ZA200403063B - 1,8-naphthyridine derivatives as antidiabetics. - Google Patents
1,8-naphthyridine derivatives as antidiabetics. Download PDFInfo
- Publication number
- ZA200403063B ZA200403063B ZA200403063A ZA200403063A ZA200403063B ZA 200403063 B ZA200403063 B ZA 200403063B ZA 200403063 A ZA200403063 A ZA 200403063A ZA 200403063 A ZA200403063 A ZA 200403063A ZA 200403063 B ZA200403063 B ZA 200403063B
- Authority
- ZA
- South Africa
- Prior art keywords
- carbon atoms
- heterocycloalkyl
- heteroatoms selected
- substituted
- heterocycloalkenyl
- Prior art date
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- 150000005058 1,8-naphthyridines Chemical class 0.000 title description 3
- 230000003178 anti-diabetic effect Effects 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 claims description 1585
- 125000005842 heteroatom Chemical group 0.000 claims description 499
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 452
- 229910052717 sulfur Inorganic materials 0.000 claims description 433
- 229910052757 nitrogen Inorganic materials 0.000 claims description 355
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims description 272
- 125000000217 alkyl group Chemical group 0.000 claims description 159
- 229910052760 oxygen Inorganic materials 0.000 claims description 159
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 143
- 125000001188 haloalkyl group Chemical group 0.000 claims description 129
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 128
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 108
- 125000003342 alkenyl group Chemical group 0.000 claims description 97
- 125000000304 alkynyl group Chemical group 0.000 claims description 96
- 229910052739 hydrogen Inorganic materials 0.000 claims description 93
- 239000001257 hydrogen Substances 0.000 claims description 93
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 93
- 150000001875 compounds Chemical class 0.000 claims description 82
- 125000001072 heteroaryl group Chemical group 0.000 claims description 55
- 125000003545 alkoxy group Chemical group 0.000 claims description 53
- 125000003118 aryl group Chemical group 0.000 claims description 46
- 125000000000 cycloalkoxy group Chemical group 0.000 claims description 46
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 41
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 40
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| EP1467730A4 (en) * | 2002-01-22 | 2010-03-10 | Univ California | Non-steroid ligands for the glucocorticoid receptor, compositions and uses thereof |
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| DE602004024814D1 (de) * | 2003-11-04 | 2010-02-04 | Merck & Co Inc | Substituierte naphthyridinonderivate |
| EP1734963A4 (en) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER |
| BRPI0514381A (pt) * | 2004-07-30 | 2008-06-10 | Palumed Sa | compostos hìbridos de aminoquinolina-antibiótico, composições farmacêuticas, método de preparação e uso destes |
| FR2874922A1 (fr) * | 2004-07-30 | 2006-03-10 | Palumed Sa | Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| US7645885B2 (en) * | 2005-08-26 | 2010-01-12 | The Regents Of The University Of California | Non-steroidal antiandrogens |
| AU2006304787A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| EP2068872A1 (en) | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| WO2008074068A1 (en) * | 2006-12-20 | 2008-06-26 | Prana Biotechnology Limited | Substituted quinoline derivatives as antiamyloidogeneic agents |
| US8063066B2 (en) * | 2007-03-19 | 2011-11-22 | Takeda Pharmaceutical Company Limited | MAPK/ERK kinase inhibitors |
| US10017827B2 (en) | 2007-04-04 | 2018-07-10 | Nidera S.A. | Herbicide-resistant sunflower plants with multiple herbicide resistant alleles of AHASL1 and methods of use |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| CA2741125A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
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| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| SI2448938T1 (sl) | 2009-06-29 | 2014-08-29 | Incyte Corporation Experimental Station | Pirimidinoni kot zaviralci pi3k |
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| US9193721B2 (en) | 2010-04-14 | 2015-11-24 | Incyte Holdings Corporation | Fused derivatives as PI3Kδ inhibitors |
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| ES2764848T3 (es) | 2010-12-20 | 2020-06-04 | Incyte Holdings Corp | N-(1-(fenilo sustituido)etilo)-9H-purina-6-aminas como inhibidores de PI3K |
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| US9108984B2 (en) | 2011-03-14 | 2015-08-18 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors |
| WO2012135009A1 (en) | 2011-03-25 | 2012-10-04 | Incyte Corporation | Pyrimidine-4,6-diamine derivatives as pi3k inhibitors |
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