 180
ggctcgagag gaccctgccg cggctccgga agagcctcgt cctgggcggc ggtggtgcgg 240
cggtcgccgt tatggccact gggctgggcg gctgaccgcg ggctaggaaa gggcccaggg 300
cccgaatctc ggtggccgct gctccagcgc ggcctgcgcc atggcctcct ccgccgcctc 360
ctcggagcat ttcgagaagc tgcacgagat cttccgcggc ctccatgaag acctacaagg 420
ggtgcccgag cggctgctgg ggacggcggg gaccgaagaa aagaagaaat tgatcaggga 480
ttttgatgaa aagcaacagg aagcaaatga aacgctggca gagatggagg aggagctacg 540
ttatgcaccc ctgtctttcc gaaaccccat gatgtctaag cttcgaaact accggaagga 600
ccttgctaaa ctccatcggg aggtgagaag cacacctttg acagccacac ctggaggccg 660
aggagacatg aaatatggca tatatgctgt agagaatgag catatgaatc ggctacagtc 720
tcaaagggca atgcttctgc agggcactga aagcctgaac cgggccaccc aaagtattga 780
acgttctcat cggattgcca cagagactga ccagattggc tcagaaatca tagaagagct 840
gggggaacaa cgagaccagt tagaacgtac caagagtaga ctggtaaaca caagtgaaaa 900
cttgagcaaa agtcggaaga ttctccgttc aatgtccaga aaagtgacaa ccaacaagct 960
gctgctttcc attatcatct tactggagct cgccatcctg ggaggcctgg tttactacaa 1020
attctttcgc agccattgaa cttctatagg gaagggtttg tggaccagaa ctttgacctt 1080
gtgaatgcat gatgttaggg atgtggatag aataagcata ttgctgctgt gggctgacag 1140
ttcaaggatg cactgtatag ccaggctgtg ggaggaggga ggaaagatga aaaaccactt 1200
aaatgtgaag gaacaacagc aacaagacca gtatgatata ccaaggtaat aaatgctgtt 1260
tatgacttct ttaaaaaaaa 1280
<210> 76
<211> 970
<212> DNA
<213> 人类
<400> 76
ctgattatag ttctgaggcc ctagctactc actttgcaaa ctccaggctc cggtcgcgca 60
cgggacgaac tgcggggagt gagccgcgcg ggccgccgta gtcagctgct aagagcagga 120
agagtccgag cggcgggcgg agtctgcagg atggcaccgg acccctggtt ctccacatac 180
gattctactt gtcaaattgc ccaagaaatt gctgagaaaa ttcaacaacg aaatcaatat 240
gaacgaaaag gtgaaaaggc accaaagctt accgtgacaa tcagagcttt gttgcagaac 300
ctgaaggaaa agatcgccct tttgaaggac ttattgctaa gagctgtgtc aacacatcag 360
ataacacagc ttgaagggga ccgaagacag aacctcttgg atgatcttgt aactcgagag 420
agactacttc tggcatcctt taagaatgag ggtgccgaac cagatctaat caggtccagc 480
ctgatgagtg aagaggctaa gcgaggagca cccaaccctt ggctctttga ggagccagag 540
gagaccagag gcttgggttt tgatgaaatc cggcaacagc agcagaaaat tatccaagaa 600
caggatgcag gccttgatgc cctttcctct atcataagtc gccaaaaaca aatggggcag 660
gaaattggga atgaattgga tgaacaaaat gagataattg acgaccttgc caacctagtg 720
gagaacacag atgaaaaact tcgcaatgaa accaggcggg taaacatggt ggacagaaag 780
tcagcctctt gtgggatgat catggtgatt ttactgctgc ttgtggctat cgtggttgtt 840
gcagtctggc cgaccaactg atggcagtaa agagaccacc agcagtgaca cctggcaatg 900
acagatgcaa gcccaacacc cttttggtac gcaaaacctg ctctcaataa attcccccaa 960
agctctgaaa 970
<210> 77
<211> 1709
<212> DNA
<213> 人类
<400> 77
gacccggagc agcagcagag gcaggaggac taggaggagg aggaggagcc gtcgcaggat 60
gaaggatcgg actcaagagc tgcggagtgc gaaagacagt gatgatgaag aggaggtggt 120
ccacgtggat cgggaccact tcatggatga gttctttgaa caggtggaag agatccgggg 180
ctgcattgag aaactgtcgg aggatgtgga gcaggtgaaa aaacagcata gcgccatcct 240
ggccgcaccc aacccagatg agaagaccaa acaggagctg gaggatctca ctgcagacat 300
caagaagacg gccaacaagg ttcggtccaa attgaaagcg atcgagcaaa gcattgaaca 360
ggaggagggg ctgaaccgtt cctccgcgga cctgcgcatc cgcaagaccc agcactccac 420
actgtcccgg aagttcgtgg aggtaatgac cgaatataac gcgacccagt ccaagtaccg 480
ggaccgctgc aaggaccgga tccagcggca actggagatc actggaagga ccaccaccaa 540
cgaagaactg gaagacatgc tggagagcgg gaagctggcc atcttcacag atgacatcaa 600
aatggactca cagatgacga agcaggcgct gaatgagatt gagacgaggc acaatgagat 660
catcaagctg gagaccagca tccgcgagct gcacgatatg tttgtggaca tggccatgct 720
cgtagagagc cagggagaga tgattgaccg catcgagtac aacgtggaac attctgtgga 780
ctacgtggag cgagctgtgt ctgacaccaa gaaagcagtg aaatatcaga gcaaggcccg 840
gaggaagaaa atcatgatca tcatttgctg tgtggtgctg ggggtggtct tggcgtcatc 900
cattgggggg acgctgggct tgtaggcccc ccccaccctt ctctctccca gacccttccc 960
ccaccacatc gggagcaata cccccaccac ccctttcact ccatcccctg ctccaggctc 1020
actcccaaaa cagacccagg cagccccacc cctcctccac ccccacggca gaccctggtg 1080
tccctggacc tcaccgggcc atggaccccc ccccgtcccc gcacgtagat cgcagcaggc 1140
gtgattacac atgcacacca acatgcatgc cgccggcaca tgctcgagac gtgtggacac 1200
cccagcgtgc gtgtgcgtgt gatgtgtgtg atgcaccaga gcaccccctc cacccccacc 1260
ttgggtgtgt gtgcgtggtc tgagcttccc ccttcaccgg ggctgttgtg tagactgcag 1320
ccaagtgtaa cacagcagtc catcacgccc tctctgtcct ctgtgaacag tgtgtgtgcg 1380
tgcgtgagac cacagatctg tggacacacc atttgtgtac gtggaatttt gtgtttcagt 1440
gtttgaacct aatgcaacag caacaaagcc actgatacct gagccctttg tgtctgctac 1500
aaaccaggca ggtggtgtgt gtggactcac actcacattc tcagaggatc cagggaggcc 1560
caggtacaca caggccatgg cagacacccc atgtctttgt taccccaggg gctgtggcat 1620
gtcccaggag ggtgtgcatg tgtgtgtgtg tgtgtgtgtg tgtgtccagg atgtgcctga 1680
agtattgata ggtcttctca gatagagcc 1709
<210> 78
<211> 850
<212> DNA
<213> 人类
<400> 78
gggcgataat ggcggcgtcg aggctggagc taaacctggt gcggctgcta tcccgctgcg 60
aggcgatggc agcggagaaa cgggacccgg acgagtggcg cctggagaag tacgtgggag 120
ccctagagga catgttgcag gccctgaagg tccacgcgag caaaccggcc tctgaggtga 180
tcaatgaata ttcctggaag gtggattttc tgaaggggat gctgcaagcc gagaagctga 240
cctcctcctc agagaaagca ctggccaacc agttcctggc ccctggccgt gtgccaacca 300
cagccagaga gcgagtgccc gccacaaaga cggtgcatct gcagtcacgg gcgcggtaca 360
ccagcgagat gcggagtgag ctactaggca cggactctgc agagcctgag atggacgtaa 420
ggaagagaac tggagtggca gggtcccagc cagtgagtga gaagcagtcg gcagctgagc 480
tagacctcgt cctgcagcga catcagaacc tccaggaaaa gctggcggaa gagatgctag 540
gactggcccg gagcctcaag accaataccc tggccgccca gagtgtcatc aagaaggaca 600
accagaccct gtcacactca ctgaaaatgg cggaccagaa cctggagaaa ctgaagacgg 660
agtcagagcg tctggagcag cacacgcaga agtcagtcaa ctggctgctc tgggccatgc 720
tcattatcgt ctgcttcatc ttcattagca tgatcctctt cattcgaatc atgcctaaac 780
tcaaataaag acccccgccc acctaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 840
aaaagaaaaa 850
<210> 79
<211> 1410
<212> DNA
<213> 人类
<400> 79
gatcggactc aagagctgcg gagtgcgaaa gacagtgatg atgaagagga ggtggtccac 60
gtggatcggg accacttcat ggatgagttc tttgaacagg tggaagagat ccggggctgc 120
attgagaaac tgtcggagga tgtggagcag gtgaaaaaac agcatagcgc catcctggcc 180
gcacccaacc cagatgagaa gaccaaacag gagctggagg atctcactgc agacatcaag 240
aagacggcca acaaggttcg gtccaaattg aaagcgatcg agcaaagcat tgaacaggag 300
gaggggctga accgttcctc cgcggacctg cgcatccgca agacccagca ctccacactg 360
tcccggaagt tcgtggaggt aatgaccgaa tataacgcga cccagtccaa gtaccgggac 420
cgctgcaagg accggatcca gcggcaactg gagatcactg gaaggaccac caccaacgaa 480
gaactggaag acatgctgga gagcgggaag ctggccatct tcacagatga catcaaaatg 540
gactcacaga tgacgaagca ggcgctgaat gagattgaga cgaggcacaa tgagatcatc 600
aagctggaga ccagcatccg cgagctgcac gatatgtttg tggacatggc catgctcgta 660
gagagccagg gagagatgat tgaccgcatc gagtacaacg tggaacattc tgtggactac 720
gtggagcgag ctgtgtctga caccaagaaa gcagtgaaat atcagagcaa ggcccggagg 780
aagaaaatca tgatcatcat ttgctgtgtg gtgctggggg tggtcttggc gtcgtccatt 840
ggggggacgc tgggcttgta ggcccccccc acccttctct ctcccagacc cttcccccac 900
cacatcggga gcaatacccc caccacccct ttcactccat cccctgctcc aggctcactc 960
ccaaaacaga cccaggcagc cccacccctc ctccaccccc acggcagacc ctggtgtccc 1020
tggacctcac cgggccatgg accccccccc gtccccgcac gtagatcgca gcaggcgtga 1080
ttacacatgc acaccaacat gcatgccgcc ggcacatgct cgagacgtgt ggacacccca 1140
gcgtgcgtgt gcgtgtgatg tgtgtgatgc accagagcac cccctccacc cccaccttgg 1200
gtgtgtgtgc gtggtctgag cttccccctt caccggggct gttgtgtaga ctgcagccaa 1260
gtgtaacaca gcagtccatc acgccctctc tgtcctctgt gaacagtgtg tgtgcgtgcg 1320
tgagaccaca gatctgtgga cacaccattt gtgtacgtgg aattttgtgt ttcagtgttt 1380
gaacctaatg caacagcaac aaagccactg 1410
<210> 80
<211> 1730
<212> DNA
<213> 人类
<400> 80
ccgttctgct ctcgggggca ccttccgggg ttcctaagcc gcggggcccc tcgctgcccc 60
tcgaggccct ttccctgacc taggctttgg cctgggctac tcgttccgga gccgccatgt 120
cgtccgactt cgaaggttac gagcaggact tcgcggtgct cactgcagag atcaccagca 180
agattgcgag ggtcccacga ctcccgcctg atgaaaagaa acagatggtt gcaaatgtgg 240
agaaacagct tgaagaagcg aaagaactgc ttgaacagat ggatttggaa gtccgagaga 300
taccacccca aagtcgaggg atgtacagca acagaatgag aagctacaaa caagaaatgg 360
gaaaactcga aacagatttt aaaaggtcac ggatcgccta cagtgacgaa gtacggaatg 420
agctcctggg ggatgatggg aattcctcag agaaccagag ggcacatctg ctcgataaca 480
cagagaggct ggaaaggtca tctcggagac tagaggctgg ataccaaata gcagtggaaa 540
ccgagcaaat tggtcaggag atgttggaaa accttagtca tgacagagaa aagatacagc 600
gagcacgtga aagacttcgg gaaacagatg ctaatttggg aaaaagctcc aggattctga 660
cagggatgtt gcgaaggggt tgttctgtga aaaaacaatg taacctgtct ctggccccaa 720
aggcttgaac cagaaccagc cagtggaaat tactcaaaca cgtattgtgc cttcaatgag 780
aagccttctc actgaaagag ctgccctgga cggaaaatga gtagtgagat gatgctggtg 840
gaagtattta tagatgcgca gtgcatgagt acttggcaag gatgctatca aaggggaaac 900
tgacatcaaa tgtgctgtgg ttctgggtga tttatctggt cccttcccat cccagagctt 960
tatgattctg taataatcaa gggagaaacc cattacatag tggacaattt tttttctttt 1020
tttttctttt tctttttttt tttgagacag agtcttgccc tgtcgcctgg ctggagtgga 1080
gtggcacaat cttggctcac tgcaacctcc acctcccagg tccaagcgat tctcttgcct 1140
cagcctccca agtagctggg actacaggca cacaccacca cgcccagcta atttttgtat 1200
ttcttttttt tttttttgta gagatggagt ttcaccatgt tggccaggat ggtctcgatc 1260
tcttaacctt gtgagccacc gtgcccaacc ctaacaatta tttttaaaag gaggaattta 1320
aatgagctgt ggattattca ttttgtccca taagaagata attaaaaaat gacaaaaatg 1380
aactgaacaa aaaagttcta acaaaataat aaggctgaat ttttaaagtc tcttccgcat 1440
cttctgttcc ctgggatgcc ttagacgggg tgtgcagtat tttaggtaca tcgtgagcaa 1500
ggagcctgca ttcccagggg gcggcaggga cagcatgtaa ggtcttagtc cagctctgtg 1560
atctgaaggc aaagcctcta tgtgtgaaac acaggggtac ctcaaaaata gaacaagagc 1620
actccatcca tgtgcggatg actgtcaagg tcactgagac ctacagtgat ctggaaaatt 1680
aaagctctct ggccgccttt cctctcagga catacttctg gagatcaaaa 1730
<210> 81
<211> 1830
<212> DNA
<213> 人类
<400> 81
gcccaccgac cggcctcgag cgccccggcg ggaggttttt ctatatgagt ggagaagaca 60
gctgttacca gggaggtcat acaacatttt tttaggatgt ctgaagatga agaaaaagtg 120
aaattacgcc gtcttgaacc agctatccag aaattcatta agatagtaat cccaacagac 180
ctggaaaggt taagaaagca ccagataaat attgagaagt atcaaaggtg cggaatctgg 240
gacaagttgc atgaagagca tatcaatgca ggacgtacag ttcagcaact ccgatccaat 300
atccgagaaa ttgagaaact ttgtttgaaa gtccgaaagg atgacctagt acttctgaag 360
agaatgatag atcctgttaa agaagaagca tcagcagcaa cagcagaatt tctccaactc 420
catttggaat ctgtagaaga acttaagaag caatttaatg atgaagaaac tttgctacag 480
cctcctttga ccagatccat gactgttggt ggagcatttc atactactga agctgaagct 540
agttctcaga gtttgactca gatatatgcc ttacctgaaa ttcctcaaga tcaaaatgct 600
gcagaatcgt gggaaacctt agaagcggac ttaattgaac ttagccaact ggtcactgac 660
ttctctctcc tagtgaattc tcagcaggag aagattgaca gcattgcaga ccatgtcaac 720
agtgctgctg tgaatgttga agagggaacc aaaaacttag ggaaggctgc aaaatacaag 780
ctggcagctc tgcctgtggc aggtgcactc atcgggggaa tggtaggggg tcctattggc 840
ctccttgcag gcttcaaagt ggcaggaatt gcagctgcac ttggtggtgg ggtgttgggc 900
ttcacaggtg gaaaattgat acaaagaaag aaacagaaaa tgatggagaa gctcacttcc 960
agctgtccag atcttcccag ccaaactgac aagaaatgca gttaaaaacc aaatttcagt 1020
attattggtg ccaacatgtc tatcctgagg acctttgctg ctgttggaca ctccgtcacc 1080
ttttggaaca caagtatatc aagatagtgg ctactgatgt tcaagtggga ttgaagtgtg 1140
ataaatggat atattttgtt gtttgctggg gtgttcatgg agatgttaag agattgaggc 1200
cctgggctga gggtatataa tgtatgtcag gtaaagtttg aagactgcca aggagcagat 1260
tttctccctg gaaatgtgaa aactgaacct ataactctga taaggacttg agatgtgtag 1320
aaacgttggg ttatggaaga ctagtttctt ccataaccct gaattggaga ccttaatgct 1380
aagtgtagat tattgaggtt tgttagtgag gaaaagaata agagttcaga agcctttgtt 1440
atcagatagc gaaatcaggg cctagtgagg agcacaggtc gactacataa tggagtccat 1500
tggcgaaccc tattgcaatt tggtccaact atatcttctg gtgaaggaaa ttaatgatgt 1560
aagaaaatgc aagaggctca acttctcttc caaaaatctt ctggcttctg aactcttcct 1620
ctgcctctct ttaaataaat aacacagaat ttcaagtggt aggagactta ttaagccagt 1680
caccaagctt ggtctgtcag cctgtcttct aacacctcaa agatcttgtg ccctgtgctg 1740
tccctccctt gtaattatga aaagttcttt ggtttctggg gtgaattcta cccatgtata 1800
atgaggaatt ctctcataac cttaaaaaaa 1830
<210> 82
<211> 3330
<212> DNA
<213> 人类
<400> 82
gcggagcgcg cggggcgcgg ttgccgtggc agcgccggct ccagggaggg ctgctggcgc 60
cgggccggga ccgcggggcc tgaggcggag accggagagc ccgcggcccg gccggaggca 120
gctcgggaca ggcttgagcg gcggggcgcg ctgcccggcc ggcggggatg cgggaccggc 180
tgccagacct gacggcgtgt aggaagaatg atgatggaga cacagttgtt gtggttgaga 240
aagatcattt catggatgat ttcttccatc aggtggagga gattagaaac agtattgata 300
aaataactca atatgttgaa gaagtaaaga aaaaccacag catcattctt tctgcaccaa 360
acccggaagg aaaaataaaa gaagagcttg aagatctgaa caaagaaatc aagaaaactg 420
cgaataaaat tcgagccaag ttaaaggcta ttgaacaaag ttttgatcag gatgagagtg 480
ggaaccggac ttcagtggat cttcggatac gaagaaccca gcattcggtg ctgtctcgga 540
agtttgtgga agccatggcg gagtacaatg aggcacagac tctgtttcgg gagcggagca 600
aaggccgcat ccagcgccag ctggagataa ctgggagaac caccacagac gacgagctag 660
aagagatgct ggagagcggg aagccatcca tcttcacttc cgacattata tcagattcac 720
aaattactag acaagctctc aatgaaatcg agtcacgtca caaggacatc atgaagctgg 780
agaccagcat ccgagagttg catgagatgt tcatggacat ggctatgttt gtggagactc 840
agggtgaaat gatcaacaac atagaaagaa atgttatgaa tgccacagac tatgtagaac 900
acgctaaaga agaaacaaaa aaagctatca aatatcagag caaggcaaga aggaaattga 960
tgttcattat tatttgtgta attgttttgc ttgtgatcct tggaattatc ctagcaacaa 1020
cattgtcata gcaaccatat cccaagagcc atttatcctt gagactcaga ccacatctgc 1080
aaccaaatca gcatcctgtc atttcgtgaa tgaatctcag acgctgtaac ccggcatcga 1140
gtgctgacct tgtaatgtat gagttcacgg aagaagcaca accgaacgtc ttgttcagtg 1200
acagcgccgt aagcacagtg ggtgtgatgc gtgaccctga atgacacact acagaatgtg 1260
agcagtgtga gacttctctc actggccttg aaataagaaa atattgaaca ttttaatatt 1320
aaaaatattt cagtgttaac aaatgtgcat gaagtttaat taggaaggaa tgctttatgt 1380
tatgaaggct tttttttttt ttttttgaga cggagtctcg ctttgtcatc caggctggag 1440
tgcagtggtg cgatctcagc tcactgcaac ctcagcctcc cgggttcaag caattctcct 1500
gcctcagcct cccgagtagc tgggattaca ggcatgggcc accacaccca gctaattttt 1560
tgtgttttct ttttagtaga gacggggttt taccatgctg gccaggctgg cctcaaactc 1620
ctgaccttgt gatccaccca cctcagcctc ccaaagtgct gggattacag gcgtgagtca 1680
ccgggcaggc tgttctgaag cttttagatc tcaggtctaa ggcttccttt ccctccctct 1740
cccagctagt ttgtgctaat taagagacct tttatactgt tttattgcct gtttgaagaa 1800
ataattttta tcacgttttt gtaagatatc tataatttta aatgtttata aattgtttaa 1860
tttattagca tcttaatgta ccccattttt atatactgaa tgtggccttt tgagtgaaat 1920
aggaagcttc atggtgttgg agccaccttt gtacagttgt ttaaagtttc ccattgtcac 1980
ggaaaacatt ggctgcaaag cccctcaaag ccctcaagtg ccttctgtga gtttaaatgt 2040
gctggtgccc tccagaaaag cctcggcctc agctccgttt ccgcctgttc cctcccccag 2100
gataatgaat ggttactgca ctgtaaagac cgtggtctct tttcactaaa taggagattc 2160
gagtttccca gtttacatga atgaagtctg aatttaagac ggtgatgaaa ctgaggttca 2220
gtactctcgg gactcgagga aattattcct gagacatgga gtaattctta caaatttaaa 2280
ctattgtaca gatccacata catgttgtta agtacctaat gttttgctga acttttaaaa 2340
gttaatttcc aaaatgtata gggattcatg ataattaaac ctttttattg ctcatttttt 2400
tagtagaaga atatcactta tttttagact tgtaaaatgt atgaactggt gagcggacat 2460
ctgttaagag agtcactagt cagaatgtta aaggagtgca tgcaggatgc cccaaatgtc 2520
gtgaactctt gttactcctg tatgtagtag tgtaagcatg tgacttttaa caccatttgg 2580
tttgaaacta atgtagagat gcctgattcc aaacaggtgt ggagaatatt gaacggctca 2640
gaagccgcgt cccttactta acacaattcc gaatctccct catccatgat gcgtccattg 2700
gatcactcgc tggtggtcac tgtgtggcag ttactagggg aattctgcct ctgactgttc 2760
tttttctttt ggtctttaaa caccctgtcg tgggatgtgc tcactgattt gtggctatgt 2820
tgaaggtatc acttgtcttg agggttttca atatttcagg atcatgctgg tggcaaaagg 2880
actccacgcc tctgtggaat catgtccaca gggggacctg cctcccgtga tgtcccacct 2940
ttccttcaag gtctgtcata tgagtcctcc ccttttacaa cacttattat ggtatttttc 3000
aagttattct tcttagattt gcagtaccta ctgaaatttg tgtttttata gttgaagtta 3060
ggaaaatgct atttgatttg tatttagata tttaagtcac ttgtccaatg atgtgtatgt 3120
ctaagcctca tgtaccgatt tgaagtcaga cttaaaaatg tatttacaga ttcacttgag 3180
actttttaat cggttcttca aatatttcat gtttacatta aaaatttcca gagaagcata 3240
aaagtattca ctttcctgcc ttgtcatttc tggaaagatt ttggggagat attttattgc 3300
atattaatta ataaattgtt ctactaggaa 3330
<210> 83
<211> 1390
<212> DNA
<213> 人类
<400> 83
gggaagaaaa gggaattcca acctgtggaa ccttgggggg tccccggggt cggcgccttc 60
ccattgactg tgggcggtgc aagggacgga gcctctggcg gctcgtgggg gtgttggggt 120
ccgcaggggg agggagggga gtgtcagagt gtgagcgggg tacgggaatt ccaaatttga 180
gggcctcccg gctctggcgc cggggaggga gagctcaggc cgccatgcgg gacaggaccc 240
acgagctgag acagggggat gacagctcgg acgaagagga caaggagcgg gtcgcgctgg 300
tggtgcaccc gggcacggca cggctgggga gcccggacga ggagttcttc cacaaggtcc 360
ggacaattcg gcagactatt gtcaaactgg ggaataaagt ccaggagttg gagaaacagc 420
aggtcaccat cctggccacg ccccttcccg aggagagcat gaagcaggag ctgcagaacc 480
tgcgcgatga gatcaaacag ctggggaggg agatccgcct gcagctgaag gccatagagc 540
cccagaagga ggaagctgat gagaactata actccgtcaa cacaagaatg agaaaaaccc 600
agcatggggt cctgtcccag caattcgtgg agctcatcaa caagtgcaat tcaatgcagt 660
ccgaataccg ggagaagaac gtggagcgga ttcggaggca gctgaagatc accaatgctg 720
ggatggtgtc tgatgaggag ttggagcaga tgctggacag tgggcaaagc gaggtgtttg 780
tgtccaatat cctgaaggac acgcaggtga ctcgacaggc cttaaatgag atctcggccc 840
ggcacagtga gatccagcag cttgaacgca gtattcgtga gctgcacgac atattcactt 900
ttctggctac cgaagtggag atgcaggggg agatgatcaa tcggattgag aagaacatcc 960
tgagctcagc ggactacgtg gaacgtgggc aggagcacgt caagacggcc ctggagaacc 1020
agaagaaggc gaggaagaag aaagtcttga ttgccatctg tgtgtccatc accgtcgtcc 1080
tcctagcagt catcattggc gtcacagtgg ttggataatg tcgcacattg ttggcactag 1140
gagcaccagg aacccagggc ctggccttct ctcccagcag cctggggggc agggcagagc 1200
ctccagtcgg accccttcct cacactggcc cctatgcaga agggcagaca gttcttctgg 1260
ggttggcagc tgctcattca tgatggcctc ctccttcagg cctcaatgcc tgggggaggc 1320
ctgcactgtc ctgattggcc gggacacacg gttttgtaaa aaattaaaaa acaaaaaaag 1380
agcataaaaa 1390
<210> 84
<211> 2140
<212> DNA
<213> 人类
<400> 84
gtgacgcgcc ctcctcgcgg tgcccttcag ccgccgccgc agctcaccgg gcgccacatg 60
gacccagccg gcccgagcgc gccccgccgc tgaccgcccg cgccccggga aggaagaaca 120
ctcgctcccg gccatacttg cgtgtgagtt ctgacccctg gaggagccac tgtggaagca 180
gagcaatcgc catggagttt gtgatgaagc aggctctagg aggggccacc aaggacatgg 240
ggaagatgct ggggggtgac gaggagaagg acccagacgc cgccaagaag gaggaggagc 300
ggcaggaggc gctgcgccag gcggaggagg agcgcaaggc caagtacgcc aagatggagg 360
cggagcgcga ggccgtgcgc cagggcatcc gagacaagta cggcatcaag aagaaggagg 420
agcgcgaggc cgaggcccag gccgccatgg aggccaactc cgaggggagc ttgacgcggc 480
ccaagaaggc catcccgccg ggctgcgggg acgaggtgga ggaggaggac gagagcatcc 540
tggacaccgt catcaagtac ctgcccgggc cgctgcagga catgctcaag aagtagcccc 600
gcgcgggaca gcggccccgc ggagcccccg cccctccccc tacagatcct ccgcggaggc 660
ccctgaggga cgagcagagc gcagccccca cgccgatata agccatagcc ccaggcccgc 720
cctgcccgcg cccgccgcct ccctcacccg gcaaggggcg cgcgccccca ggaccccccc 780
agtccgcccc gtgctcctct gcccgcgggt ggctggagcc ccatcgcctg ggacgcccct 840
ttctcttgct gtttaccgcc cacccagcag cgcccgaggc cagggccgcc gaagggcagc 900
cccgcgacca cccctgtgcg cgcgttcgcg gcggtgggcg cctgtcgggc ccgcactcag 960
gagcacagcc atagcagacg ggggggtgcg ggcggggcga gggcggcggg gcctgggtcc 1020
ccctcctgca cgcggactcc ggggttcgga tcgctccgcc gtgagtattt gcgtccgcac 1080
gcggccgctc tccgcccccc ggcctggccc cctcgcgccc ctgtccatcc gtctctgtcc 1140
gcgtcctttc ctctcctctc tggaaggttt tgcttcttac gaacgccacg gccgtgttca 1200
cttctaaact aaagaaaaca aagcaatagg tttgggggac gcccagcccc cacccccgtc 1260
accccgctct tcccgagtcc tcgccccccg cccggcctcc tagcctctcc gcccacgcgg 1320
ctgctgcttc tccctgggga ggacccctgc cctcggccat tgaacactgc accctccaca 1380
ggagccgcag aggcccgagg caccggacgc tggagaccct gcgcccctgc ccagcacctc 1440
ctccgtgggc agctcctcgg gtggggcctg cggggttccc tgcgcgcagc cggcgcgtgt 1500
gtggcctaat ccacctggtg gccctgcggg gcggcatccg agcccctgtt tctcctccat 1560
tcatgtttaa tttgcatcac aatttgttga atctcaggta aatgaggtct ttgcatttaa 1620
tgagttttat cttgacaggc gccgcctcgc ccccgggccc tttcgtccac atcaaaaatg 1680
catcaagtct ccacgtgttt cgggccaggg cgtggcttgg cattgacctt catgacctta 1740
catagcttta gagaagccat aacgttagac tgcaatacta acgaccgacg cccctccggg 1800
cagagacaac cgcgcccctc tgcgccccag cgacgcggcc cgcggggacg tcgctgtccg 1860
tcctgctcgc cctgtgccct ctcactgact tctcccgggt cgtgtctttt aaaaactcct 1920
gttttcacac cttacaaagc cagctctgag cagacagggc gtcctctcgt agaacctgcg 1980
caccccgttc ccagcgcatg gcgccccggg ccgcgagctt agcttagacc gtggtgtcct 2040
ctgtccgtct gtcctgcgcc tgcgcctcct cctgcatgtc ggggcccctg cgtgtgttct 2100
ctccggatgg aatcacagcc aataaacacc agtgatttca 2140
<210> 85
<211> 2940
<212> DNA
<213> 人类
<400> 85
gcgcggcgga ggctcccgtg gcctcggacg ctcctcctag ctagcggccg ccgcccgccg 60
ccgcctgcgc ctccagctcc ttcgccccgg cgggcccggc cgccgcttcc ggcagctcac 120
ctgggaagcg ctcacctggg acgcgctcac ctgggacgcg ctacctgcct ccgggcgcct 180
gggcttcagg atgaaggacc gtctggagca gctgaaggcc aagcagctga cacaggatga 240
tgatactgat gcggttgaga ttgctatcga caacacggct tttatggacg agttcttttc 300
tgagattgag gaaactcggc ttaacattga caagatctca gaacatgtag aggaggctaa 360
gaaactctac agtatcattc tctctgcacc gattccagag ccaaaaacca aggatgacct 420
agagcagctc acgactgaga ttaagaaaag ggccaacaac gtccggaaca aactgaagag 480
catggagaag catattgaag aagatgaggt caggtcatcg gcagaccttc ggattcggaa 540
atcccagcac tctgtccttt ctcggaagtt tgtggaggtg atgaccaaat acaatgaagc 600
tcaagtggac ttccgagaac gcagcaaagg gcgaatccag cggcagctcg aaattactgg 660
caaaaagaca accgatgagg agctggagga gatgttggag agtggcaacc cggccatctt 720
cacttctggg atcattgact cacagatttc caagcaagcc ctcagtgaga ttgagggacg 780
acacaaggac attgtgaggc tggagagcag catcaaggag cttcacgaca tgtttatgga 840
catcgccatg ctggtggaga atcagggtga gatgttagat aacatagagt tgaatgtcat 900
gcacacagtg gaccacgtgg agaaggcacg agatgaaacg aaaaaagctg tgaaatacca 960
gagtcaggcc cggaagaaat tgataattat cattgtgcta gtagttgtgt tgctgggcat 1020
tttagcattg attattggac tttccgttgg gctgaattaa gagtggccta agaggctgct 1080
gcactgaaat aaactgattt cactccagac tggtgtggcc acccttgtct tcagatgaga 1140
atggagtctg aatggccttc ctgagagcga gtgcgacccg ttcctttgtt tccttgcaac 1200
cacccttgga cctgactcag ctaacaatct agccctgggg gaatgtgatc tacctgatgc 1260
gaccctgagt tctccccaga gcctcctcct gccccaccag ctctcaagta ccttttctcc 1320
tggactgtgt ggacccaccc agctttcttc ctccctgttg tgtgtcagat tatgccttgc 1380
acttgggaaa gctcttgtga gactctccca aggtgctgta tttttctacc tcatggagta 1440
ttctcccaga aactgcaatg tattttttta ggggagtatc tttaacaaag cagaatgatt 1500
cttctaagtt tggcaacaag aaggcttgga tctgagtctt ctacctggca ggatgccaat 1560
cctgtttgtt gtccgtatgt cctgaaaaca tgagggactg gcagatgtca ttttggtcta 1620
aagagctgac ttgtttgaaa ttcagcctta aattaagctc ttagttgttc agcttggggg 1680
gcaactttga tttttctctg tgttgtagtc tctcatattt actcaaggag ggaccaggat 1740
gatacagtca tctgaggtta tgctttgcaa aaggctgacg gtatggaata tgtttccatg 1800
tctgagtctt agaaactggc tgctcattgt tagaaagtga tgctttgtga gactattgtc 1860
ttggggccaa aaataatcag ggattttaaa ttgggcaagg gacaaggtgc tagaatccta 1920
agctctggaa atatttcatg acactggtgt attcactcat gtgttccaga tgtattctaa 1980
ttgtgtatga aatgtatgta cacataagtg tgtgtgtctc aggaagtagg aaataaaaat 2040
ggaagctatt atgacctcaa aaaaaaaaag ccaactttga gctaggataa aaattgggta 2100
aaggacattt gcttacctgc aaatgaatca ctgtggaaat gtgatcttcc catatcatca 2160
agaaacttgt tttctggatg aatactggga gaataaaatg agaactctgg agtgagctaa 2220
attgatccca attaagtttt tctgcttagc agacagaagg tataattttt tgacaccctt 2280
tcccacctgg tgcctatgct aggcttgtcc tgagaacatc cctcagtaac ttgatattca 2340
catgacctac aggatgtccc atctgcaggg ctgagtcagt tggggaacac cagaggctac 2400
acagtagctc ttcctgctac tcggttaatg agcttggcag gttctttgtc tcactgaatt 2460
cttatcatgg aaacagcagc agcagccgct aggaaatctt caagtgtagt gtctgtgcta 2520
acccagtggt aaatccctta gatcccctgc tggtctctgg cagtctcctt gattttgggt 2580
accatgtata ttttccgctt tgactttaac gctttctagg atagggtaag cacccttaat 2640
tcaggcactg tccattagct tcctttgcaa aggctactta tggccggtca caatccagca 2700
ctcagacaga gccaaggcaa tatcctcttg cccatggcta tgatgtcaga cagtggatgg 2760
gctccagcaa caagagacaa aataactaaa ggcctttgct ctcctctgac attgaggcct 2820
ggggcttaca gtttggaata caacatgtga aggtttttgt tgttgtttgt attttttaga 2880
tgtaaacttg attattttat tgctaattta aaaataaaaa tgactttgta ttgattgtga 2940
<210> 86
<211> 2880
<212> DNA
<213> 人类
<400> 86
gtcgacccac gcgtccggag cggtgtagag cgagcaggtc tcagctcctc gtcatgtcat 60
acggtccctt agacatgtac cggaacccgg ggccctcggg gccccagctc cgggacttca 120
gcagcatcat ccagacgtgc agcggcaaca tccagcggat cagccaagcc actgctcaga 180
taaagaattt gatgagccag ctaggaacta agcaggactc aagcaagcta caggaaaatc 240
tgcaacagtt acaacactcc acaaatcagc tcgccaagga aacaaatgaa ttgctgaaag 300
aattagggtc cttgcccctt cccttatcta cttcagaaca gcgccagcag agacttcaga 360
aggaacgcct catgaatgac ttctctgcag ccttaaacaa tttccaggct gtgcagagaa 420
gggtatctga aaaggaaaag gagagtattg ccagagcaag agctggatct cgtctttctg 480
cagaagagag gcaaagagag gagcagctgg tctcatttga cagccatgag gagtggaacc 540
agatgcagag ccaggaggat gaggtggcca tcactgagca ggatttggaa cttattaaag 600
aaagagaaac ggcaattcgg cagctggagg ctgacatttt ggatgtcaat cagatattta 660
aagatttggc catgatgatc catgaccagg gtgatctgat tgatagcata gaagccaatg 720
tggaaagctc agaggtgcac gtcgaaagag ccactgaaca gttacagcga gctgcttact 780
atcagaaaaa atctcgcaag aagatgtgta tcctggtgct tgtcctgtca gtgattattc 840
taatcttggg acttattatc tggctagttt ataaaacgaa gtgattgcct ccgatcgttc 900
tcccgctgag ctgttttcaa gggcaagtgc ttgttgaagt cttgccagaa caaactgatc 960
acaagaagac agcatatatc agaacgtcct gtaatcattt agttagaaac taactactaa 1020
ctagtctttg gaattcgtga cctatggaga cagtaattat caatttattg attctattga 1080
tttctcaaat taggaattaa cttatgtgga ttttgcttcc tcttgtattc tgattgccct 1140
tcatcccaag tgtttactga aaattccatt ctagatattc ttgttttgac aaatgacact 1200
acagtctcgt aatattgtct tttatgtata tacaaaattt acctttttac tagcatctga 1260
gatagagtta ctttctggta cccagtatat tggagtctgt cagaaactct ataataggcc 1320
accagttttt attatttaac atttttattt gaatttctaa gaagcctatt ctctatctat 1380
tttgaaagat tttggcacta tatttaattg gaaggtaaaa tattgtacat gtgatccaga 1440
gtaaatgaga agtctctatc tgagctggtc agttactgga gtacatgtta ctaatctggg 1500
tttaaagttt acttcattat ctgctagtgt catccacagc agttcatcct catccacact 1560
aagccatcct gttagctttt aaaggaagtt aatttaatta acattaatat actctatggg 1620
ctccctctcc cacctgtctg catagaaagg cagaattaga catagcatgc tttggaaaag 1680
caaataggaa ttgttgggaa tgatttaatc ttgttgttgt tgttgttgtt gttcacttgt 1740
ggttctacat tcctggtgaa tgatgaatgt tgctgtcaaa gggctgcccc ctaccttata 1800
agggttgctg ggcatttgaa ggcaggaaga tttttaaaga tagattgagg ttggtttaaa 1860
attattcctg taaaccaaca ataaagcaaa gaagaggttc atttttgtaa ataacactgg 1920
tttcaaatag tgatgttaga cttaacctaa tttataaaca agagattaat atctccatgc 1980
atagttttag acaaaaaaag atgtttcaat aaaattactg tcttgtaata taaatgttgt 2040
ccacttccct tttccacagg cctagaacag ttaaagggaa cataatttgt ttaggctccc 2100
acataaatgt gaatctggcc aacaactttg gttcatcctt tagtgaatta gaggatttgg 2160
ctaccctgag tatatttata ttcatttctt ctgttctcct tctgttatta tacttaatct 2220
tctaaactaa actaatgtga acagtaggga agcaagggcc caaatgcata agtttctttg 2280
cactgttgca cttacttaat acaaataaat gttttttaaa gcttttgtag tatgttttta 2340
tgagttaaca tcctaatgtg gtaggtatta ggtaatgtgc tgtcatgaga aaaattgaga 2400
cttccaagaa aactggacac caggtgaggg ttggtttgga gacggaatag gtgtagctgc 2460
ctttccttga aaaacagtgt gtagagatgg ctgagtgcaa tggctcacac ttgtaatccc 2520
aacactttgg aaggctgagg cgggaggatc agtatatcgg tacgtctgag cccaagagtt 2580
caagatcagc ctgggcagta tagcaagacc ccatctccat ttttttttta atgatttttt 2640
aattaaaaaa aagaacaaca ggatagagct gttggggtgg cacagtggcc caaagagcag 2700
cttcagagat aattccttgg ttctatgatc cctgtttaac tccaaattac agtcggactt 2760
ggatacatca tttgtaacat tgtaggaaag aaaaaagtct tggttgtgaa aaacgatttg 2820
catttgggta aaataaagtg accatgcttt tgttctgtaa aaaaaaaaaa aaaaaaaaaa 2880
<210> 87
<211> 2590
<212> DNA
<213> 人类
<400> 87
gacaaagatg gcggcaggga ccagcagtta ctgggaagat ctcaggaaac aggctcgaca 60
gctggaaaat gaacttgacc tgaaactagt ttccttcagc aaactatgta caagttacag 120
tcatagcagt acccgagatg gaagacgcga caggtatagt tctgatacaa cacccctttt 180
aaatggatca agccaagaca gaatgtttga gacaatggcg attgagattg aacaactttt 240
ggcaaggctt acaggggtaa atgataaaat ggcagaatat accaacagtg caggtgtccc 300
ctccttgaat gcagccctga tgcatacatt acagcggcat agagacatat tgcaggatta 360
tacacatgaa ttccataaaa ccaaagcaaa ctttatggca atacgggaaa gggagaatct 420
tatgggatca gtacgaaaag atattgagtc atataaaagt gggtctggag taaacaacag 480
aagaactgag ctatttttga aagaacatga ccaccttcga aactcagatc gtctgataga 540
agagacaata agcattgcta tggcaacaaa agaaaatatg acttcacaga gaggaatgtt 600
gaagtcaatt cacagcaaaa tgaacacttt ggccaatcgt tttcctgctg taaacagcct 660
gatccagagg atcaacctga ggaagcggcg ggactcgctc atcctagggg gtgttattgg 720
gatctgtacc atcctgttgc tgctgtatgc gttccattga tgggacatct tcagggactc 780
ttgacagcca ccgctttcac accctggtct ggaataagga aacatcggag ggagaagttg 840
actgtcttga taattagcct gaccagcagg atgaatgcaa gactgacagt gatggactct 900
gtgacatggt caggttgagc tgaagccaca gtttctctgt gctgtgtttt ctaacacatt 960
tttctgtttt taattaaaaa aaaaaaaaaa aggttttcag ttgcttttgt ctccctagga 1020
ggcaggtaaa ccaatcaaaa acagagtttt ctgtgtttcc atgatagtgt tgaagcctaa 1080
tgacaagcca ggtcttacag ctgggctctt cagaaaacca ggtttctaca tccaaagact 1140
gcttttcttt tagctgccag attggattgt gaataaaaat aattcttccc tctccctctc 1200
cctctcccca cggtctccct ctttccacgg tctccctctg atgccgagcc gaagctggac 1260
tgtactgctg ccatctcggc tcactgcaac ctccctgcct gattctcctg cctcagcctg 1320
ccgagtgcct gcaattgcag gcgagcgccg ccacgcctga ctgcctcggc ctcccgaggt 1380
gccgggattg cagacggagt ctcgttcact cagtgctcaa tggtgcccag gctggagtgc 1440
agtggcgtga tctcggctca ctacaacctc cacctcccag ccacctgcct tggcctccca 1500
aagtgccgag attgcagcct ctgcccggcc gccaccccgt ctggaaagtg aggagcgcct 1560
ctgcccggcc gccatcccat ctaggaagtg aggagcgcct cttcccagcc gccatcccat 1620
ctaggaagtg aggagcgtct ctgcccggcc gcccatcgtc tgagatgtgg ggagcgcctc 1680
tgccccgccg ccccgtctgg gatgtgagga gctcctctgc ccggccgcga ccccgtctgg 1740
gaggtgagga gcgtctctgt ctggccaccc cgtctgagaa gtgaggagac ctccgcccgg 1800
cagccgccct gtctgagaag tgaggagccc ctccgcccgg cagccacccc atctgggaag 1860
tgaggagcgt ctacgcccgg gcagctgccc cgtccgggag ggaggtgggg gggtcagccc 1920
cccgcccggc cagccgcccc gtccgggagg gaggtggggg ggatcagccc cccgcccggc 1980
cagccgcccc gtccgggagg gaggtggggg gcgcctctgc ccggccgccc ctgcccggcc 2040
gcccctactg ggaagtgagg agcccctctg cctggccacc accccatctg ggaggtgtgc 2100
ccagcagctc attgagaacg ggccatgatg acaatggcgg ttttgtggaa tagaaaaggc 2160
ggaaaggtgg ggaaaagatt gagaaattgg atggttgccg tgtctgtgta gaaagaagta 2220
gacatgggag acttttcatt ttgttctgta ctaagaaaaa ttcttctgcc ttgggatcct 2280
gttgatctat gaccttaccc ccaacctggt gctctctgaa acatgtgctg tgtccactca 2340
gggttaaatg gattaagggt ggtgcaagat gtgctttgtt aaacagatgc ttgaaggcag 2400
catgctcctt aagagtcatc accactccct aatctcaagt acccagggac acaaacactg 2460
cggaaggcgg cagggtcctc tgcctaggaa aaccagagac ctttgttcac ttgttgatct 2520
gctgaccttc cctccactat tgtcctatga ccctgccaaa tccccctctg cgagaaacac 2580
ccaaaaaaaa 2590
<210> 88
<211> 1920
<212> DNA
<213> 人类
<400> 88
ggcgcggagc tcgggcggcc gtggaggaac tcagcctcgg ccgcaggagg cgccgggagc 60
ggagccgccg ggagtcgcgc aacaggtttc cttctccatc gctgcgccca caggggacgc 120
gcgccctgcc gggagagggg cttctcggtt cgcactctcg ctcccagtcc aggcaaaatg 180
aaagaccggc tagcagaact tctggacttg tccaagcaat atgaccagca gttcccagac 240
ggggacgatg agtttgactc gccccacgag gacatcgtgt tcgagacgga ccacatcctg 300
gagtccctgt accgagacat ccgggacatt caggatgaaa accagctgct ggtggccgac 360
gtgaagcggc tgggaaagca gaacgcccgc ttcctcacgt ccatgcggcg cctcagcagc 420
atcaagcgcg acaccaactc catcgccaag gccatcaagg cccggggcga ggtcatccac 480
tgcaagctgc gcgccatgaa ggagctgagc gaggcggctg aggcccagca cggcccgcac 540
tcggcagtgg cgcgcatttc gcgggcgcag tacaacgcgc tcaccctcac cttccagcgc 600
gccatgcacg actacaacca ggccgagatg aagcagcgcg acaactgcaa gatccgcatc 660
cagcgccagc tggagatcat gggcaaggaa gtctcgggcg accagatcga ggacatgttc 720
gagcagggta agtgggacgt gttttccgag aacttgctgg ccgacgtgaa gggcgcgcgg 780
gccgccctca acgagatcga gagccgccac cgcgaactgc tgcgcctgga gagccgcatc 840
cgcgacgtac acgagctctt cttgcagatg gcggtgctgg tggagaagca ggccgacacc 900
ctgaacgtca tcgagctcaa cgtacaaaag acggtcgact acaccggcca ggccaaggcg 960
caggtgcgga aggccgtgca gtacgaggag aagaacccct gccggaccct ctgctgcttc 1020
tgctgtccct gcctcaagta gcaggccggc ccgggccgcc accgcccatc ccagaccatg 1080
gagcgcgctg ggaaggacgc accaaagccg ggagctctgc cctgcaggga gttgccccaa 1140
ccctttccgg aactcagtct ttagaaaaga aacgccaggt tcaagaattg caaaccagcc 1200
tgtgcttgga aagatggtta gttgataccg tccgatgatt cttcagtaaa gatagattcc 1260
cacaaagttg tgcaatgtca ttatatgaca ccttgcactc ttaccgtctt gacagaagcc 1320
aagtaaggaa ctgaagttgt atctgactgt agggtgaatg tctgaggcct gcctcctaat 1380
aaagactcaa ggaggaagtc aattgggcat ctgctaatag aatgaactca tgatggaaac 1440
ttcagttcat ttactttgtc ctgaaaattc cctggttctg ttccattttg agcgaaattg 1500
gccttgggaa aaaccacgtt cttcctttcc gattcttcat ccggtctacg ctatgcaatt 1560
cctccccaaa tatagatctt atttctgctc atttccccta cttattaaaa tcacaccaaa 1620
cacttactat tttcttatct ctttcacttt ttaaatatct ttcaccaggt tatattttgg 1680
tattattttt ccaaacattt ttaagcactg aatatcgaac aagcactcaa attgaagtat 1740
cagtcatgtt ttgtgtattt ttcgctgata aaaattattt aacatttata tttttacttg 1800
attacatatg cacatgtatg taaatgtaaa atactaatat tcactaatat atgtacataa 1860
tgatcaattg gtttaacttc ttttatgtaa gtatggtata taaatttcaa gacgaaaaaa 1920
<210> 89
<211> 1160
<212> DNA
<213> 人类
<400> 89
gtgtgaagta agcaatctat tttcacttgc tattaacagc aaacgtacaa ctttatctct 60
tatttgactt cattatttgg ctttcaaatt aacaacatga aaactataca gaaattagtc 120
tgtgccctat aagacagaga tttagataat ttgttcaaaa catgagatga tattcagata 180
ttctctcaaa ggcaggactc caacaccgca ggtggaaaac caacaaaagg aagaaaacag 240
aaaggaggaa agggaagatg aaagaccgac ttcaagaact aaagcagaga acaaaggaaa 300
ttgaactctc tagagacagt catgtatcaa ctacagaaac agaggaacaa ggggtgtttc 360
tacagcaagc tgttatttat gaaagagagc ctgtagctga gagacaccta catgaaatcc 420
aaaaactaca ggaaagtatt aacaatttgg cagataatgt tcaaaaattt gggcagcaac 480
agaaaagtct ggtggcttca atgagaaggt ttagtctact taagagagag tctaccatta 540
caaaggagat aaaaattcag gcagaataca tcaacagaag tttgaatgat ttagttaaag 600
aagttaaaaa gtcagaggtt gaaaatggtc catcttcagt ggtcacaagg atacttaaat 660
ctcagcatgc tgcaatgttc cgccattttc agcaaatcat gtttatatac aatgacacaa 720
tagcagcaaa gcaagagaag tgcaagacat ttattttacg tcagcttgaa gttgctggaa 780
aagagatgtc tgaagaagat gtaaatgata tgcttcatca aggaaaatgg gaagttttta 840
atgaaagctt acttacagaa atcaatatca ctaaagcaca actttcagag attgaacaga 900
gacacaagga acttgttaat ttggagaacc aaataaagga tttaagggat cttttcattc 960
agatatctct tttagtagag gaacaaggag agagcatcaa taatattgaa atgacagtga 1020
atagtacaaa agagtatgtt aacaatacta aagagaaatt tggactagct gtaaaataca 1080
aaaaaagaaa tccttgcaga gtactgtgtt gttggtgctg tccatgctgt agctcaaaat 1140
aaagaagcta ttttaaaaaa 1160
<210> 90
<211> 2300
<212> DNA
<213> 人类
<400> 90
gggggccagg tccggtgttg gggtgtccga gttgccgccg gagaggagtg gcctcgcccg 60
cttgagtttt gattcatcat ggataatctg tcatcagaag aaattcaaca gagagctcac 120
cagattactg atgagtctct ggaaagtacg aggagaatcc tgggtttagc cattgagtct 180
caggatgcag gaatcaagac catcactatg ctggatgaac aaaaggaaca actaaaccgc 240
atagaagaag gcttggacca aataaataag gacatgagag agacagagaa gactttaaca 300
gaactcaaca aatgctgtgg cctttgtgtc tgcccatgta atagaacaaa gaactttgag 360
tctggcaagg cttataagac aacatgggga gatggtggag aaaactcacc ttgcaatgta 420
gtatctaaac agccaggccc ggtgacaaat ggtcagcttc agcaaccaac aacgggagca 480
gccagtggtg gatacattaa acgcataact aatgatgcca gagaagatga aatggaagag 540
aacctgactc aagtgggcag tatcctggga aatctaaaag acatggccct gaacataggc 600
aatgagattg atgctcaaaa tccacaaata aaacgaatca cagacaaggc tgacaccaac 660
agagatcgta ttgatattgc caatgccaga gcaaagaaac tcattgacag ctaaagctac 720
tgctgttctt ctttatcatt tattcacttc cgtagctcct ccttgaaagt tattaccttt 780
tcagagttta agttttcggt tccacgctct tctaattggg agataatatg gaagaagggc 840
cagaagcagt tacagccctc cttctttttt gttttctgtt gagggccgac tgctgctctg 900
ccttccttct agtattttct ttctcaattc atacgcttag attggttttc atatgtcatg 960
tttagtgttt tcatcctcct catatacttc agcaggttct tttgctttca agatttggaa 1020
gcattgccaa agacagccat gaagaaggaa gctgtagagg tgttttttgt tgttgtttat 1080
ttttgctttt gtggttgagg gaaggacaag agataagagg ttgttacctc agtaaaaacc 1140
ttcaggccac aaagcaaaaa gttgcatagc cacaacgaag atctagttgg atatagtttt 1200
tgatttaagt tgcagttata gccaatttag gctaatgctt ggttttggag cttttataca 1260
caacgttttt gttaggcatc acagttttgc aacctctgct ccaaagagaa aaatagaatg 1320
agttttcttt cttttttttt tttttggagt cagagtctcg ctctcttgtc caggctggag 1380
tgcaatagcg cgatctgggc tcactgcaac ctccgcctcc ctggttcaag caattctcct 1440
gccttgcctc ctgagtagct gggattacag gcgtgtgtca ccacgctcgg ctaatttttg 1500
tatttttagt agagacaggg tttcaccatg tcaagctggt cttggactcc tgacgtcgtg 1560
atccacccgc cttggcctcc caaagtactg ggattacagg cgtgagccac tgtgcctggc 1620
tgagttttct taaagtgagc ttaatttctg aactcttagt gattcatata tgtacataaa 1680
tctgtgatcc catttcttat tgcaccattc aggaacactt tatataaatg agtggctttt 1740
tatttcatat tattagtagt atcatggttc cattacaggc ctattaacat catacattgt 1800
cattagtctt tgaagaaaaa atatgtaaat atatatgtgt aacatgagaa tttctctcta 1860
aagcagggct taaaattttt tggaaaagtt tgacaaagca taccacatga attcagattt 1920
acctcaatgc taagaattat gtttagttag gaaaaaggaa agtcattttg acctcaggta 1980
gaaaaataga ttgctttgag ttttatgtag ctttagactt taaaaagtta gaatttattc 2040
tgtaactaaa aattatttga aaaaattatg cctctggttt aattattggt gattacacac 2100
tctttctctt acccttgtgt attgaactat gtccataatc aagttgatgt ggatcctgaa 2160
aagtgttatg aacatctgat tggtatttgt cacatttatt ttaaaattag catctgaaca 2220
cttcaaagct gtcagtgtgt attggtttca ccaataacca ctgcttgatc cttacaatta 2280
aattttttaa ctagcaaaaa 2300
<210> 91
<211> 930
<212> DNA
<213> 人类
<400> 91
gcgaggccct ggacggcggc ggcagtgggg ctcctccttc tgtttcccag actgagagcc 60
gcgccggcac catgtcagct taccctaaga gctacaatcc gttcgacgac gacggggagg 120
acgaaggcgc ccggccggcc ccttggaggg acgcccgaga cctccccgac gggcccgacg 180
cgcccgcgga caggcagcag tacttgcggc aggaggtcct ccgcagggct gaggccacgg 240
ccgccagcac cagcaggtcc ctggccctca tgtacgagtc cgagaaggtt ggggtcgcct 300
cttccgagga gctcgcccgt cagcgaggag tcctggagcg cacagagaag atggtggaca 360
agatggacca agatttgaag atcagccaga aacacatcaa tagcattaag agcgtgtttg 420
gggggctggt caattacttc aaatccaaac cagtagagac cccacctgaa cagaatggca 480
ccctcacctc ccagcccaac aacagattga aagaagctat aagtacaagt aaagaacagg 540
aagcaaagta ccaggccagc cacccaaacc ttagaaagct ggatgataca gaccctgtcc 600
ccagaggggc tggttctgcc atgagtactg atgcttaccc aaagaaccca caccttcgag 660
cctatcacca gaagatcgac agcaacctag atgagctgtc catgggactg ggtcgtctga 720
aggacatagc cctggggatg cagacagaaa ttgaggagca agatgacatt cttgaccggc 780
tgacaaccaa agtggacaag ttagatgtca acataaaaag cacagaaaga aaagttcgac 840
aactctgaag acagacggat ttccactcta ttgtgatgaa aagatttgaa agatcttttt 900
ttgaacttcc aagaaatttc atttactatt 930
<210> 92
<211> 840
<212> DNA
<213> 人类
<400> 92
gagcggcggg cggagtctgc aggatggcac cggacccctg gttctccaca tacgattcta 60
cttgtcaaat tgcccaagaa attgctgaga aaattcaaca acgaaatcaa tatgaacgaa 120
aaggtgaaaa ggcaccaaag cttaccgtga caatcagagc tttgttgcag aacctgaagg 180
aaaagatcgc ccttttgaag gacttattgc taagagctgt gtcaacacat cagataacac 240
agcttgaagg ggaccgaaga cagaacctct tggatgatct tgtaactcga gagagactac 300
ttctggcatc ctttaagaat gagggtgccg aaccagatct aatcaggtcc agcctgatga 360
gtgaagaggc taagcgagga gcacccaacc cttggctctt tgaggagcca gaggagacca 420
gaggcttggg ttttgatgaa atccggcaac agcagcagaa aattatccaa gaacaggatg 480
caggccttga tgccctttcc tctatcataa gtcgccaaaa acaaatgggg caggaaattg 540
ggaatgaatt ggatgaacaa aatgagataa ttgacgacct tgccaaccta gtggagaaca 600
cagatgaaaa acttcgcaat gaaaccaggc gggtaaacat ggtggacaga aagtcagcct 660
cttgtgggat gatcatggtg attttactgc tgcttgtggc tatcgtggtt gttgcagtct 720
ggccgaccaa ctgatggcag taaagagacc accagcagtg acacctgcca atgacagatg 780
caagcccaac acccttttgg tacgcaaaac ctgctctcaa taaattcccc caaagctctg 840
<210> 93
<211> 1090
<212> DNA
<213> 人类
<400> 93
ccggggtagg tgggtgacgg cggtcggagg tgtaggaggg agccgtggag gtccaggtga 60
ctgcttagaa aactgcacag catctgatga aattagcgaa taagaacatc aaccatgtct 120
tacactccag gagttggtgg tgaccccgcc cagttggccc agaggatctc ttctaacatc 180
cagaagatca cacagtgttc tgtggaaata caaagaactc tgaatcaact tggaacacct 240
caagattcac ctgaattgag gcaacagttg caacagaagc agcagtatac taaccagctt 300
gccaaagaaa cagataagta cattaaagag tttggatctc tgcccaccac ccccagtgaa 360
cagcgtcaaa ggaaaataca gaaggatcgc ttagtggcag agttcacaac atcactgaca 420
aacttccaga aggtccagag gcaggctgct gagcgagaga aagagtttgt tgctcgagta 480
agagccagtt ccagagtgtc tggcagtttt cctgaggaca gctcaaaaga aaggaatctt 540
gtatcctggg aaagccaaac tcaacctcaa gtgcaggtgc aggatgaaga aattacagag 600
gatgacctcc gtcttattca tgagagagaa tcttctatca ggcaacttga agctgatatt 660
atggatatta atgaaatatt taaagatttg ggaatgatga ttcatgaaca aggagatgta 720
atagatagca tagaagccaa tgtggaaaat gcagaggtgc acgttcagca agcaaatcag 780
cagctgtcaa gggcagcaga ttatcagcgc aaatccagaa aaaccctgtg catcatcatt 840
cttatccttg tcattggagt tgcgattatc agtctcatca tatggggatt gaaccactga 900
agttataaag gagcacactg tcgcactaca ttgtctaaat tatgtaggaa gattcctgta 960
atcatgtttt tttaattatt attttaaagc tattgtataa aggatggttc ccatactttg 1020
ttatttttat tgggggggtt ggggtggttc ctttggatta aatctgatat tttctaatac 1080
tgaaaaaaaa 1090
<210> 94
<211> 1980
<212> DNA
<213> 人类
<400> 94
tgctcggcgg ctccaccaca gttgcaacct gcagaggccc ggagaacaca accctcccga 60
gaagcccagg tccagagcca aacccgtcac tgacccccca gcccaggcgc ccagccactc 120
cccaccgcta ccatggccga agacgcagac atgcgcaatg agctggagga gatgcagcga 180
agggctgacc agttggctga tgagtcgctg gaaagcaccc gtcgtatgct gcaactggtt 240
gaagagagta aagatgctgg tatcaggact ttggttatgt tggatgaaca aggagaacaa 300
ctcgatcgtg tcgaagaagg catgaaccat atcaaccaag acatgaagga ggctgagaaa 360
aatttaaaag atttagggaa atgctgtggc cttttcatat gtccttgtaa caagcttaaa 420
tcaagtgatg cttacaaaaa agcctggggc aataatcagg acggagtggt ggccagccag 480
cctgctcgtg tagtggacga acgggagcag atggccatca gtggcggctt catccgcagg 540
gtaacaaatg atgcccgaga aaatgaaatg gatgaaaacc tagagcaggt gagcggcatc 600
atcgggaacc tccgtcacat ggccctggat atgggcaatg agatcgatac acagaatcgc 660
cagatcgaca ggatcatgga gaaggctgat tccaacaaaa ccagaattga tgaggccaac 720
caacgtgcaa caaagatgct gggaagtggt taagtgtgcc cacccgtgtt ctcctccaaa 780
tgctgtcggg caagatagct ccttcatgct tttctcatgg tattatctag taggtctgca 840
cacataacac acatcagtcc acccccattg tgaatgttgt cctgtgtcat ctgtcagctt 900
cccaacaata ctttgtgtct tttgttctct cttggtctct ttctttccaa aggttgtaca 960
tagtggtcat ttggtggctc taactccttg atgtcctgag tttcattttt cattttctct 1020
cctcggtggc atttgctgaa taacaacaat ttaggaatgc tcaatgtgct gttgattctt 1080
tcaatccaca gtattgttct tgtaaaactg tgacattcca cagagttact gccacggtcc 1140
tttgagtgtc aggctctgaa tctctcaaaa tgtgccgtct ttggttcctc atggctgtta 1200
tctgtcttta tgatttcatg attagacaat gtggaattac ataacaggca ttgcactaaa 1260
agtgatgtga tttatgcatt tatgcatgag aactaaatag atttttagat tcctacttaa 1320
acaaaaactt tccatgacag tagcatactg atgagacaac acacacacac acaaaacaac 1380
agcaacaaca acagaacaac aacaaagcat gctcagtatt gagacactgt caagattaag 1440
ttataccagc aaaagtgcag tagtgtcact tttttcctgt caatatatag agacttctaa 1500
atcataatca tcctttttta aaaaaaagaa ttttaaaaaa gatggatttg acacactcac 1560
catttaatca tttccagcaa aatatatgtt tggctgaaat tatgtcaaat ggatgtaata 1620
tagggtttgt ttgctgcttt tgatggctac gttttggaga gagcaatctt gctgtgaaac 1680
agtgtggatg taaattttat aaggctgact cttactaacc accatttccc ctgtggtttg 1740
ttatcagtac aattctttgt tgcttaatct agagctatgc acaccaaatt gctgagatgt 1800
ttagtagctg ataaagaaac cttttaaaaa aataatataa atgaatgaaa tataaactgt 1860
gagataaata tcattatagc atgtaatatt aaattcctcc tgtctcctct gtcagtttgt 1920
gaagtgattg acattttgta gctagtttaa aattattaaa aattatagac tccaaaaaaa 1980
<210> 95
<211> 1739
<212> DNA
<213> 人类
<400> 95
ctcagtgtgg aggctgctgg ccctgccatc tgtaagaaga tgtcatacgg atccatcgcc 60
cgtggaggtg gcctggggag ccgtggccct ttcgggggac cttcgagaca aggctgtcag 120
cccctagagt gcgctagatg ttggaccgag tatggaatcc gccatttccc ctgcccgtcg 180
ccagagagca agctgcagaa ccgctgtgtg gggaaggacg gggaaggtga tctggggcca 240
gcaggcacgc ctattgtccc aagggccagg aagcgagggc ctggggttgc ccctgaaggc 300
agccggatgc cggagcccac ctcatcaccc accattggcc cgaggaagga ctcggctgct 360
gggccccatg gccggatggc ggggcccagc actacccggg ccaagaagag gaagcccaac 420
ttctgcccgc aggagaccga ggtgctggtg tccaaggtga gcaagcacca ccagctgctg 480
tttggcacgg ggctgctgaa ggccgagccc actcgcaggt accgcgtgtg gagccgcatc 540
ctgcaggccg tgaatgcgct gggctactgt cgccgcgacg ttgtggacct gaagcacaag 600
tggcgggacc tacgagccgt cgtgcggcgc aagctgggcg acctccggaa ggcggcccat 660
ggccccagcc ctggttccgg caagccccag gccctggctc tcacgcccgt ggagcaggtg 720
gtggccaaga ccttctcttg ccaggccctg ccctccgagg gcttcagtct ggagccgccc 780
agagccaccc aggtcgatcc gtgcaacctc caggagctgt tccaggagat gtcggccaac 840
gtcttccgaa tcaactccag tgtgacctcc ttggagcgga gccttcagtc cttagggaca 900
ccgagtgaca cgcaggagct tcgggacagc ctgcacacgg cacagcagga gaccaacaag 960
accattgcag ccagcgccag ctccgtgaag cagatggccg agctgctgcg cagctcctgc 1020
ccgcaggagc gtctgcagca ggagcgtcct cagctggacc ggctgaaaac ccagctctca 1080
gatgccattc agtgctatgg agtggtgcag aagaaaattg cagaaaagtc cagagcgctg 1140
cttcccatgg cgcagagggg cagtaaacag agtccccagg ccccgtttgc cgagctggct 1200
gatgatgaga aggtctttaa cgggagtgac aacatgtggc agggccagga gcaggcgctg 1260
ctcccggaca tcactgaaga ggacctggag gccatccggc tgcgggagga ggccatcctg 1320
cagatggaga gcaacttgct ggatgtgaat cagatcatca aggacttggc ctccatggtg 1380
tcagagcaag gagaagctgt tgatagtatt gaagccagcc ttgaggctgc gtcctcgcat 1440
gcggaggcag cccgccagct cctggctgga gccagccggc accaactcca gagacacaag 1500
atcaagtgct gcttcctatc agctggagtc actgccctgc ttgtcatcat catcatcatc 1560
gccacctctg tccgaaagtg atgctacccg tgcatcggcc gctgaaccgt cagctggctg 1620
tggtgtgggc tctccagccc cgagcacccc tcctggcccg gagctgggag ctgatggagt 1680
ccgctgcgtt gtcagctgat gccgtcacct ggcctgcaat ggacccgaga gcttcacag 1739
<210> 96
<211> 2090
<212> DNA
<213> 人类
<400> 96
gccggcgccg ctgccactcc cgggagcatg aaggaccgaa cccaggagct ccgcacggcc 60
aaggacagcg atgatgatga tgatgtcgct gtcaccgtgg accgagaccg cttcatggat 120
gagttctttg agcaggtgga ggagattcga ggcttcattg acaagatcgc agagaacgtg 180
gaggaggtga agcggaagca cagtgccatc ctggcatccc ccaaccccga tgagaagacg 240
aaggaggagc tggaagaact catgtccgac ataaagaaga cagcaaacaa agttcgttcc 300
aagttaaaga gcatcgagca gtccatcgag caagaggaag gcctgaaccg ctcctccgct 360
gacctgagga tccggaagac acagcactcc acgctgtcca gaaagtttgt ggaggtcatg 420
tcggagtaca acgccacgca gtccgactac cgcgagcgct gcaaaggccg catccagagg 480
cagctggaga tcaccggcag gaccacgacc agtgaggagc tggaggacat gctggagagt 540
gggaaccccg ccatctttgc ctctgggatc atcatggact ccagcatctc gaagcaggct 600
ctgagcgaga ttgagacgcg gcacagtgag atcatcaagc tggagaacag catccgtgag 660
ctacacgaca tgttcatgga catggccatg ctcgtggaga gccagggaga gatgattgac 720
aggatcgagt acaatgtgga acacgcggta gactatgtgg agagggccgt gtctgacacc 780
aagaaggccg tcaagtacca gagcaaggcg cgccggaaga aaatcatgat catcatctgc 840
tgtgtgatcc tgggcatcgt catcgcctcc actgttgggg gcatcttcgc ctagaagcca 900
cccaaactgc cactccactc caggtgggcc actccaagga ggccctggct gctgccacct 960
ggctgggctg ccctcccaac ccccgcctct ggctcagagc accctccctc ccggccccca 1020
tgctcccttc tctgccatgg gccctccgtc cccgccccgt gtcgtgtgca tgatctctgt 1080
gagtgtgcgt ctgtacggga agaggcagag ggaggcagcc agcggggcgt gatgcagtgt 1140
gcacagcgag gagcagaccc aggcagggcc gccagggtga cacaggccac ccttccttgc 1200
cttcagtaac tcggtgggcc caggttctgc tcttccctgg ggaccctaac ctcccctcca 1260
gctgacctgc cctgtcctct ccagctgtcc ccacaagcag agccctgagg ggtggggacc 1320
agctggccac atggtgctgc ttttcaggtt aggggagagg tggccctgag ggacagccca 1380
gctctgagtc tcagtcgctg atcactgcca gggaggctca ggctgccatg gctccaggct 1440
ccctcccctg cctaggggca aagtccatcg ggtcctgggc ctcagcttcc cttcccacat 1500
tcctccggcc ccaggagcaa ccccttgggc taggtctgac cccaggtgtc cctctggaag 1560
gggctggctg gtgccctatt tccagccacc ccagcagcta gggaggcaaa gcaggctgca 1620
gtcagtccct caagccagcg ttgcatgttt gggatggtgg ctcctgttgt cttgcgctct 1680
gggaagtcag atgtcatttc aggcctgcag tctcatcctg cccttgccat cctcccatcg 1740
atgtgccacg tgggtgtcac gtgtcccaga tgcagtattc ggcagccagc cggggagggc 1800
tacctcctcc tcctcaccac cttggggctt ctcatgggaa atgtgccccc gccccaggac 1860
cctctccctt gtggacaggc agggagatgc atgcgagtgc atgcagcagg ggatggggcc 1920
gtgtccgtgt gccccaccct ccctcggctt tactcctgcc cagtgactgt gaccactgtc 1980
cgtgttgcct tcttgaacag cgattccccc caaccccttc accaaaggtc ttggtacaac 2040
cagctgccca ttttgtgaaa tttttatgta gaataaacat ttgtatctgt 2090
<210> 97
<211> 1780
<212> DNA
<213> 人类
<400> 97
gtgacgtggc cgcttccagt ctttggtcgg gtttcggcgg cttcagtgct cggggaggag 60
gcagtgacgg ccggtgagat tggaagtggc ggcggcggca ggcggcagag gggagtccga 120
ggttatgcgt ctcaatgatc ccgcggaaac gctacgggtc taagaacacg gatcagggtg 180
tctacctggg tctctcaaag acacaggtcc tgtcccctgc aactgctggc agtagcagca 240
gcgacatcgc ccctctgccc cccccagtga ccctcgtccc tccccctccc gacaccatgt 300
cctgccggga tcggacccag gagtttctgt ctgcctgcaa gtcgctgcag acccgtcaga 360
atggaatcca gacaaataag ccagctttgc gtgctgtccg acaacgcagt gaattcaccc 420
tcatggccaa gcgcattggg aaagacctta gcaacacatt tgccaagctg gagaagctga 480
caatcttggc aaagcgcaag tccctctttg atgataaagc agtggaaatt gaagagctaa 540
catatatcat caaacaggac atcaatagcc tcaacaaaca aattgctcag ctccaggatt 600
tcgtgagagc caagggcagc cagagtggcc ggcacctgca gacccactcc aacaccattg 660
tggtctcctt gcagtcgaaa ctggcttcta tgtccaatga cttcaaatcg gttttagaag 720
tgaggacaga gaacctgaag cagcagagga gccggagaga gcagttctcc cgggcacctg 780
tgtcagccct gccccttgcc cctaaccacc tgggcggtgg tgctgtggtt ctgggggcag 840
agtcccatgc ctccaaggat gtcgccatcg acatgatgga ctctcggacc agccagcagc 900
tgcagctcat tgacgagcag gattcctaca tccagagtcg ggcagacacc atgcagaaca 960
ttgagtcgac aattgttgag ttgggctcca tctttcagca gttggcacac atggttaagg 1020
aacaggagga aaccattcag aggatcgacg agaacgtgct aggagcccag ctggacgttg 1080
aggccgccca ttcagagatc ctcaagtact tccagtctgt cacctccaac cggtggctca 1140
tggtcaaaat cttcctcatc ctcattgtct tcttcatcat ctttgtggtc ttccttgctt 1200
gaaccctctc tactctgagg cactctgttg gggtttggga ccctcctggg aaggcaagtg 1260
gccagtgctg ccactgagcc tgtgcagggt acttgggaga aaggccctgt ttccctggaa 1320
ctgctaagaa tgaccactgc ccctgatccc ccaccccttg cctctggcca ccctgtcttc 1380
cccccaccac cctcaggcct atgaaacaca cagggttcta gatttgaact ctgctgtgaa 1440
gtgactggaa gggagcagag gccagctggg ggccagtggg ggaggttgtt tccactagga 1500
gatttttata aaccctctcc agcctctccc aaaggaagcg ttggcagcaa agggagatga 1560
tgcccttacc caccttcctg tgagtgaaga gaggaagcag ccccagggac caattttccc 1620
aattgacctc tttcttcctc tttcaccatg tgaggcaggg agccctgagc ccttcagctg 1680
cctgcacaac ccctgacatt ggctgctggt gactcaatct gccaaatgtg ctgcagctcg 1740
ttttctccca attacagcaa gactgtcagc ctcaaaaaaa 1780
<210> 98
<211> 1019
<212> DNA
<213> 人类
<400> 98
tctgtttccc agaccgagag ccgcgccggc accatgtcag cttaccctaa aagctacaat 60
ccgttcgacg acgacgggga ggacgaaggc gcccggccgg ccccttggag ggacgcccga 120
gacctccccg acgggcccga cgcgcccgcg gacaggcagc agtacttgcg gcaggaggtc 180
ctccgcaggg ctgaggccac ggccgccagc accagcaggt ccctggccct catgtacgag 240
tccgagaagg ttggggtcgc ctcttccgag gagctcgccc gtcagcgagg agtcctggag 300
cgcacagaga agatggtgga caagatggac caagatttga agatcagcca gaaacacatc 360
aatagcatta agagcgtgtt tggggggctg gtcaattact tcaaatccaa accagtagag 420
accccacctg aacagaatgg caccctcacc tcccagccca acaacagatt gaaagaagct 480
ataagtacaa gtaaagaaca ggaagcaaag taccaggcca gccacccaaa ccttagaaag 540
ctggatgata cagaccctgt ccccagaggg gctggttctg ccatgagtac tgatgcttac 600
ccaaagaacc cacaccttcg agcctatcac cagaagatcg acagcaacct agatgagctg 660
tccatgggac tgggtcgtct gaaggacata gccctgggga tgcagacaga aattgaggag 720
caagatgaca ttcttgaccg gctgacaacc aaagtggaca agttagatgt caacataaaa 780
agcacagaaa gaaaagttcg acaactctga agacagacgg atttccactc tattgtgatg 840
aaaagatttg aaagatcttt ttttgaactt ccaagaaatt tcatttacta ttttagtatg 900
taaattaatg tgtgtttgca aatgttataa tagagtaggt cttaagacat ttttgctgtt 960
ataaggaagt gtttgtccca cattttccta gggttaacac ctcaccaagt tcttccagc 1019
<210> 99
<211> 1130
<212> DNA
<213> 人类
<400> 99
cggaagtgtc cgcacgtcgg gcctccgagg cttctctttc tcccctggcg gtccggctct 60
cgatggtggc gtgacggggg cgggggtggc ggcgcgttct cctcggttgg gagggaacca 120
gcccgcgaac ccaggccggg aggggggttc ggcctggggg ggaagggact gacatgtctc 180
tcgaagaccc cttttttgta gtccgaggcg aggtgcagaa ggcggtgaac acggcccgcg 240
ggctgtacca gcgctggtgc gagctcctgc aggaaagcgc ggcggtcgga cgcgaggagc 300
tggactggac gaccaatgag ctgcggaatg gcctgcgcag catcgagtgg gacctcgagg 360
acctggaaga gaccatcggt atagtggaag ccaacccagg caagccagct gcccagaagt 420
cacccagcga cctgctggat gccagcgcag tctcggccac atctcgctac atcgaggagc 480
agcaggccac acagcagctg atcatggatg aacaggatca acagctggag atggtgtctg 540
ggagcatcca ggttctgaag cacatgtccg gccgcgttgg agaagagctg gacgagcagg 600
gcatcatgct ggatgccttc gcccaagaga tggaccacac ccagtcccgc atggacgggg 660
tcctcaggaa gttggccaaa gtatcccaca tgacgagtga ccgccgacag tggtgtgcca 720
tcgccgtgct agtgggggtg cttctcctcg ttctcatctt actattctct ctctgacccc 780
agccctccct ggcaggctgg tcccttaagc ctggggagcc accaagcact ttggagctgg 840
cctcgccccc taggaggaga gggtccctcc tgggtagctg gagagtagag ggtcccgcct 900
ggggagctgt ccccatggct ctcccctaga gccagtggga cccttcagga ccctgggctg 960
gaaccaccac cactggtcct gtctcaagtg cacttagggg gtggtggagg cagggacacc 1020
tgagacacac ctgtctccat ttccagttcc aggaccccaa agccatttgc ccctgtgcct 1080
tatacacgtg ccaacctgga aataaaatgt cagccttttt tatatgtaaa 1130
<210> 100
<211> 885
<212> DNA
<213> 人类
<400> 100
atgaaagacc gacttcaaga actaaagcag agaacaaagg aaattgaact ctctagagac 60
agtcatgtat caactacaga aacagaggaa caaggggtgt ttctacagca agctgttatt 120
tatgaaagag agcctgtagc tgagagacac ctacatgaaa tccaaaaact acaggaaagt 180
attaacaatt tggcagataa tgttcaaaaa tttgggcagc aacagaaaag tctggtggct 240
tcaatgagaa ggtttagtct acttaagaga gagtctacca ttacaaagga gataaaaatt 300
caggcagaat acatcaacag aagtttgaat gatttagtta aagaagttaa aaagtcagag 360
gttgaaaatg gtccatcttc agtggtcaca aggatactta aatctcagca tgctgcaatg 420
ttccgccatt ttcagcaaat catgtttata tacaatgaca caatagcagc aaagcaagag 480
aagtgcaaga catttatttt acgtcagctt gaagttgctg gaaaagagat gtctgaagaa 540
gatgtaaatg atatgcttca tcaaggaaaa tgggaagttt ttaatgaaag cttacttaca 600
gaaatcaata tcactaaagc acaactttca gagattgaac agagacacaa ggaacttgtt 660
aatttggaga accaaataaa ggatttaagg gatcttttca ttcagatatc tcttttagta 720
gaggaacaag gagagagcat caacaatatt gaaatgacag tgaatagtac aaaagagtat 780
gttaacaata ctaaagagaa atttggacta gctgtaaaat acaaaaaaag aaatccttgc 840
agagtactgt gttgttggtg ctgtccatgc tgtagctcaa aataa 885
<210> 101
<211> 1106
<212> DNA
<213> 人类
<400> 101
agccggctgc tgagaggccg gtaggcggcg gcggtcccga ggggcggcgg ccgcgctgct 60
ccctgagaac gggtcccgca gctgggcagg cgggcggcct gagggcgcgg agccatgaag 120
ctgtacagcc tcagcgtcct ctacaaaggc gaggccaagg tggtgctgct caaagccgca 180
tacgatgtgt cttccttcag ctttttccag agatccagcg ttcaggaatt catgaccttc 240
acgagtcaac tgattgtgga gcgctcatcg aaaggcacta gagcttctgt caaagaacaa 300
gactatctgt gccacgtcta cgtccggaat gatagtcttg caggtgtggt cattgctgac 360
aatgaatacc catcccgggt ggcctttacc ttgctggaga aggtactaga tgaattctcc 420
aagcaagtcg acaggataga ctggccagta ggatcccctg ctacaatcca ttacccagcc 480
ctggatggtc acctcagtag ataccagaac ccacgagaag ctgatctcat gactaaagtg 540
caggccgaac tagatgagac caaaatcatt ctgcacaaca ccatggagtc tctgttagag 600
cgaggtgaga agctagatga cttggtgtcc aaatccgagg tgctgggaac acagtctaaa 660
gccttctata aaactgcccg gaaacaaaac tcatgctgtg ccatcatgtg atgcagcctg 720
ccagaggccc aatgctggaa tggcaccatc attcacatca gaactgcagc ccctggaaaa 780
gaagagacag ccatagacga ggagccagag tgggggcaga ctggccattt ttattttgaa 840
gttcctgcga gaaatggatg gtggaagggt ggcgaatgtt caaattcata tgtgtggtag 900
tgattcttgg aaagaatttg aggtccccaa aggtgtattt ttgggcaaat gaaaccataa 960
actccgactg gcttctgtag atgccaaagg gctctttttc agctaaccct gggaaggctc 1020
tgtgggaggg aggtcggagc cagctgtttc tcgatctttg gtatatcttt ggatcttatt 1080
tgtacattaa tgatattaac actcca 1106
<210> 102
<211> 840
<212> DNA
<213> 人类
<400> 102
atgcaactga cacaggatga tgatactgat gcggttgaga ttgctatcga caacacggct 60
tttatggacg agttcttttc tgagattgag gaaactcggc ttaacattga caagatctca 120
gaacatgtag aggaggctaa gaaactctac agtatcattc tctctgcacc gattccagag 180
ccaaaaacca aggatgacct agagcagctc agcactgaga ttaagaaaag ggccaacaac 240
gtccggaaca aactgaagag catggagaag catattgaag aagatgaggt caggtcatcg 300
gcagaccttc ggattcggaa atcccagcac tctgtccttt ctcggaagtt tgtggaggtg 360
atgaccaaat acaatgaagc tcaagtggac ttccgagaac gcagcaaagg gcgaatccag 420
cggcagctcg aaattactgg caaaaagaca accgatgagg agctggagga gatgttggag 480
agtggcaacc cggccatctt cacttctggg atcattgact cacagatttc caagcaagcc 540
ctcagtgaga ttgagggacg acacaaggac attgtgaggc tggagagcag catcaaggag 600
cttcacgaca tgtttatgga catcgccatg ctggtggaga atcagggtga gatgttagat 660
aacatagagt tgaatgtcat gcacacagtg gaccacgtgg agaaggcacg agatgaaagc 720
aaaaaagctg tgaaatacca gagtcaggcc cggaagaaat tgataattat cattgtgcta 780
gtagttgtgt tgctgggcat tttagcattg attattggac tttccgttgg cctgaattaa 840
<210> 103
<211> 894
<212> DNA
<213> 人类
<400> 103
atgcgcgaca ggacccacga gctgagacag ggggatgaca gctcggacga agaggacaag 60
gagcgggtcg cgctggtggt gcacccgggc acggcacggc tggggagccc ggacgaggag 120
ttcttccaca aggtccggac aattcggcag actattgtca aactggggaa taaagtccag 180
gagttggaga aacagcaggt caccatcctg gccacgcccc ttcccgagga gagcatgaag 240
caggagctgc agaacctgcg cgatgagatc aaacagctgg ggagggagat ccgcctgcag 300
ctgaaggcca tagagcccca gaaggaggaa gctgatgaga actataactc cgtcaacaca 360
agaatgagaa aaacccagca tggggtcctg tcccagcaat tcgtggagct catcaacaag 420
tgcaattcaa tgcagtccga ataccgggag aagaacgtgg agcggattcg gaggcagctg 480
aagatcacca atgctgggat ggtgtctgat gaggagttgg agcagatgct ggacagtggg 540
caaagcgagg tgtttgtgtc caatatcctg aaggacacgc aggtgactcg acaggcctta 600
aatgagatct cggcccggca cagtgagatc cagcagcttg aacgcagtat tcgtgagctg 660
cacgacatat tcacttttct ggctaccgaa gtggagatgc agggggagat gatcaatcgg 720
attgagaaga acatcctgag ctcagcggac tacgtggaac gtgggcagga gcacgtcaag 780
acggccctgg agaaccagaa gaaggcgagg aagaagaaag tcttgattgc catctgtgtg 840
tccatcaccg tcgtcctcct agcagtcatc attggcgtca cagtggttgg ataa 894
<210> 104
<211> 768
<212> DNA
<213> 人类
<400> 104
atgtccatgg aggacccctt ctttgtggtg aaaggagagg tacagaaagc agtcaacact 60
gcccagggat tgtttcagag atggacagag ctcctccagg acccctccac agcaacaagg 120
gaagaaatcg actggaccac caacgagctg agaaataacc tccggagcat agagtgggat 180
ctagaggacc ttgatgaaac catcagcata gttgaagcaa atcctagaaa atttaacctt 240
gatgcaactg aattgagtat aagaaaagcc ttcattacaa gtactcggca agttgtcagg 300
gacatgaaag atcagatgtc aacttcatct gtgcaggcat tagctgaaag aaaaaataga 360
caggcactgc tgggagacag tggcagccag aactggagca ctggaacaac agataaatat 420
gggcgtctgg accgagagct ccagagagcc aattctcatt tcattgagga gcagcaggca 480
cagcagcagt tgatcgtgga acagcaggat gagcagttgg agctggtctc tggcagcatc 540
ggggtgctga agaacatgtc ccagcgcatc ggaggggagc tggaggaaca ggcagttatg 600
ttggaagatt tctctcacga attggagagc actcagtccc ggctggacaa tgtgatgaag 660
aaacttgcaa aagtatctca tatgaccagt gatcggcgcc aatggtgtgc catagccatc 720
ctctttgcag tcctgttggt tgtgctcatc ctcttcctag tgctgtga 768
<210> 105
<211> 870
<212> DNA
<213> 人类
<400> 105
atgaaggacc gtctggagca gctgaaggcc aagcagctga cacaggatga tgatactgat 60
gcggttgaga ttgctatcga caacacggct tttatggacg agttcttttc tgagattgag 120
gaaactcggc ttaacattga caagatctca gaacatgtag aggaggctaa gaaactctac 180
agtatcattc tctctgcacc gattccagag ccaaaaacca aggatgacct agagcagctc 240
acgactgaga ttaagaaaag ggccaacaac gtccggaaca aactgaagag catggagaag 300
catattgaag aagatgaggt caggtcatcg gcagaccttc ggattcggaa atcccagcac 360
tctgtccttt ctcggaagtt tgtggaggtg atgaccaaat acaatgaagc tcaagtggac 420
ttccgagaac gcagcaaagg gcgaatccag cggcagctcg aaattactgg caaaaagaca 480
accgatgagg agctggagga gatgttggag agtggcaacc cggccatctt cacttctggg 540
atcattgact cacagatttc caagcaagcc ctcagtgaga ttgagggacg acacaaggac 600
attgtgaggc tggagagcag catcaaggag cttcacgaca tgtttatgga catcgccatg 660
ctggtggaga atcagggtga gatgttagat aacatagagt tgaatgtcat gcacacagtg 720
gaccacgtgg agaaggcacg agatgaaacg aaaaaagctg tgaaatacca gagtcaggcc 780
cggaagaaat tgataattat cattgtgcta gtagttgtgt tgctgggcat tttagcattg 840
attattggac tttccgttgg gctgaattaa 870
<210> 106
<211> 893
<212> DNA
<213> 人类
<400> 106
gcccgcgaac ccaggccggg aggggggttc ggcctggggg ggaagggact gacatgtctc 60
tcgaagaccc cttttttgta gtccgaggcg aggtgcagaa ggcggtgaac acggcccgcg 120
ggctgtacca gcgctggtgc gagctcctgc aggaaagcgc ggcggtcgga cgcgaggagc 180
tggactggac gaccaatgag ctgcggaatg gcctgcgcag catcgagtgg gacctcgagg 240
acctggaaga gaccatcggt atagtggaag ccaacccagg caagttcaag ctcccagccg 300
gggacctgca ggagagaaag gtgttcgtgg agcggatgcg agaggcagtc caggaaatga 360
aggaccatat ggtcagccca acagccgtag catttttgga gaggaataac agagagatac 420
tcgcaggcaa gccagctgcc cagaagtcac ccagcgacct gctggatgcc agcgcagtct 480
cggccacatc tcgctacatc gaggagcagc aggccacaca gcagctgatc atggatgaac 540
aggatcaaca gctggagatg gtgtctggga gcatccaggt tctgaagcac atgtccggcc 600
gcgttggaga agagctggac gagcagggca tcatgctgga tgccttcgcc caagagatgg 660
accacaccca gtcccgcatg gacggggtcc tcaggaagtt ggccaaagta tcccacatga 720
cgagtggtga gtcccctcag gggaggggtc agtcctggtg ggggcaggtt gtaggtggta 780
ccctctcccc gtgacccctg accttctcgt tcccagaccg ccgacagtgg tgtgccatcg 840
ccgtgctagt gggggtgctt ctcctcgttc tcatcttact attctctctc tga 893
<210> 107
<211> 783
<212> DNA
<213> 人类
<400> 107
atgaaggacc gaacccagga gctccgcacg gccaaggaca gcgatgatga tgatgatgtc 60
gctgtcaccg tggaccgaga ccgcttcatg gatgagttct ttgagcaggt ggaggagatt 120
cgaggcttca ttgacaagat cgcagagaac gtggaggagg tgaagcggaa gcacagtgcc 180
atcctggcat cccccaaccc cgatgagaag acgaaggagg agctggaaga actcatgtcc 240
gacataaaga agacagcaaa caaagttcgt tccaagttaa agagcatcga gcagtccatc 300
gagcaagagg aaggcctgaa ccgctcctcc gctgacctga ggatccggaa gacacagcac 360
tccacgctgt ccagaaagtt tgtggaggtc atgtcggagt acaacgccac gcagtccgac 420
taccgcgagc gctgcaaagg ccgcatccag aggcagctgg agatcaccgg caggaccacg 480
accagtgagg agctggagga catgctggag agtgggaacc ccgccatctt tgcctctggg 540
atcatcatgg actccagcat ctcgaagcag gctctgagcg agattgagac gcggcacagt 600
gagatcatca agctggagaa cagcatccgt gagctacacg acatgttcat ggacatggcc 660
atgctcgtgg agagccagcc tcagggtgct ttcctgaagt cctgccccga gccccaaccc 720
aaccctgagg agggggccct ttggagctcg ggtgcccccg gccccgcagg gagagatgat 780
tga 783
<210> 108
<211> 711
<212> DNA
<213> 人类
<400> 108
atggcaccgg acccctggtt ctccacatac gattctactt gtcaaattgc ccaagaaatt 60
gctgagaaaa ttcaacaacg aaatcaatat gaacgaaaag gtgaaaaggc accaaagctt 120
accgtgacaa tcagagcttt gttgcagaac ctgaaggaaa agatcgccct tttgaaggac 180
ttattgctaa gagctgtgtc aacacatcag ataacacagc ttgaagggga ccgaagacag 240
aacctcttgg atgatcttgt aactcgagag agactacttc tggcatcctt taagaatgag 300
ggtgccgaac cagatctaat caggtccagc ctgatgagtg aagaggctaa gcgaggagca 360
cccaaccctt ggctctttga ggagccagag gagaccagag gcttgggttt tgatgaaatc 420
cggcaacagc agcagaaaat tatccaagaa caggatgcag gccttgatgc cctttcctct 480
atcataagtc gccaaaaaca aatggggcag gaaattggga atgaattgga tgaacaaaat 540
gagataattg acgaccttgc caacctagtg gagaacacag atgaaaaact tcgcaatgaa 600
accaggcggg taaacatggt ggacagaaag tcagcctctt gtgggatgat catggtgatt 660
ttactgctgc ttgtggctat cgtggttgtt gcagtctggc cgaccaacta g 711
<210> 109
<211> 597
<212> DNA
<213> 人类
<400> 109
atgaagctgt acagcctcag cgtcctctac aaaggcgagg ccaaggtggt gctgctcaaa 60
gccgcatacg atgtgtcttc cttcagcttt ttccagagat ccagcgttca ggaattcatg 120
accttcacga gtcaactgat tgtggagcgc tcatcgaaag gcactagagc ttctgtcaaa 180
gaacaagact atctgtgcca cgtctacgtc cggaatgata gtcttgcagg tgtggtcatt 240
gctgacaatg aatacccatc ccgggtggcc tttaccttgc tggagaaggt actagatgaa 300
ttctccaagc aagtcgacag gatagactgg ccagtaggat cccctgctac aatccattac 360
ccagccctgg atggtcacct cagtagatac cagaacccac gagaagctga tcccatgact 420
aaagtgcagg ccgaactaga tgagaccaaa atcattctgc acaacaccat ggagtctctg 480
ttagagcgag gtgagaagct agatgacttg gtgtccaaat ccgaggtgct gggaacacag 540
tctaaagcct tctataaaac tgcccggaaa caaaactcat gctgtgccat catgtag 597
<210> 110
<211> 411
<212> DNA
<213> 人类
<400> 110
atggcggggg ctggttccgc cgctgtatcg ggggcaggga ccccggtggc ggggcccaca 60
ggccgcgacc ttttcgccga agggctgctg gagttcctgc gacccgctgt gcagcagctc 120
gactctcacg tacacgccgt cagagagagc caggtagagc tccgggaaca aattgacaac 180
ctagccacag aactgtgccg cataaatgag gatcagaagg tggccctgga tcttgacccc 240
tatgttaaga agctacttaa tgcccggcga cgcgttgtct tggttaacaa cattctacag 300
aatgctcagg aacgactgag acggctaaac cacagtgttg ccaaggaaac agcccgcagg 360
agagcaatgc tggattcggg aatttacccc cctggctccc caggcaaata g 411
<210> 111
<211> 636
<212> DNA
<213> 人类
<400> 111
atggataatc tgtcatcaga agaaattcaa cagagagctc accagattac tgatgagtct 60
ctggaaagta cgaggagaat cctgggttta gccattgagt ctcaggatgc aggaatcaag 120
accatcacta tgctggatga acaaaaggaa caactaaacc gcatagaaga aggcttggac 180
caaataaata aggacatgag agagacagag aagactttaa cagaactcaa caaatgctgt 240
ggcctttgtg tctgcccatg taatagaaca aagaactttg agtctggcaa ggcttataag 300
acaacatggg gagatggtgg agaaaactca ccttgcaatg tagtatctaa acagccaggc 360
ccggtgacaa atggtcagct tcagcaacca acaacgggag cagccagtgg tggatacatt 420
aaacgcataa ctaatgatgc cagagaagat gaaatggaag agaacctgac tcaagtgggc 480
agtatcctgg gaaatctaaa agacatggcc ctgaacatag gcaatgagat tgatgctcaa 540
aatccacaaa taaaacgaat cacagacaag gctgacacca acagagatcg tattgatatt 600
gccaatgcca gagcaaagaa actcattgac agctaa 636
<210> 112
<211> 477
<212> DNA
<213> 人类
<400> 112
atggataatc tgtcatcaga agaaattcaa cagagagctc accagattac tgatgagtct 60
ctggaaagta cgaggagaat cctgggttta gccattgagt ctcaggatgc aggaatcaag 120
accatcacta tgctggatga acaaaaggaa caactaaacc gcatagaaga aggcttggac 180
caaataaata aggacatgag agagacagag aagactttaa cagaactcaa caaatgctgt 240
ggcctttgtg tctgcccatg taatagcata actaatgatg ccagagaaga tgaaatggaa 300
gagaacctga ctcaagtggg cagtatcctg ggaaatctaa aagacatggc cctgaacata 360
ggcaatgaga ttgatgctca aaatccacaa ataaaacgaa tcacagacaa ggctgacacc 420
aacagagatc gtattgatat tgccaatgcc agagcaaaga aactcattga cagctaa 477
<210> 113
<211> 693
<212> DNA
<213> 人类
<400> 113
ctctaaagcg ccgcagctgc caaaatgtct acaggtccaa ctgctgccac tggcagtaat 60
cgaagacttc agcagacaca aaatcaagta gatgaggtgg tggacataat gcgagttaac 120
gtggacaagg ttctggaaag agaccagaag ctctctgagt tagacgaccg tgcagacgca 180
ctgcaggcag gcgcttctca atttgaaacg agcgcagcca agttgaagag gaaatattgg 240
tggaagaatt gcaagatgtg ggcaatcggg attactgttc tggttatctt catcatcatc 300
atcatcgtgt gggttgtctc ttcatgaaga accagcggaa ctcaaaactg ctgttcaaga 360
aacctcttca agacttttga cttagaacct gctatattat caagcttacc tactgttatc 420
tctaaaattt tttttgtgtt aatgtaaagt tgaatttcta ggaaacgtgc ctttgttttt 480
taatatgcac tccaaattag aaggccggcc ccgtccacat tttgcacagt gcctttacag 540
atttacgtat gggctgatga agaggccttc ttaagttcca gagtgctata atctagatgt 600
aatgttgtca ctaattaatt gccattactc ccctttagag cacaatggat ctcgagggat 660
cttccatacc taccagttct gcgcctgcag gtc 693
<210> 114
<211> 760
<212> DNA
<213> 人类
<400> 114
atggccacca ggcgtttaac cgacgctttc ttgttgttgc ggaataattc catccaaaac 60
cggcagctgt tagccgagca agagctggac gagcttgctg atgaccgtat ggcactggtg 120
tcaggcatca gcttagatcc agaagcagcg attggtgtga caaaacggcc acctcctaag 180
tgggtggatg gagtggatga aattcagtat gatgttggcc ggattaagca gaagatgaaa 240
gaattggcca gccttcatga caagcattta aacagaccca ccctggatga cagcagcgaa 300
gaggaacatg ccattgagat aactacccaa gagatcactc agctcttcca caggtgccag 360
cgtgccgtgc aggccctgcc gagccgggcc cgggcctgct ccgagcagga ggggcggctg 420
cttgggaacg tggtggcctc gctggcgcag gccctgcagg aactctccac cagcttccgg 480
cacgcacagt caggctacct caaacgcatg aagaatcgag aggaaagatc ccagcatttt 540
ttcgacacat cagtaccact aatggatgat ggagacgata acactcttta ccatcggagg 600
accagttagt tctggtggag cagaacacac tgatggtgga agagcgggaa cgagagattc 660
gccagattgt acagtccatt tctgacctga atgaaatatt cagggactta agggcgatga 720
ttgtagaaca gggtacagtc cttgacagaa ttgactataa 760
<210> 115
<211> 2492
<212> DNA
<213> 人类
<400> 115
gaattccggc agttggcgac cctgcactga cccgcgtccc tccgtcccga gcccgcgcgc 60
cctcagaggg tgcccggaca gactgaagcc atggcgattc tttttgctgt tgttgccagg 120
gggaccacta tccttgccaa acatgcttgg tgtggaggaa acttcctgga ggtgacagag 180
cagattctgg ctaagatacc ttctgaaaat aacaaactaa cgtactcaca tggcaattat 240
ttgtttcatt acatctgcca agacaggatt gtatatcttt gtatcactga tgatgatttt 300
gaacgttccc gagcctttaa ttttctgaat gagataaaga agaggttcca gactacttac 360
ggttcaagag cacagacagc acttccatat gccatgaata gcgagttctc aagtgtctta 420
gctgcacagc tgaagcatca ctctgagaat aagggcctag acaaagtgat ggagactcaa 480
gcccaagtgg atgaactgaa aggaatcatg gtcagaaaca tagtctgtca ccttcaaaac 540
taccagcaga aatcttgctc gagccatgtg tatgaagaac ctcaagctca ctattatcat 600
catcatcgta tcaattgtgt tcatctatat cattgtttca cctctctgtg gtggatttac 660
atggccaagc tgtgtgaaga aataggaaag aagaagttac cattaaccaa ggatatgaga 720
gaacaaggag ttaaaagcaa tccatgtgac tcaagccttt cacatactga cagatggtat 780
ctgccagtct cttcaaccct cttctcactt tttaaaatct tgttccatgc ctccaggttt 840
atctttgtct tatctaccag tttattcctg tgaacttcag attgaaccat tcattgcagc 900
agtagcctta aaaaggcttt tgtttatttc tttggtttgt taactagtgt catctattta 960
gagaaacatt tttgttttta attgctcaaa gctgtcgccg ctagtcttat gagctatcta 1020
ctaaaactat ggagaaactt tgtatgtgca cacaaaagta ttcaagagac agtattgcta 1080
acatctcatc ttaatgtctt ttgttattga gaagttttag gtgcttcaaa acaatataaa 1140
tggataatag ttgttatttg gggaattgta atgatgttgg tgctgcttcc ttctaagagc 1200
tcagacaagt aaagtatgaa acattcttat ttcagttaga tggggaacat tttgctagcc 1260
cattagaagc acacagaatt atccttgtcc tcctaatatt gactttcagg aataaagttc 1320
agtgtgctga tcattcacaa tacagtggat agcttgatat cttctgtttt cccattgcag 1380
ttgatttgag aagatgaagg tttaaatatt gttgaaagtt gcagtttttt aaatgtgttc 1440
ctttttcttc tgtgaatatt tagggcaatc gtgtcgctaa tagaatatgt agtagagggg 1500
gtggggaggt aaattcctct gacttgccaa agaaaaagaa gggaaccaca gtggatatgc 1560
tagcatttta gctgtgcaaa gggaggtagt gtgggaaaag tgtttccatt ctgggaaaag 1620
cccaaaccga atacggtcag cagtcaactc cagggtttgg gcttgattcc tgttgaataa 1680
tagttttgag cattctttgt ggttaaataa attcttaaat ctgcctagtt ttgatgaatt 1740
cttttgtgaa acttgaaaga gaatagacag tatgacatat agaattaata caaaacagtt 1800
taacaaccat ttaactgcag tgtaagaaaa ttggactgta atcatatcgc tactggcatc 1860
tgttatctag tatgcatttc tggtgtgtat ctgaaaggaa gacattttct accctagatc 1920
caattgcatt tatttatcaa taagtgccat taaattgaaa ttatattaca ttttacactt 1980
tctcaatgaa tgaacaaatt agtctgtaga atctagccac ctgtttagcc tagtcatgtg 2040
ccttgaacat atatgtgtcc cataatctgg ctcatggtac ctgttcttct atccaaacct 2100
ttcaattcat gctacctgat tcatttattt gacatagatc ttaggcccac ttgaactctt 2160
ttcttgttta tctagcatag cacaaacgtt tttccagtct tctttatcaa cactaatgcc 2220
tcttaattgc atcagtattt cctattggaa aatacatctg ttccagaaaa acatttggca 2280
ttcctgaata atttccaaat gtttttaatc caaagaaaaa ggtttaaagc ttatttccct 2340
ttcttataca cacctgaata aaattgatgt gcatgtttta gggatcaatt acctaactgt 2400
tccttggtct atttatgtat aagaatgctt tttaaagcac atgtctcatt ttaaatgacg 2460
cacaaactga agatgttaat aaaatggaat tc 2492
<210> 116
<211> 1580
<212> DNA
<213> 人类
<400> 116
gctatggcgg tggacatcac gctgctattc cgggccagcg tcaagaccgt gaagacgcgg 60
aacaaggcgc tgggagtggc ggtgggcggc ggggtcgatg gcagccggga cgagctgttc 120
cgccggagcc cccggcccaa gggcgacttc tccagccggg cccgcgaagt gatttctcac 180
attggcaaac tgagagattt tcttctggaa cacaggaaag attatattaa tgcttatagc 240
cataccatgt ctgaatatgg gaggatgaca gacacagaac gagaccagat agaccaggat 300
gcccagatat tcatgaggac ctgttcagaa gcaattcagc aactacgaac agaagctcac 360
aaggagatac attcccagca agtgaaggag cacaggaccg ctgttttgga tttcattgaa 420
gattacttga aaagagtatg taaactttac tcagaacaga gagccatccg agttaaaaga 480
gtggtggata agaaaagatt atctaagctg gaaccagaac caaatacaaa gacaagagaa 540
tccacatctt ctgagaaagt ttcacagagt ccttcaaaag actctgaaga aaaccctgcc 600
actgaagaac gtccagaaaa aattttggct gaaacacaac ctgaattggg aacgtgggga 660
gatggcaaag gcgaagatga gttatcccca gaagaaatac aaatgtttga acaggaaaat 720
cagcgactaa ttggtgaaat gaacagcttg tttgatgaag tgaggcaaat cgaagggaga 780
gtggttgaga tttccagact ccaagagata ttcacggaaa aggttttgca acaggaagct 840
gagattgaca gcattcacca gttagttgtg ggggcaactg aaaatatcaa ggaaggcaac 900
gaagacataa gagaggccat taaaaacaac gctggcttcc gcgtgtggat cctcttcttc 960
ctcgtgatgt gctccttctc cttgctcttc ctcgactggt acgacagcta gccagggcca 1020
cgggggccca gcacgagagt cctcatgggc actcacagac tgcgtgcttt catgtacttc 1080
cagtgctgga gcatggtatg accagatttt atcacagtgc catttgaagg gaaaggagtt 1140
cagacagaca gacgtattcc ccaaaaaggg ataccccagg ccgatggtgt tcagccattt 1200
agcagctgaa aaaggaaaca gtgcacacca atgggaggca gcctgcgtag ccctcatcag 1260
gcaagacaga ctgaatgcag gagtgggtga ttagctgctc cttgaacttg aggctgcctt 1320
ggcagcaggg gcacagcagg cctcaagagc ccctaattgt ctcagggttc aaaggaagac 1380
actgaccttt cccatcccgg tagcttcagg gaagatcata gttaataacg tctctcaaca 1440
aatgattact tctttgtttc cttgtggctt cttgtctgtc tgagtcaacg aatacacaga 1500
cttactggat tatagaagag aaaattcaca tctgccttgt taatctaata aatataatta 1560
cagcccctta aaaaaaaaaa 1580
<210> 117
<211> 5530
<212> DNA
<213> 人类
<400> 117
ggcggcccct gcagggcagc tgaagccatg gaagcctccg caggtcgctg atcagggcca 60
ggcggctgca gcagcgactg cagaggcgct gcgccaagcc gggccggagt ggtgcgagcc 120
ggcggggctg cggagggcca gtggactcag ggttgttgag aggagtcaat ggcataatac 180
gggaagcccc gaaccacggg ccaactggga agttgatggt cggcgagacc agcccatcct 240
aatttggggt tcctggtcct gctccaggag tcctacagcc tgcagcccct accagagagg 300
gaggactgaa cagcaagggg gtgtgtgggt ctgagtatca gggtcctggg gaagaagcag 360
gcctggctcg tagagtagaa gactcggtgc cggcagtcag gaggccctgc tcctgaagcc 420
tctgtgacct tgggcacggc cttcactctg tctggggcac attcactcat ctggagaaca 480
cagggttgga ctgattactt ttagccactc ctgacagttg tggttttaag ttgggtggtg 540
ggaacctgtg caccagccct attcaattca ctggtggagg cagccgtggt ctgccaggcc 600
ctcgctcctg gggtgtcctg ccgaagggtg agaagagaag ccatgccggg cagcggcccc 660
agcgagagga tgacgtggcc tggcccggcc ctttctgcgg gccccccaac ccgccctctc 720
tcctcagccc ccgggatacc gcccatccca ccccttactc ggacccacag cctcatggcc 780
atgtccctgc caggaagtag acggacctct gctggatcac gcaggcgcac ctctccacct 840
gtgagcgtgc gggatgccta cggcacctct tcgctcagca gcagcagcaa ttctggctcc 900
tacaagggca gtgacagcag tcccacgcca aggcgctcca tgaaatacac gctgtgcagt 960
gacaaccatg gcatcaagcc cccgaccccg gagcagtacc tgacccccct gcagcagaag 1020
gaggtgtgca tccggcacct gaaagcccgg ctgaaggaca cacaggaccg gctccaggac 1080
cgggacacag agattgatga cctgaagacg cagctgtcac gcatgcagga ggactggatt 1140
gaggaggagt gccaccgcgt ggaggcccag ctggccctga aggaggcccg aaaggagatc 1200
aagcagctca agcaggtcat cgacactgtc aagaacaacc tgattgacaa ggacaagggg 1260
ctgcagaagt acttcgtgga catcaacatc cagaacaaga agctggagac gctgctgcac 1320
agcatggagg tggcccagaa tggcatggcc aaggaggatg gcactgggga gtcagccggt 1380
gggtcccctg cccgctccct cacccgcagc tccacctaca ccaagctgag tgacccggct 1440
gtctgtggtg accgccagcc gggtgatccc tccagcggct ctgctgagga tggggcagac 1500
agtggctttg cagcagccga tgacacactg agccggacgg acgcgctgga agccagcagc 1560
ctgctgtcgt cgggggtgga ctgtggcacc gaggagacct cgctgcacag ctccttcggc 1620
ctgggccccc gcttccctgc cagcaacacc tatgagaagc tgctgtgtgg catggaggct 1680
ggtgtgcagg ccagctgcat gcaggagcgt gccatccaga cagacttcgt gcagtaccag 1740
cctgaccttg acaccatcct ggagaaagtg acccaggccc aggtctgtgg gacagaccct 1800
gagtcagggg acaggtgccc agagctggat gcccaccctt cagggcccag agaccccaac 1860
tcagcagtgg tggtgacagt gggtgatgag ctagaggccc cagagcccat cacccgtgga 1920
cccaccccac agcggcctgg tgccaacccc aaccctggcc agtcggtgag cgtggtgtgc 1980
cccatggaag aggaggagga ggctgccgtg gctgagaagg agcccaagag ctactggagc 2040
cgccactaca tcgtggatct gctggctgtg gtggtgccgg ccgtgcccac ggtggcctgg 2100
ctttgccgct cccagcggcg ccagggccag cccatctaca acatcagctc cctgctgcgg 2160
ggctgctgca ctgtggcctt gcactccatc cgcaggatca gctgccgctc gctgagccag 2220
ccgagtccca gcccagcggg cggcggctcc cagctctgag ggggcccatt ccggcagcgg 2280
cgcctgcggc ctgaccactg attgtaggga tgccgttccc ccctcccttc tcccatgggc 2340
atcatcttat ttatttagtt ttgggtgtgg aactgtttct ttttttcaag atgttaaaac 2400
agtcccgtgg aaggagcagg ggttggagaa aggcatccca aagcttcgat ggagagcagg 2460
gaagggggac ccaaggcagg aggtacacca gctggacaaa ttgcagggag gggagggagc 2520
gagggccaac ccggcccctc tgtccccttg gctcttcaga cagggccagc cctgctcagg 2580
aagtctctgg ctgtcttcat gtggggaagc cgggcttgag ttgcccatag gcccctgccc 2640
tgcaccatcc tgtccagtgc cctgcgcact ccatgccgtc tcttccaagc caccttgccc 2700
gcagcccagg ctcctgggcc agtgctctct cctcaaatgg aggcagccat ggcctgaagt 2760
gcagatcact gacccagggc tcagagcaga ggccagaacc actgggccgg ccggcattcc 2820
agcctcccca gactgctgcc caccttggga ctcaggagct cagtcaaggc cacaggctgg 2880
aggagagacg gggctgggcg caaggtggcg gagggcagtg tgggttctgt gtctgtctgt 2940
tcatcccagg ctttcccgtc atccctttcc tcttggcact tctgggtgtg tcagtcatta 3000
ttcctgtgag gtagctaagc ccggcaagct cagtgctggg gtaggagggc ctgcctgagt 3060
cccagctccc agctggagaa tccaccagca caagaagagg aggcaggggc agaaacccaa 3120
gggggctccc ccagccttcc aaggtgaggc catctcatct gcaggctggg aggcagggct 3180
ggactcagga acccacagct tactgaaaaa gccagaggcc atgactgccc ccagaaactt 3240
gccccgagtt tctctggggc cctcgggccc aacttctgct ttgcactatg ttcactttgg 3300
ggttggttct cagccatcca agggtctcca gtgaggtggc tgcttgctgt ctgagatgag 3360
ggttcctaaa ccttaaacct ctctgcctct ggaggagggt ggggtattct ggcaggatga 3420
atcgcaggat ggcgcgtact gaagccacga tgttcatcca ggccaaagca gggtgtcctg 3480
ggataggttt cctaggcagg ggcgtggcag agcaggtagg cgccctgcac cctccctgct 3540
cccagcccaa ggccagtcgg cctgggaagt tcactgcccc aactcttttc ccgggaccat 3600
actgagtccc ccagccacgc tgctgacatt accattatta ttttaccaag taaactcact 3660
ccttttcccc cacaggggtt acacccatct ggttgtccca cccactcttc agaggctagg 3720
ccccacctct gggggttgga gggaccctgt gtcttactcg cccctctggc ctaagggcca 3780
ctctggttat ctgccaaggt tgcttgccct caccccaatg ctccaacagc cattgcctaa 3840
ctcatgggct ctgcccttct gctcggtgcc ctccacgtga ggcggggcac ctgcatgcac 3900
tgggaggggg cggctggccc agccctcggg gcaggagccc cctctgccac acgctttgtg 3960
cctccaaagc tccccccgcc ttggtcaggg cctcagacca gccaaccttt gtggaataag 4020
ccccagccca gccaaaccaa acccagatgc ctgaggcctg gctggggctg cccccgcagg 4080
acactgtggc catgccacgg agggggcagt ggacaaaacc aatccaaagc caagccggga 4140
ctggctgcgg acccagcctc ctgtgccgcg cactcacgga gctgcgtagt ctcctcagac 4200
atagtcaaag ctttgccgag aaaagaaatg tatgaactat atttgacaac ataaaatctc 4260
tctatttttc accactggaa tttagtcaag cttcaggccc ctctgctcct gtctgtgtct 4320
tgcgtctgtg gccttcctat tgtgtcttgt gttttggtgg atgtgacagg gctggggcca 4380
cagtctactc tgtctctgct gctagagaag ccacctgtgg aggactgggc tgtggttggg 4440
cctgaggcct gtggaggagg tgagtgtagc cagcagcggc cgtctactcc tgttctggcc 4500
tgagaccacc ggtgtgggtc acgaggaccc tggcccacag tgttgagggt cctctctttc 4560
gggggctctc ctggggcctt cgatgggctt ttcttcttgt cagtggaggg agcagctccc 4620
cactcagccc tgggacaggc cctgggactg tggtggccgg tggccctggc ccagctctgg 4680
agtgcatgtg tgtgtgctca gatcccgcat ctatgcaaag gtgcaggctg cctgtgaggc 4740
tccaggcggt ggaggtgcgg cagctgctgc tcaggtgcca tgccctgaag aggcagggta 4800
cacatggggc tgggagggca aagatggggc ggggcctccc cctgagagag ctcaccctcc 4860
acagtgaccc ttttccttcc tgcctaatac ctcctcccgt tgggctgtga cttttcctcc 4920
tgccctcagc ctctgaaaca gaaatctttg gggcctcccc tttccccagc gtctggcaag 4980
agctgatgag gtcctgagga acagtgtccc caggaaccac cttctggagc ctagcggcca 5040
gacgtggctt ctcctgagtt ctagggctcg ggccagagtg gcactactgc ccggccagtc 5100
caggctcagg caggaatcgg acgctggggc ccgggctctg cacagagagc tgggcttgag 5160
tggagtttat tgtagatttc tcccaagggg atcacttagc ttctcactga cacacccttc 5220
ccaattgcca caagcgcagg ggtatcttac agcactttgg ggaggggtgg gacaaactgc 5280
aaggttctgg ggccaaggcc tacccagggg cctctgccca gagaactcac aaccccctct 5340
ctgacctagg ggacaatgca aacaggtcac agtgcattcc catattaggc catccccttc 5400
acgaagaatt caggggatgt gggaagtggg gaggcgggga gggatcttga ctcttgtctc 5460
ctttgtcctt ttgttcagac agagttgtac ctgcagcaga caactctgaa ttaaagcatg 5520
aaaacacagc 5530
<210> 118
<211> 411
<212> DNA
<213> 人类
<400> 118
atggcggggg ctggttccgc cgctgtatcg ggggcaggga ccccggtggc ggggcccaca 60
ggccgcgacc ttttcgccga agggctgctg gagttcctgc gacccgctgt gcagcagctc 120
gactctcacg tacacgccgt cagagagagc caggtagagc tccgggaaca aattgacaac 180
ctagccacag aactgtgccg cataaatgag gatcagaagg tggccctgga tcttgacccc 240
tatgttaaga agctacttaa tgcccggcga cgcgttgtct tggttaacaa cattctacag 300
aatgctcagg aacgactgag acggctaaac cacagtgttg ccaaggaaac agcccgcagg 360
agagcaatgc tggattcggg aatttacccc cctggctccc caggcaaata a 411
<210> 119
<211> 2490
<212> DNA
<213> 人类
<400> 119
agctcgcgcg cctgcaggtc gacactagtg gatccaaaga attcggcacg agggaagatg 60
gcgccgccgg tggcagagag ggggctaaag agcgtcgtgt ggcagaagat aaaagcaaca 120
gtgtttgatg actgcaagaa agaaggcgaa tggaagataa tgcttttaga tgaatttacc 180
actaagcttt tggcatcgtg ttgcaaaatg acagatcttc tagaagaagg tattactgtt 240
gtagagaata tttataagaa ccgtgaacct gtcagacaaa tgaaagctct ttatttcatc 300
actccgacat caaagtctgt agattgtttc ttacatgatt ttgcaagtaa atcggagaac 360
aagtataaag cagcatatat ttacttcact gacttttgcc ctgataatct ctttaacaaa 420
attaaggctt cttgctccaa gtcaataaga agatgtaaag aaataaatat ttccttcatt 480
ccacatgaat ctcaggtgta tactcttgat gtaccagatg cattctatta ctgttatagt 540
ccagaccctg gtaatgcaaa gggaaaagat gccattatgg aaacaatggc tgaccagata 600
gttacagtgt gtgccacctt ggatgaaaat cccggagtaa gatataaaag taaacctcta 660
gataatgcca gtaagcttgc acagcttgtt gaaaaaaagc ttgaagacta ctacaagatt 720
gatgaaaaga gcctaataaa gggtaaaact cattcacagc tcttaataat tgatcgtggc 780
tttgatcctg tgtccactgt cctgcatgaa ctgacctttc aggcaatggc atatgatcta 840
ctaccaattg agaatgatac atacaaatat aaaacagatg gaaaagaaaa ggaggccatc 900
cttgaagaag aagatgacct ctgggttaga attcgacatc gacatattgc ggttgtgtta 960
gaggaaattc ccaagcttat gaaagaaatt tcatcaacaa agaaagcaac agaaggaaag 1020
acatcactta gtgctcttac ccagctgatg aaaaagatgc cccatttccg aaaacagatt 1080
actaagcaag ttgtccatct taacttagca gaagattgca tgaataagtt caagcttaat 1140
atagaaaagc tctgcaaaac tgaacaggac ctggcacttg gaactgatgc agaaggacag 1200
aaggtgaaag attccatgcg agtactcctt ccagttctac tcaacaaaaa tcatgataat 1260
tgtgataaaa taagagcaat tctactttat atcttcagta ttaatggaac tacggaagaa 1320
aatttggaca ggttgatcca gaatgtaaag atagaaaatg agagtgacat gattcgtaac 1380
tggagttacc ttggtgttcc cattgttccc caatctcaac aaggcaaacc gttaagaaag 1440
gatcggtctg cagaagaaac ttttcagctc tctcggtgga caccttttat caaagatatt 1500
atggaggatg ctattgataa tagattagat tcaaaagaat ggccatattg ttcccagtgt 1560
ccagcagtat ggaatggttc aggagctgta agtgctcgcc agaaacccag agctaattat 1620
ttagaagacc gaaaaaatgg gtcaaagctg attgtttttg taattggagg gatcacatac 1680
tctgaagtgc gttgtgctta tgaagtttct caggcacata aatcctgtga agttattatt 1740
ggttctacac atgttttaac acccaaaaag ctgttggatg atataaagat gctgaataaa 1800
cccaaggata aagtctcctt aattaaagat gaatagcatt tctttttgga gggtttagag 1860
attcttacta atatgttgaa ctaaaataga aagaaaatgt tgctgtcatg taatttaaac 1920
aatgtaaata ttttatggaa taatggcttt tcaaatacat ttcttaagga actgtttatg 1980
attattactg gatttgtcat ttttgataat ttaaatattg ctgctgcttt gtagatgatg 2040
agaagaaatg ttaaagtgct ttctaaaagg aaattttttc acctttggag gagaatatat 2100
tagagttgtg ggtaattttt cacagccacc tatgtacata ctaattaccc attggatact 2160
tatatctaaa agtctcatgc tgaagtatag tttttgggaa agaatgattt taaataaaga 2220
gattgtaaaa gtaaaaaact gtaaatgtat atgtatgata gaattgtttc ctctaagtgt 2280
agtttttctt tcaactaaaa ttcagtttat gtgtaaaata attcagtcat taatagaaat 2340
ggagtgattt cacagtgtgt actgttttgc cacatacttc taaagaacac aattttatat 2400
aattttgaaa tcatgtatgt ttaaattaga aaaccaaaaa tcatgaacat tctaagagaa 2460
aataaatata gaatttaaaa aattaaaaaa 2490
<210> 120
<211> 980
<212> DNA
<213> 人类
<400> 120
gcacgagcaa agatggcggc agggaccagc agttactggg aagatctcag gaaacaggct 60
cgacagctgg aaaatgaact tgacctgaaa ctagtttcct tcagcaaact atgtacaagt 120
tacagtcata gcagtacccg agatggaaga cgcgacaggt atagttctga tacaacaccc 180
cttttaaatg gatcaagcca agacagaatg tttgagacaa tggcgattga gattgaacaa 240
cttttggcaa ggcttacagg ggtaaatgat aaaatggcag aatataccaa cagtgcaggt 300
gtcccctcct tgaatgcagc cctgatgcat acattacagc ggcatagaga catattgcag 360
gattatacac atgaattcca taaaaccaaa gcaaacttta tggcaatacg ggaaagggag 420
aatcttatgg gatcagtacg aaaagatatt gagtcatata aaagtgggtc tggagtaaac 480
aacagaagaa ctgagctatt tttgaaagaa catgaccacc ttcgaaactc agatcgtctg 540
atagaagaga caataagcat tgctatggca acaaaagaaa atatgacttc acagagagga 600
atgttgaagt caattcacag caaaatgaac actttggcca atcgttttcc tgctgtaaac 660
agcctgatcc agaggatcaa cctgaggaag cggcgggact cgctcatcct agggggtgtt 720
attgggatct gtaccatcct gttgctgctg tatgcgttcc attgatggga catcttcagg 780
gactcttgac agccaccgct ttcacaccct ggtctggaat aaggaaacat cggagggaga 840
agttgactgt cttgataatt agcctgacca gcaggatgaa tgcaagactg acagtgatgg 900
actctgtgac atggtcaggt tgagctgaag ccacagtttc tctgtgctgt gttttctaac 960
acatttttct gtttttaatt 980
<210> 121
<211> 864
<212> DNA
<213> 人类
<400> 121
atgaaagacc ggctagcaga acttctggac ttgtccaagc aatatgacca gcagttccca 60
gacggggacg atgagtttga ctcgccccac gaggacatcg tgttcgagac ggaccacatc 120
ctggagtccc tgtaccgaga catccgggac attcaggatg aaaaccagct gctggtggcc 180
aatgtgaagc ggctgggaaa gcagaacgcc cgcttcctca cgtccatgcg gcgcctcagc 240
agcatcaagc gcgacaccaa ctccatcgcc aaggccatca aggccccccc cgaggtcatc 300
cactgcaacg tgcgcgccat gaaggagctg agcgaggcgg ctgaggccca gcacggccca 360
gcactcggca gtggcggcat ttcgcgggcg cagtacaacg cgctcaccct caccttccag 420
cgcgccatgc acgactacaa ccaggccgag atgaagcagc gcgacaactg caagatccgc 480
atccagcgcc agctggagat catgggcaag gaagtctcgg gcgaccagat cgaggacatg 540
ttcgagcagg gtaagtggga cgtgttttcc gagaacttgc tggccgacgt gaagggtgtg 600
cgggccgccc tcaacgagat cgagagccgc caccgcgaac tcgtgcgcct ggagagcgcc 660
atccgcgacg tacacgagct cttcttgcag atggcggtgc tggtggagaa gcaggccgac 720
accctgaacg tcatcgagct caacgtacaa aagacggtcg actacaccgg ccaggccaag 780
gcgcaggtgc ggaaggccgt gcagtacgag gagaagaacc cctgccggac cctctgctgc 840
ttctgctgtc cctgcctcaa gtag 864
<210> 122
<211> 1507
<212> DNA
<213> 人类
<400> 122
ctcgaggcca cgaaggcccc gacaccatgt cctgccggga tcggacccag gagtttctgt 60
ctgcctgcaa gtcgctgcag acccgtcaga atggaatcca gacaaataag ccagctttgc 120
gtgctgtccg acaacgcagt gaattcaccc tcatggccaa gcgcattggg aaagacctta 180
gcaacacatt tgccaagctg gagaagctga caatcttggc aaagcgcaag tccctctttg 240
atgataaagc agtggaaatt gaagagctaa catatatcat caaacaggac atcaatagcc 300
tcaacaaaca aattgctcag ctccaggatt tcgtgagagc caagggcagc cagagtggcc 360
ggcacctgca gacccactcc aacaccattg tggtctcctt gcagtcgaaa ctggcttcta 420
tgtccaatga cttcaaatcg gttttagaag tgaggacaga gaacctgaag cagcagagga 480
gccggagaga gcagttctcc cgggcacctg tgtcagccct gccccttgcc cctaaccacc 540
tgggcggtgg tgctgtggtt ctgggggcag agtcccatgc ctccaaggat gtcgccatcg 600
acatgatgga ctctcggacc agccagcagc tgcagctcat tgacgagcag gattcctaca 660
tccagagtcg ggcagacacc atgcagaaca ttgagtcgac aattgttgag ttgggctcca 720
tctttcagca gttggcacac atggttaagg aacaggagga aaccattcag aggatcgacg 780
agaacgtgct aggagcccag ctggacgttg aggccgccca ttcagagatc ctcaagtact 840
tccagtctgt cacctccaac cggtggctca tggtcaaaat cttcctcatc ctcattgtct 900
tcttcatcat ctttgtggtc ttccttgctt gaaccctctc tactctgagg cactctgttg 960
gggtttggga ccctcctggg aaggcaagtg gccagtgctg ccactgagcc tgtgcagggt 1020
acttgggaga aaggccctgt ttccctggaa ctgctaagaa tgaccactgc ccctgatccc 1080
ccaccccttg cctctggcca ccctgtcctc cccccaccac cctcaggcct atgaaacaca 1140
cagggttcta gatttgaact ctgctgtgaa gtgactggaa gggagcagag gccagctggg 1200
ggccagtggg ggaggttgtt tccactagga gatttttata aaccctctcc agcctctccc 1260
ggaaaggaag cgttggcagc aaagggagat gatgccctta cccaccttcc tgtgagtgaa 1320
gagaggaagc agccccaggg accaattttc ccaattgacc tctttcttcc tctttcacca 1380
tgtgaggcag ggagccctga gcccttcagc tgcctgcaca acccctgaca ttggctgctg 1440
gtgactcaat ctgccaaatg tgctgcagct cgttttctcc caattacagc aagactgtca 1500
gcctcca 1507
<210> 123
<211> 1614
<212> DNA
<213> 人类
<400> 123
gagggagccg tggaggtcca ggtgactgct tagaaaactg cacagcatct gatgaaatta 60
gcgaataaga acatcaacca tgtcttacac tccaggagtt ggtggtgacc ccacccagtt 120
ggcccagagg atctcttcta acatccagaa gatcacacag tgttctgtgg aaatacaaag 180
aactctgaat caacttggaa cacctcaaga ttcacctgaa ttgaggcaac agttgcaaca 240
gaagcagcag tatactaacc agcttgccaa agaaacagat aagtacatta aagagtttgg 300
atctctgccc accaccccca gtgaacagcg tcaaaggaaa atacagaagg atcgcttagt 360
ggcagagttc acaacatcac tgacaaactt ccagaaggtc cagaggcagg ctgctgagcg 420
agagaaagag tttgttgctc gagtaagagc cagttccaga gtgtctggca gttttcctga 480
ggacagctca aaagaaagga atcttgtatc ctgggaaagc caaactcaac ctcaagtgca 540
ggtgcaggat gaagaaatta cagaggatga cctccgtctt attcatgaga gagaatcttc 600
tatcaggcaa cttgaagctg atattatgga tattaatgaa atatttaaag atttgggaat 660
gatgattcat gaacaaggag atgtaataga tagcatagaa gccaatgtgg aaaatgcaga 720
ggtgcacgtt cagcaagcaa atcagcagct gtcaagggca gcagattatc agcgcaaatc 780
cagaaaaacc ctgtgcatca tcattcttat ccttgtcatt ggagttgcga ttatcagtct 840
catcatatgg ggattgaacc actgaagtta taaaggagca cactgtcgca ctacattgtc 900
taaattatgt aggaagattc ctgtaatcat gtttttttaa ttattatttt aaagctattg 960
tataaaggat ggttcccata ctttgttatt tttattgggg gggttgggcg ggttcctttg 1020
gattaaatct gatattttct aatactgaaa gattttctaa atgtcactgc tgacataact 1080
cccttggtct tcaatttaat agttgttaag ttttgggcca cattgcatat gcctttcatt 1140
tataatttat ttaccctgct tgacttagtt tggggaattc ggaaatttaa ggtgtgtgta 1200
ttctgttggg atctccctgc cacgtgaaca caccaagatg tgtgttactt caagttaaaa 1260
ctccccaaaa tttaattttt gatttgcttc caccagggga aaatattctc caataatgta 1320
aaataattaa ggtccaatac atgggttgta tttttctggt tcacaacagc acaaagtgtc 1380
tttcattttt ttgttggatt tcctttaaga tcttttttac cctgaagtcg gtgaacactt 1440
ttctagttaa tttgatactc tttctgtgta tataataagc ttttgctgta gattgcctag 1500
taaaattact aaggataggt tgtttttaca tatggtctat ttaagtctga tgtttacggg 1560
ggagagtgta gttactaaaa atgtttaaca taatttggaa gaagagtatg aaca 1614
<210> 124
<211> 691
<212> DNA
<213> 人类
<400> 124
accaacggtc tccccctccc agcttcttac ctcggcttcc tactccttcc cccgcccgcc 60
cagcaccgcc agcccgggag agctgccggg agttccccgg gagcgctgcc gggagttccc 120
cgggagcctc aggtggtgac tatcctgttg agaagcaaaa gatactttgc aagtaaaaaa 180
tatgcctccc aagtttaagc gccacctcaa tgatgatgat gtcacaggtt ctgtgaaaag 240
tgaaaggaga aatcttttgg aagatgattc agatgaagaa gaggactttt ttctaagggg 300
accatctgga ccaagatttg gacctagaaa tgataaaatt aagcatgttc agaatcaagt 360
ggatgaagtt attgatgtca tgccagaaaa tattacaaag gtaattgaga gaggggagag 420
actagatgaa ctacaggaca aatcagaaag cttatcggat aatgcaacag cttttagcaa 480
cagatccaaa caacttcgaa ggcaaatgtg gtggcgtgga tgcaaaataa aagccatcat 540
ggctttggtt gctgctatcc ttttgctagt gattatcatt cttatagtca tgaaataccg 600
tacttgattt gatgacagag atcttcatta acaagatctg gacagtaata aagatgctgc 660
ataattaatg aactatgtgt atatacttca a 691
<210> 125
<211> 924
<212> DNA
<213> 人类
<400> 125
atggccacca ggcgtttaac cgacgctttc ttgttgttgc ggaataattc catccaaaac 60
cggcagctgt tagccgagca agagctggac gagcttgctg atgaccgtat ggcactggtg 120
tcaggcatca gcttagatcc agaagcagcg attggtgtga caaaacggcc acctcctaag 180
tgggtggatg gagtggatga aattcagtat gatgttggcc ggattaagca gaagatgaaa 240
gaattggcca gccttcatga caagcattta aacagaccca ccctggatga cagcagcgaa 300
gaggaacatg ccattgagat aactacccaa gagatcactc agctcttcca caggtgccag 360
cgtgccgtgc agccctgccg agccgggaaa gggcctgctc cgagcaggag gggcggctgc 420
ttgggaacgt ggtgcctcgt ggcgcaggcc ctgcaggaac tctccaccag cttccggcac 480
gcacaatcag gctacctcaa acgcatgaag aatcgagagg aaagatccca gcattttttc 540
gacacatcag taccactaat ggatgatgga gacgataaca ctctttacca tcggggtttt 600
acagaggacc agttagttct ggtggagcag aacacactga tggtggaaga gcgggaacga 660
gagattcgcc agattgtaca gtccatttct gacctgaatg aaatattcag ggacttaggg 720
gcgatgattg tagaacaggg tacagtcctt gacagaattg actataacgt tgaacagtcc 780
tgtatcaaaa ctgaagatgg tttgaaacag cttcacaagg cagaacagta tcaaaagaag 840
aatcggaaga tgcttgtgat tttaatatta tttgtcatca tcattgtgct cattgttgtc 900
ctcgttggcg tgaagtctcg ataa 924
<210> 126
<211> 750
<212> DNA
<213> 人类
<400> 126
atgtctctcg aagacccctt ttttgtagtc cgaggcgagg tgcagaaggc ggtgaacacg 60
gcccgcgggc tgtaccagcg ctggtgcgag ctcctgcagg aaagcgcggc ggtcggacgc 120
gaggagctgg actggacgac caatgagctg cggaatggcc tgcgcagcat cgagtgggac 180
ctcgaggacc tggaagagac catcggtata gtggaagcca acccaggcaa gttcaagctc 240
ccagccgggg acctgcagga gagaaaggtg ttcgtggagc ggatgcgaga ggcagtccag 300
gaaatgaagg accatatggt cagcccaaca gccgtagcat ttttggagag gaataacaga 360
gagatactcg caggcaagcc agctgcccag aagtcaccca gcgacctgct ggatgccagc 420
gcagtctcgg ccacatctcg ctacatcgag gagcagcagg ccacacagca gctgatcatg 480
gatgaacagg atcaacagct ggagatggtg tctgggagca tccaggttct gaagcacatg 540
tccggccgcg ttggagaaga gctggacgag cagggcatca tgctggatgc cttcgcccaa 600
gagatggacc acacccagtc ccgcatggac ggggtcctca ggaagttggc caaagtatcc 660
cacatgacga gtgaccgccg acagtggtgt gccatcgccg tgctagtggg ggtgcttctc 720
ctcgttctca tcttactatt ctctctctga 750
<210> 127
<211> 895
<212> DNA
<213> 人类
<400> 127
atgcgcgaca ggacccacga gctgagacag ggggatgaca gctcggacga agaggacaag 60
gagcgggtcg cgctggtggt gcacccgggc acggcacggc tggggagccc ggacgaggag 120
ttcttccaca aggtccggac aattcggcag actattgtca aactggggaa taaagtccag 180
gagttggaga aacagcaggt caccatcctg gccacgcccc ttcccgagga gagcatgaag 240
caggagctgc agaacctgcg cgatgagatc aaacagctgg ggagggagat ccgcctgcag 300
ctgaaggcca tagagcccca gaaggaggaa gctgatgaga actataactc cgtcaacaca 360
agaatgagaa aaacccagca tggggtcctg tcccagcaat tcgtggagct catcaacaag 420
tgcaattcaa tgcagtccga ataccgggag aagaacgtgg agcggattcg gaggcagctg 480
aagatcacca atgctgggat ggtgtctgat gaggagttgg agcagatgct ggacagtggg 540
caaagcgagg tgtttgtgtc caatatcctg aaggacacgc aggtgactcg acaggcctta 600
aatgagatct cggcccggca cagtgagatc cagcagcttg aacgcagtat tcgtgagctg 660
cacgacatat tcacttttct ggctaccgaa gtggagatgc agggggagat gatcaatcgg 720
attgagaaga acatcctgag ctcagcggac tacgtggaac gtgggcagga gcacgtcaag 780
acggccctgg agaaccagaa gaaggcgagg aagaagaaag tcttgattgc catctgtgtg 840
tccatcaccg tcgtcctcct agcagtcatc attggcgtca cagtggttgg ataas 895
<210> 128
<211> 639
<212> DNA
<213> 人类
<400> 128
atggatcccc tgttccagca aacgcacaag caggtccacg agatccagtc ttgcatggga 60
cgcctggaga cggcagacaa gcagtctgtg cacatagtag aaaacgaaat ccaagcaagc 120
atagaccaga tattcagccg tctagaacgt ctggagattt tgtccagcaa ggagccccct 180
aacaaaaggc aaaatgccag acttcgggtt gaccagttaa agtatgatgt ccagcacctg 240
cagactgcgc tcagaaactt ccagcatcgg cgccatgcaa gggagcagca ggagagacag 300
cgagaagagc ttctgtgtcg aacgttcacc actaacggct ctgacaccac cataccaatg 360
gacgaatcac tgcagtttaa ctcctccctc cagaaagttc acaacggcat ggatgacctc 420
attttagatg ggcacaatat tttagatgga ctgaggaccc agagactgac cttgaagggg 480
actcagaaga agatccctga cattgccaac atgctgggct tgtccaacac agtgatgcgg 540
ctcatcgaga agcgggcttt ccaggacaag tactttatga taggtgggat gctgctgacc 600
tgtgtggtca tgttcctcgt ggtgcagtac ctgacatga 639
<210> 129
<211> 1903
<212> DNA
<213> 人类
<400> 129
gggacgcgct acctgcctcc gggcgcctgg gcttcaggat gaaggaccgt ctggagcagc 60
tgaaggccaa gcagctgaca caggatgatg atactgatgc ggttgagatt gctatcgaca 120
acacggcttt tatggacgag ttcttttctg agattgagga aactcggctt aacattgaca 180
agatctcaga acatgtagag gaggctaaga aactctacag tatcattctc tctgcaccga 240
ttccagagcc aaaaaccaag gatgacctag agcagctcac gactgagatt aagaaaaggg 300
ccaacaacgt ccggaacaaa ctgaagagca tggagaagca tattgaagaa gatgaggtca 360
ggtcatcggc agaccttcgg attcggaaat cccagcactc tgtcctttct cggaagtttg 420
tggaggtgat gaccaaatac aatgaagctc aagtggactt ccgagaacgc agcaaagggc 480
gaatccagcg gcacgtcgaa attactggca aaaagacaac cgatgaggag ctggaggaga 540
tgttggagag tggcaacccg gccatcttca cttctgggat cattgactca cagatttcca 600
agcaagccct cagtgagatt gagggacgac acaaggacat tgtgaggctg gagagcagca 660
tcaaggagct tcacgacatg tttatggaca tcgccatgct ggtggagaat cagggtgaga 720
tgttagataa catagagttg aatgtcatgc acacagtgga ccacgtggag aaggcacgag 780
atgaaagcaa aaaagctgtg aaataccaga gtcaggcccg gaagaaattg ataattatca 840
ttgtgctagt agttgtgttg ctgggcattt tagcattgat tattggactt tccgttgggc 900
tgaattaaga gtggcctaag aggctgctgc actgaaataa actgatttca ctccagactg 960
gtgtggccac ccttgtcttc agatgagaat ggagtctgaa tggccttcct gagagcgagt 1020
gcgacccgtt cctttgtttc cttgcaacca cccttggacc tgactcagct aacaatctag 1080
ccctggggga atgtgatcta cctgatgcga ccctgagttc tccccagagc ctcctcctgc 1140
cccaccagct ctcaagtacc ttttctcctg gactgtgtgg acccacccag ctttcttcct 1200
ccctgttgtg tgtcagatta tgccttgcac ttgggaaagc tcttgtgaga ctctcccaag 1260
gtgctgtatt ttcctacctc aggagtattc tccagaaact gcaatgtatt tttttagggg 1320
agtatcttta acaaagcaga atgattcttc taagtttggc aacaagaagg cttggatctg 1380
agtcttctac ctggcaggat gccaatcctg tttgttgtcc gtatgtcctg aaaacatgag 1440
ggactggcag atgtcatttt ggtctaaaga gctgacttgt ttgaaattca gccttaaatt 1500
aagctcttag ttgttcagct tggggggcaa ctttgatttt tctctgtgtt gtagtctctc 1560
atatttactc aaggaggacc aggatgatac agtcatctga ggttatgctt tgcaaaaggc 1620
tgacggtatg gaatatgttt ccatgtctga gtcttagaaa ctggctgctc attgttagaa 1680
agtgatgctt tgtgagacta ttgtcttggg gccaaaaata atcagggatt ttaaattggg 1740
caagggagaa ggtgctagaa tcctaagctc tggaaatatt tcatgacact ggtgtttcac 1800
tcatgtgttc cagatgtatt ctaattgtgt atgaaatgta tgtacacata agtgtgtgtg 1860
tctcaggaag taggaaataa aaatggaagc tattatgacc tca 1903
<210> 130
<211> 1248
<212> DNA
<213> 人类
<400> 130
caagatatcg aattccaaat ttgagggcct cccggctctg gcgccggagg gagagctcag 60
gccgccatgc gcgacaggac ccacgagctg agacaggggg atgacagctc ggacgaagag 120
gacaaggagc gggtcgcgct ggtggtgcac ccgggcacgg cacggctggg gagcccggac 180
gaggagttct tccacaaggt ccggacaatt cgtcagacta ttgtcaaact ggggaataaa 240
gtccaggagt tggagaaaca gcaggtcacc atcctggcca cgccccttcc cgaggagagc 300
atgaagcagg agctgcagaa cctgcgcgat gagatcaaac agctggggag ggagatccgc 360
ctgcagctga aggccataga gccccagaag gaggaagctg atgagaacta taactccgtc 420
aacacaagaa tgagaaaaac ccagcatggg gtcctgtccc agcaattcgt ggagctcatc 480
aacaagtgca attcaatgca gtccgaatac cgggagaaga acgtggagcg gattcggagg 540
cagctgaaga tcaccaatgc tggcatggtg tctgatgagg agttggatca gatgctggac 600
agtgggcaaa gcgaggtgtt tgtgtccaat atccttaagg acacgcaggt gactcgacag 660
gccttaaatg agatctcggc ccggcacagt gagatccagc agcttgaacg cagtattcgt 720
gagctgcacg acatattcac ttttctggct accgaagtgg agatgcaggg ggagatgatc 780
aatcggattg agaagaacat cctgagctca gcggactacg tggaacgtgg gcaggagcac 840
gtcaagacgg ccctggagaa ccagaagaag gtgaggaaga agaaagtctt gattgccatc 900
tgtgtgtcca tcaccgtcgt cctcctagca gtcatcattg gcgtcacagt ggttggataa 960
tgtcgcacat tgttggcact aggagcacca ggaacccagg gcctggcctt ctctcccagc 1020
agcctggggg gcaggcagag cctccagtcg gaccccttcc tcacacactg gcccctatgc 1080
agaagggcag acagttcttc tggggttggc agctgctcat tcatgatggc ctcctccttc 1140
aggcctcaat gcctggggga ggcctgcact gtcctgattg gccgggacac acggttttgt 1200
aaaaaattaa aaaacaaaaa aagagcatag aaaaaaaaaa aaccgagt 1248
<210> 131
<211> 21
<212> DNA
<213> 褐家鼠
<400> 131
tttctccgcg tccgccatgg t 21
<210> 132
<211> 21
<212> DNA
<213> 褐家鼠
<400> 132
tttcctcgcg tcccgcatgg t 21
<210> 133
<211> 20
<212> DNA
<213> 褐家鼠
<400> 133
ggcaatccta caggttccag 20
<210> 134
<211> 277
<212> PRT
<213> 人类
<400> 134
Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu
1 5 10 15
Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala
20 25 30
Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Asp Ser Gln Lys
35 40 45
Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Ala Asp Phe Leu Gln
50 55 60
Asn Ile Leu Ala Gln Glu Asp Thr Ala Lys Gly Leu Asp Pro Leu Ala
65 70 75 80
Ser Glu Asp Thr Ser Arg Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp
85 90 95
Lys Glu Leu Lys Ala Thr Tyr Arg Glu His Val Glu Ala Ile Lys Ile
100 105 110
Gly Leu Thr Lys Ala Leu Thr Gln Met Glu Glu Ala Gln Arg Lys Arg
115 120 125
Thr Gln Leu Arg Glu Ala Phe Glu Gln Leu Gln Ala Lys Lys Gln Met
130 135 140
Ala Met Glu Lys Arg Arg Ala Val Gln Asn Gln Trp Gln Leu Gln Gln
145 150 155 160
Glu Lys His Leu Gln His Leu Ala Glu Val Ser Ala Glu Val Arg Glu
165 170 175
Arg Lys Thr Gly Thr Gln Gln Glu Leu Asp Gly Val Phe Gln Lys Leu
180 185 190
Gly Asn Leu Lys Gln Gln Ala Glu Gln Glu Arg Asp Lys Leu Gln Arg
195 200 205
Tyr Gln Thr Phe Leu Gln Leu Leu Tyr Thr Leu Gln Gly Lys Leu Leu
210 215 220
Phe Pro Glu Ala Glu Ala Glu Ala Glu Asn Leu Pro Asp Asp Lys Pro
225 230 235 240
Gln Gln Pro Thr Arg Pro Gln Glu Gln Ser Thr Gly Asp Thr Met Gly
245 250 255
Arg Asp Pro Gly Val Ser Phe Lys Ala Val Gly Leu Gln Pro Ala Gly
260 265 270
Asp Val Asn Leu Pro
275
<210> 135
<211> 277
<212> PRT
<213> 人类
<400> 135
Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu
1 5 10 15
Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala
20 25 30
Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Asp Ser Gln Lys
35 40 45
Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Ala Asp Phe Leu Gln
50 55 60
Asn Ile Leu Ala Gln Glu Asp Thr Ala Lys Gly Leu Asp Pro Leu Ala
65 70 75 80
Ser Glu Asp Thr Ser Arg Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp
85 90 95
Lys Glu Leu Lys Ala Thr Tyr Arg Glu His Val Glu Ala Ile Lys Ile
100 105 110
Gly Leu Thr Lys Ala Leu Thr Gln Met Glu Glu Ala Gln Arg Lys Arg
115 120 125
Thr Gln Leu Arg Glu Ala Phe Glu Gln Leu Gln Ala Lys Lys Gln Met
130 135 140
Ala Met Glu Lys Arg Arg Ala Val Gln Asn Gln Trp Gln Leu Gln Gln
145 150 155 160
Glu Lys His Leu Gln His Leu Ala Glu Val Ser Ala Glu Val Arg Glu
165 170 175
Arg Lys Thr Gly Thr Gln Gln Glu Leu Asp Arg Val Phe Gln Lys Leu
180 185 190
Gly Asn Leu Lys Gln Gln Ala Glu Gln Glu Arg Asp Lys Leu Gln Arg
195 200 205
Tyr Gln Thr Phe Leu Gln Leu Leu Tyr Thr Leu Gln Gly Lys Leu Leu
210 215 220
Phe Pro Glu Ala Glu Ala Glu Ala Glu Asn Leu Pro Asp Asp Lys Pro
225 230 235 240
Gln Gln Pro Thr Arg Pro Gln Glu Gln Ser Thr Gly Asp Thr Met Gly
245 250 255
Arg Asp Pro Gly Val Ser Phe Lys Ala Val Gly Leu Gln Pro Ala Gly
260 265 270
Asp Val Asn Leu Pro
275
<210> 136
<211> 277
<212> PRT
<213> 人类
<400> 136
Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu
1 5 10 15
Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala
20 25 30
Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Asp Ser Gln Lys
35 40 45
Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Ala Asp Phe Leu Gln
50 55 60
Asn Ile Leu Ala Gln Glu Asp Thr Ala Lys Gly Leu Asp Pro Leu Ala
65 70 75 80
Ser Glu Asp Thr Ser Arg Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp
85 90 95
Lys Glu Leu Lys Ala Thr Tyr Arg Glu His Val Glu Ala Ile Lys Ile
100 105 110
Gly Leu Thr Lys Ala Leu Thr Gln Met Glu Glu Ala Gln Arg Lys Arg
115 120 125
Thr Gln Leu Arg Glu Ala Phe Glu Gln Leu Gln Ala Lys Lys Gln Met
130 135 140
Ala Met Glu Lys Arg Arg Ala Val Gln Asn Gln Trp Gln Leu Gln Gln
145 150 155 160
Glu Lys His Leu Gln His Leu Ala Glu Val Ser Ala Glu Val Arg Glu
165 170 175
Arg Lys Thr Gly Thr Gln Gln Glu Leu Asp Arg Val Phe Gln Lys Leu
180 185 190
Gly Asn Leu Lys Gln Gln Ala Glu Gln Glu Arg Asp Lys Leu Gln Arg
195 200 205
Tyr Gln Thr Phe Leu Gln Leu Leu Tyr Thr Leu Gln Gly Lys Leu Leu
210 215 220
Phe Pro Glu Ala Glu Ala Glu Ala Glu Asn Leu Pro Asp Asp Lys Pro
225 230 235 240
Gln Gln Pro Thr Arg Pro Gln Glu Gln Ser Thr Gly Asp Thr Met Gly
245 250 255
Arg Asp Pro Gly Val Ser Phe Lys Ala Val Gly Leu Gln Pro Ala Gly
260 265 270
Asp Val Asn Leu Pro
275
<210> 137
<211> 230
<212> PRT
<213> 人类
<400> 137
Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu
1 5 10 15
Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala
20 25 30
Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Asp Ser Gln Lys
35 40 45
Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Ala Asp Phe Leu Gln
50 55 60
Asn Ile Leu Ala Gln Glu Asp Thr Ala Lys Gly Leu Asp Pro Leu Ala
65 70 75 80
Ser Glu Asp Thr Ser Arg Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp
85 90 95
Lys Glu Leu Lys Ala Thr Tyr Arg Glu His Val Glu Ala Ile Lys Ile
100 105 110
Gly Leu Thr Lys Ala Leu Thr Gln Met Glu Glu Ala Gln Arg Lys Arg
115 120 125
Thr Gln Leu Arg Glu Ala Phe Glu Gln Leu Gln Ala Lys Lys Gln Met
130 135 140
Ala Met Glu Lys Arg Arg Ala Val Gln Asn Gln Trp Gln Leu Gln Gln
145 150 155 160
Glu Lys His Leu Gln His Leu Ala Glu Val Ser Ala Glu Gly Lys Leu
165 170 175
Leu Phe Pro Glu Ala Glu Ala Glu Ala Glu Asn Leu Pro Asp Asp Lys
180 185 190
Pro Gln Gln Pro Thr Arg Pro Gln Glu Gln Ser Thr Gly Asp Thr Met
195 200 205
Gly Arg Asp Pro Gly Val Ser Phe Lys Ala Val Gly Leu Gln Pro Ala
210 215 220
Gly Asp Val Asn Leu Pro
225 230
<210> 138
<211> 277
<212> PRT
<213> 人类
<400> 138
Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu
1 5 10 15
Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala
20 25 30
Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Asp Ser Gln Lys
35 40 45
Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Ala Asp Phe Leu Gln
50 55 60
Asn Ile Leu Ala Gln Glu Asp Thr Ala Lys Gly Leu Asp Pro Leu Ala
65 70 75 80
Ser Glu Asp Thr Ser Arg Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp
85 90 95
Lys Glu Leu Lys Ala Thr Tyr Arg Glu His Val Glu Ala Ile Lys Ile
100 105 110
Gly Leu Thr Lys Ala Leu Thr Gln Met Glu Glu Ala Gln Arg Lys Arg
115 120 125
Thr Gln Leu Arg Glu Ala Phe Glu Gln Leu Gln Ala Lys Lys Gln Met
130 135 140
Ala Met Glu Lys Arg Arg Ala Val Gln Asn Gln Trp Gln Leu Gln Gln
145 150 155 160
Glu Lys His Leu Gln His Leu Ala Glu Val Ser Ala Glu Val Arg Glu
165 170 175
Arg Lys Thr Gly Thr Gln Gln Glu Leu Asp Gly Val Phe Gln Lys Leu
180 185 190
Gly Asn Leu Lys Gln Gln Ala Glu Gln Glu Arg Asp Lys Leu Gln Arg
195 200 205
Tyr Gln Thr Phe Leu Gln Leu Leu Tyr Thr Leu Gln Gly Lys Leu Leu
210 215 220
Phe Pro Glu Ala Glu Ala Glu Ala Glu Asn Leu Pro Asp Asp Lys Pro
225 230 235 240
Gln Gln Pro Thr Arg Pro Gln Glu Gln Ser Thr Gly Asp Thr Met Gly
245 250 255
Arg Asp Pro Gly Val Ser Phe Lys Ala Val Gly Leu Gln Pro Ala Gly
260 265 270
Asp Val Asn Leu Pro
275
<210> 139
<211> 277
<212> PRT
<213> 人类
<400> 139
Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu
1 5 10 15
Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala
20 25 30
Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Asp Ser Gln Lys
35 40 45
Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Ala Asp Phe Leu Gln
50 55 60
Asn Ile Leu Ala Gln Glu Asp Thr Ala Lys Gly Leu Asp Pro Leu Ala
65 70 75 80
Ser Glu Asp Thr Ser Arg Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp
85 90 95
Lys Glu Leu Lys Ala Thr Tyr Arg Glu His Val Glu Ala Ile Lys Ile
100 105 110
Gly Leu Thr Lys Ala Leu Thr Gln Met Glu Glu Ala Gln Arg Lys Arg
115 120 125
Thr Gln Leu Arg Glu Ala Phe Glu Gln Leu Gln Ala Lys Lys Gln Met
130 135 140
Ala Met Glu Lys Arg Arg Ala Val Gln Asn Gln Trp Gln Leu Gln Gln
145 150 155 160
Glu Lys His Leu Gln His Leu Ala Glu Val Ser Ala Glu Val Arg Glu
165 170 175
Arg Lys Thr Gly Thr Gln Gln Glu Leu Asp Gly Val Phe Gln Lys Leu
180 185 190
Gly Asn Leu Lys Gln Gln Ala Glu Gln Glu Arg Asp Lys Leu Gln Arg
195 200 205
Tyr Gln Thr Phe Leu Gln Leu Leu Tyr Thr Leu Gln Gly Lys Leu Leu
210 215 220
Phe Pro Glu Ala Glu Ala Glu Ala Glu Asn Leu Pro Asp Asp Lys Pro
225 230 235 240
Gln Gln Pro Thr Arg Pro Gln Glu Gln Ser Thr Gly Asp Thr Met Gly
245 250 255
Arg Asp Pro Gly Val Ser Phe Lys Ala Val Gly Leu Gln Pro Ala Gly
260 265 270
Asp Val Asn Leu Pro
275
<210> 140
<211> 230
<212> PRT
<213> 大猩猩
<400> 140
Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu
1 5 10 15
Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala
20 25 30
Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Asp Ser Gln Lys
35 40 45
Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Ala Asp Phe Leu Gln
50 55 60
Asn Ile Leu Ala Gln Glu Asp Thr Ala Lys Gly Leu Asp Pro Leu Ala
65 70 75 80
Ser Glu Asp Thr Ser Arg Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp
85 90 95
Lys Glu Leu Lys Ala Thr Tyr Arg Glu His Val Glu Ala Ile Lys Ile
100 105 110
Gly Leu Thr Lys Ala Leu Thr Gln Met Glu Glu Ala Gln Arg Lys Arg
115 120 125
Thr Gln Leu Gln Glu Ala Phe Glu Gln Leu Gln Ala Lys Lys Gln Met
130 135 140
Ala Met Glu Lys Arg Arg Ala Val Gln Asn Gln Trp Gln Leu Gln Gln
145 150 155 160
Glu Lys His Leu Gln His Leu Ala Glu Val Ser Ala Glu Gly Lys Leu
165 170 175
Leu Phe Pro Glu Ala Glu Ala Glu Ala Glu Asn Leu Pro Asp Asp Lys
180 185 190
Pro Gln Gln Pro Thr Arg Pro Gln Glu Gln Ser Thr Gly Asp Thr Met
195 200 205
Gly Arg Asp Pro Gly Val Ser Phe Lys Ala Val Gly Leu Gln Pro Ala
210 215 220
Gly Asp Ala Asn Leu Pro
225 230
<210> 141
<211> 281
<212> PRT
<213> 大猩猩
<400> 141
Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu
1 5 10 15
Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala
20 25 30
Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Asp Ser Gln Lys
35 40 45
Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Ala Asp Phe Leu Gln
50 55 60
Asn Ile Leu Ala Gln Glu Asp Thr Ala Lys Gly Leu Asp Pro Leu Ala
65 70 75 80
Ser Glu Asp Thr Ser Arg Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp
85 90 95
Lys Glu Leu Lys Ala Thr Tyr Arg Glu His Val Glu Ala Ile Lys Ile
100 105 110
Gly Leu Thr Lys Ala Leu Thr Gln Met Glu Glu Ala Gln Arg Lys Arg
115 120 125
Thr Gln Leu Gln Glu Ala Phe Glu Gln Leu Gln Ala Lys Lys Gln Met
130 135 140
Ala Met Glu Lys Arg Arg Ala Val Gln Asn Gln Trp Gln Leu Gln Gln
145 150 155 160
Glu Lys His Leu Gln His Leu Ala Glu Val Ser Ala Glu Val Arg Glu
165 170 175
Arg Lys Thr Gly Thr Gln Gln Ala Leu Glu Gly Val Phe Gln Lys Leu
180 185 190
Gly Asn Leu Lys Gln Gln Ala Glu Gln Glu Arg Asp Lys Leu Gln Arg
195 200 205
Val Ser Cys Cys Ser Leu Arg Leu Arg Leu Arg Gln Arg Ile Phe Gln
210 215 220
Met Ile Asn Pro Ser Ser Arg Leu Asp Pro Arg Ser Arg Val Gln Glu
225 230 235 240
Thr Pro Trp Gly Glu Thr Leu Val Cys Pro Ser Arg Leu Ser Val Tyr
245 250 255
Asn Leu Leu Glu Met Gln Ile Cys His Asp Phe Leu Glu Asp Ser Ser
260 265 270
Met Glu Lys Asp Pro Arg Lys Gly Leu
275 280
<210> 142
<211> 277
<212> PRT
<213> 大猩猩
<400> 142
Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu
1 5 10 15
Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala
20 25 30
Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Asp Ser Gln Lys
35 40 45
Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Ala Asp Phe Leu Gln
50 55 60
Asn Ile Leu Ala Gln Glu Asp Thr Ala Lys Gly Leu Asp Pro Leu Ala
65 70 75 80
Ser Glu Asp Thr Ser Arg Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp
85 90 95
Lys Glu Leu Lys Ala Thr Tyr Arg Glu His Val Glu Ala Ile Lys Ile
100 105 110
Gly Leu Thr Lys Ala Leu Thr Gln Met Glu Glu Ala Gln Arg Lys Arg
115 120 125
Thr Gln Leu Gln Glu Ala Phe Glu Gln Leu Gln Ala Lys Lys Gln Met
130 135 140
Ala Met Glu Lys Arg Arg Ala Val Gln Asn Gln Trp Gln Leu Gln Gln
145 150 155 160
Glu Lys His Leu Gln His Leu Ala Glu Val Ser Ala Glu Val Arg Glu
165 170 175
Arg Lys Thr Gly Thr Gln Gln Ala Leu Glu Gly Val Phe Gln Lys Leu
180 185 190
Gly Asn Leu Lys Gln Gln Ala Glu Gln Glu Arg Asp Lys Leu Gln Arg
195 200 205
Tyr Gln Thr Phe Leu Gln Leu Leu Tyr Thr Leu Gln Gly Lys Leu Leu
210 215 220
Phe Pro Glu Ala Glu Ala Glu Ala Glu Asn Leu Pro Asp Asp Lys Pro
225 230 235 240
Gln Gln Pro Thr Arg Pro Gln Glu Gln Ser Thr Gly Asp Thr Met Gly
245 250 255
Arg Asp Pro Gly Val Ser Phe Lys Ala Val Gly Leu Gln Pro Ala Gly
260 265 270
Asp Ala Asn Leu Pro
275
<210> 143
<211> 266
<212> PRT
<213> 褐家鼠
<400> 143
Met Ala Asp Ala Glu Lys Asn Ala Val Ala Glu Lys Asn Ala Val Ala
1 5 10 15
Glu Glu Asn Ala Val Ala Glu Glu Asn Ala Val Ala Asp Lys Asn Ala
20 25 30
Thr Lys Glu Val Leu Ala Glu Ala Ala Ser Val Leu Glu Pro Val Gly
35 40 45
Leu Pro Glu Glu Ala Glu Leu Pro Ala Lys Ile Met Glu Glu Phe Met
50 55 60
Arg Asn Ser Arg Lys Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val
65 70 75 80
Val Asn Phe Leu Gln Thr Phe Leu Ala Gln Glu Asp Asn Thr Asp Gln
85 90 95
Asn Pro Asp Ala Leu Ala Ser Glu Asp Thr Ser Arg Gln Lys Ala Thr
100 105 110
Glu Thr Lys Glu Gln Trp Lys Glu Leu Lys Ala Thr Tyr Met Asp His
115 120 125
Val Asp Val Ile Lys Cys Ala Leu Ser Glu Ala Leu Pro Gln Val Lys
130 135 140
Glu Ala His Arg Lys Tyr Thr Glu Leu Gln Lys Ala Phe Glu Gln Leu
145 150 155 160
Glu Ala Lys Lys Arg Val Leu Glu Glu Lys Leu Gln Leu Ala Gln Lys
165 170 175
Gln Trp Val Leu Gln Gln Lys Arg Leu Gln Asn Leu Thr Lys Ile Ser
180 185 190
Ala Glu Val Lys Arg Arg Arg Lys Arg Ala Leu Glu Lys Leu Asp Gly
195 200 205
Ser His Gln Glu Leu Glu Thr Leu Lys Gln Gln Ala Gly Gln Glu Gln
210 215 220
Glu Lys Leu Gln Arg Asn Gln Ser Tyr Leu Gln Leu Leu Cys Ser Leu
225 230 235 240
Gln Asn Lys Leu Val Ile Ser Glu Ser Lys Ala Asp Asp Lys Asp Val
245 250 255
Lys Gly Pro Ala Leu Pro Pro Lys Ser Pro
260 265
<210> 144
<211> 266
<212> PRT
<213> 褐家鼠
<400> 144
Met Ala Asp Ala Glu Lys Asn Ala Val Ala Glu Lys Asn Ala Val Ala
1 5 10 15
Glu Glu Asn Ala Val Ala Glu Glu Asn Ala Val Ala Asp Lys Asn Ala
20 25 30
Thr Lys Glu Val Leu Ala Glu Ala Ala Ser Val Leu Glu Pro Val Gly
35 40 45
Leu Pro Glu Glu Ala Glu Leu Pro Ala Lys Ile Met Glu Glu Phe Met
50 55 60
Arg Asn Ser Arg Lys Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val
65 70 75 80
Val Asn Phe Leu Gln Thr Phe Leu Ala Gln Glu Asp Asn Thr Asp Gln
85 90 95
Asn Pro Asp Ala Leu Ala Ser Glu Asp Thr Ser Arg Gln Lys Ala Thr
100 105 110
Glu Thr Lys Glu Gln Trp Lys Glu Leu Lys Ala Thr Tyr Met Asp His
115 120 125
Val Asp Val Ile Lys Cys Ala Leu Ser Glu Ala Leu Pro Gln Val Lys
130 135 140
Glu Ala His Arg Lys Tyr Thr Glu Leu Gln Lys Ala Phe Glu Gln Leu
145 150 155 160
Glu Ala Lys Lys Arg Val Leu Glu Glu Lys Leu Gln Leu Ala Gln Lys
165 170 175
Gln Trp Val Leu Gln Gln Lys Arg Leu Gln Asn Leu Thr Lys Ile Ser
180 185 190
Ala Glu Val Lys Arg Arg Arg Lys Arg Ala Leu Glu Lys Leu Asp Gly
195 200 205
Ser His Gln Glu Leu Glu Thr Leu Lys Gln Gln Ala Gly Gln Glu Gln
210 215 220
Glu Lys Leu Gln Arg Asn Gln Ser Tyr Leu Gln Leu Leu Cys Ser Leu
225 230 235 240
Gln Asn Lys Leu Val Ile Ser Glu Ser Lys Ala Asp Asp Lys Asp Val
245 250 255
Lys Gly Pro Ala Leu Pro Pro Lys Ser Pro
260 265
<210> 145
<211> 266
<212> PRT
<213> 褐家鼠
<400> 145
Met Ala Asp Ala Glu Lys Asn Ala Val Ala Glu Lys Asn Ala Val Ala
1 5 10 15
Glu Glu Asn Ala Val Ala Glu Glu Asn Ala Val Ala Asp Lys Asn Ala
20 25 30
Thr Lys Glu Val Leu Ala Glu Ala Ala Ser Val Leu Glu Pro Val Gly
35 40 45
Leu Pro Glu Glu Ala Glu Leu Pro Ala Lys Ile Met Glu Glu Phe Met
50 55 60
Arg Asn Ser Arg Lys Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val
65 70 75 80
Val Asn Phe Leu Gln Thr Phe Leu Ala Gln Glu Asp Asn Thr Asp Gln
85 90 95
Asn Pro Asp Ala Leu Ala Ser Glu Asp Thr Ser Arg Gln Lys Ala Thr
100 105 110
Glu Thr Lys Glu Gln Trp Lys Glu Leu Lys Ala Thr Tyr Met Asp His
115 120 125
Val Asp Val Ile Lys Cys Ala Leu Ser Glu Ala Leu Pro Gln Val Lys
130 135 140
Glu Ala His Arg Lys Tyr Thr Glu Leu Gln Lys Ala Phe Glu Gln Leu
145 150 155 160
Glu Ala Lys Lys Arg Val Leu Glu Glu Lys Leu Gln Leu Ala Gln Lys
165 170 175
Gln Trp Val Leu Gln Gln Lys Arg Leu Gln Asn Leu Thr Lys Ile Ser
180 185 190
Ala Glu Val Lys Arg Arg Arg Lys Arg Ala Leu Glu Lys Leu Asp Gly
195 200 205
Ser His Gln Glu Leu Glu Thr Leu Lys Gln Gln Ala Gly Gln Glu Gln
210 215 220
Glu Lys Leu Gln Arg Asn Gln Ser Tyr Leu Gln Leu Leu Cys Ser Leu
225 230 235 240
Gln Asn Lys Leu Val Ile Ser Glu Ser Lys Ala Asp Asp Lys Asp Val
245 250 255
Lys Gly Pro Ala Leu Pro Pro Lys Ser Pro
260 265
<210> 146
<211> 252
<212> PRT
<213> 小家鼠
<400> 146
Met Ala Asp Ala Glu Lys Asn Ala Val Ala Glu Lys Asn Asn Ala Val
1 5 10 15
Ala Thr Lys Glu Val Leu Ala Glu Ala Ala Ala Ile Leu Glu Pro Val
20 25 30
Gly Leu Gln Glu Glu Ala Glu Leu Pro Ala Lys Ile Met Glu Glu Phe
35 40 45
Met Arg Asn Ser Arg Lys Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln
50 55 60
Val Val Asn Phe Leu Gln Thr Phe Leu Ala Gln Glu Asp Thr Glu Gln
65 70 75 80
Ser Pro Asp Ala Leu Ala Ser Glu Asp Ala Ser Arg Gln Lys Ala Thr
85 90 95
Glu Thr Lys Glu Gln Trp Lys Asp Met Lys Ala Thr Tyr Met Asp His
100 105 110
Val Asp Val Ile Lys Cys Ala Leu Ser Glu Ala Leu Pro Gln Val Lys
115 120 125
Glu Ala His Arg Lys Tyr Thr Glu Leu Gln Lys Ala Phe Glu Gln Leu
130 135 140
Glu Ala Lys Lys Arg Val Leu Glu Glu Lys Leu Gln Leu Ala Gln Lys
145 150 155 160
Gln Trp Val Leu Gln Gln Lys Arg Leu Gln Asn Leu Thr Lys Ile Ser
165 170 175
Ala Glu Val Lys Arg Arg Arg Lys Arg Ala Leu Glu Lys Leu Asp Gly
180 185 190
Ser His Gln Glu Leu Glu Thr Leu Lys Gln Gln Ala Gly Gln Glu Gln
195 200 205
Glu Lys Leu Gln Arg Asn Gln Ser Tyr Leu Gln Leu Leu Cys Ser Leu
210 215 220
Gln Asn Lys Leu Val Ile Ser Glu Gly Lys Ala Glu Asp Lys Asp Val
225 230 235 240
Lys Gly Arg Ala Leu Thr Ala Lys Ser Lys Ser Pro
245 250
<210> 147
<211> 252
<212> PRT
<213> 小家鼠
<400> 147
Met Ala Asp Ala Glu Lys Asn Ala Val Ala Glu Lys Asn Asn Ala Val
1 5 10 15
Ala Thr Lys Glu Val Leu Ala Glu Ala Ala Ala Ile Leu Glu Pro Val
20 25 30
Gly Leu Gln Glu Glu Ala Glu Leu Pro Ala Lys Ile Met Glu Glu Phe
35 40 45
Met Arg Asn Ser Arg Lys Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln
50 55 60
Val Val Asn Phe Leu Gln Thr Phe Leu Ala Gln Glu Asp Thr Glu Gln
65 70 75 80
Ser Pro Asp Ala Leu Ala Ser Glu Asp Ala Ser Arg Gln Lys Ala Thr
85 90 95
Glu Thr Lys Glu Gln Trp Lys Asp Met Lys Ala Thr Tyr Met Asp His
100 105 110
Val Asp Val Ile Lys Cys Ala Leu Ser Glu Ala Leu Pro Gln Val Lys
115 120 125
Glu Ala His Arg Lys Tyr Thr Glu Leu Gln Lys Ala Phe Glu Gln Leu
130 135 140
Glu Ala Lys Lys Arg Val Leu Glu Glu Lys Leu Gln Leu Ala Gln Lys
145 150 155 160
Gln Trp Val Leu Gln Gln Lys Arg Leu Gln Asn Leu Thr Lys Ile Ser
165 170 175
Ala Glu Val Lys Arg Arg Arg Lys Arg Ala Leu Glu Lys Leu Asp Gly
180 185 190
Ser His Gln Glu Leu Glu Thr Leu Lys Gln Gln Ala Gly Gln Glu Gln
195 200 205
Glu Lys Leu Gln Arg Asn Gln Ser Tyr Leu Gln Leu Leu Cys Ser Leu
210 215 220
Gln Asn Lys Leu Val Ile Ser Glu Gly Lys Ala Glu Asp Lys Asp Val
225 230 235 240
Lys Gly Arg Ala Leu Thr Ala Lys Ser Lys Ser Pro
245 250
<210> 148
<211> 252
<212> PRT
<213> 小家鼠
<400> 148
Met Ala Asp Ala Glu Lys Asn Ala Val Ala Glu Lys Asn Asn Ala Val
1 5 10 15
Ala Thr Lys Glu Val Leu Ala Glu Ala Ala Ala Ile Leu Glu Pro Val
20 25 30
Gly Leu Gln Glu Glu Ala Glu Leu Pro Ala Lys Ile Met Glu Glu Phe
35 40 45
Met Arg Asn Ser Arg Lys Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln
50 55 60
Val Val Asn Phe Leu Gln Thr Phe Leu Ala Gln Glu Asp Thr Glu Gln
65 70 75 80
Ser Pro Asp Ala Leu Ala Ser Glu Asp Ala Ser Arg Gln Lys Ala Thr
85 90 95
Glu Thr Lys Glu Gln Trp Lys Asp Met Lys Ala Thr Tyr Met Asp His
100 105 110
Val Asp Val Ile Lys Cys Ala Leu Ser Glu Ala Leu Pro Gln Val Lys
115 120 125
Glu Ala His Arg Lys Tyr Thr Glu Leu Gln Lys Ala Phe Glu Gln Leu
130 135 140
Glu Ala Lys Lys Arg Val Leu Glu Glu Lys Leu Gln Leu Ala Gln Lys
145 150 155 160
Gln Trp Val Leu Gln Gln Lys Arg Leu Gln Asn Leu Thr Lys Ile Ser
165 170 175
Ala Glu Val Lys Arg Arg Arg Lys Arg Ala Leu Glu Lys Leu Asp Gly
180 185 190
Ser His Gln Glu Leu Glu Thr Leu Lys Gln Gln Ala Gly Gln Glu Gln
195 200 205
Glu Lys Leu Gln Arg Asn Gln Ser Tyr Leu Gln Leu Leu Cys Ser Leu
210 215 220
Gln Asn Lys Leu Val Ile Ser Glu Gly Lys Ala Glu Asp Lys Asp Val
225 230 235 240
Lys Gly Arg Ala Leu Thr Ala Lys Ser Lys Ser Pro
245 250
<210> 149
<211> 252
<212> PRT
<213> 小家鼠
<400> 149
Met Ala Asp Ala Glu Lys Asn Ala Val Ala Glu Lys Asn Asn Ala Val
1 5 10 15
Ala Thr Lys Glu Val Leu Ala Glu Ala Ala Ala Ile Leu Glu Pro Val
20 25 30
Gly Leu Gln Glu Glu Ala Glu Leu Pro Ala Lys Ile Met Glu Glu Phe
35 40 45
Met Arg Asn Ser Arg Lys Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln
50 55 60
Val Val Asn Phe Leu Gln Thr Phe Leu Ala Gln Glu Asp Thr Glu Gln
65 70 75 80
Ser Pro Asp Ala Leu Ala Ser Glu Asp Ala Ser Arg Gln Lys Ala Thr
85 90 95
Glu Thr Lys Glu Gln Trp Lys Asp Met Lys Ala Thr Tyr Met Asp His
100 105 110
Val Asp Val Ile Lys Cys Ala Leu Ser Glu Ala Leu Pro Gln Val Lys
115 120 125
Glu Ala His Arg Lys Tyr Thr Glu Leu Gln Lys Ala Phe Glu Gln Leu
130 135 140
Glu Ala Lys Lys Arg Val Leu Glu Glu Lys Leu Gln Leu Ala Gln Lys
145 150 155 160
Gln Trp Val Leu Gln Gln Lys Arg Leu Gln Asn Leu Thr Lys Ile Ser
165 170 175
Ala Glu Val Lys Arg Arg Arg Lys Arg Ala Leu Glu Lys Leu Asp Gly
180 185 190
Ser His Gln Glu Leu Glu Thr Leu Lys Gln Gln Ala Gly Gln Glu Gln
195 200 205
Glu Lys Leu Gln Arg Asn Gln Ser Tyr Leu Gln Leu Leu Cys Ser Leu
210 215 220
Gln Asn Lys Leu Val Ile Ser Glu Gly Lys Ala Glu Asp Lys Asp Val
225 230 235 240
Lys Gly Arg Ala Leu Thr Ala Lys Ser Lys Ser Pro
245 250
<210> 150
<211> 286
<212> PRT
<213> 牛
<400> 150
Met Gly Ala Ala Glu Ser Glu Val Glu Thr Ala Ala Arg Glu Val Leu
1 5 10 15
Ala Lys Val Ala Asp Ile Gln Glu Pro Val Gly Phe Gln Glu Glu Ala
20 25 30
Glu Leu Pro Ala Gln Ile Leu Ala Glu Phe Val Met Asp Ser Arg Lys
35 40 45
Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Val Asp Phe Leu Gln
50 55 60
Asn Phe Leu Val Gln Glu Gly Thr Ala Gln Asp Gln Asn Pro Leu Ala
65 70 75 80
Ser Glu Asp Thr Ser Arg Gln Lys Ala Leu Glu Ala Lys Glu Gln Trp
85 90 95
Lys Glu Leu Lys Ala Thr Tyr Gln Glu His Val Glu Val Ile Thr Asn
100 105 110
Ser Leu Thr Glu Ala Leu Pro Lys Val Glu Glu Ala Gln Ile Lys Gln
115 120 125
Ala Gln Leu Gln Glu Ala Leu Lys Gln Leu Gln Ala Lys Lys Gln Met
130 135 140
Ala Met Glu Lys Leu Arg Ile Ala Gln Lys Gln Trp Gln Leu Glu Gln
145 150 155 160
Glu Lys His Leu Gln Asn Leu Ala Glu Ala Ser Ser Glu Val Arg Glu
165 170 175
Arg Gln Thr Gly Ala Gln Gln Glu Leu Gln Arg Leu Tyr Gln Glu Leu
180 185 190
Gly Thr Leu Lys Gln Gln Ala Gly Gln Glu Lys Asp Lys Leu Gln Arg
195 200 205
His Gln Thr Phe Leu Gln Leu Leu Tyr Thr Leu Gln Gly Lys Gln Leu
210 215 220
Phe Asn Glu Ala Glu Ala Glu Ile Pro Gln Glu Leu Asp Leu Pro Lys
225 230 235 240
Asp Lys Leu Gln Gln Val Thr Gln Pro Gln Glu Gln Asn Thr Gln Asp
245 250 255
Thr Met Gly Arg Glu Ala Asp Asn Pro Gln Pro Val Gly Asp Ala Gly
260 265 270
Leu Pro Trp Leu Pro Gly Arg Gln Gln His Lys Glu Glu Ser
275 280 285
<210> 151
<211> 286
<212> PRT
<213> 牛
<400> 151
Met Gly Ala Ala Glu Ser Glu Val Glu Thr Ala Ala Arg Glu Val Leu
1 5 10 15
Ala Lys Val Ala Asp Ile Gln Glu Pro Val Gly Phe Gln Glu Glu Ala
20 25 30
Glu Leu Pro Ala Gln Ile Leu Ala Glu Phe Val Met Asp Ser Arg Lys
35 40 45
Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Val Asp Phe Leu Gln
50 55 60
Asn Phe Leu Val Gln Glu Gly Thr Ala Gln Asp Gln Asn Pro Leu Ala
65 70 75 80
Ser Glu Asp Thr Ser Arg Gln Lys Ala Leu Glu Ala Lys Glu Gln Trp
85 90 95
Lys Glu Leu Lys Ala Thr Tyr Gln Glu His Val Glu Val Ile Thr Asn
100 105 110
Ser Leu Thr Glu Ala Leu Pro Lys Val Glu Glu Ala Gln Ile Lys Gln
115 120 125
Ala Gln Leu Gln Glu Ala Leu Lys Gln Leu Gln Ala Lys Lys Gln Met
130 135 140
Ala Met Glu Lys Leu Arg Ile Ala Gln Lys Gln Trp Gln Leu Glu Gln
145 150 155 160
Glu Lys His Leu Gln Asn Leu Ala Glu Ala Ser Ser Glu Val Arg Glu
165 170 175
Arg Gln Thr Gly Ala Gln Gln Glu Leu Gln Arg Leu Tyr Gln Glu Leu
180 185 190
Gly Thr Leu Lys Gln Gln Ala Gly Gln Glu Lys Asp Lys Leu Gln Arg
195 200 205
His Gln Thr Phe Leu Gln Leu Leu Tyr Thr Leu Gln Gly Lys Gln Leu
210 215 220
Phe Asn Glu Ala Glu Ala Glu Ile Pro Gln Glu Leu Asp Leu Pro Lys
225 230 235 240
Asp Lys Leu Gln Gln Val Thr Gln Pro Gln Glu Gln Asn Thr Gln Asp
245 250 255
Thr Met Gly Arg Glu Ala Asp Asn Pro Gln Pro Val Gly Asp Ala Gly
260 265 270
Leu Pro Trp Leu Pro Gly Arg Gln Gln His Lys Glu Glu Ser
275 280 285
<210> 152
<211> 239
<212> PRT
<213> 牛
<400> 152
Met Gly Ala Ala Glu Ser Glu Val Glu Thr Ala Ala Arg Glu Val Leu
1 5 10 15
Ala Lys Val Ala Asp Ile Leu Glu Pro Val Gly Phe Gln Glu Glu Ala
20 25 30
Glu Leu Pro Ala Gln Ile Leu Ala Glu Phe Val Met Asp Ser Arg Lys
35 40 45
Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Val Asp Phe Leu Gln
50 55 60
Asn Phe Leu Val Gln Glu Gly Thr Ala Gln Asp Gln Asn Pro Leu Ala
65 70 75 80
Ser Glu Asp Thr Ser Arg Gln Lys Ala Leu Glu Ala Lys Glu Gln Trp
85 90 95
Lys Glu Leu Lys Ala Thr Tyr Gln Glu His Val Glu Val Ile Thr Asn
100 105 110
Ser Leu Thr Glu Ala Leu Pro Lys Val Glu Glu Ala Gln Ile Lys Gln
115 120 125
Ala Gln Leu Gln Glu Ala Leu Lys Gln Leu Gln Ala Lys Lys Gln Met
130 135 140
Ala Met Glu Lys Leu Arg Ile Ala Gln Lys Gln Trp Gln Leu Glu Gln
145 150 155 160
Glu Lys His Leu Gln Asn Leu Ala Glu Ala Ser Ser Glu Gly Lys Gln
165 170 175
Leu Phe Asn Glu Ala Glu Ala Glu Ile Pro Gln Glu Leu Asp Leu Pro
180 185 190
Lys Asp Lys Leu Gln Gln Val Thr Gln Pro Gln Glu Gln Asn Thr Gln
195 200 205
Asp Thr Met Gly Arg Glu Ala Asp Asn Pro Gln Pro Val Gly Asp Ala
210 215 220
Gly Leu Pro Trp Leu Pro Gly Arg Gln Gln His Lys Glu Glu Ser
225 230 235
<210> 153
<211> 110
<212> PRT
<213> 食蟹猴
<400> 153
Met Glu Glu Ala Gln Arg Lys Arg Thr Gln Leu Gln Glu Ala Phe Glu
1 5 10 15
Gln Leu Gln Ala Lys Lys Gln Val Ala Met Glu Lys Arg Arg Ala Ala
20 25 30
Gln Asn Gln Trp Gln Leu Gln Gln Glu Lys His Leu Gln His Leu Ala
35 40 45
Lys Val Ser Ala Glu Gly Lys Leu Leu Phe Pro Glu Ala Glu Ala Glu
50 55 60
Ala Glu Asn Leu Pro Asp Asp Lys Pro Gln Gln Leu Thr Arg Pro Gln
65 70 75 80
Glu Gln Ser Thr Gly Asp Thr Met Gly Arg Asp Ala Gly Val Ser Phe
85 90 95
Lys Ala Val Ser Leu Gln Pro Ala Gly Asp Ala Asn Leu Pro
100 105 110
<210> 154
<211> 110
<212> PRT
<213> 食蟹猴
<400> 154
Met Glu Glu Ala Gln Arg Lys Arg Thr Gln Leu Gln Glu Ala Phe Glu
1 5 10 15
Gln Leu Gln Ala Lys Lys Gln Val Ala Met Glu Lys Arg Arg Ala Ala
20 25 30
Gln Asn Gln Trp Gln Leu Gln Gln Glu Lys His Leu Gln His Leu Ala
35 40 45
Lys Val Ser Ala Glu Gly Lys Leu Leu Phe Pro Glu Ala Glu Ala Glu
50 55 60
Ala Glu Asn Leu Pro Asp Asp Lys Pro Gln Gln Leu Thr Arg Pro Gln
65 70 75 80
Glu Gln Ser Thr Gly Asp Thr Met Gly Arg Asp Ala Gly Val Ser Phe
85 90 95
Lys Ala Val Ser Leu Gln Pro Ala Gly Asp Ala Asn Leu Pro
100 105 110
<210> 155
<211> 277
<212> PRT
<213> 食蟹猴
<400> 155
Met Glu Ala Ala Glu Thr Glu Ala Glu Ala Ala Ala Leu Glu Val Leu
1 5 10 15
Ala Glu Val Ala Gly Ile Leu Glu Pro Val Gly Leu Gln Glu Glu Ala
20 25 30
Glu Leu Pro Ala Lys Ile Leu Val Glu Phe Val Val Asp Ser Gln Lys
35 40 45
Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Val Asp Phe Leu Gln
50 55 60
Asn Ile Leu Ala Gln Glu Asp Thr Ala Lys Gly Leu Asp Pro Leu Ala
65 70 75 80
Ser Glu Asp Thr Ser Arg Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp
85 90 95
Lys Glu Leu Lys Ala Thr Tyr Arg Glu His Val Glu Ala Ile Lys Ile
100 105 110
Gly Leu Thr Lys Ala Leu Thr Gln Met Glu Glu Ala Gln Arg Lys Arg
115 120 125
Thr Gln Leu Gln Glu Ala Phe Glu Gln Leu Gln Ala Lys Lys Gln Val
130 135 140
Ala Met Glu Lys Arg Arg Ala Ala Gln Asn Gln Trp Gln Leu Gln Gln
145 150 155 160
Glu Lys His Leu Gln His Leu Ala Lys Val Ser Ala Glu Val Arg Glu
165 170 175
Arg Lys Thr Gly Thr Gln Gln Glu Leu Glu Gly Val Phe Gln Lys Leu
180 185 190
Gly Asn Leu Lys Gln Gln Ala Glu Gln Glu Gln Asp Lys Leu Gln Arg
195 200 205
Tyr Gln Thr Phe Leu Gln Leu Leu Tyr Thr Leu Gln Gly Lys Leu Leu
210 215 220
Phe Pro Glu Ala Glu Ala Glu Ala Glu Asn Leu Pro Asp Asp Lys Pro
225 230 235 240
Gln Gln Leu Thr Arg Pro Gln Glu Gln Ser Thr Gly Asp Thr Met Gly
245 250 255
Arg Asp Ala Gly Val Ser Phe Lys Ala Val Ser Leu Gln Pro Ala Gly
260 265 270
Asp Ala Asn Leu Pro
275
<210> 156
<211> 338
<212> PRT
<213> 马
<400> 156
Met Glu Val Ala Glu Thr Lys Ala Glu Ala Ala Ala Leu Glu Thr Leu
1 5 10 15
Ala Glu Val Ala Asp Ile Leu Glu Pro Arg Gly Leu Gln Glu Glu Ala
20 25 30
Glu Val Pro Ala Gln Ile Leu Ala Glu Phe Val Thr Asp Ser Arg Lys
35 40 45
Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Val Asp Phe Leu Gln
50 55 60
Asn Phe Leu Ala Gln Glu Asp Thr Ala Gln Gly Leu Asp Pro Leu Ala
65 70 75 80
Ser Glu Asp Thr Ser Arg Gln Lys Ala Ile Ala Ala Lys Glu Gln Trp
85 90 95
Lys Glu Leu Lys Ala Thr Tyr Gln Glu His Val Glu Ala Ile Thr Ser
100 105 110
Ala Leu Thr Gln Val Leu Pro Lys Val Glu Glu Ala Gln Arg Lys Arg
115 120 125
Ala Gln Leu Gln Glu Ala Leu Glu Gln Leu Gln Ala Lys Lys Gln Val
130 135 140
Ala Ala Glu Lys Leu Arg Val Ala Gln Lys Gln Trp Gln Leu Gln Gln
145 150 155 160
Glu Lys His Leu Gln His Leu Ala Glu Val Ser Ala Glu Val Arg Glu
165 170 175
Arg Gln Thr Gly Met Lys Gln Glu Leu Glu Arg Leu Tyr Gln Glu Leu
180 185 190
Gly Thr Leu Lys Gln Glu Ala Gly Gln Glu Arg Glu Lys Leu Gln Arg
195 200 205
His Gln Thr Phe Leu Gln Leu Leu Tyr Thr Leu Gln Gly Lys Leu Leu
210 215 220
Leu Pro Glu Ala Glu Ala Glu Leu Pro Gln Glu Arg Asp Leu Pro Glu
225 230 235 240
Pro Lys Ser Gln Gln Val Thr Gln Ser Trp Glu Leu Asn Thr Gly Asp
245 250 255
Thr Met Glu Arg Val Gly Asp Val Ser Ser Lys Glu Leu Asp Phe Glu
260 265 270
Asp Ser Leu Lys Ser Gly Thr Arg Val Gly Ser Arg Val Glu Gly Gly
275 280 285
Val Gly Leu Ala Ser Arg Val Trp Gly Cys Ser Trp Val Gln Trp Gly
290 295 300
Asp Pro Arg Ala Gly Tyr Thr Gln Arg Ser Val Gly Lys Ser Pro Ile
305 310 315 320
Glu Val Leu Lys Gln Ala Gly Arg Asn Met Phe Leu Gln Phe Thr Leu
325 330 335
Ile Phe
<210> 157
<211> 274
<212> PRT
<213> 鸭嘴兽
<400> 157
Met Ala Ile Leu Ala Ser Gln Asp Gly Arg Glu Glu Ala Glu Ala Glu
1 5 10 15
Val Pro Ala Lys Leu Leu Ala Glu Phe Val Met Asp Ser Arg Lys Lys
20 25 30
Asp Lys Leu Leu Cys Ser Gln Leu His Val Val Gln Phe Leu Gln Asp
35 40 45
Phe Leu Glu His Met Asp Ala Ala Pro Gly Phe His Ile Ser Glu Glu
50 55 60
Glu Ile Arg Lys Glu Ala Asn Glu Ala Lys Gln Lys Trp Lys Asp Leu
65 70 75 80
Lys Gly Asp Tyr Gln Glu Leu Val Glu Lys Ile Glu Glu Ala Met Pro
85 90 95
Arg Val Leu Gln Gln Val Glu Ala Leu Gln Lys Lys Arg Glu Leu Leu
100 105 110
Glu Glu Ala Leu Ser Glu Tyr Gln Met Gln Lys His Ser Thr Glu Glu
115 120 125
Lys Leu Arg Ala Val Gln Glu Gln Lys Gln Arg Asp Gln Asn Cys Arg
130 135 140
Ala Met Gly Val Met Asn Glu Phe Pro Leu Asp Trp Lys Gln Gln Glu
145 150 155 160
Trp Gln Leu Arg Tyr Leu Lys Pro Ser Cys Val Cys Thr Leu Ala Val
165 170 175
Gln Pro Gly Leu Leu Gly Ser Ser Ser Leu Glu Ala Val Arg Leu Ile
180 185 190
Ser Val Glu Gly Leu Pro Asn Pro Pro Asp Leu Leu Leu Tyr Lys Gly
195 200 205
Pro Gly Gly Val Arg Pro Cys Asp Pro Asn Ser Ala Asp Pro Lys Ser
210 215 220
Leu Asn Met Gly Pro Ser Leu Arg Gly Ala Tyr Gly Lys Glu Gln Gln
225 230 235 240
Glu Leu Val Ile Tyr Gly Ala Lys Pro Ser Val Val Phe Leu Gly Gln
245 250 255
Glu Asp Trp Gln Asn Gly Val Thr Ile Glu Ala Pro Arg Val Ser Ser
260 265 270
Ser Gly
<210> 158
<211> 194
<212> PRT
<213> 短尾负鼠
<400> 158
Met Ala Ala Asp Val Thr Ala Arg Ala Ala Ala Val Ala Glu Ala Leu
1 5 10 15
Ala Ser Ala Ala Ala Thr Leu Glu Ala Pro Ser Val Gln Glu Asp Val
20 25 30
Ser Ser Ala Leu Leu Ala Glu Phe Leu Lys Asp Ser Arg Lys Lys Glu
35 40 45
Lys Leu Leu Trp Gly Gln Leu Gln Val Val Asp Ala Leu Gln Ser Phe
50 55 60
Leu Glu His Met Asp Glu Ala Val Asn Pro Glu Glu Glu Ile Arg Ala
65 70 75 80
Glu Val Ser Ala Ala His Arg Leu Trp Lys Asp Leu Lys Ala Glu Tyr
85 90 95
Leu Lys Gln Thr Glu Ala Val Glu Ala Ala Leu Leu Gln Ala Leu Val
100 105 110
Gln Leu Glu Ala Gly Gln Arg Lys Gln Leu Leu Leu Arg Ser Thr Leu
115 120 125
Gln Gln Ile Gln Thr Lys Gly Arg Ala Leu Glu Glu Trp Arg Ser Arg
130 135 140
Ala Gln Thr Trp Arg Arg Gln Glu Gln Glu Lys Arg Arg Gln Glu Leu
145 150 155 160
Thr Ala Arg Ala Gln Ala Gln Arg Glu Arg Leu Glu Asn Gly Gly Gln
165 170 175
Gln Gln Glu Gln Val Leu Met Leu Gln Gly Gln Glu Thr Gln Ser Ala
180 185 190
Gln Arg
<210> 159
<211> 286
<212> PRT
<213> 家犬
<400> 159
Met Ala Glu Ala Glu Val Gly Ala Arg Ala Gln Ala Leu Glu Ala Leu
1 5 10 15
Ala Ala Leu Gly Asp Ile Leu Glu Pro Val Gly Arg Gln Glu Glu Val
20 25 30
Glu Leu Pro Ala Gln Ile Leu Ala Glu Phe Val Met Asp Ser Arg Lys
35 40 45
Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Val Asp Phe Leu Gln
50 55 60
Asn Phe Leu Ala Gln Glu Gly Ile Val Gln Gly Leu Asp Pro Leu Ala
65 70 75 80
Ser Glu Asp Thr Ser Arg Gln Lys Ala Leu Ala Val Lys Glu Gln Trp
85 90 95
Lys Glu Leu Lys Ala Thr Tyr Gln Glu His Val Glu Ala Ile Thr Gly
100 105 110
Ala Leu Thr Gln Ala Leu Ala Lys Thr Glu Glu Ala Gln Ser Lys Arg
115 120 125
Val Gln Leu Gln Glu Ala Leu Glu Gln Leu Gln Ala Lys Lys Gln Val
130 135 140
Ala Met Glu Arg Ala Arg Thr Ala Gln Lys Gln Trp Gln Leu Gln Gln
145 150 155 160
Glu Lys Arg Leu Gln His Leu Ala Glu Ala Ser Ala Glu Val Arg Gln
165 170 175
Arg Gln Arg Gly Ala Gln Gln Glu Leu Glu Arg Leu Arg Gln Glu Leu
180 185 190
Gly Ala Leu Gln Gln Gln Ala Gly Gln Lys Arg Asp Arg Leu Gln Arg
195 200 205
His Gln Thr Phe Leu Arg Leu Leu His Ile Leu Gln Gly Glu Pro Leu
210 215 220
Leu Pro Gly Ala Glu Thr Glu Arg Pro Gln Glu Leu Gly Ile Pro Glu
225 230 235 240
Ala Lys Pro Arg Glu Gln Asn Thr Gly Asp Ala Val Gly Lys Asp Arg
245 250 255
Ser Val Pro Ser Gln Ala Asp Gly Leu Gln Pro Ala Arg Gly Thr Ser
260 265 270
Ser Arg Trp Phe Pro Glu Gly Gln Gln His Gly Lys Gly Thr
275 280 285
<210> 160
<211> 294
<212> PRT
<213> 牛
<400> 160
Met Glu Ala Ala Glu Thr Lys Ala Glu Ala Ala Ala Arg Glu Ala Leu
1 5 10 15
Ala Lys Val Ala Asp Ile Leu Glu Pro Thr Gly Leu Gln Glu Glu Ala
20 25 30
Glu Leu Pro Ala Gln Ile Leu Ala Glu Phe Val Met Asp Ser Arg Lys
35 40 45
Lys Asp Lys Leu Leu Cys Ser Gln Leu Gln Val Val Asp Phe Leu Gln
50 55 60
Asn Phe Leu Ile Gln Glu Asp Thr Ala Gln Gly Leu Asp Pro Leu Ala
65 70 75 80
Ser Glu Asp Thr Ser Arg Lys Arg Ala Ile Glu Ala Lys Glu Gln Trp
85 90 95
Lys Glu Leu Lys Ala Thr Tyr Gln Glu His Val Glu Ala Ile Thr Ser
100 105 110
Ala Leu Thr Gln Ala Leu Pro Lys Met Glu Glu Ala Gln Lys Lys Gln
115 120 125
Ala Gln Leu Gln Glu Thr Leu Glu Gln Leu Gln Ala Lys Lys Gln Val
130 135 140
Ala Val Glu Lys Leu Arg Ile Ala Gln Lys Gln Trp Gln Leu Gln Gln
145 150 155 160
Glu Lys His Leu Gln His Leu Thr Lys Val Ser Ala Glu Val Lys Glu
165 170 175
Arg Gln Met Gly Thr Gln Gln Glu Phe Glu Arg Leu Tyr Gln Glu Leu
180 185 190
Gly Ala Leu Lys Gln Gln Ala Arg Gln Glu Gln Asp Lys Leu Gln Arg
195 200 205
His Gln Thr Phe Leu Gln Leu Leu Tyr Thr Leu Gln Gly Lys Leu Leu
210 215 220
Phe Ser Glu Ala Glu Ala Glu Ala Gln Ile Pro Gln Glu Leu Asn Leu
225 230 235 240
Pro Lys Asp Lys Pro Leu Gln Leu Thr Gln Pro Gln Glu Gln Asn Pro
245 250 255
Gln Asp Ile Met Gly Arg Asp Gly Ser Val Ser Ser Lys Val Asp Ser
260 265 270
Pro Gln Pro Ile Gly Asp Ala Ser Leu Pro Trp Leu Pro Gly Ala Gln
275 280 285
Gln His Gly Glu Gly Ser
290
<210> 161
<211> 261
<212> PRT
<213> 人类
<400> 161
Met Ser Tyr Thr Pro Gly Val Gly Gly Asp Pro Ala Gln Leu Ala Gln
1 5 10 15
Arg Ile Ser Ser Asn Ile Gln Lys Ile Thr Gln Cys Ser Val Glu Ile
20 25 30
Gln Arg Thr Leu Asn Gln Leu Gly Thr Pro Gln Asp Ser Pro Glu Leu
35 40 45
Arg Gln Gln Leu Gln Gln Lys Gln Gln Tyr Thr Asn Gln Leu Ala Lys
50 55 60
Glu Thr Asp Lys Tyr Ile Lys Glu Phe Gly Ser Leu Pro Thr Thr Pro
65 70 75 80
Ser Glu Gln Arg Gln Arg Lys Ile Gln Lys Asp Arg Leu Val Ala Glu
85 90 95
Phe Thr Thr Ser Leu Thr Asn Phe Gln Lys Val Gln Arg Gln Ala Ala
100 105 110
Glu Arg Glu Lys Glu Phe Val Ala Arg Val Arg Ala Ser Ser Arg Val
115 120 125
Ser Gly Ser Phe Pro Glu Asp Ser Ser Lys Glu Arg Asn Leu Val Ser
130 135 140
Trp Glu Ser Gln Thr Gln Pro Gln Val Gln Val Gln Asp Glu Glu Ile
145 150 155 160
Thr Glu Asp Asp Leu Arg Leu Ile His Glu Arg Glu Ser Ser Ile Arg
165 170 175
Gln Leu Glu Ala Asp Ile Met Asp Ile Asn Glu Ile Phe Lys Asp Leu
180 185 190
Gly Met Met Ile His Glu Gln Gly Asp Val Ile Asp Ser Ile Glu Ala
195 200 205
Asn Val Glu Asn Ala Glu Val His Val Gln Gln Ala Asn Gln Gln Leu
210 215 220
Ser Arg Ala Ala Asp Tyr Gln Arg Lys Ser Arg Lys Thr Leu Cys Ile
225 230 235 240
Ile Ile Leu Ile Leu Val Ile Gly Val Ala Ile Ile Ser Leu Ile Ile
245 250 255
Trp Gly Leu Asn His
260
<210> 162
<211> 160
<212> PRT
<213> 人类
<400> 162
Met Asp Lys Leu Lys Lys Val Leu Ser Gly Gln Asp Thr Glu Asp Arg
1 5 10 15
Ser Gly Leu Ser Glu Val Val Glu Ala Ser Ser Leu Ser Trp Ser Thr
20 25 30
Arg Ile Lys Gly Phe Ile Ala Cys Phe Ala Ile Gly Ile Leu Cys Ser
35 40 45
Leu Leu Gly Thr Val Leu Leu Trp Val Pro Arg Lys Gly Leu His Leu
50 55 60
Phe Ala Val Phe Tyr Thr Phe Gly Asn Ile Ala Ser Ile Gly Ser Thr
65 70 75 80
Ile Phe Leu Met Gly Pro Val Lys Gln Leu Lys Arg Met Phe Glu Pro
85 90 95
Thr Arg Leu Ile Ala Thr Ile Met Val Leu Leu Cys Phe Ala Leu Thr
100 105 110
Leu Cys Ser Ala Phe Trp Trp His Asn Lys Gly Leu Ala Leu Ile Phe
115 120 125
Cys Ile Leu Gln Ser Leu Ala Leu Thr Trp Tyr Ser Leu Ser Phe Ile
130 135 140
Pro Phe Ala Arg Asp Ala Val Lys Lys Cys Phe Ala Val Cys Leu Ala
145 150 155 160
<210> 163
<211> 288
<212> PRT
<213> 普通狨
<400> 163
Met Lys Asp Arg Thr Gln Glu Leu Arg Thr Ala Lys Asp Ser Asp Asp
1 5 10 15
Asp Asp Asp Val Ala Val Thr Val Asp Arg Asp Arg Phe Met Asp Glu
20 25 30
Phe Phe Glu Gln Val Glu Glu Ile Arg Gly Phe Ile Asp Lys Ile Ala
35 40 45
Glu Asn Val Glu Glu Val Lys Arg Lys His Ser Ala Ile Leu Ala Ser
50 55 60
Pro Asn Pro Asp Glu Lys Thr Lys Glu Glu Leu Glu Glu Leu Met Ser
65 70 75 80
Asp Ile Lys Lys Thr Ala Asn Lys Val Arg Ser Lys Leu Lys Ser Ile
85 90 95
Glu Gln Ser Ile Glu Gln Glu Glu Gly Leu Asn Arg Ser Ser Ala Asp
100 105 110
Leu Arg Ile Arg Lys Thr Gln His Ser Thr Leu Ser Arg Lys Phe Val
115 120 125
Glu Val Met Ser Glu Tyr Asn Ala Thr Gln Ser Asp Tyr Arg Glu Arg
130 135 140
Cys Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Arg Thr Thr
145 150 155 160
Thr Ser Glu Glu Leu Glu Asp Met Leu Glu Ser Gly Asn Pro Ala Ile
165 170 175
Phe Ala Ser Gly Ile Ile Met Asp Ser Ser Ile Ser Lys Gln Ala Leu
180 185 190
Ser Glu Ile Glu Thr Arg His Ser Glu Ile Ile Lys Leu Glu Asn Ser
195 200 205
Ile Arg Glu Leu His Asp Met Phe Met Asp Met Ala Met Leu Val Glu
210 215 220
Ser Gln Gly Glu Met Ile Asp Arg Ile Glu Tyr Asn Val Glu His Ala
225 230 235 240
Val Asp Tyr Val Glu Arg Ala Val Ser Asp Thr Lys Lys Ala Val Lys
245 250 255
Tyr Gln Ser Lys Ala Arg Arg Lys Lys Ile Met Ile Ile Ile Cys Cys
260 265 270
Val Ile Leu Gly Ile Val Ile Ala Ser Thr Val Gly Gly Ile Phe Ala
275 280 285
<210> 164
<211> 210
<212> PRT
<213> 大猩猩
<400> 164
Met Ser Ala Lys Ser Ala Ile Ser Lys Glu Ile Phe Ala Pro Leu Asp
1 5 10 15
Glu Arg Met Leu Gly Ala Val Gln Val Lys Arg Arg Thr Lys Lys Lys
20 25 30
Ile Pro Phe Leu Ala Thr Gly Gly Gln Gly Glu Tyr Leu Thr Tyr Ile
35 40 45
Cys Leu Ser Val Thr Asn Lys Lys Pro Thr Gln Ala Ser Ile Thr Lys
50 55 60
Val Lys Gln Phe Glu Gly Ser Thr Ser Phe Val Arg Arg Ser Gln Trp
65 70 75 80
Met Leu Glu Gln Leu Arg Gln Val Asn Gly Ile Asp Pro Asn Gly Asp
85 90 95
Ser Ala Glu Phe Asp Leu Leu Phe Glu Asn Ala Phe Asp Gln Trp Val
100 105 110
Ala Ser Thr Ala Ser Glu Lys Cys Thr Phe Phe Gln Ile Leu His His
115 120 125
Thr Cys Gln Arg Tyr Leu Thr Asp Arg Lys Pro Glu Phe Ile Asn Cys
130 135 140
Gln Ser Lys Ile Met Gly Gly Asn Ser Ile Leu His Ser Ala Ala Asp
145 150 155 160
Ser Val Thr Ser Ala Val Gln Lys Ala Ser Gln Ala Leu Asn Glu Arg
165 170 175
Gly Glu Arg Leu Gly Arg Ala Glu Glu Lys Thr Glu Asp Leu Lys Asn
180 185 190
Ser Ala Gln Gln Phe Ala Glu Thr Ala His Lys Leu Ala Met Lys His
195 200 205
Lys Cys
210
<210> 165
<211> 136
<212> PRT
<213> 大猩猩
<400> 165
Met Ala Gly Ala Gly Ser Ala Ala Val Ser Gly Ala Gly Thr Pro Val
1 5 10 15
Ala Gly Pro Thr Gly Arg Asp Leu Phe Ala Glu Gly Leu Leu Glu Phe
20 25 30
Leu Arg Pro Ala Val Gln Gln Leu Asp Ser His Val His Ala Val Arg
35 40 45
Glu Ser Gln Val Glu Leu Arg Glu Gln Ile Asp Asn Leu Ala Thr Glu
50 55 60
Leu Cys Arg Ile Asn Glu Asp Gln Lys Val Ala Leu Asp Leu Asp Pro
65 70 75 80
Tyr Val Lys Lys Leu Leu Asn Ala Arg Arg Arg Val Val Leu Val Asn
85 90 95
Asn Ile Leu Gln Asn Ala Gln Glu Arg Leu Arg Arg Leu Asn His Ser
100 105 110
Val Ala Lys Glu Thr Ala Arg Arg Arg Ala Met Leu Asp Ser Gly Ile
115 120 125
Tyr Pro Pro Gly Ser Pro Gly Lys
130 135
<210> 166
<211> 307
<212> PRT
<213> 人类
<400> 166
Met Ala Ala Leu Ala Pro Leu Pro Pro Leu Pro Ala Gln Phe Lys Ser
1 5 10 15
Ile Gln His His Leu Arg Thr Ala Gln Glu His Asp Lys Arg Asp Pro
20 25 30
Val Val Ala Tyr Tyr Cys Arg Leu Tyr Ala Met Gln Thr Gly Met Lys
35 40 45
Ile Asp Ser Lys Thr Pro Glu Cys Arg Lys Phe Leu Ser Lys Leu Met
50 55 60
Asp Gln Leu Glu Ala Leu Lys Lys Gln Leu Gly Asp Asn Glu Ala Ile
65 70 75 80
Thr Gln Glu Ile Val Gly Cys Ala His Leu Glu Asn Tyr Ala Leu Lys
85 90 95
Met Phe Leu Tyr Ala Asp Asn Glu Asp Arg Ala Gly Arg Phe His Lys
100 105 110
Asn Met Ile Lys Ser Phe Tyr Thr Ala Ser Leu Leu Ile Asp Val Ile
115 120 125
Thr Val Phe Gly Glu Leu Thr Asp Glu Asn Val Lys His Arg Lys Tyr
130 135 140
Ala Arg Trp Lys Ala Thr Tyr Ile His Asn Cys Leu Lys Asn Gly Glu
145 150 155 160
Thr Pro Gln Ala Gly Pro Val Gly Ile Glu Glu Asp Asn Asp Ile Glu
165 170 175
Glu Asn Glu Asp Ala Gly Ala Ala Ser Leu Pro Thr Gln Pro Thr Gln
180 185 190
Pro Ser Ser Ser Ser Thr Tyr Asp Pro Ser Asn Met Pro Ser Gly Asn
195 200 205
Tyr Thr Gly Ile Gln Ile Pro Pro Gly Ala His Ala Pro Ala Asn Thr
210 215 220
Pro Ala Glu Val Pro His Ser Thr Gly Val Ala Ser Asn Thr Ile Gln
225 230 235 240
Pro Thr Pro Gln Thr Ile Pro Ala Ile Asp Pro Ala Leu Phe Asn Thr
245 250 255
Ile Ser Gln Gly Asp Val Arg Leu Thr Pro Glu Asp Phe Ala Arg Ala
260 265 270
Gln Lys Tyr Cys Lys Tyr Ala Gly Ser Ala Leu Gln Tyr Glu Asp Val
275 280 285
Ser Thr Ala Val Gln Asn Leu Gln Lys Ala Leu Lys Leu Leu Thr Thr
290 295 300
Gly Arg Glu
305
<210> 167
<211> 100
<212> PRT
<213> 人类
<400> 167
Met Glu Glu Ala Ser Glu Gly Gly Gly Asn Asp Arg Val Arg Asn Leu
1 5 10 15
Gln Ser Glu Val Glu Gly Val Lys Asn Ile Met Thr Gln Asn Val Glu
20 25 30
Arg Ile Leu Ala Arg Gly Glu Asn Leu Glu His Leu Arg Asn Lys Thr
35 40 45
Glu Asp Leu Glu Ala Thr Ser Glu His Phe Lys Thr Thr Ser Gln Lys
50 55 60
Val Ala Arg Lys Phe Trp Trp Lys Asn Val Lys Met Ile Val Leu Ile
65 70 75 80
Cys Val Ile Val Phe Ile Ile Ile Leu Phe Ile Val Leu Phe Ala Thr
85 90 95
Gly Ala Phe Ser
100
<210> 168
<211> 141
<212> PRT
<213> 人类
<400> 168
Met Pro Pro Lys Phe Lys Arg His Leu Asn Asp Asp Asp Val Thr Gly
1 5 10 15
Ser Val Lys Ser Glu Arg Arg Asn Leu Leu Glu Asp Asp Ser Asp Glu
20 25 30
Glu Glu Asp Phe Phe Leu Arg Gly Pro Ser Gly Pro Arg Phe Gly Pro
35 40 45
Arg Asn Asp Lys Ile Lys His Val Gln Asn Gln Val Asp Glu Val Ile
50 55 60
Asp Val Met Gln Glu Asn Ile Thr Lys Val Ile Glu Arg Gly Glu Arg
65 70 75 80
Leu Asp Glu Leu Gln Asp Lys Ser Glu Ser Leu Ser Asp Asn Ala Thr
85 90 95
Ala Phe Ser Asn Arg Ser Lys Gln Leu Arg Arg Gln Met Trp Trp Arg
100 105 110
Gly Cys Lys Ile Lys Ala Ile Met Ala Leu Val Ala Ala Ile Leu Leu
115 120 125
Leu Val Ile Ile Ile Leu Ile Val Met Lys Tyr Arg Thr
130 135 140
<210> 169
<211> 258
<212> PRT
<213> 人类
<400> 169
Met Ser Ala Tyr Pro Lys Ser Tyr Asn Pro Phe Asp Asp Asp Gly Glu
1 5 10 15
Asp Glu Gly Ala Arg Pro Ala Pro Trp Arg Asp Ala Arg Asp Leu Pro
20 25 30
Asp Gly Pro Asp Ala Pro Ala Asp Arg Gln Gln Tyr Leu Arg Gln Glu
35 40 45
Val Leu Arg Arg Ala Glu Ala Thr Ala Ala Ser Thr Ser Arg Ser Leu
50 55 60
Ala Leu Met Tyr Glu Ser Glu Lys Val Gly Val Ala Ser Ser Glu Glu
65 70 75 80
Leu Ala Arg Gln Arg Gly Val Leu Glu Arg Thr Glu Lys Met Val Asp
85 90 95
Lys Met Asp Gln Asp Leu Lys Ile Ser Gln Lys His Ile Asn Ser Ile
100 105 110
Lys Ser Val Phe Gly Gly Leu Val Asn Tyr Phe Lys Ser Lys Pro Val
115 120 125
Glu Thr Pro Pro Glu Gln Asn Gly Thr Leu Thr Ser Gln Pro Asn Asn
130 135 140
Arg Leu Lys Glu Ala Ile Ser Thr Ser Lys Glu Gln Glu Ala Lys Tyr
145 150 155 160
Gln Ala Ser His Pro Asn Leu Arg Lys Leu Asp Asp Thr Asp Pro Val
165 170 175
Pro Arg Gly Ala Gly Ser Ala Met Ser Thr Asp Ala Tyr Pro Lys Asn
180 185 190
Pro His Leu Arg Ala Tyr His Gln Lys Ile Asp Ser Asn Leu Asp Glu
195 200 205
Leu Ser Met Gly Leu Gly Arg Leu Lys Asp Ile Ala Leu Gly Met Gln
210 215 220
Thr Glu Ile Glu Glu Gln Asp Asp Ile Leu Asp Arg Leu Thr Thr Lys
225 230 235 240
Val Asp Lys Leu Asp Val Asn Ile Lys Ser Thr Glu Arg Lys Val Arg
245 250 255
Gln Leu
<210> 170
<211> 116
<212> PRT
<213> 家犬
<400> 170
Met Ser Ala Thr Ala Ala Thr Ala Pro Pro Ala Ala Pro Ala Gly Glu
1 5 10 15
Gly Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu
20 25 30
Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val
35 40 45
Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp
50 55 60
Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser
65 70 75 80
Ala Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met
85 90 95
Ile Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val
100 105 110
Tyr Phe Ser Ser
115
<210> 171
<211> 116
<212> PRT
<213> 人类
<400> 171
Met Ala Gly Ile Glu Leu Glu Arg Cys Gln Gln Gln Ala Asn Glu Val
1 5 10 15
Thr Glu Ile Met Arg Asn Asn Phe Gly Lys Val Leu Glu Arg Gly Val
20 25 30
Lys Leu Ala Glu Leu Gln Gln Arg Ser Asp Gln Leu Leu Asp Met Ser
35 40 45
Ser Thr Phe Asn Lys Thr Thr Gln Asn Leu Ala Gln Lys Lys Cys Trp
50 55 60
Glu Asn Ile Arg Tyr Arg Ile Cys Val Gly Leu Val Val Val Gly Val
65 70 75 80
Leu Leu Ile Ile Leu Ile Val Leu Leu Val Val Phe Leu Pro Gln Ser
85 90 95
Ser Asp Ser Ser Ser Ala Pro Arg Thr Gln Asp Ala Gly Ile Ala Ser
100 105 110
Gly Pro Gly Asn
115
<210> 172
<211> 206
<212> PRT
<213> 人类
<400> 172
Met Ala Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg
1 5 10 15
Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met
20 25 30
Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val
35 40 45
Met Leu Asp Glu Gln Gly Glu Gln Leu Asp Arg Val Glu Glu Gly Met
50 55 60
Asn His Ile Asn Gln Asp Met Lys Glu Ala Glu Lys Asn Leu Lys Asp
65 70 75 80
Leu Gly Lys Cys Cys Gly Leu Phe Ile Cys Pro Cys Asn Lys Leu Lys
85 90 95
Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val
100 105 110
Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala
115 120 125
Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn
130 135 140
Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu
145 150 155 160
Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg
165 170 175
Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile
180 185 190
Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly
195 200 205
<210> 173
<211> 206
<212> PRT
<213> 小家鼠
<400> 173
Met Ala Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg
1 5 10 15
Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met
20 25 30
Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val
35 40 45
Met Leu Asp Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met
50 55 60
Asp Gln Ile Asn Lys Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp
65 70 75 80
Leu Gly Lys Phe Cys Gly Leu Cys Val Cys Pro Cys Asn Lys Leu Lys
85 90 95
Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val
100 105 110
Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala
115 120 125
Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn
130 135 140
Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu
145 150 155 160
Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg
165 170 175
Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile
180 185 190
Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly
195 200 205
<210> 174
<211> 220
<212> PRT
<213> 人类
<400> 174
Met Ala Ile Leu Phe Ala Val Val Ala Arg Gly Thr Thr Ile Leu Ala
1 5 10 15
Lys His Ala Trp Cys Gly Gly Asn Phe Leu Glu Val Thr Glu Gln Ile
20 25 30
Leu Ala Lys Ile Pro Ser Glu Asn Asn Lys Leu Thr Tyr Ser His Gly
35 40 45
Asn Tyr Leu Phe His Tyr Ile Cys Gln Asp Arg Ile Val Tyr Leu Cys
50 55 60
Ile Thr Asp Asp Asp Phe Glu Arg Ser Arg Ala Phe Asn Phe Leu Asn
65 70 75 80
Glu Ile Lys Lys Arg Phe Gln Thr Thr Tyr Gly Ser Arg Ala Gln Thr
85 90 95
Ala Leu Pro Tyr Ala Met Asn Ser Glu Phe Ser Ser Val Leu Ala Ala
100 105 110
Gln Leu Lys His His Ser Glu Asn Lys Gly Leu Asp Lys Val Met Glu
115 120 125
Thr Gln Ala Gln Val Asp Glu Leu Lys Gly Ile Met Val Arg Asn Ile
130 135 140
Asp Leu Val Ala Gln Arg Gly Glu Arg Leu Glu Leu Leu Ile Asp Lys
145 150 155 160
Thr Glu Asn Leu Val Asp Ser Ser Val Thr Phe Lys Thr Thr Ser Arg
165 170 175
Asn Leu Ala Arg Ala Met Cys Met Lys Asn Leu Lys Leu Thr Ile Ile
180 185 190
Ile Ile Ile Val Ser Ile Val Phe Ile Tyr Ile Ile Val Ser Pro Leu
195 200 205
Cys Gly Gly Phe Thr Trp Pro Ser Cys Val Lys Lys
210 215 220
<210> 175
<211> 288
<212> PRT
<213> 褐家鼠
<400> 175
Met Lys Asp Arg Thr Gln Glu Leu Arg Ser Ala Lys Asp Ser Asp Asp
1 5 10 15
Glu Glu Glu Val Val His Val Asp Arg Asp His Phe Met Asp Glu Phe
20 25 30
Phe Glu Gln Val Glu Glu Ile Arg Gly Cys Ile Glu Lys Leu Ser Glu
35 40 45
Asp Val Glu Gln Val Lys Lys Gln His Ser Ala Ile Leu Ala Ala Pro
50 55 60
Asn Pro Asp Glu Lys Thr Lys Gln Glu Leu Glu Asp Leu Thr Ala Asp
65 70 75 80
Ile Lys Lys Thr Ala Asn Lys Val Arg Ser Lys Leu Lys Ala Ile Glu
85 90 95
Gln Ser Ile Glu Gln Glu Glu Gly Leu Asn Arg Ser Ser Ala Asp Leu
100 105 110
Arg Ile Arg Lys Thr Gln His Ser Thr Leu Ser Arg Lys Phe Val Glu
115 120 125
Val Met Thr Glu Tyr Asn Ala Thr Gln Ser Lys Tyr Arg Asp Arg Cys
130 135 140
Lys Asp Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Arg Thr Thr Thr
145 150 155 160
Asn Glu Glu Leu Glu Asp Met Leu Glu Ser Gly Lys Leu Ala Ile Phe
165 170 175
Thr Asp Asp Ile Lys Met Asp Ser Gln Met Thr Lys Gln Ala Leu Asn
180 185 190
Glu Ile Glu Thr Arg His Asn Glu Ile Ile Lys Leu Glu Thr Ser Ile
195 200 205
Arg Glu Leu His Asp Met Phe Val Asp Met Ala Met Leu Val Glu Ser
210 215 220
Gln Gly Glu Met Ile Asp Arg Ile Glu Tyr Asn Val Glu His Ser Val
225 230 235 240
Asp Tyr Val Glu Arg Ala Val Ser Asp Thr Lys Lys Ala Val Lys Tyr
245 250 255
Gln Ser Lys Ala Arg Arg Lys Lys Ile Met Ile Ile Ile Cys Cys Val
260 265 270
Val Leu Gly Val Val Leu Ala Ser Ser Ile Gly Gly Thr Leu Gly Leu
275 280 285
<210> 176
<211> 302
<212> PRT
<213> 人类
<400> 176
Met Ser Glu Asp Glu Glu Lys Val Lys Leu Arg Arg Leu Glu Pro Ala
1 5 10 15
Ile Gln Lys Phe Ile Lys Ile Val Ile Pro Thr Asp Leu Glu Arg Leu
20 25 30
Arg Lys His Gln Ile Asn Ile Glu Lys Tyr Gln Arg Cys Arg Ile Trp
35 40 45
Asp Lys Leu His Glu Glu His Ile Asn Ala Gly Arg Thr Val Gln Gln
50 55 60
Leu Arg Ser Asn Ile Arg Glu Ile Glu Lys Leu Cys Leu Lys Val Arg
65 70 75 80
Lys Asp Asp Leu Val Leu Leu Lys Arg Met Ile Asp Pro Val Lys Glu
85 90 95
Glu Ala Ser Ala Ala Thr Ala Glu Phe Leu Gln Leu His Leu Glu Ser
100 105 110
Val Glu Glu Leu Lys Lys Gln Phe Asn Asp Glu Glu Thr Leu Leu Gln
115 120 125
Pro Pro Leu Thr Arg Ser Met Thr Val Gly Gly Ala Phe His Thr Thr
130 135 140
Glu Ala Glu Ala Ser Ser Gln Ser Leu Thr Gln Ile Tyr Ala Leu Pro
145 150 155 160
Glu Ile Pro Gln Asp Gln Asn Ala Ala Glu Ser Trp Glu Thr Leu Glu
165 170 175
Ala Asp Leu Ile Glu Leu Ser Gln Leu Val Thr Asp Phe Ser Leu Leu
180 185 190
Val Asn Ser Gln Gln Glu Lys Ile Asp Ser Ile Ala Asp His Val Asn
195 200 205
Ser Ala Ala Val Asn Val Glu Glu Gly Thr Lys Asn Leu Gly Lys Ala
210 215 220
Ala Lys Tyr Lys Leu Ala Ala Leu Pro Val Ala Gly Ala Leu Ile Gly
225 230 235 240
Gly Met Val Gly Gly Pro Ile Gly Leu Leu Ala Gly Phe Lys Val Ala
245 250 255
Gly Ile Ala Ala Ala Leu Gly Gly Gly Val Leu Gly Phe Thr Gly Gly
260 265 270
Lys Leu Ile Gln Arg Lys Lys Gln Lys Met Met Glu Lys Leu Thr Ser
275 280 285
Ser Cys Pro Asp Leu Pro Ser Gln Thr Asp Lys Lys Cys Ser
290 295 300
<210> 177
<211> 259
<212> PRT
<213> 人类
<400> 177
Met Ala Ala Ser Arg Leu Glu Leu Asn Leu Val Arg Leu Leu Ser Arg
1 5 10 15
Cys Glu Ala Met Ala Ala Glu Lys Arg Asp Pro Asp Glu Trp Arg Leu
20 25 30
Glu Lys Tyr Val Gly Ala Leu Glu Asp Met Leu Gln Ala Leu Lys Val
35 40 45
His Ala Ser Lys Pro Ala Ser Glu Val Ile Asn Glu Tyr Ser Trp Lys
50 55 60
Val Asp Phe Leu Lys Gly Met Leu Gln Ala Glu Lys Leu Thr Ser Ser
65 70 75 80
Ser Glu Lys Ala Leu Ala Asn Gln Phe Leu Ala Pro Gly Arg Val Pro
85 90 95
Thr Thr Ala Arg Glu Arg Val Pro Ala Thr Lys Thr Val His Leu Gln
100 105 110
Ser Arg Ala Arg Tyr Thr Ser Glu Met Arg Ser Glu Leu Leu Gly Thr
115 120 125
Asp Ser Ala Glu Pro Glu Met Asp Val Arg Lys Arg Thr Gly Val Ala
130 135 140
Gly Ser Gln Pro Val Ser Glu Lys Gln Ser Ala Ala Glu Leu Asp Leu
145 150 155 160
Val Leu Gln Arg His Gln Asn Leu Gln Glu Lys Leu Ala Glu Glu Met
165 170 175
Leu Gly Leu Ala Arg Ser Leu Lys Thr Asn Thr Leu Ala Ala Gln Ser
180 185 190
Val Ile Lys Lys Asp Asn Gln Thr Leu Ser His Ser Leu Lys Met Ala
195 200 205
Asp Gln Asn Leu Glu Lys Leu Lys Thr Glu Ser Glu Arg Leu Glu Gln
210 215 220
His Thr Gln Lys Ser Val Asn Trp Leu Leu Trp Ala Met Leu Ile Ile
225 230 235 240
Val Cys Phe Ile Phe Ile Ser Met Ile Leu Phe Ile Arg Ile Met Pro
245 250 255
Lys Leu Lys
<210> 178
<211> 276
<212> PRT
<213> 人类
<400> 178
Met Ser Tyr Gly Pro Leu Asp Met Tyr Arg Asn Pro Gly Pro Ser Gly
1 5 10 15
Pro Gln Leu Arg Asp Phe Ser Ser Ile Ile Gln Thr Cys Ser Gly Asn
20 25 30
Ile Gln Arg Ile Ser Gln Ala Thr Ala Gln Ile Lys Asn Leu Met Ser
35 40 45
Gln Leu Gly Thr Lys Gln Asp Ser Ser Lys Leu Gln Glu Asn Leu Gln
50 55 60
Gln Leu Gln His Ser Thr Asn Gln Leu Ala Lys Glu Thr Asn Glu Leu
65 70 75 80
Leu Lys Glu Leu Gly Ser Leu Pro Leu Pro Leu Ser Thr Ser Glu Gln
85 90 95
Arg Gln Gln Arg Leu Gln Lys Glu Arg Leu Met Asn Asp Phe Ser Ala
100 105 110
Ala Leu Asn Asn Phe Gln Ala Val Gln Arg Arg Val Ser Glu Lys Glu
115 120 125
Lys Glu Ser Ile Ala Arg Ala Arg Ala Gly Ser Arg Leu Ser Ala Glu
130 135 140
Glu Arg Gln Arg Glu Glu Gln Leu Val Ser Phe Asp Ser His Glu Glu
145 150 155 160
Trp Asn Gln Met Gln Ser Gln Glu Asp Glu Val Ala Ile Thr Glu Gln
165 170 175
Asp Leu Glu Leu Ile Lys Glu Arg Glu Thr Ala Ile Arg Gln Leu Glu
180 185 190
Ala Asp Ile Leu Asp Val Asn Gln Ile Phe Lys Asp Leu Ala Met Met
195 200 205
Ile His Asp Gln Gly Asp Leu Ile Asp Ser Ile Glu Ala Asn Val Glu
210 215 220
Ser Ser Glu Val His Val Glu Arg Ala Thr Glu Gln Leu Gln Arg Ala
225 230 235 240
Ala Tyr Tyr Gln Lys Lys Ser Arg Lys Lys Met Cys Ile Leu Val Leu
245 250 255
Val Leu Ser Val Ile Ile Leu Ile Leu Gly Leu Ile Ile Trp Leu Val
260 265 270
Tyr Lys Thr Lys
275
<210> 179
<211> 592
<212> PRT
<213> 人类
<400> 179
Met Ala Pro Pro Val Ala Glu Arg Gly Leu Lys Ser Val Val Trp Gln
1 5 10 15
Lys Ile Lys Ala Thr Val Phe Asp Asp Cys Lys Lys Glu Gly Glu Trp
20 25 30
Lys Ile Met Leu Leu Asp Glu Phe Thr Thr Lys Leu Leu Ala Ser Cys
35 40 45
Cys Lys Met Thr Asp Leu Leu Glu Glu Gly Ile Thr Val Val Glu Asn
50 55 60
Ile Tyr Lys Asn Arg Glu Pro Val Arg Gln Met Lys Ala Leu Tyr Phe
65 70 75 80
Ile Thr Pro Thr Ser Lys Ser Val Asp Cys Phe Leu His Asp Phe Ala
85 90 95
Ser Lys Ser Glu Asn Lys Tyr Lys Ala Ala Tyr Ile Tyr Phe Thr Asp
100 105 110
Phe Cys Pro Asp Asn Leu Phe Asn Lys Ile Lys Ala Ser Cys Ser Lys
115 120 125
Ser Ile Arg Arg Cys Lys Glu Ile Asn Ile Ser Phe Ile Pro His Glu
130 135 140
Ser Gln Val Tyr Thr Leu Asp Val Pro Asp Ala Phe Tyr Tyr Cys Tyr
145 150 155 160
Ser Pro Asp Pro Gly Asn Ala Lys Gly Lys Asp Ala Ile Met Glu Thr
165 170 175
Met Ala Asp Gln Ile Val Thr Val Cys Ala Thr Leu Asp Glu Asn Pro
180 185 190
Gly Val Arg Tyr Lys Ser Lys Pro Leu Asp Asn Ala Ser Lys Leu Ala
195 200 205
Gln Leu Val Glu Lys Lys Leu Glu Asp Tyr Tyr Lys Ile Asp Glu Lys
210 215 220
Ser Leu Ile Lys Gly Lys Thr His Ser Gln Leu Leu Ile Ile Asp Arg
225 230 235 240
Gly Phe Asp Pro Val Ser Thr Val Leu His Glu Leu Thr Phe Gln Ala
245 250 255
Met Ala Tyr Asp Leu Leu Pro Ile Glu Asn Asp Thr Tyr Lys Tyr Lys
260 265 270
Thr Asp Gly Lys Glu Lys Glu Ala Ile Leu Glu Glu Glu Asp Asp Leu
275 280 285
Trp Val Arg Ile Arg His Arg His Ile Ala Val Val Leu Glu Glu Ile
290 295 300
Pro Lys Leu Met Lys Glu Ile Ser Ser Thr Lys Lys Ala Thr Glu Gly
305 310 315 320
Lys Thr Ser Leu Ser Ala Leu Thr Gln Leu Met Lys Lys Met Pro His
325 330 335
Phe Arg Lys Gln Ile Thr Lys Gln Val Val His Leu Asn Leu Ala Glu
340 345 350
Asp Cys Met Asn Lys Phe Lys Leu Asn Ile Glu Lys Leu Cys Lys Thr
355 360 365
Glu Gln Asp Leu Ala Leu Gly Thr Asp Ala Glu Gly Gln Lys Val Lys
370 375 380
Asp Ser Met Arg Val Leu Leu Pro Val Leu Leu Asn Lys Asn His Asp
385 390 395 400
Asn Cys Asp Lys Ile Arg Ala Ile Leu Leu Tyr Ile Phe Ser Ile Asn
405 410 415
Gly Thr Thr Glu Glu Asn Leu Asp Arg Leu Ile Gln Asn Val Lys Ile
420 425 430
Glu Asn Glu Ser Asp Met Ile Arg Asn Trp Ser Tyr Leu Gly Val Pro
435 440 445
Ile Val Pro Gln Ser Gln Gln Gly Lys Pro Leu Arg Lys Asp Arg Ser
450 455 460
Ala Glu Glu Thr Phe Gln Leu Ser Arg Trp Thr Pro Phe Ile Lys Asp
465 470 475 480
Ile Met Glu Asp Ala Ile Asp Asn Arg Leu Asp Ser Lys Glu Trp Pro
485 490 495
Tyr Cys Ser Gln Cys Pro Ala Val Trp Asn Gly Ser Gly Ala Val Ser
500 505 510
Ala Arg Gln Lys Pro Arg Ala Asn Tyr Leu Glu Asp Arg Lys Asn Gly
515 520 525
Ser Lys Leu Ile Val Phe Val Ile Gly Gly Ile Thr Tyr Ser Glu Val
530 535 540
Arg Cys Ala Tyr Glu Val Ser Gln Ala His Lys Ser Cys Glu Val Ile
545 550 555 560
Ile Gly Ser Thr His Val Leu Thr Pro Lys Lys Leu Leu Asp Asp Ile
565 570 575
Lys Met Leu Asn Lys Pro Lys Asp Lys Val Ser Leu Ile Lys Asp Glu
580 585 590
<210> 180
<211> 454
<212> PRT
<213> 人类
<400> 180
Met Ser Ala Gly Gly Pro Cys Pro Ala Ala Ala Gly Gly Gly Pro Gly
1 5 10 15
Gly Ala Ser Cys Ser Val Gly Ala Pro Gly Gly Val Ser Met Phe Arg
20 25 30
Trp Leu Glu Val Leu Glu Lys Glu Phe Asp Lys Ala Phe Val Asp Val
35 40 45
Asp Leu Leu Leu Gly Glu Ile Asp Pro Asp Gln Ala Asp Ile Thr Tyr
50 55 60
Glu Gly Arg Gln Lys Met Thr Ser Leu Ser Ser Cys Phe Ala Gln Leu
65 70 75 80
Cys His Lys Ala Gln Ser Val Ser Gln Ile Asn His Lys Leu Glu Ala
85 90 95
Gln Leu Val Asp Leu Lys Ser Glu Leu Thr Glu Thr Gln Ala Glu Lys
100 105 110
Val Val Leu Glu Lys Glu Val His Asp Gln Leu Leu Gln Leu His Ser
115 120 125
Ile Gln Leu Gln Leu His Ala Lys Thr Gly Gln Ser Ala Asp Ser Gly
130 135 140
Thr Ile Lys Ala Lys Leu Glu Arg Glu Leu Glu Ala Asn Lys Lys Glu
145 150 155 160
Lys Met Lys Glu Ala Gln Leu Glu Ala Glu Val Lys Leu Leu Arg Lys
165 170 175
Glu Asn Glu Ala Leu Arg Arg His Ile Ala Val Leu Gln Ala Glu Val
180 185 190
Tyr Gly Ala Arg Leu Ala Ala Lys Tyr Leu Asp Lys Glu Leu Ala Gly
195 200 205
Arg Val Gln Gln Ile Gln Leu Leu Gly Arg Asp Met Lys Gly Pro Ala
210 215 220
His Asp Lys Leu Trp Asn Gln Leu Glu Ala Glu Ile His Leu His Arg
225 230 235 240
His Lys Thr Val Ile Arg Ala Cys Arg Gly Arg Asn Asp Leu Lys Arg
245 250 255
Pro Met Gln Ala Pro Pro Gly His Asp Gln Asp Ser Leu Lys Lys Ser
260 265 270
Gln Gly Val Gly Pro Ile Arg Lys Val Leu Leu Leu Lys Glu Asp His
275 280 285
Glu Gly Leu Gly Ile Ser Ile Thr Gly Gly Lys Glu His Gly Val Pro
290 295 300
Ile Leu Ile Ser Glu Ile His Pro Gly Gln Pro Ala Asp Arg Cys Gly
305 310 315 320
Gly Leu His Val Gly Asp Ala Ile Leu Ala Val Asn Gly Val Asn Leu
325 330 335
Arg Asp Thr Lys His Lys Glu Ala Val Thr Ile Leu Ser Gln Gln Arg
340 345 350
Gly Glu Ile Glu Phe Glu Val Val Tyr Val Ala Pro Glu Val Asp Ser
355 360 365
Asp Asp Glu Asn Val Glu Tyr Glu Asp Glu Ser Gly His Arg Tyr Arg
370 375 380
Leu Tyr Leu Asp Glu Leu Glu Gly Gly Gly Asn Pro Gly Ala Ser Cys
385 390 395 400
Lys Asp Thr Ser Gly Glu Ile Lys Val Leu Gln Gly Phe Asn Lys Lys
405 410 415
Ala Val Thr Asp Thr His Glu Asn Gly Asp Leu Gly Thr Ala Ser Glu
420 425 430
Thr Pro Leu Asp Asp Gly Ala Ser Lys Leu Asp Asp Leu His Thr Leu
435 440 445
Tyr His Lys Lys Ser Tyr
450
<210> 181
<211> 195
<212> PRT
<213> 人类
<400> 181
Met Asp Pro Leu Phe Gln Gln Thr His Lys Gln Val His Glu Ile Gln
1 5 10 15
Ser Cys Met Gly Arg Leu Glu Thr Ala Asp Lys Gln Ser Val His Ile
20 25 30
Val Glu Asn Glu Ile Gln Ala Ser Ile Asp Gln Ile Phe Ser Arg Leu
35 40 45
Glu Arg Leu Glu Ile Leu Ser Ser Lys Glu Pro Pro Asn Lys Arg Gln
50 55 60
Asn Ala Arg Leu Arg Val Asp Gln Leu Lys Tyr Asp Val Gln His Leu
65 70 75 80
Gln Thr Ala Leu Arg Asn Phe Gln His Arg Arg His Ala Arg Glu Gln
85 90 95
Gln Glu Arg Gln Arg Glu Glu Leu Leu Ser Arg Thr Phe Thr Thr Asn
100 105 110
Asp Ser Asp Thr Thr Ile Pro Met Asp Glu Ser Leu Gln Phe Asn Ser
115 120 125
Ser Leu Gln Lys Val His Asn Gly Met Asp Asp Leu Ile Leu Asp Gly
130 135 140
His Asn Ile Leu Asp Gly Leu Arg Thr Gln Arg Leu Thr Leu Lys Val
145 150 155 160
Gly Ser Leu Leu Gly Asp Arg Glu Lys Ala Ser Cys Phe Ser Leu Ile
165 170 175
Gln Gln Phe Ser Asn Cys Val Tyr Ile Leu Ile Thr Cys Pro Gln Ile
180 185 190
Val Ile Phe
195
<210> 182
<211> 325
<212> PRT
<213> 人类
<400> 182
Met Ala Thr Arg Arg Leu Thr Asp Ala Phe Leu Leu Leu Arg Asn Asn
1 5 10 15
Ser Ile Gln Asn Arg Gln Leu Leu Ala Glu Gln Val Ser Ser His Ile
20 25 30
Thr Ser Ser Pro Leu His Ser Arg Ser Ile Ala Ala Glu Leu Asp Glu
35 40 45
Leu Ala Asp Asp Arg Met Ala Leu Val Ser Gly Ile Ser Leu Asp Pro
50 55 60
Glu Ala Ala Ile Gly Val Thr Lys Arg Pro Pro Pro Lys Trp Val Asp
65 70 75 80
Gly Val Asp Glu Ile Gln Tyr Asp Val Gly Arg Ile Lys Gln Lys Met
85 90 95
Lys Glu Leu Ala Ser Leu His Asp Lys His Leu Asn Arg Pro Thr Leu
100 105 110
Asp Asp Ser Ser Glu Glu Glu His Ala Ile Glu Ile Thr Thr Gln Glu
115 120 125
Ile Thr Gln Leu Phe His Arg Cys Gln Arg Ala Val Gln Ala Leu Pro
130 135 140
Ser Arg Ala Arg Ala Cys Ser Glu Gln Glu Gly Arg Leu Leu Gly Asn
145 150 155 160
Val Val Ala Ser Leu Ala Gln Ala Leu Gln Glu Leu Ser Thr Ser Phe
165 170 175
Arg His Ala Gln Ser Gly Tyr Leu Lys Arg Met Lys Asn Arg Glu Glu
180 185 190
Arg Ser Gln His Phe Phe Asp Thr Ser Val Pro Leu Met Asp Asp Gly
195 200 205
Asp Asp Asn Thr Leu Tyr His Arg Gly Phe Thr Glu Asp Gln Leu Val
210 215 220
Leu Val Glu Gln Asn Thr Leu Met Val Glu Glu Arg Glu Arg Glu Ile
225 230 235 240
Arg Gln Ile Val Gln Ser Ile Ser Asp Leu Asn Glu Ile Phe Arg Asp
245 250 255
Leu Gly Ala Met Ile Val Glu Gln Gly Thr Val Leu Asp Arg Ile Asp
260 265 270
Tyr Asn Val Glu Gln Ser Cys Ile Lys Thr Glu Asp Gly Leu Lys Gln
275 280 285
Leu His Lys Ala Glu Gln Tyr Gln Lys Lys Asn Arg Lys Met Leu Val
290 295 300
Ile Leu Ile Leu Phe Val Ile Ile Ile Val Leu Ile Val Val Leu Val
305 310 315 320
Gly Val Lys Ser Arg
325
<210> 183
<211> 118
<212> PRT
<213> 人类
<400> 183
Met Ser Ala Pro Ala Gln Pro Pro Ala Glu Gly Thr Glu Gly Thr Ala
1 5 10 15
Pro Gly Gly Gly Pro Pro Gly Pro Pro Pro Asn Met Thr Ser Asn Arg
20 25 30
Arg Leu Gln Gln Thr Gln Ala Gln Val Glu Glu Val Val Asp Ile Ile
35 40 45
Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu
50 55 60
Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu
65 70 75 80
Ser Ser Ala Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Cys Lys
85 90 95
Met Met Ile Met Leu Gly Ala Ile Cys Ala Ile Ile Val Val Val Ile
100 105 110
Val Ile Tyr Phe Phe Thr
115
<210> 184
<211> 335
<212> PRT
<213> 人类
<400> 184
Met Ala Val Asp Ile Thr Leu Leu Phe Arg Ala Ser Val Lys Thr Val
1 5 10 15
Lys Thr Arg Asn Lys Ala Leu Gly Val Ala Val Gly Gly Gly Val Asp
20 25 30
Gly Ser Arg Asp Glu Leu Phe Arg Arg Ser Pro Arg Pro Lys Gly Asp
35 40 45
Phe Ser Ser Arg Ala Arg Glu Val Ile Ser His Ile Gly Lys Leu Arg
50 55 60
Asp Phe Leu Leu Glu His Arg Lys Asp Tyr Ile Asn Ala Tyr Ser His
65 70 75 80
Thr Met Ser Glu Tyr Gly Arg Met Thr Asp Thr Glu Arg Asp Gln Ile
85 90 95
Asp Gln Asp Ala Gln Ile Phe Met Arg Thr Cys Ser Glu Ala Ile Gln
100 105 110
Gln Leu Arg Thr Glu Ala His Lys Glu Ile His Ser Gln Gln Val Lys
115 120 125
Glu His Arg Thr Ala Val Leu Asp Phe Ile Glu Asp Tyr Leu Lys Arg
130 135 140
Val Cys Lys Leu Tyr Ser Glu Gln Arg Ala Ile Arg Val Lys Arg Val
145 150 155 160
Val Asp Lys Lys Arg Leu Ser Lys Leu Glu Pro Glu Pro Asn Thr Lys
165 170 175
Thr Arg Glu Ser Thr Ser Ser Glu Lys Val Ser Gln Ser Pro Ser Lys
180 185 190
Asp Ser Glu Glu Asn Pro Ala Thr Glu Glu Arg Pro Glu Lys Ile Leu
195 200 205
Ala Glu Thr Gln Pro Glu Leu Gly Thr Trp Gly Asp Gly Lys Gly Glu
210 215 220
Asp Glu Leu Ser Pro Glu Glu Ile Gln Met Phe Glu Gln Glu Asn Gln
225 230 235 240
Arg Leu Ile Gly Glu Met Asn Ser Leu Phe Asp Glu Val Arg Gln Ile
245 250 255
Glu Gly Arg Val Val Glu Ile Ser Arg Leu Gln Glu Ile Phe Thr Glu
260 265 270
Lys Val Leu Gln Gln Glu Ala Glu Ile Asp Ser Ile His Gln Leu Val
275 280 285
Val Gly Ala Thr Glu Asn Ile Lys Glu Gly Asn Glu Asp Ile Arg Glu
290 295 300
Ala Ile Lys Asn Asn Ala Gly Phe Arg Val Trp Ile Leu Phe Phe Leu
305 310 315 320
Val Met Cys Ser Phe Ser Leu Leu Phe Leu Asp Trp Tyr Asp Ser
325 330 335
<210> 185
<211> 287
<212> PRT
<213> 人类
<400> 185
Met Arg Asp Arg Leu Pro Asp Leu Thr Ala Cys Arg Lys Asn Asp Asp
1 5 10 15
Gly Asp Thr Val Val Val Val Glu Lys Asp His Phe Met Asp Asp Phe
20 25 30
Phe His Gln Val Glu Glu Ile Arg Asn Ser Ile Asp Lys Ile Thr Gln
35 40 45
Tyr Val Glu Glu Val Lys Lys Asn His Ser Ile Ile Leu Ser Ala Pro
50 55 60
Asn Pro Glu Gly Lys Ile Lys Glu Glu Leu Glu Asp Leu Asn Lys Glu
65 70 75 80
Ile Lys Lys Thr Ala Asn Lys Ile Arg Ala Lys Leu Lys Ala Ile Glu
85 90 95
Gln Ser Phe Asp Gln Asp Glu Ser Gly Asn Arg Thr Ser Val Asp Leu
100 105 110
Arg Ile Arg Arg Thr Gln His Ser Val Leu Ser Arg Lys Phe Val Glu
115 120 125
Ala Met Ala Glu Tyr Asn Glu Ala Gln Thr Leu Phe Arg Glu Arg Ser
130 135 140
Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Arg Thr Thr Thr
145 150 155 160
Asp Asp Glu Leu Glu Glu Met Leu Glu Ser Gly Lys Pro Ser Ile Phe
165 170 175
Thr Ser Asp Ile Ile Ser Asp Ser Gln Ile Thr Arg Gln Ala Leu Asn
180 185 190
Glu Ile Glu Ser Arg His Lys Asp Ile Met Lys Leu Glu Thr Ser Ile
195 200 205
Arg Glu Leu His Glu Met Phe Met Asp Met Ala Met Phe Val Glu Thr
210 215 220
Gln Gly Glu Met Ile Asn Asn Ile Glu Arg Asn Val Met Asn Ala Thr
225 230 235 240
Asp Tyr Val Glu His Ala Lys Glu Glu Thr Lys Lys Ala Ile Lys Tyr
245 250 255
Gln Ser Lys Ala Arg Arg Lys Leu Met Phe Ile Ile Ile Cys Val Ile
260 265 270
Val Leu Leu Val Ile Leu Gly Ile Ile Leu Ala Thr Thr Leu Ser
275 280 285
<210> 186
<211> 289
<212> PRT
<213> 人类
<400> 186
Met Lys Asp Arg Leu Glu Gln Leu Lys Ala Lys Gln Leu Thr Gln Asp
1 5 10 15
Asp Asp Thr Asp Ala Val Glu Ile Ala Ile Asp Asn Thr Ala Phe Met
20 25 30
Asp Glu Phe Phe Ser Glu Ile Glu Glu Thr Arg Leu Asn Ile Asp Lys
35 40 45
Ile Ser Glu His Val Glu Glu Ala Lys Lys Leu Tyr Ser Ile Ile Leu
50 55 60
Ser Ala Pro Ile Pro Glu Pro Lys Thr Lys Asp Asp Leu Glu Gln Leu
65 70 75 80
Thr Thr Glu Ile Lys Lys Arg Ala Asn Asn Val Arg Asn Lys Leu Lys
85 90 95
Ser Met Glu Lys His Ile Glu Glu Asp Glu Val Arg Ser Ser Ala Asp
100 105 110
Leu Arg Ile Arg Lys Ser Gln His Ser Val Leu Ser Arg Lys Phe Val
115 120 125
Glu Val Met Thr Lys Tyr Asn Glu Ala Gln Val Asp Phe Arg Glu Arg
130 135 140
Ser Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Lys Lys Thr
145 150 155 160
Thr Asp Glu Glu Leu Glu Glu Met Leu Glu Ser Gly Asn Pro Ala Ile
165 170 175
Phe Thr Ser Gly Ile Ile Asp Ser Gln Ile Ser Lys Gln Ala Leu Ser
180 185 190
Glu Ile Glu Gly Arg His Lys Asp Ile Val Arg Leu Glu Ser Ser Ile
195 200 205
Lys Glu Leu His Asp Met Phe Met Asp Ile Ala Met Leu Val Glu Asn
210 215 220
Gln Gly Glu Met Leu Asp Asn Ile Glu Leu Asn Val Met His Thr Val
225 230 235 240
Asp His Val Glu Lys Ala Arg Asp Glu Thr Lys Lys Ala Val Lys Tyr
245 250 255
Gln Ser Gln Ala Arg Lys Lys Leu Ile Ile Ile Ile Val Leu Val Val
260 265 270
Val Leu Leu Gly Ile Leu Ala Leu Ile Ile Gly Leu Ser Val Gly Leu
275 280 285
Asn
<210> 187
<211> 1115
<212> PRT
<213> 人类
<400> 187
Met Arg Lys Phe Asn Ile Arg Lys Val Leu Asp Gly Leu Thr Ala Gly
1 5 10 15
Ser Ser Ser Ala Ser Gln Gln Gln Gln Gln Gln His Pro Pro Gly Asn
20 25 30
Arg Glu Pro Glu Ile Gln Glu Thr Leu Gln Ser Glu His Phe Gln Leu
35 40 45
Cys Lys Thr Val Arg His Gly Phe Pro Tyr Gln Pro Ser Ala Leu Ala
50 55 60
Phe Asp Pro Val Gln Lys Ile Leu Ala Val Gly Thr Gln Thr Gly Ala
65 70 75 80
Leu Arg Leu Phe Gly Arg Pro Gly Val Glu Cys Tyr Cys Gln His Asp
85 90 95
Ser Gly Ala Ala Val Ile Gln Leu Gln Phe Leu Ile Asn Glu Gly Ala
100 105 110
Leu Val Ser Ala Leu Ala Asp Asp Thr Leu His Leu Trp Asn Leu Arg
115 120 125
Gln Lys Arg Pro Ala Ile Leu His Ser Leu Lys Phe Cys Arg Glu Arg
130 135 140
Val Thr Phe Cys His Leu Pro Phe Gln Ser Lys Trp Leu Tyr Val Gly
145 150 155 160
Thr Glu Arg Gly Asn Ile His Ile Val Asn Val Glu Ser Phe Thr Leu
165 170 175
Ser Gly Tyr Val Ile Met Trp Asn Lys Ala Ile Glu Leu Ser Ser Lys
180 185 190
Ser His Pro Gly Pro Val Val His Ile Ser Asp Asn Pro Met Asp Glu
195 200 205
Gly Lys Leu Leu Ile Gly Phe Glu Ser Gly Thr Val Val Leu Trp Asp
210 215 220
Leu Lys Ser Lys Lys Ala Asp Tyr Arg Tyr Thr Tyr Asp Glu Ala Ile
225 230 235 240
His Ser Val Ala Trp His His Glu Gly Lys Gln Phe Ile Cys Ser His
245 250 255
Ser Asp Gly Thr Leu Thr Ile Trp Asn Val Arg Ser Pro Ala Lys Pro
260 265 270
Val Gln Thr Ile Thr Pro His Gly Lys Gln Leu Lys Asp Gly Lys Lys
275 280 285
Pro Glu Pro Cys Lys Pro Ile Leu Lys Val Glu Phe Lys Thr Thr Arg
290 295 300
Ser Gly Glu Pro Phe Ile Ile Leu Ser Gly Gly Leu Ser Tyr Asp Thr
305 310 315 320
Val Gly Arg Arg Pro Cys Leu Thr Val Met His Gly Lys Ser Thr Ala
325 330 335
Val Leu Glu Met Asp Tyr Ser Ile Val Asp Phe Leu Thr Leu Cys Glu
340 345 350
Thr Pro Tyr Pro Asn Asp Phe Gln Glu Pro Tyr Ala Val Val Val Leu
355 360 365
Leu Glu Lys Asp Leu Val Leu Ile Asp Leu Ala Gln Asn Gly Tyr Pro
370 375 380
Ile Phe Glu Asn Pro Tyr Pro Leu Ser Ile His Glu Ser Pro Val Thr
385 390 395 400
Cys Cys Glu Tyr Phe Ala Asp Cys Pro Val Asp Leu Ile Pro Ala Leu
405 410 415
Tyr Ser Val Gly Ala Arg Gln Lys Arg Gln Gly Tyr Ser Lys Lys Glu
420 425 430
Trp Pro Ile Ser Gly Gly Asn Trp Gly Leu Gly Ala Gln Ser Tyr Pro
435 440 445
Glu Ile Ile Ile Thr Gly His Ala Asp Gly Ser Val Lys Phe Trp Asp
450 455 460
Ala Ser Ala Ile Thr Leu Gln Val Leu Tyr Lys Leu Lys Thr Ser Lys
465 470 475 480
Val Phe Glu Lys Ser Arg Asn Lys Asp Asp Arg Pro Asn Thr Asp Ile
485 490 495
Val Asp Glu Asp Pro Tyr Ala Ile Gln Ile Ile Ser Trp Cys Pro Glu
500 505 510
Ser Arg Met Leu Cys Ile Ala Gly Val Ser Ala His Val Ile Ile Tyr
515 520 525
Arg Phe Ser Lys Gln Glu Val Ile Thr Glu Val Ile Pro Met Leu Glu
530 535 540
Val Arg Leu Leu Tyr Glu Ile Asn Asp Val Glu Thr Pro Glu Gly Glu
545 550 555 560
Gln Pro Pro Pro Leu Pro Thr Pro Val Gly Gly Ser Asn Pro Gln Pro
565 570 575
Ile Pro Pro Gln Ser His Pro Ser Thr Ser Ser Ser Ser Ser Asp Gly
580 585 590
Leu Arg Asp Asn Val Pro Cys Leu Lys Val Lys Asn Ser Pro Leu Lys
595 600 605
Gln Ser Pro Gly Tyr Gln Thr Glu Leu Val Ile Gln Leu Val Trp Val
610 615 620
Gly Gly Glu Pro Pro Gln Gln Ile Thr Ser Leu Ala Val Asn Ser Ser
625 630 635 640
Tyr Gly Leu Val Val Phe Gly Asn Cys Asn Gly Ile Ala Met Val Asp
645 650 655
Tyr Leu Gln Lys Ala Val Leu Leu Asn Leu Gly Thr Ile Glu Leu Tyr
660 665 670
Gly Ser Asn Asp Pro Tyr Arg Arg Glu Pro Arg Ser Pro Arg Lys Ser
675 680 685
Arg Gln Pro Ser Gly Ala Gly Leu Cys Asp Ile Ser Glu Gly Thr Val
690 695 700
Val Pro Glu Asp Arg Cys Lys Ser Pro Thr Ser Ala Lys Met Ser Arg
705 710 715 720
Lys Leu Ser Leu Pro Thr Asp Leu Lys Pro Asp Leu Asp Val Lys Asp
725 730 735
Asn Ser Phe Ser Arg Ser Arg Ser Ser Ser Val Thr Ser Ile Asp Lys
740 745 750
Glu Ser Arg Glu Ala Ile Ser Ala Leu His Phe Cys Glu Thr Phe Thr
755 760 765
Arg Lys Thr Asp Ser Ser Pro Ser Pro Cys Leu Trp Val Gly Thr Thr
770 775 780
Leu Gly Thr Val Leu Val Ile Ala Leu Asn Leu Pro Pro Gly Gly Glu
785 790 795 800
Gln Arg Leu Leu Gln Pro Val Ile Val Ser Pro Ser Gly Thr Ile Leu
805 810 815
Arg Leu Lys Gly Ala Ile Leu Arg Met Ala Phe Leu Asp Thr Thr Gly
820 825 830
Cys Leu Ile Pro Pro Ala Tyr Glu Pro Trp Arg Glu His Asn Val Pro
835 840 845
Glu Glu Lys Asp Glu Lys Glu Lys Leu Lys Lys Arg Arg Pro Val Ser
850 855 860
Val Ser Pro Ser Ser Ser Gln Glu Ile Ser Glu Asn Gln Tyr Ala Val
865 870 875 880
Ile Cys Ser Glu Lys Gln Ala Lys Val Ile Ser Leu Pro Thr Gln Asn
885 890 895
Cys Ala Tyr Lys Gln Asn Ile Thr Glu Thr Ser Phe Val Leu Arg Gly
900 905 910
Asp Ile Val Ala Leu Ser Asn Ser Ile Cys Leu Ala Cys Phe Cys Ala
915 920 925
Asn Gly His Ile Met Thr Phe Ser Leu Pro Ser Leu Arg Pro Leu Leu
930 935 940
Asp Val Tyr Tyr Leu Pro Leu Thr Asn Met Arg Ile Ala Arg Thr Phe
945 950 955 960
Cys Phe Thr Asn Asn Gly Gln Ala Leu Tyr Leu Val Ser Pro Thr Glu
965 970 975
Ile Gln Arg Leu Thr Tyr Ser Gln Glu Thr Cys Glu Asn Leu Gln Glu
980 985 990
Met Leu Gly Glu Leu Phe Thr Pro Val Glu Thr Pro Glu Ala Pro Asn
995 1000 1005
Arg Gly Phe Phe Lys Gly Leu Phe Gly Gly Gly Ala Gln Ser Leu
1010 1015 1020
Asp Arg Glu Glu Leu Phe Gly Glu Ser Ser Ser Gly Lys Ala Ser
1025 1030 1035
Arg Ser Leu Ala Gln His Ile Pro Gly Pro Gly Gly Ile Glu Gly
1040 1045 1050
Val Lys Gly Ala Ala Ser Gly Val Val Gly Glu Leu Ala Arg Ala
1055 1060 1065
Arg Leu Ala Leu Asp Glu Arg Gly Gln Lys Leu Gly Asp Leu Glu
1070 1075 1080
Glu Arg Thr Ala Ala Met Leu Ser Ser Ala Glu Ser Phe Ser Lys
1085 1090 1095
His Ala His Glu Ile Met Leu Lys Tyr Lys Asp Lys Lys Trp Tyr
1100 1105 1110
Gln Phe
1115
<210> 188
<211> 158
<212> PRT
<213> 人类
<400> 188
Met Asp Asn Leu Ser Ser Glu Glu Ile Gln Gln Arg Ala His Gln Ile
1 5 10 15
Thr Asp Glu Ser Leu Glu Ser Thr Arg Arg Ile Leu Gly Leu Ala Ile
20 25 30
Glu Ser Gln Asp Ala Gly Ile Lys Thr Ile Thr Met Leu Asp Glu Gln
35 40 45
Lys Glu Gln Leu Asn Arg Ile Glu Glu Gly Leu Asp Gln Ile Asn Lys
50 55 60
Asp Met Arg Glu Thr Glu Lys Thr Leu Thr Glu Leu Asn Lys Cys Cys
65 70 75 80
Gly Leu Cys Val Cys Pro Cys Asn Ser Ile Thr Asn Asp Ala Arg Glu
85 90 95
Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile Leu Gly Asn
100 105 110
Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp Ala Gln Asn
115 120 125
Pro Gln Ile Lys Arg Ile Thr Asp Lys Ala Asp Thr Asn Arg Asp Arg
130 135 140
Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp Ser
145 150 155
<210> 189
<211> 249
<212> PRT
<213> 人类
<400> 189
Met Ser Leu Glu Asp Pro Phe Phe Val Val Arg Gly Glu Val Gln Lys
1 5 10 15
Ala Val Asn Thr Ala Arg Gly Leu Tyr Gln Arg Trp Cys Glu Leu Leu
20 25 30
Gln Glu Ser Ala Ala Val Gly Arg Glu Glu Leu Asp Trp Thr Thr Asn
35 40 45
Glu Leu Arg Asn Gly Leu Arg Ser Ile Glu Trp Asp Leu Glu Asp Leu
50 55 60
Glu Glu Thr Ile Gly Ile Val Glu Ala Asn Pro Gly Lys Phe Lys Leu
65 70 75 80
Pro Ala Gly Asp Leu Gln Glu Arg Lys Val Phe Val Glu Arg Met Arg
85 90 95
Glu Ala Val Gln Glu Met Lys Asp His Met Val Ser Pro Thr Ala Val
100 105 110
Ala Phe Leu Glu Arg Asn Asn Arg Glu Ile Leu Ala Gly Lys Pro Ala
115 120 125
Ala Gln Lys Ser Pro Ser Asp Leu Leu Asp Ala Ser Ala Val Ser Ala
130 135 140
Thr Ser Arg Tyr Ile Glu Glu Gln Gln Ala Thr Gln Gln Leu Ile Met
145 150 155 160
Asp Glu Gln Asp Gln Gln Leu Glu Met Val Ser Gly Ser Ile Gln Val
165 170 175
Leu Lys His Met Ser Gly Arg Val Gly Glu Glu Leu Asp Glu Gln Gly
180 185 190
Ile Met Leu Asp Ala Phe Ala Gln Glu Met Asp His Thr Gln Ser Arg
195 200 205
Met Asp Gly Val Leu Arg Lys Leu Ala Lys Val Ser His Met Thr Ser
210 215 220
Asp Arg Arg Gln Trp Cys Ala Ile Ala Val Leu Val Gly Val Leu Leu
225 230 235 240
Leu Val Leu Ile Leu Leu Phe Ser Leu
245
<210> 190
<211> 355
<212> PRT
<213> 人类
<400> 190
Met Ile Pro Arg Lys Arg Tyr Gly Ser Lys Asn Thr Asp Gln Gly Val
1 5 10 15
Tyr Leu Gly Leu Ser Lys Thr Gln Val Leu Ser Pro Ala Thr Ala Gly
20 25 30
Ser Ser Ser Ser Asp Ile Ala Pro Leu Pro Pro Pro Val Thr Leu Val
35 40 45
Pro Pro Pro Pro Asp Thr Met Ser Cys Arg Asp Arg Thr Gln Glu Phe
50 55 60
Leu Ser Ala Cys Lys Ser Leu Gln Thr Arg Gln Asn Gly Ile Gln Thr
65 70 75 80
Asn Lys Pro Ala Leu Arg Ala Val Arg Gln Arg Ser Glu Phe Thr Leu
85 90 95
Met Ala Lys Arg Ile Gly Lys Asp Leu Ser Asn Thr Phe Ala Lys Leu
100 105 110
Glu Lys Leu Thr Ile Leu Ala Lys Arg Lys Ser Leu Phe Asp Asp Lys
115 120 125
Ala Val Glu Ile Glu Glu Leu Thr Tyr Ile Ile Lys Gln Asp Ile Asn
130 135 140
Ser Leu Asn Lys Gln Ile Ala Gln Leu Gln Asp Phe Val Arg Ala Lys
145 150 155 160
Gly Ser Gln Ser Gly Arg His Leu Gln Thr His Ser Asn Thr Ile Val
165 170 175
Val Ser Leu Gln Ser Lys Leu Ala Ser Met Ser Asn Asp Phe Lys Ser
180 185 190
Val Leu Glu Val Arg Thr Glu Asn Leu Lys Gln Gln Arg Ser Arg Arg
195 200 205
Glu Gln Phe Ser Arg Ala Pro Val Ser Ala Leu Pro Leu Ala Pro Asn
210 215 220
His Leu Gly Gly Gly Ala Val Val Leu Gly Ala Glu Ser His Ala Ser
225 230 235 240
Lys Asp Val Ala Ile Asp Met Met Asp Ser Arg Thr Ser Gln Gln Leu
245 250 255
Gln Leu Ile Asp Glu Gln Asp Ser Tyr Ile Gln Ser Arg Ala Asp Thr
260 265 270
Met Gln Asn Ile Glu Ser Thr Ile Val Glu Leu Gly Ser Ile Phe Gln
275 280 285
Gln Leu Ala His Met Val Lys Glu Gln Glu Glu Thr Ile Gln Arg Ile
290 295 300
Asp Glu Asn Val Leu Gly Ala Gln Leu Asp Val Glu Ala Ala His Ser
305 310 315 320
Glu Ile Leu Lys Tyr Phe Gln Ser Val Thr Ser Asn Arg Trp Leu Met
325 330 335
Val Lys Ile Phe Leu Ile Leu Ile Val Phe Phe Ile Ile Phe Val Val
340 345 350
Phe Leu Ala
355
<210> 191
<211> 462
<212> PRT
<213> 人类
<400> 191
Met Ser Ala Gly Gly Pro Cys Pro Ala Ala Ala Gly Gly Gly Pro Gly
1 5 10 15
Gly Ala Ser Cys Ser Val Gly Ala Pro Gly Gly Val Ser Met Phe Arg
20 25 30
Trp Leu Glu Val Leu Glu Lys Glu Phe Asp Lys Ala Phe Val Asp Val
35 40 45
Asp Leu Leu Leu Gly Glu Ile Asp Pro Asp Gln Ala Asp Ile Thr Tyr
50 55 60
Glu Gly Arg Gln Lys Met Thr Ser Leu Ser Ser Cys Phe Ala Gln Leu
65 70 75 80
Cys His Lys Ala Gln Ser Val Ser Gln Ile Asn His Lys Leu Glu Ala
85 90 95
Gln Leu Val Asp Leu Lys Ser Glu Leu Thr Glu Thr Gln Ala Glu Lys
100 105 110
Val Val Leu Glu Lys Glu Val His Asp Gln Leu Leu Gln Leu His Ser
115 120 125
Ile Gln Leu Gln Leu His Ala Lys Thr Gly Gln Ser Ala Asp Ser Gly
130 135 140
Thr Ile Lys Ala Lys Leu Ser Gly Pro Ser Val Glu Glu Leu Glu Arg
145 150 155 160
Glu Leu Glu Ala Asn Lys Lys Glu Lys Met Lys Glu Ala Gln Leu Glu
165 170 175
Ala Glu Val Lys Leu Leu Arg Lys Glu Asn Glu Ala Leu Arg Arg His
180 185 190
Ile Ala Val Leu Gln Ala Glu Val Tyr Gly Ala Arg Leu Ala Ala Lys
195 200 205
Tyr Leu Asp Lys Glu Leu Ala Gly Arg Val Gln Gln Ile Gln Leu Leu
210 215 220
Gly Arg Asp Met Lys Gly Pro Ala His Asp Lys Leu Trp Asn Gln Leu
225 230 235 240
Glu Ala Glu Ile His Leu His Arg His Lys Thr Val Ile Arg Ala Cys
245 250 255
Arg Gly Arg Asn Asp Leu Lys Arg Pro Met Gln Ala Pro Pro Gly His
260 265 270
Asp Gln Asp Ser Leu Lys Lys Ser Gln Gly Val Gly Pro Ile Arg Lys
275 280 285
Val Leu Leu Leu Lys Glu Asp His Glu Gly Leu Gly Ile Ser Ile Thr
290 295 300
Gly Gly Lys Glu His Gly Val Pro Ile Leu Ile Ser Glu Ile His Pro
305 310 315 320
Gly Gln Pro Ala Asp Arg Cys Gly Gly Leu His Val Gly Asp Ala Ile
325 330 335
Leu Ala Val Asn Gly Val Asn Leu Arg Asp Thr Lys His Lys Glu Ala
340 345 350
Val Thr Ile Leu Ser Gln Gln Arg Gly Glu Ile Glu Phe Glu Val Val
355 360 365
Tyr Val Ala Pro Glu Val Asp Ser Asp Asp Glu Asn Val Glu Tyr Glu
370 375 380
Asp Glu Ser Gly His Arg Tyr Arg Leu Tyr Leu Asp Glu Leu Glu Gly
385 390 395 400
Gly Gly Asn Pro Gly Ala Ser Cys Lys Asp Thr Ser Gly Glu Ile Lys
405 410 415
Val Leu Gln Gly Phe Asn Lys Lys Ala Val Thr Asp Thr His Glu Asn
420 425 430
Gly Asp Leu Gly Thr Ala Ser Glu Thr Pro Leu Asp Asp Gly Ala Ser
435 440 445
Lys Leu Asp Asp Leu His Thr Leu Tyr His Lys Lys Ser Tyr
450 455 460
<210> 192
<211> 212
<212> PRT
<213> 人类
<400> 192
Met Asp Pro Leu Phe Gln Gln Thr His Lys Gln Val His Glu Ile Gln
1 5 10 15
Ser Cys Met Gly Arg Leu Glu Thr Ala Asp Lys Gln Ser Val His Ile
20 25 30
Val Glu Asn Glu Ile Gln Ala Ser Ile Asp Gln Ile Phe Ser Arg Leu
35 40 45
Glu Arg Leu Glu Ile Leu Ser Ser Lys Glu Pro Pro Asn Lys Arg Gln
50 55 60
Asn Ala Arg Leu Arg Val Asp Gln Leu Lys Tyr Asp Val Gln His Leu
65 70 75 80
Gln Thr Ala Leu Arg Asn Phe Gln His Arg Arg His Ala Arg Glu Gln
85 90 95
Gln Glu Arg Gln Arg Glu Glu Leu Leu Ser Arg Thr Phe Thr Thr Asn
100 105 110
Asp Ser Asp Thr Thr Ile Pro Met Asp Glu Ser Leu Gln Phe Asn Ser
115 120 125
Ser Leu Gln Lys Val His Asn Gly Met Asp Asp Leu Ile Leu Asp Gly
130 135 140
His Asn Ile Leu Asp Gly Leu Arg Thr Gln Arg Leu Thr Leu Lys Gly
145 150 155 160
Thr Gln Lys Lys Ile Leu Asp Ile Ala Asn Met Leu Gly Leu Ser Asn
165 170 175
Thr Val Met Arg Leu Ile Glu Lys Arg Ala Phe Gln Asp Lys Tyr Phe
180 185 190
Met Ile Gly Gly Met Leu Leu Thr Cys Val Val Met Phe Leu Val Val
195 200 205
Gln Tyr Leu Thr
210
<210> 193
<211> 213
<212> PRT
<213> 人类
<400> 193
Met Asp Pro Leu Phe Gln Gln Thr His Lys Gln Val His Glu Ile Gln
1 5 10 15
Ser Cys Met Gly Arg Leu Glu Thr Ala Asp Lys Gln Ser Val His Ile
20 25 30
Val Glu Asn Glu Ile Gln Ala Ser Ile Asp Gln Ile Phe Ser Arg Leu
35 40 45
Glu Arg Leu Glu Ile Leu Ser Ser Lys Glu Pro Pro Asn Lys Arg Gln
50 55 60
Asn Ala Arg Leu Arg Val Asp Gln Leu Lys Tyr Asp Val Gln His Leu
65 70 75 80
Gln Thr Ala Leu Arg Asn Phe Gln His Arg Arg His Ala Arg Glu Gln
85 90 95
Gln Glu Arg Gln Arg Glu Glu Leu Leu Ser Arg Thr Phe Thr Thr Asn
100 105 110
Asp Ser Asp Thr Thr Ile Pro Met Asp Glu Ser Leu Gln Phe Asn Ser
115 120 125
Ser Leu Gln Lys Val His Asn Gly Met Asp Asp Leu Ile Leu Asp Gly
130 135 140
His Asn Ile Leu Asp Gly Leu Arg Thr Gln Arg Leu Thr Leu Lys Gly
145 150 155 160
Thr Gln Lys Lys Ile Leu Asp Ile Ala Asn Met Leu Gly Leu Ser Asn
165 170 175
Thr Val Met Arg Leu Ile Glu Lys Arg Ala Phe Gln Asp Lys Tyr Phe
180 185 190
Met Ile Gly Thr Gln Gly Ser Cys Gln Thr Ala His Phe Gly Gly Arg
195 200 205
Ser Ala Gly Ser Ser
210
<210> 194
<211> 255
<212> PRT
<213> 人类
<400> 194
Met Ser Met Glu Asp Pro Phe Phe Val Val Lys Gly Glu Val Gln Lys
1 5 10 15
Ala Val Asn Thr Ala Gln Gly Leu Phe Gln Arg Trp Thr Glu Leu Leu
20 25 30
Gln Asp Pro Ser Thr Ala Thr Arg Glu Glu Ile Asp Trp Thr Thr Asn
35 40 45
Glu Leu Arg Asn Asn Leu Arg Ser Ile Glu Trp Asp Leu Glu Asp Leu
50 55 60
Asp Glu Thr Ile Ser Ile Val Glu Ala Asn Pro Arg Lys Phe Asn Leu
65 70 75 80
Asp Ala Thr Glu Leu Ser Ile Arg Lys Ala Phe Ile Thr Ser Thr Arg
85 90 95
Gln Val Val Arg Asp Met Lys Asp Gln Met Ser Thr Ser Ser Val Gln
100 105 110
Ala Leu Ala Glu Arg Lys Asn Arg Gln Ala Leu Leu Gly Asp Ser Gly
115 120 125
Ser Gln Asn Trp Ser Thr Gly Thr Thr Asp Lys Tyr Gly Arg Leu Asp
130 135 140
Arg Glu Leu Gln Arg Ala Asn Ser His Phe Ile Glu Glu Gln Gln Ala
145 150 155 160
Gln Gln Gln Leu Ile Val Glu Gln Gln Asp Glu Gln Leu Glu Leu Val
165 170 175
Ser Gly Ser Ile Gly Val Leu Lys Asn Met Ser Gln Arg Ile Gly Gly
180 185 190
Glu Leu Glu Glu Gln Ala Val Met Leu Glu Asp Phe Ser His Glu Leu
195 200 205
Glu Ser Thr Gln Ser Arg Leu Asp Asn Val Met Lys Lys Leu Ala Lys
210 215 220
Val Ser His Met Thr Ser Asp Arg Arg Gln Trp Cys Ala Ile Ala Ile
225 230 235 240
Leu Phe Ala Val Leu Leu Val Val Leu Ile Leu Phe Leu Val Leu
245 250 255
<210> 195
<211> 250
<212> PRT
<213> 人类
<400> 195
Met Ala Ala Gly Thr Ser Ser Tyr Trp Glu Asp Leu Arg Lys Gln Ala
1 5 10 15
Arg Gln Leu Glu Asn Glu Leu Asp Leu Lys Leu Val Ser Phe Ser Lys
20 25 30
Leu Cys Thr Ser Tyr Ser His Ser Ser Thr Arg Asp Gly Arg Arg Asp
35 40 45
Arg Tyr Ser Ser Asp Thr Thr Pro Leu Leu Asn Gly Ser Ser Gln Asp
50 55 60
Arg Met Phe Glu Thr Met Ala Ile Glu Ile Glu Gln Leu Leu Ala Arg
65 70 75 80
Leu Thr Gly Val Asn Asp Lys Met Ala Glu Tyr Thr Asn Ser Ala Gly
85 90 95
Val Pro Ser Leu Asn Ala Ala Leu Met His Thr Leu Gln Arg His Arg
100 105 110
Asp Ile Leu Gln Asp Tyr Thr His Glu Phe His Lys Thr Lys Ala Asn
115 120 125
Phe Met Ala Ile Arg Glu Arg Glu Asn Leu Met Gly Ser Val Arg Lys
130 135 140
Asp Ile Glu Ser Tyr Lys Ser Gly Ser Gly Val Asn Asn Arg Arg Thr
145 150 155 160
Glu Leu Phe Leu Lys Glu His Asp His Leu Arg Asn Ser Asp Arg Leu
165 170 175
Ile Glu Glu Thr Ile Ser Ile Ala Met Ala Thr Lys Glu Asn Met Thr
180 185 190
Ser Gln Arg Gly Met Leu Lys Ser Ile His Ser Lys Met Asn Thr Leu
195 200 205
Ala Asn Arg Phe Pro Ala Val Asn Ser Leu Ile Gln Arg Ile Asn Leu
210 215 220
Arg Lys Arg Arg Asp Ser Leu Ile Leu Gly Gly Val Ile Gly Ile Cys
225 230 235 240
Thr Ile Leu Leu Leu Leu Tyr Ala Phe His
245 250
<210> 196
<211> 294
<212> PRT
<213> 人类
<400> 196
Met Lys Asp Arg Leu Gln Glu Leu Lys Gln Arg Thr Lys Glu Ile Glu
1 5 10 15
Leu Ser Arg Asp Ser His Val Ser Thr Thr Glu Thr Glu Glu Gln Gly
20 25 30
Val Phe Leu Gln Gln Ala Val Ile Tyr Glu Arg Glu Pro Val Ala Glu
35 40 45
Arg His Leu His Glu Ile Gln Lys Leu Gln Glu Ser Ile Asn Asn Leu
50 55 60
Ala Asp Asn Val Gln Lys Phe Gly Gln Gln Gln Lys Ser Leu Val Ala
65 70 75 80
Ser Met Arg Arg Phe Ser Leu Leu Lys Arg Glu Ser Thr Ile Thr Lys
85 90 95
Glu Ile Lys Ile Gln Ala Glu Tyr Ile Asn Arg Ser Leu Asn Asp Leu
100 105 110
Val Lys Glu Val Lys Lys Ser Glu Val Glu Asn Gly Pro Ser Ser Val
115 120 125
Val Thr Arg Ile Leu Lys Ser Gln His Ala Ala Met Phe Arg His Phe
130 135 140
Gln Gln Ile Met Phe Ile Tyr Asn Asp Thr Ile Ala Ala Lys Gln Glu
145 150 155 160
Lys Cys Lys Thr Phe Ile Leu Arg Gln Leu Glu Val Ala Gly Lys Glu
165 170 175
Met Ser Glu Glu Asp Val Asn Asp Met Leu His Gln Gly Lys Trp Glu
180 185 190
Val Phe Asn Glu Ser Leu Leu Thr Glu Ile Asn Ile Thr Lys Ala Gln
195 200 205
Leu Ser Glu Ile Glu Gln Arg His Lys Glu Leu Val Asn Leu Glu Asn
210 215 220
Gln Ile Lys Asp Leu Arg Asp Leu Phe Ile Gln Ile Ser Leu Leu Val
225 230 235 240
Glu Glu Gln Gly Glu Ser Ile Asn Asn Ile Glu Met Thr Val Asn Ser
245 250 255
Thr Lys Glu Tyr Val Asn Asn Thr Lys Glu Lys Phe Gly Leu Ala Val
260 265 270
Lys Tyr Lys Lys Arg Asn Pro Cys Arg Val Leu Cys Cys Trp Cys Cys
275 280 285
Pro Cys Cys Ser Ser Lys
290
<210> 197
<211> 304
<212> PRT
<213> 人类
<400> 197
Met Ala Thr Arg Arg Leu Thr Asp Ala Phe Leu Leu Leu Arg Asn Asn
1 5 10 15
Ser Ile Gln Asn Arg Gln Leu Leu Ala Glu Gln Leu Ala Asp Asp Arg
20 25 30
Met Ala Leu Val Ser Gly Ile Ser Leu Asp Pro Glu Ala Ala Ile Gly
35 40 45
Val Thr Lys Arg Pro Pro Pro Lys Trp Val Asp Gly Val Asp Glu Ile
50 55 60
Gln Tyr Asp Val Gly Arg Ile Lys Gln Lys Met Lys Glu Leu Ala Ser
65 70 75 80
Leu His Asp Lys His Leu Asn Arg Pro Thr Leu Asp Asp Ser Ser Glu
85 90 95
Glu Glu His Ala Ile Glu Ile Thr Thr Gln Glu Ile Thr Gln Leu Phe
100 105 110
His Arg Cys Gln Arg Ala Val Gln Ala Leu Pro Ser Arg Ala Arg Ala
115 120 125
Cys Ser Glu Gln Glu Gly Arg Leu Leu Gly Asn Val Val Ala Ser Leu
130 135 140
Ala Gln Ala Leu Gln Glu Leu Ser Thr Ser Phe Arg His Ala Gln Ser
145 150 155 160
Gly Tyr Leu Lys Arg Met Lys Asn Arg Glu Glu Arg Ser Gln His Phe
165 170 175
Phe Asp Thr Ser Val Pro Leu Met Asp Asp Gly Asp Asp Asn Thr Leu
180 185 190
Tyr His Arg Gly Phe Thr Glu Asp Gln Leu Val Leu Val Glu Gln Asn
195 200 205
Thr Leu Met Val Glu Glu Arg Glu Arg Glu Ile Arg Gln Ile Val Gln
210 215 220
Ser Ile Ser Asp Leu Asn Glu Ile Phe Arg Asp Leu Gly Ala Met Ile
225 230 235 240
Val Glu Gln Gly Thr Val Leu Asp Arg Ile Asp Tyr Asn Val Glu Gln
245 250 255
Ser Cys Ile Lys Thr Glu Asp Gly Leu Lys Gln Leu His Lys Ala Glu
260 265 270
Gln Tyr Gln Lys Lys Asn Arg Lys Met Leu Val Ile Leu Ile Leu Phe
275 280 285
Val Ile Ile Ile Val Leu Ile Val Val Leu Val Gly Val Lys Ser Arg
290 295 300
<210> 198
<211> 100
<212> PRT
<213> 人类
<400> 198
Met Ser Thr Gly Pro Thr Ala Ala Thr Gly Ser Asn Arg Arg Leu Gln
1 5 10 15
Gln Thr Gln Asn Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn
20 25 30
Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp
35 40 45
Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala
50 55 60
Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Cys Lys Met Trp Ala
65 70 75 80
Ile Gly Ile Thr Val Leu Val Ile Phe Ile Ile Ile Ile Ile Val Trp
85 90 95
Val Val Ser Ser
100
<210> 199
<211> 117
<212> PRT
<213> 人类
<400> 199
Met Ser Ala Pro Ala Gln Pro Pro Ala Glu Gly Thr Glu Gly Thr Ala
1 5 10 15
Pro Gly Gly Gly Pro Pro Gly Pro Pro Pro Asn Met Thr Ser Asn Arg
20 25 30
Arg Leu Gln Gln Thr Gln Ala Gln Val Glu Glu Val Val Asp Ile Ile
35 40 45
Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu
50 55 60
Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu
65 70 75 80
Ser Ser Ala Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Cys Lys
85 90 95
Met Met Ile Met Leu Gly Ala Ile Cys Ala Ile Ile Val Val Val Ile
100 105 110
Val Ser Lys Tyr Arg
115
<210> 200
<211> 116
<212> PRT
<213> 婆罗洲猩猩
<400> 200
Met Ser Ala Pro Ala Gln Pro Pro Ala Glu Gly Thr Glu Gly Thr Ala
1 5 10 15
Pro Gly Gly Gly Pro Pro Gly Pro Pro Pro Asn Met Thr Ser Asn Arg
20 25 30
Arg Leu Gln Gln Thr Gln Ala Gln Val Glu Glu Val Val Asp Ile Ile
35 40 45
Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu
50 55 60
Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu
65 70 75 80
Ser Ser Ala Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Cys Lys
85 90 95
Met Met Ile Met Leu Gly Ala Ile Cys Ala Ile Ile Val Val Val Ile
100 105 110
Val Arg Arg Asp
115
<210> 201
<211> 494
<212> PRT
<213> 人类
<400> 201
Met Ala Met Ser Leu Pro Gly Ser Arg Arg Thr Ser Ala Gly Ser Arg
1 5 10 15
Arg Arg Thr Ser Pro Pro Val Ser Val Arg Asp Ala Tyr Gly Thr Ser
20 25 30
Ser Leu Ser Ser Ser Ser Asn Ser Gly Ser Tyr Lys Gly Ser Asp Ser
35 40 45
Ser Pro Thr Pro Arg Arg Ser Met Lys Tyr Thr Leu Cys Ser Asp Asn
50 55 60
His Gly Ile Lys Pro Pro Thr Pro Glu Gln Tyr Leu Thr Pro Leu Gln
65 70 75 80
Gln Lys Glu Val Cys Ile Arg His Leu Lys Ala Arg Leu Lys Asp Thr
85 90 95
Gln Asp Arg Leu Gln Asp Arg Asp Thr Glu Ile Asp Asp Leu Lys Thr
100 105 110
Gln Leu Ser Arg Met Gln Glu Asp Trp Ile Glu Glu Glu Cys His Arg
115 120 125
Val Glu Ala Gln Leu Ala Leu Lys Glu Ala Arg Lys Glu Ile Lys Gln
130 135 140
Leu Lys Gln Val Ile Asp Thr Val Lys Asn Asn Leu Ile Asp Lys Asp
145 150 155 160
Lys Gly Leu Gln Lys Tyr Phe Val Asp Ile Asn Ile Gln Asn Lys Lys
165 170 175
Leu Glu Thr Leu Leu His Ser Met Glu Val Ala Gln Asn Gly Met Ala
180 185 190
Lys Glu Asp Gly Thr Gly Glu Ser Ala Gly Gly Ser Pro Ala Arg Ser
195 200 205
Leu Thr Arg Ser Ser Thr Tyr Thr Lys Leu Ser Asp Pro Ala Val Cys
210 215 220
Gly Asp Arg Gln Pro Gly Asp Pro Ser Ser Gly Ser Ala Glu Asp Gly
225 230 235 240
Ala Asp Ser Gly Phe Ala Ala Ala Asp Asp Thr Leu Ser Arg Thr Asp
245 250 255
Ala Leu Glu Ala Ser Ser Leu Leu Ser Ser Gly Val Asp Cys Gly Thr
260 265 270
Glu Glu Thr Ser Leu His Ser Ser Phe Gly Leu Gly Pro Arg Phe Pro
275 280 285
Ala Ser Asn Thr Tyr Glu Lys Leu Leu Cys Gly Met Glu Ala Gly Val
290 295 300
Gln Ala Ser Cys Met Gln Glu Arg Ala Ile Gln Thr Asp Phe Val Gln
305 310 315 320
Tyr Gln Pro Asp Leu Asp Thr Ile Leu Glu Lys Val Thr Gln Ala Gln
325 330 335
Val Cys Gly Thr Asp Pro Glu Ser Gly Asp Arg Cys Pro Glu Leu Asp
340 345 350
Ala His Pro Ser Gly Pro Arg Asp Pro Asn Ser Ala Val Val Val Thr
355 360 365
Val Gly Asp Glu Leu Glu Ala Pro Glu Pro Ile Thr Arg Gly Pro Thr
370 375 380
Pro Gln Arg Pro Gly Ala Asn Pro Asn Pro Gly Gln Ser Val Ser Val
385 390 395 400
Val Cys Pro Met Glu Glu Glu Glu Glu Ala Ala Val Ala Glu Lys Glu
405 410 415
Pro Lys Ser Tyr Trp Ser Arg His Tyr Ile Val Asp Leu Leu Ala Val
420 425 430
Val Val Pro Ala Val Pro Thr Val Ala Trp Leu Cys Arg Ser Gln Arg
435 440 445
Arg Gln Gly Gln Pro Ile Tyr Asn Ile Ser Ser Leu Leu Arg Gly Cys
450 455 460
Cys Thr Val Ala Leu His Ser Ile Arg Arg Ile Ser Cys Arg Ser Leu
465 470 475 480
Ser Gln Pro Ser Pro Ser Pro Ala Gly Gly Gly Ser Gln Leu
485 490
<210> 202
<211> 198
<212> PRT
<213> 人类
<400> 202
Met Lys Leu Tyr Ser Leu Ser Val Leu Tyr Lys Gly Glu Ala Lys Val
1 5 10 15
Val Leu Leu Lys Ala Ala Tyr Asp Val Ser Ser Phe Ser Phe Phe Gln
20 25 30
Arg Ser Ser Val Gln Glu Phe Met Thr Phe Thr Ser Gln Leu Ile Val
35 40 45
Glu Arg Ser Ser Lys Gly Thr Arg Ala Ser Val Lys Glu Gln Asp Tyr
50 55 60
Leu Cys His Val Tyr Val Arg Asn Asp Ser Leu Ala Gly Val Val Ile
65 70 75 80
Ala Asp Asn Glu Tyr Pro Ser Arg Val Ala Phe Thr Leu Leu Glu Lys
85 90 95
Val Leu Asp Glu Phe Ser Lys Gln Val Asp Arg Ile Asp Trp Pro Val
100 105 110
Gly Ser Pro Ala Thr Ile His Tyr Pro Ala Leu Asp Gly His Leu Ser
115 120 125
Arg Tyr Gln Asn Pro Arg Glu Ala Asp Pro Met Thr Lys Val Gln Ala
130 135 140
Glu Leu Asp Glu Thr Lys Ile Ile Leu His Asn Thr Met Glu Ser Leu
145 150 155 160
Leu Glu Arg Gly Glu Lys Leu Asp Asp Leu Val Ser Lys Ser Glu Val
165 170 175
Leu Gly Thr Gln Ser Lys Ala Phe Tyr Lys Thr Ala Arg Lys Gln Asn
180 185 190
Ser Cys Cys Ala Ile Met
195
<210> 203
<211> 297
<212> PRT
<213> 人类
<400> 203
Met Arg Asp Arg Thr His Glu Leu Arg Gln Gly Asp Asp Ser Ser Asp
1 5 10 15
Glu Glu Asp Lys Glu Arg Val Ala Leu Val Val His Pro Gly Thr Ala
20 25 30
Arg Leu Gly Ser Pro Asp Glu Glu Phe Phe His Lys Val Arg Thr Ile
35 40 45
Arg Gln Thr Ile Val Lys Leu Gly Asn Lys Val Gln Glu Leu Glu Lys
50 55 60
Gln Gln Val Thr Ile Leu Ala Thr Pro Leu Pro Glu Glu Ser Met Lys
65 70 75 80
Gln Glu Leu Gln Asn Leu Arg Asp Glu Ile Lys Gln Leu Gly Arg Glu
85 90 95
Ile Arg Leu Gln Leu Lys Ala Ile Glu Pro Gln Lys Glu Glu Ala Asp
100 105 110
Glu Asn Tyr Asn Ser Val Asn Thr Arg Met Arg Lys Thr Gln His Gly
115 120 125
Val Leu Ser Gln Gln Phe Val Glu Leu Ile Asn Lys Cys Asn Ser Met
130 135 140
Gln Ser Glu Tyr Arg Glu Lys Asn Val Glu Arg Ile Arg Arg Gln Leu
145 150 155 160
Lys Ile Thr Asn Ala Gly Met Val Ser Asp Glu Glu Leu Glu Gln Met
165 170 175
Leu Asp Ser Gly Gln Ser Glu Val Phe Val Ser Asn Ile Leu Lys Asp
180 185 190
Thr Gln Val Thr Arg Gln Ala Leu Asn Glu Ile Ser Ala Arg His Ser
195 200 205
Glu Ile Gln Gln Leu Glu Arg Ser Ile Arg Glu Leu His Asp Ile Phe
210 215 220
Thr Phe Leu Ala Thr Glu Val Glu Met Gln Gly Glu Met Ile Asn Arg
225 230 235 240
Ile Glu Lys Asn Ile Leu Ser Ser Ala Asp Tyr Val Glu Arg Gly Gln
245 250 255
Glu His Val Lys Thr Ala Leu Glu Asn Gln Lys Lys Ala Arg Lys Lys
260 265 270
Lys Val Leu Ile Ala Ile Cys Val Ser Ile Thr Val Val Leu Leu Ala
275 280 285
Val Ile Ile Gly Val Thr Val Val Gly
290 295
<210> 204
<211> 287
<212> PRT
<213> 人类
<400> 204
Met Lys Asp Arg Leu Ala Glu Leu Leu Asp Leu Ser Lys Gln Tyr Asp
1 5 10 15
Gln Gln Phe Pro Asp Gly Asp Asp Glu Phe Asp Ser Pro His Glu Asp
20 25 30
Ile Val Phe Glu Thr Asp His Ile Leu Glu Ser Leu Tyr Arg Asp Ile
35 40 45
Arg Asp Ile Gln Asp Glu Asn Gln Leu Leu Val Ala Asp Val Lys Arg
50 55 60
Leu Gly Lys Gln Asn Ala Arg Phe Leu Thr Ser Met Arg Arg Leu Ser
65 70 75 80
Ser Ile Lys Arg Asp Thr Asn Ser Ile Ala Lys Ala Ile Lys Ala Arg
85 90 95
Gly Glu Val Ile His Cys Lys Leu Arg Ala Met Lys Glu Leu Ser Glu
100 105 110
Ala Ala Glu Ala Gln His Gly Pro His Ser Ala Val Ala Arg Ile Ser
115 120 125
Arg Ala Gln Tyr Asn Ala Leu Thr Leu Thr Phe Gln Arg Ala Met His
130 135 140
Asp Tyr Asn Gln Ala Glu Met Lys Gln Arg Asp Asn Cys Lys Ile Arg
145 150 155 160
Ile Gln Arg Gln Leu Glu Ile Met Gly Lys Glu Val Ser Gly Asp Gln
165 170 175
Ile Glu Asp Met Phe Glu Gln Gly Lys Trp Asp Val Phe Ser Glu Asn
180 185 190
Leu Leu Ala Asp Val Lys Gly Ala Arg Ala Ala Leu Asn Glu Ile Glu
195 200 205
Ser Arg His Arg Glu Leu Leu Arg Leu Glu Ser Arg Ile Arg Asp Val
210 215 220
His Glu Leu Phe Leu Gln Met Ala Val Leu Val Glu Lys Gln Ala Asp
225 230 235 240
Thr Leu Asn Val Ile Glu Leu Asn Val Gln Lys Thr Val Asp Tyr Thr
245 250 255
Gly Gln Ala Lys Ala Gln Val Arg Lys Ala Val Gln Tyr Glu Glu Lys
260 265 270
Asn Pro Cys Arg Thr Leu Cys Cys Phe Cys Cys Pro Cys Leu Lys
275 280 285
<210> 205
<211> 513
<212> PRT
<213> 人类
<400> 205
Met Ser Tyr Gly Ser Ile Ala Arg Gly Gly Gly Leu Gly Ser Arg Gly
1 5 10 15
Pro Leu Gly Gly Pro Ser Arg Gln Gly Cys Gln Pro Leu Glu Cys Ala
20 25 30
Arg Cys Trp Thr Glu Tyr Gly Ile Arg His Phe Pro Cys Pro Ser Pro
35 40 45
Glu Ser Lys Leu Gln Asn Pro Cys Val Gly Lys Asp Gly Glu Gly Asp
50 55 60
Leu Gly Pro Ala Gly Thr Pro Ile Val Pro Arg Ala Arg Lys Arg Gly
65 70 75 80
Pro Gly Val Ala Pro Glu Gly Ser Arg Met Pro Glu Pro Thr Ser Ser
85 90 95
Pro Thr Ile Gly Pro Arg Lys Asp Ser Ala Ala Gly Pro His Gly Arg
100 105 110
Met Ala Gly Pro Ser Ala Thr Arg Ala Lys Lys Arg Lys Pro Asn Phe
115 120 125
Cys Pro Gln Glu Thr Glu Val Leu Val Ser Lys Val Ser Lys His His
130 135 140
Gln Leu Leu Phe Gly Thr Gly Leu Leu Lys Ala Glu Pro Thr Arg Arg
145 150 155 160
Tyr Arg Val Trp Ser Arg Ile Leu Gln Ala Val Asn Ala Leu Gly Tyr
165 170 175
Cys Arg Arg Asp Val Val Asp Leu Lys His Lys Trp Arg Asp Leu Arg
180 185 190
Ala Val Val Arg Arg Lys Leu Gly Asp Leu Arg Lys Ala Ala His Gly
195 200 205
Pro Ser Pro Gly Ser Gly Lys Pro Gln Ala Leu Ala Leu Thr Pro Val
210 215 220
Glu Gln Val Val Ala Lys Thr Phe Ser Cys Gln Ala Leu Pro Ser Glu
225 230 235 240
Gly Phe Ser Leu Glu Pro Pro Arg Ala Thr Gln Val Asp Pro Cys Asn
245 250 255
Leu Gln Glu Leu Phe Gln Glu Met Ser Ala Asn Val Phe Arg Ile Asn
260 265 270
Ser Ser Val Thr Ser Leu Glu Arg Ser Leu Gln Ser Leu Gly Thr Pro
275 280 285
Ser Asp Thr Gln Glu Leu Arg Asp Ser Leu His Thr Ala Gln Gln Glu
290 295 300
Thr Asn Lys Thr Ile Ala Ala Ser Ala Ser Ser Val Lys Gln Met Ala
305 310 315 320
Glu Leu Leu Arg Ser Ser Cys Pro Gln Glu Arg Leu Gln Gln Glu Arg
325 330 335
Pro Gln Leu Asp Arg Leu Lys Thr Gln Leu Ser Asp Ala Ile Gln Cys
340 345 350
Tyr Gly Val Val Gln Lys Lys Ile Ala Glu Lys Ser Arg Ala Leu Leu
355 360 365
Pro Met Ala Gln Arg Gly Ser Lys Gln Ser Pro Gln Ala Pro Phe Ala
370 375 380
Glu Leu Ala Asp Asp Glu Lys Val Phe Asn Gly Ser Asp Asn Met Trp
385 390 395 400
Gln Gly Gln Glu Gln Ala Leu Leu Pro Asp Ile Thr Glu Glu Asp Leu
405 410 415
Glu Ala Ile Arg Leu Arg Glu Glu Ala Ile Leu Gln Met Glu Ser Asn
420 425 430
Leu Leu Asp Val Asn Gln Ile Ile Lys Asp Leu Ala Ser Met Val Ser
435 440 445
Glu Gln Gly Glu Ala Val Asp Ser Ile Glu Ala Ser Leu Glu Ala Ala
450 455 460
Ser Ser His Ala Glu Ala Ala Arg Gln Leu Leu Ala Gly Ala Ser Arg
465 470 475 480
His Gln Leu Gln Arg His Lys Ile Lys Cys Cys Phe Leu Ser Ala Gly
485 490 495
Val Thr Ala Leu Leu Val Ile Ile Ile Ile Ile Ala Thr Ser Val Arg
500 505 510
Lys
<210> 206
<211> 211
<212> PRT
<213> 人类
<400> 206
Met Asp Asn Leu Ser Ser Glu Glu Ile Gln Gln Arg Ala His Gln Ile
1 5 10 15
Thr Asp Glu Ser Leu Glu Ser Thr Arg Arg Ile Leu Gly Leu Ala Ile
20 25 30
Glu Ser Gln Asp Ala Gly Ile Lys Thr Ile Thr Met Leu Asp Glu Gln
35 40 45
Lys Glu Gln Leu Asn Arg Ile Glu Glu Gly Leu Asp Gln Ile Asn Lys
50 55 60
Asp Met Arg Glu Thr Glu Lys Thr Leu Thr Glu Leu Asn Lys Cys Cys
65 70 75 80
Gly Leu Cys Val Cys Pro Cys Asn Arg Thr Lys Asn Phe Glu Ser Gly
85 90 95
Lys Ala Tyr Lys Thr Thr Trp Gly Asp Gly Gly Glu Asn Ser Pro Cys
100 105 110
Asn Val Val Ser Lys Gln Pro Gly Pro Val Thr Asn Gly Gln Leu Gln
115 120 125
Gln Pro Thr Thr Gly Ala Ala Ser Gly Gly Tyr Ile Lys Arg Ile Thr
130 135 140
Asn Asp Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly
145 150 155 160
Ser Ile Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu
165 170 175
Ile Asp Ala Gln Asn Pro Gln Ile Lys Arg Ile Thr Asp Lys Ala Asp
180 185 190
Thr Asn Arg Asp Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu
195 200 205
Ile Asp Ser
210
<210> 207
<211> 590
<212> PRT
<213> 人类
<400> 207
Met Ser Gly Asp Tyr Glu Asp Asp Leu Cys Arg Arg Ala Leu Ile Leu
1 5 10 15
Val Ser Asp Leu Cys Ala Arg Val Arg Asp Ala Asp Thr Asn Asp Arg
20 25 30
Cys Gln Glu Phe Asn Asp Arg Ile Arg Gly Tyr Pro Arg Gly Pro Asp
35 40 45
Ala Asp Ile Ser Val Ser Leu Leu Ser Val Ile Val Thr Phe Cys Gly
50 55 60
Ile Val Leu Leu Gly Val Ser Leu Phe Val Ser Trp Lys Leu Cys Trp
65 70 75 80
Val Pro Trp Arg Asp Lys Gly Gly Ser Ala Val Gly Gly Gly Pro Leu
85 90 95
Arg Lys Asp Leu Gly Pro Gly Val Gly Leu Ala Gly Leu Val Gly Gly
100 105 110
Gly Gly His His Leu Ala Ala Gly Leu Gly Gly His Pro Leu Leu Gly
115 120 125
Gly Pro His His His Ala His Ala Ala His His Pro Pro Phe Ala Glu
130 135 140
Leu Leu Glu Pro Gly Ser Leu Gly Gly Ser Asp Thr Pro Glu Pro Ser
145 150 155 160
Tyr Leu Asp Met Asp Ser Tyr Pro Glu Ala Ala Ala Ala Ala Val Ala
165 170 175
Ala Gly Val Lys Pro Ser Gln Thr Ser Pro Glu Leu Pro Ser Glu Gly
180 185 190
Gly Ala Gly Ser Gly Leu Leu Leu Leu Pro Pro Ser Gly Gly Gly Leu
195 200 205
Pro Ser Ala Gln Ser His Gln Gln Val Thr Ser Leu Ala Pro Thr Thr
210 215 220
Arg Tyr Pro Ala Leu Pro Arg Pro Leu Thr Gln Gln Thr Leu Thr Ser
225 230 235 240
Gln Pro Asp Pro Ser Ser Glu Glu Arg Pro Pro Ala Leu Pro Leu Pro
245 250 255
Leu Pro Gly Gly Glu Glu Lys Ala Lys Leu Ile Gly Gln Ile Lys Pro
260 265 270
Glu Leu Tyr Gln Gly Thr Gly Pro Gly Gly Arg Arg Ser Gly Gly Gly
275 280 285
Pro Gly Ser Gly Glu Ala Gly Thr Gly Ala Pro Cys Gly Arg Ile Ser
290 295 300
Phe Ala Leu Arg Tyr Leu Tyr Gly Ser Asp Gln Leu Val Val Arg Ile
305 310 315 320
Leu Gln Ala Leu Asp Leu Pro Ala Lys Asp Ser Asn Gly Phe Ser Asp
325 330 335
Pro Tyr Val Lys Ile Tyr Leu Leu Pro Asp Arg Lys Lys Lys Phe Gln
340 345 350
Thr Lys Val His Arg Lys Thr Leu Asn Pro Val Phe Asn Glu Thr Phe
355 360 365
Gln Phe Ser Val Pro Leu Ala Glu Leu Ala Gln Arg Lys Leu His Phe
370 375 380
Ser Val Tyr Asp Phe Asp Arg Phe Ser Arg His Asp Leu Ile Gly Gln
385 390 395 400
Val Val Leu Asp Asn Leu Leu Glu Leu Ala Glu Gln Pro Pro Asp Arg
405 410 415
Pro Leu Trp Arg Asp Ile Val Glu Gly Gly Ser Glu Lys Ala Asp Leu
420 425 430
Gly Glu Leu Asn Phe Ser Leu Cys Tyr Leu Pro Thr Ala Gly Arg Leu
435 440 445
Thr Val Thr Ile Ile Lys Ala Ser Asn Leu Lys Ala Met Asp Leu Thr
450 455 460
Gly Phe Ser Asp Pro Tyr Val Lys Ala Ser Leu Ile Ser Glu Gly Arg
465 470 475 480
Arg Leu Lys Lys Arg Lys Thr Ser Ile Lys Lys Asn Thr Leu Asn Pro
485 490 495
Thr Tyr Asn Glu Ala Leu Val Phe Asp Val Ala Pro Glu Ser Val Glu
500 505 510
Asn Val Gly Leu Ser Ile Ala Val Val Asp Tyr Asp Cys Ile Gly His
515 520 525
Asn Glu Val Ile Gly Val Cys Arg Val Gly Pro Asp Ala Ala Asp Pro
530 535 540
His Gly Arg Glu His Trp Ala Glu Met Leu Ala Asn Pro Arg Lys Pro
545 550 555 560
Val Glu His Trp His Gln Leu Val Glu Glu Lys Thr Val Thr Ser Phe
565 570 575
Thr Lys Gly Ser Lys Gly Leu Ser Glu Lys Glu Asn Ser Glu
580 585 590
<210> 208
<211> 232
<212> PRT
<213> 人类
<400> 208
Met Ala Ser Ser Ala Ala Ser Ser Glu His Phe Glu Lys Leu His Glu
1 5 10 15
Ile Phe Arg Gly Leu His Glu Asp Leu Gln Gly Val Pro Glu Arg Leu
20 25 30
Leu Gly Thr Ala Gly Thr Glu Glu Lys Lys Lys Leu Ile Arg Asp Phe
35 40 45
Asp Glu Lys Gln Gln Glu Ala Asn Glu Thr Leu Ala Glu Met Glu Glu
50 55 60
Glu Leu Arg Tyr Ala Pro Leu Ser Phe Arg Asn Pro Met Met Ser Lys
65 70 75 80
Leu Arg Asn Tyr Arg Lys Asp Leu Ala Lys Leu His Arg Glu Val Arg
85 90 95
Ser Thr Pro Leu Thr Ala Thr Pro Gly Gly Arg Gly Asp Met Lys Tyr
100 105 110
Gly Ile Tyr Ala Val Glu Asn Glu His Met Asn Arg Leu Gln Ser Gln
115 120 125
Arg Ala Met Leu Leu Gln Gly Thr Glu Ser Leu Asn Arg Ala Thr Gln
130 135 140
Ser Ile Glu Arg Ser His Arg Ile Ala Thr Glu Thr Asp Gln Ile Gly
145 150 155 160
Ser Glu Ile Ile Glu Glu Leu Gly Glu Gln Arg Asp Gln Leu Glu Arg
165 170 175
Thr Lys Ser Arg Leu Val Asn Thr Ser Glu Asn Leu Ser Lys Ser Arg
180 185 190
Lys Ile Leu Arg Ser Met Ser Arg Lys Val Thr Thr Asn Lys Leu Leu
195 200 205
Leu Ser Ile Ile Ile Leu Leu Glu Leu Ala Ile Leu Gly Gly Leu Val
210 215 220
Tyr Tyr Lys Phe Phe Arg Ser His
225 230
<210> 209
<211> 236
<212> PRT
<213> 人类
<400> 209
Met Ala Pro Asp Pro Trp Phe Ser Thr Tyr Asp Ser Thr Cys Gln Ile
1 5 10 15
Ala Gln Glu Ile Ala Glu Lys Ile Gln Gln Arg Asn Gln Tyr Glu Arg
20 25 30
Lys Gly Glu Lys Ala Pro Lys Leu Thr Val Thr Ile Arg Ala Leu Leu
35 40 45
Gln Asn Leu Lys Glu Lys Ile Ala Leu Leu Lys Asp Leu Leu Leu Arg
50 55 60
Ala Val Ser Thr His Gln Ile Thr Gln Leu Glu Gly Asp Arg Arg Gln
65 70 75 80
Asn Leu Leu Asp Asp Leu Val Thr Arg Glu Arg Leu Leu Leu Ala Ser
85 90 95
Phe Lys Asn Glu Gly Ala Glu Pro Asp Leu Ile Arg Ser Ser Leu Met
100 105 110
Ser Glu Glu Ala Lys Arg Gly Ala Pro Asn Pro Trp Leu Phe Glu Glu
115 120 125
Pro Glu Glu Thr Arg Gly Leu Gly Phe Asp Glu Ile Arg Gln Gln Gln
130 135 140
Gln Lys Ile Ile Gln Glu Gln Asp Ala Gly Leu Asp Ala Leu Ser Ser
145 150 155 160
Ile Ile Ser Arg Gln Lys Gln Met Gly Gln Glu Ile Gly Asn Glu Leu
165 170 175
Asp Glu Gln Asn Glu Ile Ile Asp Asp Leu Ala Asn Leu Val Glu Asn
180 185 190
Thr Asp Glu Lys Leu Arg Asn Glu Thr Arg Arg Val Asn Met Val Asp
195 200 205
Arg Lys Ser Ala Ser Cys Gly Met Ile Met Val Ile Leu Leu Leu Leu
210 215 220
Val Ala Ile Val Val Val Ala Val Trp Pro Thr Asn
225 230 235
<210> 210
<211> 288
<212> PRT
<213> 褐家鼠
<400> 210
Met Lys Asp Arg Thr Gln Glu Leu Arg Ser Ala Lys Asp Ser Asp Asp
1 5 10 15
Glu Glu Glu Val Val His Val Asp Arg Asp His Phe Met Asp Glu Phe
20 25 30
Phe Glu Gln Val Glu Glu Ile Arg Gly Cys Ile Glu Lys Leu Ser Glu
35 40 45
Asp Val Glu Gln Val Lys Lys Gln His Ser Ala Ile Leu Ala Ala Pro
50 55 60
Asn Pro Asp Glu Lys Thr Lys Gln Glu Leu Glu Asp Leu Thr Ala Asp
65 70 75 80
Ile Lys Lys Thr Ala Asn Lys Val Arg Ser Lys Leu Lys Ala Ile Glu
85 90 95
Gln Ser Ile Glu Gln Glu Glu Gly Leu Asn Arg Ser Ser Ala Asp Leu
100 105 110
Arg Ile Arg Lys Thr Gln His Ser Thr Leu Ser Arg Lys Phe Val Glu
115 120 125
Val Met Thr Glu Tyr Asn Ala Thr Gln Ser Lys Tyr Arg Asp Arg Cys
130 135 140
Lys Asp Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Arg Thr Thr Thr
145 150 155 160
Asn Glu Glu Leu Glu Asp Met Leu Glu Ser Gly Lys Leu Ala Ile Phe
165 170 175
Thr Asp Asp Ile Lys Met Asp Ser Gln Met Thr Lys Gln Ala Leu Asn
180 185 190
Glu Ile Glu Thr Arg His Asn Glu Ile Ile Lys Leu Glu Thr Ser Ile
195 200 205
Arg Glu Leu His Asp Met Phe Val Asp Met Ala Met Leu Val Glu Ser
210 215 220
Gln Gly Glu Met Ile Asp Arg Ile Glu Tyr Asn Val Glu His Ser Val
225 230 235 240
Asp Tyr Val Glu Arg Ala Val Ser Asp Thr Lys Lys Ala Val Lys Tyr
245 250 255
Gln Ser Lys Ala Arg Arg Lys Lys Ile Met Ile Ile Ile Cys Cys Val
260 265 270
Val Leu Gly Val Val Leu Ala Ser Ser Ile Gly Gly Thr Leu Gly Leu
275 280 285
<210> 211
<211> 259
<212> PRT
<213> 人类
<400> 211
Met Ala Ala Ser Arg Leu Glu Leu Asn Leu Val Arg Leu Leu Ser Arg
1 5 10 15
Cys Glu Ala Met Ala Ala Glu Lys Arg Asp Pro Asp Glu Trp Arg Leu
20 25 30
Glu Lys Tyr Val Gly Ala Leu Glu Asp Met Leu Gln Ala Leu Lys Val
35 40 45
His Ala Ser Lys Pro Ala Ser Glu Val Ile Asn Glu Tyr Ser Trp Lys
50 55 60
Val Asp Phe Leu Lys Gly Met Leu Gln Ala Glu Lys Leu Thr Ser Ser
65 70 75 80
Ser Glu Lys Ala Leu Ala Asn Gln Phe Leu Ala Pro Gly Arg Val Pro
85 90 95
Thr Thr Ala Arg Glu Arg Val Pro Ala Thr Lys Thr Val His Leu Gln
100 105 110
Ser Arg Ala Arg Tyr Thr Ser Glu Met Arg Ser Glu Leu Leu Gly Thr
115 120 125
Asp Ser Ala Glu Pro Glu Met Asp Val Arg Lys Arg Thr Gly Val Ala
130 135 140
Gly Ser Gln Pro Val Ser Glu Lys Gln Ser Ala Ala Glu Leu Asp Leu
145 150 155 160
Val Leu Gln Arg His Gln Asn Leu Gln Glu Lys Leu Ala Glu Glu Met
165 170 175
Leu Gly Leu Ala Arg Ser Leu Lys Thr Asn Thr Leu Ala Ala Gln Ser
180 185 190
Val Ile Lys Lys Asp Asn Gln Thr Leu Ser His Ser Leu Lys Met Ala
195 200 205
Asp Gln Asn Leu Glu Lys Leu Lys Thr Glu Ser Glu Arg Leu Glu Gln
210 215 220
His Thr Gln Lys Ser Val Asn Trp Leu Leu Trp Ala Met Leu Ile Ile
225 230 235 240
Val Cys Phe Ile Phe Ile Ser Met Ile Leu Phe Ile Arg Ile Met Pro
245 250 255
Lys Leu Lys
<210> 212
<211> 288
<212> PRT
<213> 人类
<400> 212
Met Lys Asp Arg Thr Gln Glu Leu Arg Ser Ala Lys Asp Ser Asp Asp
1 5 10 15
Glu Glu Glu Val Val His Val Asp Arg Asp His Phe Met Asp Glu Phe
20 25 30
Phe Glu Gln Val Glu Glu Ile Arg Gly Cys Ile Glu Lys Leu Ser Glu
35 40 45
Asp Val Glu Gln Val Lys Lys Gln His Ser Ala Ile Leu Ala Ala Pro
50 55 60
Asn Pro Asp Glu Lys Thr Lys Gln Glu Leu Glu Asp Leu Thr Ala Asp
65 70 75 80
Ile Lys Lys Thr Ala Asn Lys Val Arg Ser Lys Leu Lys Ala Ile Glu
85 90 95
Gln Ser Ile Glu Gln Glu Glu Gly Leu Asn Arg Ser Ser Ala Asp Leu
100 105 110
Arg Ile Arg Lys Thr Gln His Ser Thr Leu Ser Arg Lys Phe Val Glu
115 120 125
Val Met Thr Glu Tyr Asn Ala Thr Gln Ser Lys Tyr Arg Asp Arg Cys
130 135 140
Lys Asp Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Arg Thr Thr Thr
145 150 155 160
Asn Glu Glu Leu Glu Asp Met Leu Glu Ser Gly Lys Leu Ala Ile Phe
165 170 175
Thr Asp Asp Ile Lys Met Asp Ser Gln Met Thr Lys Gln Ala Leu Asn
180 185 190
Glu Ile Glu Thr Arg His Asn Glu Ile Ile Lys Leu Glu Thr Ser Ile
195 200 205
Arg Glu Leu His Asp Met Phe Val Asp Met Ala Met Leu Val Glu Ser
210 215 220
Gln Gly Glu Met Ile Asp Arg Ile Glu Tyr Asn Val Glu His Ser Val
225 230 235 240
Asp Tyr Val Glu Arg Ala Val Ser Asp Thr Lys Lys Ala Val Lys Tyr
245 250 255
Gln Ser Lys Ala Arg Arg Lys Lys Ile Met Ile Ile Ile Cys Cys Val
260 265 270
Val Leu Gly Val Val Leu Ala Ser Ser Ile Gly Gly Thr Leu Gly Leu
275 280 285
<210> 213
<211> 203
<212> PRT
<213> 人类
<400> 213
Met Ser Ser Asp Phe Glu Gly Tyr Glu Gln Asp Phe Ala Val Leu Thr
1 5 10 15
Ala Glu Ile Thr Ser Lys Ile Ala Arg Val Pro Arg Leu Pro Pro Asp
20 25 30
Glu Lys Lys Gln Met Val Ala Asn Val Glu Lys Gln Leu Glu Glu Ala
35 40 45
Lys Glu Leu Leu Glu Gln Met Asp Leu Glu Val Arg Glu Ile Pro Pro
50 55 60
Gln Ser Arg Gly Met Tyr Ser Asn Arg Met Arg Ser Tyr Lys Gln Glu
65 70 75 80
Met Gly Lys Leu Glu Thr Asp Phe Lys Arg Ser Arg Ile Ala Tyr Ser
85 90 95
Asp Glu Val Arg Asn Glu Leu Leu Gly Asp Asp Gly Asn Ser Ser Glu
100 105 110
Asn Gln Arg Ala His Leu Leu Asp Asn Thr Glu Arg Leu Glu Arg Ser
115 120 125
Ser Arg Arg Leu Glu Ala Gly Tyr Gln Ile Ala Val Glu Thr Glu Gln
130 135 140
Ile Gly Gln Glu Met Leu Glu Asn Leu Ser His Asp Arg Glu Lys Ile
145 150 155 160
Gln Arg Ala Arg Glu Arg Leu Arg Glu Thr Asp Ala Asn Leu Gly Lys
165 170 175
Ser Ser Arg Ile Leu Thr Gly Met Leu Arg Arg Gly Cys Ser Val Lys
180 185 190
Lys Gln Cys Asn Leu Ser Leu Ala Pro Lys Ala
195 200
<210> 214
<211> 302
<212> PRT
<213> 人类
<400> 214
Met Ser Glu Asp Glu Glu Lys Val Lys Leu Arg Arg Leu Glu Pro Ala
1 5 10 15
Ile Gln Lys Phe Ile Lys Ile Val Ile Pro Thr Asp Leu Glu Arg Leu
20 25 30
Arg Lys His Gln Ile Asn Ile Glu Lys Tyr Gln Arg Cys Gly Ile Trp
35 40 45
Asp Lys Leu His Glu Glu His Ile Asn Ala Gly Arg Thr Val Gln Gln
50 55 60
Leu Arg Ser Asn Ile Arg Glu Ile Glu Lys Leu Cys Leu Lys Val Arg
65 70 75 80
Lys Asp Asp Leu Val Leu Leu Lys Arg Met Ile Asp Pro Val Lys Glu
85 90 95
Glu Ala Ser Ala Ala Thr Ala Glu Phe Leu Gln Leu His Leu Glu Ser
100 105 110
Val Glu Glu Leu Lys Lys Gln Phe Asn Asp Glu Glu Thr Leu Leu Gln
115 120 125
Pro Pro Leu Thr Arg Ser Met Thr Val Gly Gly Ala Phe His Thr Thr
130 135 140
Glu Ala Glu Ala Ser Ser Gln Ser Leu Thr Gln Ile Tyr Ala Leu Pro
145 150 155 160
Glu Ile Pro Gln Asp Gln Asn Ala Ala Glu Ser Trp Glu Thr Leu Glu
165 170 175
Ala Asp Leu Ile Glu Leu Ser Gln Leu Val Thr Asp Phe Ser Leu Leu
180 185 190
Val Asn Ser Gln Gln Glu Lys Ile Asp Ser Ile Ala Asp His Val Asn
195 200 205
Ser Ala Ala Val Asn Val Glu Glu Gly Thr Lys Asn Leu Gly Lys Ala
210 215 220
Ala Lys Tyr Lys Leu Ala Ala Leu Pro Val Ala Gly Ala Leu Ile Gly
225 230 235 240
Gly Met Val Gly Gly Pro Ile Gly Leu Leu Ala Gly Phe Lys Val Ala
245 250 255
Gly Ile Ala Ala Ala Leu Gly Gly Gly Val Leu Gly Phe Thr Gly Gly
260 265 270
Lys Leu Ile Gln Arg Lys Lys Gln Lys Met Met Glu Lys Leu Thr Ser
275 280 285
Ser Cys Pro Asp Leu Pro Ser Gln Thr Asp Lys Lys Cys Ser
290 295 300
<210> 215
<211> 287
<212> PRT
<213> 人类
<400> 215
Met Arg Asp Arg Leu Pro Asp Leu Thr Ala Cys Arg Lys Asn Asp Asp
1 5 10 15
Gly Asp Thr Val Val Val Val Glu Lys Asp His Phe Met Asp Asp Phe
20 25 30
Phe His Gln Val Glu Glu Ile Arg Asn Ser Ile Asp Lys Ile Thr Gln
35 40 45
Tyr Val Glu Glu Val Lys Lys Asn His Ser Ile Ile Leu Ser Ala Pro
50 55 60
Asn Pro Glu Gly Lys Ile Lys Glu Glu Leu Glu Asp Leu Asn Lys Glu
65 70 75 80
Ile Lys Lys Thr Ala Asn Lys Ile Arg Ala Lys Leu Lys Ala Ile Glu
85 90 95
Gln Ser Phe Asp Gln Asp Glu Ser Gly Asn Arg Thr Ser Val Asp Leu
100 105 110
Arg Ile Arg Arg Thr Gln His Ser Val Leu Ser Arg Lys Phe Val Glu
115 120 125
Ala Met Ala Glu Tyr Asn Glu Ala Gln Thr Leu Phe Arg Glu Arg Ser
130 135 140
Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Arg Thr Thr Thr
145 150 155 160
Asp Asp Glu Leu Glu Glu Met Leu Glu Ser Gly Lys Pro Ser Ile Phe
165 170 175
Thr Ser Asp Ile Ile Ser Asp Ser Gln Ile Thr Arg Gln Ala Leu Asn
180 185 190
Glu Ile Glu Ser Arg His Lys Asp Ile Met Lys Leu Glu Thr Ser Ile
195 200 205
Arg Glu Leu His Glu Met Phe Met Asp Met Ala Met Phe Val Glu Thr
210 215 220
Gln Gly Glu Met Ile Asn Asn Ile Glu Arg Asn Val Met Asn Ala Thr
225 230 235 240
Asp Tyr Val Glu His Ala Lys Glu Glu Thr Lys Lys Ala Ile Lys Tyr
245 250 255
Gln Ser Lys Ala Arg Arg Lys Leu Met Phe Ile Ile Ile Cys Val Ile
260 265 270
Val Leu Leu Val Ile Leu Gly Ile Ile Leu Ala Thr Thr Leu Ser
275 280 285
<210> 216
<211> 297
<212> PRT
<213> 人类
<400> 216
Met Arg Asp Arg Thr His Glu Leu Arg Gln Gly Asp Asp Ser Ser Asp
1 5 10 15
Glu Glu Asp Lys Glu Arg Val Ala Leu Val Val His Pro Gly Thr Ala
20 25 30
Arg Leu Gly Ser Pro Asp Glu Glu Phe Phe His Lys Val Arg Thr Ile
35 40 45
Arg Gln Thr Ile Val Lys Leu Gly Asn Lys Val Gln Glu Leu Glu Lys
50 55 60
Gln Gln Val Thr Ile Leu Ala Thr Pro Leu Pro Glu Glu Ser Met Lys
65 70 75 80
Gln Glu Leu Gln Asn Leu Arg Asp Glu Ile Lys Gln Leu Gly Arg Glu
85 90 95
Ile Arg Leu Gln Leu Lys Ala Ile Glu Pro Gln Lys Glu Glu Ala Asp
100 105 110
Glu Asn Tyr Asn Ser Val Asn Thr Arg Met Arg Lys Thr Gln His Gly
115 120 125
Val Leu Ser Gln Gln Phe Val Glu Leu Ile Asn Lys Cys Asn Ser Met
130 135 140
Gln Ser Glu Tyr Arg Glu Lys Asn Val Glu Arg Ile Arg Arg Gln Leu
145 150 155 160
Lys Ile Thr Asn Ala Gly Met Val Ser Asp Glu Glu Leu Glu Gln Met
165 170 175
Leu Asp Ser Gly Gln Ser Glu Val Phe Val Ser Asn Ile Leu Lys Asp
180 185 190
Thr Gln Val Thr Arg Gln Ala Leu Asn Glu Ile Ser Ala Arg His Ser
195 200 205
Glu Ile Gln Gln Leu Glu Arg Ser Ile Arg Glu Leu His Asp Ile Phe
210 215 220
Thr Phe Leu Ala Thr Glu Val Glu Met Gln Gly Glu Met Ile Asn Arg
225 230 235 240
Ile Glu Lys Asn Ile Leu Ser Ser Ala Asp Tyr Val Glu Arg Gly Gln
245 250 255
Glu His Val Lys Thr Ala Leu Glu Asn Gln Lys Lys Ala Arg Lys Lys
260 265 270
Lys Val Leu Ile Ala Ile Cys Val Ser Ile Thr Val Val Leu Leu Ala
275 280 285
Val Ile Ile Gly Val Thr Val Val Gly
290 295
<210> 217
<211> 134
<212> PRT
<213> 人类
<400> 217
Met Glu Phe Val Met Lys Gln Ala Leu Gly Gly Ala Thr Lys Asp Met
1 5 10 15
Gly Lys Met Leu Gly Gly Asp Glu Glu Lys Asp Pro Asp Ala Ala Lys
20 25 30
Lys Glu Glu Glu Arg Gln Glu Ala Leu Arg Gln Ala Glu Glu Glu Arg
35 40 45
Lys Ala Lys Tyr Ala Lys Met Glu Ala Glu Arg Glu Ala Val Arg Gln
50 55 60
Gly Ile Arg Asp Lys Tyr Gly Ile Lys Lys Lys Glu Glu Arg Glu Ala
65 70 75 80
Glu Ala Gln Ala Ala Met Glu Ala Asn Ser Glu Gly Ser Leu Thr Arg
85 90 95
Pro Lys Lys Ala Ile Pro Pro Gly Cys Gly Asp Glu Val Glu Glu Glu
100 105 110
Asp Glu Ser Ile Leu Asp Thr Val Ile Lys Tyr Leu Pro Gly Pro Leu
115 120 125
Gln Asp Met Leu Lys Lys
130
<210> 218
<211> 289
<212> PRT
<213> 人类
<400> 218
Met Lys Asp Arg Leu Glu Gln Leu Lys Ala Lys Gln Leu Thr Gln Asp
1 5 10 15
Asp Asp Thr Asp Ala Val Glu Ile Ala Ile Asp Asn Thr Ala Phe Met
20 25 30
Asp Glu Phe Phe Ser Glu Ile Glu Glu Thr Arg Leu Asn Ile Asp Lys
35 40 45
Ile Ser Glu His Val Glu Glu Ala Lys Lys Leu Tyr Ser Ile Ile Leu
50 55 60
Ser Ala Pro Ile Pro Glu Pro Lys Thr Lys Asp Asp Leu Glu Gln Leu
65 70 75 80
Thr Thr Glu Ile Lys Lys Arg Ala Asn Asn Val Arg Asn Lys Leu Lys
85 90 95
Ser Met Glu Lys His Ile Glu Glu Asp Glu Val Arg Ser Ser Ala Asp
100 105 110
Leu Arg Ile Arg Lys Ser Gln His Ser Val Leu Ser Arg Lys Phe Val
115 120 125
Glu Val Met Thr Lys Tyr Asn Glu Ala Gln Val Asp Phe Arg Glu Arg
130 135 140
Ser Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Lys Lys Thr
145 150 155 160
Thr Asp Glu Glu Leu Glu Glu Met Leu Glu Ser Gly Asn Pro Ala Ile
165 170 175
Phe Thr Ser Gly Ile Ile Asp Ser Gln Ile Ser Lys Gln Ala Leu Ser
180 185 190
Glu Ile Glu Gly Arg His Lys Asp Ile Val Arg Leu Glu Ser Ser Ile
195 200 205
Lys Glu Leu His Asp Met Phe Met Asp Ile Ala Met Leu Val Glu Asn
210 215 220
Gln Gly Glu Met Leu Asp Asn Ile Glu Leu Asn Val Met His Thr Val
225 230 235 240
Asp His Val Glu Lys Ala Arg Asp Glu Thr Lys Lys Ala Val Lys Tyr
245 250 255
Gln Ser Gln Ala Arg Lys Lys Leu Ile Ile Ile Ile Val Leu Val Val
260 265 270
Val Leu Leu Gly Ile Leu Ala Leu Ile Ile Gly Leu Ser Val Gly Leu
275 280 285
Asn
<210> 219
<211> 276
<212> PRT
<213> 人类
<400> 219
Met Ser Tyr Gly Pro Leu Asp Met Tyr Arg Asn Pro Gly Pro Ser Gly
1 5 10 15
Pro Gln Leu Arg Asp Phe Ser Ser Ile Ile Gln Thr Cys Ser Gly Asn
20 25 30
Ile Gln Arg Ile Ser Gln Ala Thr Ala Gln Ile Lys Asn Leu Met Ser
35 40 45
Gln Leu Gly Thr Lys Gln Asp Ser Ser Lys Leu Gln Glu Asn Leu Gln
50 55 60
Gln Leu Gln His Ser Thr Asn Gln Leu Ala Lys Glu Thr Asn Glu Leu
65 70 75 80
Leu Lys Glu Leu Gly Ser Leu Pro Leu Pro Leu Ser Thr Ser Glu Gln
85 90 95
Arg Gln Gln Arg Leu Gln Lys Glu Arg Leu Met Asn Asp Phe Ser Ala
100 105 110
Ala Leu Asn Asn Phe Gln Ala Val Gln Arg Arg Val Ser Glu Lys Glu
115 120 125
Lys Glu Ser Ile Ala Arg Ala Arg Ala Gly Ser Arg Leu Ser Ala Glu
130 135 140
Glu Arg Gln Arg Glu Glu Gln Leu Val Ser Phe Asp Ser His Glu Glu
145 150 155 160
Trp Asn Gln Met Gln Ser Gln Glu Asp Glu Val Ala Ile Thr Glu Gln
165 170 175
Asp Leu Glu Leu Ile Lys Glu Arg Glu Thr Ala Ile Arg Gln Leu Glu
180 185 190
Ala Asp Ile Leu Asp Val Asn Gln Ile Phe Lys Asp Leu Ala Met Met
195 200 205
Ile His Asp Gln Gly Asp Leu Ile Asp Ser Ile Glu Ala Asn Val Glu
210 215 220
Ser Ser Glu Val His Val Glu Arg Ala Thr Glu Gln Leu Gln Arg Ala
225 230 235 240
Ala Tyr Tyr Gln Lys Lys Ser Arg Lys Lys Met Cys Ile Leu Val Leu
245 250 255
Val Leu Ser Val Ile Ile Leu Ile Leu Gly Leu Ile Ile Trp Leu Val
260 265 270
Tyr Lys Thr Lys
275
<210> 220
<211> 250
<212> PRT
<213> 人类
<400> 220
Met Ala Ala Gly Thr Ser Ser Tyr Trp Glu Asp Leu Arg Lys Gln Ala
1 5 10 15
Arg Gln Leu Glu Asn Glu Leu Asp Leu Lys Leu Val Ser Phe Ser Lys
20 25 30
Leu Cys Thr Ser Tyr Ser His Ser Ser Thr Arg Asp Gly Arg Arg Asp
35 40 45
Arg Tyr Ser Ser Asp Thr Thr Pro Leu Leu Asn Gly Ser Ser Gln Asp
50 55 60
Arg Met Phe Glu Thr Met Ala Ile Glu Ile Glu Gln Leu Leu Ala Arg
65 70 75 80
Leu Thr Gly Val Asn Asp Lys Met Ala Glu Tyr Thr Asn Ser Ala Gly
85 90 95
Val Pro Ser Leu Asn Ala Ala Leu Met His Thr Leu Gln Arg His Arg
100 105 110
Asp Ile Leu Gln Asp Tyr Thr His Glu Phe His Lys Thr Lys Ala Asn
115 120 125
Phe Met Ala Ile Arg Glu Arg Glu Asn Leu Met Gly Ser Val Arg Lys
130 135 140
Asp Ile Glu Ser Tyr Lys Ser Gly Ser Gly Val Asn Asn Arg Arg Thr
145 150 155 160
Glu Leu Phe Leu Lys Glu His Asp His Leu Arg Asn Ser Asp Arg Leu
165 170 175
Ile Glu Glu Thr Ile Ser Ile Ala Met Ala Thr Lys Glu Asn Met Thr
180 185 190
Ser Gln Arg Gly Met Leu Lys Ser Ile His Ser Lys Met Asn Thr Leu
195 200 205
Ala Asn Arg Phe Pro Ala Val Asn Ser Leu Ile Gln Arg Ile Asn Leu
210 215 220
Arg Lys Arg Arg Asp Ser Leu Ile Leu Gly Gly Val Ile Gly Ile Cys
225 230 235 240
Thr Ile Leu Leu Leu Leu Tyr Ala Phe His
245 250
<210> 221
<211> 287
<212> PRT
<213> 人类
<400> 221
Met Lys Asp Arg Leu Ala Glu Leu Leu Asp Leu Ser Lys Gln Tyr Asp
1 5 10 15
Gln Gln Phe Pro Asp Gly Asp Asp Glu Phe Asp Ser Pro His Glu Asp
20 25 30
Ile Val Phe Glu Thr Asp His Ile Leu Glu Ser Leu Tyr Arg Asp Ile
35 40 45
Arg Asp Ile Gln Asp Glu Asn Gln Leu Leu Val Ala Asp Val Lys Arg
50 55 60
Leu Gly Lys Gln Asn Ala Arg Phe Leu Thr Ser Met Arg Arg Leu Ser
65 70 75 80
Ser Ile Lys Arg Asp Thr Asn Ser Ile Ala Lys Ala Ile Lys Ala Arg
85 90 95
Gly Glu Val Ile His Cys Lys Leu Arg Ala Met Lys Glu Leu Ser Glu
100 105 110
Ala Ala Glu Ala Gln His Gly Pro His Ser Ala Val Ala Arg Ile Ser
115 120 125
Arg Ala Gln Tyr Asn Ala Leu Thr Leu Thr Phe Gln Arg Ala Met His
130 135 140
Asp Tyr Asn Gln Ala Glu Met Lys Gln Arg Asp Asn Cys Lys Ile Arg
145 150 155 160
Ile Gln Arg Gln Leu Glu Ile Met Gly Lys Glu Val Ser Gly Asp Gln
165 170 175
Ile Glu Asp Met Phe Glu Gln Gly Lys Trp Asp Val Phe Ser Glu Asn
180 185 190
Leu Leu Ala Asp Val Lys Gly Ala Arg Ala Ala Leu Asn Glu Ile Glu
195 200 205
Ser Arg His Arg Glu Leu Leu Arg Leu Glu Ser Arg Ile Arg Asp Val
210 215 220
His Glu Leu Phe Leu Gln Met Ala Val Leu Val Glu Lys Gln Ala Asp
225 230 235 240
Thr Leu Asn Val Ile Glu Leu Asn Val Gln Lys Thr Val Asp Tyr Thr
245 250 255
Gly Gln Ala Lys Ala Gln Val Arg Lys Ala Val Gln Tyr Glu Glu Lys
260 265 270
Asn Pro Cys Arg Thr Leu Cys Cys Phe Cys Cys Pro Cys Leu Lys
275 280 285
<210> 222
<211> 294
<212> PRT
<213> 人类
<400> 222
Met Lys Asp Arg Leu Gln Glu Leu Lys Gln Arg Thr Lys Glu Ile Glu
1 5 10 15
Leu Ser Arg Asp Ser His Val Ser Thr Thr Glu Thr Glu Glu Gln Gly
20 25 30
Val Phe Leu Gln Gln Ala Val Ile Tyr Glu Arg Glu Pro Val Ala Glu
35 40 45
Arg His Leu His Glu Ile Gln Lys Leu Gln Glu Ser Ile Asn Asn Leu
50 55 60
Ala Asp Asn Val Gln Lys Phe Gly Gln Gln Gln Lys Ser Leu Val Ala
65 70 75 80
Ser Met Arg Arg Phe Ser Leu Leu Lys Arg Glu Ser Thr Ile Thr Lys
85 90 95
Glu Ile Lys Ile Gln Ala Glu Tyr Ile Asn Arg Ser Leu Asn Asp Leu
100 105 110
Val Lys Glu Val Lys Lys Ser Glu Val Glu Asn Gly Pro Ser Ser Val
115 120 125
Val Thr Arg Ile Leu Lys Ser Gln His Ala Ala Met Phe Arg His Phe
130 135 140
Gln Gln Ile Met Phe Ile Tyr Asn Asp Thr Ile Ala Ala Lys Gln Glu
145 150 155 160
Lys Cys Lys Thr Phe Ile Leu Arg Gln Leu Glu Val Ala Gly Lys Glu
165 170 175
Met Ser Glu Glu Asp Val Asn Asp Met Leu His Gln Gly Lys Trp Glu
180 185 190
Val Phe Asn Glu Ser Leu Leu Thr Glu Ile Asn Ile Thr Lys Ala Gln
195 200 205
Leu Ser Glu Ile Glu Gln Arg His Lys Glu Leu Val Asn Leu Glu Asn
210 215 220
Gln Ile Lys Asp Leu Arg Asp Leu Phe Ile Gln Ile Ser Leu Leu Val
225 230 235 240
Glu Glu Gln Gly Glu Ser Ile Asn Asn Ile Glu Met Thr Val Asn Ser
245 250 255
Thr Lys Glu Tyr Val Asn Asn Thr Lys Glu Lys Phe Gly Leu Ala Val
260 265 270
Lys Tyr Lys Lys Arg Asn Pro Cys Arg Val Leu Cys Cys Trp Cys Cys
275 280 285
Pro Cys Cys Ser Ser Lys
290
<210> 223
<211> 211
<212> PRT
<213> 人类
<400> 223
Met Asp Asn Leu Ser Ser Glu Glu Ile Gln Gln Arg Ala His Gln Ile
1 5 10 15
Thr Asp Glu Ser Leu Glu Ser Thr Arg Arg Ile Leu Gly Leu Ala Ile
20 25 30
Glu Ser Gln Asp Ala Gly Ile Lys Thr Ile Thr Met Leu Asp Glu Gln
35 40 45
Lys Glu Gln Leu Asn Arg Ile Glu Glu Gly Leu Asp Gln Ile Asn Lys
50 55 60
Asp Met Arg Glu Thr Glu Lys Thr Leu Thr Glu Leu Asn Lys Cys Cys
65 70 75 80
Gly Leu Cys Val Cys Pro Cys Asn Arg Thr Lys Asn Phe Glu Ser Gly
85 90 95
Lys Ala Tyr Lys Thr Thr Trp Gly Asp Gly Gly Glu Asn Ser Pro Cys
100 105 110
Asn Val Val Ser Lys Gln Pro Gly Pro Val Thr Asn Gly Gln Leu Gln
115 120 125
Gln Pro Thr Thr Gly Ala Ala Ser Gly Gly Tyr Ile Lys Arg Ile Thr
130 135 140
Asn Asp Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly
145 150 155 160
Ser Ile Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu
165 170 175
Ile Asp Ala Gln Asn Pro Gln Ile Lys Arg Ile Thr Asp Lys Ala Asp
180 185 190
Thr Asn Arg Asp Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu
195 200 205
Ile Asp Ser
210
<210> 224
<211> 258
<212> PRT
<213> 人类
<400> 224
Met Ser Ala Tyr Pro Lys Ser Tyr Asn Pro Phe Asp Asp Asp Gly Glu
1 5 10 15
Asp Glu Gly Ala Arg Pro Ala Pro Trp Arg Asp Ala Arg Asp Leu Pro
20 25 30
Asp Gly Pro Asp Ala Pro Ala Asp Arg Gln Gln Tyr Leu Arg Gln Glu
35 40 45
Val Leu Arg Arg Ala Glu Ala Thr Ala Ala Ser Thr Ser Arg Ser Leu
50 55 60
Ala Leu Met Tyr Glu Ser Glu Lys Val Gly Val Ala Ser Ser Glu Glu
65 70 75 80
Leu Ala Arg Gln Arg Gly Val Leu Glu Arg Thr Glu Lys Met Val Asp
85 90 95
Lys Met Asp Gln Asp Leu Lys Ile Ser Gln Lys His Ile Asn Ser Ile
100 105 110
Lys Ser Val Phe Gly Gly Leu Val Asn Tyr Phe Lys Ser Lys Pro Val
115 120 125
Glu Thr Pro Pro Glu Gln Asn Gly Thr Leu Thr Ser Gln Pro Asn Asn
130 135 140
Arg Leu Lys Glu Ala Ile Ser Thr Ser Lys Glu Gln Glu Ala Lys Tyr
145 150 155 160
Gln Ala Ser His Pro Asn Leu Arg Lys Leu Asp Asp Thr Asp Pro Val
165 170 175
Pro Arg Gly Ala Gly Ser Ala Met Ser Thr Asp Ala Tyr Pro Lys Asn
180 185 190
Pro His Leu Arg Ala Tyr His Gln Lys Ile Asp Ser Asn Leu Asp Glu
195 200 205
Leu Ser Met Gly Leu Gly Arg Leu Lys Asp Ile Ala Leu Gly Met Gln
210 215 220
Thr Glu Ile Glu Glu Gln Asp Asp Ile Leu Asp Arg Leu Thr Thr Lys
225 230 235 240
Val Asp Lys Leu Asp Val Asn Ile Lys Ser Thr Glu Arg Lys Val Arg
245 250 255
Gln Leu
<210> 225
<211> 236
<212> PRT
<213> 人类
<400> 225
Met Ala Pro Asp Pro Trp Phe Ser Thr Tyr Asp Ser Thr Cys Gln Ile
1 5 10 15
Ala Gln Glu Ile Ala Glu Lys Ile Gln Gln Arg Asn Gln Tyr Glu Arg
20 25 30
Lys Gly Glu Lys Ala Pro Lys Leu Thr Val Thr Ile Arg Ala Leu Leu
35 40 45
Gln Asn Leu Lys Glu Lys Ile Ala Leu Leu Lys Asp Leu Leu Leu Arg
50 55 60
Ala Val Ser Thr His Gln Ile Thr Gln Leu Glu Gly Asp Arg Arg Gln
65 70 75 80
Asn Leu Leu Asp Asp Leu Val Thr Arg Glu Arg Leu Leu Leu Ala Ser
85 90 95
Phe Lys Asn Glu Gly Ala Glu Pro Asp Leu Ile Arg Ser Ser Leu Met
100 105 110
Ser Glu Glu Ala Lys Arg Gly Ala Pro Asn Pro Trp Leu Phe Glu Glu
115 120 125
Pro Glu Glu Thr Arg Gly Leu Gly Phe Asp Glu Ile Arg Gln Gln Gln
130 135 140
Gln Lys Ile Ile Gln Glu Gln Asp Ala Gly Leu Asp Ala Leu Ser Ser
145 150 155 160
Ile Ile Ser Arg Gln Lys Gln Met Gly Gln Glu Ile Gly Asn Glu Leu
165 170 175
Asp Glu Gln Asn Glu Ile Ile Asp Asp Leu Ala Asn Leu Val Glu Asn
180 185 190
Thr Asp Glu Lys Leu Arg Asn Glu Thr Arg Arg Val Asn Met Val Asp
195 200 205
Arg Lys Ser Ala Ser Cys Gly Met Ile Met Val Ile Leu Leu Leu Leu
210 215 220
Val Ala Ile Val Val Val Ala Val Trp Pro Thr Asn
225 230 235
<210> 226
<211> 261
<212> PRT
<213> 人类
<400> 226
Met Ser Tyr Thr Pro Gly Val Gly Gly Asp Pro Ala Gln Leu Ala Gln
1 5 10 15
Arg Ile Ser Ser Asn Ile Gln Lys Ile Thr Gln Cys Ser Val Glu Ile
20 25 30
Gln Arg Thr Leu Asn Gln Leu Gly Thr Pro Gln Asp Ser Pro Glu Leu
35 40 45
Arg Gln Gln Leu Gln Gln Lys Gln Gln Tyr Thr Asn Gln Leu Ala Lys
50 55 60
Glu Thr Asp Lys Tyr Ile Lys Glu Phe Gly Ser Leu Pro Thr Thr Pro
65 70 75 80
Ser Glu Gln Arg Gln Arg Lys Ile Gln Lys Asp Arg Leu Val Ala Glu
85 90 95
Phe Thr Thr Ser Leu Thr Asn Phe Gln Lys Val Gln Arg Gln Ala Ala
100 105 110
Glu Arg Glu Lys Glu Phe Val Ala Arg Val Arg Ala Ser Ser Arg Val
115 120 125
Ser Gly Ser Phe Pro Glu Asp Ser Ser Lys Glu Arg Asn Leu Val Ser
130 135 140
Trp Glu Ser Gln Thr Gln Pro Gln Val Gln Val Gln Asp Glu Glu Ile
145 150 155 160
Thr Glu Asp Asp Leu Arg Leu Ile His Glu Arg Glu Ser Ser Ile Arg
165 170 175
Gln Leu Glu Ala Asp Ile Met Asp Ile Asn Glu Ile Phe Lys Asp Leu
180 185 190
Gly Met Met Ile His Glu Gln Gly Asp Val Ile Asp Ser Ile Glu Ala
195 200 205
Asn Val Glu Asn Ala Glu Val His Val Gln Gln Ala Asn Gln Gln Leu
210 215 220
Ser Arg Ala Ala Asp Tyr Gln Arg Lys Ser Arg Lys Thr Leu Cys Ile
225 230 235 240
Ile Ile Leu Ile Leu Val Ile Gly Val Ala Ile Ile Ser Leu Ile Ile
245 250 255
Trp Gly Leu Asn His
260
<210> 227
<211> 206
<212> PRT
<213> 人类
<400> 227
Met Ala Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg
1 5 10 15
Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met
20 25 30
Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val
35 40 45
Met Leu Asp Glu Gln Gly Glu Gln Leu Asp Arg Val Glu Glu Gly Met
50 55 60
Asn His Ile Asn Gln Asp Met Lys Glu Ala Glu Lys Asn Leu Lys Asp
65 70 75 80
Leu Gly Lys Cys Cys Gly Leu Phe Ile Cys Pro Cys Asn Lys Leu Lys
85 90 95
Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val
100 105 110
Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala
115 120 125
Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn
130 135 140
Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu
145 150 155 160
Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg
165 170 175
Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile
180 185 190
Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly
195 200 205
<210> 228
<211> 513
<212> PRT
<213> 人类
<400> 228
Met Ser Tyr Gly Ser Ile Ala Arg Gly Gly Gly Leu Gly Ser Arg Gly
1 5 10 15
Pro Phe Gly Gly Pro Ser Arg Gln Gly Cys Gln Pro Leu Glu Cys Ala
20 25 30
Arg Cys Trp Thr Glu Tyr Gly Ile Arg His Phe Pro Cys Pro Ser Pro
35 40 45
Glu Ser Lys Leu Gln Asn Arg Cys Val Gly Lys Asp Gly Glu Gly Asp
50 55 60
Leu Gly Pro Ala Gly Thr Pro Ile Val Pro Arg Ala Arg Lys Arg Gly
65 70 75 80
Pro Gly Val Ala Pro Glu Gly Ser Arg Met Pro Glu Pro Thr Ser Ser
85 90 95
Pro Thr Ile Gly Pro Arg Lys Asp Ser Ala Ala Gly Pro His Gly Arg
100 105 110
Met Ala Gly Pro Ser Thr Thr Arg Ala Lys Lys Arg Lys Pro Asn Phe
115 120 125
Cys Pro Gln Glu Thr Glu Val Leu Val Ser Lys Val Ser Lys His His
130 135 140
Gln Leu Leu Phe Gly Thr Gly Leu Leu Lys Ala Glu Pro Thr Arg Arg
145 150 155 160
Tyr Arg Val Trp Ser Arg Ile Leu Gln Ala Val Asn Ala Leu Gly Tyr
165 170 175
Cys Arg Arg Asp Val Val Asp Leu Lys His Lys Trp Arg Asp Leu Arg
180 185 190
Ala Val Val Arg Arg Lys Leu Gly Asp Leu Arg Lys Ala Ala His Gly
195 200 205
Pro Ser Pro Gly Ser Gly Lys Pro Gln Ala Leu Ala Leu Thr Pro Val
210 215 220
Glu Gln Val Val Ala Lys Thr Phe Ser Cys Gln Ala Leu Pro Ser Glu
225 230 235 240
Gly Phe Ser Leu Glu Pro Pro Arg Ala Thr Gln Val Asp Pro Cys Asn
245 250 255
Leu Gln Glu Leu Phe Gln Glu Met Ser Ala Asn Val Phe Arg Ile Asn
260 265 270
Ser Ser Val Thr Ser Leu Glu Arg Ser Leu Gln Ser Leu Gly Thr Pro
275 280 285
Ser Asp Thr Gln Glu Leu Arg Asp Ser Leu His Thr Ala Gln Gln Glu
290 295 300
Thr Asn Lys Thr Ile Ala Ala Ser Ala Ser Ser Val Lys Gln Met Ala
305 310 315 320
Glu Leu Leu Arg Ser Ser Cys Pro Gln Glu Arg Leu Gln Gln Glu Arg
325 330 335
Pro Gln Leu Asp Arg Leu Lys Thr Gln Leu Ser Asp Ala Ile Gln Cys
340 345 350
Tyr Gly Val Val Gln Lys Lys Ile Ala Glu Lys Ser Arg Ala Leu Leu
355 360 365
Pro Met Ala Gln Arg Gly Ser Lys Gln Ser Pro Gln Ala Pro Phe Ala
370 375 380
Glu Leu Ala Asp Asp Glu Lys Val Phe Asn Gly Ser Asp Asn Met Trp
385 390 395 400
Gln Gly Gln Glu Gln Ala Leu Leu Pro Asp Ile Thr Glu Glu Asp Leu
405 410 415
Glu Ala Ile Arg Leu Arg Glu Glu Ala Ile Leu Gln Met Glu Ser Asn
420 425 430
Leu Leu Asp Val Asn Gln Ile Ile Lys Asp Leu Ala Ser Met Val Ser
435 440 445
Glu Gln Gly Glu Ala Val Asp Ser Ile Glu Ala Ser Leu Glu Ala Ala
450 455 460
Ser Ser His Ala Glu Ala Ala Arg Gln Leu Leu Ala Gly Ala Ser Arg
465 470 475 480
His Gln Leu Gln Arg His Lys Ile Lys Cys Cys Phe Leu Ser Ala Gly
485 490 495
Val Thr Ala Leu Leu Val Ile Ile Ile Ile Ile Ala Thr Ser Val Arg
500 505 510
Lys
<210> 229
<211> 288
<212> PRT
<213> 人类
<400> 229
Met Lys Asp Arg Thr Gln Glu Leu Arg Thr Ala Lys Asp Ser Asp Asp
1 5 10 15
Asp Asp Asp Val Ala Val Thr Val Asp Arg Asp Arg Phe Met Asp Glu
20 25 30
Phe Phe Glu Gln Val Glu Glu Ile Arg Gly Phe Ile Asp Lys Ile Ala
35 40 45
Glu Asn Val Glu Glu Val Lys Arg Lys His Ser Ala Ile Leu Ala Ser
50 55 60
Pro Asn Pro Asp Glu Lys Thr Lys Glu Glu Leu Glu Glu Leu Met Ser
65 70 75 80
Asp Ile Lys Lys Thr Ala Asn Lys Val Arg Ser Lys Leu Lys Ser Ile
85 90 95
Glu Gln Ser Ile Glu Gln Glu Glu Gly Leu Asn Arg Ser Ser Ala Asp
100 105 110
Leu Arg Ile Arg Lys Thr Gln His Ser Thr Leu Ser Arg Lys Phe Val
115 120 125
Glu Val Met Ser Glu Tyr Asn Ala Thr Gln Ser Asp Tyr Arg Glu Arg
130 135 140
Cys Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Arg Thr Thr
145 150 155 160
Thr Ser Glu Glu Leu Glu Asp Met Leu Glu Ser Gly Asn Pro Ala Ile
165 170 175
Phe Ala Ser Gly Ile Ile Met Asp Ser Ser Ile Ser Lys Gln Ala Leu
180 185 190
Ser Glu Ile Glu Thr Arg His Ser Glu Ile Ile Lys Leu Glu Asn Ser
195 200 205
Ile Arg Glu Leu His Asp Met Phe Met Asp Met Ala Met Leu Val Glu
210 215 220
Ser Gln Gly Glu Met Ile Asp Arg Ile Glu Tyr Asn Val Glu His Ala
225 230 235 240
Val Asp Tyr Val Glu Arg Ala Val Ser Asp Thr Lys Lys Ala Val Lys
245 250 255
Tyr Gln Ser Lys Ala Arg Arg Lys Lys Ile Met Ile Ile Ile Cys Cys
260 265 270
Val Ile Leu Gly Ile Val Ile Ala Ser Thr Val Gly Gly Ile Phe Ala
275 280 285
<210> 230
<211> 355
<212> PRT
<213> 人类
<400> 230
Met Ile Pro Arg Lys Arg Tyr Gly Ser Lys Asn Thr Asp Gln Gly Val
1 5 10 15
Tyr Leu Gly Leu Ser Lys Thr Gln Val Leu Ser Pro Ala Thr Ala Gly
20 25 30
Ser Ser Ser Ser Asp Ile Ala Pro Leu Pro Pro Pro Val Thr Leu Val
35 40 45
Pro Pro Pro Pro Asp Thr Met Ser Cys Arg Asp Arg Thr Gln Glu Phe
50 55 60
Leu Ser Ala Cys Lys Ser Leu Gln Thr Arg Gln Asn Gly Ile Gln Thr
65 70 75 80
Asn Lys Pro Ala Leu Arg Ala Val Arg Gln Arg Ser Glu Phe Thr Leu
85 90 95
Met Ala Lys Arg Ile Gly Lys Asp Leu Ser Asn Thr Phe Ala Lys Leu
100 105 110
Glu Lys Leu Thr Ile Leu Ala Lys Arg Lys Ser Leu Phe Asp Asp Lys
115 120 125
Ala Val Glu Ile Glu Glu Leu Thr Tyr Ile Ile Lys Gln Asp Ile Asn
130 135 140
Ser Leu Asn Lys Gln Ile Ala Gln Leu Gln Asp Phe Val Arg Ala Lys
145 150 155 160
Gly Ser Gln Ser Gly Arg His Leu Gln Thr His Ser Asn Thr Ile Val
165 170 175
Val Ser Leu Gln Ser Lys Leu Ala Ser Met Ser Asn Asp Phe Lys Ser
180 185 190
Val Leu Glu Val Arg Thr Glu Asn Leu Lys Gln Gln Arg Ser Arg Arg
195 200 205
Glu Gln Phe Ser Arg Ala Pro Val Ser Ala Leu Pro Leu Ala Pro Asn
210 215 220
His Leu Gly Gly Gly Ala Val Val Leu Gly Ala Glu Ser His Ala Ser
225 230 235 240
Lys Asp Val Ala Ile Asp Met Met Asp Ser Arg Thr Ser Gln Gln Leu
245 250 255
Gln Leu Ile Asp Glu Gln Asp Ser Tyr Ile Gln Ser Arg Ala Asp Thr
260 265 270
Met Gln Asn Ile Glu Ser Thr Ile Val Glu Leu Gly Ser Ile Phe Gln
275 280 285
Gln Leu Ala His Met Val Lys Glu Gln Glu Glu Thr Ile Gln Arg Ile
290 295 300
Asp Glu Asn Val Leu Gly Ala Gln Leu Asp Val Glu Ala Ala His Ser
305 310 315 320
Glu Ile Leu Lys Tyr Phe Gln Ser Val Thr Ser Asn Arg Trp Leu Met
325 330 335
Val Lys Ile Phe Leu Ile Leu Ile Val Phe Phe Ile Ile Phe Val Val
340 345 350
Phe Leu Ala
355
<210> 231
<211> 258
<212> PRT
<213> 人类
<400> 231
Met Ser Ala Tyr Pro Lys Ser Tyr Asn Pro Phe Asp Asp Asp Gly Glu
1 5 10 15
Asp Glu Gly Ala Arg Pro Ala Pro Trp Arg Asp Ala Arg Asp Leu Pro
20 25 30
Asp Gly Pro Asp Ala Pro Ala Asp Arg Gln Gln Tyr Leu Arg Gln Glu
35 40 45
Val Leu Arg Arg Ala Glu Ala Thr Ala Ala Ser Thr Ser Arg Ser Leu
50 55 60
Ala Leu Met Tyr Glu Ser Glu Lys Val Gly Val Ala Ser Ser Glu Glu
65 70 75 80
Leu Ala Arg Gln Arg Gly Val Leu Glu Arg Thr Glu Lys Met Val Asp
85 90 95
Lys Met Asp Gln Asp Leu Lys Ile Ser Gln Lys His Ile Asn Ser Ile
100 105 110
Lys Ser Val Phe Gly Gly Leu Val Asn Tyr Phe Lys Ser Lys Pro Val
115 120 125
Glu Thr Pro Pro Glu Gln Asn Gly Thr Leu Thr Ser Gln Pro Asn Asn
130 135 140
Arg Leu Lys Glu Ala Ile Ser Thr Ser Lys Glu Gln Glu Ala Lys Tyr
145 150 155 160
Gln Ala Ser His Pro Asn Leu Arg Lys Leu Asp Asp Thr Asp Pro Val
165 170 175
Pro Arg Gly Ala Gly Ser Ala Met Ser Thr Asp Ala Tyr Pro Lys Asn
180 185 190
Pro His Leu Arg Ala Tyr His Gln Lys Ile Asp Ser Asn Leu Asp Glu
195 200 205
Leu Ser Met Gly Leu Gly Arg Leu Lys Asp Ile Ala Leu Gly Met Gln
210 215 220
Thr Glu Ile Glu Glu Gln Asp Asp Ile Leu Asp Arg Leu Thr Thr Lys
225 230 235 240
Val Asp Lys Leu Asp Val Asn Ile Lys Ser Thr Glu Arg Lys Val Arg
245 250 255
Gln Leu
<210> 232
<211> 200
<212> PRT
<213> 人类
<400> 232
Met Ser Leu Glu Asp Pro Phe Phe Val Val Arg Gly Glu Val Gln Lys
1 5 10 15
Ala Val Asn Thr Ala Arg Gly Leu Tyr Gln Arg Trp Cys Glu Leu Leu
20 25 30
Gln Glu Ser Ala Ala Val Gly Arg Glu Glu Leu Asp Trp Thr Thr Asn
35 40 45
Glu Leu Arg Asn Gly Leu Arg Ser Ile Glu Trp Asp Leu Glu Asp Leu
50 55 60
Glu Glu Thr Ile Gly Ile Val Glu Ala Asn Pro Gly Lys Pro Ala Ala
65 70 75 80
Gln Lys Ser Pro Ser Asp Leu Leu Asp Ala Ser Ala Val Ser Ala Thr
85 90 95
Ser Arg Tyr Ile Glu Glu Gln Gln Ala Thr Gln Gln Leu Ile Met Asp
100 105 110
Glu Gln Asp Gln Gln Leu Glu Met Val Ser Gly Ser Ile Gln Val Leu
115 120 125
Lys His Met Ser Gly Arg Val Gly Glu Glu Leu Asp Glu Gln Gly Ile
130 135 140
Met Leu Asp Ala Phe Ala Gln Glu Met Asp His Thr Gln Ser Arg Met
145 150 155 160
Asp Gly Val Leu Arg Lys Leu Ala Lys Val Ser His Met Thr Ser Asp
165 170 175
Arg Arg Gln Trp Cys Ala Ile Ala Val Leu Val Gly Val Leu Leu Leu
180 185 190
Val Leu Ile Leu Leu Phe Ser Leu
195 200
<210> 233
<211> 294
<212> PRT
<213> 人类
<400> 233
Met Lys Asp Arg Leu Gln Glu Leu Lys Gln Arg Thr Lys Glu Ile Glu
1 5 10 15
Leu Ser Arg Asp Ser His Val Ser Thr Thr Glu Thr Glu Glu Gln Gly
20 25 30
Val Phe Leu Gln Gln Ala Val Ile Tyr Glu Arg Glu Pro Val Ala Glu
35 40 45
Arg His Leu His Glu Ile Gln Lys Leu Gln Glu Ser Ile Asn Asn Leu
50 55 60
Ala Asp Asn Val Gln Lys Phe Gly Gln Gln Gln Lys Ser Leu Val Ala
65 70 75 80
Ser Met Arg Arg Phe Ser Leu Leu Lys Arg Glu Ser Thr Ile Thr Lys
85 90 95
Glu Ile Lys Ile Gln Ala Glu Tyr Ile Asn Arg Ser Leu Asn Asp Leu
100 105 110
Val Lys Glu Val Lys Lys Ser Glu Val Glu Asn Gly Pro Ser Ser Val
115 120 125
Val Thr Arg Ile Leu Lys Ser Gln His Ala Ala Met Phe Arg His Phe
130 135 140
Gln Gln Ile Met Phe Ile Tyr Asn Asp Thr Ile Ala Ala Lys Gln Glu
145 150 155 160
Lys Cys Lys Thr Phe Ile Leu Arg Gln Leu Glu Val Ala Gly Lys Glu
165 170 175
Met Ser Glu Glu Asp Val Asn Asp Met Leu His Gln Gly Lys Trp Glu
180 185 190
Val Phe Asn Glu Ser Leu Leu Thr Glu Ile Asn Ile Thr Lys Ala Gln
195 200 205
Leu Ser Glu Ile Glu Gln Arg His Lys Glu Leu Val Asn Leu Glu Asn
210 215 220
Gln Ile Lys Asp Leu Arg Asp Leu Phe Ile Gln Ile Ser Leu Leu Val
225 230 235 240
Glu Glu Gln Gly Glu Ser Ile Asn Asn Ile Glu Met Thr Val Asn Ser
245 250 255
Thr Lys Glu Tyr Val Asn Asn Thr Lys Glu Lys Phe Gly Leu Ala Val
260 265 270
Lys Tyr Lys Lys Arg Asn Pro Cys Arg Val Leu Cys Cys Trp Cys Cys
275 280 285
Pro Cys Cys Ser Ser Lys
290
<210> 234
<211> 198
<212> PRT
<213> 人类
<400> 234
Met Lys Leu Tyr Ser Leu Ser Val Leu Tyr Lys Gly Glu Ala Lys Val
1 5 10 15
Val Leu Leu Lys Ala Ala Tyr Asp Val Ser Ser Phe Ser Phe Phe Gln
20 25 30
Arg Ser Ser Val Gln Glu Phe Met Thr Phe Thr Ser Gln Leu Ile Val
35 40 45
Glu Arg Ser Ser Lys Gly Thr Arg Ala Ser Val Lys Glu Gln Asp Tyr
50 55 60
Leu Cys His Val Tyr Val Arg Asn Asp Ser Leu Ala Gly Val Val Ile
65 70 75 80
Ala Asp Asn Glu Tyr Pro Ser Arg Val Ala Phe Thr Leu Leu Glu Lys
85 90 95
Val Leu Asp Glu Phe Ser Lys Gln Val Asp Arg Ile Asp Trp Pro Val
100 105 110
Gly Ser Pro Ala Thr Ile His Tyr Pro Ala Leu Asp Gly His Leu Ser
115 120 125
Arg Tyr Gln Asn Pro Arg Glu Ala Asp Leu Met Thr Lys Val Gln Ala
130 135 140
Glu Leu Asp Glu Thr Lys Ile Ile Leu His Asn Thr Met Glu Ser Leu
145 150 155 160
Leu Glu Arg Gly Glu Lys Leu Asp Asp Leu Val Ser Lys Ser Glu Val
165 170 175
Leu Gly Thr Gln Ser Lys Ala Phe Tyr Lys Thr Ala Arg Lys Gln Asn
180 185 190
Ser Cys Cys Ala Ile Met
195
<210> 235
<211> 279
<212> PRT
<213> 人类
<400> 235
Met Gln Leu Thr Gln Asp Asp Asp Thr Asp Ala Val Glu Ile Ala Ile
1 5 10 15
Asp Asn Thr Ala Phe Met Asp Glu Phe Phe Ser Glu Ile Glu Glu Thr
20 25 30
Arg Leu Asn Ile Asp Lys Ile Ser Glu His Val Glu Glu Ala Lys Lys
35 40 45
Leu Tyr Ser Ile Ile Leu Ser Ala Pro Ile Pro Glu Pro Lys Thr Lys
50 55 60
Asp Asp Leu Glu Gln Leu Ser Thr Glu Ile Lys Lys Arg Ala Asn Asn
65 70 75 80
Val Arg Asn Lys Leu Lys Ser Met Glu Lys His Ile Glu Glu Asp Glu
85 90 95
Val Arg Ser Ser Ala Asp Leu Arg Ile Arg Lys Ser Gln His Ser Val
100 105 110
Leu Ser Arg Lys Phe Val Glu Val Met Thr Lys Tyr Asn Glu Ala Gln
115 120 125
Val Asp Phe Arg Glu Arg Ser Lys Gly Arg Ile Gln Arg Gln Leu Glu
130 135 140
Ile Thr Gly Lys Lys Thr Thr Asp Glu Glu Leu Glu Glu Met Leu Glu
145 150 155 160
Ser Gly Asn Pro Ala Ile Phe Thr Ser Gly Ile Ile Asp Ser Gln Ile
165 170 175
Ser Lys Gln Ala Leu Ser Glu Ile Glu Gly Arg His Lys Asp Ile Val
180 185 190
Arg Leu Glu Ser Ser Ile Lys Glu Leu His Asp Met Phe Met Asp Ile
195 200 205
Ala Met Leu Val Glu Asn Gln Gly Glu Met Leu Asp Asn Ile Glu Leu
210 215 220
Asn Val Met His Thr Val Asp His Val Glu Lys Ala Arg Asp Glu Ser
225 230 235 240
Lys Lys Ala Val Lys Tyr Gln Ser Gln Ala Arg Lys Lys Leu Ile Ile
245 250 255
Ile Ile Val Leu Val Val Val Leu Leu Gly Ile Leu Ala Leu Ile Ile
260 265 270
Gly Leu Ser Val Gly Leu Asn
275
<210> 236
<211> 297
<212> PRT
<213> 人类
<400> 236
Met Arg Asp Arg Thr His Glu Leu Arg Gln Gly Asp Asp Ser Ser Asp
1 5 10 15
Glu Glu Asp Lys Glu Arg Val Ala Leu Val Val His Pro Gly Thr Ala
20 25 30
Arg Leu Gly Ser Pro Asp Glu Glu Phe Phe His Lys Val Arg Thr Ile
35 40 45
Arg Gln Thr Ile Val Lys Leu Gly Asn Lys Val Gln Glu Leu Glu Lys
50 55 60
Gln Gln Val Thr Ile Leu Ala Thr Pro Leu Pro Glu Glu Ser Met Lys
65 70 75 80
Gln Glu Leu Gln Asn Leu Arg Asp Glu Ile Lys Gln Leu Gly Arg Glu
85 90 95
Ile Arg Leu Gln Leu Lys Ala Ile Glu Pro Gln Lys Glu Glu Ala Asp
100 105 110
Glu Asn Tyr Asn Ser Val Asn Thr Arg Met Arg Lys Thr Gln His Gly
115 120 125
Val Leu Ser Gln Gln Phe Val Glu Leu Ile Asn Lys Cys Asn Ser Met
130 135 140
Gln Ser Glu Tyr Arg Glu Lys Asn Val Glu Arg Ile Arg Arg Gln Leu
145 150 155 160
Lys Ile Thr Asn Ala Gly Met Val Ser Asp Glu Glu Leu Glu Gln Met
165 170 175
Leu Asp Ser Gly Gln Ser Glu Val Phe Val Ser Asn Ile Leu Lys Asp
180 185 190
Thr Gln Val Thr Arg Gln Ala Leu Asn Glu Ile Ser Ala Arg His Ser
195 200 205
Glu Ile Gln Gln Leu Glu Arg Ser Ile Arg Glu Leu His Asp Ile Phe
210 215 220
Thr Phe Leu Ala Thr Glu Val Glu Met Gln Gly Glu Met Ile Asn Arg
225 230 235 240
Ile Glu Lys Asn Ile Leu Ser Ser Ala Asp Tyr Val Glu Arg Gly Gln
245 250 255
Glu His Val Lys Thr Ala Leu Glu Asn Gln Lys Lys Ala Arg Lys Lys
260 265 270
Lys Val Leu Ile Ala Ile Cys Val Ser Ile Thr Val Val Leu Leu Ala
275 280 285
Val Ile Ile Gly Val Thr Val Val Gly
290 295
<210> 237
<211> 255
<212> PRT
<213> 人类
<400> 237
Met Ser Met Glu Asp Pro Phe Phe Val Val Lys Gly Glu Val Gln Lys
1 5 10 15
Ala Val Asn Thr Ala Gln Gly Leu Phe Gln Arg Trp Thr Glu Leu Leu
20 25 30
Gln Asp Pro Ser Thr Ala Thr Arg Glu Glu Ile Asp Trp Thr Thr Asn
35 40 45
Glu Leu Arg Asn Asn Leu Arg Ser Ile Glu Trp Asp Leu Glu Asp Leu
50 55 60
Asp Glu Thr Ile Ser Ile Val Glu Ala Asn Pro Arg Lys Phe Asn Leu
65 70 75 80
Asp Ala Thr Glu Leu Ser Ile Arg Lys Ala Phe Ile Thr Ser Thr Arg
85 90 95
Gln Val Val Arg Asp Met Lys Asp Gln Met Ser Thr Ser Ser Val Gln
100 105 110
Ala Leu Ala Glu Arg Lys Asn Arg Gln Ala Leu Leu Gly Asp Ser Gly
115 120 125
Ser Gln Asn Trp Ser Thr Gly Thr Thr Asp Lys Tyr Gly Arg Leu Asp
130 135 140
Arg Glu Leu Gln Arg Ala Asn Ser His Phe Ile Glu Glu Gln Gln Ala
145 150 155 160
Gln Gln Gln Leu Ile Val Glu Gln Gln Asp Glu Gln Leu Glu Leu Val
165 170 175
Ser Gly Ser Ile Gly Val Leu Lys Asn Met Ser Gln Arg Ile Gly Gly
180 185 190
Glu Leu Glu Glu Gln Ala Val Met Leu Glu Asp Phe Ser His Glu Leu
195 200 205
Glu Ser Thr Gln Ser Arg Leu Asp Asn Val Met Lys Lys Leu Ala Lys
210 215 220
Val Ser His Met Thr Ser Asp Arg Arg Gln Trp Cys Ala Ile Ala Ile
225 230 235 240
Leu Phe Ala Val Leu Leu Val Val Leu Ile Leu Phe Leu Val Leu
245 250 255
<210> 238
<211> 289
<212> PRT
<213> 人类
<400> 238
Met Lys Asp Arg Leu Glu Gln Leu Lys Ala Lys Gln Leu Thr Gln Asp
1 5 10 15
Asp Asp Thr Asp Ala Val Glu Ile Ala Ile Asp Asn Thr Ala Phe Met
20 25 30
Asp Glu Phe Phe Ser Glu Ile Glu Glu Thr Arg Leu Asn Ile Asp Lys
35 40 45
Ile Ser Glu His Val Glu Glu Ala Lys Lys Leu Tyr Ser Ile Ile Leu
50 55 60
Ser Ala Pro Ile Pro Glu Pro Lys Thr Lys Asp Asp Leu Glu Gln Leu
65 70 75 80
Thr Thr Glu Ile Lys Lys Arg Ala Asn Asn Val Arg Asn Lys Leu Lys
85 90 95
Ser Met Glu Lys His Ile Glu Glu Asp Glu Val Arg Ser Ser Ala Asp
100 105 110
Leu Arg Ile Arg Lys Ser Gln His Ser Val Leu Ser Arg Lys Phe Val
115 120 125
Glu Val Met Thr Lys Tyr Asn Glu Ala Gln Val Asp Phe Arg Glu Arg
130 135 140
Ser Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Lys Lys Thr
145 150 155 160
Thr Asp Glu Glu Leu Glu Glu Met Leu Glu Ser Gly Asn Pro Ala Ile
165 170 175
Phe Thr Ser Gly Ile Ile Asp Ser Gln Ile Ser Lys Gln Ala Leu Ser
180 185 190
Glu Ile Glu Gly Arg His Lys Asp Ile Val Arg Leu Glu Ser Ser Ile
195 200 205
Lys Glu Leu His Asp Met Phe Met Asp Ile Ala Met Leu Val Glu Asn
210 215 220
Gln Gly Glu Met Leu Asp Asn Ile Glu Leu Asn Val Met His Thr Val
225 230 235 240
Asp His Val Glu Lys Ala Arg Asp Glu Thr Lys Lys Ala Val Lys Tyr
245 250 255
Gln Ser Gln Ala Arg Lys Lys Leu Ile Ile Ile Ile Val Leu Val Val
260 265 270
Val Leu Leu Gly Ile Leu Ala Leu Ile Ile Gly Leu Ser Val Gly Leu
275 280 285
Asn
<210> 239
<211> 246
<212> PRT
<213> 人类
<400> 239
Met Ser Leu Glu Asp Pro Phe Phe Val Val Arg Gly Glu Val Gln Lys
1 5 10 15
Ala Val Asn Thr Ala Arg Gly Leu Tyr Gln Arg Trp Cys Glu Leu Leu
20 25 30
Gln Glu Ser Ala Ala Val Gly Arg Glu Glu Leu Asp Trp Thr Thr Asn
35 40 45
Glu Leu Arg Asn Gly Leu Arg Ser Ile Glu Trp Asp Leu Glu Asp Leu
50 55 60
Glu Glu Thr Ile Gly Ile Val Glu Ala Asn Pro Gly Lys Phe Lys Leu
65 70 75 80
Pro Ala Gly Asp Leu Gln Glu Arg Lys Val Phe Val Glu Arg Met Arg
85 90 95
Glu Ala Val Gln Glu Met Lys Asp His Met Val Ser Pro Thr Ala Val
100 105 110
Ala Phe Leu Glu Arg Asn Asn Arg Glu Ile Leu Ala Gly Lys Pro Ala
115 120 125
Ala Gln Lys Ser Pro Ser Asp Leu Leu Asp Ala Ser Ala Val Ser Ala
130 135 140
Thr Ser Arg Tyr Ile Glu Glu Gln Gln Ala Thr Gln Gln Leu Ile Met
145 150 155 160
Asp Glu Gln Asp Gln Gln Leu Glu Met Val Ser Gly Ser Ile Gln Val
165 170 175
Leu Lys His Met Ser Gly Arg Val Gly Glu Glu Leu Asp Glu Gln Gly
180 185 190
Ile Met Leu Asp Ala Phe Ala Gln Glu Met Asp His Thr Gln Ser Arg
195 200 205
Met Asp Gly Val Leu Arg Lys Leu Ala Lys Val Ser His Met Thr Ser
210 215 220
Gly Glu Ser Pro Gln Gly Arg Gly Gln Ser Trp Trp Gly Gln Val Val
225 230 235 240
Gly Gly Thr Leu Ser Pro
245
<210> 240
<211> 260
<212> PRT
<213> 人类
<400> 240
Met Lys Asp Arg Thr Gln Glu Leu Arg Thr Ala Lys Asp Ser Asp Asp
1 5 10 15
Asp Asp Asp Val Ala Val Thr Val Asp Arg Asp Arg Phe Met Asp Glu
20 25 30
Phe Phe Glu Gln Val Glu Glu Ile Arg Gly Phe Ile Asp Lys Ile Ala
35 40 45
Glu Asn Val Glu Glu Val Lys Arg Lys His Ser Ala Ile Leu Ala Ser
50 55 60
Pro Asn Pro Asp Glu Lys Thr Lys Glu Glu Leu Glu Glu Leu Met Ser
65 70 75 80
Asp Ile Lys Lys Thr Ala Asn Lys Val Arg Ser Lys Leu Lys Ser Ile
85 90 95
Glu Gln Ser Ile Glu Gln Glu Glu Gly Leu Asn Arg Ser Ser Ala Asp
100 105 110
Leu Arg Ile Arg Lys Thr Gln His Ser Thr Leu Ser Arg Lys Phe Val
115 120 125
Glu Val Met Ser Glu Tyr Asn Ala Thr Gln Ser Asp Tyr Arg Glu Arg
130 135 140
Cys Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Arg Thr Thr
145 150 155 160
Thr Ser Glu Glu Leu Glu Asp Met Leu Glu Ser Gly Asn Pro Ala Ile
165 170 175
Phe Ala Ser Gly Ile Ile Met Asp Ser Ser Ile Ser Lys Gln Ala Leu
180 185 190
Ser Glu Ile Glu Thr Arg His Ser Glu Ile Ile Lys Leu Glu Asn Ser
195 200 205
Ile Arg Glu Leu His Asp Met Phe Met Asp Met Ala Met Leu Val Glu
210 215 220
Ser Gln Pro Gln Gly Ala Phe Leu Lys Ser Cys Pro Glu Pro Gln Pro
225 230 235 240
Asn Pro Glu Glu Gly Ala Leu Trp Ser Ser Gly Ala Pro Gly Pro Ala
245 250 255
Gly Arg Asp Asp
260
<210> 241
<211> 236
<212> PRT
<213> 人类
<400> 241
Met Ala Pro Asp Pro Trp Phe Ser Thr Tyr Asp Ser Thr Cys Gln Ile
1 5 10 15
Ala Gln Glu Ile Ala Glu Lys Ile Gln Gln Arg Asn Gln Tyr Glu Arg
20 25 30
Lys Gly Glu Lys Ala Pro Lys Leu Thr Val Thr Ile Arg Ala Leu Leu
35 40 45
Gln Asn Leu Lys Glu Lys Ile Ala Leu Leu Lys Asp Leu Leu Leu Arg
50 55 60
Ala Val Ser Thr His Gln Ile Thr Gln Leu Glu Gly Asp Arg Arg Gln
65 70 75 80
Asn Leu Leu Asp Asp Leu Val Thr Arg Glu Arg Leu Leu Leu Ala Ser
85 90 95
Phe Lys Asn Glu Gly Ala Glu Pro Asp Leu Ile Arg Ser Ser Leu Met
100 105 110
Ser Glu Glu Ala Lys Arg Gly Ala Pro Asn Pro Trp Leu Phe Glu Glu
115 120 125
Pro Glu Glu Thr Arg Gly Leu Gly Phe Asp Glu Ile Arg Gln Gln Gln
130 135 140
Gln Lys Ile Ile Gln Glu Gln Asp Ala Gly Leu Asp Ala Leu Ser Ser
145 150 155 160
Ile Ile Ser Arg Gln Lys Gln Met Gly Gln Glu Ile Gly Asn Glu Leu
165 170 175
Asp Glu Gln Asn Glu Ile Ile Asp Asp Leu Ala Asn Leu Val Glu Asn
180 185 190
Thr Asp Glu Lys Leu Arg Asn Glu Thr Arg Arg Val Asn Met Val Asp
195 200 205
Arg Lys Ser Ala Ser Cys Gly Met Ile Met Val Ile Leu Leu Leu Leu
210 215 220
Val Ala Ile Val Val Val Ala Val Trp Pro Thr Asn
225 230 235
<210> 242
<211> 198
<212> PRT
<213> 人类
<400> 242
Met Lys Leu Tyr Ser Leu Ser Val Leu Tyr Lys Gly Glu Ala Lys Val
1 5 10 15
Val Leu Leu Lys Ala Ala Tyr Asp Val Ser Ser Phe Ser Phe Phe Gln
20 25 30
Arg Ser Ser Val Gln Glu Phe Met Thr Phe Thr Ser Gln Leu Ile Val
35 40 45
Glu Arg Ser Ser Lys Gly Thr Arg Ala Ser Val Lys Glu Gln Asp Tyr
50 55 60
Leu Cys His Val Tyr Val Arg Asn Asp Ser Leu Ala Gly Val Val Ile
65 70 75 80
Ala Asp Asn Glu Tyr Pro Ser Arg Val Ala Phe Thr Leu Leu Glu Lys
85 90 95
Val Leu Asp Glu Phe Ser Lys Gln Val Asp Arg Ile Asp Trp Pro Val
100 105 110
Gly Ser Pro Ala Thr Ile His Tyr Pro Ala Leu Asp Gly His Leu Ser
115 120 125
Arg Tyr Gln Asn Pro Arg Glu Ala Asp Pro Met Thr Lys Val Gln Ala
130 135 140
Glu Leu Asp Glu Thr Lys Ile Ile Leu His Asn Thr Met Glu Ser Leu
145 150 155 160
Leu Glu Arg Gly Glu Lys Leu Asp Asp Leu Val Ser Lys Ser Glu Val
165 170 175
Leu Gly Thr Gln Ser Lys Ala Phe Tyr Lys Thr Ala Arg Lys Gln Asn
180 185 190
Ser Cys Cys Ala Ile Met
195
<210> 243
<211> 136
<212> PRT
<213> 人类
<400> 243
Met Ala Gly Ala Gly Ser Ala Ala Val Ser Gly Ala Gly Thr Pro Val
1 5 10 15
Ala Gly Pro Thr Gly Arg Asp Leu Phe Ala Glu Gly Leu Leu Glu Phe
20 25 30
Leu Arg Pro Ala Val Gln Gln Leu Asp Ser His Val His Ala Val Arg
35 40 45
Glu Ser Gln Val Glu Leu Arg Glu Gln Ile Asp Asn Leu Ala Thr Glu
50 55 60
Leu Cys Arg Ile Asn Glu Asp Gln Lys Val Ala Leu Asp Leu Asp Pro
65 70 75 80
Tyr Val Lys Lys Leu Leu Asn Ala Arg Arg Arg Val Val Leu Val Asn
85 90 95
Asn Ile Leu Gln Asn Ala Gln Glu Arg Leu Arg Arg Leu Asn His Ser
100 105 110
Val Ala Lys Glu Thr Ala Arg Arg Arg Ala Met Leu Asp Ser Gly Ile
115 120 125
Tyr Pro Pro Gly Ser Pro Gly Lys
130 135
<210> 244
<211> 211
<212> PRT
<213> 人类
<400> 244
Met Asp Asn Leu Ser Ser Glu Glu Ile Gln Gln Arg Ala His Gln Ile
1 5 10 15
Thr Asp Glu Ser Leu Glu Ser Thr Arg Arg Ile Leu Gly Leu Ala Ile
20 25 30
Glu Ser Gln Asp Ala Gly Ile Lys Thr Ile Thr Met Leu Asp Glu Gln
35 40 45
Lys Glu Gln Leu Asn Arg Ile Glu Glu Gly Leu Asp Gln Ile Asn Lys
50 55 60
Asp Met Arg Glu Thr Glu Lys Thr Leu Thr Glu Leu Asn Lys Cys Cys
65 70 75 80
Gly Leu Cys Val Cys Pro Cys Asn Arg Thr Lys Asn Phe Glu Ser Gly
85 90 95
Lys Ala Tyr Lys Thr Thr Trp Gly Asp Gly Gly Glu Asn Ser Pro Cys
100 105 110
Asn Val Val Ser Lys Gln Pro Gly Pro Val Thr Asn Gly Gln Leu Gln
115 120 125
Gln Pro Thr Thr Gly Ala Ala Ser Gly Gly Tyr Ile Lys Arg Ile Thr
130 135 140
Asn Asp Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly
145 150 155 160
Ser Ile Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu
165 170 175
Ile Asp Ala Gln Asn Pro Gln Ile Lys Arg Ile Thr Asp Lys Ala Asp
180 185 190
Thr Asn Arg Asp Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu
195 200 205
Ile Asp Ser
210
<210> 245
<211> 158
<212> PRT
<213> 人类
<400> 245
Met Asp Asn Leu Ser Ser Glu Glu Ile Gln Gln Arg Ala His Gln Ile
1 5 10 15
Thr Asp Glu Ser Leu Glu Ser Thr Arg Arg Ile Leu Gly Leu Ala Ile
20 25 30
Glu Ser Gln Asp Ala Gly Ile Lys Thr Ile Thr Met Leu Asp Glu Gln
35 40 45
Lys Glu Gln Leu Asn Arg Ile Glu Glu Gly Leu Asp Gln Ile Asn Lys
50 55 60
Asp Met Arg Glu Thr Glu Lys Thr Leu Thr Glu Leu Asn Lys Cys Cys
65 70 75 80
Gly Leu Cys Val Cys Pro Cys Asn Ser Ile Thr Asn Asp Ala Arg Glu
85 90 95
Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly Ser Ile Leu Gly Asn
100 105 110
Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu Ile Asp Ala Gln Asn
115 120 125
Pro Gln Ile Lys Arg Ile Thr Asp Lys Ala Asp Thr Asn Arg Asp Arg
130 135 140
Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu Ile Asp Ser
145 150 155
<210> 246
<211> 100
<212> PRT
<213> 人类
<400> 246
Met Ser Thr Gly Pro Thr Ala Ala Thr Gly Ser Asn Arg Arg Leu Gln
1 5 10 15
Gln Thr Gln Asn Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn
20 25 30
Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp
35 40 45
Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala
50 55 60
Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Cys Lys Met Trp Ala
65 70 75 80
Ile Gly Ile Thr Val Leu Val Ile Phe Ile Ile Ile Ile Ile Val Trp
85 90 95
Val Val Ser Ser
100
<210> 247
<211> 202
<212> PRT
<213> 人类
<400> 247
Met Ala Thr Arg Arg Leu Thr Asp Ala Phe Leu Leu Leu Arg Asn Asn
1 5 10 15
Ser Ile Gln Asn Arg Gln Leu Leu Ala Glu Gln Glu Leu Asp Glu Leu
20 25 30
Ala Asp Asp Arg Met Ala Leu Val Ser Gly Ile Ser Leu Asp Pro Glu
35 40 45
Ala Ala Ile Gly Val Thr Lys Arg Pro Pro Pro Lys Trp Val Asp Gly
50 55 60
Val Asp Glu Ile Gln Tyr Asp Val Gly Arg Ile Lys Gln Lys Met Lys
65 70 75 80
Glu Leu Ala Ser Leu His Asp Lys His Leu Asn Arg Pro Thr Leu Asp
85 90 95
Asp Ser Ser Glu Glu Glu His Ala Ile Glu Ile Thr Thr Gln Glu Ile
100 105 110
Thr Gln Leu Phe His Arg Cys Gln Arg Ala Val Gln Ala Leu Pro Ser
115 120 125
Arg Ala Arg Ala Cys Ser Glu Gln Glu Gly Arg Leu Leu Gly Asn Val
130 135 140
Val Ala Ser Leu Ala Gln Ala Leu Gln Glu Leu Ser Thr Ser Phe Arg
145 150 155 160
His Ala Gln Ser Gly Tyr Leu Lys Arg Met Lys Asn Arg Glu Glu Arg
165 170 175
Ser Gln His Phe Phe Asp Thr Ser Val Pro Leu Met Asp Asp Gly Asp
180 185 190
Asp Asn Thr Leu Tyr His Arg Arg Thr Ser
195 200
<210> 248
<211> 260
<212> PRT
<213> 人类
<400> 248
Met Ala Ile Leu Phe Ala Val Val Ala Arg Gly Thr Thr Ile Leu Ala
1 5 10 15
Lys His Ala Trp Cys Gly Gly Asn Phe Leu Glu Val Thr Glu Gln Ile
20 25 30
Leu Ala Lys Ile Pro Ser Glu Asn Asn Lys Leu Thr Tyr Ser His Gly
35 40 45
Asn Tyr Leu Phe His Tyr Ile Cys Gln Asp Arg Ile Val Tyr Leu Cys
50 55 60
Ile Thr Asp Asp Asp Phe Glu Arg Ser Arg Ala Phe Asn Phe Leu Asn
65 70 75 80
Glu Ile Lys Lys Arg Phe Gln Thr Thr Tyr Gly Ser Arg Ala Gln Thr
85 90 95
Ala Leu Pro Tyr Ala Met Asn Ser Glu Phe Ser Ser Val Leu Ala Ala
100 105 110
Gln Leu Lys His His Ser Glu Asn Lys Gly Leu Asp Lys Val Met Glu
115 120 125
Thr Gln Ala Gln Val Asp Glu Leu Lys Gly Ile Met Val Arg Asn Ile
130 135 140
Val Cys His Leu Gln Asn Tyr Gln Gln Lys Ser Cys Ser Ser His Val
145 150 155 160
Tyr Glu Glu Pro Gln Ala His Tyr Tyr His His His Arg Ile Asn Cys
165 170 175
Val His Leu Tyr His Cys Phe Thr Ser Leu Trp Trp Ile Tyr Met Ala
180 185 190
Lys Leu Cys Glu Glu Ile Gly Lys Lys Lys Leu Pro Leu Thr Lys Asp
195 200 205
Met Arg Glu Gln Gly Val Lys Ser Asn Pro Cys Asp Ser Ser Leu Ser
210 215 220
His Thr Asp Arg Trp Tyr Leu Pro Val Ser Ser Thr Leu Phe Ser Leu
225 230 235 240
Phe Lys Ile Leu Phe His Ala Ser Arg Phe Ile Phe Val Leu Ser Thr
245 250 255
Ser Leu Phe Leu
260
<210> 249
<211> 335
<212> PRT
<213> 人类
<400> 249
Met Ala Val Asp Ile Thr Leu Leu Phe Arg Ala Ser Val Lys Thr Val
1 5 10 15
Lys Thr Arg Asn Lys Ala Leu Gly Val Ala Val Gly Gly Gly Val Asp
20 25 30
Gly Ser Arg Asp Glu Leu Phe Arg Arg Ser Pro Arg Pro Lys Gly Asp
35 40 45
Phe Ser Ser Arg Ala Arg Glu Val Ile Ser His Ile Gly Lys Leu Arg
50 55 60
Asp Phe Leu Leu Glu His Arg Lys Asp Tyr Ile Asn Ala Tyr Ser His
65 70 75 80
Thr Met Ser Glu Tyr Gly Arg Met Thr Asp Thr Glu Arg Asp Gln Ile
85 90 95
Asp Gln Asp Ala Gln Ile Phe Met Arg Thr Cys Ser Glu Ala Ile Gln
100 105 110
Gln Leu Arg Thr Glu Ala His Lys Glu Ile His Ser Gln Gln Val Lys
115 120 125
Glu His Arg Thr Ala Val Leu Asp Phe Ile Glu Asp Tyr Leu Lys Arg
130 135 140
Val Cys Lys Leu Tyr Ser Glu Gln Arg Ala Ile Arg Val Lys Arg Val
145 150 155 160
Val Asp Lys Lys Arg Leu Ser Lys Leu Glu Pro Glu Pro Asn Thr Lys
165 170 175
Thr Arg Glu Ser Thr Ser Ser Glu Lys Val Ser Gln Ser Pro Ser Lys
180 185 190
Asp Ser Glu Glu Asn Pro Ala Thr Glu Glu Arg Pro Glu Lys Ile Leu
195 200 205
Ala Glu Thr Gln Pro Glu Leu Gly Thr Trp Gly Asp Gly Lys Gly Glu
210 215 220
Asp Glu Leu Ser Pro Glu Glu Ile Gln Met Phe Glu Gln Glu Asn Gln
225 230 235 240
Arg Leu Ile Gly Glu Met Asn Ser Leu Phe Asp Glu Val Arg Gln Ile
245 250 255
Glu Gly Arg Val Val Glu Ile Ser Arg Leu Gln Glu Ile Phe Thr Glu
260 265 270
Lys Val Leu Gln Gln Glu Ala Glu Ile Asp Ser Ile His Gln Leu Val
275 280 285
Val Gly Ala Thr Glu Asn Ile Lys Glu Gly Asn Glu Asp Ile Arg Glu
290 295 300
Ala Ile Lys Asn Asn Ala Gly Phe Arg Val Trp Ile Leu Phe Phe Leu
305 310 315 320
Val Met Cys Ser Phe Ser Leu Leu Phe Leu Asp Trp Tyr Asp Ser
325 330 335
<210> 250
<211> 538
<212> PRT
<213> 人类
<400> 250
Met Pro Gly Ser Gly Pro Ser Glu Arg Met Thr Trp Pro Gly Pro Ala
1 5 10 15
Leu Ser Ala Gly Pro Pro Thr Arg Pro Leu Ser Ser Ala Pro Gly Ile
20 25 30
Pro Pro Ile Pro Pro Leu Thr Arg Thr His Ser Leu Met Ala Met Ser
35 40 45
Leu Pro Gly Ser Arg Arg Thr Ser Ala Gly Ser Arg Arg Arg Thr Ser
50 55 60
Pro Pro Val Ser Val Arg Asp Ala Tyr Gly Thr Ser Ser Leu Ser Ser
65 70 75 80
Ser Ser Asn Ser Gly Ser Tyr Lys Gly Ser Asp Ser Ser Pro Thr Pro
85 90 95
Arg Arg Ser Met Lys Tyr Thr Leu Cys Ser Asp Asn His Gly Ile Lys
100 105 110
Pro Pro Thr Pro Glu Gln Tyr Leu Thr Pro Leu Gln Gln Lys Glu Val
115 120 125
Cys Ile Arg His Leu Lys Ala Arg Leu Lys Asp Thr Gln Asp Arg Leu
130 135 140
Gln Asp Arg Asp Thr Glu Ile Asp Asp Leu Lys Thr Gln Leu Ser Arg
145 150 155 160
Met Gln Glu Asp Trp Ile Glu Glu Glu Cys His Arg Val Glu Ala Gln
165 170 175
Leu Ala Leu Lys Glu Ala Arg Lys Glu Ile Lys Gln Leu Lys Gln Val
180 185 190
Ile Asp Thr Val Lys Asn Asn Leu Ile Asp Lys Asp Lys Gly Leu Gln
195 200 205
Lys Tyr Phe Val Asp Ile Asn Ile Gln Asn Lys Lys Leu Glu Thr Leu
210 215 220
Leu His Ser Met Glu Val Ala Gln Asn Gly Met Ala Lys Glu Asp Gly
225 230 235 240
Thr Gly Glu Ser Ala Gly Gly Ser Pro Ala Arg Ser Leu Thr Arg Ser
245 250 255
Ser Thr Tyr Thr Lys Leu Ser Asp Pro Ala Val Cys Gly Asp Arg Gln
260 265 270
Pro Gly Asp Pro Ser Ser Gly Ser Ala Glu Asp Gly Ala Asp Ser Gly
275 280 285
Phe Ala Ala Ala Asp Asp Thr Leu Ser Arg Thr Asp Ala Leu Glu Ala
290 295 300
Ser Ser Leu Leu Ser Ser Gly Val Asp Cys Gly Thr Glu Glu Thr Ser
305 310 315 320
Leu His Ser Ser Phe Gly Leu Gly Pro Arg Phe Pro Ala Ser Asn Thr
325 330 335
Tyr Glu Lys Leu Leu Cys Gly Met Glu Ala Gly Val Gln Ala Ser Cys
340 345 350
Met Gln Glu Arg Ala Ile Gln Thr Asp Phe Val Gln Tyr Gln Pro Asp
355 360 365
Leu Asp Thr Ile Leu Glu Lys Val Thr Gln Ala Gln Val Cys Gly Thr
370 375 380
Asp Pro Glu Ser Gly Asp Arg Cys Pro Glu Leu Asp Ala His Pro Ser
385 390 395 400
Gly Pro Arg Asp Pro Asn Ser Ala Val Val Val Thr Val Gly Asp Glu
405 410 415
Leu Glu Ala Pro Glu Pro Ile Thr Arg Gly Pro Thr Pro Gln Arg Pro
420 425 430
Gly Ala Asn Pro Asn Pro Gly Gln Ser Val Ser Val Val Cys Pro Met
435 440 445
Glu Glu Glu Glu Glu Ala Ala Val Ala Glu Lys Glu Pro Lys Ser Tyr
450 455 460
Trp Ser Arg His Tyr Ile Val Asp Leu Leu Ala Val Val Val Pro Ala
465 470 475 480
Val Pro Thr Val Ala Trp Leu Cys Arg Ser Gln Arg Arg Gln Gly Gln
485 490 495
Pro Ile Tyr Asn Ile Ser Ser Leu Leu Arg Gly Cys Cys Thr Val Ala
500 505 510
Leu His Ser Ile Arg Arg Ile Ser Cys Arg Ser Leu Ser Gln Pro Ser
515 520 525
Pro Ser Pro Ala Gly Gly Gly Ser Gln Leu
530 535
<210> 251
<211> 136
<212> PRT
<213> 人类
<400> 251
Met Ala Gly Ala Gly Ser Ala Ala Val Ser Gly Ala Gly Thr Pro Val
1 5 10 15
Ala Gly Pro Thr Gly Arg Asp Leu Phe Ala Glu Gly Leu Leu Glu Phe
20 25 30
Leu Arg Pro Ala Val Gln Gln Leu Asp Ser His Val His Ala Val Arg
35 40 45
Glu Ser Gln Val Glu Leu Arg Glu Gln Ile Asp Asn Leu Ala Thr Glu
50 55 60
Leu Cys Arg Ile Asn Glu Asp Gln Lys Val Ala Leu Asp Leu Asp Pro
65 70 75 80
Tyr Val Lys Lys Leu Leu Asn Ala Arg Arg Arg Val Val Leu Val Asn
85 90 95
Asn Ile Leu Gln Asn Ala Gln Glu Arg Leu Arg Arg Leu Asn His Ser
100 105 110
Val Ala Lys Glu Thr Ala Arg Arg Arg Ala Met Leu Asp Ser Gly Ile
115 120 125
Tyr Pro Pro Gly Ser Pro Gly Lys
130 135
<210> 252
<211> 592
<212> PRT
<213> 人类
<400> 252
Met Ala Pro Pro Val Ala Glu Arg Gly Leu Lys Ser Val Val Trp Gln
1 5 10 15
Lys Ile Lys Ala Thr Val Phe Asp Asp Cys Lys Lys Glu Gly Glu Trp
20 25 30
Lys Ile Met Leu Leu Asp Glu Phe Thr Thr Lys Leu Leu Ala Ser Cys
35 40 45
Cys Lys Met Thr Asp Leu Leu Glu Glu Gly Ile Thr Val Val Glu Asn
50 55 60
Ile Tyr Lys Asn Arg Glu Pro Val Arg Gln Met Lys Ala Leu Tyr Phe
65 70 75 80
Ile Thr Pro Thr Ser Lys Ser Val Asp Cys Phe Leu His Asp Phe Ala
85 90 95
Ser Lys Ser Glu Asn Lys Tyr Lys Ala Ala Tyr Ile Tyr Phe Thr Asp
100 105 110
Phe Cys Pro Asp Asn Leu Phe Asn Lys Ile Lys Ala Ser Cys Ser Lys
115 120 125
Ser Ile Arg Arg Cys Lys Glu Ile Asn Ile Ser Phe Ile Pro His Glu
130 135 140
Ser Gln Val Tyr Thr Leu Asp Val Pro Asp Ala Phe Tyr Tyr Cys Tyr
145 150 155 160
Ser Pro Asp Pro Gly Asn Ala Lys Gly Lys Asp Ala Ile Met Glu Thr
165 170 175
Met Ala Asp Gln Ile Val Thr Val Cys Ala Thr Leu Asp Glu Asn Pro
180 185 190
Gly Val Arg Tyr Lys Ser Lys Pro Leu Asp Asn Ala Ser Lys Leu Ala
195 200 205
Gln Leu Val Glu Lys Lys Leu Glu Asp Tyr Tyr Lys Ile Asp Glu Lys
210 215 220
Ser Leu Ile Lys Gly Lys Thr His Ser Gln Leu Leu Ile Ile Asp Arg
225 230 235 240
Gly Phe Asp Pro Val Ser Thr Val Leu His Glu Leu Thr Phe Gln Ala
245 250 255
Met Ala Tyr Asp Leu Leu Pro Ile Glu Asn Asp Thr Tyr Lys Tyr Lys
260 265 270
Thr Asp Gly Lys Glu Lys Glu Ala Ile Leu Glu Glu Glu Asp Asp Leu
275 280 285
Trp Val Arg Ile Arg His Arg His Ile Ala Val Val Leu Glu Glu Ile
290 295 300
Pro Lys Leu Met Lys Glu Ile Ser Ser Thr Lys Lys Ala Thr Glu Gly
305 310 315 320
Lys Thr Ser Leu Ser Ala Leu Thr Gln Leu Met Lys Lys Met Pro His
325 330 335
Phe Arg Lys Gln Ile Thr Lys Gln Val Val His Leu Asn Leu Ala Glu
340 345 350
Asp Cys Met Asn Lys Phe Lys Leu Asn Ile Glu Lys Leu Cys Lys Thr
355 360 365
Glu Gln Asp Leu Ala Leu Gly Thr Asp Ala Glu Gly Gln Lys Val Lys
370 375 380
Asp Ser Met Arg Val Leu Leu Pro Val Leu Leu Asn Lys Asn His Asp
385 390 395 400
Asn Cys Asp Lys Ile Arg Ala Ile Leu Leu Tyr Ile Phe Ser Ile Asn
405 410 415
Gly Thr Thr Glu Glu Asn Leu Asp Arg Leu Ile Gln Asn Val Lys Ile
420 425 430
Glu Asn Glu Ser Asp Met Ile Arg Asn Trp Ser Tyr Leu Gly Val Pro
435 440 445
Ile Val Pro Gln Ser Gln Gln Gly Lys Pro Leu Arg Lys Asp Arg Ser
450 455 460
Ala Glu Glu Thr Phe Gln Leu Ser Arg Trp Thr Pro Phe Ile Lys Asp
465 470 475 480
Ile Met Glu Asp Ala Ile Asp Asn Arg Leu Asp Ser Lys Glu Trp Pro
485 490 495
Tyr Cys Ser Gln Cys Pro Ala Val Trp Asn Gly Ser Gly Ala Val Ser
500 505 510
Ala Arg Gln Lys Pro Arg Ala Asn Tyr Leu Glu Asp Arg Lys Asn Gly
515 520 525
Ser Lys Leu Ile Val Phe Val Ile Gly Gly Ile Thr Tyr Ser Glu Val
530 535 540
Arg Cys Ala Tyr Glu Val Ser Gln Ala His Lys Ser Cys Glu Val Ile
545 550 555 560
Ile Gly Ser Thr His Val Leu Thr Pro Lys Lys Leu Leu Asp Asp Ile
565 570 575
Lys Met Leu Asn Lys Pro Lys Asp Lys Val Ser Leu Ile Lys Asp Glu
580 585 590
<210> 253
<211> 250
<212> PRT
<213> 人类
<400> 253
Met Ala Ala Gly Thr Ser Ser Tyr Trp Glu Asp Leu Arg Lys Gln Ala
1 5 10 15
Arg Gln Leu Glu Asn Glu Leu Asp Leu Lys Leu Val Ser Phe Ser Lys
20 25 30
Leu Cys Thr Ser Tyr Ser His Ser Ser Thr Arg Asp Gly Arg Arg Asp
35 40 45
Arg Tyr Ser Ser Asp Thr Thr Pro Leu Leu Asn Gly Ser Ser Gln Asp
50 55 60
Arg Met Phe Glu Thr Met Ala Ile Glu Ile Glu Gln Leu Leu Ala Arg
65 70 75 80
Leu Thr Gly Val Asn Asp Lys Met Ala Glu Tyr Thr Asn Ser Ala Gly
85 90 95
Val Pro Ser Leu Asn Ala Ala Leu Met His Thr Leu Gln Arg His Arg
100 105 110
Asp Ile Leu Gln Asp Tyr Thr His Glu Phe His Lys Thr Lys Ala Asn
115 120 125
Phe Met Ala Ile Arg Glu Arg Glu Asn Leu Met Gly Ser Val Arg Lys
130 135 140
Asp Ile Glu Ser Tyr Lys Ser Gly Ser Gly Val Asn Asn Arg Arg Thr
145 150 155 160
Glu Leu Phe Leu Lys Glu His Asp His Leu Arg Asn Ser Asp Arg Leu
165 170 175
Ile Glu Glu Thr Ile Ser Ile Ala Met Ala Thr Lys Glu Asn Met Thr
180 185 190
Ser Gln Arg Gly Met Leu Lys Ser Ile His Ser Lys Met Asn Thr Leu
195 200 205
Ala Asn Arg Phe Pro Ala Val Asn Ser Leu Ile Gln Arg Ile Asn Leu
210 215 220
Arg Lys Arg Arg Asp Ser Leu Ile Leu Gly Gly Val Ile Gly Ile Cys
225 230 235 240
Thr Ile Leu Leu Leu Leu Tyr Ala Phe His
245 250
<210> 254
<211> 287
<212> PRT
<213> 人类
<400> 254
Met Lys Asp Arg Leu Ala Glu Leu Leu Asp Leu Ser Lys Gln Tyr Asp
1 5 10 15
Gln Gln Phe Pro Asp Gly Asp Asp Glu Phe Asp Ser Pro His Glu Asp
20 25 30
Ile Val Phe Glu Thr Asp His Ile Leu Glu Ser Leu Tyr Arg Asp Ile
35 40 45
Arg Asp Ile Gln Asp Glu Asn Gln Leu Leu Val Ala Asn Val Lys Arg
50 55 60
Leu Gly Lys Gln Asn Ala Arg Phe Leu Thr Ser Met Arg Arg Leu Ser
65 70 75 80
Ser Ile Lys Arg Asp Thr Asn Ser Ile Ala Lys Ala Ile Lys Ala Pro
85 90 95
Pro Glu Val Ile His Cys Asn Val Arg Ala Met Lys Glu Leu Ser Glu
100 105 110
Ala Ala Glu Ala Gln His Gly Pro Ala Leu Gly Ser Gly Gly Ile Ser
115 120 125
Arg Ala Gln Tyr Asn Ala Leu Thr Leu Thr Phe Gln Arg Ala Met His
130 135 140
Asp Tyr Asn Gln Ala Glu Met Lys Gln Arg Asp Asn Cys Lys Ile Arg
145 150 155 160
Ile Gln Arg Gln Leu Glu Ile Met Gly Lys Glu Val Ser Gly Asp Gln
165 170 175
Ile Glu Asp Met Phe Glu Gln Gly Lys Trp Asp Val Phe Ser Glu Asn
180 185 190
Leu Leu Ala Asp Val Lys Gly Val Arg Ala Ala Leu Asn Glu Ile Glu
195 200 205
Ser Arg His Arg Glu Leu Val Arg Leu Glu Ser Ala Ile Arg Asp Val
210 215 220
His Glu Leu Phe Leu Gln Met Ala Val Leu Val Glu Lys Gln Ala Asp
225 230 235 240
Thr Leu Asn Val Ile Glu Leu Asn Val Gln Lys Thr Val Asp Tyr Thr
245 250 255
Gly Gln Ala Lys Ala Gln Val Arg Lys Ala Val Gln Tyr Glu Glu Lys
260 265 270
Asn Pro Cys Arg Thr Leu Cys Cys Phe Cys Cys Pro Cys Leu Lys
275 280 285
<210> 255
<211> 301
<212> PRT
<213> 人类
<400> 255
Met Ser Cys Arg Asp Arg Thr Gln Glu Phe Leu Ser Ala Cys Lys Ser
1 5 10 15
Leu Gln Thr Arg Gln Asn Gly Ile Gln Thr Asn Lys Pro Ala Leu Arg
20 25 30
Ala Val Arg Gln Arg Ser Glu Phe Thr Leu Met Ala Lys Arg Ile Gly
35 40 45
Lys Asp Leu Ser Asn Thr Phe Ala Lys Leu Glu Lys Leu Thr Ile Leu
50 55 60
Ala Lys Arg Lys Ser Leu Phe Asp Asp Lys Ala Val Glu Ile Glu Glu
65 70 75 80
Leu Thr Tyr Ile Ile Lys Gln Asp Ile Asn Ser Leu Asn Lys Gln Ile
85 90 95
Ala Gln Leu Gln Asp Phe Val Arg Ala Lys Gly Ser Gln Ser Gly Arg
100 105 110
His Leu Gln Thr His Ser Asn Thr Ile Val Val Ser Leu Gln Ser Lys
115 120 125
Leu Ala Ser Met Ser Asn Asp Phe Lys Ser Val Leu Glu Val Arg Thr
130 135 140
Glu Asn Leu Lys Gln Gln Arg Ser Arg Arg Glu Gln Phe Ser Arg Ala
145 150 155 160
Pro Val Ser Ala Leu Pro Leu Ala Pro Asn His Leu Gly Gly Gly Ala
165 170 175
Val Val Leu Gly Ala Glu Ser His Ala Ser Lys Asp Val Ala Ile Asp
180 185 190
Met Met Asp Ser Arg Thr Ser Gln Gln Leu Gln Leu Ile Asp Glu Gln
195 200 205
Asp Ser Tyr Ile Gln Ser Arg Ala Asp Thr Met Gln Asn Ile Glu Ser
210 215 220
Thr Ile Val Glu Leu Gly Ser Ile Phe Gln Gln Leu Ala His Met Val
225 230 235 240
Lys Glu Gln Glu Glu Thr Ile Gln Arg Ile Asp Glu Asn Val Leu Gly
245 250 255
Ala Gln Leu Asp Val Glu Ala Ala His Ser Glu Ile Leu Lys Tyr Phe
260 265 270
Gln Ser Val Thr Ser Asn Arg Trp Leu Met Val Lys Ile Phe Leu Ile
275 280 285
Leu Ile Val Phe Phe Ile Ile Phe Val Val Phe Leu Ala
290 295 300
<210> 256
<211> 261
<212> PRT
<213> 人类
<400> 256
Met Ser Tyr Thr Pro Gly Val Gly Gly Asp Pro Thr Gln Leu Ala Gln
1 5 10 15
Arg Ile Ser Ser Asn Ile Gln Lys Ile Thr Gln Cys Ser Val Glu Ile
20 25 30
Gln Arg Thr Leu Asn Gln Leu Gly Thr Pro Gln Asp Ser Pro Glu Leu
35 40 45
Arg Gln Gln Leu Gln Gln Lys Gln Gln Tyr Thr Asn Gln Leu Ala Lys
50 55 60
Glu Thr Asp Lys Tyr Ile Lys Glu Phe Gly Ser Leu Pro Thr Thr Pro
65 70 75 80
Ser Glu Gln Arg Gln Arg Lys Ile Gln Lys Asp Arg Leu Val Ala Glu
85 90 95
Phe Thr Thr Ser Leu Thr Asn Phe Gln Lys Val Gln Arg Gln Ala Ala
100 105 110
Glu Arg Glu Lys Glu Phe Val Ala Arg Val Arg Ala Ser Ser Arg Val
115 120 125
Ser Gly Ser Phe Pro Glu Asp Ser Ser Lys Glu Arg Asn Leu Val Ser
130 135 140
Trp Glu Ser Gln Thr Gln Pro Gln Val Gln Val Gln Asp Glu Glu Ile
145 150 155 160
Thr Glu Asp Asp Leu Arg Leu Ile His Glu Arg Glu Ser Ser Ile Arg
165 170 175
Gln Leu Glu Ala Asp Ile Met Asp Ile Asn Glu Ile Phe Lys Asp Leu
180 185 190
Gly Met Met Ile His Glu Gln Gly Asp Val Ile Asp Ser Ile Glu Ala
195 200 205
Asn Val Glu Asn Ala Glu Val His Val Gln Gln Ala Asn Gln Gln Leu
210 215 220
Ser Arg Ala Ala Asp Tyr Gln Arg Lys Ser Arg Lys Thr Leu Cys Ile
225 230 235 240
Ile Ile Leu Ile Leu Val Ile Gly Val Ala Ile Ile Ser Leu Ile Ile
245 250 255
Trp Gly Leu Asn His
260
<210> 257
<211> 141
<212> PRT
<213> 人类
<400> 257
Met Pro Pro Lys Phe Lys Arg His Leu Asn Asp Asp Asp Val Thr Gly
1 5 10 15
Ser Val Lys Ser Glu Arg Arg Asn Leu Leu Glu Asp Asp Ser Asp Glu
20 25 30
Glu Glu Asp Phe Phe Leu Arg Gly Pro Ser Gly Pro Arg Phe Gly Pro
35 40 45
Arg Asn Asp Lys Ile Lys His Val Gln Asn Gln Val Asp Glu Val Ile
50 55 60
Asp Val Met Pro Glu Asn Ile Thr Lys Val Ile Glu Arg Gly Glu Arg
65 70 75 80
Leu Asp Glu Leu Gln Asp Lys Ser Glu Ser Leu Ser Asp Asn Ala Thr
85 90 95
Ala Phe Ser Asn Arg Ser Lys Gln Leu Arg Arg Gln Met Trp Trp Arg
100 105 110
Gly Cys Lys Ile Lys Ala Ile Met Ala Leu Val Ala Ala Ile Leu Leu
115 120 125
Leu Val Ile Ile Ile Leu Ile Val Met Lys Tyr Arg Thr
130 135 140
<210> 258
<211> 307
<212> PRT
<213> 人类
<400> 258
Met Ala Thr Arg Arg Leu Thr Asp Ala Phe Leu Leu Leu Arg Asn Asn
1 5 10 15
Ser Ile Gln Asn Arg Gln Leu Leu Ala Glu Gln Glu Leu Asp Glu Leu
20 25 30
Ala Asp Asp Arg Met Ala Leu Val Ser Gly Ile Ser Leu Asp Pro Glu
35 40 45
Ala Ala Ile Gly Val Thr Lys Arg Pro Pro Pro Lys Trp Val Asp Gly
50 55 60
Val Asp Glu Ile Gln Tyr Asp Val Gly Arg Ile Lys Gln Lys Met Lys
65 70 75 80
Glu Leu Ala Ser Leu His Asp Lys His Leu Asn Arg Pro Thr Leu Asp
85 90 95
Asp Ser Ser Glu Glu Glu His Ala Ile Glu Ile Thr Thr Gln Glu Ile
100 105 110
Thr Gln Leu Phe His Arg Cys Gln Arg Ala Val Gln Pro Cys Arg Ala
115 120 125
Gly Lys Gly Pro Ala Pro Ser Arg Arg Gly Gly Cys Leu Gly Thr Trp
130 135 140
Cys Leu Val Ala Gln Ala Leu Gln Glu Leu Ser Thr Ser Phe Arg His
145 150 155 160
Ala Gln Ser Gly Tyr Leu Lys Arg Met Lys Asn Arg Glu Glu Arg Ser
165 170 175
Gln His Phe Phe Asp Thr Ser Val Pro Leu Met Asp Asp Gly Asp Asp
180 185 190
Asn Thr Leu Tyr His Arg Gly Phe Thr Glu Asp Gln Leu Val Leu Val
195 200 205
Glu Gln Asn Thr Leu Met Val Glu Glu Arg Glu Arg Glu Ile Arg Gln
210 215 220
Ile Val Gln Ser Ile Ser Asp Leu Asn Glu Ile Phe Arg Asp Leu Gly
225 230 235 240
Ala Met Ile Val Glu Gln Gly Thr Val Leu Asp Arg Ile Asp Tyr Asn
245 250 255
Val Glu Gln Ser Cys Ile Lys Thr Glu Asp Gly Leu Lys Gln Leu His
260 265 270
Lys Ala Glu Gln Tyr Gln Lys Lys Asn Arg Lys Met Leu Val Ile Leu
275 280 285
Ile Leu Phe Val Ile Ile Ile Val Leu Ile Val Val Leu Val Gly Val
290 295 300
Lys Ser Arg
305
<210> 259
<211> 249
<212> PRT
<213> 人类
<400> 259
Met Ser Leu Glu Asp Pro Phe Phe Val Val Arg Gly Glu Val Gln Lys
1 5 10 15
Ala Val Asn Thr Ala Arg Gly Leu Tyr Gln Arg Trp Cys Glu Leu Leu
20 25 30
Gln Glu Ser Ala Ala Val Gly Arg Glu Glu Leu Asp Trp Thr Thr Asn
35 40 45
Glu Leu Arg Asn Gly Leu Arg Ser Ile Glu Trp Asp Leu Glu Asp Leu
50 55 60
Glu Glu Thr Ile Gly Ile Val Glu Ala Asn Pro Gly Lys Phe Lys Leu
65 70 75 80
Pro Ala Gly Asp Leu Gln Glu Arg Lys Val Phe Val Glu Arg Met Arg
85 90 95
Glu Ala Val Gln Glu Met Lys Asp His Met Val Ser Pro Thr Ala Val
100 105 110
Ala Phe Leu Glu Arg Asn Asn Arg Glu Ile Leu Ala Gly Lys Pro Ala
115 120 125
Ala Gln Lys Ser Pro Ser Asp Leu Leu Asp Ala Ser Ala Val Ser Ala
130 135 140
Thr Ser Arg Tyr Ile Glu Glu Gln Gln Ala Thr Gln Gln Leu Ile Met
145 150 155 160
Asp Glu Gln Asp Gln Gln Leu Glu Met Val Ser Gly Ser Ile Gln Val
165 170 175
Leu Lys His Met Ser Gly Arg Val Gly Glu Glu Leu Asp Glu Gln Gly
180 185 190
Ile Met Leu Asp Ala Phe Ala Gln Glu Met Asp His Thr Gln Ser Arg
195 200 205
Met Asp Gly Val Leu Arg Lys Leu Ala Lys Val Ser His Met Thr Ser
210 215 220
Asp Arg Arg Gln Trp Cys Ala Ile Ala Val Leu Val Gly Val Leu Leu
225 230 235 240
Leu Val Leu Ile Leu Leu Phe Ser Leu
245
<210> 260
<211> 297
<212> PRT
<213> 人类
<400> 260
Met Arg Asp Arg Thr His Glu Leu Arg Gln Gly Asp Asp Ser Ser Asp
1 5 10 15
Glu Glu Asp Lys Glu Arg Val Ala Leu Val Val His Pro Gly Thr Ala
20 25 30
Arg Leu Gly Ser Pro Asp Glu Glu Phe Phe His Lys Val Arg Thr Ile
35 40 45
Arg Gln Thr Ile Val Lys Leu Gly Asn Lys Val Gln Glu Leu Glu Lys
50 55 60
Gln Gln Val Thr Ile Leu Ala Thr Pro Leu Pro Glu Glu Ser Met Lys
65 70 75 80
Gln Glu Leu Gln Asn Leu Arg Asp Glu Ile Lys Gln Leu Gly Arg Glu
85 90 95
Ile Arg Leu Gln Leu Lys Ala Ile Glu Pro Gln Lys Glu Glu Ala Asp
100 105 110
Glu Asn Tyr Asn Ser Val Asn Thr Arg Met Arg Lys Thr Gln His Gly
115 120 125
Val Leu Ser Gln Gln Phe Val Glu Leu Ile Asn Lys Cys Asn Ser Met
130 135 140
Gln Ser Glu Tyr Arg Glu Lys Asn Val Glu Arg Ile Arg Arg Gln Leu
145 150 155 160
Lys Ile Thr Asn Ala Gly Met Val Ser Asp Glu Glu Leu Glu Gln Met
165 170 175
Leu Asp Ser Gly Gln Ser Glu Val Phe Val Ser Asn Ile Leu Lys Asp
180 185 190
Thr Gln Val Thr Arg Gln Ala Leu Asn Glu Ile Ser Ala Arg His Ser
195 200 205
Glu Ile Gln Gln Leu Glu Arg Ser Ile Arg Glu Leu His Asp Ile Phe
210 215 220
Thr Phe Leu Ala Thr Glu Val Glu Met Gln Gly Glu Met Ile Asn Arg
225 230 235 240
Ile Glu Lys Asn Ile Leu Ser Ser Ala Asp Tyr Val Glu Arg Gly Gln
245 250 255
Glu His Val Lys Thr Ala Leu Glu Asn Gln Lys Lys Ala Arg Lys Lys
260 265 270
Lys Val Leu Ile Ala Ile Cys Val Ser Ile Thr Val Val Leu Leu Ala
275 280 285
Val Ile Ile Gly Val Thr Val Val Gly
290 295
<210> 261
<211> 212
<212> PRT
<213> 人类
<400> 261
Met Asp Pro Leu Phe Gln Gln Thr His Lys Gln Val His Glu Ile Gln
1 5 10 15
Ser Cys Met Gly Arg Leu Glu Thr Ala Asp Lys Gln Ser Val His Ile
20 25 30
Val Glu Asn Glu Ile Gln Ala Ser Ile Asp Gln Ile Phe Ser Arg Leu
35 40 45
Glu Arg Leu Glu Ile Leu Ser Ser Lys Glu Pro Pro Asn Lys Arg Gln
50 55 60
Asn Ala Arg Leu Arg Val Asp Gln Leu Lys Tyr Asp Val Gln His Leu
65 70 75 80
Gln Thr Ala Leu Arg Asn Phe Gln His Arg Arg His Ala Arg Glu Gln
85 90 95
Gln Glu Arg Gln Arg Glu Glu Leu Leu Cys Arg Thr Phe Thr Thr Asn
100 105 110
Gly Ser Asp Thr Thr Ile Pro Met Asp Glu Ser Leu Gln Phe Asn Ser
115 120 125
Ser Leu Gln Lys Val His Asn Gly Met Asp Asp Leu Ile Leu Asp Gly
130 135 140
His Asn Ile Leu Asp Gly Leu Arg Thr Gln Arg Leu Thr Leu Lys Gly
145 150 155 160
Thr Gln Lys Lys Ile Pro Asp Ile Ala Asn Met Leu Gly Leu Ser Asn
165 170 175
Thr Val Met Arg Leu Ile Glu Lys Arg Ala Phe Gln Asp Lys Tyr Phe
180 185 190
Met Ile Gly Gly Met Leu Leu Thr Cys Val Val Met Phe Leu Val Val
195 200 205
Gln Tyr Leu Thr
210
<210> 262
<211> 289
<212> PRT
<213> 人类
<400> 262
Met Lys Asp Arg Leu Glu Gln Leu Lys Ala Lys Gln Leu Thr Gln Asp
1 5 10 15
Asp Asp Thr Asp Ala Val Glu Ile Ala Ile Asp Asn Thr Ala Phe Met
20 25 30
Asp Glu Phe Phe Ser Glu Ile Glu Glu Thr Arg Leu Asn Ile Asp Lys
35 40 45
Ile Ser Glu His Val Glu Glu Ala Lys Lys Leu Tyr Ser Ile Ile Leu
50 55 60
Ser Ala Pro Ile Pro Glu Pro Lys Thr Lys Asp Asp Leu Glu Gln Leu
65 70 75 80
Thr Thr Glu Ile Lys Lys Arg Ala Asn Asn Val Arg Asn Lys Leu Lys
85 90 95
Ser Met Glu Lys His Ile Glu Glu Asp Glu Val Arg Ser Ser Ala Asp
100 105 110
Leu Arg Ile Arg Lys Ser Gln His Ser Val Leu Ser Arg Lys Phe Val
115 120 125
Glu Val Met Thr Lys Tyr Asn Glu Ala Gln Val Asp Phe Arg Glu Arg
130 135 140
Ser Lys Gly Arg Ile Gln Arg His Val Glu Ile Thr Gly Lys Lys Thr
145 150 155 160
Thr Asp Glu Glu Leu Glu Glu Met Leu Glu Ser Gly Asn Pro Ala Ile
165 170 175
Phe Thr Ser Gly Ile Ile Asp Ser Gln Ile Ser Lys Gln Ala Leu Ser
180 185 190
Glu Ile Glu Gly Arg His Lys Asp Ile Val Arg Leu Glu Ser Ser Ile
195 200 205
Lys Glu Leu His Asp Met Phe Met Asp Ile Ala Met Leu Val Glu Asn
210 215 220
Gln Gly Glu Met Leu Asp Asn Ile Glu Leu Asn Val Met His Thr Val
225 230 235 240
Asp His Val Glu Lys Ala Arg Asp Glu Ser Lys Lys Ala Val Lys Tyr
245 250 255
Gln Ser Gln Ala Arg Lys Lys Leu Ile Ile Ile Ile Val Leu Val Val
260 265 270
Val Leu Leu Gly Ile Leu Ala Leu Ile Ile Gly Leu Ser Val Gly Leu
275 280 285
Asn
<210> 263
<211> 297
<212> PRT
<213> 人类
<400> 263
Met Arg Asp Arg Thr His Glu Leu Arg Gln Gly Asp Asp Ser Ser Asp
1 5 10 15
Glu Glu Asp Lys Glu Arg Val Ala Leu Val Val His Pro Gly Thr Ala
20 25 30
Arg Leu Gly Ser Pro Asp Glu Glu Phe Phe His Lys Val Arg Thr Ile
35 40 45
Arg Gln Thr Ile Val Lys Leu Gly Asn Lys Val Gln Glu Leu Glu Lys
50 55 60
Gln Gln Val Thr Ile Leu Ala Thr Pro Leu Pro Glu Glu Ser Met Lys
65 70 75 80
Gln Glu Leu Gln Asn Leu Arg Asp Glu Ile Lys Gln Leu Gly Arg Glu
85 90 95
Ile Arg Leu Gln Leu Lys Ala Ile Glu Pro Gln Lys Glu Glu Ala Asp
100 105 110
Glu Asn Tyr Asn Ser Val Asn Thr Arg Met Arg Lys Thr Gln His Gly
115 120 125
Val Leu Ser Gln Gln Phe Val Glu Leu Ile Asn Lys Cys Asn Ser Met
130 135 140
Gln Ser Glu Tyr Arg Glu Lys Asn Val Glu Arg Ile Arg Arg Gln Leu
145 150 155 160
Lys Ile Thr Asn Ala Gly Met Val Ser Asp Glu Glu Leu Asp Gln Met
165 170 175
Leu Asp Ser Gly Gln Ser Glu Val Phe Val Ser Asn Ile Leu Lys Asp
180 185 190
Thr Gln Val Thr Arg Gln Ala Leu Asn Glu Ile Ser Ala Arg His Ser
195 200 205
Glu Ile Gln Gln Leu Glu Arg Ser Ile Arg Glu Leu His Asp Ile Phe
210 215 220
Thr Phe Leu Ala Thr Glu Val Glu Met Gln Gly Glu Met Ile Asn Arg
225 230 235 240
Ile Glu Lys Asn Ile Leu Ser Ser Ala Asp Tyr Val Glu Arg Gly Gln
245 250 255
Glu His Val Lys Thr Ala Leu Glu Asn Gln Lys Lys Val Arg Lys Lys
260 265 270
Lys Val Leu Ile Ala Ile Cys Val Ser Ile Thr Val Val Leu Leu Ala
275 280 285
Val Ile Ile Gly Val Thr Val Val Gly
290 295

Claims (5)

1.一种筛选能与SIP30相互作用的物质的方法，包括以下步骤：
a)提供一种由选自从序列SEQ ID Bl到序列SEQ ID B130的任一序列组成的多肽；和
b)检测所述物质与所述SIP30相互作用的能力。
2.如权利要求1的方法，其中检测所述物质与所述SIP30相互作用的能力的步骤还进一步包括测定所述物质与所述蛋白相互作用的亲和力。
3.如权利要求1的方法，其中检测所述物质与SIP30分子相互作用的能力的步骤还进一步包括测定所述物质激活SIP30的能力。
4.一种筛选具有SIP30结合能力的物质的方法，包括如下步骤：
a)在细胞中表达由选自从序列SEQ ID Al到序列SEQ ID A130的任一序列组成的核酸序列编码的重组SIP30多肽；
b)使所述物质与所述重组SIP30多肽接触；和
c)检测所述物质与所述重组SIP30多肽相互作用的能力。
5.一种筛选方法，包括：
a)提供一种含有SIP30蛋白的样品；
b)向所述样品中加入SIP30蛋白；向所述样品中的至少第一部分中加入待测化合物；和
c)将来自所述样品的至少第一部分的至少一个参数和来自所述样品的至少第二部分的至少一个参数进行比较，其中所述的样品的至少第二部分不包括待测化合物。
CN201710216385.9A 2009-09-02 2010-09-02 治疗神经病理性疼痛的组合物及方法 Pending CN107121554A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23906509P 2009-09-02 2009-09-02
US61/239,065 2009-09-02
CN201080049104.1A CN102666877B (zh) 2009-09-02 2010-09-02 治疗神经病理性疼痛的组合物及方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201080049104.1A Division CN102666877B (zh) 2009-09-02 2010-09-02 治疗神经病理性疼痛的组合物及方法

Publications (1)

Publication Number Publication Date
CN107121554A true CN107121554A (zh) 2017-09-01

Family

ID=43649962

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201080049104.1A Expired - Fee Related CN102666877B (zh) 2009-09-02 2010-09-02 治疗神经病理性疼痛的组合物及方法
CN201710216385.9A Pending CN107121554A (zh) 2009-09-02 2010-09-02 治疗神经病理性疼痛的组合物及方法
CN201710216359.6A Pending CN107090027A (zh) 2009-09-02 2010-09-02 治疗神经病理性疼痛的组合物及方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201080049104.1A Expired - Fee Related CN102666877B (zh) 2009-09-02 2010-09-02 治疗神经病理性疼痛的组合物及方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201710216359.6A Pending CN107090027A (zh) 2009-09-02 2010-09-02 治疗神经病理性疼痛的组合物及方法

Country Status (6)

Country Link
US (1) US9068984B2 (zh)
EP (1) EP2473635A4 (zh)
CN (3) CN102666877B (zh)
CA (1) CA2772931A1 (zh)
IL (1) IL218448A0 (zh)
WO (1) WO2011028890A2 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110499369A (zh) * 2018-05-17 2019-11-26 华中农业大学 用于选择母鸡储精能力的snp分子标记及其应用
CN114920806A (zh) * 2022-06-07 2022-08-19 中南大学 多肽及其抗体、以及检测它们的试剂在制备鼻咽癌诊断、预后或治疗制剂中的应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3610019A4 (en) * 2017-04-19 2021-05-12 John Mansell COMPOSITIONS AND METHODS FOR TREATING PAINFUL DISORDERS
CN112175062B (zh) * 2019-07-05 2022-07-15 中国医学科学院基础医学研究所 Sft2b蛋白线性抗原表位以及其在精神分裂症诊断中的用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005014849A2 (en) * 2003-07-03 2005-02-17 Euro-Celtique, S.A. Genes associated with responses to neuropathic pain
WO2007001448A2 (en) * 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2584459A1 (en) * 2004-10-22 2006-04-27 Universite Laval Modulation of neuroglia-derived bdnf in the treatment and prevention of pain

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005014849A2 (en) * 2003-07-03 2005-02-17 Euro-Celtique, S.A. Genes associated with responses to neuropathic pain
WO2007001448A2 (en) * 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GUANGDUN PENG，ET AL.: "SIP30 Is Regulated by ERK in Peripheral Nerve Injury-induced Neuropathic Pain", 《THE JOURNAL OF BIOLOGICAL CHEMISTRY》 *
HO-KI LEE，ET AL.: "Identification of a novel SNAP25 interacting protein (SIP30)", 《JOURNAL OF NEUROCHEMISTRY》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110499369A (zh) * 2018-05-17 2019-11-26 华中农业大学 用于选择母鸡储精能力的snp分子标记及其应用
CN110499369B (zh) * 2018-05-17 2021-03-23 华中农业大学 用于选择母鸡储精能力的snp分子标记及其应用
CN114920806A (zh) * 2022-06-07 2022-08-19 中南大学 多肽及其抗体、以及检测它们的试剂在制备鼻咽癌诊断、预后或治疗制剂中的应用
CN114920806B (zh) * 2022-06-07 2023-09-12 中南大学 多肽及其抗体、以及检测它们的试剂在制备鼻咽癌诊断、预后或治疗制剂中的应用

Also Published As

Publication number Publication date
CN107090027A (zh) 2017-08-25
CA2772931A1 (en) 2011-03-10
WO2011028890A3 (en) 2011-05-05
US9068984B2 (en) 2015-06-30
EP2473635A4 (en) 2013-03-13
WO2011028890A2 (en) 2011-03-10
IL218448A0 (en) 2012-04-30
EP2473635A2 (en) 2012-07-11
CN102666877B (zh) 2018-06-12
CN102666877A (zh) 2012-09-12
US20120245216A1 (en) 2012-09-27

Similar Documents

Publication Publication Date Title
AU2017267184B2 (en) Method for assessing a prognosis and predicting the response of patients with malignant diseases to immunotherapy
KR101234281B1 (ko) 염색체 안정화에 관한 유전자를 표적으로 하는 암세포 특이적 아포토시스 유도제
KR102239125B1 (ko) 인간 이디오타입을 갖는 설치류 항체를 인코딩하는 폴리뉴클레오티드 및 이를 포함하는 동물
AU2016364667A1 (en) Materials and methods for treatment of Alpha-1 antitrypsin deficiency
KR20120082906A (ko) 자가포식현상-향상 유전자 생성물의 조절을 통한 자가포식현상의 조절 방법
WO1995014772A1 (fr) Signature genique
JP2003135075A (ja) 新規な全長ｃＤＮＡ
JP2003088388A (ja) 新規な全長ｃＤＮＡ
KR20220054401A (ko) 감염의 숙주 rna 바이오마커의 신속한 조기-검출 및 인간의 covid-19 코로나바이러스 감염의 조기 식별을 위한 시스템, 방법 및 조성물
KR20220025749A (ko) 대장암의 검출
CN101258250A (zh) 用于乳腺癌的诊断的方法
KR20040065524A (ko) 백혈병을 검사 및 치료하는 방법
KR20220024184A (ko) 대장암의 검출
JP2003304888A (ja) 化合物の毒性予測のための方法
KR101743211B1 (ko) 선천성 기능장애 진단용 조성물 및 이의 용도
AU2016202635B2 (en) Method for assessing embryotoxicity
KR20160059446A (ko) 암 유전체 돌연변이 검출용 유전자 패널
CN107121554A (zh) 治疗神经病理性疼痛的组合物及方法
AU2018210420A1 (en) Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci
KR20190126812A (ko) 질환 진단용 바이오마커
CN100516876C (zh) 用于诊断肾细胞癌(rcc)和其他实体瘤的方法
KR102477906B1 (ko) 유도만능 줄기세포 분화 특이적 lncRNA, 및 이의 용도
JP2002017375A (ja) 全長ｃＤＮＡ合成用プライマー、およびその用途
KR102356537B1 (ko) 선천성 기능장애 진단용 조성물 및 이의 용도
KR101816921B1 (ko) 선천성 기능장애 진단용 조성물 및 이의 용도

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1243164

Country of ref document: HK

WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20170901

WD01 Invention patent application deemed withdrawn after publication
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1243164

Country of ref document: HK