ZA200403602B - Oligopeptides and compositions containing them as cathepsin S inhibitors. - Google Patents
Oligopeptides and compositions containing them as cathepsin S inhibitors.Info
- Publication number
- ZA200403602B ZA200403602B ZA200403602A ZA200403602A ZA200403602B ZA 200403602 B ZA200403602 B ZA 200403602B ZA 200403602 A ZA200403602 A ZA 200403602A ZA 200403602 A ZA200403602 A ZA 200403602A ZA 200403602 B ZA200403602 B ZA 200403602B
- Authority
- ZA
- South Africa
- Prior art keywords
- cathepsin
- oligopeptides
- inhibitors
- compositions containing
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33260501P | 2001-11-14 | 2001-11-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200403602B true ZA200403602B (en) | 2005-08-31 |
Family
ID=23298977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200403602A ZA200403602B (en) | 2001-11-14 | 2004-05-11 | Oligopeptides and compositions containing them as cathepsin S inhibitors. |
Country Status (21)
Country | Link |
---|---|
US (3) | US6977256B2 (zh) |
EP (1) | EP1446392A1 (zh) |
JP (1) | JP2005514353A (zh) |
KR (1) | KR20050044497A (zh) |
CN (1) | CN1324018C (zh) |
BR (1) | BR0214104A (zh) |
CA (1) | CA2467391A1 (zh) |
CO (1) | CO5640128A2 (zh) |
HK (1) | HK1073840A1 (zh) |
HR (1) | HRP20040426A2 (zh) |
HU (1) | HUP0401906A3 (zh) |
IL (1) | IL161950A0 (zh) |
MA (1) | MA27140A1 (zh) |
MX (1) | MXPA04004450A (zh) |
NO (1) | NO20041909L (zh) |
NZ (1) | NZ532167A (zh) |
PL (1) | PL372105A1 (zh) |
RU (1) | RU2004117877A (zh) |
WO (1) | WO2003042197A1 (zh) |
YU (1) | YU34604A (zh) |
ZA (1) | ZA200403602B (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005504078A (ja) * | 2001-09-14 | 2005-02-10 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | カテプシン阻害剤としての新規化合物および組成物 |
EP1446392A1 (en) * | 2001-11-14 | 2004-08-18 | Aventis Pharmaceuticals, Inc. | Oligopeptides and compositions containing them as cathepsin s inhibitors |
US7091360B2 (en) * | 2002-04-16 | 2006-08-15 | Aventis Pharma S.A. | Process for preparing heteroaryl and unsaturated heterocycloalkylmagnesium reagents and uses thereof |
KR20080103117A (ko) | 2002-09-24 | 2008-11-26 | 노파르티스 아게 | 탈수초성 장애의 치료에 있어서의 스핑고신-1-포스페이트 수용체 아고니스트 |
JP5587790B2 (ja) | 2008-01-09 | 2014-09-10 | アミュラ セラピューティクス リミティド | 化合物 |
CN104800196A (zh) | 2008-06-20 | 2015-07-29 | 诺华股份有限公司 | 用于治疗多发性硬化的儿科组合物 |
US8895497B2 (en) * | 2009-12-04 | 2014-11-25 | Dcb-Usa, Llc | Cathepsin S inhibitors |
Family Cites Families (70)
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US5874424A (en) | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
DE3606480A1 (de) | 1986-02-28 | 1987-09-03 | Behringwerke Ag | Oligopeptidylnitrilderivate, diese enthaltende mittel, verfahren zu ihrer herstellung und ihre verwendung |
US5055451A (en) | 1986-12-22 | 1991-10-08 | Syntex Inc. | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors |
GB8809316D0 (en) | 1987-05-11 | 1988-05-25 | Ici America Inc | Heterocyclic ketones |
JPS63303868A (ja) | 1987-06-03 | 1988-12-12 | Oki Electric Ind Co Ltd | 誘電体セラミックスの製造方法 |
DE3827415A1 (de) | 1988-08-12 | 1990-02-15 | Behringwerke Ag | Peptidderivate, verfahren zu ihrer herstellung und ihre verwendung |
EP0376012A3 (en) | 1988-12-27 | 1992-05-06 | American Cyanamid Company | Renin inhibitors |
EP0419683A4 (en) | 1989-04-13 | 1992-03-11 | Japan Tobacco Inc. | New amino acid derivatives having prolylendopeptidase inhibitor activity |
CA2084204A1 (en) | 1990-06-07 | 1991-12-08 | Akihiro Okubo | Arylalkanoylamine derivative and drug containing the same |
JPH06192199A (ja) | 1992-12-25 | 1994-07-12 | Mitsubishi Kasei Corp | ケトン誘導体 |
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CN1174504A (zh) | 1993-11-09 | 1998-02-25 | 麦克公司 | 促进生长激素释放的哌啶、吡咯烷和六氢-1h-吖庚因 |
IL111785A0 (en) | 1993-12-03 | 1995-01-24 | Ferring Bv | Dp-iv inhibitors and pharmaceutical compositions containing them |
US5714484A (en) | 1993-12-08 | 1998-02-03 | Prototek, Inc. | α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors |
US5486623A (en) | 1993-12-08 | 1996-01-23 | Prototek, Inc. | Cysteine protease inhibitors containing heterocyclic leaving groups |
JPH07228529A (ja) | 1994-02-17 | 1995-08-29 | Zeria Pharmaceut Co Ltd | コリンエステラーゼ賦活剤 |
WO1995024382A1 (en) | 1994-03-10 | 1995-09-14 | G.D. Searle & Co. | L-n6-(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors |
US5847135A (en) | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
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EP1155011A1 (en) | 1999-02-20 | 2001-11-21 | AstraZeneca AB | Di- and tripeptide nitrile derivatives as inhibitors of cathepsin l and cathepsin s |
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GB9925264D0 (en) | 1999-10-26 | 1999-12-29 | Zeneca Ltd | Chemical compounds |
HU227039B1 (en) | 2000-01-25 | 2010-05-28 | Egis Gyogyszergyar Nyilvanosan | New process for the production of quetiapine and intermediates therefor |
GB0003111D0 (en) | 2000-02-10 | 2000-03-29 | Novartis Ag | Organic compounds |
CA2435117A1 (en) | 2001-01-17 | 2002-07-25 | Amura Therapeutics Limited | Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases |
US7425562B2 (en) | 2001-01-17 | 2008-09-16 | Amura Therapeutics Ltd. | Inhibitors of cruzipain and other cysteine proteases |
US7132449B2 (en) | 2001-01-17 | 2006-11-07 | Amura Therapeutics Limited | Inhibitors of cruzipain and other cysteine proteases |
US20040204368A1 (en) | 2001-05-31 | 2004-10-14 | Kazuyuki Ohmoto | Oxadiazole derivative compounds and drugs containing these compounds as the active ingredient |
EP1397340A2 (en) * | 2001-06-01 | 2004-03-17 | Axys Pharmaceuticals, Inc. | Chemical compounds and pharmaceutical compositions as cathepsin s inhibitors |
US6982263B2 (en) | 2001-06-08 | 2006-01-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nitriles useful as reversible inhibitors of cysteine proteases |
JP2005504078A (ja) * | 2001-09-14 | 2005-02-10 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | カテプシン阻害剤としての新規化合物および組成物 |
EP1446392A1 (en) * | 2001-11-14 | 2004-08-18 | Aventis Pharmaceuticals, Inc. | Oligopeptides and compositions containing them as cathepsin s inhibitors |
-
2002
- 2002-11-14 EP EP02792253A patent/EP1446392A1/en not_active Withdrawn
- 2002-11-14 IL IL16195002A patent/IL161950A0/xx unknown
- 2002-11-14 KR KR1020047007466A patent/KR20050044497A/ko not_active Application Discontinuation
- 2002-11-14 MX MXPA04004450A patent/MXPA04004450A/es not_active Application Discontinuation
- 2002-11-14 WO PCT/US2002/036396 patent/WO2003042197A1/en active Application Filing
- 2002-11-14 JP JP2003544033A patent/JP2005514353A/ja active Pending
- 2002-11-14 NZ NZ532167A patent/NZ532167A/en unknown
- 2002-11-14 RU RU2004117877/04A patent/RU2004117877A/ru not_active Application Discontinuation
- 2002-11-14 US US10/294,526 patent/US6977256B2/en not_active Expired - Fee Related
- 2002-11-14 HU HU0401906A patent/HUP0401906A3/hu unknown
- 2002-11-14 CN CNB028226879A patent/CN1324018C/zh not_active Expired - Fee Related
- 2002-11-14 PL PL02372105A patent/PL372105A1/xx not_active Application Discontinuation
- 2002-11-14 BR BR0214104-3A patent/BR0214104A/pt not_active IP Right Cessation
- 2002-11-14 CA CA002467391A patent/CA2467391A1/en not_active Abandoned
- 2002-11-14 YU YU34604A patent/YU34604A/sh unknown
-
2004
- 2004-04-06 MA MA27611A patent/MA27140A1/fr unknown
- 2004-05-10 NO NO20041909A patent/NO20041909L/no not_active Application Discontinuation
- 2004-05-11 ZA ZA200403602A patent/ZA200403602B/xx unknown
- 2004-05-12 CO CO04043885A patent/CO5640128A2/es unknown
- 2004-05-13 HR HR20040426A patent/HRP20040426A2/hr not_active Application Discontinuation
-
2005
- 2005-06-24 US US11/166,829 patent/US7226921B2/en not_active Expired - Fee Related
- 2005-07-25 HK HK05106311A patent/HK1073840A1/xx not_active IP Right Cessation
-
2007
- 2007-04-26 US US11/740,414 patent/US20070203138A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MXPA04004450A (es) | 2004-08-11 |
NZ532167A (en) | 2006-11-30 |
HK1073840A1 (en) | 2005-10-21 |
CN1585757A (zh) | 2005-02-23 |
CO5640128A2 (es) | 2006-05-31 |
HUP0401906A2 (hu) | 2004-12-28 |
US6977256B2 (en) | 2005-12-20 |
WO2003042197A1 (en) | 2003-05-22 |
US20030199506A1 (en) | 2003-10-23 |
RU2004117877A (ru) | 2006-01-10 |
HRP20040426A2 (en) | 2004-10-31 |
YU34604A (sh) | 2006-08-17 |
PL372105A1 (en) | 2005-07-11 |
EP1446392A1 (en) | 2004-08-18 |
US20050267044A1 (en) | 2005-12-01 |
CN1324018C (zh) | 2007-07-04 |
US7226921B2 (en) | 2007-06-05 |
JP2005514353A (ja) | 2005-05-19 |
NO20041909L (no) | 2004-05-10 |
IL161950A0 (en) | 2005-11-20 |
MA27140A1 (fr) | 2005-01-03 |
US20070203138A1 (en) | 2007-08-30 |
KR20050044497A (ko) | 2005-05-12 |
BR0214104A (pt) | 2004-09-28 |
HUP0401906A3 (en) | 2008-07-28 |
CA2467391A1 (en) | 2003-05-22 |
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