ZA200404586B - Compounds for the treatment of inflammatory disorders. - Google Patents
Compounds for the treatment of inflammatory disorders. Download PDFInfo
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- ZA200404586B ZA200404586B ZA200404586A ZA200404586A ZA200404586B ZA 200404586 B ZA200404586 B ZA 200404586B ZA 200404586 A ZA200404586 A ZA 200404586A ZA 200404586 A ZA200404586 A ZA 200404586A ZA 200404586 B ZA200404586 B ZA 200404586B
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- 230000008506 pathogenesis Effects 0.000 description 1
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 description 1
- 125000005936 piperidyl group Chemical group 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 108091007196 stromelysin Proteins 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 125000003507 tetrahydrothiofenyl group Chemical group 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 230000008354 tissue degradation Effects 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
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Classifications
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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---|---|---|---|---|
WO2005020977A1 (en) | 2003-08-21 | 2005-03-10 | Wisconsin Alumni Research Foundation | Alpha-ketoglutarate potentiators of insulin secretion |
CN1901971A (zh) * | 2003-12-15 | 2007-01-24 | 日本烟草产业株式会社 | 环丙烷化合物及其药物应用 |
WO2005061448A1 (en) * | 2003-12-24 | 2005-07-07 | Monash University | Compositions and methods for treating vascular conditions |
US8759335B2 (en) * | 2004-01-30 | 2014-06-24 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
US7977322B2 (en) | 2004-08-20 | 2011-07-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
US7676590B2 (en) * | 2004-05-03 | 2010-03-09 | Microsoft Corporation | Background transcoding |
TWI350168B (en) | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
WO2006012227A2 (en) * | 2004-06-24 | 2006-02-02 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
US20060009491A1 (en) * | 2004-06-24 | 2006-01-12 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
CN101044188B (zh) * | 2004-10-29 | 2010-08-04 | 桑多斯股份公司 | 制备格拉太咪尔的方法 |
RU2007126842A (ru) | 2004-12-14 | 2009-01-27 | Санофи-Авентис Дойчланд Гмбх (De) | Применение замещенных производных циклопропановой кислоты для получения лекарственных средств для лечения метаболического синдрома |
US7879997B2 (en) * | 2005-08-12 | 2011-02-01 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
TW200804382A (en) | 2005-12-05 | 2008-01-16 | Incyte Corp | Lactam compounds and methods of using the same |
US7998959B2 (en) | 2006-01-12 | 2011-08-16 | Incyte Corporation | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
EP2018378A2 (en) | 2006-05-17 | 2009-01-28 | Incyte Corporation | Heterocyclic inhibitors of 11-b hydroxyl steroid dehydrogenase type i and methods of using the same |
US8153166B2 (en) * | 2006-06-08 | 2012-04-10 | Chih-Hsiung Lin | Composition for prophylaxis or treatment of urinary system infection and method thereof |
US9108948B2 (en) * | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
CN103382174A (zh) | 2006-06-23 | 2013-11-06 | 雅培制药有限公司 | 作为组胺h3受体调节物的环丙胺衍生物 |
EP2408753A4 (en) * | 2009-03-20 | 2012-11-07 | Univ Brandeis | COMPOUNDS AND METHOD FOR THE TREATMENT OF MICROBIAL STOMACH DARM INFECTIONS IN MAMMALS |
US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
CN102241627B (zh) * | 2010-05-14 | 2014-07-02 | 中国人民解放军总医院 | 脲类化合物及其医药用途 |
WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
EP3485889B1 (en) * | 2011-12-16 | 2023-09-06 | Poseida Therapeutics, Inc. | Trpc4 modulators for use in the treatment or prevention of pain |
EP3074375B1 (en) * | 2013-11-28 | 2018-04-04 | Boehringer Ingelheim International GmbH | New indanyloxyphenylcyclopropanecarboxylic acids |
MX2016014911A (es) | 2014-05-14 | 2017-04-06 | Univ Colorado Regents | Acidos hidroxamicos heterociclicos como inhibidores de proteina desacetilasa e inhibidores dobles de proteina desacetilasa-proteina cinasa, y metodos de uso de los mismos. |
KR20220164216A (ko) * | 2021-06-04 | 2022-12-13 | 에스티팜 주식회사 | 신규한 에르고스텐올 유도체 및 이의 용도 |
Family Cites Families (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3740412A (en) | 1970-04-08 | 1973-06-19 | Synvar Ass | Imidazoline-3-oxide-1-oxyl derivatives |
US3997223A (en) | 1975-04-30 | 1976-12-14 | Dynascan Corporation | Apparatus and method for rejuvenating cathode ray tubes |
US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
US4267333A (en) | 1979-09-26 | 1981-05-12 | Union Carbide Agricultural Products Company, Inc. | Preparation of 2-trifluoromethyl cinchoninic acids |
US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
US4435419A (en) * | 1981-07-01 | 1984-03-06 | American Cyanamid Company | Method of treating depression using azabicyclohexanes |
US4431661A (en) | 1981-08-20 | 1984-02-14 | American Cyanamid Company | 5-Aryl-3-azabicyclo[3.2.0]heptan-6-one acetals, and analgesic use therefor |
AU534404B2 (en) * | 1981-09-01 | 1984-01-26 | American Cyanamid Company | Cyclopropane derivatives |
US4490055A (en) | 1982-06-30 | 1984-12-25 | International Business Machines Corporation | Automatically adjustable delay function for timed typamatic |
US4544665A (en) | 1983-11-21 | 1985-10-01 | American Cyanamid Company | 1-Aryl-3-azabicyclo[3.2.0]heptanes |
GB2200628A (en) * | 1987-02-06 | 1988-08-10 | Shell Int Research | Diphenyl ether herbicides |
US5089633A (en) | 1987-04-28 | 1992-02-18 | Georgia Tech Research Corporation | Substituted isocoumarins |
GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
JPH032797A (ja) | 1989-05-30 | 1991-01-09 | Meidensha Corp | 音声合成装置の抑揚制御方式 |
US5120752A (en) | 1989-12-28 | 1992-06-09 | Abbott Laboratories | Cyclopropyl derivative lipoxygenase inhibitors |
US5037853A (en) | 1989-12-28 | 1991-08-06 | Abbott Laboratories | Cyclopropyl derivative lipoxygenase inhibitors |
US5114953A (en) | 1990-11-21 | 1992-05-19 | University Of Florida | Treatment for tissue ulceration |
GB9102635D0 (en) | 1991-02-07 | 1991-03-27 | British Bio Technology | Compounds |
US5256657A (en) | 1991-08-19 | 1993-10-26 | Sterling Winthrop, Inc. | Succinamide derivative matrix-metalloprotease inhibitors |
WO1993007111A1 (en) | 1991-10-02 | 1993-04-15 | Smithkline Beecham Corporation | Cyclopentane and cyclopentene derivatives with antiallergic antiinflammatory and tumor necrosis factor inhibiting activity |
JPH05262698A (ja) * | 1992-03-24 | 1993-10-12 | Dainippon Ink & Chem Inc | 光学活性トリフルオロメチルシクロプロパン誘導体、その合成中間体、それを含む液晶組成物及び液晶表示素子 |
EP0634998B1 (en) | 1992-04-07 | 1997-03-19 | British Biotech Pharmaceuticals Limited | Hydroxamic acid based collagenase and cytokine inhibitors |
US5674901A (en) | 1995-06-01 | 1997-10-07 | Wisconsin Alumni Research Foundation | Methods of treating animals to maintain or increase CD-4 and CD-8 cell populations |
US5318964A (en) | 1992-06-11 | 1994-06-07 | Hoffmann-La Roche Inc. | Hydroxamic derivatives and pharmaceutical compositions |
EP0648225A1 (en) | 1992-06-25 | 1995-04-19 | Chiron Corporation | Compositions for the inhibition of protein hormone formation and uses thereof |
GB9215665D0 (en) | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
GB9223904D0 (en) | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
US5646167A (en) | 1993-01-06 | 1997-07-08 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamix acids |
US5552419A (en) | 1993-01-06 | 1996-09-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
US5506242A (en) | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
CN1105799A (zh) | 1993-03-18 | 1995-07-26 | 大制药株式会社 | 作为基质金属蛋白酶抑制剂的喹诺酮衍生物 |
GB9307956D0 (en) | 1993-04-17 | 1993-06-02 | Walls Alan J | Hydroxamic acid derivatives |
JPH072797A (ja) | 1993-04-19 | 1995-01-06 | Sankyo Co Ltd | コラゲナーゼ阻害剤 |
GB9311282D0 (en) | 1993-06-01 | 1993-07-21 | Rhone Poulenc Rorer Ltd | New compositions of matter |
US5594106A (en) | 1993-08-23 | 1997-01-14 | Immunex Corporation | Inhibitors of TNF-α secretion |
EP0715619A4 (en) | 1993-08-23 | 1997-03-19 | Immunex Corp | INHIBITORS OF TNF-ALPHA SECRETION |
GB9320660D0 (en) | 1993-10-07 | 1993-11-24 | British Bio Technology | Inhibition of cytokine production |
US5514716A (en) | 1994-02-25 | 1996-05-07 | Sterling Winthrop, Inc. | Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof |
GB9501737D0 (en) | 1994-04-25 | 1995-03-22 | Hoffmann La Roche | Hydroxamic acid derivatives |
US5817822A (en) | 1994-06-24 | 1998-10-06 | Novartis Corporation | Certain alpha-azacycloalkyl substituted arylsulfonamido acetohydroxamic acids |
JP2902318B2 (ja) | 1994-12-28 | 1999-06-07 | 呉羽化学工業株式会社 | エスクレチン誘導体、その製造方法及びマトリックスメタロプロテアーゼ阻害剤 |
US5703092A (en) | 1995-04-18 | 1997-12-30 | The Dupont Merck Pharmaceutical Company | Hydroxamic acid compounds as metalloprotease and TNF inhibitors |
US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
GB9514867D0 (en) | 1995-07-20 | 1995-09-20 | British Biotech Pharm | Metalloproteinase inhibitors |
KR980009238A (ko) | 1995-07-28 | 1998-04-30 | 우에노 도시오 | 설포닐아미노산 유도체 |
US5665777A (en) | 1995-11-14 | 1997-09-09 | Abbott Laboratories | Biphenyl hydroxamate inhibitors of matrix metalloproteinases |
PL326714A1 (en) | 1995-11-14 | 1998-10-26 | Du Pont Merck Pharma | Novel macrocyclic compounds as inhibitors of metaloproteinases |
TR199800990T2 (xx) | 1995-12-08 | 1998-07-21 | Agouron Pharmaceuticals, Inc. | Metaloproteinaz inhibit�rleri, bunlar� i�eren farmas�tik bile�imler, bunlar�n farmas�tik kullan�mlar� ve bunlar�n �retiminde kullan�labilecek y�ntemler ve ara �r�nler. |
US5753653A (en) | 1995-12-08 | 1998-05-19 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
TW453995B (en) | 1995-12-15 | 2001-09-11 | Novartis Ag | Certain alpha-substituted arylsulfonamido acetohydroxamic acids |
PT780386E (pt) | 1995-12-20 | 2003-02-28 | Hoffmann La Roche | Inibidores de metaloprotease de matriz |
PT871439E (pt) | 1996-01-02 | 2004-08-31 | Aventis Pharma Inc | Compostos do acido hidroxamico substituidos (arilo heteroarilo arilmetilo ou heteroarilmetilo) |
JPH09202774A (ja) * | 1996-01-25 | 1997-08-05 | Green Cross Corp:The | 2−アリールキノリン類およびその製造方法 |
TW448172B (en) | 1996-03-08 | 2001-08-01 | Pharmacia & Upjohn Co Llc | Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation |
IT1283637B1 (it) | 1996-05-14 | 1998-04-23 | Italfarmaco Spa | Composti ad attivita' antinfiammatoria ed immunosoppressiva |
US5853977A (en) | 1996-07-12 | 1998-12-29 | Schering Corporation | Mammalian TNF-α convertases |
EP0818442A3 (en) | 1996-07-12 | 1998-12-30 | Pfizer Inc. | Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor |
JP3539736B2 (ja) | 1996-08-28 | 2004-07-07 | ザ プロクター アンド ギャンブル カンパニー | 基質メタロプロテアーゼインヒビターとしてのホスフィン酸アミド |
US5962481A (en) | 1996-10-16 | 1999-10-05 | American Cyanamid Company | Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors |
US6548524B2 (en) | 1996-10-16 | 2003-04-15 | American Cyanamid Company | Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors |
US5977408A (en) | 1996-10-16 | 1999-11-02 | American Cyanamid Company | Preparation and use of β-sulfonamido hydroxamic acids as matrix metalloproteinase and TACE inhibitors |
JPH10130217A (ja) | 1996-11-01 | 1998-05-19 | Kotobuki Seiyaku Kk | カルボン酸及びその誘導体及びその製造法並びにこれを含有する医薬組成物 |
US5837696A (en) | 1997-01-15 | 1998-11-17 | The Research Foundation Of State University Of New York | Method of inhibiting cancer growth |
JPH10204054A (ja) | 1997-01-21 | 1998-08-04 | Ono Pharmaceut Co Ltd | フェニルスルホンアミド誘導体 |
JPH10204059A (ja) | 1997-01-22 | 1998-08-04 | Ono Pharmaceut Co Ltd | フェニルスルホンアミド誘導体 |
US6197791B1 (en) | 1997-02-27 | 2001-03-06 | American Cyanamid Company | N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
US6172057B1 (en) | 1997-02-27 | 2001-01-09 | American Cyanamid Company | N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
WO1998040088A1 (en) | 1997-03-11 | 1998-09-17 | Les Laboratoires Aeterna Inc. | Compositions for treating tumors containing shark cartilage extracts and anti-neoplastic agents |
US5985900A (en) | 1997-04-01 | 1999-11-16 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
DE59802394D1 (de) | 1997-05-09 | 2002-01-24 | Hoechst Ag | Substituierte Diaminocarbonsäuren |
DE19719621A1 (de) | 1997-05-09 | 1998-11-12 | Hoechst Ag | Sulfonylaminocarbonsäuren |
US5804581A (en) | 1997-05-15 | 1998-09-08 | Bayer Corporation | Inhibition of matrix metalloproteases by substituted phenalkyl compounds |
EP0887077A1 (de) | 1997-06-27 | 1998-12-30 | Roche Diagnostics GmbH | Verwendung von Azulenderivaten als Metalloproteaseinhibitoren |
ES2176913T3 (es) | 1997-08-08 | 2002-12-01 | Pfizer Prod Inc | Derivados de acidos arilsulfonilaminohidroxamicos. |
ZA988967B (en) | 1997-10-03 | 2000-04-03 | Du Pont Pharm Co | Lactam metalloprotease inhibitors. |
EP1029851B1 (en) * | 1997-10-14 | 2005-04-20 | Mitsubishi Pharma Corporation | Piperazine compounds and medicinal use thereof |
CA2310593C (en) | 1997-11-13 | 2007-05-08 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
FR2771095B1 (fr) | 1997-11-14 | 1999-12-17 | Adir | Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
EP0922702A1 (de) | 1997-12-13 | 1999-06-16 | Roche Diagnostics GmbH | Neue Azulenderivate und diese enthaltende Arzneimittel |
US6071903A (en) | 1998-01-27 | 2000-06-06 | American Cyanamid Company | 2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepine-3-hydroxyamic acids |
GB9801690D0 (en) | 1998-01-27 | 1998-03-25 | Pfizer Ltd | Therapeutic agents |
ATE266634T1 (de) * | 1998-04-10 | 2004-05-15 | Pfizer Prod Inc | Cyclobutyl-aryloxysulfonylamin- hydroxamsäurederivate |
FR2780402B1 (fr) | 1998-06-30 | 2001-04-27 | Adir | Nouveaux composes acides carboxyliques et hydroxamiques inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
DE19831980A1 (de) | 1998-07-16 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Sulfonylaminophosphin- und phosphonsäurederivate |
EP1004578B1 (en) | 1998-11-05 | 2004-02-25 | Pfizer Products Inc. | 5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives |
US6372747B1 (en) | 1998-12-18 | 2002-04-16 | Schering Corporation | Farnesyl protein transferase inhibitors |
FR2788525B1 (fr) | 1999-01-19 | 2002-11-29 | Commissariat Energie Atomique | Pseudo-peptides phosphiniques, utilisables comme inhibiteurs des metalloproteases a zinc matricielles |
US6294539B1 (en) | 1999-01-19 | 2001-09-25 | Advanced Syntech, Llc | Heterocyclic hydroxamic acid derivatives as MMP inhibitors |
US6225311B1 (en) | 1999-01-27 | 2001-05-01 | American Cyanamid Company | Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors |
US6313123B1 (en) | 1999-01-27 | 2001-11-06 | American Cyanamid Company | Acetylenic sulfonamide thiol tace inhibitors |
US6326516B1 (en) | 1999-01-27 | 2001-12-04 | American Cyanamid Company | Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors |
US6277885B1 (en) | 1999-01-27 | 2001-08-21 | American Cyanamid Company | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors |
US6200996B1 (en) | 1999-01-27 | 2001-03-13 | American Cyanamid Company | Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors |
US6177077B1 (en) | 1999-02-24 | 2001-01-23 | Edward L. Tobinick | TNT inhibitors for the treatment of neurological disorders |
ES2200783T3 (es) | 1999-03-31 | 2004-03-16 | Pfizer Products Inc. | Acidos dioxociclopentil hidroxamicos. |
EP1165500A1 (en) * | 1999-04-02 | 2002-01-02 | Du Pont Pharmaceuticals Company | Amide derivatives as inhibitors of matrix metalloproteinases,tnf-alpha,and aggrecanase |
EP1081137A1 (en) | 1999-08-12 | 2001-03-07 | Pfizer Products Inc. | Selective inhibitors of aggrecanase in osteoarthritis treatment |
-
2002
- 2002-12-13 PE PE2002001221A patent/PE20030701A1/es not_active Application Discontinuation
- 2002-12-18 TW TW091136497A patent/TW200306809A/zh unknown
- 2002-12-19 US US10/323,511 patent/US6838466B2/en not_active Expired - Fee Related
- 2002-12-19 AU AU2002357885A patent/AU2002357885A1/en not_active Abandoned
- 2002-12-19 CA CA002470620A patent/CA2470620A1/en not_active Abandoned
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- 2002-12-19 CN CNA028281705A patent/CN1620424A/zh active Pending
- 2002-12-19 HU HU0500016A patent/HUP0500016A2/hu unknown
- 2002-12-19 JP JP2003554632A patent/JP4439265B2/ja not_active Expired - Fee Related
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CN1620424A (zh) | 2005-05-25 |
WO2003053915A3 (en) | 2003-09-18 |
KR20040068599A (ko) | 2004-07-31 |
AU2002357885A1 (en) | 2003-07-09 |
MXPA04006031A (es) | 2004-09-27 |
US20040102418A1 (en) | 2004-05-27 |
US20040038941A1 (en) | 2004-02-26 |
EP1458676A2 (en) | 2004-09-22 |
JP2005513125A (ja) | 2005-05-12 |
US20060063843A1 (en) | 2006-03-23 |
US7034057B2 (en) | 2006-04-25 |
JP4439265B2 (ja) | 2010-03-24 |
HUP0500016A2 (hu) | 2005-04-28 |
WO2003053915A2 (en) | 2003-07-03 |
AR037929A1 (es) | 2004-12-22 |
CA2470620A1 (en) | 2003-07-03 |
TW200306809A (en) | 2003-12-01 |
US6838466B2 (en) | 2005-01-04 |
JP2010006817A (ja) | 2010-01-14 |
PE20030701A1 (es) | 2003-08-21 |
IL162485A0 (en) | 2005-11-20 |
US7598242B2 (en) | 2009-10-06 |
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