ZA200404633B - Combination of cytochome P450 dependent protease inhibitors. - Google Patents
Combination of cytochome P450 dependent protease inhibitors. Download PDFInfo
- Publication number
- ZA200404633B ZA200404633B ZA200404633A ZA200404633A ZA200404633B ZA 200404633 B ZA200404633 B ZA 200404633B ZA 200404633 A ZA200404633 A ZA 200404633A ZA 200404633 A ZA200404633 A ZA 200404633A ZA 200404633 B ZA200404633 B ZA 200404633B
- Authority
- ZA
- South Africa
- Prior art keywords
- het
- formula
- alkyl
- inhibitor
- cytochrome
- Prior art date
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01204841 | 2001-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200404633B true ZA200404633B (en) | 2005-09-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200404633A ZA200404633B (en) | 2001-12-12 | 2004-06-10 | Combination of cytochome P450 dependent protease inhibitors. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20050119338A1 (de) |
| EP (1) | EP1458447B1 (de) |
| JP (1) | JP2005511723A (de) |
| KR (1) | KR100974921B1 (de) |
| CN (1) | CN100335060C (de) |
| AR (1) | AR037797A1 (de) |
| AT (1) | ATE442189T1 (de) |
| AU (1) | AU2002358713B2 (de) |
| BR (1) | BR0215043A (de) |
| CA (1) | CA2469343C (de) |
| CY (1) | CY1110604T1 (de) |
| DE (1) | DE60233677D1 (de) |
| DK (1) | DK1458447T3 (de) |
| ES (1) | ES2333206T3 (de) |
| HK (1) | HK1070008A1 (de) |
| HR (1) | HRP20040619A2 (de) |
| HU (1) | HUP0402644A3 (de) |
| IL (1) | IL162353A0 (de) |
| MX (1) | MXPA04005755A (de) |
| NO (1) | NO20042666L (de) |
| NZ (1) | NZ533826A (de) |
| PL (1) | PL373072A1 (de) |
| PT (1) | PT1458447E (de) |
| RU (1) | RU2329050C2 (de) |
| SI (1) | SI1458447T1 (de) |
| TW (1) | TWI286476B (de) |
| WO (1) | WO2003049746A2 (de) |
| ZA (1) | ZA200404633B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2537877C (en) * | 2003-09-30 | 2015-03-17 | Tibotec Pharmaceuticals Ltd. | Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof |
| EP1715847A1 (de) * | 2003-12-23 | 2006-11-02 | Tibotec Pharmaceuticals Ltd. | Selbstmikroemulgierende arzneiabgabesysteme eines hiv-protease-hemmers |
| CN1997363B (zh) * | 2004-05-07 | 2012-03-28 | 塞阔伊亚药品公司 | 抗耐药性反转录病毒蛋白酶抑制剂 |
| CN1984654A (zh) * | 2004-07-08 | 2007-06-20 | 泰博特克药品有限公司 | 抗－hiv逆转录酶和蛋白酶抑制剂的组合 |
| MX2007010378A (es) | 2005-02-25 | 2007-09-25 | Tibotec Pharm Ltd | Sintesis del precursor inhibidor de la proteasa. |
| US20070003608A1 (en) * | 2005-04-08 | 2007-01-04 | Almond Merrick R | Compounds, compositions and methods for the treatment of viral infections and other medical disorders |
| AR053845A1 (es) * | 2005-04-15 | 2007-05-23 | Tibotec Pharm Ltd | 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450 |
| TWI385173B (zh) * | 2005-11-28 | 2013-02-11 | Tibotec Pharm Ltd | 作為ｈｉｖ蛋白酶抑制劑之經取代的胺基苯基磺醯胺化合物 |
| AR058238A1 (es) | 2005-11-28 | 2008-01-23 | Tibotec Pharm Ltd | Compuestos y derivados de aminofenilsulfonamida sustituida como inhibidores de proteasa del vih |
| US20070219243A1 (en) * | 2005-12-30 | 2007-09-20 | Kearney Brian P | Method for improving the pharmacokinetics of HIV integrase inhibitors |
| JO2841B1 (en) | 2006-06-23 | 2014-09-15 | تيبوتيك فارماسيوتيكالز ليمتد | 2-(substituted-amino) -benzothiazole sulfonamide as protease inhibitors HIV (HIV) |
| JP2010501583A (ja) | 2006-08-18 | 2010-01-21 | セコイア、ファーマシューティカルズ、インコーポレイテッド | シトクロムｐ４５０を阻害するための組成物および方法 |
| CA2681718A1 (en) * | 2007-03-23 | 2008-10-02 | University Of Massachusetts | Hiv-1 protease inhibitors |
| UA103013C2 (uk) | 2007-12-06 | 2013-09-10 | Тиботек Фармасьютикелз | Амідні сполуки як активатори противірусних препаратів |
| PA8809601A1 (es) * | 2007-12-24 | 2009-07-23 | Cipla Ltd | Combinación anti-retroviral |
| CN101977610B (zh) | 2008-01-25 | 2012-05-16 | 奇默里克斯公司 | 治疗病毒感染的方法 |
| NZ591951A (en) | 2008-10-07 | 2013-02-22 | Janssen R & D Ireland | New amide compounds as boosters of antivirals |
| WO2010132494A1 (en) | 2009-05-11 | 2010-11-18 | Ghosh Arun K | Compounds and methods for treating aids and hiv infections |
| JO3090B1 (ar) * | 2009-12-11 | 2017-03-15 | Janssen Sciences Ireland Uc | 5- امينو-4- هيدروكسي-بنتويل اميدات |
| PT2534150T (pt) | 2010-02-12 | 2017-05-02 | Chimerix Inc | Métodos para tratar uma infecção viral |
| CA2797601A1 (en) | 2010-04-26 | 2011-11-10 | Chimerix, Inc. | Methods of treating retroviral infections and related dosage regimes |
| US8513291B2 (en) * | 2010-06-01 | 2013-08-20 | Angion Biomedica Corp. | Cytochrome P450 inhibitors and uses thereof |
| DK2729130T3 (en) | 2011-07-07 | 2017-12-11 | Janssen Sciences Ireland Uc | Darunavir-COMBINATION FORMULATIONS |
| WO2013004816A1 (en) | 2011-07-07 | 2013-01-10 | Janssen R&D Ireland | Darunavir formulations |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995010281A1 (en) * | 1993-10-13 | 1995-04-20 | Merck & Co., Inc. | Combination therapy for hiv infection |
| US6037157A (en) * | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| ATE320811T1 (de) * | 1996-08-05 | 2006-04-15 | Myriad Genetics Inc | Verwendung von beta-blatt mimetika als protease und kinase hemmer und alshemmer eines transkriptionsfaktors |
| US6180634B1 (en) * | 1997-11-13 | 2001-01-30 | Merck & Co., Inc. | Combination therapy for the treatment of AIDS |
| US6436989B1 (en) * | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| AU4828199A (en) * | 1998-06-23 | 2000-01-10 | Board Of Trustees Of The University Of Illinois, The | Multi-drug resistant retroviral protease inhibitors and associated methods |
| CA2336160C (en) * | 1998-06-23 | 2015-02-17 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Use of compounds for treating hiv |
| MY145265A (en) * | 1998-07-20 | 2012-01-13 | Abbott Lab | Amorphous ritonavir |
| SI1159278T1 (sl) * | 1999-02-12 | 2006-06-30 | Vertex Pharma | Inhibitorji aspartil proteaze |
| TWI260322B (en) * | 1999-02-12 | 2006-08-21 | Vertex Pharma | Inhibitors of aspartyl protease |
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2002
- 2002-12-11 AR ARP020104805A patent/AR037797A1/es unknown
- 2002-12-11 TW TW091135882A patent/TWI286476B/zh not_active IP Right Cessation
- 2002-12-12 IL IL16235302A patent/IL162353A0/xx unknown
- 2002-12-12 RU RU2004121144/15A patent/RU2329050C2/ru not_active IP Right Cessation
- 2002-12-12 US US10/498,024 patent/US20050119338A1/en not_active Abandoned
- 2002-12-12 NZ NZ533826A patent/NZ533826A/en not_active IP Right Cessation
- 2002-12-12 SI SI200230865T patent/SI1458447T1/sl unknown
- 2002-12-12 ES ES02793018T patent/ES2333206T3/es not_active Expired - Lifetime
- 2002-12-12 BR BR0215043-3A patent/BR0215043A/pt not_active Application Discontinuation
- 2002-12-12 CA CA002469343A patent/CA2469343C/en not_active Expired - Fee Related
- 2002-12-12 EP EP02793018A patent/EP1458447B1/de not_active Revoked
- 2002-12-12 CN CNB028249119A patent/CN100335060C/zh not_active Expired - Fee Related
- 2002-12-12 PL PL02373072A patent/PL373072A1/xx not_active IP Right Cessation
- 2002-12-12 DE DE60233677T patent/DE60233677D1/de not_active Expired - Lifetime
- 2002-12-12 WO PCT/EP2002/014277 patent/WO2003049746A2/en active Application Filing
- 2002-12-12 DK DK02793018.9T patent/DK1458447T3/da active
- 2002-12-12 AT AT02793018T patent/ATE442189T1/de not_active IP Right Cessation
- 2002-12-12 AU AU2002358713A patent/AU2002358713B2/en not_active Revoked
- 2002-12-12 JP JP2003550795A patent/JP2005511723A/ja active Pending
- 2002-12-12 KR KR1020047008830A patent/KR100974921B1/ko not_active IP Right Cessation
- 2002-12-12 HU HU0402644A patent/HUP0402644A3/hu unknown
- 2002-12-12 PT PT02793018T patent/PT1458447E/pt unknown
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2004
- 2004-06-10 ZA ZA200404633A patent/ZA200404633B/en unknown
- 2004-06-14 MX MXPA04005755A patent/MXPA04005755A/es active IP Right Grant
- 2004-06-24 NO NO20042666A patent/NO20042666L/no not_active Application Discontinuation
- 2004-07-07 HR HR20040619A patent/HRP20040619A2/hr not_active Application Discontinuation
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2005
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