IL160708A0 - 1, 6-naphthyridine derivatives as antidiabetics - Google Patents
1, 6-naphthyridine derivatives as antidiabeticsInfo
- Publication number
- IL160708A0 IL160708A0 IL16070802A IL16070802A IL160708A0 IL 160708 A0 IL160708 A0 IL 160708A0 IL 16070802 A IL16070802 A IL 16070802A IL 16070802 A IL16070802 A IL 16070802A IL 160708 A0 IL160708 A0 IL 160708A0
- Authority
- IL
- Israel
- Prior art keywords
- antidiabetics
- naphthyridine derivatives
- naphthyridine
- derivatives
- Prior art date
Links
- VSOSXKMEQPYESP-UHFFFAOYSA-N 1,6-naphthyridine Chemical class C1=CN=CC2=CC=CN=C21 VSOSXKMEQPYESP-UHFFFAOYSA-N 0.000 title 1
- 230000003178 anti-diabetic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32451101P | 2001-09-26 | 2001-09-26 | |
| PCT/US2002/030376 WO2003027113A1 (en) | 2001-09-26 | 2002-09-23 | 1,6-naphthyridine derivatives as antidiabetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL160708A0 true IL160708A0 (en) | 2004-08-31 |
Family
ID=23263913
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16070802A IL160708A0 (en) | 2001-09-26 | 2002-09-23 | 1, 6-naphthyridine derivatives as antidiabetics |
| IL16070702A IL160707A0 (en) | 2001-09-26 | 2002-09-23 | 1, 8-naphthyridine derivatives as antidiabetics |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16070702A IL160707A0 (en) | 2001-09-26 | 2002-09-23 | 1, 8-naphthyridine derivatives as antidiabetics |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US6677352B1 (pl) |
| EP (2) | EP1432711A1 (pl) |
| JP (2) | JP2005504807A (pl) |
| KR (2) | KR20040041178A (pl) |
| CN (2) | CN1578780A (pl) |
| AR (2) | AR037503A1 (pl) |
| BR (2) | BR0212829A (pl) |
| CA (2) | CA2461132A1 (pl) |
| CO (2) | CO5560611A2 (pl) |
| EC (2) | ECSP045084A (pl) |
| GT (2) | GT200200191A (pl) |
| HN (1) | HN2002000275A (pl) |
| HR (2) | HRP20040309A2 (pl) |
| HU (2) | HUP0402310A2 (pl) |
| IL (2) | IL160708A0 (pl) |
| MA (2) | MA26344A1 (pl) |
| MX (2) | MXPA04002136A (pl) |
| NO (2) | NO20041567L (pl) |
| PE (2) | PE20030549A1 (pl) |
| PL (2) | PL369567A1 (pl) |
| RU (2) | RU2004112771A (pl) |
| UY (2) | UY27457A1 (pl) |
| WO (2) | WO2003027112A1 (pl) |
| ZA (2) | ZA200403064B (pl) |
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|---|---|---|---|---|
| HUP0402310A2 (hu) * | 2001-09-26 | 2005-02-28 | Bayer Pharmaceuticals Corporation | 1,6-Naftiridin-származékok mint antidiabetikumok és ezeket tartalmazó gyógyszerkészítmények |
| JP4745609B2 (ja) * | 2002-01-22 | 2011-08-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | グルココルチコイドレセプターのための非ステロイド性リガンド、その組成物および使用 |
| WO2005018567A2 (en) * | 2003-08-22 | 2005-03-03 | Bayer Pharmaceuticals Corporation | Compounds and compositions for the treatment of diabetes and diabetes-related disorders |
| WO2005047285A1 (en) * | 2003-11-04 | 2005-05-26 | Merck & Co., Inc. | Substituted naphthyridinone derivatives |
| WO2005097127A2 (en) | 2004-04-02 | 2005-10-20 | Merck & Co., Inc. | Method of treating men with metabolic and anthropometric disorders |
| FR2874922A1 (fr) * | 2004-07-30 | 2006-03-10 | Palumed Sa | Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien |
| CA2572442A1 (fr) * | 2004-07-30 | 2006-03-09 | Palumed S.A. | Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien |
| US7645885B2 (en) * | 2005-08-26 | 2010-01-12 | The Regents Of The University Of California | Non-steroidal antiandrogens |
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| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| WO2008074068A1 (en) * | 2006-12-20 | 2008-06-26 | Prana Biotechnology Limited | Substituted quinoline derivatives as antiamyloidogeneic agents |
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| US10017827B2 (en) | 2007-04-04 | 2018-07-10 | Nidera S.A. | Herbicide-resistant sunflower plants with multiple herbicide resistant alleles of AHASL1 and methods of use |
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| EA201690035A1 (ru) | 2011-02-25 | 2016-05-31 | Мерк Шарп Энд Домэ Корп. | Новые циклические производные азабензимидазола, используемые в качестве антидиабетических агентов |
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| DE4303657A1 (de) | 1993-02-09 | 1994-08-11 | Bayer Ag | Neue Chinolon- und Naphthyridoncarbonsäurederivate |
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| JP3242792B2 (ja) | 1994-08-05 | 2001-12-25 | 日本臓器製薬株式会社 | ナフチリジニウム誘導体 |
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| US6331555B1 (en) | 1995-06-01 | 2001-12-18 | University Of California | Treatment of platelet derived growth factor related disorders such as cancers |
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| JP4323574B2 (ja) | 1995-12-13 | 2009-09-02 | 大日本住友製薬株式会社 | 抗腫瘍剤 |
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| US5994367A (en) | 1997-03-07 | 1999-11-30 | The University Of North Carolina At Chapel Hill | Method for treating tumors using 2-aryl-naphthyridin-4-ones |
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| KR100286874B1 (ko) | 1998-03-04 | 2001-04-16 | 성재갑 | 보호된 4-아미노메틸-피롤리딘-3-온의 제조방법 |
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| AU4694999A (en) * | 1998-08-06 | 2000-02-28 | Warner-Lambert Company | Use of thiazolidinedione derivatives for the treatment or prevention of cataracts |
| US6423721B1 (en) | 1998-09-10 | 2002-07-23 | Schering Corporation | Methods and compositions for treating sinusitis, otitis media and other related disorders using antihistamines |
| JP4681734B2 (ja) | 1998-09-18 | 2011-05-11 | 千寿製薬株式会社 | ピリドンカルボン酸の可溶化方法、その可溶化剤、ピリドンカルボン酸含有水溶液剤およびその製造方法 |
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| HUP0402310A2 (hu) * | 2001-09-26 | 2005-02-28 | Bayer Pharmaceuticals Corporation | 1,6-Naftiridin-származékok mint antidiabetikumok és ezeket tartalmazó gyógyszerkészítmények |
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2002
- 2002-09-23 HU HU0402310A patent/HUP0402310A2/hu unknown
- 2002-09-23 US US10/253,215 patent/US6677352B1/en not_active Expired - Fee Related
- 2002-09-23 WO PCT/US2002/030176 patent/WO2003027112A1/en active Application Filing
- 2002-09-23 CA CA002461132A patent/CA2461132A1/en not_active Abandoned
- 2002-09-23 PL PL02369567A patent/PL369567A1/pl unknown
- 2002-09-23 CN CNA028230191A patent/CN1578780A/zh active Pending
- 2002-09-23 MX MXPA04002136A patent/MXPA04002136A/es not_active Application Discontinuation
- 2002-09-23 CA CA002463039A patent/CA2463039A1/en not_active Abandoned
- 2002-09-23 HU HU0401889A patent/HUP0401889A2/hu unknown
- 2002-09-23 BR BR0212829-2A patent/BR0212829A/pt not_active Application Discontinuation
- 2002-09-23 RU RU2004112771/04A patent/RU2004112771A/ru not_active Application Discontinuation
- 2002-09-23 WO PCT/US2002/030376 patent/WO2003027113A1/en active Application Filing
- 2002-09-23 KR KR10-2004-7004339A patent/KR20040041178A/ko not_active Application Discontinuation
- 2002-09-23 PL PL02369531A patent/PL369531A1/pl unknown
- 2002-09-23 JP JP2003530700A patent/JP2005504807A/ja not_active Withdrawn
- 2002-09-23 JP JP2003530701A patent/JP2005504808A/ja not_active Withdrawn
- 2002-09-23 US US10/253,104 patent/US6900205B2/en not_active Expired - Lifetime
- 2002-09-23 RU RU2004112787/04A patent/RU2004112787A/ru not_active Application Discontinuation
- 2002-09-23 KR KR10-2004-7004338A patent/KR20040041177A/ko not_active Application Discontinuation
- 2002-09-23 EP EP02799627A patent/EP1432711A1/en not_active Withdrawn
- 2002-09-23 CN CNA028230213A patent/CN1578781A/zh active Pending
- 2002-09-23 IL IL16070802A patent/IL160708A0/xx unknown
- 2002-09-23 IL IL16070702A patent/IL160707A0/xx unknown
- 2002-09-23 BR BR0212864-0A patent/BR0212864A/pt not_active Application Discontinuation
- 2002-09-23 MX MXPA04002035A patent/MXPA04002035A/es unknown
- 2002-09-23 EP EP02799608A patent/EP1432710A1/en not_active Withdrawn
- 2002-09-25 PE PE2002000943A patent/PE20030549A1/es not_active Application Discontinuation
- 2002-09-25 PE PE2002000944A patent/PE20030601A1/es not_active Application Discontinuation
- 2002-09-25 AR ARP020103609A patent/AR037503A1/es unknown
- 2002-09-25 AR ARP020103610A patent/AR037504A1/es unknown
- 2002-09-26 GT GT200200191A patent/GT200200191A/es unknown
- 2002-09-26 UY UY27457A patent/UY27457A1/es not_active Application Discontinuation
- 2002-09-26 UY UY27456A patent/UY27456A1/es not_active Application Discontinuation
- 2002-09-26 GT GT200200194A patent/GT200200194A/es unknown
- 2002-09-26 HN HN2002000275A patent/HN2002000275A/es unknown
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2003
- 2003-10-10 US US10/684,299 patent/US6964971B2/en not_active Expired - Fee Related
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2004
- 2004-03-24 CO CO04027786A patent/CO5560611A2/es not_active Application Discontinuation
- 2004-03-24 CO CO04027787A patent/CO5560542A2/es unknown
- 2004-03-31 HR HR20040309A patent/HRP20040309A2/hr not_active Application Discontinuation
- 2004-04-02 HR HR20040317A patent/HRP20040317A2/xx not_active Application Discontinuation
- 2004-04-16 NO NO20041567A patent/NO20041567L/no unknown
- 2004-04-16 NO NO20041560A patent/NO20041560L/no unknown
- 2004-04-22 ZA ZA2004/03064A patent/ZA200403064B/en unknown
- 2004-04-22 ZA ZA200403063A patent/ZA200403063B/en unknown
- 2004-04-23 MA MA27652A patent/MA26344A1/fr unknown
- 2004-04-23 MA MA27654A patent/MA27079A1/fr unknown
- 2004-04-23 EC EC2004005084A patent/ECSP045084A/es unknown
- 2004-04-23 EC EC2004005081A patent/ECSP045081A/es unknown
- 2004-04-28 US US10/834,357 patent/US7109196B2/en not_active Expired - Fee Related
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2006
- 2006-04-21 US US11/409,536 patent/US20060189609A1/en not_active Abandoned
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